indomethacin has been researched along with Stroke in 8 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the effects of a novel pharmacological brain cooling (PBC) method with indomethacin (IND), a nonselective cyclooxygenase inhibitor, without the use of cooling blankets in patients with hemorrhagic stroke." | 9.12 | Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects. ( Abe, T; Aruga, T; Dohi, K; Fujita, S; Ikeda, Y; Jimbo, H; Ohtaki, H; Shioda, S, 2006) |
| "We evaluated the effects of a novel pharmacological brain cooling (PBC) method with indomethacin (IND), a nonselective cyclooxygenase inhibitor, without the use of cooling blankets in patients with hemorrhagic stroke." | 5.12 | Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects. ( Abe, T; Aruga, T; Dohi, K; Fujita, S; Ikeda, Y; Jimbo, H; Ohtaki, H; Shioda, S, 2006) |
| "Overall, the use of NSAIDs is not associated with an increased risk of hemorrhagic stroke, although this risk was modestly significantly elevated in diclofenac and meloxicam users." | 4.93 | Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies. ( Matteson, EL; Thongprayoon, C; Ungprasert, P, 2016) |
| "To evaluate whether the elevated blood pressure induced by chronic treatment with N(omega)-nitro-L-arginine methyl ester (L-NAME) contributes to an impairment of endothelium-dependent relaxation (EDR), the effects of chronic treatment of Wistar rats with L-NAME on systolic blood pressure, pulmonary arterial blood pressure and EDR of the pulmonary arteries were studied and compared with those of stroke-prone spontaneously hypertensive rats (SHRSP)." | 3.71 | Endothelium-dependent relaxation in pulmonary arteries of L-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats. ( Kawata, K; Matsuda, K; Negishi, M; Sekiguchi, F; Shimamur, K; Shinomiya, K; Sunano, S; Yamamoto, K, 2002) |
| "Paroxysmal hemicrania has not been associated with ipsilateral weakness, loss of sensation and Horner's syndrome." | 1.56 | Paroxysmal hemicrania masquerading as a stroke in an elderly gentleman: case report. ( Koh, YH; Suantio, AM; Tan, BH, 2020) |
| "Indomethacin treatment reduced microglia activation and the number of ED1+ cells in both 8 and 14 days post injury as compared with controls." | 1.43 | Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. ( Barbosa, MS; Cardoso, MM; DA Silva, MC; Ferreira, EM; Freire, MA; Gomes-Leal, W; Lima, RR; Lopes, RS; Sampaio, AO; Souza, CC, 2016) |
| "The diagnosis of hemicrania continua was made according to the International Headache Society (IHS) criteria." | 1.34 | Hemicrania continua secondary to an ipsilateral brainstem lesion. ( Andrade-Valença, LP; da Silva, WF; Dodick, DW; Valença, MM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chioua, M | 1 |
| Sucunza, D | 1 |
| Soriano, E | 1 |
| Hadjipavlou-Litina, D | 1 |
| Alcázar, A | 1 |
| Ayuso, I | 1 |
| Oset-Gasque, MJ | 1 |
| González, MP | 1 |
| Monjas, L | 1 |
| Rodríguez-Franco, MI | 1 |
| Marco-Contelles, J | 1 |
| Samadi, A | 1 |
| Wang, H | 1 |
| Cui, E | 1 |
| Li, J | 1 |
| Ma, X | 1 |
| Jiang, X | 1 |
| Du, S | 1 |
| Qian, S | 1 |
| Du, L | 1 |
| Tan, BH | 1 |
| Suantio, AM | 1 |
| Koh, YH | 1 |
| Ungprasert, P | 1 |
| Matteson, EL | 1 |
| Thongprayoon, C | 1 |
| Lopes, RS | 1 |
| Cardoso, MM | 1 |
| Sampaio, AO | 1 |
| Barbosa, MS | 1 |
| Souza, CC | 1 |
| DA Silva, MC | 1 |
| Ferreira, EM | 1 |
| Freire, MA | 1 |
| Lima, RR | 1 |
| Gomes-Leal, W | 1 |
| Sekiguchi, F | 1 |
| Yamamoto, K | 1 |
| Matsuda, K | 1 |
| Kawata, K | 1 |
| Negishi, M | 1 |
| Shinomiya, K | 1 |
| Shimamur, K | 1 |
| Sunano, S | 1 |
| Dohi, K | 1 |
| Jimbo, H | 1 |
| Ikeda, Y | 1 |
| Fujita, S | 1 |
| Ohtaki, H | 1 |
| Shioda, S | 1 |
| Abe, T | 1 |
| Aruga, T | 1 |
| Valença, MM | 1 |
| Andrade-Valença, LP | 1 |
| da Silva, WF | 1 |
| Dodick, DW | 1 |
1 review available for indomethacin and Stroke
| Article | Year |
|---|---|
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprof | 2016 |
1 trial available for indomethacin and Stroke
| Article | Year |
|---|---|
Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects.
Topics: Acute Disease; Aged; Body Temperature; Brain; Cryotherapy; Cyclooxygenase Inhibitors; Cytokines; Fem | 2006 |
6 other studies available for indomethacin and Stroke
| Article | Year |
|---|---|
Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blood-Brain Barrier; Cell Hypoxia; C | 2012 |
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazol | 2022 |
Paroxysmal hemicrania masquerading as a stroke in an elderly gentleman: case report.
Topics: Activities of Daily Living; Aged; Brain; Headache; Humans; Indomethacin; Male; Paroxysmal Hemicrania | 2020 |
Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia.
Topics: Animals; Brain Ischemia; Cell Proliferation; Corpus Striatum; Doublecortin Protein; Endothelin-1; Hu | 2016 |
Endothelium-dependent relaxation in pulmonary arteries of L-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats.
Topics: Animals; Arginine; Blood Pressure; Body Weight; Cardiovascular Agents; Endothelium, Vascular; Enzyme | 2002 |
Hemicrania continua secondary to an ipsilateral brainstem lesion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Diseases; Brain Stem; Female; Headache; Humans; Indom | 2007 |