inosinic-acid and Aneurysm--Ruptured

Bypass with parent artery trapping is an alternative treatment method for ruptured internal carotid artery (ICA) aneurysms when clipping or coiling is contraindicated. However, the efficacy and safety of this strategy during the acute stage of subarachnoid hemorrhage (SAH) is undetermined.. A retrospective review of 955 consecutive patients presenting SAH between 2006 and 2014 identified 17 patients with ruptured ICA aneurysms treated by bypass with parent artery trapping within 72 hours after the bleeding (bypass group). The 26 cases with ruptured posterior communicating artery aneurysms treated with clipping during the same period were defined as a control group (clipping group). Postoperative cerebral blood flow (CBF) was evaluated by single photon emission computed tomography (SPECT). We analyzed the postoperative hemodynamic status, surgical complications, and the clinical outcomes.. Postoperative rebleeding did not occur in any of the cases. CBF in the first postoperative week in the bypass group was lower than that in the clipping group (P = .0165). This CBF decrease improved in the second postoperative week and did not differ from that of the clipping group. The incidence of acute ischemic complications was significantly higher in the bypass group (P = .0284), but the incidence of delayed cerebral ischemia did not differ between the 2 groups. The incidence of favorable outcomes at 6 months was 82.4% in the bypass group and 81% in the clipping group.. Although the transient CBF decrease with acute ischemic complications should be noted, acute bypass with parent artery trapping is safe and effective for unclippable/uncoilable ruptured ICA aneurysms.

Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Revascularization; Cerebrovascular Circulation; Female; Humans; Image Processing, Computer-Assisted; Inosine Monophosphate; Iodine Isotopes; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Statistics, Nonparametric; Tomography Scanners, X-Ray Computed; Tomography, Emission-Computed, Single-Photon