inosine-diphosphate and Hypoxia-Ischemia--Brain

inosine-diphosphate has been researched along with Hypoxia-Ischemia--Brain* in 3 studies

Trials

2 trial(s) available for inosine-diphosphate and Hypoxia-Ischemia--Brain

Article	Year
[Current approaches to cerebroprotective treatment of premature newborns in reanimation and intensive care departments]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:1 This work was conducted in the frames of a multicenter clinical trial. The aim was to study efficacy of cytoflavin (infusion solution) in the prevention and treatment of posthypoxic CNS lesions in premature newborns. The study included 120 premature newborns (gestation period 28-36 weeks) who was born in severe distress and needed the intensive therapy after primary reanimation measures. Cytoflavin was prescribed in the first 2-4 h after the delivery to 61 newborns. The control group included 59 newborns who did not receive the drug. To assess treatment efficacy, the determination of some plasma neurospecific proteins (GFAP, NSE, MBP) was carried out along with standard clinical/instrumental and laboratory monitoring. The results revealed the marked cerebroprotective effect of cytoflavin. The significantly higher rate of normalization of KOC, pO2, PCO2 and elimination of lactate acidosis that led to the reduction of severity and frequency of ischemic and hemorrhagic CNS lesions as well as lower levels of plasma neurospecific proteins were seen in the main group compared to the control one. Topics: Drug Combinations; Female; Fetal Hypoxia; Flavin Mononucleotide; Glial Fibrillary Acidic Protein; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Inosine Diphosphate; Intensive Care Units, Neonatal; Intensive Care, Neonatal; Male; Myelin Basic Protein; Niacinamide; Resuscitation; Succinates; Treatment Outcome	2011
[Clinical-encephalographic evaluation of preterm children treated with cytoflavin during the first year of life]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:5 An aim of the study was the clinical and neurophysiological evaluation of the effect of cytoflavin and reanimation measures on the rate of nervous and mental development of preterm newborns with cerebral ischemia, II--III stage, during the first year of life. One hundred and twenty children with gestational age 28--36 weeks and body mass 1060-3150 g were studied. In the main group (n=61), the complex treatment included cytoflavin in dosage 2 ml/kg/day, intravenously during 5 days. The control group (n=59) received basic treatment without cytoflavin. The follow-up till the age of 1 year comprised the global assessment of state and neurological status using quantitative measurements of muscle postural tone on the INFANIB scale, psychomotor development (BSID-II) and assessment of CNS functional state by analyzing computed EEG signals during physiological sleep. The results obtained demonstrated the fast normalization of all studied measures of development of children treated with cytoflavin compared to those of the control group. Topics: Child Development; Drug Combinations; Electroencephalography; Female; Flavin Mononucleotide; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Infant, Premature; Inosine Diphosphate; Intensive Care, Neonatal; Male; Niacinamide; Psychomotor Disorders; Succinates	2011

Article

Year

[Current approaches to cerebroprotective treatment of premature newborns in reanimation and intensive care departments].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:1

This work was conducted in the frames of a multicenter clinical trial. The aim was to study efficacy of cytoflavin (infusion solution) in the prevention and treatment of posthypoxic CNS lesions in premature newborns. The study included 120 premature newborns (gestation period 28-36 weeks) who was born in severe distress and needed the intensive therapy after primary reanimation measures. Cytoflavin was prescribed in the first 2-4 h after the delivery to 61 newborns. The control group included 59 newborns who did not receive the drug. To assess treatment efficacy, the determination of some plasma neurospecific proteins (GFAP, NSE, MBP) was carried out along with standard clinical/instrumental and laboratory monitoring. The results revealed the marked cerebroprotective effect of cytoflavin. The significantly higher rate of normalization of KOC, pO2, PCO2 and elimination of lactate acidosis that led to the reduction of severity and frequency of ischemic and hemorrhagic CNS lesions as well as lower levels of plasma neurospecific proteins were seen in the main group compared to the control one.

Topics: Drug Combinations; Female; Fetal Hypoxia; Flavin Mononucleotide; Glial Fibrillary Acidic Protein; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Inosine Diphosphate; Intensive Care Units, Neonatal; Intensive Care, Neonatal; Male; Myelin Basic Protein; Niacinamide; Resuscitation; Succinates; Treatment Outcome

2011

[Clinical-encephalographic evaluation of preterm children treated with cytoflavin during the first year of life].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:5

An aim of the study was the clinical and neurophysiological evaluation of the effect of cytoflavin and reanimation measures on the rate of nervous and mental development of preterm newborns with cerebral ischemia, II--III stage, during the first year of life. One hundred and twenty children with gestational age 28--36 weeks and body mass 1060-3150 g were studied. In the main group (n=61), the complex treatment included cytoflavin in dosage 2 ml/kg/day, intravenously during 5 days. The control group (n=59) received basic treatment without cytoflavin. The follow-up till the age of 1 year comprised the global assessment of state and neurological status using quantitative measurements of muscle postural tone on the INFANIB scale, psychomotor development (BSID-II) and assessment of CNS functional state by analyzing computed EEG signals during physiological sleep. The results obtained demonstrated the fast normalization of all studied measures of development of children treated with cytoflavin compared to those of the control group.

Topics: Child Development; Drug Combinations; Electroencephalography; Female; Flavin Mononucleotide; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Infant, Premature; Inosine Diphosphate; Intensive Care, Neonatal; Male; Niacinamide; Psychomotor Disorders; Succinates

2011

Other Studies

1 other study(ies) available for inosine-diphosphate and Hypoxia-Ischemia--Brain

Article	Year
[Pharmacologic neuroprotection of the brain in carotid artery surgeries]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:6 Topics: Aged; Brain; Carotid Arteries; Carotid Stenosis; Drug Combinations; Endarterectomy, Carotid; Female; Flavin Mononucleotide; Heme; Humans; Hypoxia-Ischemia, Brain; Inosine Diphosphate; Male; Middle Aged; Neuroprotective Agents; Niacinamide; Reperfusion Injury; Succinates	2011

Article

Year

[Pharmacologic neuroprotection of the brain in carotid artery surgeries].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:6

Topics: Aged; Brain; Carotid Arteries; Carotid Stenosis; Drug Combinations; Endarterectomy, Carotid; Female; Flavin Mononucleotide; Heme; Humans; Hypoxia-Ischemia, Brain; Inosine Diphosphate; Male; Middle Aged; Neuroprotective Agents; Niacinamide; Reperfusion Injury; Succinates

2011