inosine-diphosphate and Alcoholism

Quality of life has already been investigated in elderly patients with alcohol dependence. Indicators were deteriorated with long-term experience of alcohol and somatic diseases. Practice of Reamberin, Cytoflavin, Cycloferon has improved quality of life and physical status of elderly patients.

Topics: Aged; Alcoholism; Comorbidity; Cytokines; Drug Combinations; Drug Therapy, Combination; Flavin Mononucleotide; Humans; Inosine Diphosphate; Interferon-alpha; Male; Meglumine; Middle Aged; Niacinamide; Quality of Life; Succinates; Surveys and Questionnaires; Treatment Outcome

Cytoflavin was used in the complex detoxification of 30 alcohol-dependent patients and 30 patients of the comparison group who did not receive this drug. It has been shown that cytoflavin promotes the regression of alcohol withdrawal symptoms, including arterial hypertension, tachycardia, nausea, vomiting, hyperhydrosis, tremor, the severity of head and headache. At the same time, cytoflavin significantly reduces the total score on the CIWA-Ar scale and severity of an autonomic component of pathological alcohol craving to the fifth day of treatment. It has been concluded that cytoflavin is effective and safe for the complex detoxification of alcohol-dependent patients.

Topics: Adult; Alcoholism; Drug Combinations; Ethanol; Female; Flavin Mononucleotide; Follow-Up Studies; Humans; Inactivation, Metabolic; Inosine Diphosphate; Niacinamide; Substance Withdrawal Syndrome; Succinates; Treatment Outcome

Forty-seven hospital patients with alcohol-related mental and behavioral disorders were treated at the stage of abstinence syndrome and post-abstinence disorders. Patients were split into two groups: patients of the control group (n=17) received standard therapy. Patients of the second group (n=30) additionally received antihypoxant/antioxidant - cytoflavin. The results revealed that cytoflavin effectively reduced psychopathological symptoms of alcohol addiction.

Topics: Adult; Alcoholism; Drug Combinations; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; Male; Niacinamide; Succinates; Syndrome; Treatment Outcome

The article considers the actual problem in modern medicine, the study of psychiatric symptoms associated with addictive disorders on the background of alcohol abuse in the elderly. It is shown that neurotic pathology in elderly patients with alcohol dependence is characterized by the presence of six major symptoms, reflecting the excitation processes, overcoming compensation, deficit symptoms, irritation and stabilization of the pathological state. It is proved that Cytoflavin, maintaining a certain level of excitement in the cerebral cortex, provides the optimal voltage of compensatory mechanisms in older people in overcoming their psychiatric symptoms, connected with addictive disorders.

Topics: Aged; Alcoholism; Antioxidants; Behavioral Symptoms; Brain; Drug Combinations; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Niacinamide; Psychiatric Status Rating Scales; Psychological Techniques; Psychopathology; Succinates; Treatment Outcome

The article presents the analysis of the structure and dynamics of psychopathology associated with addictive disorders in elderly patients with alcohol dependence. In terms of syndromic approach the structure of neurotic disease in elderly patients with a verified diagnosis of mental and behavioral disorders associated with alcohol consumption was evaluated. In the overall structure of neurotic pathology in these patients the analysis of symptoms of neurotic diseases, the research of the structure of syndromes and their dynamics were carried out, as well as the patient's attitude to the disease and to its manifestations was determined. A factor model of the pathogenesis of neurotic pathology connected with mental and behavioral disorders due to alcohol use in elderly patients was developed. The high clinical effectiveness of the drug "Cytoflavin" used in the reduction of psychiatric symptoms in patients aged from 62 to 74 years with a diagnosis of mental and behavioral disorders associated with alcohol consumption has been shown.

Topics: Aged; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Attitude to Health; Behavior, Addictive; Behavioral Symptoms; Drug Combinations; Flavin Mononucleotide; Humans; Inosine Diphosphate; Male; Middle Aged; Models, Psychological; Neuroprotective Agents; Neurotic Disorders; Niacinamide; Psychopathology; Succinates; Treatment Outcome

The article is devoted to the actual in modern medicine problem as the study of the prevalence of alcohol dependence and its psyhofarmacological correction in the elderly. It is shown that elderly and old age as a result of reduction of the reserve capacity of the organism for clinical pathology becomes addictive specific psychopathological features that affect the course of disease and maintenance of preventive treatment. On the basis of empirical evidence the authors prove that at the border severity of alcohol withdrawal syndrome the drug "Cytoflavin" has a fairly pronounced psyhofarmacological activity for older people with alcohol dependence.

Topics: Age Factors; Aged; Alcohol-Induced Disorders, Nervous System; Alcoholism; Behavioral Symptoms; Drug Combinations; Drug Monitoring; Flavin Mononucleotide; Humans; Inosine Diphosphate; Male; Middle Aged; Neuroprotective Agents; Niacinamide; Prevalence; Russia; Succinates; Treatment Outcome