indomethacin has been researched along with Thrombopenia in 26 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) infants is routinely treated in many countries with oral ibuprofen." | 8.02 | Oral ibuprofen promoted cholestatic liver disease in very low birth weight infants with patent ductus arteriosus. ( Guo, H; Huang, Y; Lin, HC; Liu, H; Peng, H; Shen, X; Yao, S; Zhou, M; Zhou, P, 2021) |
| "A case of acute thrombocytopenia with shortened platelet survival following ingestion of indomethacin is reported." | 7.67 | Acute thrombocytopenia following ingestion of indomethacin. ( Camba, L; Joyner, MV, 1984) |
| "Hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) infants is routinely treated in many countries with oral ibuprofen." | 4.02 | Oral ibuprofen promoted cholestatic liver disease in very low birth weight infants with patent ductus arteriosus. ( Guo, H; Huang, Y; Lin, HC; Liu, H; Peng, H; Shen, X; Yao, S; Zhou, M; Zhou, P, 2021) |
| " Pretreatment of the animals with indomethacin and econazol at doses that significantly decreased thromboxane levels in the synovial fluids reduced the arthritis-related thrombocytopenia in the acute phase of arthritis." | 3.68 | Mechanisms of thrombocytopenia in the acute phase of antigen-induced arthritis in rabbits. ( Calvo, IF; da Rocha, FA; de Falco, V; Fernandes, AJ; Jancar, S; Sirois, P, 1991) |
| "A case of acute thrombocytopenia with shortened platelet survival following ingestion of indomethacin is reported." | 3.67 | Acute thrombocytopenia following ingestion of indomethacin. ( Camba, L; Joyner, MV, 1984) |
| " The sensitivity of the bleeding time to the presence of antibiotics, indomethacin, generalized illness, and thrombocytopenia was tested in 242 infants." | 3.67 | Modified bleeding time in the infant. ( Andrew, M; Castle, V; Mitchell, L; Paes, B, 1989) |
| " Parameters measured were hemoconcentration (monitored by changes in hematocrit), thrombocytopenia (platelet counts), leukopenia (loss of buffy coat), bronchoconstriction (increased airway resistance to fixed airway ventilation), thromboxane A2 production (radioimmunoassay to thromboxane B2) and in vitro aggregation responses of platelets in platelet-rich plasma." | 3.67 | Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. ( Handley, DA; Saunders, RN; Van Valen, RG, 1986) |
| " In normal animals the administration of indomethacin and sodium salicylate cause similar effects to thrombocytopenia whereas the injection of human plasma fraction affects only the leucocyte migration." | 3.65 | Platelets, prostaglandins and inflammation. ( Ford-Hutchinson, AW; Penington, DG; Smith, MJ; Walker, JR, 1976) |
| "Hypotension was presumably caused by two factors: an early decrease in systemic vascular resistance and the large reduction in cardiac output due to reduced ventricular filling." | 1.29 | Haemodynamic and haematologic effects of Acanthaster planci venom in dogs. ( Hirayama, K; Matsuzaki, T; Noguchi, K; Ojiri, Y; Sakanashi, M; Shiroma, N, 1994) |
| "However, thrombocytopenia was not reversed by IDM." | 1.28 | The involvement of platelet-activating factor in thrombocytopenia and follicular rupture during gonadotropin-induced superovulation in immature rats. ( Ban, C; Hasegawa, M; Ihara, Y; Inamori, K; Itoh, H; Li, XM; Mori, T; Okagaki, A; Sagawa, N, 1991) |
| "025-16 micrograms/paw) were followed by a bell-shaped dose-response curve for oedema." | 1.27 | Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat. ( Castro, HC; Cordeiro, RS; Lima, MC; Martins, MA; Neto, F; Silva, PM; Vargaftig, BB, 1987) |
| " An overestimation of rare side-effects of drugs should not block the application of certain medicaments, however, they should be given only in such a high dosage as it is necessary." | 1.26 | [Hematotoxic lesions caused by non-steroidal antirheumatic agents]. ( Hüge, W; Stobbe, H, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (69.23) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, X | 1 |
| Huang, Y | 1 |
| Guo, H | 1 |
| Peng, H | 1 |
| Yao, S | 1 |
| Zhou, M | 1 |
| Liu, H | 1 |
| Lin, HC | 1 |
| Zhou, P | 1 |
| Tofé Valera, I | 1 |
| Jaraba Caballero, MP | 1 |
| Ruiz González, MD | 1 |
| Rodríguez Benítez, MV | 1 |
| Parraga Quiles, MJ | 1 |
| Sallmon, H | 1 |
| Weber, SC | 1 |
| Hüning, B | 1 |
| Stein, A | 1 |
| Horn, PA | 1 |
| Metze, BC | 1 |
| Dame, C | 1 |
| Bührer, C | 1 |
| Felderhoff-Müser, U | 1 |
| Hansmann, G | 1 |
| Koehne, P | 1 |
| Little, DC | 1 |
| Pratt, TC | 1 |
| Blalock, SE | 1 |
| Krauss, DR | 1 |
| Cooney, DR | 1 |
| Custer, MD | 1 |
| Rickles, FR | 1 |
| Edwards, RL | 1 |
| Camba, L | 1 |
| Joyner, MV | 1 |
| Maguire, ED | 1 |
| Wallis, RB | 1 |
| Butler, RR | 1 |
| Wise, WC | 1 |
| Halushka, PV | 1 |
| Cook, JA | 1 |
| Berliner, S | 1 |
| Sidi, Y | 1 |
| Shaklai, M | 1 |
| Pinkhas, J | 1 |
| Chong, BH | 1 |
| Grace, CS | 1 |
| Rozenberg, MC | 1 |
| Stobbe, H | 1 |
| Hüge, W | 1 |
| Shiroma, N | 1 |
| Noguchi, K | 1 |
| Matsuzaki, T | 1 |
| Ojiri, Y | 1 |
| Hirayama, K | 1 |
| Sakanashi, M | 1 |
| Olson, NC | 1 |
| Kruse-Elliott, KT | 1 |
| Whorton, AR | 1 |
| Dodam, JR | 1 |
| Menzel, K | 1 |
| Schambach, K | 1 |
| Töpke, B | 1 |
| Blajchman, MA | 1 |
| Senyi, AF | 1 |
| Hirsh, J | 1 |
| Surya, Y | 1 |
| Buchanan, M | 1 |
| Mustard, JF | 1 |
| Chignard, M | 1 |
| Lefort, J | 1 |
| Vargaftig, BB | 2 |
| Tolot, F | 1 |
| Prost, G | 1 |
| Guignot, B | 1 |
| Pelletier, M | 1 |
| Smith, MJ | 1 |
| Walker, JR | 1 |
| Ford-Hutchinson, AW | 1 |
| Penington, DG | 1 |
| Ubatuba, FB | 1 |
| Harvey, EA | 1 |
| Ferreira, SH | 1 |
| Fernandes, AJ | 1 |
| Calvo, IF | 1 |
| de Falco, V | 1 |
| da Rocha, FA | 1 |
| Sirois, P | 1 |
| Jancar, S | 1 |
| Li, XM | 1 |
| Sagawa, N | 1 |
| Ihara, Y | 1 |
| Okagaki, A | 1 |
| Hasegawa, M | 1 |
| Inamori, K | 1 |
| Itoh, H | 1 |
| Mori, T | 1 |
| Ban, C | 1 |
| Müller, B | 1 |
| Schmidtke, M | 1 |
| Witt, W | 1 |
| Andrew, M | 1 |
| Castle, V | 1 |
| Mitchell, L | 1 |
| Paes, B | 1 |
| Martins, MA | 1 |
| Silva, PM | 1 |
| Castro, HC | 1 |
| Neto, F | 1 |
| Lima, MC | 1 |
| Cordeiro, RS | 1 |
| Handley, DA | 1 |
| Van Valen, RG | 1 |
| Saunders, RN | 1 |
| Treske, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for indomethacin and Thrombopenia
| Article | Year |
|---|---|
Patent ductus arteriosus in micropreemies and full-term infants: the relative merits of surgical ligation versus indomethacin treatment.
Topics: Ductus Arteriosus, Patent; Female; Gestational Age; Hemorrhage; Humans; Indomethacin; Infant, Newbor | 2003 |
[The patent ductus arteriosus from a perinatological viewpoint].
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Fetus; Gastrointestinal Hemorrhage; Growth; Hu | 1978 |
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone].
Topics: Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Tolera | 1976 |
23 other studies available for indomethacin and Thrombopenia
| Article | Year |
|---|---|
Oral ibuprofen promoted cholestatic liver disease in very low birth weight infants with patent ductus arteriosus.
Topics: Birth Weight; Cholestasis; Ductus Arteriosus, Patent; Emulsions; Humans; Ibuprofen; Indomethacin; In | 2021 |
The Role of Paracetamol for Closing Patent Ductus Arteriosus. A Challenging Alternative for Ductal Closure?
Topics: Acetaminophen; Administration, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorr | 2016 |
Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus.
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Echocardiography, Doppler; Female; Humans; Ibu | 2012 |
Activation of blood coagulation in cancer: Trousseau's syndrome revisited.
Topics: Antibodies; Aspirin; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Platelets; Cell A | 1983 |
Acute thrombocytopenia following ingestion of indomethacin.
Topics: Acute Disease; Aged; Female; Humans; Indomethacin; Platelet Count; Thrombocytopenia | 1984 |
In vivo redirection of prostaglandin endoperoxides into 6-keto PGF1 alpha formation by thromboxane synthetase inhibitors in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Platelets; Collagen; Imidazoles; Indoles; Indomethacin; | 1983 |
Thromboxane and prostacyclin production during septic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Epoprostenol; Fatty Acids, Essential; Female; Fibrin Fibrinog | 1982 |
Appearance of thrombocytopenia and benign monoclonal gammopathy following intake of drugs.
Topics: Aged; Ampicillin; Aspirin; Dipyrone; Female; Humans; Hypergammaglobulinemia; Indomethacin; Male; Mid | 1982 |
Heparin-induced thrombocytopenia: effect of heparin platelet antibody on platelets.
Topics: Adenosine Diphosphate; Adult; Antibodies; Aspirin; Blood Platelets; Complement Fixation Tests; Dipyr | 1981 |
[Hematotoxic lesions caused by non-steroidal antirheumatic agents].
Topics: Adult; Aged; Agranulocytosis; Anemia, Aplastic; Arthritis, Rheumatoid; Aspirin; Diclofenac; Female; | 1980 |
Haemodynamic and haematologic effects of Acanthaster planci venom in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Cells; Blood Pressure; Cardiac Output; Cyclooxygenase I | 1994 |
Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs.
Topics: Animals; Blood Platelets; Calcimycin; GTP-Binding Proteins; Hemodynamics; Indomethacin; Injections, | 1993 |
Shortening of the bleeding time in rabbits by hydrocortisone caused by inhibition of prostacyclin generation by the vessel wall.
Topics: Animals; Arachidonic Acids; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Capillaries | 1979 |
Platelet effects of arachidonic acid in dog blood. I. Lack of involvement of cyclo-oxygenase in the in vivo situation.
Topics: Adenosine Diphosphate; Ancrod; Animals; Arachidonic Acids; Aspirin; Blood Platelets; Dogs; Dose-Resp | 1977 |
Platelets, prostaglandins and inflammation.
Topics: Animals; Blood Cell Count; Blood Platelets; Exudates and Transudates; Female; Immune Sera; Indometha | 1976 |
Are platelets important in inflammation?
Topics: Animals; Blood Platelets; Carrageenan; Edema; Female; Immune Sera; Indomethacin; Inflammation; Passi | 1975 |
Mechanisms of thrombocytopenia in the acute phase of antigen-induced arthritis in rabbits.
Topics: Animals; Arthritis, Experimental; Diterpenes; Econazole; Female; Ginkgolides; Indoles; Indomethacin; | 1991 |
The involvement of platelet-activating factor in thrombocytopenia and follicular rupture during gonadotropin-induced superovulation in immature rats.
Topics: Animals; Azepines; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Indomethacin; Ovulation; O | 1991 |
Adherence of leucocytes to electrically damaged venules in vivo. Effects of iloprost, PGE1, indomethacin, forskolin, BW 755 C, sulotroban, hirudin, and thrombocytopenia.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alprostadil; Animals; Cell Adhesion; C | 1988 |
Modified bleeding time in the infant.
Topics: Anti-Bacterial Agents; Bleeding Time; Humans; Indomethacin; Infant, Newborn; Platelet Count; Platele | 1989 |
Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Edema; Indomethacin; Inflammation; Male; | 1987 |
Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119.
Topics: Animals; Cebus; Indomethacin; Lung; Macaca mulatta; Male; Papio; Platelet Activating Factor; Platele | 1986 |
[Indomethacin and hematopoiesis. Antipyretic and antiphlogistic effects in hemoblastoses and various uncommon diseases].
Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Dermatomyositis; Female; Hematologic Diseases; Hematop | 1968 |