indomethacin has been researched along with Ulcer in 168 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin caused microcytic anaemia, hypoalbuminaemia, small intestinal ulceration, caecal ulceration and inconspicuous raised mucosal lesions in the caecum that histologically showed submucosal fibrosis with disruption and thickening of the apical muscularis mucosae." | 9.07 | Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin. ( Anthony, A; Dhillon, AP; Nygard, G; Pounder, RE; Sim, R; Wakefield, AJ, 1994) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 8.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "Unlike quercetin, chlorogenic acid could not prevent gastric ulcers in indomethacin-treated rats." | 8.31 | Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration. ( Angkhasirisap, W; Boonyong, C; Jianmongkol, S; Kengkoom, K, 2023) |
| "Indomethacin (INDO) induced intestinal injury and ulcer model in rats." | 8.31 | Limonin ameliorates indomethacin-induced intestinal damage and ulcers through Nrf2/ARE pathway. ( Jia, B; Li, M; Liu, P; Tian, Z; Zhao, L, 2023) |
| "7 g/kg) or ranitidine (40 mg/kg) were orally administered in rats for three weeks before the induction of gastric ulcer using indomethacin (30 mg/kg, single oral dose)." | 8.31 | Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats. ( Bai, L; Bao, M; Bao, T; Chen, Y; Feng, L; Fu, M; Li, Y; Mu, X; Ta, N; Zhang, J, 2023) |
| "We used the murine re-fed indomethacin (IND) experimental ulcer model." | 8.31 | Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT ( Akiba, Y; Kaunitz, JD; Satoh, H; Urushidani, T, 2023) |
| " In this study we demonstrate that expression levels of interleukin (IL)-18 are related to aggravation of intestinal ulcerogenic lesions in adjuvant-induced arthritis (AA) rats following oral administration of indomethacin." | 7.81 | Excessive Interleukin 18 Relate the Aggravation of Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rat. ( Ito, Y; Nagai, N; Tanino, T, 2015) |
| "Indomethacin treatment induced intestinal ulcers that gradually healed after treatment." | 7.80 | Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. ( Akiba, Y; Engel, E; Guth, PH; Higashiyama, M; Higuchi, K; Inoue, T; Kaji, I; Kaunitz, JD; Rudenkyy, S, 2014) |
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 7.79 | New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2013) |
| "The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP)." | 7.78 | Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity. ( Abdul Hisam, EE; Hasiah, AH; Norhafizah, M; Othman, F; Rofiee, MS; Vasudevan, M; Zakaria, ZA, 2012) |
| "To determine the potential antiulcer activity of methanol extract of Melastoma malabathricum leaves (MEMM) using various established rat models." | 7.78 | Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats. ( Hassan, H; Ismail, NA; Kamisan, FH; Mamat, SS; Mohtarrudin, N; Rodzi, R; Shamsahal Din, S; Somchit, MN; Wan Zainulddin, WN; Yahya, F; Zabidi, Z; Zakaria, ZA, 2012) |
| " Here, we investigated the possible role of α7 nicotinic acetylcholine receptors in the pathogenesis of indomethacin-induced small intestinal ulceration in mice." | 7.77 | Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice. ( Amagase, K; Hashimura, H; Kato, S; Kawahara, R; Takeuchi, K; Yasuda, M, 2011) |
| "Gastric ulcers were induced in mice with a single dose of indomethacin." | 7.76 | Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine. ( Bandyopadhyay, SK; Chatterjee, A; Chattopadhyay, S; Dey, A; Guha, P, 2010) |
| "The effect of lansoprazole, a proton pump inhibitor (PPI), on indomethacin-induced small intestinal ulceration was examined in rats, particularly in relation to heme oxygenase (HO)-1." | 7.76 | Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1. ( Amagase, K; Higuchi, K; Kakimoto, K; Kato, S; Murano, M; Nishio, H; Takeuchi, K; Tokioka, S; Umegaki, E; Yoda, Y, 2010) |
| "We examined the effect of tacrolimus (FK506), an immunosuppressive drug, on indomethacin-induced small intestinal ulceration in rats." | 7.74 | Tacrolimus (FK506), an immunosuppressive agent, prevents indomethacin-induced small intestinal ulceration in the rat: inhibition of inducible nitric oxide synthase expression. ( Kato, S; Nishio, H; Ogura, M; Takeuchi, K, 2007) |
| " Indomethacin (24 mg/kg/ day) was administered into the colon twice, 24 h apart, and intestinal ulcers in SC and LS groups were compared macroscopically." | 7.70 | Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats. ( Honda, K; Iida, M; Kuroki, F; Matsumoto, T; Oka, M; Sawatani, I, 1999) |
| "We investigated the pathogenic role of nitric oxide (NO) in indomethacin-induced intestinal ulceration in rats." | 7.70 | Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats. ( Kato, S; Kunikata, T; Mizoguchi, H; Takeuchi, K; Tanaka, A, 1999) |
| " We studied the effect of the oxygen radical scavengers superoxide dismutase (SOD), catalase (CAT), and allopurinol (ALLO) on indomethacin (INDO)-induced intestinal ulceration in the rat." | 7.69 | Oxygen radical scavengers are protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Fisher, S; Heckelman, B; Kiro, A; Marcus, H; Zahavi, I, 1995) |
| "We report mycobacterial granulomatous inflammation in the ulcerated caecum of rats that received indomethacin." | 7.69 | Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats. ( Anthony, A; Billington, O; Dhillon, AP; Fidler, H; McFadden, J; Nygard, G; Pounder, RE; Wakefield, AJ, 1995) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 7.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "Jejunal villi undergo early histological shortening and vascular injury in indomethacin-induced ulcerative enteropathy in the rat." | 7.69 | The beta 3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening. ( Anthony, A; Bahl, AK; Dhillon, AP; Oakley, IG; Piasecki, C; Pounder, RE; Spraggs, CF; Trevethick, MA; Wakefield, AJ, 1996) |
| "In indomethacin-induced jejunal ulceration in the rat, villi undergo both early microvascular injury and shortening that may involve activation of villous smooth muscle." | 7.69 | Pre-ulcerative villous contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study. ( Anthony, A; Dhillon, AP; Pounder, RE; Thrasivoulou, C; Wakefield, AJ, 1995) |
| "We previously showed that intravenous total parenteral nutrition supplemented with nucleosides and nucleotides (NS/NT) promoted ulcer healing in rats with indomethacin-induced ileitis." | 7.69 | Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis. ( Levine, RA; Loo, A; Magur, E; Nandi, J; Oler, A; Sukumar, P, 1997) |
| "Nitric oxide (NO) synthesized from L-arginine interacts with prostaglandins (PG) and sensory neuropeptides in the regulation of mucosal integrity, but the role of L-arginine, a substrate for NO-synthase, in gastroprotection and healing of chronic gastric ulcers has been little studied." | 7.69 | Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. ( Brzozowski, T; Drozdowicz, D; Kedra, D; Konturek, SJ; Sliwowski, Z; Zaczek, M, 1997) |
| "Indomethacin induces ulceration in the rat jejunum with sparing of the ileum." | 7.69 | Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 1997) |
| " We studied the effect of L-dopa and related substances on indomethacin-induced intestinal ulceration in the rat." | 7.68 | L-dopa is protective against indomethacin-induced small intestinal ulceration in the rat: possible role of an alpha-2-adrenergic mechanism. ( Dinari, G; Kiro, A; Marcus, H; Zahavi, I, 1992) |
| "Participation of microcirculatory disturbances, especially the role of 5-lipoxygenase products from neutrophils, was investigated in indomethacin (Indo)-induced ulcers of rat small intestine." | 7.68 | Microcirculatory disturbance in indomethacin-induced intestinal ulcer. ( Houzawa, S; Kurose, I; Miura, S; Nagata, H; Serizawa, H; Suematsu, M; Suzuki, M; Tanaka, S; Tsuchiya, M, 1991) |
| "We studied the effect of parenteral morphine and naloxone administration on intestinal mucosal Prostaglandin E2 (PGE2) and 3',5' cyclic adenosine monophosphate (cAMP) levels and on indomethacin-induced intestinal ulceration in the rat." | 7.68 | Modulation by opiates of small intestinal prostaglandin E2 and 3',5'cyclic adenosine monophosphate levels and of indomethacin-induced ulceration in the rat. ( Dinari, G; Ligumski, M; Marcus, H; Waisman, Y, 1991) |
| "The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers." | 7.67 | The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats. ( Beró, T; Jávor, T; Mózsik, G; Németh, A, 1984) |
| "Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats." | 7.67 | Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Ligumsky, M; Marcus, H; Nitzan, M; Rosenbach, Y; Waisman, Y; Zahavi, I, 1985) |
| "Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug." | 7.67 | Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. ( Fielder, FG; Ginsberg, RS; Godin-Ostro, E; Slusher, MA; Soehngen, EC; Weiner, AL, 1988) |
| "It has been developed a new simple method for the evaluation of intestinal ulceration induced by indomethacin or other drug in rats." | 7.67 | Quantitative analysis of intestinal ulceration induced by indomethacin, in rats. ( Ezer, E, 1987) |
| "Capsaicin desensitization increases degree and incidence of indomethacin-induced intestinal ulcers in rats, suggesting the existence of a capsaicin-sensitive mechanism(s) in the protection of the intestinal mucosa against indomethacin-induced ulceration." | 7.67 | Involvement of capsaicin-sensitive mechanism(s) in the antiulcer defence of intestinal mucosa in rats. ( Evangelista, S; Maggi, CA; Meli, A, 1987) |
| " FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug." | 7.67 | Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat. ( Barzanti, A; Ciappi, R; Evangelista, S; Meli, A; Ortolani, C, 1985) |
| "Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats." | 7.67 | Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985) |
| "Oral ulcers developed in three edentulous patients who were receiving indomethacin (Indocin) therapy for rheumatoid arthritis." | 7.65 | Oral ulcerations associated with indomethacin therapy: report of three cases. ( Guggenheimer, J; Ismail, YH, 1975) |
| "Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects." | 5.91 | Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1. ( El-Demerdash, E; Hamza, SE; Wahdan, SA, 2023) |
| "The prevalence of gastric ulcers is increasing worldwide, especially those brought on by non-steroidal anti-inflammatory drugs (NSAIDS), so prevention is extremely crucial." | 5.91 | Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats. ( Abu-Risha, SE; Elsisi, AE; Mekky, EF, 2023) |
| "Small intestinal ulcers are a serious adverse effect commonly occurring in patients taking nonsteroidal anti-inflammatory drugs." | 5.43 | Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Kawauchi, S; Mizuno, S; Nakamura, T; Rikitake, Y; Tanahashi, T, 2016) |
| " Vancomycin (VCM), a poorly absorbed drug, was administered intraduodenally to rats with SIUs." | 5.40 | Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Inoue, J; Kawauchi, S; Miki, I; Mizuno, S; Nakamura, T; Nishikawa, C; Tanahashi, T; Yasui, H, 2014) |
| "Indomethacin treatment markedly enhanced inducible nitric oxide synthase and chemokine mRNA expression in the small intestine, but these responses were all significantly attenuated by either domperidone or metoclopramide." | 5.37 | Dopamine D₂-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating α7 nicotinic acetylcholine receptors. ( Amagase, K; Hashimura, H; Iimori, M; Kato, S; Kawahara, R; Takeuchi, K; Yamanaka, N; Yasuda, M, 2011) |
| "Pre-treatment with rutin protected gastric tissues against indomethacin-induced gastropathy as demonstrated from reduction in the ulcer index, attenuation of histopathological changes and amelioration of the altered oxidative stress and biochemical parameters." | 5.36 | Gastroprotective effect of rutin against indomethacin-induced ulcers in rats. ( Abdel-Raheem, IT, 2010) |
| "Indomethacin was administered subcutaneously to rats, 4 mg/kg/day for 4 consecutive days in order to produce erosions of the small intestine which were scored at necropsy on day 5." | 5.27 | Diphenyldisulfide inhibits indomethacin-induced ulcerogenesis in rats. ( Tomolonis, AJ; Young, JM, 1987) |
| "Indomethacin-treated suckling animals prevented from weaning did not develop intestinal lesions until they had access to solid food on day 23." | 5.27 | Indomethacin fails to induce ulceration in the gastrointestinal tract of newborn and suckling rats. ( Bedrick, AD; Holtzapple, PG, 1986) |
| "Indomethacin caused microcytic anaemia, hypoalbuminaemia, small intestinal ulceration, caecal ulceration and inconspicuous raised mucosal lesions in the caecum that histologically showed submucosal fibrosis with disruption and thickening of the apical muscularis mucosae." | 5.07 | Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin. ( Anthony, A; Dhillon, AP; Nygard, G; Pounder, RE; Sim, R; Wakefield, AJ, 1994) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 4.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "Unlike quercetin, chlorogenic acid could not prevent gastric ulcers in indomethacin-treated rats." | 4.31 | Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration. ( Angkhasirisap, W; Boonyong, C; Jianmongkol, S; Kengkoom, K, 2023) |
| "), the gastroprotective activity was assessed in various animal models of stomach ulcers caused by acidified ethanol, water constraint stress, indomethacin, (acute), and acid acetic (chronic)." | 4.31 | Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves. ( Arunachalam, K; Damazo, AS; Figueiredo, FF; Lima, JCDS; Martins, DTO; Pavan, E; Silva, MJD, 2023) |
| " The therapeutic effect of AH seeds extract against indomethacin-induced ulcer in rat model indicated the regenerated membrane integrity, with improved cellular functions and mucus thickness." | 4.31 | Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis. ( Idris, S; Khushtar, M; Mishra, A, 2023) |
| "7 g/kg) or ranitidine (40 mg/kg) were orally administered in rats for three weeks before the induction of gastric ulcer using indomethacin (30 mg/kg, single oral dose)." | 4.31 | Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats. ( Bai, L; Bao, M; Bao, T; Chen, Y; Feng, L; Fu, M; Li, Y; Mu, X; Ta, N; Zhang, J, 2023) |
| "We used the murine re-fed indomethacin (IND) experimental ulcer model." | 4.31 | Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT ( Akiba, Y; Kaunitz, JD; Satoh, H; Urushidani, T, 2023) |
| " In the present study, we examined the effects of soluble dietary fibers on both anti-inflammatory and ulcerogenic effects of indomethacin in arthritic rats." | 3.83 | Soluble Dietary Fibers Can Protect the Small Intestinal Mucosa Without Affecting the Anti-inflammatory Effect of Indomethacin in Adjuvant-Induced Arthritis Rats. ( Hirakawa, T; Matsumoto, H; Satoh, H; Wada, N, 2016) |
| "Antiulcer assays were performed using ethanol, indomethacin and pylorus ligation-induced ulcer models at the dose of 50, 100 and 150 mg/kg, p." | 3.81 | Gastroprotective and antioxidant potentials of ethanolic stem bark extract of Margaritaria discoidea (Euphorbiaceae) in rats. ( Adetunde, TO; Orisaremi, CO; Sansaliyu, I; Sofidiya, MO, 2015) |
| " In this study we demonstrate that expression levels of interleukin (IL)-18 are related to aggravation of intestinal ulcerogenic lesions in adjuvant-induced arthritis (AA) rats following oral administration of indomethacin." | 3.81 | Excessive Interleukin 18 Relate the Aggravation of Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rat. ( Ito, Y; Nagai, N; Tanino, T, 2015) |
| "Indomethacin treatment induced intestinal ulcers that gradually healed after treatment." | 3.80 | Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. ( Akiba, Y; Engel, E; Guth, PH; Higashiyama, M; Higuchi, K; Inoue, T; Kaji, I; Kaunitz, JD; Rudenkyy, S, 2014) |
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 3.79 | New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2013) |
| "We examined changes in the expression of a pro-angiogenic factor, vascular endothelial growth factor (VEGF), and an anti-angiogenic factor, endostatin, as well as matrix metalloproteinase (MMP)-2 and MMP-9 in the rat small intestine after administration of indomethacin and investigated the roles of these factors in the healing of indomethacin-induced small intestinal ulcers." | 3.79 | Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats. ( Amagase, K; Gyenge, M; Kunimi, S; Matsuoka, R; Takeuchi, K, 2013) |
| "Antiulcerogenic activity of crude ethanolic extract of Celtis iguanaea leaves (CEE) was observed with experimental models such as ethanol, indomethacin, stress and pyloric ligation-induced gastric ulcers." | 3.79 | Preliminary studies of gastroprotective effect of Celtis iguanaea (Jacq.) Sargent leaves (Ulmaceae). ( Costa, EA; de Paula, JR; de Sousa, FB; do Couto, RO; Florentino, IF; Galdino, PM; Ghedini, PC; Martins, JL; Nascimento, MV, 2013) |
| "The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP)." | 3.78 | Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity. ( Abdul Hisam, EE; Hasiah, AH; Norhafizah, M; Othman, F; Rofiee, MS; Vasudevan, M; Zakaria, ZA, 2012) |
| "To determine the potential antiulcer activity of methanol extract of Melastoma malabathricum leaves (MEMM) using various established rat models." | 3.78 | Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats. ( Hassan, H; Ismail, NA; Kamisan, FH; Mamat, SS; Mohtarrudin, N; Rodzi, R; Shamsahal Din, S; Somchit, MN; Wan Zainulddin, WN; Yahya, F; Zabidi, Z; Zakaria, ZA, 2012) |
| " Here, we investigated the possible role of α7 nicotinic acetylcholine receptors in the pathogenesis of indomethacin-induced small intestinal ulceration in mice." | 3.77 | Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice. ( Amagase, K; Hashimura, H; Kato, S; Kawahara, R; Takeuchi, K; Yasuda, M, 2011) |
| " Derivatives 4a, 4b and 4c exhibited moderate to good anti-inflammatory and analgesic activity in carrageenan-induced rat paw edema and acetic acid-induced writhing in mice, respectively, with low ulcerogenicity compared with the standard drug indomethacin." | 3.76 | Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents. ( Gaba, M; Gaba, P; Sharma, V; Singh, D; Singh, S, 2010) |
| "Gastric ulcers were induced in mice with a single dose of indomethacin." | 3.76 | Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine. ( Bandyopadhyay, SK; Chatterjee, A; Chattopadhyay, S; Dey, A; Guha, P, 2010) |
| "The effect of lansoprazole, a proton pump inhibitor (PPI), on indomethacin-induced small intestinal ulceration was examined in rats, particularly in relation to heme oxygenase (HO)-1." | 3.76 | Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1. ( Amagase, K; Higuchi, K; Kakimoto, K; Kato, S; Murano, M; Nishio, H; Takeuchi, K; Tokioka, S; Umegaki, E; Yoda, Y, 2010) |
| "The role of dietary fibre (DF), intestinal motility and leukotrienes (LTs) in the formation of small intestinal ulcers induced by indomethacin (IND) was investigated in cats." | 3.75 | Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in cats. ( Hatao, K; Nishimura, S; Otsuka, N; Satoh, H; Shiotani, S, 2009) |
| "Intestinal ulcers were induced in rats by subcutaneous administration of indomethacin." | 3.75 | PET and macro- and microautoradiographic studies combined with immunohistochemistry for monitoring rat intestinal ulceration and healing processes. ( Kataoka, Y; Mizuma, H; Wada, Y; Watanabe, Y; Yamato, M, 2009) |
| "To evaluate anti-ulcer effect of estrogen and luteinising hormone (LH) on indomethacin-induced ulcer model in female rats." | 3.75 | Role of alpha-2 adrenergic receptors in anti-ulcer effect mechanism of estrogen and luteinising hormone on rats. ( Albayrak, F; Borekci, B; Cadirci, E; Halici, Z; Karaca, M; Kumtepe, Y; Polat, B; Suleyman, H, 2009) |
| " All the target compounds showed anti-inflammatory activity and three of them 3b, 3c and 4c surpassed that of indomethacin both locally and systemically in the cotton pellet granuloma and rat paw edema bioassay." | 3.74 | Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. ( Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D, 2008) |
| "We examined the effect of tacrolimus (FK506), an immunosuppressive drug, on indomethacin-induced small intestinal ulceration in rats." | 3.74 | Tacrolimus (FK506), an immunosuppressive agent, prevents indomethacin-induced small intestinal ulceration in the rat: inhibition of inducible nitric oxide synthase expression. ( Kato, S; Nishio, H; Ogura, M; Takeuchi, K, 2007) |
| "Rats receiving intracolonic administration of indomethacin develop longitudinal ulcers on the mesenteric side of the small intestine that are similar to those seen in the acute phase of Crohn's disease." | 3.74 | Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats. ( Haruma, K; Iida, M; Koga, H; Shimizu, K, 2007) |
| "The effect of irsogladine maleate, a widely used antiulcer drug in Japan, on indomethacin-induced small intestinal lesions was examined in rats." | 3.74 | Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats. ( Amagase, K; Hatazawa, R; Kamei, K; Kato, N; Kubo, Y; Takeuchi, K, 2008) |
| "The role of prostaglandins (PGs)/cyclooxygenase (COX) in the healing of indomethacin-induced small intestinal ulcers was examined in rats." | 3.73 | Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats. ( Hatazawa, R; Ohno, R; Takeuchi, K; Tanaka, A; Tanigami, M, 2006) |
| " In acetic acid-induced colitis in the rat, levels of malondialdehyde were found to be more markedly reduced with MED15 than with 5-aminosalicylic acid." | 3.72 | Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. ( Belogi, L; Bettelli, E; Mezzadri, CM; Tubaro, E, 2003) |
| "The effect of three new derivatives from dehydrocrotonin (DHC-compound I) on gastric damage in different animal models including gastric ulceration induced by a necrotic agent and hypothermic restrained-stress was studied: compound II (produced by reducing the cyclohexenone moiety of DHC with NaBH(4)); compound III (produced by reducing the carbonyls with LiAlH(4)); and compound IV (produced by transforming the lactone moiety into an amide)." | 3.72 | Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives. ( Durán, N; Haun, M; Hiruma-Lima, CA; Melo, PS; Souza-Brito, AR, 2003) |
| "Mother-reared and artificially fed infant rats demonstrated resistance to the ulcerogenic effects of indomethacin, in contrast to the adults." | 3.71 | Indomethacin, dexamethasone, and intestinal damage in infant rats. ( Clare-Salzler, M; DeMarco, VG; Li, YY; Neu, J; Patel, MR, 2002) |
| " Anti-inflammatory and ulcerogenic activities in vivo were evaluated and compared with the standard drugs, phenylbutazone and indomethacin." | 3.71 | Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes. ( Bansal, E; Kumar, A; Srivastava, VK, 2001) |
| " Inhibition of prostaglandin synthesis by traditional NSAIDs such as indomethacin and diclofenac which non-selectively inhibit both PGHS-1 and PGHS-2, causes gastric and intestinal ulceration and delays gastric ulcer healing in chronic models." | 3.70 | Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. ( Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T, 1998) |
| "Oral indomethacin causes villous shortening, microvascular damage, and distortion, which might induce mucosal ischaemia and necrosis." | 3.70 | Focal reduction of villous blood flow in early indomethacin enteropathy: a dynamic vascular study in the rat. ( Anthony, A; Dhillon, AP; Kelly, DA; Piasecki, C; Pounder, RE; Wakefield, AJ, 1998) |
| " Indomethacin (24 mg/kg/ day) was administered into the colon twice, 24 h apart, and intestinal ulcers in SC and LS groups were compared macroscopically." | 3.70 | Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats. ( Honda, K; Iida, M; Kuroki, F; Matsumoto, T; Oka, M; Sawatani, I, 1999) |
| "We investigated the pathogenic role of nitric oxide (NO) in indomethacin-induced intestinal ulceration in rats." | 3.70 | Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats. ( Kato, S; Kunikata, T; Mizoguchi, H; Takeuchi, K; Tanaka, A, 1999) |
| " We studied the effect of the oxygen radical scavengers superoxide dismutase (SOD), catalase (CAT), and allopurinol (ALLO) on indomethacin (INDO)-induced intestinal ulceration in the rat." | 3.69 | Oxygen radical scavengers are protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Fisher, S; Heckelman, B; Kiro, A; Marcus, H; Zahavi, I, 1995) |
| "We investigated the effect of dexamethasone on indomethacin-induced ulceration in the rat." | 3.69 | Dexamethasone promotes ulcer plugging in experimental enteritis. ( Anthony, A; Dhillon, AP; Pounder, RE; Sim, R; Wakefield, AJ, 1994) |
| "We report mycobacterial granulomatous inflammation in the ulcerated caecum of rats that received indomethacin." | 3.69 | Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats. ( Anthony, A; Billington, O; Dhillon, AP; Fidler, H; McFadden, J; Nygard, G; Pounder, RE; Wakefield, AJ, 1995) |
| "The effects of dietary pretreatment on longitudinal ulcers of the intestine induced by indomethacin given intracolonically were investigated in rats." | 3.69 | Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. ( Fujishima, M; Hizawa, K; Iida, M; Koga, H; Kuroki, F; Matsumoto, T, 1994) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 3.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "Jejunal villi undergo early histological shortening and vascular injury in indomethacin-induced ulcerative enteropathy in the rat." | 3.69 | The beta 3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening. ( Anthony, A; Bahl, AK; Dhillon, AP; Oakley, IG; Piasecki, C; Pounder, RE; Spraggs, CF; Trevethick, MA; Wakefield, AJ, 1996) |
| "In indomethacin-induced jejunal ulceration in the rat, villi undergo both early microvascular injury and shortening that may involve activation of villous smooth muscle." | 3.69 | Pre-ulcerative villous contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study. ( Anthony, A; Dhillon, AP; Pounder, RE; Thrasivoulou, C; Wakefield, AJ, 1995) |
| "We previously showed that intravenous total parenteral nutrition supplemented with nucleosides and nucleotides (NS/NT) promoted ulcer healing in rats with indomethacin-induced ileitis." | 3.69 | Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis. ( Levine, RA; Loo, A; Magur, E; Nandi, J; Oler, A; Sukumar, P, 1997) |
| "Nitric oxide (NO) synthesized from L-arginine interacts with prostaglandins (PG) and sensory neuropeptides in the regulation of mucosal integrity, but the role of L-arginine, a substrate for NO-synthase, in gastroprotection and healing of chronic gastric ulcers has been little studied." | 3.69 | Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. ( Brzozowski, T; Drozdowicz, D; Kedra, D; Konturek, SJ; Sliwowski, Z; Zaczek, M, 1997) |
| "Indomethacin induces ulceration in the rat jejunum with sparing of the ileum." | 3.69 | Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 1997) |
| "Indomethacin, a nonsteroidal anti-inflammatory drug, induces the formation of gastrointestinal ulceration both in experimental animals and in humans." | 3.68 | Structural and morphometric analysis of murine small intestine after indomethacin administration. ( Carr, KE; Ettarh, RR, 1993) |
| " We studied the effect of L-dopa and related substances on indomethacin-induced intestinal ulceration in the rat." | 3.68 | L-dopa is protective against indomethacin-induced small intestinal ulceration in the rat: possible role of an alpha-2-adrenergic mechanism. ( Dinari, G; Kiro, A; Marcus, H; Zahavi, I, 1992) |
| "Participation of microcirculatory disturbances, especially the role of 5-lipoxygenase products from neutrophils, was investigated in indomethacin (Indo)-induced ulcers of rat small intestine." | 3.68 | Microcirculatory disturbance in indomethacin-induced intestinal ulcer. ( Houzawa, S; Kurose, I; Miura, S; Nagata, H; Serizawa, H; Suematsu, M; Suzuki, M; Tanaka, S; Tsuchiya, M, 1991) |
| "We studied the effect of parenteral morphine and naloxone administration on intestinal mucosal Prostaglandin E2 (PGE2) and 3',5' cyclic adenosine monophosphate (cAMP) levels and on indomethacin-induced intestinal ulceration in the rat." | 3.68 | Modulation by opiates of small intestinal prostaglandin E2 and 3',5'cyclic adenosine monophosphate levels and of indomethacin-induced ulceration in the rat. ( Dinari, G; Ligumski, M; Marcus, H; Waisman, Y, 1991) |
| "The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers." | 3.67 | The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats. ( Beró, T; Jávor, T; Mózsik, G; Németh, A, 1984) |
| " Pelsonin a combination of indomethacin and sodium salicylate (1:10 ratio) has a cytoprotective effect against acidic-alcohol induced gastric necrosis, and it does not induce intestinal ulceration." | 3.67 | Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat. ( Ezer, E; Matuz, J; Pallagi, K; Szporny, L, 1984) |
| "The effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on various experimental gastric ulcers and gastric secretion in experimental animals was compared with that of cimetidine and cetraxate." | 3.67 | Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals. ( Aratani, S; Enomoto, H; Kimura, K; Mimura, K; Nomura, A; Ueda, F, 1984) |
| " We now show that DPPE profoundly inhibits restraint and cold stress and ethanol-induced gastric ulcer formation, accelerates ulcer healing, attenuates the stress-induced rise in plasma corticosterone level, and significantly reduces basal and H2 agonist (dimaprit)-stimulated and, to a lesser extent, bethanechol-stimulated gastric acid output in conscious rats." | 3.67 | Antiulcerogenic and antisecretory effects of a novel diphenylmethane derivative and antiestrogen binding site ligand. ( Brandes, LJ; Glavin, GB, 1988) |
| "Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats." | 3.67 | Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Ligumsky, M; Marcus, H; Nitzan, M; Rosenbach, Y; Waisman, Y; Zahavi, I, 1985) |
| " On the other hand, protective effects of PGM on diarrhea induced by arachidonic acid in mice were about 1/2 times as potent as those of IND in both 1 and 4 hr pretreatments." | 3.67 | [Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract]. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1986) |
| "The intestinal ulcerogenic activity of the weak prostaglandin synthesis inhibitor drug Wy-41,770 [5H-dibenzo(a,d)-cyclohepten-5-ylidine] was contrasted with the potent synthesis inhibitor, indomethacin, in rats to establish the relationship of inhibition of prostaglandin synthesis to the intestinal damage." | 3.67 | Mucosal lesions induced in the rat intestinal tract by the anti-inflammatory drug, Wy-41,770, a weak inhibitor of prostaglandin synthesis, contrasted with those from the potent prostaglandin inhibitor, indomethacin. ( Rainsford, KD, 1988) |
| "Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug." | 3.67 | Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. ( Fielder, FG; Ginsberg, RS; Godin-Ostro, E; Slusher, MA; Soehngen, EC; Weiner, AL, 1988) |
| "1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido 1,2-a pyrimidine-3-carboxamide (Ch-127) significantly inhibited the intestinal ulceration induced by a single dose of indomethacin (15 mg/kg p." | 3.67 | 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks' daily administration of indomethacin. ( Gyires, K; Hermecz, I; Knoll, J, 1987) |
| "It has been developed a new simple method for the evaluation of intestinal ulceration induced by indomethacin or other drug in rats." | 3.67 | Quantitative analysis of intestinal ulceration induced by indomethacin, in rats. ( Ezer, E, 1987) |
| "Capsaicin desensitization increases degree and incidence of indomethacin-induced intestinal ulcers in rats, suggesting the existence of a capsaicin-sensitive mechanism(s) in the protection of the intestinal mucosa against indomethacin-induced ulceration." | 3.67 | Involvement of capsaicin-sensitive mechanism(s) in the antiulcer defence of intestinal mucosa in rats. ( Evangelista, S; Maggi, CA; Meli, A, 1987) |
| " FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug." | 3.67 | Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat. ( Barzanti, A; Ciappi, R; Evangelista, S; Meli, A; Ortolani, C, 1985) |
| "Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats." | 3.67 | Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985) |
| "An ulcerative enterocolitis was induced in dogs by two drugs; cinchophen given intravenously or indomethacin given orally." | 3.66 | Ulcerative enterocolitis in dogs induced by drugs. ( Hetenyi, C; Orizaga, M; Rowsell, H; Stewart, TH, 1980) |
| " Afterwards the different seriousness of the ulcerative lesions caused by indomethacin on normal rats and on rats kept on a diet lack of precursors of prostaglandins is weighed." | 3.66 | [Effects of indomethacin on rats kept on a normal diet and on a diet without prostaglandin precursors]. ( Agosti, C; Fasce, L; Gianfranceschi, P; Ragazzini, G, 1980) |
| "Indomethacin given orally to conventional rats produced in three days a syndrome, often fatal, of intestinal lesions characterized by multiple ulcers and peritonitis." | 3.65 | Resistance of germfree rats to indomethacin-induced intestinal lesions. ( Asano, T; Robert, A, 1977) |
| "Oral ulcers developed in three edentulous patients who were receiving indomethacin (Indocin) therapy for rheumatoid arthritis." | 3.65 | Oral ulcerations associated with indomethacin therapy: report of three cases. ( Guggenheimer, J; Ismail, YH, 1975) |
| " To investigate the mechanism of action, conducted assays of antioxidant activity, measured the dosage of inflammatory cytokines, quantified mucus, treated with inhibitors (IND, L-NAME, glibenclamide, and yohimbine), performed histopathological analysis, and measured gastric acid secretion." | 2.44 | Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models. ( Arunachalam, K; Damazo, AS; Figueiredo, FF; Martins, DTO; Muller, JAI; Oliveira, DM; Serio, BFD; Silva, MJD; Venturini, CL, 2024) |
| "Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects." | 1.91 | Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1. ( El-Demerdash, E; Hamza, SE; Wahdan, SA, 2023) |
| "The prevalence of gastric ulcers is increasing worldwide, especially those brought on by non-steroidal anti-inflammatory drugs (NSAIDS), so prevention is extremely crucial." | 1.91 | Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats. ( Abu-Risha, SE; Elsisi, AE; Mekky, EF, 2023) |
| "Small intestinal ulcers are a serious adverse effect commonly occurring in patients taking nonsteroidal anti-inflammatory drugs." | 1.43 | Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Kawauchi, S; Mizuno, S; Nakamura, T; Rikitake, Y; Tanahashi, T, 2016) |
| "When indomethacin (3 mg/kg) was administered after a morning meal (fed condition) for 7 days, it produced many lesions in the small intestine." | 1.43 | Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs. ( Idaka, S; Ishigami, K; Kondo, R; Satoh, H; Shinoda, T; Shiotani, S, 2016) |
| " Vancomycin (VCM), a poorly absorbed drug, was administered intraduodenally to rats with SIUs." | 1.40 | Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Inoue, J; Kawauchi, S; Miki, I; Mizuno, S; Nakamura, T; Nishikawa, C; Tanahashi, T; Yasui, H, 2014) |
| "Indomethacin treatment markedly enhanced inducible nitric oxide synthase and chemokine mRNA expression in the small intestine, but these responses were all significantly attenuated by either domperidone or metoclopramide." | 1.37 | Dopamine D₂-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating α7 nicotinic acetylcholine receptors. ( Amagase, K; Hashimura, H; Iimori, M; Kato, S; Kawahara, R; Takeuchi, K; Yamanaka, N; Yasuda, M, 2011) |
| "Pre-treatment with rutin protected gastric tissues against indomethacin-induced gastropathy as demonstrated from reduction in the ulcer index, attenuation of histopathological changes and amelioration of the altered oxidative stress and biochemical parameters." | 1.36 | Gastroprotective effect of rutin against indomethacin-induced ulcers in rats. ( Abdel-Raheem, IT, 2010) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| " Twenty-four hours later, they were dosed with indomethacin." | 1.34 | Role of bile in pathogenesis of indomethacin-induced enteropathy. ( Bjarnason, I; Foster, R; Jacob, M; Sigthorsson, G; Simpson, R, 2007) |
| " The severity of the toxicity (macroscopic ulcerations) in the stomach following oral dosing with [Zn2(Indo)4(DMF)2] was not significantly lower than that induced by IndoH (P = 0." | 1.32 | Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin. ( Biffin, JR; Davies, NM; Dillon, CT; Hambley, TW; Kennedy, BJ; Lay, PA; Regtop, HL; Zhou, Q, 2003) |
| " The toxic effects of nonsteroidal anti-inflammatory drugs for the lower gastrointestinal tract share certain features with inflammatory processes, suggesting that the release of inflammation cytokines such as TNF-alpha may damage the intestine." | 1.30 | Increase in tumor necrosis factor-alpha production linked to the toxicity of indomethacin for the rat small intestine. ( Bertrand, V; Chaussade, S; Chauvelot-Moachon, L; Couturier, D; Giroud, JP; Guimbaud, R; Mauprivez, C; Sogni, P; Tulliez, M, 1998) |
| " A preliminary bioavailability study of two of the lead structures is presented." | 1.27 | Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents. ( Blythin, DJ; Bober, LA; Chiu, PJ; Conn, DJ; Domalski, MS; Kaminski, JJ; Solomon, DM; Spitler, J; Verbiar, LL; Wong, SC, 1986) |
| " It was shown that (1) all tested compounds inhibited the number and severity of the intestinal mucosal lesions, however, to different extent; (2) the inhibition of the development of small intestinal mucosal damage displayed a dose-response relationship; (3) 17-aza-PGF2 alpha was found to have the most potent effect on the development of the intestinal lesions as well as on the development of gastric mucosal damage produced by ethanol." | 1.27 | Preventive effect of PGI2, 7-oxo-PGI2 and 17-aza-PGF2 alpha derivate on the development of indomethacin-induced intestinal mucosal damage in rats. ( Beró, T; Garamszegi, M; Jávor, T; Mózsik, G, 1984) |
| "Indomethacin was administered subcutaneously to rats, 4 mg/kg/day for 4 consecutive days in order to produce erosions of the small intestine which were scored at necropsy on day 5." | 1.27 | Diphenyldisulfide inhibits indomethacin-induced ulcerogenesis in rats. ( Tomolonis, AJ; Young, JM, 1987) |
| "Indomethacin-treated suckling animals prevented from weaning did not develop intestinal lesions until they had access to solid food on day 23." | 1.27 | Indomethacin fails to induce ulceration in the gastrointestinal tract of newborn and suckling rats. ( Bedrick, AD; Holtzapple, PG, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (32.74) | 18.7374 |
| 1990's | 32 (19.05) | 18.2507 |
| 2000's | 31 (18.45) | 29.6817 |
| 2010's | 36 (21.43) | 24.3611 |
| 2020's | 14 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kurokawa, M | 1 |
| Uno, H | 1 |
| Nakamura, H | 2 |
| Sato, F | 1 |
| Naruto, S | 1 |
| Blythin, DJ | 1 |
| Kaminski, JJ | 1 |
| Domalski, MS | 1 |
| Spitler, J | 1 |
| Solomon, DM | 1 |
| Conn, DJ | 1 |
| Wong, SC | 1 |
| Verbiar, LL | 1 |
| Bober, LA | 1 |
| Chiu, PJ | 1 |
| Auzzi, G | 1 |
| Bruni, F | 1 |
| Cecchi, L | 1 |
| Costanzo, A | 1 |
| Vettori, LP | 1 |
| Pirisino, R | 1 |
| Corrias, M | 1 |
| Ignesti, G | 1 |
| Banchelli, G | 1 |
| Raimondi, L | 1 |
| Bekhit, AA | 2 |
| Ashour, HM | 1 |
| Abdel Ghany, YS | 1 |
| Bekhit, Ael-D | 1 |
| Baraka, A | 1 |
| Sharma, M | 2 |
| Ray, SM | 2 |
| Chikhale, RV | 1 |
| Bhole, RP | 1 |
| Khedekar, PB | 1 |
| Bhusari, KP | 1 |
| Amin, KM | 2 |
| Hanna, MM | 2 |
| Abo-Youssef, HE | 1 |
| George, RF | 2 |
| Aytaç, SP | 1 |
| Tozkoparan, B | 1 |
| Kaynak, FB | 1 |
| Aktay, G | 1 |
| Göktaş, O | 1 |
| Unüvar, S | 1 |
| Bhandari, SV | 2 |
| Dangre, SC | 1 |
| Bothara, KG | 2 |
| Patil, AA | 1 |
| Sarkate, AP | 1 |
| Lokwani, DK | 2 |
| Gore, ST | 1 |
| Deshmane, BJ | 1 |
| Raparti, VT | 1 |
| Khachane, CV | 1 |
| Kamel, MM | 1 |
| Anwar, MM | 1 |
| Khedr, M | 1 |
| Syam, YM | 1 |
| Gaba, M | 1 |
| Singh, D | 1 |
| Singh, S | 1 |
| Sharma, V | 1 |
| Gaba, P | 1 |
| Rizk, OH | 1 |
| Shaaban, OG | 1 |
| El-Ashmawy, IM | 1 |
| Giles, D | 1 |
| Roopa, K | 1 |
| Sheeba, FR | 1 |
| Gurubasavarajaswamy, PM | 1 |
| Divakar, G | 1 |
| Vidhya, T | 1 |
| Abdel-Aziz, M | 1 |
| Abuo-Rahma, Gel-D | 1 |
| Beshr, EA | 1 |
| Ali, TF | 1 |
| Abdellatif, KR | 1 |
| Abdelgawad, MA | 1 |
| Labib, MB | 1 |
| Zidan, TH | 1 |
| Banerjee, AG | 1 |
| Das, N | 1 |
| Shengule, SA | 1 |
| Sharma, PA | 1 |
| Srivastava, RS | 1 |
| Shrivastava, SK | 1 |
| Elshemy, HAH | 1 |
| Abdelall, EKA | 2 |
| Azouz, AA | 3 |
| Moawad, A | 1 |
| Ali, WAM | 1 |
| Safwat, NM | 1 |
| Abdelhamid, AO | 1 |
| Panda, SS | 1 |
| Girgis, AS | 1 |
| Thomas, SJ | 1 |
| Capito, JE | 1 |
| Salman, A | 1 |
| El-Manawaty, MA | 1 |
| Samir, A | 1 |
| Mohamed, YT | 1 |
| Naguib, IA | 1 |
| Abo-Saif, AA | 1 |
| Elkomy, MH | 1 |
| Alghamdi, BS | 1 |
| Mohamed, WR | 1 |
| Balaha, MF | 2 |
| Almalki, ZS | 1 |
| Alahmari, AK | 1 |
| Ahmed, NJ | 1 |
| Abd-Eldayem, AM | 1 |
| Alnasser, SM | 1 |
| Abd-Elhafeez, HH | 1 |
| Soliman, SA | 1 |
| Abdel-Emam, RA | 1 |
| Boonyong, C | 1 |
| Angkhasirisap, W | 1 |
| Kengkoom, K | 1 |
| Jianmongkol, S | 1 |
| Hamza, SE | 1 |
| Wahdan, SA | 1 |
| El-Demerdash, E | 1 |
| Jia, B | 1 |
| Zhao, L | 1 |
| Liu, P | 1 |
| Li, M | 1 |
| Tian, Z | 1 |
| Figueiredo, FF | 2 |
| Damazo, AS | 2 |
| Arunachalam, K | 2 |
| Silva, MJD | 2 |
| Pavan, E | 1 |
| Lima, JCDS | 1 |
| Martins, DTO | 2 |
| Elsisi, AE | 1 |
| Mekky, EF | 1 |
| Abu-Risha, SE | 1 |
| Idris, S | 1 |
| Mishra, A | 1 |
| Khushtar, M | 1 |
| Feng, L | 1 |
| Bao, T | 1 |
| Bai, L | 1 |
| Mu, X | 1 |
| Ta, N | 1 |
| Bao, M | 1 |
| Li, Y | 1 |
| Zhang, J | 1 |
| Fu, M | 1 |
| Chen, Y | 1 |
| Venturini, CL | 1 |
| Muller, JAI | 1 |
| Oliveira, DM | 1 |
| Serio, BFD | 1 |
| Satoh, H | 5 |
| Akiba, Y | 2 |
| Urushidani, T | 1 |
| Kaunitz, JD | 2 |
| Shabaan, MA | 1 |
| Kamal, AM | 1 |
| Faggal, SI | 1 |
| Elsahar, AE | 1 |
| Mohamed, KO | 1 |
| Bakr, RB | 1 |
| Ghoneim, AA | 1 |
| Gyenge, M | 1 |
| Amagase, K | 6 |
| Kunimi, S | 1 |
| Matsuoka, R | 1 |
| Takeuchi, K | 11 |
| Inoue, T | 1 |
| Higashiyama, M | 1 |
| Kaji, I | 1 |
| Rudenkyy, S | 1 |
| Higuchi, K | 2 |
| Guth, PH | 1 |
| Engel, E | 1 |
| Kawauchi, S | 2 |
| Nakamura, T | 2 |
| Yasui, H | 1 |
| Nishikawa, C | 1 |
| Miki, I | 1 |
| Inoue, J | 1 |
| Horibe, S | 2 |
| Hamaguchi, T | 2 |
| Tanahashi, T | 2 |
| Mizuno, S | 2 |
| Sofidiya, MO | 1 |
| Orisaremi, CO | 1 |
| Sansaliyu, I | 1 |
| Adetunde, TO | 1 |
| Higashimori, A | 1 |
| Watanabe, T | 1 |
| Nadatani, Y | 1 |
| Takeda, S | 1 |
| Otani, K | 1 |
| Tanigawa, T | 1 |
| Yamagami, H | 1 |
| Shiba, M | 1 |
| Tominaga, K | 1 |
| Fujiwara, Y | 1 |
| Arakawa, T | 2 |
| Matsumoto, H | 1 |
| Hirakawa, T | 1 |
| Wada, N | 1 |
| Nagai, N | 1 |
| Tanino, T | 1 |
| Ito, Y | 1 |
| Wallace, JL | 1 |
| Rikitake, Y | 1 |
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3 reviews available for indomethacin and Ulcer
| Article | Year |
|---|---|
Role of dietary fiber in formation and prevention of small intestinal ulcers induced by nonsteroidal anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fiber; Eating; Gastrointestinal Motility; | 2010 |
Erosive arthritis in a patient with Behçet's disease.
Topics: Adult; Antirheumatic Agents; Arthritis; Behcet Syndrome; Colchicine; Female; Genitalia, Female; Gluc | 2003 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact | 1980 |
1 trial available for indomethacin and Ulcer
| Article | Year |
|---|---|
Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin.
Topics: Administration, Oral; Anemia, Iron-Deficiency; Animals; Cecal Diseases; Cecum; Fibrosis; Indomethaci | 1994 |
164 other studies available for indomethacin and Ulcer
| Article | Year |
|---|---|
Synthesis and antiinflammatory activity of cis- and trans-6,6a,7,8,9,10,10a,11-octahydro-11-oxodibenzo[b,e]thiepinacetic and -oxepinacetic acids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry; Drug D | 1990 |
Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Biological Availability; Cyclooxygenase Inhibitors; Ga | 1986 |
2-Phenylpyrazolo[1,5-a]pyrimidin-7-ones. A new class of nonsteroidal antiinflammatory drugs devoid of ulcerogenic activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male; Phenylbutazone; Pyrazoles; Pyr | 1983 |
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; C | 2008 |
Synthesis and biological evaluation of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid as anti-inflammatory agents with reduced gastrointestinal ulcerogenecity.
Topics: Acetates; Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthri | 2008 |
Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid as anti-inflammatory agents free of ulcerogenic liability.
Topics: Acetates; Amides; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Carrageenan; Cytochrome | 2007 |
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
Synthesis, analgesic and anti-inflammatory activities evaluation of some bi-, tri- and tetracyclic condensed pyrimidines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Crystallography, X-Ray; Edema; Mice; Models, Molecula | 2009 |
Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Edema; Female; Male; Mice; | 2009 |
Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Edema; Female; Male; Mice; Model | 2009 |
Synthesis, biological evaluation and molecular docking of novel series of spiro [(2H,3H) quinazoline-2,1'- cyclohexan]-4(1H)- one derivatives as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclohexanes; Cyclohexanones; Cyclooxygenase 2; Edema | 2010 |
Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzimidazoles; Carrageenan; Edema; Male; Mice; Rats; | 2010 |
New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cy | 2012 |
Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Drug Design; Edema; Formaldehyde | 2012 |
Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agen | 2012 |
New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Edema; Hu | 2013 |
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 I | 2015 |
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2016 |
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclization; Cycl | 2017 |
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Ede | 2017 |
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2020 |
Role of ADMA/DDAH-1 and iNOS/eNOS signaling in the gastroprotective effect of tadalafil against indomethacin-induced gastric injury.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Indomethacin; Nitric Ox | 2022 |
AMPK/mTOR-driven autophagy & Nrf2/HO-1 cascade modulation by amentoflavone ameliorates indomethacin-induced gastric ulcer.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Biflavonoids; Gastric Mucosa; Indomethacin; Male; | 2022 |
Therapeutic Versus Preventative Use of
Topics: Animals; Cyclooxygenase 2; Cytokines; Ginkgo biloba; Indomethacin; Mice; Plant Extracts; Proliferati | 2022 |
Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration.
Topics: Animals; bcl-2-Associated X Protein; Caco-2 Cells; Chlorogenic Acid; Dinoprostone; Humans; Indometha | 2023 |
Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1.
Topics: Animals; Indomethacin; Rats; Stomach Ulcer; Tumor Necrosis Factor-alpha; Ulcer; Vitamin K 1 | 2023 |
Limonin ameliorates indomethacin-induced intestinal damage and ulcers through Nrf2/ARE pathway.
Topics: Animals; Indomethacin; Intestines; Limonins; Molecular Docking Simulation; NF-E2-Related Factor 2; R | 2023 |
Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves.
Topics: Adenosine Triphosphate; Animals; Anti-Ulcer Agents; Apigenin; Bignoniaceae; Ethanol; Gastritis; Indo | 2023 |
Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats.
Topics: Animals; Carbon Monoxide; Cyclooxygenase 2; Gastric Mucosa; Indomethacin; NF-E2-Related Factor 2; Ra | 2023 |
Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis.
Topics: Aesculus; Animals; Antioxidants; Glutathione; Indomethacin; Phytochemicals; Plant Extracts; Prostagl | 2023 |
Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats.
Topics: Animals; Gastrointestinal Microbiome; Indomethacin; Medicine, Mongolian Traditional; Metabolomics; R | 2023 |
Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cytokines; Ethanol; Indomethacin; Mice; Models, Theoretica | 2024 |
Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Apomorphine; Atropine; Bile Reflux; C | 2023 |
Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Celecoxi | 2020 |
Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2019 |
Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endostatins; Indomethacin; Intestinal Diseases; In | 2013 |
Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats.
Topics: Administration, Oral; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipeptidyl-Peptidas | 2014 |
Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassett | 2014 |
Gastroprotective and antioxidant potentials of ethanolic stem bark extract of Margaritaria discoidea (Euphorbiaceae) in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biphenyl Compounds; Ethanol; Euphorbiaceae; Gastric Mucosa | 2015 |
Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 1; Cells, Cultured; Disease Models, Animal | 2016 |
Soluble Dietary Fibers Can Protect the Small Intestinal Mucosa Without Affecting the Anti-inflammatory Effect of Indomethacin in Adjuvant-Induced Arthritis Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cytoprotection; Dietary F | 2016 |
Excessive Interleukin 18 Relate the Aggravation of Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Caco-2 Cells; Foot; Human | 2015 |
Prevention of NSAID-Enteropathy: A Soluble Problem?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dietary Fiber; Galactans; | 2016 |
Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytochrome P-450 CYP3A; Disease Models, Animal; Do | 2016 |
Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Dietary Fiber; Dietary Supplements; Dog | 2016 |
Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in cats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Diet; Dietary Fiber; Duodenal Ulcer; Eating; | 2009 |
PET and macro- and microautoradiographic studies combined with immunohistochemistry for monitoring rat intestinal ulceration and healing processes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoradiography; Fluorine Radioisotopes; Fluorodeo | 2009 |
Role of alpha-2 adrenergic receptors in anti-ulcer effect mechanism of estrogen and luteinising hormone on rats.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Anim | 2009 |
Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine.
Topics: Animals; Antineoplastic Agents; Arginine; Cyclooxygenase 1; Cyclooxygenase 2; Indomethacin; Male; Mi | 2010 |
Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Gastrointestinal Diseases | 2010 |
Adaptation of rat gastric tissue against indomethacin toxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cyclooxygenase 1; Cyclooxygenase 2; | 2010 |
Gastroprotective effect of rutin against indomethacin-induced ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Female; Gastric Mucosa; Glutathione; I | 2010 |
Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Basic-Leucine Zipper Transcription Factors; Chemok | 2009 |
Exacerbation of indomethacin-induced small intestinal injuries in Reg I-knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Interleukin-1beta; Intestinal Diseas | 2010 |
Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colony Co | 2010 |
Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, | 2011 |
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic | 2011 |
Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency.
Topics: Animals; Apoptosis; Basic-Leucine Zipper Transcription Factors; Caspase 3; Enzyme Activation; Enzyme | 2011 |
Dopamine D₂-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating α7 nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2011 |
Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity.
Topics: Animals; Bauhinia; Dose-Response Relationship, Drug; Gastrointestinal Agents; Indomethacin; Male; Me | 2012 |
Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats.
Topics: Animals; Dose-Response Relationship, Drug; Gastrointestinal Agents; Indomethacin; Male; Melastomatac | 2012 |
Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Ulcer Agents; Benzamides; Fencloni | 2012 |
Preliminary studies of gastroprotective effect of Celtis iguanaea (Jacq.) Sargent leaves (Ulmaceae).
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Gastrointestina | 2013 |
Indomethacin, dexamethasone, and intestinal damage in infant rats.
Topics: Age Factors; Animals; Animals, Suckling; Cyclooxygenase Inhibitors; Dexamethasone; Female; Food, For | 2002 |
Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cecum; Copper; Edema; Electron Spin R | 2003 |
Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug.
Topics: Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; | 2003 |
Conjunctival ulcers in Behçet's disease.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, | 2003 |
Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives.
Topics: Animals; Anti-Ulcer Agents; Croton; Diterpenes; Diterpenes, Clerodane; Ethanol; Hydrochloric Acid; H | 2003 |
The effects of lectins on indomethacin-induced small intestinal ulceration.
Topics: Animals; Cell Division; Concanavalin A; Food, Formulated; Indomethacin; Intestinal Diseases; Intesti | 2003 |
An unusual cause of rectal bleeding in a patient with rheumatoid arthritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Colonic Diseases; Female; Gast | 2005 |
Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Blood Vessels; Carmine; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cy | 2006 |
Synthesis of beta-hydroxypropanoic acid derivatives as potential anti-inflammatory, analgesic and antimicrobial agents.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Aspergillus | 2006 |
Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Progression; Electrophoresis, Polyacrylamide Ge | 2006 |
Role of bile in pathogenesis of indomethacin-induced enteropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Bile Acids and Salts; Bile Ducts; Feces; Ind | 2007 |
Tacrolimus (FK506), an immunosuppressive agent, prevents indomethacin-induced small intestinal ulceration in the rat: inhibition of inducible nitric oxide synthase expression.
Topics: Animals; Immunosuppressive Agents; Indomethacin; Intestinal Diseases; Lipid Peroxidation; Male; NF-k | 2007 |
Phytopreventative effects of Gynostemma pentaphyllum against acute Indomethacin-induced gastrointestinal and renal toxicity in rats.
Topics: Acetylglucosaminidase; Administration, Oral; Animals; Chromatography, Thin Layer; Dose-Response Rela | 2007 |
Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cytokines; Disease Models | 2007 |
Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Capillary Permeability; C | 2007 |
Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodieste | 2008 |
Ulcerative enterocolitis in dogs induced by drugs.
Topics: Animals; Colitis; Dogs; Enteritis; Female; Indomethacin; Intestinal Diseases; Male; Peyer's Patches; | 1980 |
Comparison of the effects of solium salicylate with anti-ulcer agents in preventing indomethacin-induced intestinal ulcer.
Topics: Animals; Anti-Ulcer Agents; Female; Indomethacin; Intestinal Diseases; Intestine, Small; Rats; Sodiu | 1981 |
On the relationship between ulcerogenic and anti-inflammatory properties of indomethacin.
Topics: Animals; Edema; Indomethacin; Intestinal Diseases; Male; Rats; Rats, Inbred Strains; Ulcer | 1983 |
[Hemorrhage of the small intestine caused by indomethacin (Indosmos)?].
Topics: Aged; Arthritis, Rheumatoid; Female; Gastrointestinal Hemorrhage; Humans; Ileal Diseases; Indomethac | 1984 |
Preventive effect of PGI2, 7-oxo-PGI2 and 17-aza-PGF2 alpha derivate on the development of indomethacin-induced intestinal mucosal damage in rats.
Topics: Animals; Dinoprost; Epoprostenol; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Prostaglandi | 1984 |
The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Indomethacin; Intestinal Diseases; | 1984 |
Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat.
Topics: Animals; Drug Combinations; Ethanol; Female; Gastric Mucosa; Indomethacin; Intestinal Diseases; Inte | 1984 |
Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals.
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Female; Gastric Acid; Gastric Mucosa; | 1984 |
[Intestinal ulcers in hemodialysis].
Topics: Adult; Humans; Indomethacin; Intestinal Diseases; Male; Renal Dialysis; Ulcer | 1983 |
Ulceration of the small intestine in a patient with celiac disease.
Topics: Aged; Celiac Disease; Diagnosis, Differential; Duodenal Obstruction; Female; Humans; Indomethacin; J | 1984 |
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Indomethacin; Intestinal Diseases; Male; | 1981 |
[The role of endogenous prostaglandin in drug-induced gastrointestinal lesions--comparison of aspirin and indomethacin (author's transl)].
Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Intestinal Diseases; Intestinal Mucosa | 1981 |
Pharmacology of 4-benzyol-1-indancarboxylic acid (TAI-901) and 4-(4-methylbenzoyl)-1-indancarboxylic acid (TAI-908).
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Female; Gastrointestinal Disease | 1982 |
Esophageal ulceration due to indomethacin.
Topics: Adult; Esophageal Diseases; Humans; Indomethacin; Male; Ulcer | 1982 |
[Effects of indomethacin on rats kept on a normal diet and on a diet without prostaglandin precursors].
Topics: Animals; Dietary Fats; Indomethacin; Intestinal Diseases; Intestines; Prostaglandins; Rats; Ulcer | 1980 |
Oxygen radical scavengers are protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Free Radical Scavengers; In | 1995 |
Indomethacin-induced lesion modifies contractile activity in rat small intestines.
Topics: Acetylcholine; Animals; Carbachol; Electric Stimulation; Gastrointestinal Motility; Ileal Diseases; | 1995 |
Dexamethasone promotes ulcer plugging in experimental enteritis.
Topics: Animals; Dexamethasone; Enteritis; Fibrin; Hematologic Tests; Indomethacin; Intestinal Mucosa; Jejun | 1994 |
Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats.
Topics: Animals; Cecal Diseases; Cecum; Granuloma; Indomethacin; Male; Mycobacterium Infections; Opportunist | 1995 |
Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes.
Topics: Animals; Diet; Food, Formulated; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Leukotriene B | 1994 |
Possible precursor of diaphragm disease in the small intestine.
Topics: Female; Humans; Ileal Diseases; Indomethacin; Intestinal Perforation; Middle Aged; Ulcer | 1993 |
Structural and morphometric analysis of murine small intestine after indomethacin administration.
Topics: Animals; Duodenum; Gastrointestinal Diseases; Ileum; Indomethacin; Intestine, Small; Jejunum; Male; | 1993 |
Early histological features of small intestinal injury induced by indomethacin.
Topics: Animals; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Jejunal Diseases; J | 1993 |
Indomethacin-induced gastrointestinal ulcers in rats: effects of dietary fatty acids and endotoxin.
Topics: Animals; Corn Oil; Dietary Fats, Unsaturated; Endotoxins; Fatty Acids; Gastrointestinal Diseases; In | 1993 |
Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antilymphocyte Serum; Etodolac; Gastric Mucosa; Ga | 1995 |
Intravenous nucleosides and a nucleotide promote healing of small bowel ulcers in experimental enterocolitis.
Topics: Animals; Cell Division; Cytidine; Enterocolitis; Female; Guanosine Monophosphate; Indomethacin; Infu | 1996 |
The beta 3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dioxoles; Dose-Response | 1996 |
Pre-ulcerative villous contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Intestinal Mucosa; Jejunal Diseases; | 1995 |
Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis.
Topics: Animal Feed; Animals; Arginine; Female; Food, Fortified; Ileitis; Indomethacin; Nucleotides; Rats; R | 1997 |
Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing.
Topics: Animals; Arginine; Capsaicin; Citrulline; Dose-Response Relationship, Drug; Endothelium; Gastric Aci | 1997 |
Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine.
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile | 1997 |
Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ileum; Indomethacin; Intestinal Mucosa; Ischemia; | 1997 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dicl | 1998 |
Focal reduction of villous blood flow in early indomethacin enteropathy: a dynamic vascular study in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Indomethacin; Jejunal Diseases; Jejunum; M | 1998 |
Increase in tumor necrosis factor-alpha production linked to the toxicity of indomethacin for the rat small intestine.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Di | 1998 |
Indomethacin and pancreatic enzymes synergistically damage intestine of rats.
Topics: Animals; Catheterization; Colon; Colonic Diseases; Drug Synergism; Endopeptidases; Indomethacin; Int | 1998 |
Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Intestinal Diseases; Intestine, Smal | 1999 |
Copper-indomethacinate associated with zwitterionic phospholipids prevents enteropathy in rats: effect on inducible NO synthase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Copper; Indomethacin; Intestine, Small; Jejunum; L | 1999 |
Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enzyme Inhibitors; Gene Expression Regulation; Gua | 1999 |
Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enterobacteriaceae; Guanidines; Indomethacin; Inte | 1999 |
Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes.
Topics: Animals; Anti-Inflammatory Agents; Chalcone; Female; Indomethacin; Lethal Dose 50; Male; Mice; Napht | 2001 |
Nitric oxide inhibitors ameliorate indomethacin-induced enteropathy in rats.
Topics: Amidines; Animals; Benzylamines; Blotting, Western; Enzyme Inhibitors; Guanidines; Indomethacin; Int | 2001 |
COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2002 |
[Protective activity of zolimidine against 2 different types of experimental ulcers of the intestine].
Topics: Animals; Carrageenan; Drug Evaluation, Preclinical; Guinea Pigs; Indomethacin; Intestinal Diseases; | 1978 |
[Drug-induced esophageal damage. Review and report of a fatal case of indomethacin-induced ulceration].
Topics: Aged; Esophageal Diseases; Female; Gastrointestinal Hemorrhage; Humans; Indomethacin; Ulcer | 1979 |
Resistance of germfree rats to indomethacin-induced intestinal lesions.
Topics: Animals; Escherichia coli; Female; Germ-Free Life; Indomethacin; Intestinal Diseases; Intestines; Ma | 1977 |
Cimetidine does not inhibit indomethacin-induced small bowel ulceration in the rat.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Cimetidine; Guanidines; Indomethacin; Intestinal Diseases; | 1979 |
Indomethacin: relationship between ulcerogenic and anti-inflammatory properties. I. Effects of an intestinal lesion-preventing fat-free diet on anti-edema and anti-granuloma properties of indomethacin in the rat.
Topics: Animals; Body Weight; Dietary Fats; Edema; Fatty Acids, Essential; Granuloma; Indomethacin; Inflamma | 1978 |
[Iatrogenic ulcer of the esophagus].
Topics: Aged; Esophageal Diseases; Humans; Indomethacin; Male; Osteoarthritis; Ulcer | 1978 |
Studies on the mechanism of fat-free diet (FFD) protection against indomethacin-induced intestinal ulcers.
Topics: Animals; Bile; Dietary Fats; Female; Glucaric Acid; Glucuronidase; Indomethacin; Intestinal Diseases | 1978 |
Indomethacin-induced intestinal inflammation.
Topics: Animals; Colchicine; Dexamethasone; DNA; Enteritis; Female; Ileum; Indomethacin; Intestinal Mucosa; | 1977 |
Oral ulcerations associated with indomethacin therapy: report of three cases.
Topics: Aged; Female; Humans; Indomethacin; Male; Middle Aged; Mouth Diseases; Mouth Mucosa; Ulcer | 1975 |
Gastrointestinal effects and acute toxicity of suprofen.
Topics: Animals; Antidiarrheals; Aspirin; Digestive System; Dogs; Dose-Response Relationship, Drug; Drug Eva | 1975 |
L-dopa is protective against indomethacin-induced small intestinal ulceration in the rat: possible role of an alpha-2-adrenergic mechanism.
Topics: Animals; Clonidine; Haloperidol; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Levodopa; Mal | 1992 |
A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats.
Topics: Animals; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Germ-Free Life; Ibuprofen; Indomethaci | 1992 |
Microcirculatory disturbance in indomethacin-induced intestinal ulcer.
Topics: Animals; Benzoquinones; Chromones; Fluorescein-5-isothiocyanate; Fluoresceins; Indomethacin; Intesti | 1991 |
[A study on the mechanism of indomethacin induced intestinal ulcer--from a viewpoint of unstirred water layer].
Topics: Animals; Body Water; Glycoproteins; Indomethacin; Intestinal Diseases; Intestine, Small; Male; Rats; | 1991 |
Modulation by opiates of small intestinal prostaglandin E2 and 3',5'cyclic adenosine monophosphate levels and of indomethacin-induced ulceration in the rat.
Topics: Animals; Cyclic AMP; Dinoprostone; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Morphine | 1991 |
Indomethacin-induced intestinal ulcers in rats: effects of salicylazosulfapyridine and dexamethasone.
Topics: Animals; Dexamethasone; Female; Indomethacin; Inflammation; Intestinal Diseases; Rats; Sulfasalazine | 1985 |
Antiulcerogenic and antisecretory effects of a novel diphenylmethane derivative and antiestrogen binding site ligand.
Topics: Animals; Bethanechol; Bethanechol Compounds; Corticosterone; Gastric Acid; Indomethacin; Male; Pheny | 1988 |
The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats.
Topics: Animals; Anti-Ulcer Agents; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Female; Gastri | 1988 |
Naloxone is protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Animals; Cimetidine; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Intes | 1985 |
[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidoni | 1986 |
Mucosal lesions induced in the rat intestinal tract by the anti-inflammatory drug, Wy-41,770, a weak inhibitor of prostaglandin synthesis, contrasted with those from the potent prostaglandin inhibitor, indomethacin.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Cyclooxygenase Inhibitors; Dib | 1988 |
Sucralfate is protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Animals; Dinoprostone; Indomethacin; Injections, Subcutaneous; Intestinal Mucosa; Intubation, Gastro | 1988 |
Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Administration, Oral; Animals; Biological Availability; Freeze F | 1988 |
1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks' daily administration of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Indomethacin; Intestinal Diseas | 1987 |
Quantitative analysis of intestinal ulceration induced by indomethacin, in rats.
Topics: Animals; Female; Indomethacin; Intestinal Diseases; Intestine, Small; Rats; Rats, Inbred Strains; Te | 1987 |
Diphenyldisulfide inhibits indomethacin-induced ulcerogenesis in rats.
Topics: Animals; Disulfides; Indomethacin; Intestinal Diseases; Lipoxygenase Inhibitors; Male; Rats; Ulcer | 1987 |
Indomethacin fails to induce ulceration in the gastrointestinal tract of newborn and suckling rats.
Topics: Animals; Animals, Newborn; Indomethacin; Intestinal Diseases; Prostaglandins; Rats; Rats, Inbred Str | 1986 |
Involvement of capsaicin-sensitive mechanism(s) in the antiulcer defence of intestinal mucosa in rats.
Topics: Animals; Capsaicin; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Male; Rats; Rats, Inbred S | 1987 |
Osmosin and ileal ulceration: a case report.
Topics: Aged; Delayed-Action Preparations; Female; Humans; Ileal Diseases; Indomethacin; Ulcer | 1985 |
Indomethacin reaction.
Topics: Adult; Humans; Indomethacin; Male; Mouth Diseases; Pharyngeal Diseases; Ulcer | 1985 |
Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat.
Topics: Animals; Dietary Fats; Indomethacin; Intestinal Diseases; Intestines; Male; Rats; Rats, Inbred Strai | 1985 |
Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Eating; Female; Indomethacin; Intestinal Disease | 1985 |
What's new in Osmosin and intestinal perforation?
Topics: Aged; Humans; Ileal Diseases; Ileum; Indomethacin; Intestinal Perforation; Ulcer | 1985 |
Jejunal ulcers produced by indomethacin.
Topics: Animals; Female; Indomethacin; Intestinal Diseases; Jejunum; Rats; Ulcer | 1969 |
Prevention of indomethacin-induced intestinal ulcers by various catatoxic steroids.
Topics: Adrenal Cortex Hormones; Animals; Antitoxins; Chemical Phenomena; Chemistry; Corticosterone; Ethyles | 1970 |
Ulceration and stricture of the jejunum in a patient on long-term indomethacin therapy.
Topics: Humans; Indomethacin; Intestinal Obstruction; Jejunum; Male; Middle Aged; Radiography; Spondylitis, | 1973 |
Indomethacin in the treatment of pericarditis in patients on chronic hemodialysis.
Topics: Adolescent; Adult; Aerobiosis; Anaerobiosis; Bacteria; Duodenum; Female; Fungi; Humans; Indomethacin | 1973 |
Factors influencing the development of indomethacin-induced intestinal ulcers in the rat.
Topics: 1-Propanol; Animals; Cholagogues and Choleretics; Dietary Fats; Female; Indomethacin; Intestinal Dis | 1974 |
[Toxicologic study of methiazinic acid (16091 R.P)].
Topics: Abnormalities, Drug-Induced; Acetates; Anemia; Animals; Dogs; Drug Tolerance; Female; Gastric Mucosa | 1969 |
Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.
Topics: Animals; Digitoxin; Drug Antagonism; Female; Indomethacin; Intestinal Diseases; Jejunum; Microsomes, | 1971 |
Small intestinal ulcers and intestinal flora in rats given indomethacin.
Topics: Animals; Anti-Bacterial Agents; Cecal Diseases; Ileum; Indomethacin; Intestinal Diseases; Intestine, | 1969 |
Drug induced ulceration and perforation of the small intestine.
Topics: Adult; Humans; Indomethacin; Intestinal Perforation; Intestine, Small; Male; Middle Aged; Ulcer | 1966 |