inosinic-acid and Biliary-Tract-Diseases

inosinic-acid has been researched along with Biliary-Tract-Diseases* in 1 studies

Other Studies

1 other study(ies) available for inosinic-acid and Biliary-Tract-Diseases

Article	Year
Activation energy of serum 5'-nucleotidase as a marker for enzyme heterogeneity. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1994, Volume: 32, Issue:12 Using adenosine 5'-monophosphate (Arkesteijn; J. Clin. Chem. Clin. Biochem. 14 (1976) 155) and inosine 5'-monophosphate (Bertrand & Buret; Clin. Chim. Acta 119 (1982) 275) as substrates for the determination of serum 5'-nucleotidase, linear Arrhenius plots were obtained between 25 degrees C and 37 degrees C. With the latter method, in patients with hepatobiliary disease, activation energy is higher than in healthy subjects (67.8 +/- 0.8 kJ.mol-1 vs. 59.2 +/- 1.6 kJ.mol-1, p < 0.001). Neuraminidase treatment resulted in a significant reduction in the activation energy of serum 5'-nucleotidase from patients (63.6 +/- 0.6 kJ.mol-1, p < 0.001). Although the activation energy seen is also influenced by conditions other than sialic acid content, the results obtained are in accordance with the hypothesis that in liver disease serum 5'-nucleotidase becomes more sialylated. Topics: 5'-Nucleotidase; Adenosine Monophosphate; Biliary Tract Diseases; Biomarkers; Enzyme Activation; Humans; Inosine Monophosphate; Kinetics; Liver Diseases; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids; Thermodynamics	1994

Article

Year

Activation energy of serum 5'-nucleotidase as a marker for enzyme heterogeneity.

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1994, Volume: 32, Issue:12

Using adenosine 5'-monophosphate (Arkesteijn; J. Clin. Chem. Clin. Biochem. 14 (1976) 155) and inosine 5'-monophosphate (Bertrand & Buret; Clin. Chim. Acta 119 (1982) 275) as substrates for the determination of serum 5'-nucleotidase, linear Arrhenius plots were obtained between 25 degrees C and 37 degrees C. With the latter method, in patients with hepatobiliary disease, activation energy is higher than in healthy subjects (67.8 +/- 0.8 kJ.mol-1 vs. 59.2 +/- 1.6 kJ.mol-1, p < 0.001). Neuraminidase treatment resulted in a significant reduction in the activation energy of serum 5'-nucleotidase from patients (63.6 +/- 0.6 kJ.mol-1, p < 0.001). Although the activation energy seen is also influenced by conditions other than sialic acid content, the results obtained are in accordance with the hypothesis that in liver disease serum 5'-nucleotidase becomes more sialylated.

Topics: 5'-Nucleotidase; Adenosine Monophosphate; Biliary Tract Diseases; Biomarkers; Enzyme Activation; Humans; Inosine Monophosphate; Kinetics; Liver Diseases; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids; Thermodynamics

1994