indoximod has been researched along with Parkinson-Disease--Secondary* in 1 studies
1 other study(ies) available for indoximod and Parkinson-Disease--Secondary
| Article | Year |
|---|---|
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Human indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan 2,3-dioxygenase (hTDO) have been closely linked to the pathogenesis of Parkinson's disease (PD); nevertheless, development of dual hIDO1 and hTDO inhibitors to evaluate their potential efficacy against PD is still lacking. Here, we report biochemical, biophysical, and computational analyses revealing that 1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Line, Tumor; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Indazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Parkinson Disease, Secondary; Protein Binding; Structure-Activity Relationship; Tryptophan Oxygenase | 2021 |