indomethacin has been researched along with Trypanosomiasis, African in 6 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the first stage of human African trypanosomiasis (HAT), Trypanosoma brucei gambiense is found mainly in the blood, and pentamidine treatment is used." | 1.35 | Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. ( De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA, 2009) |
| "The indomethacin-treated co-cultures, which manifest a normal IL 2 production but lack the IL 2 receptors, manifest an impaired DNA synthesis and contain a decreased number of T cell blasts." | 1.28 | Different mechanisms account for the suppression of interleukin 2 production and the suppression of interleukin 2 receptor expression in Trypanosoma brucei-infected mice. ( Darji, A; De Baetselier, P; Hamers, R; Remels, L; Sileghem, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanderson, L | 1 |
| Dogruel, M | 1 |
| Rodgers, J | 1 |
| De Koning, HP | 1 |
| Thomas, SA | 1 |
| Fierer, J | 1 |
| Salmon, JA | 1 |
| Askonas, BA | 1 |
| Wellhausen, SR | 1 |
| Mansfield, JM | 2 |
| Schleifer, KW | 1 |
| Sileghem, M | 1 |
| Darji, A | 1 |
| Remels, L | 1 |
| Hamers, R | 1 |
| De Baetselier, P | 1 |
| Reed, SL | 1 |
| Fierer, AS | 1 |
| Goddard, DR | 1 |
| Colmerauer, ME | 1 |
| Davis, CE | 1 |
6 other studies available for indomethacin and Trypanosomiasis, African
| Article | Year |
|---|---|
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Bl | 2009 |
African trypanosomiasis alters prostaglandin production by murine peritoneal macrophages.
Topics: Animals; Cell Adhesion; Dinoprostone; Epoprostenol; Female; Immune Tolerance; Indomethacin; Lipopoly | 1984 |
Characteristics of the splenic suppressor cell--target cell interaction in experimental African trypanosomiasis.
Topics: Animals; Cell Adhesion; Cell Communication; Cell Survival; Cell-Free System; Immunosuppression Thera | 1980 |
Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins.
Topics: Animals; Arginine; Female; Immune Tolerance; Indomethacin; Interferon-gamma; Lymphocyte Activation; | 1993 |
Different mechanisms account for the suppression of interleukin 2 production and the suppression of interleukin 2 receptor expression in Trypanosoma brucei-infected mice.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Antigens, Ly; Binding, Competitive; Cells, Culture | 1989 |
Effect of theophylline on differentiation of Trypanosoma brucei.
Topics: Aminophylline; Animals; Cell Differentiation; Cyclic AMP; Female; Indomethacin; Prostaglandins; Rats | 1985 |