inosinic-acid has been researched along with Muscular-Dystrophies* in 3 studies
3 other study(ies) available for inosinic-acid and Muscular-Dystrophies
| Article | Year |
|---|---|
[Destruction of muscle tissue and purine compound metabolism in hereditary muscular dystrophy].
The distribution of purine compounds in the skeletal muscles of the anterior and posterior limbs of 129/Re mice with hereditary muscular dystrophy (HMD) was investigated in a comparative study. The results revealed unidirectional metabolic disorders in both groups of muscles which was manifested in a quantitative redistribution of phosphorus-containing purine components and a decrease in the pool of adenylates in muscle tissue. Elevated concentrations of purine metabolites (inosine, hypoxanthine, xanthine, and uric acid) indicated an augmented metabolism of purines in this abnormality. Impairment of metabolic transformations of purines in the muscle tissue in HMD may be one of the factors responsible for the development of the pathological process in the muscle in the given disease. Topics: Adenine Nucleotides; Animals; Hypoxanthine; Hypoxanthines; Inosine; Inosine Monophosphate; Mice; Muscles; Muscular Dystrophies; Purines; Uric Acid; Xanthine; Xanthines | 1986 |
Isotachophoretic analysis of some compounds involved in energy metabolism in normal and pathological human muscle extracts.
Topics: Adenine Nucleotides; Energy Metabolism; Humans; Inosine Monophosphate; Muscles; Muscular Dystrophies; NAD; Phosphocreatine; Reference Values | 1984 |
The purine nucleotide profile in mouse, chicken and human dystrophic muscle: an abnormal ratio of inosine plus adenine nucleotides to guanine nucleotides.
1. AMP, ADP, ATP, IMP, GDP, GTP and adenylosuccinate have been measured by high pressure liquid chromatography in three types of animal muscular dystrophy and in a human patient with Duchenne muscular dystrophy. 2. Abnormalities in nucleotide content varied from one dystrophy to another. 3. In each case, however, the ratio [total adenine nucleotide + IMP]/[total guanine nucleotides] was lower in dystrophic muscle, even when severely exercised or ischaemic muscles were used. 4. The practical advantages of this assay for diagnosis of muscular dystrophy are discussed. Topics: Adenine Nucleotides; Adenosine Monophosphate; Animals; Chickens; Child, Preschool; Guanine Nucleotides; Humans; Inosine Monophosphate; Male; Mice; Mice, Inbred C57BL; Muscles; Muscular Dystrophies; Muscular Dystrophy, Animal; Purine Nucleotides | 1982 |