inosine-triphosphate and Purpura--Thrombocytopenic

inosine-triphosphate has been researched along with Purpura--Thrombocytopenic* in 3 studies

Trials

1 trial(s) available for inosine-triphosphate and Purpura--Thrombocytopenic

Article	Year
Dapsone in treatment of chronic idiopathic thrombocytopenic purpura in adults. The Journal of the Association of Physicians of India, 2001, Volume: 49 When a patient is steroid-dependant, a currently available strategy in chronic idiopathic thrombocytopenic purpura (ITP) is to follow a trial and error approach with any of the known drugs which has been found effective in the condition.. To evaluate the response of chronic ITP to dapsone, an inexpensive drug now reported to be effective in the disease.. A controlled trial of abstinence and rechallenge type.. Eight subjects with chronic ITP.. Phase I - Intake of 100 mg of dapsone daily until response (in form of rise of platelet count in blood), Phase II - Above followed by drug abstinence, minimum for four weeks, and then rechallenge with the drug.. Platelet counts during various phases viz during drug intake, withdrawal and rechallenge.. Four (50%) patients responded to treatment. The mean pre-dapsone and post-dapsone platelet counts of blood were 29.6 x 10(9)/l and 142.5 x 10(9)/l respectively during the first phase of trial. The rechallenge was done in five patients following withdrawal of drug and the mean values of platelet count before and after rechallenge were 32.2 x 10(9)/l and 83 x 10(9)/l respectively. There was a remarkable response in two patients; one is now off the drug and the other on a maintenance dose of 50 mg of dapsone daily.. Dapsone caused significant rise of platelet count in some patients of chronic ITP. It can be tried as an alternative to other second-line drugs in chronic ITP. Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dapsone; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Inosine Triphosphate; Male; Purpura, Thrombocytopenic; Treatment Outcome	2001

Article

Year

Dapsone in treatment of chronic idiopathic thrombocytopenic purpura in adults.

The Journal of the Association of Physicians of India, 2001, Volume: 49

When a patient is steroid-dependant, a currently available strategy in chronic idiopathic thrombocytopenic purpura (ITP) is to follow a trial and error approach with any of the known drugs which has been found effective in the condition.. To evaluate the response of chronic ITP to dapsone, an inexpensive drug now reported to be effective in the disease.. A controlled trial of abstinence and rechallenge type.. Eight subjects with chronic ITP.. Phase I - Intake of 100 mg of dapsone daily until response (in form of rise of platelet count in blood), Phase II - Above followed by drug abstinence, minimum for four weeks, and then rechallenge with the drug.. Platelet counts during various phases viz during drug intake, withdrawal and rechallenge.. Four (50%) patients responded to treatment. The mean pre-dapsone and post-dapsone platelet counts of blood were 29.6 x 10(9)/l and 142.5 x 10(9)/l respectively during the first phase of trial. The rechallenge was done in five patients following withdrawal of drug and the mean values of platelet count before and after rechallenge were 32.2 x 10(9)/l and 83 x 10(9)/l respectively. There was a remarkable response in two patients; one is now off the drug and the other on a maintenance dose of 50 mg of dapsone daily.. Dapsone caused significant rise of platelet count in some patients of chronic ITP. It can be tried as an alternative to other second-line drugs in chronic ITP.

Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dapsone; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Inosine Triphosphate; Male; Purpura, Thrombocytopenic; Treatment Outcome

2001

Other Studies

2 other study(ies) available for inosine-triphosphate and Purpura--Thrombocytopenic

Article	Year
Autoimmune thrombocytopenic purpura ("ITP" type) with chronic lymphocytic leukemia. Blood, 1962, Volume: 19 Topics: Humans; Inosine Triphosphate; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Medical Records; Purpura; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	1962
PANELS in therapy. X. Treatment of acute ITP. Blood, 1956, Volume: 11, Issue:4 Topics: Humans; Inosine Triphosphate; Purpura; Purpura, Thrombocytopenic; Thrombocytopenia	1956