inosine-diphosphate and Dyslipidemias

Comparative tests on nonlinear rats of both sex with model violation of lipid metabolism have been performed in order to study the effects of cytoflavin (1.75 ml/kg or 175 mg/kg with respect to succinic acid) and cardioxipin (52.5 mg/kg) on lipid peroxidation and antioxidant protection indices in the blood. It is established that these preparations cause a decrease in the content of malonic dialdehyde (MDA) in erythrocytes that results in increased antioxidant activity and lipid reserves for peroxidation in the blood.

Topics: Animals; Animals, Outbred Strains; Antioxidants; Catalase; Drug Combinations; Dyslipidemias; Erythrocytes; Female; Flavin Mononucleotide; Inosine Diphosphate; Lipid Peroxidation; Male; Malondialdehyde; Niacinamide; Protective Agents; Pyridones; Rats; Succinates; Superoxide Dismutase

To compare the effects of cytoflavin and cardioxipin on the emotional status of rats with experimental disturbance of lipid metabolism using the uplifted cruciform labyrinth method.. The disturbance of lipid metabolism was induced by the introduction of exogenic cholesterol-in -oil emulsion in dosage 40 mg /kg of body mass during 20 days. Pharmacological treatment was performed in the 11th day. The drugs were injected intraperitoneally during 10 days: cytoflavin in dose 1,75 ml/ kg (175 mg/kg with succinic acid), cardioxipin in dose 52,5 mg/kg.. Cytoflavin and cardioxipin caused the positive changes in the parameters of emotional status of rats in conditions of experimental dyslipidemia.

Topics: Animals; Anxiety; Disease Models, Animal; Drug Combinations; Dyslipidemias; Emotions; Flavin Mononucleotide; Inosine Diphosphate; Male; Niacinamide; Picolines; Rats; Succinates