inosine-pranobex and Disease-Models--Animal

inosine-pranobex has been researched along with Disease-Models--Animal* in 2 studies

Other Studies

2 other study(ies) available for inosine-pranobex and Disease-Models--Animal

Article	Year
Behavior of haptoglobin in experimental allergic encephalomyelitis in chickens. Archivum immunologiae et therapiae experimentalis, 1985, Volume: 33, Issue:6 Concentration of haptoglobin (Hpc) in serum of chickens with inflammation and allergic encephalomyelitis (EAE) was determined. Chickens with aseptic inflammatory state revealed 2.5 times higher concentration of Hpc while in the course of EAE only small increase was observed. Administration of immunomodulator--isoprinosine, resulted in elevation of Hpc level as compared to nontreated chickens. Topics: Animals; Chickens; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Haptoglobins; Inflammation; Inosine Pranobex	1985
Isoprinosine as an immunopotentiator in an animal model of human osteosarcoma. International journal of immunopharmacology, 1981, Volume: 3, Issue:4 The effects of isoprinosine (ISO) on the immune responses (Con A-induced lymphocyte proliferation, monocyte chemotactic responsiveness, and "natural killer" cytotoxicity) of normal hamsters and hamsters with human osteosarcoma (OS) were investigated. Human osteosarcoma was induced in newborn inbred hamsters (LHX/SsLAK) after induction of tolerance in utero. In vitro, ISO increased Con A-induced proliferation of peripheral blood lymphocytes (PBL) from normal hamsters by 23.4-48.9% and from OS-bearing hamsters by 58.1-107.4% over controls (Con A alone). When ISO was administered in vivo by intraperitoneal injection. Con A-induced proliferation of PBL from both normal and OS-bearing recipients in vitro was increased by 50-55% at 1, 3 and 5 days after injection. The chemotactic responsiveness of monocytes from OS-bearing hamsters was also significantly increased (59.1-97.4%) at 1, 3 and 5 days after injection of ISO. Natural killer cytotoxicity was augmented at 1, 3 and 5 days after injection of ISO by 31.7-83.6% in normal hamsters and 54.6-184% in OS-bearing hamsters. These results indicate that ISO can produce a generalized enhancement of immune function in hamsters with OS. Topics: Adjuvants, Immunologic; Animals; Chemotaxis, Leukocyte; Concanavalin A; Cricetinae; Cytotoxicity, Immunologic; Disease Models, Animal; Female; Humans; In Vitro Techniques; Inosine; Inosine Pranobex; Lymphocyte Activation; Osteosarcoma; Pregnancy; Sarcoma, Experimental	1981

Article

Year

Behavior of haptoglobin in experimental allergic encephalomyelitis in chickens.

Archivum immunologiae et therapiae experimentalis, 1985, Volume: 33, Issue:6

Concentration of haptoglobin (Hpc) in serum of chickens with inflammation and allergic encephalomyelitis (EAE) was determined. Chickens with aseptic inflammatory state revealed 2.5 times higher concentration of Hpc while in the course of EAE only small increase was observed. Administration of immunomodulator--isoprinosine, resulted in elevation of Hpc level as compared to nontreated chickens.

Topics: Animals; Chickens; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Haptoglobins; Inflammation; Inosine Pranobex

1985

Isoprinosine as an immunopotentiator in an animal model of human osteosarcoma.

International journal of immunopharmacology, 1981, Volume: 3, Issue:4

The effects of isoprinosine (ISO) on the immune responses (Con A-induced lymphocyte proliferation, monocyte chemotactic responsiveness, and "natural killer" cytotoxicity) of normal hamsters and hamsters with human osteosarcoma (OS) were investigated. Human osteosarcoma was induced in newborn inbred hamsters (LHX/SsLAK) after induction of tolerance in utero. In vitro, ISO increased Con A-induced proliferation of peripheral blood lymphocytes (PBL) from normal hamsters by 23.4-48.9% and from OS-bearing hamsters by 58.1-107.4% over controls (Con A alone). When ISO was administered in vivo by intraperitoneal injection. Con A-induced proliferation of PBL from both normal and OS-bearing recipients in vitro was increased by 50-55% at 1, 3 and 5 days after injection. The chemotactic responsiveness of monocytes from OS-bearing hamsters was also significantly increased (59.1-97.4%) at 1, 3 and 5 days after injection of ISO. Natural killer cytotoxicity was augmented at 1, 3 and 5 days after injection of ISO by 31.7-83.6% in normal hamsters and 54.6-184% in OS-bearing hamsters. These results indicate that ISO can produce a generalized enhancement of immune function in hamsters with OS.

Topics: Adjuvants, Immunologic; Animals; Chemotaxis, Leukocyte; Concanavalin A; Cricetinae; Cytotoxicity, Immunologic; Disease Models, Animal; Female; Humans; In Vitro Techniques; Inosine; Inosine Pranobex; Lymphocyte Activation; Osteosarcoma; Pregnancy; Sarcoma, Experimental

1981