indoprofen has been researched along with Rheumatoid Arthritis in 24 studies
Indoprofen: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)
indoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study was aimed at comparing effectiveness, safety and possible steroid sparing effects of indoprofen (800 mg/day) and indomethacin (100 mg/day), in patients with classical or definite rheumatoid arthritis, in active phase, receiving basic steroid treatment at a fixed, not reducible dosage." | 9.05 | Double-blind multicentre, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis patients under basic steroid treatment. ( del Campo, JB, 1981) |
| "Forty-one patients suffering from classical or definite rheumatoid arthritis were randomly allocated to either indoprofen (800 mg/day) or indomethacin (100 mg/day) treatment in a double-blind, comparative long-term study (6 months)." | 9.05 | Long-term, double-blind, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis. ( Bröll, H, 1981) |
| "The results of a multicentre, double-blind trial are reported, where the effectiveness and safety of indoprofen (IP) were compared with indomethacin (IM) and placebo (PL), in patients with rheumatoid arthritis." | 9.05 | Short-term study of indoprofen in comparison with placebo and indomethacin in rheumatoid arthritis. ( Delbarre, F, 1981) |
| "Thirty-six patients suffering from rheumatoid arthritis took part in a double-blind controlled cross-over trial, in which they received either indoprofen 800 mg daily, naproxen 500 mg daily, or a matching placebo." | 9.05 | Indoprofen compared with naproxen and placebo in rheumatoid arthritis. ( Berry, H; Clarke, AK; Davies, J; Dixon, AS; Fernandes, L; Hamilton, EB, 1981) |
| "Thirty patients with classical or definite rheumatoid arthritis were given indoprofen 800 mg/day, ibuprofen 1200 mg/day or placebo in a double-blind cross-over trial, for three consecutive 10-day periods." | 9.05 | Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients. ( Rivelis, L; Scali, JJ, 1981) |
| "Twenty in-patients with rheumatoid arthritis took part in a double-blind, crossover clinical trial to compare the effectiveness and tolerance of 400 mg indoprofen with 1000 mg aspirin each given 3-times a day for 1 week, with an interval of 2 days during which patients received an indistinguishable placebo." | 9.05 | A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis. ( Bruni, G; Loizzi, P; Muratore, M; Sacchetti, G, 1980) |
| "Twenty-four patients suffering from rheumatoid arthritis and requiring articular punctures were treated with 200 mg of indoprofen thrice daily for four days." | 7.67 | Transsynovial kinetics of indoprofen in patients with rheumatoid arthritis and cyclooxygenase-inhibition in vitro. ( Kurowski, M; Schiemann, A; Siebler, D, 1988) |
| "Six patients (4 men, 2 women) with moderate/large knee effusions due to rheumatoid arthritis (RA) were studied after receiving indoprofen, 25 mg intra-articularly and then 200 mg orally 1 week later." | 7.66 | Intra-articular drug therapy in rheumatoid arthritis. A study with indoprofen. ( Christophidis, N; Huskisson, EC, 1982) |
| "Indoprofen was given intravenously (bolus followed by infusion) and orally to 7 patients suffering from active rheumatoid arthritis with knee joint effusion." | 7.66 | Plasma and synovial fluid pharmacokinetics and prostaglandin inhibitory effect of indoprofen in patients with rheumatoid arthritis. ( Caruso, I; Moro, E; Patrono, C; Sacchetti, G; Tamassia, V; Tosolini, GP, 1980) |
| " Indoprofen was administered for 1 week at a daily dosage of 1000 mg according to a treatment schedule used with success in acute gouty arthritis: a 400 mg i." | 5.05 | Indoprofen in rheumatic patients with acute episodes: a multicentre trial. ( Accardo, S; Ambanelli, U; Bassi, G; Bedendo, A; Bianchi, V; Carcassi, U; Caruso, I; Cervi, G; Chérié-Lignière, G; Ciompi, M; Colombo, B; Fumagalli, M; Giordano, N; Goretti, P; Lavezzari, M; Loizzi, P; Manganelli, P; Mansoldo, G; Marcolongo, R; Pasero, G; Pellegrini, P; Perpignano, G; Pipitone, V; Provvedi, D; Rossi, R; Rubegni, M; Todesco, S, 1982) |
| "The study was aimed at comparing effectiveness, safety and possible steroid sparing effects of indoprofen (800 mg/day) and indomethacin (100 mg/day), in patients with classical or definite rheumatoid arthritis, in active phase, receiving basic steroid treatment at a fixed, not reducible dosage." | 5.05 | Double-blind multicentre, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis patients under basic steroid treatment. ( del Campo, JB, 1981) |
| "Forty-one patients suffering from classical or definite rheumatoid arthritis were randomly allocated to either indoprofen (800 mg/day) or indomethacin (100 mg/day) treatment in a double-blind, comparative long-term study (6 months)." | 5.05 | Long-term, double-blind, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis. ( Bröll, H, 1981) |
| "The results of a multicentre, double-blind trial are reported, where the effectiveness and safety of indoprofen (IP) were compared with indomethacin (IM) and placebo (PL), in patients with rheumatoid arthritis." | 5.05 | Short-term study of indoprofen in comparison with placebo and indomethacin in rheumatoid arthritis. ( Delbarre, F, 1981) |
| "Thirty-six patients suffering from rheumatoid arthritis took part in a double-blind controlled cross-over trial, in which they received either indoprofen 800 mg daily, naproxen 500 mg daily, or a matching placebo." | 5.05 | Indoprofen compared with naproxen and placebo in rheumatoid arthritis. ( Berry, H; Clarke, AK; Davies, J; Dixon, AS; Fernandes, L; Hamilton, EB, 1981) |
| "Indoprofen, a new non-steroidal antirheumatic agent, was tested in a controlled, double-blind, cross-over study versus indomethacin and placebo, in 30 patients with rheumatoid arthritis." | 5.05 | Results of a double-blind study with indomethacin and indoprofen, a new non-steroidal antirheumatic agent. ( Schneider, B; Seigmund, H, 1981) |
| "Thirty patients with classical or definite rheumatoid arthritis were given indoprofen 800 mg/day, ibuprofen 1200 mg/day or placebo in a double-blind cross-over trial, for three consecutive 10-day periods." | 5.05 | Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients. ( Rivelis, L; Scali, JJ, 1981) |
| "Twenty in-patients with rheumatoid arthritis took part in a double-blind, crossover clinical trial to compare the effectiveness and tolerance of 400 mg indoprofen with 1000 mg aspirin each given 3-times a day for 1 week, with an interval of 2 days during which patients received an indistinguishable placebo." | 5.05 | A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis. ( Bruni, G; Loizzi, P; Muratore, M; Sacchetti, G, 1980) |
| "Twenty-four patients suffering from rheumatoid arthritis and requiring articular punctures were treated with 200 mg of indoprofen thrice daily for four days." | 3.67 | Transsynovial kinetics of indoprofen in patients with rheumatoid arthritis and cyclooxygenase-inhibition in vitro. ( Kurowski, M; Schiemann, A; Siebler, D, 1988) |
| "Six patients (4 men, 2 women) with moderate/large knee effusions due to rheumatoid arthritis (RA) were studied after receiving indoprofen, 25 mg intra-articularly and then 200 mg orally 1 week later." | 3.66 | Intra-articular drug therapy in rheumatoid arthritis. A study with indoprofen. ( Christophidis, N; Huskisson, EC, 1982) |
| "The pharmacokinetics of indoprofen were investigated in several studies in healthy volunteers and in rheumatoid arthritis patients." | 3.66 | Human pharmacokinetics of indoprofen. ( Tamassia, V, 1981) |
| "Indoprofen was given intravenously (bolus followed by infusion) and orally to 7 patients suffering from active rheumatoid arthritis with knee joint effusion." | 3.66 | Plasma and synovial fluid pharmacokinetics and prostaglandin inhibitory effect of indoprofen in patients with rheumatoid arthritis. ( Caruso, I; Moro, E; Patrono, C; Sacchetti, G; Tamassia, V; Tosolini, GP, 1980) |
| " Pharmacokinetics are no substitute for clinical experiment in planning the dosage regime of a non-steroidal anti-inflammatory drug." | 2.65 | How frequently should anti-inflammatory drugs be given? A study with indoprofen. ( Christophidis, N; Huskisson, EC; Scott, J, 1981) |
| " Long term administration confirmed the safety of indoprofen and the overall incidence of side effects was similar to that associated with ibuprofen therapy." | 2.65 | Three trials of indoprofen. ( Huskisson, EC; Scott, J; Woolf, DL, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ambanelli, U | 2 |
| Bassi, G | 1 |
| Bianchi, V | 1 |
| Carcassi, U | 1 |
| Caruso, I | 2 |
| Colombo, B | 1 |
| Goretti, P | 1 |
| Mansoldo, G | 1 |
| Marcolongo, R | 1 |
| Pasero, G | 2 |
| Pellegrini, P | 1 |
| Pipitone, V | 1 |
| Rubegni, M | 1 |
| Todesco, S | 1 |
| Accardo, S | 1 |
| Bedendo, A | 1 |
| Cervi, G | 1 |
| Chérié-Lignière, G | 1 |
| Ciompi, M | 1 |
| Fumagalli, M | 1 |
| Giordano, N | 1 |
| Lavezzari, M | 1 |
| Loizzi, P | 2 |
| Manganelli, P | 1 |
| Perpignano, G | 1 |
| Provvedi, D | 1 |
| Rossi, R | 1 |
| Shichikawa, K | 1 |
| Ogawa, N | 1 |
| Pavelka, K | 1 |
| Vojtísek, O | 1 |
| Malecek, J | 1 |
| Brémová, A | 1 |
| Bombardieri, S | 1 |
| Cattani, P | 1 |
| Ciabattoni, G | 1 |
| Di Munno, O | 1 |
| Patrono, C | 2 |
| Pinca, E | 1 |
| Pugliese, F | 1 |
| Huskisson, EC | 4 |
| Scott, J | 3 |
| Christophidis, N | 2 |
| del Campo, JB | 1 |
| Bröll, H | 1 |
| Kolarz, G | 1 |
| Delbarre, F | 2 |
| Berry, H | 1 |
| Fernandes, L | 1 |
| Clarke, AK | 1 |
| Hamilton, EB | 1 |
| Davies, J | 1 |
| Dixon, AS | 1 |
| Nissilä, M | 1 |
| Jalava, S | 1 |
| Groppi, W | 1 |
| Seigmund, H | 1 |
| Schneider, B | 1 |
| Scali, JJ | 1 |
| Rivelis, L | 1 |
| Woolf, DL | 1 |
| Tamassia, V | 2 |
| Cagianelli, MA | 1 |
| Mioni, V | 1 |
| Bergamini, N | 1 |
| Ferraccioli, GF | 1 |
| Muratore, M | 1 |
| Bruni, G | 1 |
| Sacchetti, G | 2 |
| Moro, E | 1 |
| Tosolini, GP | 1 |
| Mery, C | 1 |
| Kurowski, M | 1 |
| Schiemann, A | 1 |
| Siebler, D | 1 |
15 trials available for indoprofen and Rheumatoid Arthritis
| Article | Year |
|---|---|
Indoprofen in rheumatic patients with acute episodes: a multicentre trial.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Back Pain; Clinical Trials as Topic; Fema | 1982 |
[Effect of indoprofen in patients with rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; I | 1984 |
[Indoprofen in the treatment of progressive polyarthritis].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indoprofen; Male; Middle Aged; Phen | 1982 |
How frequently should anti-inflammatory drugs be given? A study with indoprofen.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Humans; Indoprofen; Phenylprop | 1981 |
Double-blind multicentre, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis patients under basic steroid treatment.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1981 |
Long-term, double-blind, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Doub | 1981 |
Double-blind, cross-over, international multicentre investigation of two doses of indoprofen compared with ASA and placebo in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, D | 1981 |
Short-term study of indoprofen in comparison with placebo and indomethacin in rheumatoid arthritis.
Topics: Adult; Aged; Analysis of Variance; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Met | 1981 |
Indoprofen compared with naproxen and placebo in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1981 |
Indoprofen versus indomethacin and placebo. A double-blind three-way cross-over trial in rheumatoid arthritis.
Topics: Adult; Aged; Analysis of Variance; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Met | 1981 |
Results of a double-blind study with indomethacin and indoprofen, a new non-steroidal antirheumatic agent.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1981 |
Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Bli | 1981 |
Three trials of indoprofen.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; C | 1981 |
A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; Female; Humans; Indoprofen; Male; | 1980 |
[Short term study of comparing indoprofen with a placebo and with indomethacin in rheumatic polyarthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indom | 1979 |
9 other studies available for indoprofen and Rheumatoid Arthritis
| Article | Year |
|---|---|
The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; F | 1981 |
Intra-articular drug therapy in rheumatoid arthritis. A study with indoprofen.
Topics: Administration, Oral; Arthritis, Rheumatoid; Female; Humans; Indoprofen; Injections, Intra-Articular | 1982 |
Special symposium on indoprofen.
Topics: Animals; Arthritis, Rheumatoid; Humans; Indoprofen; Phenylpropionates | 1981 |
Human pharmacokinetics of indoprofen.
Topics: Administration, Oral; Arthritis, Rheumatoid; Biological Availability; Biotransformation; Half-Life; | 1981 |
Evaluation of the long-term efficacy and safety of indoprofen in rheumatoid arthritis and osteoarthritis patients.
Topics: Aged; Arthritis, Rheumatoid; Female; Hematologic Tests; Humans; Indoprofen; Kidney Function Tests; L | 1981 |
Evaluation of the activity of anti-inflammatory agents by means of skin tests (M.S.U., SK-SD): comparison with clinical results.
Topics: Anti-Inflammatory Agents; Antigens; Arthritis, Rheumatoid; Drug Evaluation; Humans; Immunity, Cellul | 1981 |
Plasma and synovial fluid pharmacokinetics and prostaglandin inhibitory effect of indoprofen in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Indoprofen; Kinetics; Male; Middle Aged; Phenylp | 1980 |
Analgesic and anti-inflammatory properties of indoprofen.
Topics: Arthritis, Rheumatoid; Aspirin; Humans; Ibuprofen; Indoprofen; Phenylpropionates | 1979 |
Transsynovial kinetics of indoprofen in patients with rheumatoid arthritis and cyclooxygenase-inhibition in vitro.
Topics: Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Indopr | 1988 |