inosine-pranobex and Chickenpox

Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Chickenpox; Child; Encephalitis; Enterovirus Infections; Female; Herpesviridae Infections; Humans; Hypnotics and Sedatives; Influenza, Human; Inosine Pranobex; Male; Measles; Mumps; Rubella; Virus Diseases

Topics: Amantadine; Animals; Benzimidazoles; Chickenpox; Cytarabine; gamma-Globulins; Hepatitis, Viral, Human; Herpes Simplex; Herpes Zoster; Humans; Idoxuridine; Inosine Pranobex; Interferons; Measles; Mumps; Phosphonoacetic Acid; Ribavirin; Rifampin; Rubella; Vaccination; Vaccinia virus; Vidarabine; Virus Diseases

The therapeutic effect of isoprinosine and acyclovir have been studied in 352 and 284 patients with chicken-pox and herpes zoster respectively. The patients were divided into 4 groups: the first one was given palliative treatment only, the second--both palliative and isoprinosine ones, the third--palliative and acyclovir treatment, and the fourth group was given all these. The best therapeutic effect was achieved when acyclovir and isoprinosine was applied jointly, the one of acyclovir alone was less pronounced and that of isoprinosine only was the smallest. According to the authors acyclovir should be the treatment of choice in the very severe and severe cases of chicken-pox and herpes zoster; in the early stage of disease it should be supplemented with isoprinosine and passive immunotherapy.

Topics: Acyclovir; Administration, Oral; Adolescent; Adult; Aged; Chickenpox; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Herpes Zoster; Humans; Injections, Intravenous; Inosine Pranobex; Male; Middle Aged; Remission Induction; Time Factors