indoprofen has been researched along with Arthritis, Degenerative in 22 studies
Indoprofen: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)
indoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A comparison was made between indoprofen (800 mg/day), naproxen (500 mg/day) and placebo in 30 patients with well defined osteoarthritis of the hip." | 9.05 | Indoprofen. Short-term double-blind cross-over study in patients with osteoarthritis of the hip. ( Carion, J; Debelle, M; Van der Mijnsbrugge, J, 1981) |
| "This paper contains a detailed account of the results obtained in 1629 patients with osteoarthritis treated with indoprofen, a recently introduced non-steroidal anti-inflammatory drug." | 9.05 | Indoprofen in the treatment of osteoarthritis. Results of a phase IV multiclinic study in 1629 patients. ( Emanueli, A; Sacchetti, G, 1981) |
| "The effectiveness, safety and acceptability of indoprofen (IP) and acetylsalicylic acid (ASA) were assessed in patients with osteoarthritis, in a double-blind comparative trial." | 9.05 | Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis. ( Katona, G, 1981) |
| "Patients suffering from osteoarthritis of the large joints or spine randomly allocated to either of two dose levels of indoprofen (IP, 300 or 600 mg/day) or indomethacin (IM, 75 mg/day)." | 9.05 | Double-blind multicentre, between patients comparison of two different doses of indoprofen and one of indomethacin in osteoarthritis. ( Bahous, I, 1981) |
| "Each treatment (indoprofen 300 or 600 mg/day, ASA 1500 + diazepam 6 mg/day, and matching placebo) was administered for 7 days." | 6.65 | Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis. ( Bergamini, N; Groppi, W; Mandelli, V; Valtonen, E, 1981) |
| " Indoprofen was administered for 1 week at a daily dosage of 1000 mg according to a treatment schedule used with success in acute gouty arthritis: a 400 mg i." | 5.05 | Indoprofen in rheumatic patients with acute episodes: a multicentre trial. ( Accardo, S; Ambanelli, U; Bassi, G; Bedendo, A; Bianchi, V; Carcassi, U; Caruso, I; Cervi, G; Chérié-Lignière, G; Ciompi, M; Colombo, B; Fumagalli, M; Giordano, N; Goretti, P; Lavezzari, M; Loizzi, P; Manganelli, P; Mansoldo, G; Marcolongo, R; Pasero, G; Pellegrini, P; Perpignano, G; Pipitone, V; Provvedi, D; Rossi, R; Rubegni, M; Todesco, S, 1982) |
| "A comparison was made between indoprofen (800 mg/day), naproxen (500 mg/day) and placebo in 30 patients with well defined osteoarthritis of the hip." | 5.05 | Indoprofen. Short-term double-blind cross-over study in patients with osteoarthritis of the hip. ( Carion, J; Debelle, M; Van der Mijnsbrugge, J, 1981) |
| "This paper contains a detailed account of the results obtained in 1629 patients with osteoarthritis treated with indoprofen, a recently introduced non-steroidal anti-inflammatory drug." | 5.05 | Indoprofen in the treatment of osteoarthritis. Results of a phase IV multiclinic study in 1629 patients. ( Emanueli, A; Sacchetti, G, 1981) |
| "The effectiveness, safety and acceptability of indoprofen (IP) and acetylsalicylic acid (ASA) were assessed in patients with osteoarthritis, in a double-blind comparative trial." | 5.05 | Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis. ( Katona, G, 1981) |
| "Patients suffering from osteoarthritis of the large joints or spine randomly allocated to either of two dose levels of indoprofen (IP, 300 or 600 mg/day) or indomethacin (IM, 75 mg/day)." | 5.05 | Double-blind multicentre, between patients comparison of two different doses of indoprofen and one of indomethacin in osteoarthritis. ( Bahous, I, 1981) |
| " All of them had maturity-onset diabetes mellitus and were on sulfonylurea drugs (tolbutamide or glipizide)." | 5.05 | A study of the possible interaction of indoprofen with hypoglycemic sulfonylureas in diabetic patients. ( Bommartini, F; Emanueli, A; Freddo, J; Pedrazzi, F, 1981) |
| " administration of indoprofen on template bleeding time and other haemostatic parameters was investigated in ten elderly subjects with osteoarthritis." | 3.66 | Effects of intravenous indoprofen on bleeding time and other haemostatic parameters. ( Bandinelli, C; Bruni, G; De Mauro, G; Provvedi, D; Rubegni, M; Sacchetti, G, 1982) |
| "Safety data on indoprofen are presented, deriving from three sources: the first was a phase 4 multicentre clinical study based on 4042 patients suffering from osteoarthritis and treated with 400-800 mg daily by mouth for about 4 weeks; the second was a survey based on a heterogeneous series of 2722 subjects belonging to phase 1, 2 and 3 investigations, and treated with 200 to 1200 mg daily by the oral and/or parenteral route for from 1 to more than 180 days; the third was a safety laboratory study conducted in 472 patients, most of whom had participated in the first study, while the remainder were included in the second." | 3.66 | Adverse reactions to indoprofen: a survey based on a total of 6764 patients. ( Battaglia, A; Bruni, G; Emanueli, A; Lavezzari, M; Perbellini, A, 1982) |
| "Diclofenac was preferred to naproxen, aspirin and indomethacin, while piroxicam and placebo were preferred only to aspirin." | 2.66 | Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. ( Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D, 1985) |
| "Each treatment (indoprofen 300 or 600 mg/day, ASA 1500 + diazepam 6 mg/day, and matching placebo) was administered for 7 days." | 2.65 | Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis. ( Bergamini, N; Groppi, W; Mandelli, V; Valtonen, E, 1981) |
| "Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non-steroidal anti-inflammatory drug with a short half-life (t1/2), revealed drug accumulation in eight elderly subjects." | 1.27 | Pharmacokinetic profile of indoprofen in elderly subjects. ( Andersen, RB; Egsmose, C; Knudsen, O; Lund, B, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ambanelli, U | 2 |
| Bassi, G | 1 |
| Bianchi, V | 1 |
| Carcassi, U | 1 |
| Caruso, I | 1 |
| Colombo, B | 1 |
| Goretti, P | 1 |
| Mansoldo, G | 1 |
| Marcolongo, R | 3 |
| Pasero, G | 1 |
| Pellegrini, P | 1 |
| Pipitone, V | 1 |
| Rubegni, M | 4 |
| Todesco, S | 1 |
| Accardo, S | 1 |
| Bedendo, A | 1 |
| Cervi, G | 1 |
| Chérié-Lignière, G | 1 |
| Ciompi, M | 1 |
| Fumagalli, M | 1 |
| Giordano, N | 3 |
| Lavezzari, M | 3 |
| Loizzi, P | 1 |
| Manganelli, P | 1 |
| Perpignano, G | 1 |
| Provvedi, D | 3 |
| Rossi, R | 1 |
| Mattara, L | 2 |
| Leardini, G | 1 |
| Gruni, G | 1 |
| Mandelli, V | 3 |
| Egsmose, C | 2 |
| Lund, B | 2 |
| Bach Andersen, R | 1 |
| Emanueli, A | 5 |
| Sacchetti, G | 5 |
| Debelle, M | 1 |
| Carion, J | 1 |
| Van der Mijnsbrugge, J | 1 |
| Katona, G | 1 |
| Bahous, I | 1 |
| Pedrazzi, F | 1 |
| Bommartini, F | 1 |
| Freddo, J | 1 |
| Bruni, G | 3 |
| De Mauro, G | 2 |
| Valtonen, E | 1 |
| Bergamini, N | 2 |
| Groppi, W | 1 |
| Bandinelli, C | 1 |
| Perbellini, A | 1 |
| Battaglia, A | 1 |
| Cagianelli, MA | 1 |
| Mioni, V | 1 |
| Ferraccioli, GF | 1 |
| Tedoldi, A | 1 |
| Berton, A | 1 |
| Ferrati, G | 2 |
| Bellini, PG | 1 |
| Giro, C | 1 |
| Lo Presti, R | 1 |
| Mascellani, G | 1 |
| Knudsen, O | 1 |
| Andersen, RB | 1 |
| Bassi, GP | 1 |
| Giannini, R | 1 |
| Borghi, C | 1 |
| Francucci, BM | 1 |
| Camarri, E | 1 |
| Mordini, M | 1 |
| Cocco, F | 1 |
| Neri, D | 1 |
| Fornasari, PA | 1 |
13 trials available for indoprofen and Arthritis, Degenerative
| Article | Year |
|---|---|
Indoprofen in rheumatic patients with acute episodes: a multicentre trial.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Back Pain; Clinical Trials as Topic; Fema | 1982 |
A short-term, double-blind comparison between indoprofen and diclofenac in osteoarthritis.
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Humans; Indoprofen; | 1983 |
Hip joint distension in osteoarthrosis. A triple-blind controlled study comparing the effect of intra-articular indoprofen with placebo.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Hip Joint; Humans; Indoprofen; Injections, Intra-Arti | 1984 |
Indoprofen. Short-term double-blind cross-over study in patients with osteoarthritis of the hip.
Topics: Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic | 1981 |
Indoprofen in the treatment of osteoarthritis. Results of a phase IV multiclinic study in 1629 patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Female; Humans; Indoprofen; Italy | 1981 |
Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Double-Blin | 1981 |
Double-blind multicentre, between patients comparison of two different doses of indoprofen and one of indomethacin in osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Dose-Response Relati | 1981 |
A study of the possible interaction of indoprofen with hypoglycemic sulfonylureas in diabetic patients.
Topics: Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Double-Bli | 1981 |
A double-blind evaluation of oral indoprofen versus ASA in osteoarthritic patients: influence on haemostatic parameters and clinical effects.
Topics: Adult; Aged; Aspirin; Bleeding Time; Clinical Trials as Topic; Double-Blind Method; Female; Heartbur | 1981 |
Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis.
Topics: Aged; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Fema | 1981 |
[Therapeutic research on osteoarthrosis in the aged: controlled trial of indoprofen and ibuprofen].
Topics: Age Factors; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Ibuprofen; Indoprofen; | 1978 |
[Double-blind comparative study of indoprofen and ibuprofen in patients with osteoarthrosis].
Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Ibupro | 1979 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration | 1985 |
9 other studies available for indoprofen and Arthritis, Degenerative
| Article | Year |
|---|---|
An algorithm for the classification of untoward events in large scale clinical trials.
Topics: Clinical Trials as Topic; Humans; Indoprofen; Mathematics; Osteoarthritis; Phenylpropionates | 1980 |
Effects of intravenous indoprofen on bleeding time and other haemostatic parameters.
Topics: Aged; Bleeding Time; Blood Coagulation; Female; Humans; Indoprofen; Kinetics; Male; Middle Aged; Ost | 1982 |
Adverse reactions to indoprofen: a survey based on a total of 6764 patients.
Topics: Adult; Age Factors; Aged; Body Height; Body Weight; Cardiovascular Diseases; Female; Gastrointestina | 1982 |
Evaluation of the long-term efficacy and safety of indoprofen in rheumatoid arthritis and osteoarthritis patients.
Topics: Aged; Arthritis, Rheumatoid; Female; Hematologic Tests; Humans; Indoprofen; Kidney Function Tests; L | 1981 |
Evaluation of the activity of anti-inflammatory agents by means of skin tests (M.S.U., SK-SD): comparison with clinical results.
Topics: Anti-Inflammatory Agents; Antigens; Arthritis, Rheumatoid; Drug Evaluation; Humans; Immunity, Cellul | 1981 |
[Indoprofen in the treatment of osteoarthrosis of the knee: comparison with indomethacin].
Topics: Aged; Drug Evaluation; Female; Humans; Indomethacin; Indoprofen; Knee Joint; Male; Middle Aged; Oste | 1980 |
Indoprofen, a new non-steroidal anti-inflammatory drug, in the treatment of osteoarthrosis: report on a multi-centre study in 1629 patients.
Topics: Adult; Aged; Constipation; Diarrhea; Digestive System; Drug Evaluation; Drug Tolerance; Female; Hear | 1979 |
Pharmacokinetic profile of indoprofen in elderly subjects.
Topics: Aged; Female; Half-Life; Humans; Indoprofen; Kinetics; Male; Middle Aged; Osteoarthritis; Phenylprop | 1986 |
[Efficacy and tolerance of dexindoprofen compared with diclofenac sodium in the treatment of osteoarthrosis patients].
Topics: Adult; Aged; Anti-Inflammatory Agents; Diclofenac; Drug Tolerance; Female; Humans; Indoprofen; Male; | 1985 |