inositol-1-4-5-trisphosphate and Medulloblastoma

inositol-1-4-5-trisphosphate has been researched along with Medulloblastoma* in 1 studies

Other Studies

1 other study(ies) available for inositol-1-4-5-trisphosphate and Medulloblastoma

ArticleYear
Extracellular acidification elicits spatially and temporally distinct Ca2+ signals.
    Current biology : CB, 2008, May-20, Volume: 18, Issue:10

    Extracellular acidification accompanies neoplastic transformation of tissues and increases with tumor aggressiveness [1, 2]. The intracellular signaling cascade triggered by this process remains poorly understood and may be linked to recently discovered proton-activated G protein-coupled receptors such as OGR1 and G2A [3, 4]. Here, we report that OGR1 and G2A are expressed in human medulloblastoma tissue and its corresponding neuronal cell line. We show that extracellular acidification activates phospholipase C, IP(3) formation, and subsequent Ca2+ release from thapsigargin-sensitive stores in neurons. The number of responsive cells and the amount of Ca2+ released from stores correlated positively with the extent of extracellular acidification. Ca2+ release recruited the MEK/ERK pathway, providing a mechanistic explanation for how acidification stimulates cell growth. In addition, acidification activated Ca2+-permeable ion channels through a mechanism dependent on phospholipase C but independent of store depletion or a cytoplasmic Ca2+ rise. Hence, extracellular acidification, to levels seen in tumor tissue, activates temporally and spatially distinct pathways that elevate Ca2+ and may be directly relevant for tumor cell biology.

    Topics: Calcium Signaling; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Cerebellar Neoplasms; Extracellular Fluid; Humans; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Medulloblastoma; Receptors, G-Protein-Coupled; Type C Phospholipases

2008