Compounds > inositol-1-4-5-trisphosphate

inositol-1-4-5-trisphosphate and Coronary-Vasospasm

inositol-1-4-5-trisphosphate has been researched along with Coronary-Vasospasm* in 1 studies

Other Studies

1 other study(ies) available for inositol-1-4-5-trisphosphate and Coronary-Vasospasm

Article	Year
[Cellular mechanisms of hypoxic coronary spasm]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1988, Volume: 74, Issue:2 Transient hypoxic contraction (THC) of vascular smooth muscle (VSM) of isolated human, canine and porcine coronary artery rings was preserved in Ca2+--free solution and abolished with procaine. The data obtained suggest that the THC of the coronary VSM is mediated via a Ca2+ release from sarcoplasmic reticulum under the effect of inositol-1,4, 5-triphosphate and may be triggered by action of endogenous noradrenaline on alpha 1-adrenoceptors. The mechanism of beta-adrenergic relaxation was not actualized in the hypoxia because of uncoupling of the beta-adrenoceptors from adenylate cyclase. Topics: Animals; Calcium; Coronary Vasospasm; Coronary Vessels; Dogs; Humans; Hypoxia; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Sarcoplasmic Reticulum; Swine	1988

Article

Year

[Cellular mechanisms of hypoxic coronary spasm].

Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1988, Volume: 74, Issue:2

Transient hypoxic contraction (THC) of vascular smooth muscle (VSM) of isolated human, canine and porcine coronary artery rings was preserved in Ca2+--free solution and abolished with procaine. The data obtained suggest that the THC of the coronary VSM is mediated via a Ca2+ release from sarcoplasmic reticulum under the effect of inositol-1,4, 5-triphosphate and may be triggered by action of endogenous noradrenaline on alpha 1-adrenoceptors. The mechanism of beta-adrenergic relaxation was not actualized in the hypoxia because of uncoupling of the beta-adrenoceptors from adenylate cyclase.

Topics: Animals; Calcium; Coronary Vasospasm; Coronary Vessels; Dogs; Humans; Hypoxia; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Sarcoplasmic Reticulum; Swine

1988