indoprofen has been researched along with Arthritis, Rheumatoid in 24 studies
Indoprofen: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)
indoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study was aimed at comparing effectiveness, safety and possible steroid sparing effects of indoprofen (800 mg/day) and indomethacin (100 mg/day), in patients with classical or definite rheumatoid arthritis, in active phase, receiving basic steroid treatment at a fixed, not reducible dosage." | 9.05 | Double-blind multicentre, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis patients under basic steroid treatment. ( del Campo, JB, 1981) |
| "Forty-one patients suffering from classical or definite rheumatoid arthritis were randomly allocated to either indoprofen (800 mg/day) or indomethacin (100 mg/day) treatment in a double-blind, comparative long-term study (6 months)." | 9.05 | Long-term, double-blind, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis. ( Bröll, H, 1981) |
| "The results of a multicentre, double-blind trial are reported, where the effectiveness and safety of indoprofen (IP) were compared with indomethacin (IM) and placebo (PL), in patients with rheumatoid arthritis." | 9.05 | Short-term study of indoprofen in comparison with placebo and indomethacin in rheumatoid arthritis. ( Delbarre, F, 1981) |
| "Thirty-six patients suffering from rheumatoid arthritis took part in a double-blind controlled cross-over trial, in which they received either indoprofen 800 mg daily, naproxen 500 mg daily, or a matching placebo." | 9.05 | Indoprofen compared with naproxen and placebo in rheumatoid arthritis. ( Berry, H; Clarke, AK; Davies, J; Dixon, AS; Fernandes, L; Hamilton, EB, 1981) |
| "Thirty patients with classical or definite rheumatoid arthritis were given indoprofen 800 mg/day, ibuprofen 1200 mg/day or placebo in a double-blind cross-over trial, for three consecutive 10-day periods." | 9.05 | Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients. ( Rivelis, L; Scali, JJ, 1981) |
| "Twenty in-patients with rheumatoid arthritis took part in a double-blind, crossover clinical trial to compare the effectiveness and tolerance of 400 mg indoprofen with 1000 mg aspirin each given 3-times a day for 1 week, with an interval of 2 days during which patients received an indistinguishable placebo." | 9.05 | A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis. ( Bruni, G; Loizzi, P; Muratore, M; Sacchetti, G, 1980) |
| "Twenty-four patients suffering from rheumatoid arthritis and requiring articular punctures were treated with 200 mg of indoprofen thrice daily for four days." | 7.67 | Transsynovial kinetics of indoprofen in patients with rheumatoid arthritis and cyclooxygenase-inhibition in vitro. ( Kurowski, M; Schiemann, A; Siebler, D, 1988) |
| "Six patients (4 men, 2 women) with moderate/large knee effusions due to rheumatoid arthritis (RA) were studied after receiving indoprofen, 25 mg intra-articularly and then 200 mg orally 1 week later." | 7.66 | Intra-articular drug therapy in rheumatoid arthritis. A study with indoprofen. ( Christophidis, N; Huskisson, EC, 1982) |
| "Indoprofen was given intravenously (bolus followed by infusion) and orally to 7 patients suffering from active rheumatoid arthritis with knee joint effusion." | 7.66 | Plasma and synovial fluid pharmacokinetics and prostaglandin inhibitory effect of indoprofen in patients with rheumatoid arthritis. ( Caruso, I; Moro, E; Patrono, C; Sacchetti, G; Tamassia, V; Tosolini, GP, 1980) |
| " Indoprofen was administered for 1 week at a daily dosage of 1000 mg according to a treatment schedule used with success in acute gouty arthritis: a 400 mg i." | 5.05 | Indoprofen in rheumatic patients with acute episodes: a multicentre trial. ( Accardo, S; Ambanelli, U; Bassi, G; Bedendo, A; Bianchi, V; Carcassi, U; Caruso, I; Cervi, G; Chérié-Lignière, G; Ciompi, M; Colombo, B; Fumagalli, M; Giordano, N; Goretti, P; Lavezzari, M; Loizzi, P; Manganelli, P; Mansoldo, G; Marcolongo, R; Pasero, G; Pellegrini, P; Perpignano, G; Pipitone, V; Provvedi, D; Rossi, R; Rubegni, M; Todesco, S, 1982) |
| "The study was aimed at comparing effectiveness, safety and possible steroid sparing effects of indoprofen (800 mg/day) and indomethacin (100 mg/day), in patients with classical or definite rheumatoid arthritis, in active phase, receiving basic steroid treatment at a fixed, not reducible dosage." | 5.05 | Double-blind multicentre, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis patients under basic steroid treatment. ( del Campo, JB, 1981) |
| "Forty-one patients suffering from classical or definite rheumatoid arthritis were randomly allocated to either indoprofen (800 mg/day) or indomethacin (100 mg/day) treatment in a double-blind, comparative long-term study (6 months)." | 5.05 | Long-term, double-blind, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis. ( Bröll, H, 1981) |
| "The results of a multicentre, double-blind trial are reported, where the effectiveness and safety of indoprofen (IP) were compared with indomethacin (IM) and placebo (PL), in patients with rheumatoid arthritis." | 5.05 | Short-term study of indoprofen in comparison with placebo and indomethacin in rheumatoid arthritis. ( Delbarre, F, 1981) |
| "Thirty-six patients suffering from rheumatoid arthritis took part in a double-blind controlled cross-over trial, in which they received either indoprofen 800 mg daily, naproxen 500 mg daily, or a matching placebo." | 5.05 | Indoprofen compared with naproxen and placebo in rheumatoid arthritis. ( Berry, H; Clarke, AK; Davies, J; Dixon, AS; Fernandes, L; Hamilton, EB, 1981) |
| "Indoprofen, a new non-steroidal antirheumatic agent, was tested in a controlled, double-blind, cross-over study versus indomethacin and placebo, in 30 patients with rheumatoid arthritis." | 5.05 | Results of a double-blind study with indomethacin and indoprofen, a new non-steroidal antirheumatic agent. ( Schneider, B; Seigmund, H, 1981) |
| "Thirty patients with classical or definite rheumatoid arthritis were given indoprofen 800 mg/day, ibuprofen 1200 mg/day or placebo in a double-blind cross-over trial, for three consecutive 10-day periods." | 5.05 | Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients. ( Rivelis, L; Scali, JJ, 1981) |
| "Twenty in-patients with rheumatoid arthritis took part in a double-blind, crossover clinical trial to compare the effectiveness and tolerance of 400 mg indoprofen with 1000 mg aspirin each given 3-times a day for 1 week, with an interval of 2 days during which patients received an indistinguishable placebo." | 5.05 | A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis. ( Bruni, G; Loizzi, P; Muratore, M; Sacchetti, G, 1980) |
| "Twenty-four patients suffering from rheumatoid arthritis and requiring articular punctures were treated with 200 mg of indoprofen thrice daily for four days." | 3.67 | Transsynovial kinetics of indoprofen in patients with rheumatoid arthritis and cyclooxygenase-inhibition in vitro. ( Kurowski, M; Schiemann, A; Siebler, D, 1988) |
| "Six patients (4 men, 2 women) with moderate/large knee effusions due to rheumatoid arthritis (RA) were studied after receiving indoprofen, 25 mg intra-articularly and then 200 mg orally 1 week later." | 3.66 | Intra-articular drug therapy in rheumatoid arthritis. A study with indoprofen. ( Christophidis, N; Huskisson, EC, 1982) |
| "The pharmacokinetics of indoprofen were investigated in several studies in healthy volunteers and in rheumatoid arthritis patients." | 3.66 | Human pharmacokinetics of indoprofen. ( Tamassia, V, 1981) |
| "Indoprofen was given intravenously (bolus followed by infusion) and orally to 7 patients suffering from active rheumatoid arthritis with knee joint effusion." | 3.66 | Plasma and synovial fluid pharmacokinetics and prostaglandin inhibitory effect of indoprofen in patients with rheumatoid arthritis. ( Caruso, I; Moro, E; Patrono, C; Sacchetti, G; Tamassia, V; Tosolini, GP, 1980) |
| " Pharmacokinetics are no substitute for clinical experiment in planning the dosage regime of a non-steroidal anti-inflammatory drug." | 2.65 | How frequently should anti-inflammatory drugs be given? A study with indoprofen. ( Christophidis, N; Huskisson, EC; Scott, J, 1981) |
| " Long term administration confirmed the safety of indoprofen and the overall incidence of side effects was similar to that associated with ibuprofen therapy." | 2.65 | Three trials of indoprofen. ( Huskisson, EC; Scott, J; Woolf, DL, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ambanelli, U | 2 |
| Bassi, G | 1 |
| Bianchi, V | 1 |
| Carcassi, U | 1 |
| Caruso, I | 2 |
| Colombo, B | 1 |
| Goretti, P | 1 |
| Mansoldo, G | 1 |
| Marcolongo, R | 1 |
| Pasero, G | 2 |
| Pellegrini, P | 1 |
| Pipitone, V | 1 |
| Rubegni, M | 1 |
| Todesco, S | 1 |
| Accardo, S | 1 |
| Bedendo, A | 1 |
| Cervi, G | 1 |
| Chérié-Lignière, G | 1 |
| Ciompi, M | 1 |
| Fumagalli, M | 1 |
| Giordano, N | 1 |
| Lavezzari, M | 1 |
| Loizzi, P | 2 |
| Manganelli, P | 1 |
| Perpignano, G | 1 |
| Provvedi, D | 1 |
| Rossi, R | 1 |
| Shichikawa, K | 1 |
| Ogawa, N | 1 |
| Pavelka, K | 1 |
| Vojtísek, O | 1 |
| Malecek, J | 1 |
| Brémová, A | 1 |
| Bombardieri, S | 1 |
| Cattani, P | 1 |
| Ciabattoni, G | 1 |
| Di Munno, O | 1 |
| Patrono, C | 2 |
| Pinca, E | 1 |
| Pugliese, F | 1 |
| Huskisson, EC | 4 |
| Scott, J | 3 |
| Christophidis, N | 2 |
| del Campo, JB | 1 |
| Bröll, H | 1 |
| Kolarz, G | 1 |
| Delbarre, F | 2 |
| Berry, H | 1 |
| Fernandes, L | 1 |
| Clarke, AK | 1 |
| Hamilton, EB | 1 |
| Davies, J | 1 |
| Dixon, AS | 1 |
| Nissilä, M | 1 |
| Jalava, S | 1 |
| Groppi, W | 1 |
| Seigmund, H | 1 |
| Schneider, B | 1 |
| Scali, JJ | 1 |
| Rivelis, L | 1 |
| Woolf, DL | 1 |
| Tamassia, V | 2 |
| Cagianelli, MA | 1 |
| Mioni, V | 1 |
| Bergamini, N | 1 |
| Ferraccioli, GF | 1 |
| Muratore, M | 1 |
| Bruni, G | 1 |
| Sacchetti, G | 2 |
| Moro, E | 1 |
| Tosolini, GP | 1 |
| Mery, C | 1 |
| Kurowski, M | 1 |
| Schiemann, A | 1 |
| Siebler, D | 1 |
15 trials available for indoprofen and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Indoprofen in rheumatic patients with acute episodes: a multicentre trial.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Back Pain; Clinical Trials as Topic; Fema | 1982 |
[Effect of indoprofen in patients with rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; I | 1984 |
[Indoprofen in the treatment of progressive polyarthritis].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indoprofen; Male; Middle Aged; Phen | 1982 |
How frequently should anti-inflammatory drugs be given? A study with indoprofen.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Humans; Indoprofen; Phenylprop | 1981 |
Double-blind multicentre, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis patients under basic steroid treatment.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1981 |
Long-term, double-blind, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Doub | 1981 |
Double-blind, cross-over, international multicentre investigation of two doses of indoprofen compared with ASA and placebo in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, D | 1981 |
Short-term study of indoprofen in comparison with placebo and indomethacin in rheumatoid arthritis.
Topics: Adult; Aged; Analysis of Variance; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Met | 1981 |
Indoprofen compared with naproxen and placebo in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1981 |
Indoprofen versus indomethacin and placebo. A double-blind three-way cross-over trial in rheumatoid arthritis.
Topics: Adult; Aged; Analysis of Variance; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Met | 1981 |
Results of a double-blind study with indomethacin and indoprofen, a new non-steroidal antirheumatic agent.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1981 |
Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Bli | 1981 |
Three trials of indoprofen.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; C | 1981 |
A double-blind, crossover comparison between indoprofen and aspirin in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; Female; Humans; Indoprofen; Male; | 1980 |
[Short term study of comparing indoprofen with a placebo and with indomethacin in rheumatic polyarthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indom | 1979 |
9 other studies available for indoprofen and Arthritis, Rheumatoid
| Article | Year |
|---|---|
The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; F | 1981 |
Intra-articular drug therapy in rheumatoid arthritis. A study with indoprofen.
Topics: Administration, Oral; Arthritis, Rheumatoid; Female; Humans; Indoprofen; Injections, Intra-Articular | 1982 |
Special symposium on indoprofen.
Topics: Animals; Arthritis, Rheumatoid; Humans; Indoprofen; Phenylpropionates | 1981 |
Human pharmacokinetics of indoprofen.
Topics: Administration, Oral; Arthritis, Rheumatoid; Biological Availability; Biotransformation; Half-Life; | 1981 |
Evaluation of the long-term efficacy and safety of indoprofen in rheumatoid arthritis and osteoarthritis patients.
Topics: Aged; Arthritis, Rheumatoid; Female; Hematologic Tests; Humans; Indoprofen; Kidney Function Tests; L | 1981 |
Evaluation of the activity of anti-inflammatory agents by means of skin tests (M.S.U., SK-SD): comparison with clinical results.
Topics: Anti-Inflammatory Agents; Antigens; Arthritis, Rheumatoid; Drug Evaluation; Humans; Immunity, Cellul | 1981 |
Plasma and synovial fluid pharmacokinetics and prostaglandin inhibitory effect of indoprofen in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Indoprofen; Kinetics; Male; Middle Aged; Phenylp | 1980 |
Analgesic and anti-inflammatory properties of indoprofen.
Topics: Arthritis, Rheumatoid; Aspirin; Humans; Ibuprofen; Indoprofen; Phenylpropionates | 1979 |
Transsynovial kinetics of indoprofen in patients with rheumatoid arthritis and cyclooxygenase-inhibition in vitro.
Topics: Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Indopr | 1988 |