indomethacin-farnesil and Sjogren-s-Syndrome

indomethacin-farnesil has been researched along with Sjogren-s-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for indomethacin-farnesil and Sjogren-s-Syndrome

Article	Year
Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil. Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:5 We report a patient with Sjögren's syndrome and chronic natural killer lymphocytosis, who developed severe neutropenia, autoimmune hemolytic anemia, and immune thrombocytopenia. High-dose prednisolone therapy improved the hemolytic anemia and thrombocytopenia, but not the CD16(+) CD56(-) NK lymphocytosis completely. Interestingly, indomethacin farnesil (a prodrug of indomethacin) was effective for myalgia and also decreased the number of CD16(+) CD56(-) NK cells. NK lymphocytosis is rarely associated with autoimmune disease, but the combination of indomethacin and steroid therapy may have a favorable effect for such patients. Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Glucocorticoids; Humans; Indomethacin; Killer Cells, Natural; Lymphocytosis; Prednisolone; Sialadenitis; Sjogren's Syndrome; Treatment Outcome	2007

Article

Year

Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil.

Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:5

We report a patient with Sjögren's syndrome and chronic natural killer lymphocytosis, who developed severe neutropenia, autoimmune hemolytic anemia, and immune thrombocytopenia. High-dose prednisolone therapy improved the hemolytic anemia and thrombocytopenia, but not the CD16(+) CD56(-) NK lymphocytosis completely. Interestingly, indomethacin farnesil (a prodrug of indomethacin) was effective for myalgia and also decreased the number of CD16(+) CD56(-) NK cells. NK lymphocytosis is rarely associated with autoimmune disease, but the combination of indomethacin and steroid therapy may have a favorable effect for such patients.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Glucocorticoids; Humans; Indomethacin; Killer Cells, Natural; Lymphocytosis; Prednisolone; Sialadenitis; Sjogren's Syndrome; Treatment Outcome

2007