inosine-diphosphate and Postoperative-Complications

An evaluation of cognitive functions was presented in 90 patients undergoing thyroid surgery. An attention deterioration, shot-term memory impairment and degradation were revealed after operation. It was shown that reduction of manifestations of cognitive dysfunction and stabilization of the haemodynamics indices were allowed due to application of cytoflavin during operation and in early postoperative period.

Topics: Cognition; Cognition Disorders; Dose-Response Relationship, Drug; Drug Combinations; Female; Flavin Mononucleotide; Follow-Up Studies; Humans; Hyperparathyroidism; Imidazoles; Inosine Diphosphate; Niacinamide; Postoperative Complications; Prognosis; Prospective Studies; Succinates; Tetrazoles; Thyroidectomy

Topics: Assisted Circulation; Cognition; Cognition Disorders; Drug Combinations; Female; Flavin Mononucleotide; Heart Valve Diseases; Humans; Inosine Diphosphate; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Postoperative Complications; Succinates; Treatment Outcome

The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level. The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation, shorter time of staying in critical condition, more favorable course of complications.

Topics: Adult; Antioxidants; Drug Combinations; Endotoxemia; Female; Flavin Mononucleotide; Free Radicals; Humans; Inosine Diphosphate; Male; Middle Aged; Niacinamide; Peritonitis; Postoperative Complications; Postoperative Period; Succinates

To study the effectiveness of the inclusion of Cytoflavin in the management of postoperative delirium treating in elderly patients. Analyzed the results of treatment of 89 elderly patients (65-74 years) who, according to similar emergency indications, underwent surgery and postoperatively showed signs of delirium (according to the DDS scale ≥8 points). Depending on the treatment regimen, the patients were divided into three groups: in the first (n=32) group, bromodihydrochlorophenylbenzodiazepine was administered intravenously (1-5 min) in a dose of 1 mg in the 1st group (n=32) to the group (patients of the 2nd group (n=28) with the same purpose and at the same time cytoflavin was injected: 10 ml of the drug in dilution per 200 ml of 10% glucose solution intravenously at a rate of 140 drops (7 ml) per minute. Patients of 3rd group (n=29) were injected with ethylmethylhydroxypyridine succinate intravenous (within 5-7 min) at a dose of 200 mg. The condition was assessed using the SOFA, DDS and RASS scales. The inclusion of drugs with antioxidant/membrane-protective action (Cytoflavin and ethylmethylhydroxypyridine succinate) in the treatment regimen of postoperative delirium in the elderly increases the effectiveness of treatment, which is manifested in more rapid relief of the condition. When comparing the efficacy of Cytoflavin and ethylmethylhydroxypyridine succinate, it was noted that in a number of indicators (restoration of spontaneous breathing, improvement after the first dose and complete relief of signs of delirium) both drugs showed comparable results, however, when assessing the depth of sedation (on the RASS scale), Cytoflavin was more effective (p=0,001).The obtained results of the effectiveness of cytoflavin in combination with good patient tolerance allows us to recommend the inclusion of the drug in the treatment regimens of this pathology.. Изучена эффективность включения препарата «Цитофлавин» в схемы купирования послеоперационного делирия у пациентов пожилого возраста. Проанализированы результаты терапии 89 пациентов пожилого возраста (65–74 года), которым по сходным экстренным показаниям было проведено оперативное вмешательство, и в послеоперационном периоде были отмечены признаки делирия (по шкале DDS ≥8 баллов). В зависимости от схемы терапии пациенты были разделены на три группы. В 1-й группе (n=32) для купирования делирия вводили бромдигидрохлорфенилбензодиазепин внутривенно в дозе 1 мг струйно (в течение 5–7 мин); пациентам 2-й группы (n=28) с той же целью и в те же сроки вводили Цитофлавин: 10 мл препарата в разведении на 200 мл 10% раствора глюкозы внутривенно капельно со скоростью 140 капель (7 мл) в мин. Больным 3-й группы (n=29) вводили этилметилгидроксипиридина сукцинат в дозе 200 мг внутривенно струйно (в течение 5–7 мин). Состояние оценивали с помощью шкал SOFA, DDS и RASS. Включение в схемы терапии постоперационного делирия у пожилых людей препаратов с антиоксидантным/мембранопротекторным действием (Цитофлавина и этилметилгидроксипиридина сукцината) повышает эффективность лечения, что проявляется в более быстром купировании состояния. При сравнении эффективности Цитофлавина и этилметилгидроксипиридина сукцината было отмечено, что по ряду показателей (восстановление спонтанного дыхания, улучшение состояния после введения первой дозы и полное купирование признаков делирия) оба препарата показали сопоставимые результаты, однако при оценке глубины седации (по шкале RASS) Цитофлавин был более эффективен (р=0,001). Полученные результаты эффективности Цитофлавина в сочетании с хорошей переносимостью позволяют рекомендовать включение препарата в схемы лечения пациентов с данной патологией.

Topics: Aged; Antioxidants; Delirium; Drug Combinations; Flavin Mononucleotide; Humans; Inosine Diphosphate; Niacinamide; Postoperative Complications; Pyridines; Succinates

The objective of the research was to develop and evaluate the algorithm of prevention and treatment of postoperative hypoparathyroidism (PHPT) based on determining parathyroid glands (PTG) viability and the use of antihypoxant-antioxidant therapy in the postoperative period. The research was based on the results of a comprehensive examination and treatment of 60 patients who were operated for thyroid gland diseases. The patients underwent inpatient treatment at the surgical department of Ivano-Frankivsk Central City Clinical Hospital and Ivano-Frankivsk Regional Oncology Center from 2015 to 2017. We proposed an algorithm for surgical prevention and treatment of PHPT during thyroid gland surgeries which consisted in the following. We performed a visual assessment of PTG intraoperatively and evaluated each gland from 0 to 3 points according to the degree of its viability affection. If the gland was evaluated at 0-2 points, we left it in situ, since there was a high probability of maintaining its function. If it was evaluated at 3 points, its autotransplantation was performed. Cytoflavin drug was applied in a dose of 10 ml per 200 0.9% NaCl intravenously once a day during 7 days in the postoperative period for the purpose of antihypoxant-antioxidant therapy. 2 groups of patients were formed in order to evaluate the effectiveness of the algorithm. Each group consisted of 30 people. Patients of Group I underwent surgery on thyroid gland according to generally accepted rules. Patients of Group II underwent interventions according to the above-mentioned algorithm. The use of our proposed algorithm (intraoperative assessment of PTG viability and antihypoxant-antioxidant therapy in the postoperative period) significantly reduces the frequency of permanent PHPT justifying indications to its application.

Topics: Antioxidants; Drug Combinations; Flavin Mononucleotide; Humans; Hypoparathyroidism; Hypoxia; Inosine Diphosphate; Middle Aged; Niacinamide; Parathyroid Glands; Postoperative Complications; Succinates; Thyroid Diseases

The aim of the study is to formulate the tactics of assigning adequate neuroprotective therapy to patients with postoperative cognitive dysfunctions on the basis of subtracting the indicator of the total cognitive deficiency. To achieve this goal, we conducted a study of cognitive function in patients of different age groups: young age, middle age, elderly age with acute surgical pathology before surgery and at 1, 7, 30 days after surgery compared with preoperative data. Methods of research. The study of the cognitive sphere: scale MMSE, test drawing hours, test "10 words", battery tests for frontal dysfunction, method Schulte. The indicator of the total cognitive deficiency was calculated.  The results of the study of cognitive function made it possible to formulate a scheme for the use of citicoline and cytoflavin in a complex of therapeutic programs. In each age group, on the seventh day of the study, there were patients with different dynamics of cognitive function recovery for the preoperative period. This allowed us to develop and propose a formula for calculating the total cognitive deficit, which makes it possible to formulate appropriate tactics for managing patients in the subsequent period in each specific case. We determine the values ​​of the percentage deviations of each study result from the norm and the indicator of the total cognitive deficit by the sum of the values ​​of the percentage deviation from the norm of the results of the study of cognitive impairment.

Topics: Adult; Age Factors; Aged; Aged, 80 and over; Cognition Disorders; Cytidine Diphosphate Choline; Drug Combinations; Flavin Mononucleotide; Humans; Inosine Diphosphate; Neuroprotective Agents; Neuropsychological Tests; Niacinamide; Postoperative Complications; Psychometrics; Succinates

The cardiac surgery is accompanied by multifactorial alteration of the brain, which can present in different clinical types of postoperative cerebral dysfunction. A stroke was diagnosed only after coronary artery bypass graft surgery with cardiopulmonary bypass. Postoperative cognitive dysfunction (including acute cognitive dysfunction and deferred cognitive impairment) was significantly more frequent after surgery with cardiopulmonary bypass. The preoperative use of complex cytoprotective medication Cytoflavin decreased the severity of the deferred cognitive impairment. The data show the prospects of the pharmacological neuroprotection in cardiac surgery with cardiopulmonary bypass.

Topics: Aged; Brain Diseases; Cardiopulmonary Bypass; Cognitive Dissonance; Drug Combinations; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; Male; Middle Aged; Neuroprotective Agents; Niacinamide; Postoperative Complications; Succinates

The cognitive functions assessment in 68 patients operated on thyroid gland is presented. It is elicited that attention decrease, short-term memory upset, depressed work-capacity develop after intervention. It is shown that cytoflavin use within the intervention and early postoperative period permit to decrease cognitive dysfunction signs.

Topics: Adolescent; Adult; Aged; Antioxidants; Cognition Disorders; Drug Combinations; Drug Monitoring; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; Intraoperative Care; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Niacinamide; Postoperative Care; Postoperative Complications; Recovery of Function; Succinates; Thyroid Diseases; Thyroid Gland; Thyroidectomy; Treatment Outcome