indoxyl-glucuronide has been researched along with Kidney-Failure--Chronic* in 2 studies
2 other study(ies) available for indoxyl-glucuronide and Kidney-Failure--Chronic
| Article | Year |
|---|---|
Indoxyl-beta-D-glucuronide and 3-indoxyl sulfate in plasma of hemodialysis patients.
The content of indoxyl-beta-D-glucuronide, which has been found in patients' plasma as a new indicator of renal failure, logarithmically correlated with that of 3-indoxyl sulfate (indican) in the plasma of hemodialysis patients, showing another weak correlation with beta(2)-microglobulin content. The content ratio of indoxyl-beta-D-glucuronide to 3-indoxyl sulfate (IG/IS) gradually increased depending on the duration of hemodialysis treatment. Indoxyl-beta-D-glucuronide could be easily dialyzed in the hemodialysis treatment, in contrast to hardly dialyzable 3-indoxyl sulfate which bound to plasma proteins. Therefore, glucuronide conjugation in indole excretion is favorable for hemodialysis patients in that it eliminates indoxyl compounds in blood by hemodialysis. Topics: beta 2-Microglobulin; Chromatography, High Pressure Liquid; Female; Fluorometry; Glucuronates; Humans; Indican; Indoles; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 1996 |
Indoxyl-beta-D-glucuronide, the primary emitter of low-level chemiluminescence in plasma of hemodialysis patients.
Characteristic light emission induced by the oxidation of hydroxyl radicals has been found in plasma of hemodialysis patients (Agatsuma et al., Clin Chem 1992;38:48-55). We purified a primary emitter, a chemiluminescent component peaking at 430 nm, by anion-exchange chromatography and reversed-phase HPLC. By using proton nuclear magnetic resonance and authentic indoxyl compounds, we determined the primary emitter to be indoxyl-beta-D-glucuronide. Absorption and fluorescence spectra of the purified sample coincided well with those of authentic indoxyl-beta-D-glucuronide, as did the peak in the chemiluminescence emission spectrum. Retention time of the purified sample on reversed-phase HPLC, measured by fluorescence, was also in accordance with that of indoxyl-beta-D-glucuronide. To our knowledge, this is the first identification of a primary emitter of low-level chemiluminescence from a biological source. Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Glucuronates; Humans; Hydroxyl Radical; Indoles; Kidney Failure, Chronic; Kinetics; Luminescent Measurements; Magnetic Resonance Spectroscopy; Renal Dialysis; Spectrometry, Fluorescence; Spectrophotometry; Superoxides | 1994 |