indomethacin has been researched along with Subarachnoid Hemorrhage in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We designed the present experiments to investigate the involvement of endogenous nitric oxide synthase (NOS) inhibitors, dimethylarginine dimethylaminohydrolase (DDAH) as a hydrolyzing enzyme of the NOS inhibitors, NOS, arginase which shares l-arginine as a common substrate with NOS, and endothelin-1 (ET-1) in the pulmonary dysfunction after induction of experimental subarachnoid hemorrhage (SAH) in the rabbit." | 7.74 | Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit. ( Azuma, H; Imamura, M; Isotani, E; Mizuno, Y; Nagai, A; Ohno, K, 2008) |
| "We designed the present experiments to investigate the involvement of endogenous nitric oxide synthase (NOS) inhibitors, dimethylarginine dimethylaminohydrolase (DDAH) as a hydrolyzing enzyme of the NOS inhibitors, NOS, arginase which shares l-arginine as a common substrate with NOS, and endothelin-1 (ET-1) in the pulmonary dysfunction after induction of experimental subarachnoid hemorrhage (SAH) in the rabbit." | 3.74 | Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit. ( Azuma, H; Imamura, M; Isotani, E; Mizuno, Y; Nagai, A; Ohno, K, 2008) |
| "The effect of indomethacin, a cyclooxygenase inhibitor, was studied in the treatment of 10 patients with head injury and one patient with spontaneous subarachnoid hemorrhage, each of whom presented with high intracranial pressure (ICP) (34." | 3.69 | Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report. ( Alberti, RA; Biestro, AA; Borovich, B; Cancela, M; Puppo, CB; Soca, AE, 1995) |
| "In small human cerebral arteries preincubated with indomethacin, contractions induced by cerebrospinal fluid (CSF), from patients with subarachnoid hemorrhage were markedly increased." | 3.66 | Effects of indomethacin and prostacyclin on isolated human pial arteries contracted by CSF from patients with aneurysmal SAH. ( Andersson, KE; Brandt, L; Hindfelt, B; Ljunggren, B; Uski, T, 1981) |
| "The subarachnoid hemorrhage was induced by injecting arterial blood in the cisterna magna." | 1.28 | Effects of subarachnoid hemorrhage on platelet-derived vasoconstriction of rabbit basilar artery. ( Kassell, NF; Tanaka, Y; Torner, JC, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halker, RB | 1 |
| Vargas, BB | 1 |
| Mizuno, Y | 1 |
| Isotani, E | 1 |
| Ohno, K | 1 |
| Nagai, A | 1 |
| Imamura, M | 1 |
| Azuma, H | 1 |
| Walker, V | 2 |
| Pickard, JD | 2 |
| Smythe, P | 1 |
| Eastwood, S | 2 |
| Perry, S | 2 |
| Smythe, PJ | 1 |
| Hunt, R | 1 |
| Brandt, L | 1 |
| Ljunggren, B | 1 |
| Andersson, KE | 1 |
| Hindfelt, B | 1 |
| Uski, T | 1 |
| Biestro, AA | 1 |
| Alberti, RA | 1 |
| Soca, AE | 1 |
| Cancela, M | 1 |
| Puppo, CB | 1 |
| Borovich, B | 1 |
| Yakubu, MA | 1 |
| Leffler, CW | 1 |
| Tran Dinh, YR | 1 |
| Roche, S | 1 |
| Debdi, M | 1 |
| Seylaz, J | 1 |
| Sercombe, R | 1 |
| Simpson, RK | 1 |
| Fischer, DK | 1 |
| Ehni, BL | 1 |
| Tanaka, Y | 1 |
| Kassell, NF | 1 |
| Torner, JC | 1 |
| Sicuteri, F | 1 |
| Fanciullacci, M | 1 |
| Bavazzano, A | 1 |
| Franchi, G | 1 |
| Del Bianco, PL | 1 |
1 review available for indomethacin and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Primary exertional headache: updates in the literature.
Topics: Comorbidity; Diagnosis, Differential; Female; Headache Disorders, Primary; Humans; Indomethacin; Mal | 2013 |
10 other studies available for indomethacin and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit.
Topics: Acetylcholine; Amidohydrolases; Animals; Arginase; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Respo | 2008 |
Effects of subarachnoid haemorrhage on intracranial prostaglandins.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Platelets; Cerebral Arteries; Cerebral Cortex; Choroid | 1983 |
Arterial eicosanoid production following chronic exposure to a periarterial haematoma.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Carotid Arteries; Carotid Artery Diseases; Dinoprost; Dinopro | 1984 |
Effects of indomethacin and prostacyclin on isolated human pial arteries contracted by CSF from patients with aneurysmal SAH.
Topics: Adult; Aged; Alprostadil; Arachidonic Acid; Arachidonic Acids; Arteries; Epoprostenol; Female; Human | 1981 |
Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report.
Topics: Adolescent; Adult; Blood Pressure; Body Temperature; Brain Injuries; Carbon Dioxide; Cerebrovascular | 1995 |
5-Hydroxytryptamine-induced vasoconstriction after cerebral hematoma in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Dose-Response Relationship, Drug; Drug Evaluation, Preclinica | 1997 |
Effects of oxyhemoglobin in vitro in cerebral arteries from normal animals and animals subject to subarachnoid hemorrhage or indomethacin treatment.
Topics: Acetylcholine; Animals; Basilar Artery; Cyclooxygenase Inhibitors; Histamine; In Vitro Techniques; I | 1998 |
Neurogenic hyperthermia in subarachnoid hemorrhage.
Topics: Adult; Combined Modality Therapy; Cyproheptadine; Fever; Humans; Indomethacin; Ischemic Attack, Tran | 1989 |
Effects of subarachnoid hemorrhage on platelet-derived vasoconstriction of rabbit basilar artery.
Topics: Animals; Basilar Artery; Blood Platelets; Imidazoles; Indomethacin; Isometric Contraction; Ketanseri | 1989 |
Kinins and intracranial hemorrhages.
Topics: Animals; Brain; Capillaries; Cerebral Hemorrhage; Escape Reaction; Humans; Indomethacin; Injections, | 1970 |