inosine-diphosphate and Endotoxemia

The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level. The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation, shorter time of staying in critical condition, more favorable course of complications.

Topics: Adult; Antioxidants; Drug Combinations; Endotoxemia; Female; Flavin Mononucleotide; Free Radicals; Humans; Inosine Diphosphate; Male; Middle Aged; Niacinamide; Peritonitis; Postoperative Complications; Postoperative Period; Succinates

Experiments on Wistar rats showed the development of endotoxicosis 12 h after severe compression injury. Endotoxicosis manifested in disorders in bromosulfaleine excretion from the blood, increase of blood urea, uric acid, creatinine, and potassium levels and aminotransferase activities. Injection of succinate-containing antihypoxants (reamberine, cytoflavin, metaprot plus, succinamic acid 2-amino-4-acetylthiasolo[5,4-b]indole) directly after decompression promoted recovery of liver function, prevented the development of hyperfermentemia and renal failure as a result of reduced blood levels of potassium and non-protein nitrogen. The protective effect of the drugs in traumatic toxicosisdecreased in the following order: metaprot plus>cytoflavin>2-amino-4-acetylthiasolo[5,4-b]indole succinaminic acid>reamberine.

Topics: Animals; Antioxidants; Drug Combinations; Endotoxemia; Flavin Mononucleotide; Inosine Diphosphate; Ischemia; Male; Meglumine; Niacinamide; Nitrogen; Potassium; Rats; Rats, Wistar; Succinates