Page last updated: 2024-10-29

indomethacin and Sunburn

indomethacin has been researched along with Sunburn in 18 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Sunburn: An injury to the skin causing erythema, tenderness, and sometimes blistering and resulting from excessive exposure to the sun. The reaction is produced by the ultraviolet radiation in sunlight.

Research Excerpts

ExcerptRelevanceReference
" In this study we evaluated an assumptive anti-inflammatory effect of the nonsedative histamine H1-receptor antagonist, mizolastine, on UV-induced acute sunburn reaction."9.09UV erythema reducing capacity of mizolastine compared to acetylsalicylic acid or both combined in comparison to indomethacin. ( Böckelmann, R; Bonnekoh, B; Gollnick, HP; Grundmann, JU, 2001)
"The inhibitory effects of topical indomethacin (IM)-treatment on sunburn and suntan reactions after ultraviolet (UV)-irradiation were investigated in the dorsal skin of hairless descendants of Mexican hairless dogs."7.70Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs. ( Doi, K; Kimura, T, 1998)
"The extent to which topical and intradermal corticosteroids and topical indomethacin suppress sunburn erythema was investigated in human volunteers."7.65The influence of corticosteroids and topical indomethacin on sunburn erythema. ( Kaidbey, KH; Kurban, AK, 1976)
" In this study we evaluated an assumptive anti-inflammatory effect of the nonsedative histamine H1-receptor antagonist, mizolastine, on UV-induced acute sunburn reaction."5.09UV erythema reducing capacity of mizolastine compared to acetylsalicylic acid or both combined in comparison to indomethacin. ( Böckelmann, R; Bonnekoh, B; Gollnick, HP; Grundmann, JU, 2001)
"The inhibitory effects of topical indomethacin (IM)-treatment on sunburn and suntan reactions after ultraviolet (UV)-irradiation were investigated in the dorsal skin of hairless descendants of Mexican hairless dogs."3.70Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs. ( Doi, K; Kimura, T, 1998)
"5 per cent indomethacin (IM) solution to the sunburned skin of humans and guinea pigs resulted in a marked decrease in ultraviolet light (UVL) -induced erythema."3.65Cutaneous effects of topical indomethacin, an inhibitor of prostaglandin synthesis, on UV-damaged skin. ( Snyder, DS, 1975)
"The extent to which topical and intradermal corticosteroids and topical indomethacin suppress sunburn erythema was investigated in human volunteers."3.65The influence of corticosteroids and topical indomethacin on sunburn erythema. ( Kaidbey, KH; Kurban, AK, 1976)
" A skin biopsy was taken at 24 h after each dosing with UVB."2.67Synergistic effects of oral nonsteroidal drugs and topical corticosteroids in the therapy of sunburn in humans. ( Bohan, DF; Caruana, C; Francom, SF; Holland, M; Hughes, GS; Means, LK, 1992)
"Treatment with indomethacin, an inhibitor of prostaglandin (PG) synthesis, inhibited UV-induced inflammation and abrogated immunosuppression."1.31Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice. ( Horiki, S; Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Okamoto, H; Tanaka, K, 2001)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199012 (66.67)18.7374
1990's2 (11.11)18.2507
2000's2 (11.11)29.6817
2010's2 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pilkington, SM1
Murphy, SA1
Kudva, S1
Nicolaou, A1
Rhodes, LE1
Nakamura, M1
Haarmann-Stemmann, T1
Krutmann, J1
Lim, HW1
Thorbecke, GJ1
Baer, RL1
Gigli, I1
Sloan, KB1
Selk, S1
Haslam, J1
Caldwell, L1
Shaffer, R1
Gschnait, F2
Schwarz, T1
Seiser, A1
Kimura, T1
Doi, K1
Grundmann, JU1
Böckelmann, R1
Bonnekoh, B1
Gollnick, HP1
Horio, T1
Miyauchi-Hashimoto, H1
Kuwamoto, K1
Horiki, S1
Okamoto, H1
Tanaka, K1
Peters, P1
Cooper, C1
Maiorana, K1
Graeme, ML1
Holý, B1
Faberová, J1
Pehamberger, H1
Weirich, EG1
Lutz, UC1
Snyder, DS3
Eaglstein, WH2
Kaidbey, KH1
Kurban, AK1
Hughes, GS1
Francom, SF1
Means, LK1
Bohan, DF1
Caruana, C1
Holland, M1

Trials

3 trials available for indomethacin and Sunburn

ArticleYear
UV erythema reducing capacity of mizolastine compared to acetylsalicylic acid or both combined in comparison to indomethacin.
    Photochemistry and photobiology, 2001, Volume: 74, Issue:4

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzimidazoles; Cells, Cultured

2001
Synergistic effects of oral nonsteroidal drugs and topical corticosteroids in the therapy of sunburn in humans.
    Dermatology (Basel, Switzerland), 1992, Volume: 184, Issue:1

    Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Betameth

1992
Topical indomethacin and sunburn.
    The British journal of dermatology, 1974, Volume: 90, Issue:1

    Topics: Acetates; Administration, Topical; Adult; Anti-Inflammatory Agents; Evaluation Studies as Topic; Flu

1974

Other Studies

15 other studies available for indomethacin and Sunburn

ArticleYear
COX inhibition reduces vasodilator PGE2 but is shown to increase levels of chemoattractant 12-HETE in vivo in human sunburn.
    Experimental dermatology, 2015, Volume: 24, Issue:10

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Cyclooxygenase Inhibitors; Dinoprostone; Female;

2015
COX inhibition enhances inflammatory immune cell infiltration in UV-irradiated human skin: implications for the treatment of sunburn.
    Experimental dermatology, 2015, Volume: 24, Issue:10

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans;

2015
Effect of indomethacin on alteration of ATPase-positive Langerhans cell density and cutaneous sunburn reaction induced by ultraviolet-B radiation.
    The Journal of investigative dermatology, 1983, Volume: 81, Issue:5

    Topics: 4-Aminobenzoic Acid; Adenosine Triphosphatases; Administration, Topical; Animals; Guinea Pigs; Indom

1983
Acyloxyamines as prodrugs of anti-inflammatory carboxylic acids for improved delivery through skin.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:12

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Burns; Carboxylic Acids; Chemical Phenom

1984
Topical indomethacin protects from UVB and UVA irradiation.
    Archives of dermatological research, 1984, Volume: 276, Issue:2

    Topics: Administration, Topical; Dose-Response Relationship, Radiation; Humans; Indomethacin; Sunburn; Ultra

1984
Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs.
    Histology and histopathology, 1998, Volume: 13, Issue:1

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dogs; Femal

1998
Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice.
    The journal of investigative dermatology. Symposium proceedings, 2001, Volume: 6, Issue:1

    Topics: Animals; Apyrase; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dermatit

2001
The effect of topically applied agents on ultraviolet erythema in guinea pigs.
    Agents and actions, 1977, Volume: 7, Issue:5-6

    Topics: 4-Aminobenzoic Acid; Administration, Topical; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhi

1977
[Antiphlogistic effect of indomethacin in local therapy (author's transl)].
    Ceskoslovenska dermatologie, 1978, Volume: 53, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Betamethasone Valerate; Humans; Indomethacin; Phenylbutazone; Skin;

1978
Indomethacin does not affect PUVA induced erythema.
    Archives for dermatological research = Archiv fur dermatologische Forschung, 1977, Jul-21, Volume: 259, Issue:1

    Topics: Adult; Humans; Indomethacin; Methoxsalen; Sunburn; Ultraviolet Rays

1977
[Inhibition of ultraviolet irradiation response of human skin by topical phlogostatic compounds (author's transl)].
    Archives for dermatological research = Archiv fur dermatologische Forschung, 1977, Jul-21, Volume: 259, Issue:1

    Topics: Bufexamac; Flumethasone; Fluocinolone Acetonide; Humans; Hydrocortisone; Indomethacin; Oxyphenbutazo

1977
Effect of topical indomethacin on UVR-induced redness and prostaglandin E levels in sunburned guinea pig skin.
    Prostaglandins, 1976, Volume: 11, Issue:4

    Topics: Administration, Topical; Animals; Female; Guinea Pigs; Indomethacin; Prostaglandins E; Radiation Inj

1976
Cutaneous effects of topical indomethacin, an inhibitor of prostaglandin synthesis, on UV-damaged skin.
    The Journal of investigative dermatology, 1975, Volume: 64, Issue:5

    Topics: Administration, Topical; Animals; Cell Survival; Depression, Chemical; DNA; Erythema; Female; Guinea

1975
Indomethacin: treatment for sunburn or investigative tool in ultraviolet inflammation?
    International journal of dermatology, 1975, Volume: 14, Issue:7

    Topics: Indomethacin; Sunburn; Ultraviolet Rays

1975
The influence of corticosteroids and topical indomethacin on sunburn erythema.
    The Journal of investigative dermatology, 1976, Volume: 66, Issue:3

    Topics: Administration, Topical; Adult; Betamethasone; Betamethasone Valerate; Humans; Indomethacin; Injecti

1976