inosine-diphosphate and Critical-Illness

The obtained materials were received in the process of examination and treatment of 134 patients in the early phase of severe acute poisoning with the development of opiate toxicohypoxic encephalopathy using a corrector of tissue metabolism Cytoflavinum. Positive clinical results were achieved: reduction of length of stay of patients in a comatose state, reduction of incidence of pulmonary complications and mortality. The results of immunological studies have established immunomodulatory effects of cytoflavinum in patients with severe acute poisoning opiates. These biochemical studies have shown that the effects cytoflavinum realized largely due to its ability correct the effects of tissue hypoxia.

Topics: Acute Disease; Adult; Analgesics, Opioid; Critical Illness; Female; Humans; Inosine Diphosphate; Length of Stay; Male; Neurotoxicity Syndromes; Niacinamide; Opioid-Related Disorders; Riboflavin; Vitamin B Complex

In this article there are materials, which were received in the process of treatment of 69 patients with azaleptin (leponeks) acute severe poisonings. The immunologic research has shown that the first phase of acute poisonings in patients with toxicohypoxic encephalopathy is accompanied by severe immune alterations. The alterations of proinflammation and antiinflammation cytokines have been investigated and its increase has not been revealed. It was shown, that the employment of citoflavin in intensive therapy of acute poisonings leads to decrease of the level of immunosupression.

Topics: Blood Cell Count; Clozapine; Critical Illness; Drug Combinations; Female; Flavin Mononucleotide; Humans; Hypoxia, Brain; Immune System; Inosine Diphosphate; Male; Neurotoxicity Syndromes; Niacinamide; Poisoning; Succinates

Examination and treatment of 262 patients with severe acute intoxication by neurotropic poisons and unaffected oxygen delivery system showed that inclusion of cytoflavin in combined neurometabolic therapy of acute cerebral insufficiency significantly reduced severity of metabolic disorders. Specifically, tissue hypoxy, endotoxicosis, lipid peroxidation activity, and immunosuppression decreased while antioxidative protection and clinical picture were improved. Duration of comatose state and artificial lung ventilation was reduced from 64.5 +/- 15.1 to 28.8 +/- 10.2 hours and that of critical condition from 117.2 +/- 17.2 to 63.7 +/- 9.2 hours. Overall lethality dropped from 16 to 9.9%.

Topics: Acute Disease; CD3 Complex; CD4 Antigens; CD8 Antigens; Coma; Critical Illness; Drug Combinations; Flavin Mononucleotide; Humans; Hypoxia, Brain; Inosine Diphosphate; Lymphocytes; Neuroprotective Agents; Neurotoxicity Syndromes; Niacinamide; Poisoning; Receptors, Interleukin-2; Respiration, Artificial; Succinates