inosine-diphosphate and Periodontitis

inosine-diphosphate has been researched along with Periodontitis* in 2 studies

Trials

2 trial(s) available for inosine-diphosphate and Periodontitis

ArticleYear
[The effectiveness of the combined use of energomonitor antioxidant and cognitive psychotherapy in the treatment of generalized periodontitis in elderly patients].
    Stomatologiia, 2016, Volume: 95, Issue:2

    The aim of the study was to evaluate the effect of combined use of Cytoflavin and cognitive therapy on the dynamics of psychosomatic status and effectiveness of the treatment of generalized periodontitis in elderly patients. The results of treatment of 103 patients aged 60 and older were analyzed. All patients received standard therapy for 10-14 days depending on the severity of the process. In addition, the patients of the main group (51 patients) received Cytoflavin: 2 tabs. 2 times a day with an interval between doses of 8-10 hours for 25 days, and cognitive therapy aimed at training alternative realistic way of life perception. Treatment results were monitored by PMA, Russell periodontal index (PI), Green-Vermillion hygienic index. Psychosomatic dynamics was assessed by means of Spielberger anxiety scale and SUN" methods of before and after a month of treatment. The inclusion in the treatment regimen of Cytoflavin and cognitive therapy had a positive impact: reduction of PMA by 61.8%, PI by 45.3% and Green-Vermillion index by 39.8%. The psychosomatic tests proved anxiety level decrease by 28.7% in terms of "reactive" anxiety and 31.5% in terms of "personal" anxiety, emotional status (21.2%), activity (21.7%) and mood (21.8%) improvement.. Цель исследования - оценка влияния сочетанного использования цитофлавина и когнитивной психотерапии на динамику психосоматического статуса и эффективность лечения генерализованного пародонтита у пациентов пожилого возраста. Для этого были проанализированы результаты лечения 103 пациентов в возрасте 60 лет и старше. Все пациенты получали стандартную терапию в течение 10-14 дней в зависимости от тяжести процесса. Кроме того, пациентам основной группы (51 больной) назначался цитофлавин по схеме: 2 таблетки 2 раза в сутки с интервалом между приемами 8-10 ч в течение 25 дней и когнитивная психотерапия, направленная на обучение альтернативному, реалистичному способу восприятия жизни. Для мониторинга результатов лечения проводилось тестирование: клинического состояния по шкалам РМА, PI Рассела и гигиеническому индексу Грина-Вермильона и психосоматического - по шкале тревоги Спилбергера и методике 'САН' в динамике - до и через месяц после начала лечения. Включение в схемы лечения цитофлавина и когнитивной психотерапии оказало положительное влияние: отмечено снижение РМА на 61,8%, пародонтального индекса на 45,3% и гигиенического индекса Грина-Вермильона на 39,8% а также улучшение психосоматического статуса: снижение уровня тревожности на 28,7% по показателю 'реактивной' тревожности и на 31,5% - по показателю 'личностной' тревожности, и улучшение самочувствия на 21,2%, активности - на 21,7%, настроения - на 21,8%.

    Topics: Aged; Aged, 80 and over; Antioxidants; Cognitive Behavioral Therapy; Combined Modality Therapy; Drug Combinations; Flavin Mononucleotide; Humans; Inosine Diphosphate; Middle Aged; Niacinamide; Periodontitis; Succinates; Treatment Outcome

2016
[Oxidative stress and combined antioxidant energy correction in the treatment of periodontitis].
    Stomatologiia, 2011, Volume: 90, Issue:1

    Experimental-clinical study with inclusion of 50 Wistar rats with modeled parodontitis and 71 patients with chronic generalized parodontitis of different severity degree was conducted. Significance of oxidation stress in disease development and running was established in the course of the study. Disbalance of free-radical processes (FRP) in case of periodontal diseases affects oxygen stage of the oxidation stress in bigger degree and continues for a long time. In the course of experiment positive influence of cytoflavine preparation as energy-correction and antioxidant was confirmed as well as its combination with calcium-D3. In the course of comprehensive clinical study the efficacy of cytoflavine use was verified by the example of FRP correction that was accompanied by clinical picture and treatment results improvement.

    Topics: Adult; Aged; Animals; Antioxidants; Calcium; Cholecalciferol; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Energy Metabolism; Female; Flavin Mononucleotide; Free Radicals; Humans; Inosine Diphosphate; Male; Middle Aged; Niacinamide; Oxidative Stress; Periodontitis; Rats; Rats, Wistar; Succinates

2011