Page last updated: 2024-10-29

indomethacin and Vomiting

indomethacin has been researched along with Vomiting in 23 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.

Research Excerpts

ExcerptRelevanceReference
" In the present studies, therefore, we used Suncus murinus, a species of insectivore capable of emesis, to investigate if the vanilloid receptor agonist resiniferatoxin is capable of modeling the emesis associated with migraine."7.73Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew). ( Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C, 2005)
" One hour prior to cisplatin, controls (n=29) were dosed with a saline solution while experimental animals received an i."5.31The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets. ( Bouvier, M; Dapzol, J; Girod, V; Grélot, L, 2002)
"There was no statistical difference in the mean reduction in pain score between any of the combinations at any point, although combination therapy was the first to reach a clinically significant reduction in pain score (<13 mm), and diclofenac-paracetamol combinations consistently produced a greater reduction in mean pain score than either nonsteroidal antiinflammatory drugs or paracetamol alone."5.11Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. ( Lam, PK; Man, SY; Rainer, TH; Woo, WW, 2005)
" In the present studies, therefore, we used Suncus murinus, a species of insectivore capable of emesis, to investigate if the vanilloid receptor agonist resiniferatoxin is capable of modeling the emesis associated with migraine."3.73Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew). ( Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C, 2005)
"A prematurely born girl presented with abdominal distension, bilious vomiting and a football sign on a plain abdominal X-ray, due to accumulation of free gas following infarction and perforation of the ileum: a complication of indomethacine."3.73[Diagnostic image (232). A neonate with bilious vomiting]. ( de Vries, A; van Rijn, RR, 2005)
" One hour prior to cisplatin, controls (n=29) were dosed with a saline solution while experimental animals received an i."1.31The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets. ( Bouvier, M; Dapzol, J; Girod, V; Grélot, L, 2002)
"Domperidone pretreatment prevented radiation-induced emesis in all of four dogs tested."1.27Radiation-induced emesis in the dog: effects of lesions and drugs. ( Briggs, DB; Carpenter, DO; Knox, AP; Strominger, NL, 1986)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199012 (52.17)18.7374
1990's2 (8.70)18.2507
2000's9 (39.13)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mariano Da Silva, H1
Alcantara, MC1
Bordini, CA1
Speciali, JG1
Cheng, FH1
Andrews, PL1
Moreaux, B1
Ngan, MP2
Rudd, JA2
Sam, TS2
Wai, MK1
Wan, C1
de Vries, A1
van Rijn, RR1
Woo, WW1
Man, SY1
Lam, PK1
Rainer, TH1
Borrás-Blasco, J1
Enriquez, R1
Sirvent, AE1
Amoros, F1
Navarro-Ruiz, A1
Reyes, A1
Riendeau, D1
Robichaud, A1
Emmerson, BT1
Sims, C1
Johnson, CM1
Bergesio, R1
Delfos, SJ1
Avraamides, EA1
Turner, GA1
Anson, N1
Williamson, R1
Girod, V2
Bouvier, M2
Grélot, L2
Proesmans, W1
Dapzol, J1
Elder, MG1
Kapadia, L1
Tausch, G1
Eberl, R1
Tuschl, P1
Lundström, V1
Gréen, K1
Wiqvist, N1
Sato, T1
Igarashi, N1
Minami, S1
Okabe, T1
Hashimoto, H1
Hasui, M1
Kato, E1
Scheuber, PH1
Denzlinger, C1
Wilker, D1
Beck, G1
Keppler, D1
Hammer, DK1
Carpenter, DO2
Briggs, DB2
Strominger, NL2
Knox, AP1
Lazar, M1
Weiner, MJ1
Leopold, IH1
Bain, LS1
Masheter, HC1
Buchmann, E1
Sänger, L1
Stoeber, E1
Kölle, G1

Trials

7 trials available for indomethacin and Vomiting

ArticleYear
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
    Annals of emergency medicine, 2005, Volume: 46, Issue:4

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans

2005
Rectal indomethacin for analgesia after appendicectomy in children.
    Anaesthesia and intensive care, 1994, Volume: 22, Issue:3

    Topics: Administration, Rectal; Analgesia; Analgesia, Patient-Controlled; Appendectomy; Child; Double-Blind

1994
A comparison of intramuscular ketorolac with indomethacin suppositories in the treatment of pain after oral surgery.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethac

1996
Indomethacin in the treatment of primary dysmenorrhoea.
    British journal of obstetrics and gynaecology, 1979, Volume: 86, Issue:8

    Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Dysmenorrhea; Fem

1979
[Clinical experiences and results of clinical experimental studies with Voltaren in rheumatic diseases].
    Wiener medizinische Wochenschrift (1946), 1976, Mar-05, Volume: 126, Issue:10

    Topics: Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Diclofenac; DNA Repair; Drug Evalu

1976
Flufenamic acid and indomethacin in rheumatoid arthritis.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diarrhea; Digestion; Fema

1966
Mefenamic acid compared with indomethacin and placebo in osteoarthritis.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Diarrhea; Digestion; Duodenal Ulcer; Female; Fol

1966

Other Studies

16 other studies available for indomethacin and Vomiting

ArticleYear
Strictly unilateral headache reminiscent of hemicrania continua resistant to indomethacin but responsive to gabapentin.
    Cephalalgia : an international journal of headache, 2002, Volume: 22, Issue:5

    Topics: Acetates; Adult; Amines; Anti-Inflammatory Agents, Non-Steroidal; Blepharoptosis; Cyclohexanecarboxy

2002
Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).
    European journal of pharmacology, 2005, Jan-31, Volume: 508, Issue:1-3

    Topics: Animals; Antiemetics; Butanols; Capsaicin; Cyclooxygenase Inhibitors; Dihydroergotamine; Diphenhydra

2005
[Diagnostic image (232). A neonate with bilious vomiting].
    Nederlands tijdschrift voor geneeskunde, 2005, Mar-19, Volume: 149, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bile; Female; Humans; Ileum; Indomethacin; Infant, Newborn;

2005
Acute renal failure associated with an accidental overdose of colchicine.
    International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:10

    Topics: Acute Kidney Injury; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty

2005
Action of cyclooxygenase inhibitors and a leukotriene biosynthesis inhibitor on cisplatin-induced acute and delayed emesis in the ferret.
    Journal of pharmacological sciences, 2007, Volume: 103, Issue:2

    Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; D

2007
Regimen of indomethacin therapy in acute gouty arthritis.
    British medical journal, 1967, Apr-29, Volume: 2, Issue:5547

    Topics: Adult; Creatine; Female; Gout; Headache; Humans; Indomethacin; Male; Middle Aged; Nausea; Urea; Uric

1967
Characterization of lipopolysaccharide-induced emesis in conscious piglets: effects of cervical vagotomy, cyclooxygenase inhibitors and a 5-HT(3) receptor antagonist.
    Neuropharmacology, 2000, Volume: 39, Issue:12

    Topics: Animals; Antiemetics; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas

2000
How can one apply rescue indomethacin therapy to a 1-month-old baby with antenatal Bartter syndrome in the case of severe vomiting?
    Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:6

    Topics: Bartter Syndrome; Humans; Indomethacin; Infant, Newborn; Salvage Therapy; Vomiting

2001
The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets.
    Neuropharmacology, 2002, Volume: 42, Issue:3

    Topics: Animals; Antiemetics; Antineoplastic Agents; Cisplatin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxy

2002
Prostaglandins, indomethacin and dysmenorrhea.
    Prostaglandins, 1976, Volume: 11, Issue:5

    Topics: Diarrhea; Dysmenorrhea; Female; Humans; Indomethacin; Menstruation; Nausea; Prostaglandins F; Uterin

1976
Recurrent attacks of vomiting, hypertension and psychotic depression: a syndrome of periodic catecholamine and prostaglandin discharge.
    Acta endocrinologica, 1988, Volume: 117, Issue:2

    Topics: Adolescent; Adrenocorticotropic Hormone; Arginine Vasopressin; Child, Preschool; Clonidine; Dinopros

1988
Staphylococcal enterotoxin B as a nonimmunological mast cell stimulus in primates: the role of endogenous cysteinyl leukotrienes.
    International archives of allergy and applied immunology, 1987, Volume: 82, Issue:3-4

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Animals; Enterotoxins;

1987
Mechanisms of radiation-induced emesis in the dog.
    Pharmacology & therapeutics, 1988, Volume: 39, Issue:1-3

    Topics: Animals; Dogs; Domperidone; Electrophysiology; Female; Indomethacin; Male; Radiation Injuries, Exper

1988
Radiation-induced emesis in the dog: effects of lesions and drugs.
    Radiation research, 1986, Volume: 108, Issue:3

    Topics: Animals; Apomorphine; Cerebral Ventricles; Dogs; Domperidone; Indomethacin; Neurons; Prostaglandins;

1986
Treatment of uveitis with methotrexate.
    American journal of ophthalmology, 1969, Volume: 67, Issue:3

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Alopecia; Anti-Bacterial Agents; Child;

1969
[Long term therapy with indomethacin in juvenile rheumatoid arthritis and in Still's disease].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:11

    Topics: Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Humans; Indomethacin; Nausea; Vomiting

1967