inosine-pranobex and Encephalitis

Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Chickenpox; Child; Encephalitis; Enterovirus Infections; Female; Herpesviridae Infections; Humans; Hypnotics and Sedatives; Influenza, Human; Inosine Pranobex; Male; Measles; Mumps; Rubella; Virus Diseases

Topics: Amantadine; Antiviral Agents; Ascorbic Acid; Dosage Forms; Drug Evaluation; Encephalitis; Hepatitis; Herpes Simplex; Herpes Zoster; Humans; Idoxuridine; Influenza, Human; Inosine Pranobex; Interferons; Levamisole; Rimantadine; Subacute Sclerosing Panencephalitis; Trifluridine; Virus Diseases

Topics: Child, Preschool; Electroencephalography; Encephalitis; Humans; Inosine Pranobex; Male; Measles; Measles virus

The reason for giving substances with immunostimulatory properties is to restore or normalize immune functions. Since various human pathogenic viruses can induce immunodepression, the administration of immunostimulants offers a possibility for therapeutic intervention in the immune system. This could be demonstrated. Various virus infections can effectively be influenced by the synthetic immunostimulating agent Inosine Pranobex.

Topics: Antibody Formation; Encephalitis; Female; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Humans; Immunity, Cellular; Immunologic Deficiency Syndromes; Inosine; Inosine Pranobex; Male; Subacute Sclerosing Panencephalitis; Virus Diseases

Motor lesions following herpes zoster are quite common. Hemiparesis, paraparesis, pareses of the facial and other cranial nerves as well as segmental pareses can be observed. We report on a patient suffering from zoster ophthalmicus complicated by paresis of the third cranial nerve. As a cause, a partial brain stem-encephalitis was diagnosed. The patient recovered after antiviral treatment (Aciclovir, Inosiplex).

Topics: Acyclovir; Brain Stem; Encephalitis; Herpes Zoster Ophthalmicus; Humans; Inosine Pranobex; Male; Middle Aged; Ophthalmoplegia

Two patients with progressive rubella panencephalitis, one with and one without stigmata of congenital rubella, were treated for 9 months with isoprinosine and showed continued clinical deterioration. Immunoviorological studies performed before, during and after treatment were unaffected by drug therapy. The virus was recovered on one occasion from the lymphocytes of one of these cases. Neither patient showed any major defects in cellular or humoral immunity. However, the lymphocytes of the patient with stigmata of congenital rubella failed to respond to rubella virus in vitro and had a heat stable, non-dialysable serum inhibitor of in vitro protein A stimulated proliferative responses. Both patients' serum interfered with the production of interferon by normal donor lymphocytes following stimulation with rubella and varicella virus antigen. Increasing serum titres of interferon which did not appear to be lymphoid or immune-specific in origin were found in these two cases.

Topics: Adolescent; Adult; Encephalitis; Humans; Immunity, Cellular; Inosine; Inosine Pranobex; Interferons; Lymphocytes; Lymphokines; Male; Mitogens; Mitosis; Rubella

This report describes the clinical course of a 16-year-old Canadian-born Chinese boy who has progressive rubella panencephalitis. The progression, the lack of response to 'Isoprenosine', and the additional finding of myopathy are discussed. The clinical and pathological features of this rare, progressive neurological disorder are also summarized. In view of the last major rubella pandemic occuring in the mid-60s, it is likely that during the next few years physicians will diagnose an increased number of patients with this distinct neurological entity.

Topics: Adolescent; Antibodies, Viral; Complement Fixation Tests; Electrodiagnosis; Encephalitis; Hemagglutination Inhibition Tests; Humans; Inosine; Inosine Pranobex; Male; Rubella

Seven cases of confirmed or probable acute necrotizing herpes encephalitis (ANE) were studied using computer tomography during the various acute or chronic stages of the disease. They were bilateral, or in some rare patients, asymmetrical pseudofocal cases of ANE. Computer tomography appearances are described from the morphological and topographical point of view, before and after intravenous injection of a contrast medium. Analogous data reported in the published literature is used to describe the findings and to emphasize the problem of differential diagnosis. Computer tomography appears to be an essential examination for establishing the diagnosis and prognosis in herpes encephalitis, but it must be correlated with the results of an electro-encephalogram, and biological and immunological tests of the cerebrospinal fluid. It can also be of value for choosing the optimal site for urgent cerebral biopsy with immunofluorescence. Treatment must be given very early, whether Ara A antiviral DNA or Isoprinosine (Inosiplex) which stimulates cellular immunity, as soon after diagnosis has been established as possible. The authors chose the latter medication for 6 of the 7 cases reported, as well as in 12 other cases of acute primary viral encephalitis, and 3 cases of subacute sclerozing panencephalitis, and obtained very positive results.

Topics: Adolescent; Adult; Encephalitis; Female; Herpesviridae Infections; Humans; Inosine; Inosine Pranobex; Male; Middle Aged; Tomography, X-Ray Computed