indomethacin has been researched along with Xeroderma Pigmentosum in 6 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Xeroderma Pigmentosum: A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited DMBA-induced inflammation and local immunosuppression." | 3.71 | Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2. ( Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2001) |
| "Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited UV-induced ear swelling, abrogated local immunosuppression, and decreased the amount of PGE2 in the ear skin of XPA-deficient mice." | 1.31 | Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice. ( Eguchi, N; Horio, T; Inui, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2000) |
| "Treatment with etretinate and in a later phase with indomethacin and prednisolone was not effective, except for a limited initial response of the tumour to etretinate." | 1.28 | Xeroderma pigmentosum: squamous cell carcinoma of the tongue. ( Keukens, F; Kleijer, WJ; Oosterhuis, JW; Panders, AK; van Voorst Vader, PC; Vinks, S, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tobia, L | 1 |
| Al-Salem, T | 1 |
| Ali, ZS | 1 |
| Qassab, M | 1 |
| Miller, CS | 1 |
| Jacob, RJ | 1 |
| Hiser, DG | 1 |
| Kuwamoto, K | 2 |
| Miyauchi-Hashimoto, H | 2 |
| Tanaka, K | 2 |
| Eguchi, N | 1 |
| Inui, T | 1 |
| Urade, Y | 2 |
| Horio, T | 2 |
| Keukens, F | 1 |
| van Voorst Vader, PC | 1 |
| Panders, AK | 1 |
| Vinks, S | 1 |
| Oosterhuis, JW | 1 |
| Kleijer, WJ | 1 |
6 other studies available for indomethacin and Xeroderma Pigmentosum
| Article | Year |
|---|---|
[The therapeutic problem of cutaneous photosensitization. Considerations on a case of xeroderma pigmentosum].
Topics: Adolescent; Carcinoma, Basal Cell; Female; Humans; Indomethacin; Photosensitivity Disorders; Skin Ne | 1967 |
Skin cancers in xeroderma pigmentosum: response to indomethacin and steroids.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Indomethacin; | 1980 |
UV-enhanced replication of herpes simplex virus in DNA-repair competent and deficient fibroblasts.
Topics: DNA Repair; DNA Replication; DNA, Viral; Fibroblasts; Herpes Simplex; Humans; Indomethacin; Prostagl | 1993 |
Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytosol; Dinoprost; Dinoprostone; Disease Models, Anima | 2000 |
Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Administration, Cutaneous; Animals; Anti-I | 2001 |
Xeroderma pigmentosum: squamous cell carcinoma of the tongue.
Topics: Carcinoma, Squamous Cell; Child; Etretinate; Humans; Indomethacin; Male; Prednisolone; Tongue Neopla | 1989 |