inosine-diphosphate and Skin-Diseases

To study the role of free radical processes (FRP) in the development of involutional skin changes and their correction.. One hundred and twenty patients aged 18 to 74 years with various degrees of involutional facial and cervical skin changes were examined. Clinical and laboratory assessments were made over time. The oxygen and lipid peroxidase parameters of FRP were estimated; objective and subjective visualization, Doppler flowmetry of the facial skin, and colorimetric study of the skin color spectrum were done.. The imbalance between oxygen and lipid peroxide components of FRP was found to increase with advancing age. These processes correlate with the severity of involutional skin changes and objectify the early use of energy-correcting therapy (ECT). The incorporation of ECT with cytoflavin positively affects FRP values and clinical and instrumental findings of involutional facial and cervical skin changes, by improving microcirculation. The patients with first-second degree involutional skin changes achieved the best results.. The findings permit cytoflavin to be recommended as one of the components of therapy aimed to stabilize intradermal exchange processes as part cosmetic manipulations in aesthetic medicine.

Topics: Adolescent; Adult; Age Factors; Aged; Colorimetry; Drug Combinations; Face; Female; Flavin Mononucleotide; Free Radicals; Humans; Inosine Diphosphate; Laser-Doppler Flowmetry; Lipid Peroxides; Middle Aged; Neck; Niacinamide; Oxygen; Severity of Illness Index; Skin Diseases; Succinates; Treatment Outcome; Vitamin B Complex; Young Adult

Based on the literature data and their own findings, the authors give grounds for the use of phosphaden, riboxin, and dipromonium in psoriasis, eczema, and atrophic lichen. Prospects in the application of vitamin synthetic analogues and of coenzymic preparations are shown.

Topics: Adenosine Monophosphate; Adult; Dermatologic Agents; Energy Metabolism; Female; Humans; Inosine Diphosphate; Inosine Nucleotides; Male; Middle Aged; Quaternary Ammonium Compounds; Skin Diseases