indomethacin has been researched along with Uveitis in 48 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
Excerpt | Relevance | Reference |
---|---|---|
"5% indomethacin (INDOM) eye drops in adult patients suffering from macular edema (ME) related to different etiology uveitis." | 9.19 | Randomized, double-blind, placebo-controlled clinical trial on the efficacy of 0.5% indomethacin eye drops in uveitic macular edema. ( Allegri, P; Autuori, S; Carniglia, R; Compiano, S; Crivelli, MG; Marrazzo, G; Mastromarino, A; Murialdo, U; Peri, S; Zurria, M, 2014) |
" When the eyes were treated with histamine, a complement C5a analogue peptide and hydrogen peroxide, typical signs of uveitis were produced." | 7.70 | Arterially perfused eye model of uveitis. ( Sanderson, SD; Shiels, IA; Taylor, SM, 1999) |
"The causes of fibrinous uveitis after cataract surgery are unclear, but surface modification of polymethylmethacrylate (PMMA) is known to influence post-operative inflammation." | 7.68 | Fibrinous uveitis and intraocular lens implantation. Surface modification of polymethylmethacrylate during extracapsular cataract surgery. ( Rose, GE, 1992) |
"5% indomethacin (INDOM) eye drops in adult patients suffering from macular edema (ME) related to different etiology uveitis." | 5.19 | Randomized, double-blind, placebo-controlled clinical trial on the efficacy of 0.5% indomethacin eye drops in uveitic macular edema. ( Allegri, P; Autuori, S; Carniglia, R; Compiano, S; Crivelli, MG; Marrazzo, G; Mastromarino, A; Murialdo, U; Peri, S; Zurria, M, 2014) |
"Rats were injected with LPS to induce uveitis and divided into three groups: treated with LPS only, LPS + dexamethasone and LPS + indomethacin, respectively." | 3.72 | The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats. ( Bajor, T; Farkas, A; Hrabák, A; Szabó, A; Vámos, R, 2004) |
" When the eyes were treated with histamine, a complement C5a analogue peptide and hydrogen peroxide, typical signs of uveitis were produced." | 3.70 | Arterially perfused eye model of uveitis. ( Sanderson, SD; Shiels, IA; Taylor, SM, 1999) |
" Indomethacin (IM) enhanced TNF production in all the eight TCC that were established from a patient with human T lymphotrophic virus type 1 uveitis or pulmonary sarcoidosis, and suppressed IL-6 production in six of the eight TCC, without affecting their low levels of PGE2 production." | 3.69 | Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production. ( Itoh, K; Nakao, M; Shichijo, S; Tanaka, H; Tsuboi, I, 1995) |
"The causes of fibrinous uveitis after cataract surgery are unclear, but surface modification of polymethylmethacrylate (PMMA) is known to influence post-operative inflammation." | 3.68 | Fibrinous uveitis and intraocular lens implantation. Surface modification of polymethylmethacrylate during extracapsular cataract surgery. ( Rose, GE, 1992) |
"The role of nerve conduction was studied in acute experimental uveitis caused by antidromic trigeminal nerve stimulation, prostaglandin E1 and E2 (PGE1 and PGE2), capsaicin and substance P (SP)." | 3.66 | Ocular responses to antidromic trigeminal stimulation, intracameral prostaglandin E1 and E2, capsaicin and substance P. ( Bill, A; Mandahl, A, 1981) |
"Following the induction of immunogenic uveitis betamethasone and dexamethasone reduced conjunctiva and iris hyperemia and aqueous flare." | 3.66 | Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. ( Bhattacherjee, P; Eakins, KE; Kulkarni, PS; Srinivasan, BD, 1981) |
"Acid phosphatase and beta-glucuronidase were used as marker enzymes of lysosome, and their role in adjuvant-induced uveitis was studied." | 3.66 | [The role of lysosomal enzymes in adjuvant-induced uveitis in rabbits (author's transl)]. ( Iso, T; Uda, K; Yamauchi, H, 1979) |
"To report a case with reactive arthritis (ReA) following Streptococcus viridans genitourinary infection." | 1.36 | Reactive arthritis following Streptococcus viridans urinary tract infection. ( Chen, JT; Chou, YS; Horng, CT; Hu, SC; Huang, HS; Tsai, ML, 2010) |
"The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems, which upon instillation as drops into the eye undergo a sol-gel transition in the cul-de-sac." | 1.32 | In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin. ( Balasubramaniam, J; Kant, S; Pandit, JK, 2003) |
" This formulation was evaluated for stability, bioavailability and anti-inflammatory activity in comparison with an ophthalmic IND solution currently on the market." | 1.31 | Pharmacokinetics and anti-inflammatory activity in rabbits of a novel indomethacin ophthalmic solution. ( Benelli, U; Burgalassi, S; Chetoni, P; Panichi, L; Saettone, MF, 2000) |
"Uveitis was induced by intravenous injection of E." | 1.29 | Effects of a combined use of steroidal and nonsteroidal anti-inflammatory drugs on E. coli endotoxin-induced uveitis in pigmented rabbits. ( Ogawa, T; Ohara, K; Shimizu, H; Terai, T; Watanabe, N, 1995) |
"The treatment with flurbiprofen and indomethacin administered subcutaneously every 12 hours, commenced on the day of S-antigen injection and was continued until the termination of the experiment (12 days)." | 1.28 | Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation. ( Bhattacherjee, P; Jaramillo, A; Paterson, CA; Sonnenfeld, G, 1992) |
"Patients with colitis or ileocolitis were more likely to suffer from ocular inflammation (23." | 1.28 | Ocular inflammation in Crohn's disease. ( Murray, AD; Salmon, JF; Wright, JP, 1991) |
"Indomethacin was the most effective inhibitor of prostaglandin (PG) E2 and PGF 2 alpha accumulation in the aqueous humor and their ex vivo production by the lens." | 1.27 | Effects of inhibitors of arachidonic acid metabolism on endotoxin-induced ocular inflammation. ( Fleisher, LN, 1988) |
"Indomethacin did not suppress the uveitis or circulating antibody production." | 1.26 | Ocular anti-inflammatory and systemic immunosuppressive effects of topically applied fluorometholone. ( Iso, T; Iwata, H; Yamauchi, H, 1979) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 30 (62.50) | 18.7374 |
1990's | 10 (20.83) | 18.2507 |
2000's | 4 (8.33) | 29.6817 |
2010's | 3 (6.25) | 24.3611 |
2020's | 1 (2.08) | 2.80 |
Authors | Studies |
---|---|
Zhang, Z | 1 |
Ma, X | 1 |
Xia, T | 1 |
Wu, Y | 1 |
Shi, S | 1 |
Lei, L | 1 |
Li, X | 1 |
Chen, H | 1 |
Lin, D | 1 |
Allegri, P | 1 |
Murialdo, U | 1 |
Peri, S | 1 |
Carniglia, R | 1 |
Crivelli, MG | 1 |
Compiano, S | 1 |
Autuori, S | 1 |
Mastromarino, A | 1 |
Zurria, M | 1 |
Marrazzo, G | 2 |
Bucolo, C | 1 |
Platania, CB | 1 |
Romano, GL | 1 |
Drago, F | 1 |
Salomone, S | 1 |
Chou, YS | 1 |
Horng, CT | 1 |
Huang, HS | 1 |
Hu, SC | 1 |
Chen, JT | 1 |
Tsai, ML | 1 |
Zamir, E | 1 |
Bodaghi, B | 1 |
Tugal-Tutkun, I | 1 |
See, RF | 1 |
Charlotte, F | 1 |
Wang, RC | 1 |
Wechsler, B | 1 |
LeHoang, P | 1 |
Anteby, I | 1 |
Rao, NA | 2 |
Balasubramaniam, J | 1 |
Kant, S | 1 |
Pandit, JK | 1 |
Szabó, A | 1 |
Farkas, A | 1 |
Vámos, R | 1 |
Bajor, T | 1 |
Hrabák, A | 1 |
Tuovinen, E | 1 |
Esilä, R | 1 |
Liesmaa, M | 1 |
Mandahl, A | 1 |
Bill, A | 1 |
Cousins, SW | 1 |
Guss, RB | 1 |
Howes, EL | 1 |
Rosenbaum, JT | 1 |
Sunada, A | 1 |
Kin, K | 1 |
Narumi, C | 1 |
Mizutani, T | 1 |
Miyanaga, Y | 1 |
Tsurimaki, Y | 1 |
Shimizu, H | 2 |
Kulkarni, PS | 1 |
Bhattacherjee, P | 2 |
Eakins, KE | 3 |
Srinivasan, BD | 1 |
Tsuboi, I | 1 |
Tanaka, H | 1 |
Nakao, M | 1 |
Shichijo, S | 1 |
Itoh, K | 1 |
Ogawa, T | 1 |
Ohara, K | 1 |
Terai, T | 1 |
Watanabe, N | 1 |
Shiels, IA | 1 |
Sanderson, SD | 1 |
Taylor, SM | 1 |
Chetoni, P | 1 |
Panichi, L | 1 |
Burgalassi, S | 1 |
Benelli, U | 1 |
Saettone, MF | 1 |
Bengtsson, E | 1 |
Bonnet, P | 1 |
Faure, JP | 1 |
Le Douarec, JC | 1 |
Floman, N | 1 |
Zor, U | 1 |
Bito, LZ | 1 |
Wallenstein, MC | 1 |
Yamauchi, H | 3 |
Iso, T | 3 |
Iwao, J | 1 |
Iwata, H | 2 |
Sacerdoti, G | 1 |
Severino, R | 1 |
Uda, K | 1 |
Kaplan, HJ | 1 |
Diamond, JG | 1 |
Brown, SA | 1 |
James, DG | 1 |
Neville, E | 1 |
Langley, DA | 1 |
Kass, MA | 1 |
Neufeld, AH | 1 |
Sears, ML | 1 |
Jaramillo, A | 1 |
Sonnenfeld, G | 1 |
Paterson, CA | 1 |
Rose, GE | 1 |
Salmon, JF | 1 |
Wright, JP | 1 |
Murray, AD | 1 |
Sawa, M | 1 |
Maĭchuk, IuF | 1 |
Kazachenko, MA | 1 |
Diadina, UV | 1 |
Denault, A | 1 |
Dimopoulos, MA | 1 |
Fitzcharles, MA | 1 |
Bonne, C | 1 |
Tissié, G | 1 |
Trong, HN | 1 |
Latour, E | 1 |
Coquelet, C | 1 |
Patchett, R | 1 |
Fernandez, MA | 1 |
Sevanian, A | 1 |
Kunkel, SL | 1 |
Marak, GE | 1 |
Fleisher, LN | 1 |
Kim, MK | 1 |
Chan, CC | 1 |
Nussenblatt, RB | 1 |
Palestine, AG | 1 |
Dottan, S | 1 |
Glerstein, S | 1 |
Naveh, N | 1 |
Henkind, P | 1 |
Gold, DH | 1 |
Lazar, M | 1 |
Weiner, MJ | 1 |
Leopold, IH | 1 |
Whitelocke, RA | 1 |
Bennett, A | 1 |
Mishima, K | 1 |
Shirai, A | 1 |
Hara, J | 1 |
Yamashita, S | 1 |
Tokuda, H | 2 |
Kamano, H | 1 |
Fukuzawa, H | 1 |
Minatoya, K | 1 |
Perkins, ES | 1 |
MacFaul, PA | 1 |
Baldwin, HA | 1 |
Borgmann, AR | 1 |
5 reviews available for indomethacin and Uveitis
Article | Year |
---|---|
Transport of prostaglandins across the blood-brain and blood-aqueous barriers and the physiological significance of these absorptive transport processes.
Topics: Action Potentials; Animals; Anterior Chamber; Aqueous Humor; Biological Transport, Active; Blood; Bl | 1977 |
Prostaglandin and non-prostaglandin mediated breeakdown of the blood-aqueous barrier.
Topics: Animals; Aqueous Humor; Aspirin; Blood; Capillary Permeability; Eye; Humans; Indomethacin; Intraocul | 1977 |
[Autoimmunity and ocular pathology: critical review].
Topics: Adrenal Cortex Hormones; Arthritis, Reactive; Aspirin; Autoimmune Diseases; Connective Tissue Diseas | 1979 |
Ocular manifestations of rheumatic disorders. Natural and iatrogenic.
Topics: Adrenal Cortex Hormones; Arteritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Chloroquine; Conjunc | 1973 |
Acute anterior uveitis and prostaglandins.
Topics: Acetaminophen; Administration, Topical; Animals; Anti-Inflammatory Agents; Aqueous Humor; Eye; Fluoc | 1973 |
4 trials available for indomethacin and Uveitis
Article | Year |
---|---|
Randomized, double-blind, placebo-controlled clinical trial on the efficacy of 0.5% indomethacin eye drops in uveitic macular edema.
Topics: Aged; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adminis | 2014 |
[Inhibitory effect of non-steroidal anti-inflammatory agents on experimentally induced uveitis and a clinical use of non-steroidal anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Clinical Trials as Topic; Eye Diseases; Humans; Indomethacin; Oxy | 1968 |
[Clinical and experimental studies on non-steroid anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Chymotrypsin; Clinical Trials as Topic; Eye Diseases; Humans; Ind | 1968 |
Indomethacin in the treatment of uveitis. A double-blind trial.
Topics: Adolescent; Arthritis, Reactive; Clinical Trials as Topic; Colitis, Ulcerative; Diabetes Complicatio | 1965 |
39 other studies available for indomethacin and Uveitis
Article | Year |
---|---|
A Novel Indomethacin-Tripeptide Hydrogel for Inhibiting Ocular Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Hydrogels; Indomethacin; Inflammation; Rabbits; Uveitis | 2021 |
Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Benzophenones; Bromobenzenes; C | 2014 |
Reactive arthritis following Streptococcus viridans urinary tract infection.
Topics: Adult; Arthritis, Reactive; Behcet Syndrome; Clindamycin; Humans; Indomethacin; Male; Prohibitins; S | 2010 |
Conjunctival ulcers in Behçet's disease.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, | 2003 |
In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin.
Topics: Animals; Biological Availability; Cornea; Delayed-Action Preparations; Disease Models, Animal; Indom | 2003 |
The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Citru | 2004 |
Experience of the use of indomethacin in inflammatory eye diseases.
Topics: Capsules; Choroiditis; Eye Diseases; Humans; Indomethacin; Iritis; Keratitis; Optic Neuritis; Retini | 1966 |
Ocular responses to antidromic trigeminal stimulation, intracameral prostaglandin E1 and E2, capsaicin and substance P.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Female; Indomethacin; Intraocular Pressure; Male; Miot | 1981 |
Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology.
Topics: Animals; Capillary Permeability; Cyproheptadine; Disease Models, Animal; Dose-Response Relationship, | 1984 |
[The role of leukotrienes in ocular inflammation report 2. The effect of anti-SRS-A substance (KC-404) on experimental uveitis in guinea pigs].
Topics: Animals; Dexamethasone; Female; Guinea Pigs; Indomethacin; Pyridines; SRS-A; Uveitis | 1984 |
[Indomethacin treatment in 3 cases of chronic and complicated Harada's disease].
Topics: Adult; Chronic Disease; Female; Humans; Indomethacin; Iris Diseases; Middle Aged; Pigmentation Disor | 1984 |
Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin.
Topics: Animals; Aqueous Humor; Betamethasone; Conjunctivitis; Dexamethasone; Disease Models, Animal; Eye; H | 1981 |
Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cells, Cultured; Clone Cells; Diclofenac; Di | 1995 |
Effects of a combined use of steroidal and nonsteroidal anti-inflammatory drugs on E. coli endotoxin-induced uveitis in pigmented rabbits.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 1995 |
Arterially perfused eye model of uveitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Ciliary Arteries; Clonixin; Complement C5a; | 1999 |
Pharmacokinetics and anti-inflammatory activity in rabbits of a novel indomethacin ophthalmic solution.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Biological Availability; Chemistry, | 2000 |
Studies on the mechanism of the breakdown of the blood-aqueous barrier in the rabbit eye.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Blood; Ciliary Body | 1977 |
Standardization of an experimental immune uveitis in the rabbit for topical testing of drugs.
Topics: Administration, Topical; Animals; Antibodies; Aqueous Humor; Arthus Reaction; Dexamethasone; Disease | 1976 |
Mechanism of steroid action in ocular inflammation: Inhibition of prostaglandin production.
Topics: Aldosterone; Animals; Aqueous Humor; Arachidonic Acids; Endotoxins; Escherichia coli; Glucocorticoid | 1977 |
The role of prostaglandins in experimental ocular inflammations.
Topics: Animals; Anterior Chamber; Aqueous Humor; Endophthalmitis; Endotoxins; Escherichia coli; Eye Protein | 1979 |
Ocular anti-inflammatory and systemic immunosuppressive effects of topically applied fluorometholone.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Antibody Formation; Dexamethasone; Fluor | 1979 |
[The role of lysosomal enzymes in adjuvant-induced uveitis in rabbits (author's transl)].
Topics: Acid Phosphatase; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease | 1979 |
Vitrectomy in experimental uveitis. I. Operative technique in rabbits.
Topics: Animals; Indomethacin; Inflammation; Lens, Crystalline; Methods; Postoperative Care; Postoperative C | 1979 |
Ocular sarcoidosis.
Topics: Adrenal Cortex Hormones; Adult; Chloroquine; Conjunctivitis; Eye Diseases; Eye Manifestations; Facia | 1976 |
Systemic aspirin and indomethacin do not prevent the response of the monkey eye to trauma.
Topics: Animals; Aqueous Humor; Arachidonic Acids; Aspirin; Dose-Response Relationship, Drug; Endotoxins; Ey | 1975 |
Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation.
Topics: Animals; Antigens; Arrestin; Autoantibodies; Dinoprostone; Disease Models, Animal; Eye Proteins; Fem | 1992 |
Fibrinous uveitis and intraocular lens implantation. Surface modification of polymethylmethacrylate during extracapsular cataract surgery.
Topics: Adult; Aged; Aged, 80 and over; Cataract Extraction; Female; Fibrin; Humans; Hypromellose Derivative | 1992 |
Ocular inflammation in Crohn's disease.
Topics: Adolescent; Adult; Aged; Anterior Eye Segment; Anti-Inflammatory Agents, Non-Steroidal; Child; Colit | 1991 |
Clinical application of laser flare-cell meter.
Topics: Acetazolamide; Adult; Age Factors; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous H | 1990 |
[Rengasil (pirprofen) in the treatment of inflammatory eye diseases].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Corneal Ulcer; Drug Evaluation; Human | 1990 |
Meningoencephalitis and peripheral neuropathy complicating adult Still's disease.
Topics: Adult; Arthritis, Juvenile; Aspirin; Female; Humans; Indomethacin; Meningoencephalitis; Peripheral N | 1990 |
Free radical scavenging capacity and anti-inflammatory activity of CBS-113 A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Free Radical Scavengers; Free Radic | 1990 |
Treatment of experimental granulomatous uveitis by lipoxygenase and cyclo-oxygenase inhibitors.
Topics: Animals; Crystallins; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Granuloma; Immune Com | 1987 |
Effects of inhibitors of arachidonic acid metabolism on endotoxin-induced ocular inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1988 |
Pharmacologic effects on the expression of class II histocompatibility antigen in experimental endotoxin-induced uveitis.
Topics: Animals; Colchicine; Cyclosporins; Dexamethasone; Elapid Venoms; Endotoxins; Female; Histocompatibil | 1987 |
Azathioprine-induced in vitro inhibition of prostaglandin E2 production by rabbit retina.
Topics: Animals; Azathioprine; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Prostagl | 1987 |
Treatment of uveitis with methotrexate.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Alopecia; Anti-Bacterial Agents; Child; | 1969 |
An improved immunogenic uveitis test in rabbits for evaluation of anti-inflammatory compounds.
Topics: Animals; Anti-Inflammatory Agents; Antigens; Blood; Corynebacterium; Dexamethasone; Female; Horses; | 1970 |
[Indication for non-steroidal anti-inflammatory drugs in ophthalmology].
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Betamethasone; Eye Diseases; Indomethaci | 1968 |