inosine-diphosphate and Burns

Complex clinical and laboratory examination of 60 patients with moderate level of burn damage included determination of the content of intermediate products of lipid peroxidation (LPO) (malonic dialdehyde, diene conjugate, SH groups and tocopherol) in blood and peripheral zone of the skin and hypodermic tissue. At the same time, the activity of superoxide distumase (SOD) and catalase was evaluated. This examination was performed on the first and third days after injury, in the period of burn shock. In the course of conventional therapy, burn shock was characterized by LPO intensification and insufficiency of the blood antioxidant system. Cytoflavin included into the conventional therapy produces improvement in metabolic changes due to the activation of blood SOD and catalase and an increase in tocopherol (vitaminE) content in the blood.

Topics: Adult; Antioxidants; Burns; Case-Control Studies; Catalase; Drug Combinations; Female; Flavin Mononucleotide; Heat-Shock Response; Humans; Inosine Diphosphate; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Niacinamide; Succinates; Superoxide Dismutase; Vitamin E

The thermal injury leads to increasing level of intracellular reactive oxygen specimen (ROS) reducing the antioxidant defense system. This pathway has been associated with endothelial and microvascular dysfunction and finally with multiple organ dysfunction (MOD). The purpose of this prospective, randomized clinical study was to determine the oxidant-antioxidant balance and investigate the effects of antioxidant therapy (cytoflavin) in burns patients with toxic and post-hypoxic encephalopathy. The study included 60 patients with thermal trauma and encephalopathy. Thirty patients received standard intensive therapy and cytoflavin intravenously in dose 10 ml/day 24 h after trauma during 5 days and 30 patients of the control group received standard intensive therapy for burns. Both groups exhibited a high lipid peroxydation (LPO) (malondialdehyde, conjugate trienes) and low levels of the antioxidant defense system, vitamins A and E on the second day after trauma. On the 14th day of treatment, the level of LPO (p<0,01) and total MOD (p<0,05) index were significantly lower and MMSE scores were higher (p<0,01) compared to the control group. In conclusion, cytoflavin, due to its systemic and metabolic effects, was effective in the treatment of post-hypoxic encephalopathy after the thermal injury.

Topics: Adolescent; Adult; Antioxidants; Burns; Drug Combinations; Drug Therapy, Combination; Female; Flavin Mononucleotide; Humans; Hypoxia, Brain; Inosine Diphosphate; Male; Middle Aged; Niacinamide; Oxidative Stress; Succinates; Treatment Outcome; Young Adult

Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of IIIB degree (20% of body surface) against early introduction of antihypoxants reamberin and cytoflavin. It is established that the introduction of antihypoxants reliably prevents the development of typical pathologic processes and hypoxemia, reduces expressiveness of organ dysfunction and extent of mophological changes in internal organs, and increases 1.5 - 2.5 times the survival rate of heavily damaged animals in the acute period of burn injury.

Topics: Acute Disease; Animals; Burns; Drug Combinations; Drug Evaluation, Preclinical; Female; Flavin Mononucleotide; Hypoxia; Inosine Diphosphate; Male; Meglumine; Niacinamide; Rats; Succinates