inosine-diphosphate and Myocardial-Infarction

The effect of cytoflavin on parameters of the left ventricular systolic function (LVSF) during acute myocardial infarction was studied in a group of 46 patients which received this drug (in addition to standard therapy) intravenously as 20 mL of Polysan solution (St. Petersburg, Russia) diluted in 250 mL of 5% glucose solution once a day 30 min before coronary artery recanalization. The control group of 60 patients received only standard therapy. The drug effectiveness was evaluated in terms of LVSF parameters including the ejection fraction, end-diastolic volume, and end-systolic volume. The introduction of cytoflavin to pati- ents led to (i) increase in the ejection fraction of left ventricle by 7.9% as compared to patients of the control group and (ii) decrease in the end-diastolic and end-systolic volume of the left ventricle on 7th day of hospitalization by 10.6% and 17.9%, respectively (p < 0.05). The addition of cytoflavin to standard the- rapy significantly reduced the level of troponin I on the 7th day in patients with acute myocardial infarction down to 81% relative to the control and the activity of creatine kinase by 35% (p < 0.05). The inclusion of cytoflavin in the treatment of patients with acute myocardial infarction should be considered as pathoge- netically proved, clinically justified, and promising therapy.

Topics: Adult; Aged; Biomarkers; Cardiotonic Agents; Case-Control Studies; Coronary Vessels; Creatine Kinase; Drug Administration Schedule; Drug Combinations; Female; Flavin Mononucleotide; Gene Expression; Heart Ventricles; Humans; Inosine Diphosphate; Male; Middle Aged; Myocardial Infarction; Niacinamide; Stents; Stroke Volume; Succinates; Systole; Treatment Outcome; Troponin I; Ventricular Function, Left

Peptide CH3CO-Lys-Lys-Arg-Arg-NH2 (protectin) was synthesized and its activity was studied on the model of experimental myocardial infarction in rats in comparison to the reference antihypoxant drug riboxin. Intranasal injections ofprotectin at doses within 2-20 microg/kg once a day by course of 7 days produced a pronounced anti-ischemic action, improved coronary circulation of the blood, increases contractile activity of myocardium, reduced intensity of lipid peroxidation, and improved antioxidant protection. In some respects (improved coronary circulation of the blood, increased antioxidant protection), protectin was more effective than riboxin.

Topics: Administration, Intranasal; Animals; Antioxidants; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Inosine Diphosphate; Lipid Peroxidation; Male; Myocardial Infarction; Oligopeptides; Rats; Rats, Sprague-Dawley

Results of the evaluation of clinical findings in a group of 36 patients with acute myocardial infarction (AMI) complicated by acute heart failure (AHF) of class II - IV [according to T. Killip and J. Kimball (1967)] show that the use of cytoflavin and perftoran favors a decrease in the patient critical situation length, duration of patient's stay in hospital, and lethality level. It is established that these drugs lead to a decrease in the depth of hypoxia and lipid peroxidation in tissues, improves oxygen utilization, and restores antioxidant system activity in AMI/AHF patients.

Topics: Acute Disease; Critical Care; Drug Combinations; Flavin Mononucleotide; Fluorocarbons; Free Radicals; Heart Failure; Humans; Hypoxia; Inosine Diphosphate; Inpatients; Length of Stay; Lipid Peroxidation; Myocardial Infarction; Niacinamide; Succinates

A study is presented of the carbohydrate energy metabolism and processes of peroxidation in rats with experimental pitutrin-isadrin myocardial infarction. Essential changes of these values were noted. It is concluded that quinasopyrin and preparation E normalize to a greater extent and riboxin to a smaller extent metabolic disorders in the ischemia-involved myocardium tissues.

Topics: Animals; Cardiovascular Agents; Drug Evaluation, Preclinical; Heart; Inosine Diphosphate; Inosine Nucleotides; Isoproterenol; Male; Myocardial Infarction; Myocardium; Pituitary Hormones, Posterior; Quinazolines; Rats; Rats, Inbred Strains

A study of 64 patients with acute myocardial infarction revealed an elevated concentration of peroxidation radicals in the blood, a reduction of the antioxidant system. Three hours after i/v administration of riboxin the content of peroxidation radicals reduced. After discontinuation of intravenous riboxin peroxidation of lipids increased again.

Topics: Adult; Aged; Drug Evaluation; Female; Free Radicals; Humans; Inosine Diphosphate; Inosine Nucleotides; Lipid Peroxidation; Male; Middle Aged; Myocardial Infarction; Time Factors