inositol-1-4-5-trisphosphate and Chromosome-Deletion

Expression of inositol 1,4,5-trisphosphate (InsP3) receptor subtypes was determined in mouse brain using oligonucleotide-specific in situ hybridization. All subtypes, except one that deletes 120 bp from the full-length InsP3 receptor cDNA, were expressed in cerebellar Purkinje cells. In hippocampus, various subtypes showed distinct expression patterns. These results suggest that regionally selective expression of InsP3 receptor subtypes may result in the generation of functionally distinct channels.

Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Cerebellum; Chromosome Deletion; Gene Expression; Hippocampus; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Inbred ICR; Molecular Sequence Data; Nucleic Acid Hybridization; Oligonucleotide Probes; Pyramidal Tracts; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; RNA Probes; RNA Splicing; RNA, Messenger; Transcription, Genetic