Page last updated: 2024-10-29

indoprofen and Neoplasms

indoprofen has been researched along with Neoplasms in 3 studies

Indoprofen: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)
indoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Indoprofen and morphine were not significantly different as regards pain relief, but both were significantly more effective than placebo."6.65Effect of i.v. indoprofen on cancer pain and serum prolactin and growth hormone levels--a controlled pharmacologic study vs i. m. morphine and placebo. ( Bruni, G; Defraia, E; Massidda, B; Parrinello, L; Pellegrini, A; Pellegrini, P; Rigamonti, G; Sacchetti, G; Usai, A, 1983)
" The double-blind cross-over trial was carried out in 18 patients of both sexes suffering from pain due to malignant tumours who received single doses of 200 mg indoprofen and 250 mg naproxen p."5.04A controlled study of the analgetic effect of two non-steroidal anti-inflammatory drugs in cancer pain. ( Emanueli, A; Mandelli, V; Martino, G; Ventafridda, V, 1978)
"Indoprofen and morphine were not significantly different as regards pain relief, but both were significantly more effective than placebo."2.65Effect of i.v. indoprofen on cancer pain and serum prolactin and growth hormone levels--a controlled pharmacologic study vs i. m. morphine and placebo. ( Bruni, G; Defraia, E; Massidda, B; Parrinello, L; Pellegrini, A; Pellegrini, P; Rigamonti, G; Sacchetti, G; Usai, A, 1983)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Pellegrini, A1
Massidda, B1
Pellegrini, P1
Defraia, E1
Usai, A1
Parrinello, L1
Bruni, G1
Rigamonti, G1
Sacchetti, G1
Martino, G1
Emanueli, A1
Mandelli, V1
Ventafridda, V1

Reviews

1 review available for indoprofen and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015

Trials

2 trials available for indoprofen and Neoplasms

ArticleYear
Effect of i.v. indoprofen on cancer pain and serum prolactin and growth hormone levels--a controlled pharmacologic study vs i. m. morphine and placebo.
    International journal of clinical pharmacology, therapy, and toxicology, 1983, Volume: 21, Issue:9

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Growth Hormone; Humans; Indoprof

1983
A controlled study of the analgetic effect of two non-steroidal anti-inflammatory drugs in cancer pain.
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:9

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indoprofen; Male; Middle

1978