indoxam and Nerve-Degeneration

Phospholipase A2 (PLA2) is proposed to play a role in the repair of the ruptured membrane after axotomy. In neonatal rats, we examined the effect of Group IIA secretory PLA2 (sPLA2-IIA) on axotomy-induced cell death of motoneurons. sPLA2-IIA significantly induced death of axotomized motoneurons. Indoxam, a specific inhibitor for sPLA2-IIA, protected motoneurons from the sPLA2-IIA-induced deterioration. The present study indicated that sPLA2-IIA possessed neurotoxic effect rather than neuroprotective effect against facial nerve.

Topics: Animals; Animals, Newborn; Axotomy; Carbamates; Cell Death; Enzyme Inhibitors; Facial Nerve; Indolizines; Motor Neurons; Nerve Degeneration; Neuroprotective Agents; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley