inositol-1-4-5-trisphosphate and Coronavirus-Infections

Estrogen hormone acts as a potential key player in providing immunity against certain viral infection. It is found to be associated in providing immunity against acute lungs inflammation and influenza virus by modulating cytokines storm and mediating adaptive immune alterations respectively. Women are less affected by SARS-CoV-2 infection because of the possible influence of estrogen hormone as compared to men. We hypothesized that SARS-CoV-2 causes stress in endoplasmic reticulum (ER) which in turn aggravates the infection, estrogen hormone might play key role in decreasing ER stress by activating estrogen mediated signaling pathways, results in unfolded protein response (UPR). Estrogen governs degradation of phosphotidylinositol 4,5-bisphosphate (PIP

Topics: Adult; Betacoronavirus; Coronavirus Infections; COVID-19; Datasets as Topic; Diglycerides; Disease Resistance; Endoplasmic Reticulum Stress; Estrogens; Female; Humans; Inositol 1,4,5-Trisphosphate; Male; Middle Aged; Models, Biological; Pakistan; Pandemics; Phosphatidylinositol 4,5-Diphosphate; Pneumonia, Viral; SARS-CoV-2; Sex Characteristics; Sex Distribution; Signal Transduction; Type C Phospholipases; Unfolded Protein Response; Viral Proteins