inosine-diphosphate and Hypoxia

The article deals with the materials, which have been received in the process of the examination and treatment of 48 patients with acute severe carbon monoxide and burning products poisonings on fires. It has been registered that the including of citoflavin into the complex program of the intensive therapy of acute severe carbon monoxide and burning products poisonings on fires leads to a decrease of hypoxia and manifestations of acute toxicohypoxic cerebral deficiency, which significantly improves the clinics of acute severe poisonings.

Topics: Acute Disease; Adult; Blood Gas Analysis; Carbon Monoxide Poisoning; Combined Modality Therapy; Critical Care; Drug Combinations; Drug Therapy, Combination; Female; Fires; Flavin Mononucleotide; Humans; Hypoxia; Hypoxia, Brain; Inosine Diphosphate; Male; Neuroprotective Agents; Niacinamide; Oxygen; Respiration, Artificial; Succinates; Treatment Outcome

Results of an analysis of the efficiency of using cytoflavin, a drug possessing cytoprotective and antihypoxemic properties, in a group of 215 patients with a diagnosis of acute carbon monoxide poisoning in 2004-2010 are compared to analogous data for 215 patients with same diagnosis treated in 1999-2004 without cytoflavin administration. It is established that timely application of cytoflavin (against the standard treatment of CO poisoning) favored lower expressiveness of post-hypoxemic encephalopathythatis characteristic of the given pathology.

Topics: Adult; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhemoglobin; Case-Control Studies; Drug Administration Schedule; Drug Combinations; Female; Flavin Mononucleotide; Humans; Hypoxia; Infusions, Intravenous; Inosine Diphosphate; Male; Middle Aged; Neuroprotective Agents; Niacinamide; Retrospective Studies; Russia; Severity of Illness Index; Succinates; Survival Rate; Unconsciousness

The objective of the research was to develop and evaluate the algorithm of prevention and treatment of postoperative hypoparathyroidism (PHPT) based on determining parathyroid glands (PTG) viability and the use of antihypoxant-antioxidant therapy in the postoperative period. The research was based on the results of a comprehensive examination and treatment of 60 patients who were operated for thyroid gland diseases. The patients underwent inpatient treatment at the surgical department of Ivano-Frankivsk Central City Clinical Hospital and Ivano-Frankivsk Regional Oncology Center from 2015 to 2017. We proposed an algorithm for surgical prevention and treatment of PHPT during thyroid gland surgeries which consisted in the following. We performed a visual assessment of PTG intraoperatively and evaluated each gland from 0 to 3 points according to the degree of its viability affection. If the gland was evaluated at 0-2 points, we left it in situ, since there was a high probability of maintaining its function. If it was evaluated at 3 points, its autotransplantation was performed. Cytoflavin drug was applied in a dose of 10 ml per 200 0.9% NaCl intravenously once a day during 7 days in the postoperative period for the purpose of antihypoxant-antioxidant therapy. 2 groups of patients were formed in order to evaluate the effectiveness of the algorithm. Each group consisted of 30 people. Patients of Group I underwent surgery on thyroid gland according to generally accepted rules. Patients of Group II underwent interventions according to the above-mentioned algorithm. The use of our proposed algorithm (intraoperative assessment of PTG viability and antihypoxant-antioxidant therapy in the postoperative period) significantly reduces the frequency of permanent PHPT justifying indications to its application.

Topics: Antioxidants; Drug Combinations; Flavin Mononucleotide; Humans; Hypoparathyroidism; Hypoxia; Inosine Diphosphate; Middle Aged; Niacinamide; Parathyroid Glands; Postoperative Complications; Succinates; Thyroid Diseases

This study was aimed at determining the influence of cytoflavin on the morphological features of contractile cardiomyocytes in female rats after gestation and in newborn rats exposed to hemic hypoxia induced by sodium nitrite (NaNO(2)). The experiment was performed on 28 three-month-old female Wistar albino rats and their offspring (24 seven-day-old newborns). Throughout pregnancy and during 7 days of suckling period, all animals divided into two groups were daily injected intraperitoneally with NaNO(2) at a dose of 5 mg/100 g body weight. Animals in the second test group were additionally injected intraperitoneally with. cytoflavin at a dose of 0.5 mL/100 g body weight. It was found that hemid hypoxia had a strong pathogenic effect on the contractile cardiomyocytes and hemomicrocirculatory bed vessels, which was manifested by the hypoxic and ischernic damage involving violation of the integrity of cellular and mitochondrial membranes. Histological and morphometric studies in animals of the first group showed a significant decrease in the length and area of contractile cardiomyocytes: up to 16.9 and 36.04%, respectively (p = 0.05). In the second group of animals (treated with cytoflavin), these changes were less pronounced: reduction in length and area on the average was 8.2 and 18.6%, respectively (p = 0.05). The administration of cytoflavin reduces the degree of cardiomyocyte damage in female rats after gestation and in newborns, presumably due to the antioxidant and membrane-protective properties of this drug.

Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Female; Flavin Mononucleotide; Hypoxia; Inosine Diphosphate; Myocardium; Myocytes, Cardiac; Niacinamide; Rats; Sodium Nitrite; Succinates

Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of IIIB degree (20% of body surface) against early introduction of antihypoxants reamberin and cytoflavin. It is established that the introduction of antihypoxants reliably prevents the development of typical pathologic processes and hypoxemia, reduces expressiveness of organ dysfunction and extent of mophological changes in internal organs, and increases 1.5 - 2.5 times the survival rate of heavily damaged animals in the acute period of burn injury.

Topics: Acute Disease; Animals; Burns; Drug Combinations; Drug Evaluation, Preclinical; Female; Flavin Mononucleotide; Hypoxia; Inosine Diphosphate; Male; Meglumine; Niacinamide; Rats; Succinates

We studied the development of metabolic disorders related to tissue hypoxia in 54 patients with acute severe asaleptin intoxication complicated by acute respiratory insfficiency of mixed genesis. We also estimated the role of a substrate antihypoxant cytoflavin in the correction of these disorders and clinical features of acute intoxication. Cyroflavin was shown to accelerate normalization of metabolic disorders which in turn improves clinical symptoms of severe forms of acute asaleptin intoxication.

Topics: Acute Disease; Adult; Antipsychotic Agents; Clozapine; Drug Combinations; Female; Flavin Mononucleotide; Humans; Hypoxia; Inosine Diphosphate; Male; Metabolic Diseases; Middle Aged; Niacinamide; Respiratory Insufficiency; Severity of Illness Index; Succinates; Young Adult

Topics: Adult; Aged; Anesthesia, General; Dose-Response Relationship, Drug; Drug Combinations; Female; Flavin Mononucleotide; Follow-Up Studies; Gynecologic Surgical Procedures; Humans; Hypoxia; Infusions, Intravenous; Inosine Diphosphate; Malondialdehyde; Middle Aged; Neoplasms; Niacinamide; Postoperative Period; Succinates; Treatment Outcome

Results of the evaluation of clinical findings in a group of 36 patients with acute myocardial infarction (AMI) complicated by acute heart failure (AHF) of class II - IV [according to T. Killip and J. Kimball (1967)] show that the use of cytoflavin and perftoran favors a decrease in the patient critical situation length, duration of patient's stay in hospital, and lethality level. It is established that these drugs lead to a decrease in the depth of hypoxia and lipid peroxidation in tissues, improves oxygen utilization, and restores antioxidant system activity in AMI/AHF patients.

Topics: Acute Disease; Critical Care; Drug Combinations; Flavin Mononucleotide; Fluorocarbons; Free Radicals; Heart Failure; Humans; Hypoxia; Inosine Diphosphate; Inpatients; Length of Stay; Lipid Peroxidation; Myocardial Infarction; Niacinamide; Succinates

Cerebronorm prevents de-energization of mitochondria, limitation of succinate- and NAD-dependent energy production, and oxidation-phosphorylation uncoupling and inhibits LPO processes in the brain of rats under conditions of hypoxia.

Topics: Animals; Brain; Energy Metabolism; Hypoxia; Inosine Diphosphate; Lipid Peroxidation; Male; Mitochondria; Niacinamide; Oxidative Phosphorylation; Rats; Riboflavin; Succinic Acid

Topics: Adult; Aged; Female; Heart Failure; Humans; Hypoxia; Inosine Diphosphate; Inosine Nucleotides; Male; Middle Aged; Oxidative Phosphorylation; Oxygen Consumption; Oxyhemoglobins