inosine-diphosphate and Chemical-and-Drug-Induced-Liver-Injury

Two-week administration of isoniazid, rifampicin (50 mg/kg and pyrazinamide (1,5 g/kg) to white rats brings about liver affection characterized by a higher activity of alanine and aspartate aminotransferases, lipid peroxidation activation and bile production inhibition. With the liver affected by antituberculous drugs, protective action is provided by acetate tocopherol an antioxidant, and piracetam riboxin and pyriditol, antihypoxic agents.

Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatitis, Animal; Inosine Diphosphate; Isoniazid; Male; Piracetam; Pyrazinamide; Rats; Rifampin; Vitamin E

The results of the experiments with use of isoniazid and its metabolites showed that in the liver of rats isoniazid induced albuminous degeneration with stroma inflammation and hepatocyte necrosis, monoacetylhydrazine induced fatty hepatosis, acetylisoniazid induced fatty hepatosis with stroma inflammation and hepatocyte necrosis and isonicotinic acid induced granular degeneration. Piracetam proved to be efficient in fatty hepatosis. Riboxin and dibunol were efficient in hepatitis. The drugs used clinically as liver protectors, i.e. cobamamide, pyridoxal phosphate and methionine had no protective action in liver affections induced by isoniazid whereas catergen, lipamide, dipromonium and methindione even aggravated such affections.

Topics: Animals; Butylated Hydroxytoluene; Chemical and Drug Induced Liver Injury; Female; Inosine Diphosphate; Isoniazid; Liver; Liver Diseases; Piracetam; Rats

Topics: Acetylcholinesterase; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Herbicides; Humans; Inosine Diphosphate; Liver; Liver Cirrhosis; Methods; Organophosphate Poisoning; Organothiophosphates; Rats