inosinic-acid and Brain-Ischemia
inosinic-acid has been researched along with Brain-Ischemia* in 1 studies
Other Studies
1 other study(ies) available for inosinic-acid and Brain-Ischemia
Article | Year |
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Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions.
The human phosphomannomutases PMM1 and PMM2 catalyze the interconversion of hexose 6-phosphates and hexose 1-phosphates. The two isoforms share 66% sequence identity and have kinetic properties similar to those of mutases in vitro but differ in their functional roles in vivo. Though the physiological role of PMM2 is catalysis of the mutase reaction that provides the mannose 1-phosphate (Man-1-P) essential for protein glycosylation, PMM1 is thought to provide a phosphohydrolase activity in the presence of inosine monophosphate (IMP), converting glucose 1,6-bisphosphate (Glu-1,6-P Topics: Amino Acid Sequence; Binding Sites; Brain Ischemia; Crystallography, X-Ray; Glycolysis; Humans; Inosine Monophosphate; Models, Molecular; Phosphotransferases (Phosphomutases); Protein Binding; Protein Conformation; Sequence Alignment; Substrate Specificity | 2018 |