inosine-pranobex and Herpes-Labialis

Topics: Amantadine; Animals; Antiviral Agents; Cytarabine; Herpes Labialis; Herpes Simplex; Humans; Idoxuridine; Influenza, Human; Inosine Pranobex; Interferon Inducers; Interferons; Keratitis, Dendritic; Levamisole; Methisazone; Ribavirin; Smallpox; Vidarabine

The objective of the study is to evaluate the efficacy and safety of oral inosine pranobex as compared with acyclovir in the treatment of recurrent herpes labialis (RHL) and recurrent herpes genitalis (RHG). A multicenter double-blind, double-dummy, randomized, controlled, parallel group trial was conducted in 144 patients with RHL and 144 RHG. Patients were assigned to treatment in one of two groups: (i) inosine pranobex group (active inosine pranobex, 1 g four times daily, and acyclovir placebo); or (ii) acyclovir group (active acyclovir, 200 mg five times daily, and inosine pranobex placebo). The total symptom score (TSS) of patients with RHL did not differ in the inosine pranobex and acyclovir group on the 3rd or 7th day of treatment. There was also no difference in the efficacy rates between the two groups. No difference of TSS was observed between patients with RHG taking inosine pranobex and acyclovir on days 3 or 5 of the treatment, respectively. The short-term clinical recurrence rate of RHG at 3-month follow-up was much lower in the inosine pranobex group than acyclovir group. The incidence of hyperuricemia was higher in the inosine pranobex group than acyclovir group. In conclusion, inosine pranobex was as effective as acyclovir in treating RHL and RHG with significantly greater reduction of the short-term recurrence rate of herpes genitalis at 3-month follow up. Long-term recurrence rates at 6 months or longer remain to be determined. Hyperuricemia should be monitored during the treatment.

Topics: Acyclovir; Adult; Antiviral Agents; China; Double-Blind Method; Female; Herpes Genitalis; Herpes Labialis; Humans; Inosine Pranobex; Male; Middle Aged; Recurrence

Topics: Clinical Trials as Topic; Double-Blind Method; Female; Herpes Genitalis; Herpes Labialis; Herpes Simplex; Humans; Inosine; Inosine Pranobex; Male; Recurrence

Topics: Female; Herpes Genitalis; Herpes Labialis; Humans; Inosine; Inosine Pranobex; Male

The reason for giving substances with immunostimulatory properties is to restore or normalize immune functions. Since various human pathogenic viruses can induce immunodepression, the administration of immunostimulants offers a possibility for therapeutic intervention in the immune system. This could be demonstrated. Various virus infections can effectively be influenced by the synthetic immunostimulating agent Inosine Pranobex.

Topics: Antibody Formation; Encephalitis; Female; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Humans; Immunity, Cellular; Immunologic Deficiency Syndromes; Inosine; Inosine Pranobex; Male; Subacute Sclerosing Panencephalitis; Virus Diseases

Topics: Herpes Labialis; Herpesviridae Infections; Humans; Immunity, Cellular; Inosine; Inosine Pranobex; Lymphocytes; Lymphotoxin-alpha; Phytohemagglutinins