indomethacin has been researched along with Stomach Ulcer in 1200 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration." | 9.08 | Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. ( Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G, 1997) |
| "In the present study, we investigated the gastroprotective potential of HQJZT in a rat model of indomethacin (IND)-induced gastric ulcer and explained the biochemical, cellular, and molecular mechanisms involved." | 8.84 | Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms. ( Cai, X; Gao, Q; Lu, J; Ou, C; Peng, Q; Ren, B; Song, H; Wang, X; Xiong, M; Yu, C; Zeng, M; Zhong, M; Zhou, S, 2024) |
| "Unlike quercetin, chlorogenic acid could not prevent gastric ulcers in indomethacin-treated rats." | 8.31 | Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration. ( Angkhasirisap, W; Boonyong, C; Jianmongkol, S; Kengkoom, K, 2023) |
| " The present work aimed to annotate the secondary metabolites from a butanol fraction of apple leaves (BLE), evaluate the gastro-protective and healing effects of this fraction against indomethacin-induced gastric ulcers in rats and to identify its mechanism of action." | 8.31 | Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats. ( Abdelfattah, MAO; Abdo, W; Drissi, B; El-Shazly, AM; Mahmoud, MF; Nabil, M; Sobeh, M, 2023) |
| "The aim of this study was to investigate the potential protective effects of walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats." | 8.31 | The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats. ( Hao, Y; Kang, J; Li, Y; Liu, R; Liu, X; Mao, R; Yu, X; Zhu, N, 2023) |
| "7 g/kg) or ranitidine (40 mg/kg) were orally administered in rats for three weeks before the induction of gastric ulcer using indomethacin (30 mg/kg, single oral dose)." | 8.31 | Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats. ( Bai, L; Bao, M; Bao, T; Chen, Y; Feng, L; Fu, M; Li, Y; Mu, X; Ta, N; Zhang, J, 2023) |
| "We used the murine re-fed indomethacin (IND) experimental ulcer model." | 8.31 | Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT ( Akiba, Y; Kaunitz, JD; Satoh, H; Urushidani, T, 2023) |
| "This experiment aimed to investigate the preventive effect of ethanol extract (RM) from Chinese sumac fruits on indomethacin-induced gastric ulcer in mice and the underlying mechanisms." | 8.12 | Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis. ( Cai, S; Ma, N; Sun, Y; Yi, J; Zhou, L, 2022) |
| "We investigated the potential gastroprotective effects of chrysin on indomethacin induced gastric ulcers in rats." | 8.12 | Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation. ( Kandemir, FM; Küçükler, S; Yıldırım, S, 2022) |
| "This study investigated the link between forced swim induced acute gastric ulceration, inflammation and MMP-3 along with the possible mechanism of protective efficacy of melatonin." | 8.12 | Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade. ( Chatterjee, A; Choudhary, P; Mishra, VK; Pant, S; Roy, T; Swarnakar, S, 2022) |
| "This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the mechanism behind this protective effect." | 8.12 | RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats. ( Bai, L; Bao, T; Chen, Y; Cho, S; Dai, L; Feng, L; Fu, M; Jin, W; Yu, H; Zhang, J, 2022) |
| " The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy." | 8.02 | Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021) |
| "Curcumin is claimed as a potent protectant against Gastric Ulcer (GU) induced by strong necrotizing agents, including NSAIDs through its antioxidant, anti-inflammatory and gastroprotective activities." | 8.02 | Efficacy of a Chitosan-curcumin Mixture in Treating Indomethacininduced Acute Gastric Ulcer in Rats. ( Kaewsuwan, S; Kuadkaew, S; Mahattanadul, S; Phdoongsombut, N; Ungphaiboon, S, 2021) |
| "This study aimed to investigate the gastroprotective effect of chlorogenic acid (CGA) against Indomethacin (IND)-induced gastric ulcer (GU) in rats and its underlying mechanism, especially through autophagic and apoptotic pathways." | 8.02 | Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling. ( Aboulhoda, BE; Ahmed, AAE; Ahmed, MAE; El-Awdan, SA; Mohanad, M, 2021) |
| " speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs." | 8.02 | Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021) |
| "The results of this study showed that agomelatine usage in indomethacin-induced gastric ulcer model provides beneficial results." | 7.96 | Agomelatine prevents indomethacin-induced gastric ulcer in rats. ( Eraslan, E; Güler, MC; Kurt, N; Tanyeli, A; Yetim, Z, 2020) |
| " This study investigated the involvement of oxidative stress in the healing and protective potentials of aqueous leave extract of Telfairia occidentalis (TO) on indomethacin induced gastric ulcers in adult Sprague Dawley male rats." | 7.96 | Attenuating Effect of Telfairia occidentalis on Oxidative Stress in Indomethacin-induced Gastric Ulcer in Male Rats. ( Adisa, W, 2020) |
| " Gastric ulcerated rats were administered AG, AG + dexamethasone, or pantoprazole after indomethacin exposure." | 7.91 | Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms. ( Abdallah, DM; El-Abhar, HS; El-Lekawy, AM, 2019) |
| " We monitored the intra- and extracellular redox status in the stomach of rats with indomethacin-induced gastric ulcers using OMRI and investigated the relationship with gastric mucosal damage." | 7.91 | In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging. ( Ichikawa, K; Kanbe, T; Mutsumoto, Y; Oda, F; Shigemi, R; Tun, X; Utsumi, H; Yamada, KI; Yasukawa, K, 2019) |
| "Safranal and lansoprazole normalized gastric volume and pH, reduced gastric ulcer area and produced gastric protection." | 7.91 | Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer. ( Erfanparast, A; Farshid, AA; Imani, M; Mirzakhani, N; Salighedar, R; Tamaddonfard, E; Tamaddonfard, S, 2019) |
| "The aim of this paper was to observe the combination therapy with total triterpenoids of Chaenomeles speciosa and omeprazole on indomethacin-induced gastric ulcer in rats, and explore its possible mechanism." | 7.91 | [Therapeutic effect of total triterpenoids of Chaenomeles speciosa combined with omeprazole on gastric ulcer induced by indomethacin in rats]. ( He, HB; He, YM; Li, XM; Li, XQ; Qin, HL; Wang, JZ; Xiong, XJ; Zhang, YF; Zou, K, 2019) |
| "The aim of the study was to investigate the effects of four Aronia melanocarpa-based juices in a rat model of indomethacin-induced gastric ulceration." | 7.91 | Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers. ( Denev, P; Eftimov, M; Georgieva, A; Kuzmanov, A; Kuzmanov, K; Kuzmanova, V; Tzaneva, M; Valcheva-Kuzmanova, S, 2019) |
| "The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats." | 7.88 | Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. ( Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H, 2018) |
| " One of its representative components, the tricyclic triterpenoid β-patchoulone (β-PAE) has demonstrated great anti-inflammatory activity and gastroprotective effect against ethanol-induced gastric injury, but its protective effect against gastric ulcer induced by indomethacin is still unknown." | 7.88 | Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. ( Chen, JN; Dou, YX; Huang, QH; Liang, JL; Liu, YH; Nie, J; Su, ZR; Wu, JZ; Wu, QD; Wu, X; Zhuo, JY, 2018) |
| " The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats." | 7.85 | Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats. ( Alkushi, AGR; Elsawy, NAM, 2017) |
| " After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days." | 7.85 | Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. ( Eyoum Bille, B; Kouitcheu Mabeku, LB; Nanfack Nana, B; Nguepi, E; Tchuenteu Tchuenguem, R, 2017) |
| "These findings suggest that ZnCl(2), enhances the gastroprotective activity ofrisperidone in indomethacin- induced gastric ulcer." | 7.83 | Zinc salt enhances gastroprotective activity of risperidone in indomethacin-induced gastric ulcer. ( Oluwole, FS; Onwuchekwa, C, 2016) |
| "The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats." | 7.83 | Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata. ( Garuba, T; Ismail, NO; Sabiu, S; Sulyman, AO; Sunmonu, TO, 2016) |
| "These results indicated that lycopene might have a protective effect against indomethacin-induced gastric ulcer and oxidative stress in rats." | 7.83 | The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats. ( Avci, H; Boyacioglu, M; Epikmen, ET; Karademir, U; Kum, C; Sekkin, S; Yalinkilinc, HS, 2016) |
| " The optimized GR formulation was examined for its protective effect on the gastric ulcer induced by indomethacin in albino rabbits compared with lactose tablets." | 7.83 | Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits. ( Abu Hashim, II; Badria, FA; Mohamed, EA; Yusif, RM, 2016) |
| " The aim was to scientifically evaluate the possible gastroprotective effect and the underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats." | 7.83 | The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. ( Chen, HM; Chen, XY; Fu, LD; Huang, XQ; Lai, XP; Liang, YZ; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Zhang, X; Zhang, ZB; Zheng, YF, 2016) |
| " In this study, we identified PA-rich food sources and examined the effects of the food materials on indomethacin-induced stomach ulcer." | 7.83 | Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer. ( Afroz, S; Ikoma, T; Kogure, K; Tanaka, T; Tokumura, A; Yagi, A, 2016) |
| "This study investigated the protective effects of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats." | 7.81 | Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats. ( Gomathy, G; Palani, S; Venkatesan, D, 2015) |
| " This study investigated the anti-ulcerogenic and antioxidant activities of aqueous extract of Carica papaya seed against indomethacin-induced peptic ulcer in male rats." | 7.81 | Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. ( Adaja, MC; Ajiboye, TO; Oloyede, HO; Salawu, MO, 2015) |
| " However, there is no report on the gastroprotective effect of ASB against indomethacin-induced gastric ulcer." | 7.81 | Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats. ( Chen, HM; Chen, XY; Feng, XX; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Yu, XT; Zeng, HF; Zhang, X; Zhang, ZB; Zheng, YF, 2015) |
| "The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats." | 7.80 | Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats. ( Agastian, P; Antonisamy, P; Balthazar, JD; Dhanasekaran, M; Duraipandiyan, V; Ignacimuthu, S; Kim, JH, 2014) |
| " In the present work, we evaluated the healing effect of L-theanine on NSAID (indomethacin)-induced gastric ulcer." | 7.80 | L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin. ( Bandyopadhyay, SK; Bera, B; Chatterjee, A; Chatterjee, S; Roy, S, 2014) |
| " This study investigated the possible mechanisms underlying the gastroprotective effect of escin against indomethacin-induced gastric ulcer in mice." | 7.80 | Protective effects of escin against indomethacin-induced gastric ulcer in mice. ( Chu, L; Du, H; Fu, F; Wang, T; Wang, Y; Yang, Y; Yao, L; Zhao, S, 2014) |
| "Gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg)." | 7.79 | Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats. ( El-Moselhy, MA; Morsy, MA, 2013) |
| "The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model." | 7.79 | Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice. ( Acharya, K; Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Khatua, S; Mukherjee, A; Mukherjee, S; Paloi, S, 2013) |
| "The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats." | 7.78 | Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. ( Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M, 2012) |
| "We examined the molecular mechanism of curcumin in a preventive and therapeutic model of indomethacin-induced gastric ulceration with regard to angiogenic processes." | 7.78 | Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling. ( Ganguly, K; Maulik, N; Paul, S; Sharma, AV; Swarnakar, S, 2012) |
| "The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP)." | 7.78 | Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity. ( Abdul Hisam, EE; Hasiah, AH; Norhafizah, M; Othman, F; Rofiee, MS; Vasudevan, M; Zakaria, ZA, 2012) |
| "This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer." | 7.78 | Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. ( Arcanjo Moura, B; Barbosa Filho, JM; de Almeida Leal, LK; de Barros Viana, GS; de Castro Brito, GA; dos Santos e Silva, G; Fragoso de Freitas, AP; Lopes Souto, A; Rios Vasconcelos, E; Santos Cerqueira, G; Silveira Macedo, D; Souccar, C, 2012) |
| "The mechanism of indomethacin-induced gastric ulcer healing by ellagic acid (EA) in experimental mice model is described in our study." | 7.78 | Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. ( Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A, 2012) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 7.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| " Hence, the potential of a new water-soluble GPx mimic, DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) in healing the indomethacin-induced stomach ulceration in mice was examined." | 7.78 | DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) accelerates healing of indomethacin-induced stomach ulceration in mice. ( Chakraborty, S; Chattopadhyay, S; Iwaoka, M; Priyadarsini, KI; Subramanian, M; Yadav, SK, 2012) |
| "9% for indomethacin-induced acute gastric ulcer (IAGU) rats, respectively] than those of ZAC alone due to the significantly slower renal clearance (CL(R))." | 7.77 | Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. ( Choi, YH; Kim, YG; Lee, M; Lee, MG; Lee, U; Oh, E; Suh, JH, 2011) |
| " Diabetes was induced in rats by a single dose of streptozotocin (STZ) followed by gastric ulceration using indomethacin, and melatonin's action was studied by its application prior to indomethacin exposure." | 7.77 | Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. ( Pradeepkumar Singh, L; Swarnakar, S; Vivek Sharma, A, 2011) |
| " Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice." | 7.77 | Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011) |
| "5]undecan-8-oxyl (compound 1) and 4-oxo-2,2,6,6-tetraethylpiperidine-1-oxyl (compound 2) in the prevention of gastric ulcers in adjuvant arthritis rats treated with indomethacin was evaluated by monitoring the reaction of reactive oxygen species in gastric tissue with Overhauser-enhanced magnetic resonance imaging (OMRI)." | 7.77 | Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats. ( Deguchi, H; Ichikawa, K; Kinoshita, Y; Mito, F; Naganuma, T; Sakai, K; Sato, S; Utsumi, H; Yamada, K; Yamasaki, T; Yamato, M; Yasukawa, K, 2011) |
| "The gastro-protective and antioxidant effects of methanol extract of Ficus asperifolia bark on indomethacin induced gastric ulcer were investigated in male rats." | 7.77 | Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats. ( Bolarinwa, AF; Oyeyemi, WA; Raji, Y; Shittu, ST, 2011) |
| " The present study was conducted to test for the possible gastroprotective effect of nicotinamide utilizing an acute indomethacin-induced gastric ulcer model." | 7.76 | Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent. ( Abdallah, DM, 2010) |
| "To evaluate, for the first time, the efficacy of copper-indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial oxidative damage, and renal toxicity in rat models." | 7.76 | Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. ( Bonin, AM; Davies, NM; Dillon, CT; Fukuda, C; Hambley, TW; Lay, PA; Teng, XW; Yáñez, JA, 2010) |
| "Gastric ulcers were induced in mice with a single dose of indomethacin." | 7.76 | Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine. ( Bandyopadhyay, SK; Chatterjee, A; Chattopadhyay, S; Dey, A; Guha, P, 2010) |
| "The protective effects of telmisartan, the angiotensin II-receptor antagonist, were investigated in rats with type 2 diabetes mellitus exposed to acute gastric ulceration." | 7.76 | Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. ( Al-Sultan, AI; Fouad, AA; Gomaa, W; Yacoubi, MT, 2010) |
| " We reported previously that melatonin (N-acetyl-5-methoxy tryptamine), an antioxidant and anti-inflammatory agent, prevents indomethacin-induced gastric ulcers." | 7.76 | Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. ( Ganguly, K; Reiter, RJ; Sharma, AV; Swarnakar, S, 2010) |
| "The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model." | 7.76 | Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G, 2010) |
| "This study investigated the possible mechanisms underlying the gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats." | 7.75 | Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. ( Amin, RS; Hassan, MK; Heeba, GH, 2009) |
| "The role of the arginine-metabolism in the healing action of the Myristica malabarica phenol malabaricone B (mal B) and omeprazole against indomethacin-induced stomach ulceration in mouse was investigated." | 7.75 | Regulation of arginase/nitric oxide synthesis axis via cytokine balance contributes to the healing action of malabaricone B against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B, 2009) |
| "We conclude that ATL-313 does not inhibit the mucosal damaging effect of indomethacin, but it does block secondary injury due to stomach inflammation." | 7.75 | Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. ( Jin, M; Koizumi, S; Linden, J; Odashima, M; Ohnishi, H; Otaka, M; Watanabe, S, 2009) |
| "Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice." | 7.75 | Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. ( Bandyopadhyay, SK; Chattopadhyay, S; Dey, A; Guha, P, 2009) |
| " polium) in indomethacin-induced gastric ulcer in rats." | 7.75 | The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats. ( Amini, M; Azarpira, N; Fattahi, MR; Mehrabani, D; Panjehshahin, MR; Rezaee, A; Saberi-Firouzi, M; Tanideh, N, 2009) |
| "Telmisartan is an angiotensin II T1 receptor blocker (ARB) with partial peroxisome proliferator-activated receptor gamma (PPARgamma) agonistic properties; two actions that are suggested to be efficacious for protecting against gastric ulcers." | 7.75 | Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats. ( Amin, E; Ashour, O; Morsy, M; Rofaeil, R, 2009) |
| "To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers." | 7.75 | EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009) |
| " The results of ulcerogenic studies indicate that the gastric ulcerogenecity of plant extract is lower than the indomethacin in the rat's stomach." | 7.74 | The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. ( Heidari, MR; Khazaeli, P; Mehrabani, M; Pardakhty, A; Vahedian, M; Yakhchali, M; Zahedi, MJ, 2007) |
| " In the present study, we examined the effect of alendronate on the healing of acetic acid-induced gastric ulcers in rats and investigated the mechanism involved in this action both in vivo and in vitro using the rat gastric epithelial cell line (RGM1)." | 7.74 | Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. ( Aihara, E; Amagase, K; Hayashi, S; Nishikawa, K; Takeuchi, K, 2007) |
| "APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties." | 7.74 | Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Bhattacharya, S; Chattopadhyay, S, 2007) |
| "The healing activity of malabaricone B and malabaricone C, the major antioxidant constituents of the spice Myristica malabarica against the indomethacin-induced gastric ulceration in mice has been studied." | 7.74 | Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK, 2008) |
| "The drugs, mal B and mal C could effectively heal indomethacin-induced stomach ulceration in mice by promoting angiogenesis." | 7.74 | Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration. ( Bandivdeker, AH; Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B, 2008) |
| "The present study was undertaken to evaluate the potential of the rhizomes of the Indian medicinal plant, Picrorhiza kurroa in healing indomethacin-induced acute stomach ulceration in mice and examine its capacity to modulate oxidative stress and the levels of prostaglandin (PGE2) and EGF during the process." | 7.74 | Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B; Nag, SK, 2008) |
| "Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels." | 7.74 | Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S, 2008) |
| " However, the role of MMPs in indomethacin-induced gastric ulcer and its healing process are not clearly understood." | 7.73 | Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. ( Banerjee, A; Ganguly, K; Kundu, P; Maity, P; Sharma, AV; Swarnakar, S, 2005) |
| "Reactive oxygen species (ROS) are thought to be involved in the gastric ulcer formation induced by indomethacin, a typical nonsteroidal anti-inflammatory drug." | 7.73 | Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats. ( Shigemi, R; Soeda, T; Tsuneyoshi, M; Utsumi, H; Yamada, K; Yao, T; Yasukawa, K, 2006) |
| "To study the effects of amphetamine, an indirect-acting adrenomimetic compound on the indomethacin-induced gastric ulcerations in rats." | 7.73 | Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats. ( Birt, MA; Cuparencu, B; Dumitrascu, DL; Krausz, TL; Sandor, V, 2006) |
| " (methanolic extract) and its action against indomethacin (a non-steroidal anti-inflammatory drug) plus pyloric ligation (PL)-induced gastric ulcers in rats." | 7.73 | Antisecretory and antiulcer activity of Asparagus racemosus Willd. against indomethacin plus phyloric ligation-induced gastric ulcer in rats. ( Bhatnagar, M; Sisodia, SS, 2006) |
| "We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation." | 7.72 | Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003) |
| "The acetone soluble fraction from a crude methanol extract of Stryphnodendron adstringens stem bark (AFSAB) was evaluated in acute (ethanol, indomethacin and hypothermic restraint-stress) and chronic (acetic acid) models of gastric ulceration and on basal and bethanechol-stimulated gastric acid secretion in rats." | 7.71 | The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats. ( Lima, JC; Martins, DT; Rao, VS, 2002) |
| "We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism." | 7.71 | Effects of diacerein on indomethacin-induced gastric ulceration. ( Ohmori, K; Tamura, T; Yokoyama, T, 2001) |
| " at an effective anti-inflammatory dose to rats with pre-existing acetic acid-induced gastric ulcer, NS-398 caused a statistically significant delay of ulcer healing." | 7.70 | Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats. ( Dyer, RD; Gilbertsen, RB; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B; Schrier, D; Song, Y, 1998) |
| "The healing of experimental gastric ulcers induced in rats is consistently delayed upon chronic treatment with indomethacin." | 7.70 | A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers. ( Amagase, K; Okabe, S, 1999) |
| " Our aim is to determine the antiinflammatory activity of deferiprone, an oral iron chelator, in experimental colitis and gastritis." | 7.70 | Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats. ( Ablin, J; Karmeli, F; Okon, E; Rachmilewitz, D; Shalev, O, 1999) |
| " In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection." | 7.70 | The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000) |
| " The spatial and temporal gelatinolytic activities of MMP-2 and MMP-9 were analyzed as a function of ulcer age, in homogenates of rat, indomethacin-induced, chronic gastric ulcers." | 7.70 | Matrix metalloproteinases 2 and 9 in indomethacin-induced rat gastric ulcer. ( Ahonen, J; Inkinen, K; Lempinen, M; Wolff, H, 2000) |
| "The influence of (+/-)-verapamil and hydralazine on stress- and various chemically-induced gastric ulcers in rats together with their influence on various biochemical parameters which affect the development of the induced ulcers was examined." | 7.69 | Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats. ( al-Bekairi, AM; al-Rajhi, AM; Tariq, M, 1994) |
| "Indomethacin delays healing of experimental gastric ulcers." | 7.69 | Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin. ( Flogerzi, B; Halter, F; Peskar, BM; Schmassmann, A; Tarnawski, A; Varga, L, 1995) |
| "Effects of treatment with free radical scavengers in the healing process of acetic acid-induced gastric ulcer on the ulcer aggravation induced by indomethacin were investigated." | 7.69 | Effects of free radical scavengers on indomethacin-induced aggravation of gastric ulcer in rats. ( Kondo, M; Matsuyama, K; Naito, Y; Nishimura, S; Yagi, N; Yoshikawa, T, 1995) |
| " Homozygous Ptgs1 mutant mice survive well, have no gastric pathology, and show less indomethacin-induced gastric ulceration than wild-type mice, even though their gastric prostaglandin E2 levels are about 1% of wild type." | 7.69 | Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. ( Chulada, PC; Ghanayem, BI; Goulding, EH; Kim, HS; Kluckman, KD; Langenbach, R; Lee, CA; Loftin, CD; Mahler, JF; Morham, SG; Smithies, O; Tiano, HF, 1995) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 7.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process." | 7.69 | Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995) |
| "We have examined whether or not repeated treatment with indomethacin delays the healing of kissing gastric ulcers induced in rats." | 7.69 | Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats. ( Nozue, C; Okabe, S; Tsukimi, Y, 1996) |
| " This same dose of omeprazole significantly reduced gastric ulcer formation induced by indomethacin despite significant (> 80%) inhibition of gastric mucosal prostaglandin E2 (PGE2) formation." | 7.69 | Omeprazole prevents indomethacin-induced gastric ulcers in rabbits. ( Feldman, M; Kallal, SM; Lee, M, 1996) |
| "The study was performed to examine whether indomethacin administered during the initial period of acetic acid-induced gastric ulcer healing affects future ulcer recurrence." | 7.69 | Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins. ( Arakawa, T; Fukuda, T; Higuchi, K; Kobayashi, K; Takaishi, O; Tarnawski, A; Watanabe, T; Yamasaki, K, 1996) |
| "We found indomethacin aggravates healed gastric ulcers (ulcer relapse) in rats." | 7.69 | Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. ( Asano, S; Inada, I; Maeda, R; Murakami, I; Sato, F; Satoh, H; Shino, A, 1997) |
| " Experimental gastric lesions were induced by water-immersion restraint stress, indomethacin and 80% ethanol in rats; whereas duodenal ulcers were produced by treatment of rats with cysteamine." | 7.69 | Effect of quinacrine, a phospholipase A2 inhibitor on stress and chemically induced gastroduodenal ulcers. ( Al Moutaery, AR; Tariq, M, 1997) |
| "We examined the effect of NC-1300-O-3 on the healing of acetic acid-induced gastric ulcers in male Donryu rats." | 7.68 | Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats. ( Inoue, K; Okabe, S; Takagi, K, 1993) |
| "Repeated administration of indomethacin delays the healing of acetic acid-induced gastric ulcers in rats, but the underlying mechanism remains unclear." | 7.68 | Mechanism by which indomethacin delays gastric ulcer healing in the rat: inhibited contraction of the ulcer base. ( Ogihara, Y; Okabe, S, 1993) |
| "Repeated administration of indomethacin or prednisolone for 2 weeks apparently delayed the healing of initial gastric ulcers induced by acetic acid injection in rats." | 7.68 | Effects of indomethacin and prednisolone on the different stages of healing of acetic acid-induced gastric ulcers in the rat. ( Ogihara, Y; Okabe, S, 1993) |
| "Repeated administration of indomethacin markedly delays spontaneous healing of experimental gastric ulcers induced in rats." | 7.68 | Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. ( Hirose, H; Okabe, S; Takeuchi, K, 1991) |
| "Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats." | 7.68 | Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats. ( Nagai, H; Okabe, S; Wang, JY, 1990) |
| "We examined the effects of orally administered human epidermal growth factor (hEGF) on healing of acetic acid-induced gastric ulcers in rats." | 7.68 | Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. ( Imoto, Y; Kuwahara, Y; Okabe, S; Sunagawa, Y, 1990) |
| "Levamisole, in doses similar to those required to observe immunostimulation in animals, antagonized dose-dependently, in rats, gastric ulcers produced by necrotizing agents (HCl and ethanol) and NSAIDs (indomethacin and piroxicam) without affecting the anti-inflammatory properties of these latter drugs." | 7.67 | The effect of levamisole on gastric ulcers induced in the rat by anti-inflammatory and necrotizing agents. ( Evangelista, S; Maggi, CA; Meli, A, 1984) |
| " Acutely induced gastric ulcers or erosions such as Shay ulcers, water-immersion stress-, indomethacin-, aspirin-, or prednisolone-induced erosions were all markedly inhibited by oral or intraduodenal administration of 10-100 mg/kg of omeprazole." | 7.67 | Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984) |
| "The interaction between reserpine and nonsteroidal anti-inflammatory agents ( NSAIA ) in producing experimental gastric ulcers was studied in rats." | 7.67 | Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats. ( Radmanović, BZ; Sćepović, Z, 1984) |
| "We examined the effect of human epidermal growth factor (hEGF) on the healing rate of gastric ulcers induced in rats." | 7.67 | Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. ( Kuwahara, Y; Okabe, S, 1989) |
| "Effects of systemically administered gamma-aminobutyric acid (GABA) on indomethacin-induced gastric ulceration were studied in rats." | 7.67 | Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors. ( Hara, S; Morioka, S; Satoh, K; Yanagihara, S, 1988) |
| "We examined the mechanism by which repeated administration of indomethacin significantly delays the natural healing of experimental gastric ulcers induced in rats." | 7.67 | Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin. ( Okabe, S; Takeuchi, K; Wang, JY; Yamasaki, S, 1989) |
| "Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug." | 7.67 | Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. ( Fielder, FG; Ginsberg, RS; Godin-Ostro, E; Slusher, MA; Soehngen, EC; Weiner, AL, 1988) |
| "We investigated whether the trophic actions of prostaglandins, omeprazole, and indomethacin on gastric mucosa lead to accelerated healing of gastric ulcers in the rat." | 7.67 | Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. ( Baumgartner, A; Halter, F; Inauen, W; Kayser, S; Koelz, HR; Schürer-Maly, CC; Wyss, PA, 1988) |
| "The purpose of these studies was to determine the role played by endogenous prostaglandins in the development of gastric ulcers produced by indomethacin, and of duodenal ulcers produced by mepirizole in rats." | 7.67 | Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats. ( Jacobson, ED; Joffe, SN; Robert, A; Tabata, K, 1987) |
| "Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats." | 7.67 | Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985) |
| "With the carrageenin food oedema assay, we studied in rats the effects of indomethacin on inflammation, gastric ulcers and lipid peroxide levels." | 7.67 | Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats. ( Planas, JM; Puig-Parellada, P, 1985) |
| " D-penicillamine showed a dose dependent antiulcerogenic effect in both gastric ulcer models." | 7.67 | The effect of D-penicillamine in different experimental gastric ulcer models in the rat. ( Bálint, GA; Varró, V, 1985) |
| "Gastric ulcer was provoked by indomethacine (20 mg/kg s." | 7.66 | The relationships between indomethacine-induced gastric ulcer, ulcer protection by cimetidine and prostacyclin and the cAMP system of the gastric fundic mucosa in the rat. ( Bata, M; Fiegler, M; Jávor, T; Morón, F; Mózsik, G, 1982) |
| "Effects of indomethacin on healed partially healed gastric ulcers in the dog were studied." | 7.66 | Does indomethacin activate healed gastric ulcers in the dog? ( Okabe, S; Tabata, K, 1981) |
| "Experimental models of chronic and acute peptic ulcerations were produced in the albino rats by means of prolonged starvation and indomethacin administration." | 7.66 | Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats. ( Elegbe, RA, 1978) |
| "Bilateral adrenalectomy markedly aggravated gastric ulcers in rats induced by 5 or 20 mg/kg of indomethacin." | 7.66 | The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat. ( Kasuya, Y; Okabe, S; Urushidani, T, 1979) |
| "The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied." | 7.65 | Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977) |
| "Indomethacin produces gastric ulceration in the rat when given by subcutaneous injection." | 7.65 | Effect of salbumatol on acute gastric ulceration induced by indomethacin in the rat. ( Curwain, BP; Fielding, LP; Raute, M, 1977) |
| "Ionic permeability of the gastric mucosa was measured in six patients with an acute exacerbation of severe generalized rheumatoid arthritis receiving either aspirin and prednisone or aspirin and indomethacin as therapy." | 7.65 | Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis. ( Clifton, JA; Ivey, KJ, 1974) |
| "Dyspeptic symptoms, gastrointestinal bleeding, or the development of anaemia without dyspepsia in patients treated with indomethacin may be manifestations of peptic ulceration." | 7.64 | Gastric ulceration occurring during indomethacin therapy. ( Hart, FD; Huskisson, EC; Taylor, RT; Trapnell, DH; Whitehouse, GH, 1968) |
| "Indomethacin is an indol derivative, non-steroidal, anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects." | 6.46 | Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. ( Albayrak, A; Bilici, M; Cadirci, E; Halici, Z; Suleyman, H, 2010) |
| "Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects." | 5.91 | Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1. ( El-Demerdash, E; Hamza, SE; Wahdan, SA, 2023) |
| "The prevalence of gastric ulcers is increasing worldwide, especially those brought on by non-steroidal anti-inflammatory drugs (NSAIDS), so prevention is extremely crucial." | 5.91 | Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats. ( Abu-Risha, SE; Elsisi, AE; Mekky, EF, 2023) |
| "Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties." | 5.91 | Effect of felodipine on indomethacin-induced gastric ulcers in rats. ( Akbaş, EM; Akbaş, N; Gülaboğlu, M; Mammadov, R; Süleyman, B; Süleyman, H, 2023) |
| "Metformin (500 mg/kg) was given orally for 3 days prior to indomethacin or ethanol challenge." | 5.72 | The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats. ( Alican, İ; Aydın, B; Cabadak, H; Cumbul, A; Ercan, F; İpek, BE; Yüksel, M, 2022) |
| "Gastric ulcer has been a major cause of morbidity and mortality worldwide, and it has been linked to factors such as nutritional deficiency, smoking, stress, and continuous intake of non-steroidal antiinflammatory drugs (NSAIDs)." | 5.72 | Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model. ( Carvalho, MF; Costa, EA; Fajemiroye, JO; Fava, SA; Ghedini, PC; Gil, ES; Gomes, EH; Macedo, IYL; Martins, JLR; Pinto, EMH; Rocha, FF; Silva, DM; Silva, ON, 2022) |
| "Olmesartan (OLM) has potent anti-oxidant and anti-inflammatory characters, yet having limited bioavailability." | 5.62 | Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway. ( Darwish, SF; El-Dakroury, WA; Radwan, E; Sallam, AM, 2021) |
| "Rheumatoid arthritis is an autoimmune inflammatory disease with progressive degradation of cartilage and joints." | 5.62 | Nerolidol-beta-cyclodextrin inclusion complex enhances anti-inflammatory activity in arthritis model and improves gastric protection. ( Cavalcanti, MD; de Albuquerque Júnior, RLC; de Lima, CM; de Souza Araújo, AA; de Souza Carvalho, FM; de Souza, EPBSS; Dos Santos Lima, B; Gomes, MVLD; Júnior, LJQ; Marreto, RN; Shanmugan, S; Silva, LAS, 2021) |
| "Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels." | 5.62 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021) |
| "Pinocembrin (PINO) is a natural flavonoid retaining anti-microbial, anti-oxidant, and anti-inflammatory activities." | 5.62 | Protective and therapeutic effects of the flavonoid "pinocembrin" in indomethacin-induced acute gastric ulcer in rats: impact of anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms. ( El-Demerdash, AA; Elsherbiny, DA; Esmat, A; Menze, ET; Tadros, MG, 2021) |
| "Gastric ulcers were induced in male Sprague-Dawley (SD) rats with a single oral dose of 150 mg/kg IND." | 5.56 | Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway. ( Cai, X; Chen, X; Hou, X; Peng, J; Peng, Q; Song, H; Xu, F; Yang, T; Yu, R; Zeng, M, 2020) |
| "Gastric ulcer is one of the most prevalent diseases worldwide." | 5.51 | Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach. ( Amiri-Dashatan, N; Dadpay, M; Farrokhi Yekta, R; Goshadrou, F; Koushki, M, 2019) |
| "The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide." | 5.51 | Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice. ( Alves, GM; Assis, ALEM; Athaydes, BR; Campagnaro, BP; Gomes, JVD; Gonçalves, RCR; Kitagawa, RR; Kuster, RM; Nogueira, BV; Pereira, TMC; Rodrigues, RP; Silveira, D, 2019) |
| "Gastric ulcer is a common problem affecting the gastrointestinal tract." | 5.51 | A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats. ( Abdelwahed, MK; Ahmed, EI; Boushra, AF; Elsayed, AM; Ibrahim, NA, 2019) |
| "Thymol is a monoterpene phenol with many different pharmacological activities." | 5.48 | Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model. ( Aysin, F; Cerig, S; Erol, HS; Geyikoglu, F; Koc, K; Ozek, NS; Yilmaz, EG, 2018) |
| " Each rat to receive nebivolol and omeprazole was given the agent orally (by gavage) daily for 10 days prior to induction of ulcer by oral dosing with INDO." | 5.43 | Nebivolol prevents indomethacin-induced gastric ulcer in rats. ( El-Ashmawy, NE; El-Bahrawy, HA; Khedr, EG; Selim, HM, 2016) |
| "Aliskiren was able to inhibit indomethacin-induced ulcer formation." | 5.43 | Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Kose, D; Polat, B; Topcu, A, 2016) |
| "Indomethacin (IND) is a non-steroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions." | 5.39 | Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. ( Abbas, AM; Sakr, HF, 2013) |
| "Pretreatment with candesartan for 10 days reduced significantly the ulcer index induced by indomethacin injection." | 5.38 | Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats. ( Awad, AS; El Morsy, EM; Kamel, R, 2012) |
| "Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions." | 5.37 | Curative effect of selenium against indomethacin-induced gastric ulcers in rats. ( Kim, BW; Kim, JH; Kwon, HJ; Nam, SW, 2011) |
| "Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e." | 5.36 | Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010) |
| "Rats treated with indomethacin revealed mucosal hemorrhagic lesions, increased microvascular permeability and inhibited prostaglandin E₂ and mucus content." | 5.36 | Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E₂, nitric oxide and redox status in indomethacin-induced gastric ulcer model. ( El-Abhar, HS, 2010) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 5.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "Amiodarone is a widely used antiarrhythmic agent." | 5.34 | Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats. ( Bayir, Y; Cadirci, E; Dengiz, GO; Halici, Z; Odabasoglu, F; Suleyman, H, 2007) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 5.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Gastric ulcer is a source of visceral pain." | 5.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| "Ketoconazole treatment resulted in significant protection against stress; indomethacin and ethanol induced gastric lesions in rats." | 5.32 | Protective effect of ketoconazole against experimentally induced gastric ulcers in rats. ( Al Moutaery, AR, 2003) |
| "The indomethacin treatment of the premedicated animals with the drug hardly affected either the malondialdehyde (MDA) or superoxide dismutase (SOD) level in gastric tissue while the ulcerative agent itself significantly enhanced both the levels." | 5.31 | The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. ( Bandyopadhyay, SK; Pakrashi, A; Pakrashi, SC, 2000) |
| "Pre-treatment with indomethacin significantly reduced the protective effect of the extract against HCl/ethanol solution to 31%." | 5.31 | Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats. ( Dimo, T; Dongo, E; Tan, PV, 2000) |
| " Gastrointestinal ulceration was assessed, four hours after a single dose and 24 hours following the last dose of a chronic four day dosing regimen, by counting the number of lesions and ulcers present." | 5.30 | Comparative evaluation of the severity of gastric ulceration by solid dispersions and coprecipitates of indomethacin. ( Degennaro, MD; Karnachi, AA; Khan, MA; Reddy, IK, 1997) |
| "Gastric ulcers were produced 5 days after submucosal injection of 20% acetic acid (0." | 5.29 | Effect and mechanism of sucralfate on healing of acetic acid-induced gastric ulcers in rats. ( Ogihara, Y; Okabe, S, 1993) |
| "Indomethacin is a potent and efficacious antiinflammatory agent." | 5.28 | Influence of indomethacin amphoteric gel on gastric ulcerogenicity and absorption of indomethacin in rats. ( Dent, J; Eickhoff, WM; Liversidge, GG, 1989) |
| "Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration." | 5.08 | Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. ( Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G, 1997) |
| " After 30 minutes gastric ulcers were induced by the intragastric application of NSAIDs (20 mg/kg indomethacin, 200 mg/kg aspirin, 200 mg/kg ibuprofen, or 50 mg/kg diclofenac)." | 5.08 | Reduction of non-steroidal anti-inflammatory drug induced gastric injury and leucocyte endothelial adhesion by octreotide. ( Angermüller, S; Engel, G; Görlach, E; Kusterer, K; Oldenburg, A; Pohl, T; Scheiman, JM; Tillner, A; Usadel, KH, 1997) |
| " One hundred patients, free from endoscopically detectable lesions of the gastroduodenal mucosa, affected either by rheumatoid arthritis or osteoarthritis, and candidates for NSAID therapy, were randomly allocated either to 200 mg sulglycotide three times daily (n = 50) or to an indistinguishable placebo (n = 50) for 4 weeks, together with standard NSAID administration (50 mg diclofenac three times daily (n = 50); 50 mg indomethacin three times daily (n = 50))." | 5.07 | Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients. ( Ardizzone, S; Bianchi Porro, G; Caruso, I; Montrone, F; Petrillo, M, 1993) |
| "In the present study, we investigated the gastroprotective potential of HQJZT in a rat model of indomethacin (IND)-induced gastric ulcer and explained the biochemical, cellular, and molecular mechanisms involved." | 4.84 | Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms. ( Cai, X; Gao, Q; Lu, J; Ou, C; Peng, Q; Ren, B; Song, H; Wang, X; Xiong, M; Yu, C; Zeng, M; Zhong, M; Zhou, S, 2024) |
| " pylori infection, indomethacin and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed acetic acid ulcers; and 2) whether or not eradication of the bacteria with drugs at specified times after infection prevents the development of mucosal changes, including gastric adenocarcinoma." | 4.81 | [Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. ( Ebata, M; Keto, Y; Okabe, S, 2001) |
| " In this regard, Sarcophyton glaucum-derived secondary metabolites were examined for their preventive activities against indomethacin-induced gastric ulcer." | 4.31 | Cembranoids from the Red Sea soft coral Sarcophyton glaucum protect against indomethacin-induced gastric injury. ( Abdel-Naim, AB; Alarif, WM; Alorfi, HS; Alqarni, NM; Bawakid, NO, 2023) |
| "Unlike quercetin, chlorogenic acid could not prevent gastric ulcers in indomethacin-treated rats." | 4.31 | Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration. ( Angkhasirisap, W; Boonyong, C; Jianmongkol, S; Kengkoom, K, 2023) |
| " The present work aimed to annotate the secondary metabolites from a butanol fraction of apple leaves (BLE), evaluate the gastro-protective and healing effects of this fraction against indomethacin-induced gastric ulcers in rats and to identify its mechanism of action." | 4.31 | Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats. ( Abdelfattah, MAO; Abdo, W; Drissi, B; El-Shazly, AM; Mahmoud, MF; Nabil, M; Sobeh, M, 2023) |
| "), the gastroprotective activity was assessed in various animal models of stomach ulcers caused by acidified ethanol, water constraint stress, indomethacin, (acute), and acid acetic (chronic)." | 4.31 | Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves. ( Arunachalam, K; Damazo, AS; Figueiredo, FF; Lima, JCDS; Martins, DTO; Pavan, E; Silva, MJD, 2023) |
| "The aim of this study was to investigate the potential protective effects of walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats." | 4.31 | The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats. ( Hao, Y; Kang, J; Li, Y; Liu, R; Liu, X; Mao, R; Yu, X; Zhu, N, 2023) |
| " The therapeutic effect of AH seeds extract against indomethacin-induced ulcer in rat model indicated the regenerated membrane integrity, with improved cellular functions and mucus thickness." | 4.31 | Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis. ( Idris, S; Khushtar, M; Mishra, A, 2023) |
| "7 g/kg) or ranitidine (40 mg/kg) were orally administered in rats for three weeks before the induction of gastric ulcer using indomethacin (30 mg/kg, single oral dose)." | 4.31 | Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats. ( Bai, L; Bao, M; Bao, T; Chen, Y; Feng, L; Fu, M; Li, Y; Mu, X; Ta, N; Zhang, J, 2023) |
| "We used the murine re-fed indomethacin (IND) experimental ulcer model." | 4.31 | Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT ( Akiba, Y; Kaunitz, JD; Satoh, H; Urushidani, T, 2023) |
| "This experiment aimed to investigate the preventive effect of ethanol extract (RM) from Chinese sumac fruits on indomethacin-induced gastric ulcer in mice and the underlying mechanisms." | 4.12 | Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis. ( Cai, S; Ma, N; Sun, Y; Yi, J; Zhou, L, 2022) |
| "We investigated the potential gastroprotective effects of chrysin on indomethacin induced gastric ulcers in rats." | 4.12 | Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation. ( Kandemir, FM; Küçükler, S; Yıldırım, S, 2022) |
| "This study investigated the link between forced swim induced acute gastric ulceration, inflammation and MMP-3 along with the possible mechanism of protective efficacy of melatonin." | 4.12 | Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade. ( Chatterjee, A; Choudhary, P; Mishra, VK; Pant, S; Roy, T; Swarnakar, S, 2022) |
| "This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the mechanism behind this protective effect." | 4.12 | RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats. ( Bai, L; Bao, T; Chen, Y; Cho, S; Dai, L; Feng, L; Fu, M; Jin, W; Yu, H; Zhang, J, 2022) |
| " The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy." | 4.02 | Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021) |
| "Curcumin is claimed as a potent protectant against Gastric Ulcer (GU) induced by strong necrotizing agents, including NSAIDs through its antioxidant, anti-inflammatory and gastroprotective activities." | 4.02 | Efficacy of a Chitosan-curcumin Mixture in Treating Indomethacininduced Acute Gastric Ulcer in Rats. ( Kaewsuwan, S; Kuadkaew, S; Mahattanadul, S; Phdoongsombut, N; Ungphaiboon, S, 2021) |
| "This study aimed to investigate the gastroprotective effect of chlorogenic acid (CGA) against Indomethacin (IND)-induced gastric ulcer (GU) in rats and its underlying mechanism, especially through autophagic and apoptotic pathways." | 4.02 | Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling. ( Aboulhoda, BE; Ahmed, AAE; Ahmed, MAE; El-Awdan, SA; Mohanad, M, 2021) |
| " Here, we investigated the gastroprotective potential of the leaf extract on indomethacin-induced gastric ulcer in rats and explored the involved mechanism(s) of action." | 4.02 | Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats. ( Abdelfattah, MAO; Abdo, W; El Kharrassi, Y; El-Shazly, AM; Mahmoud, MF; Nabil, M; Sobeh, M, 2021) |
| " speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs." | 4.02 | Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021) |
| "Liquid raft-forming formulations comprising solid dispersions of glycoside-rich Centella asiatica extract and Eudragit® EPO (GR-SD) were developed to achieve prolonged delivery of the glycosides, asiaticoside (AS) and madecassoside (MS) in the stomach and thus increase the effectiveness of gastric ulcer treatment." | 3.96 | Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment. ( Issarachot, O; Mahattanadul, S; Puttarak, P; Wannasarit, S; Wiwattanapatapee, R, 2020) |
| "The results of this study showed that agomelatine usage in indomethacin-induced gastric ulcer model provides beneficial results." | 3.96 | Agomelatine prevents indomethacin-induced gastric ulcer in rats. ( Eraslan, E; Güler, MC; Kurt, N; Tanyeli, A; Yetim, Z, 2020) |
| " This study investigated the involvement of oxidative stress in the healing and protective potentials of aqueous leave extract of Telfairia occidentalis (TO) on indomethacin induced gastric ulcers in adult Sprague Dawley male rats." | 3.96 | Attenuating Effect of Telfairia occidentalis on Oxidative Stress in Indomethacin-induced Gastric Ulcer in Male Rats. ( Adisa, W, 2020) |
| " Gastric ulcerated rats were administered AG, AG + dexamethasone, or pantoprazole after indomethacin exposure." | 3.91 | Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms. ( Abdallah, DM; El-Abhar, HS; El-Lekawy, AM, 2019) |
| " We monitored the intra- and extracellular redox status in the stomach of rats with indomethacin-induced gastric ulcers using OMRI and investigated the relationship with gastric mucosal damage." | 3.91 | In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging. ( Ichikawa, K; Kanbe, T; Mutsumoto, Y; Oda, F; Shigemi, R; Tun, X; Utsumi, H; Yamada, KI; Yasukawa, K, 2019) |
| " However, there is lack of evidence that fluvoxamine recruits Hsp70 to affect stress-induced gastric ulcer." | 3.91 | Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70. ( Ardianto, C; Aryani, T; Dinintia, Y; Khotib, J; Nisak, K; Oktavia, R; Rahmadi, M; Ratnasari, A; Shinta, DW, 2019) |
| " This study aimed to investigate the possible gastroprotective effects of saccharification on the indomethacin (IND)-induced gastric ulcers in rats using Weissella cibaria- and Saccharomyces cerevisiae-triple fermented H." | 3.91 | Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats. ( Bashir, KMI; Cho, HR; Choi, JS; Jung, GW; Ku, SK; Lim, JM; Park, DC; Park, SJ; Song, CH, 2019) |
| "Safranal and lansoprazole normalized gastric volume and pH, reduced gastric ulcer area and produced gastric protection." | 3.91 | Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer. ( Erfanparast, A; Farshid, AA; Imani, M; Mirzakhani, N; Salighedar, R; Tamaddonfard, E; Tamaddonfard, S, 2019) |
| "Gastric ulceration was experimentally generated by administration of single oral doses of indomethacin (30 mg/kg) to fasted rats." | 3.91 | Antiulcer activity of Cyperus alternifolius in relation to its UPLC-MS metabolite fingerprint: A mechanistic study. ( Abdallah, HMI; Efferth, T; Elshamy, AI; Farag, MA; Farrag, ARH; Gendy, AEGE; Hegazy, MF; Khattab, AR; Mohamed, TA, 2019) |
| "The aim of this paper was to observe the combination therapy with total triterpenoids of Chaenomeles speciosa and omeprazole on indomethacin-induced gastric ulcer in rats, and explore its possible mechanism." | 3.91 | [Therapeutic effect of total triterpenoids of Chaenomeles speciosa combined with omeprazole on gastric ulcer induced by indomethacin in rats]. ( He, HB; He, YM; Li, XM; Li, XQ; Qin, HL; Wang, JZ; Xiong, XJ; Zhang, YF; Zou, K, 2019) |
| "The aim of the study was to investigate the effects of four Aronia melanocarpa-based juices in a rat model of indomethacin-induced gastric ulceration." | 3.91 | Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers. ( Denev, P; Eftimov, M; Georgieva, A; Kuzmanov, A; Kuzmanov, K; Kuzmanova, V; Tzaneva, M; Valcheva-Kuzmanova, S, 2019) |
| "The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats." | 3.88 | Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. ( Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H, 2018) |
| " One of its representative components, the tricyclic triterpenoid β-patchoulone (β-PAE) has demonstrated great anti-inflammatory activity and gastroprotective effect against ethanol-induced gastric injury, but its protective effect against gastric ulcer induced by indomethacin is still unknown." | 3.88 | Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. ( Chen, JN; Dou, YX; Huang, QH; Liang, JL; Liu, YH; Nie, J; Su, ZR; Wu, JZ; Wu, QD; Wu, X; Zhuo, JY, 2018) |
| " The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats." | 3.88 | Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats. ( Gupta, G; Hatware, KV; Karri, S; Patil, K; Sharma, S; Shete, M, 2018) |
| "Severe gastric ulceration induced in rats by administration of indomethacin in combination with cold stress (IND + CS) for 2 h." | 3.88 | Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats. ( Fahmy, SR; Sayed, DA; Soliman, AM, 2018) |
| " Aiming to contribute in the scientific validation about the popular use of Brazilian Green propolis (BGP) against gastritis and gastric ulcer, this work evaluated the antiulcer potential of isolated compounds from BGP, three prenylated p-coumaric acid derivatives and two flavonoids, respectively named: 3,5 diprenyl-4-hydroxycinnamic acid (artepillin C) (1), 3-prenyl-4-dihydroxycinnamoiloxy cinnamic acid (baccharin) (2), 3-prenyl-4-hydroxycinnamic acid (drupanin) (3), aromadendrin-4'-O-methyl-ether (4) and kaempferide (5)." | 3.88 | Artepillin C, drupanin, aromadendrin-4'-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action. ( Almeida, MO; Andrade, SF; Arruda, C; Bastos, JK; Boeing, T; Casoti, R; Costa, P; da Silva, LM; da Silva, RCMVAF; Dos Santos, AC; Lemos, M; Mariott, M; Somensi, LB; Souza, P; Stein, BP, 2018) |
| "This study investigated the gastroprotective effects and the systemic oxidative status of oral kefir pretreatment in albino mice submitted to acute gastric ulcer induced by indomethacin." | 3.88 | Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress. ( Alves, GM; Barboza, KRM; Campagnaro, BP; Coco, LZ; Meyrelles, SS; Pereira, TMC; Peters, B; Vasquez, EC, 2018) |
| "3 M- and indomethacin-induced gastric ulcer were performed in rodents." | 3.88 | Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol. ( Beber, AP; Boeing, T; Burci, LM; Cury, BJ; da Silva, CB; da Silva, LM; de Andrade, SF; de Souza, P; Mariano, LNB; Simionatto, E; Somensi, LB, 2018) |
| " The compounds were evaluated for their anti-inflammatory activity in carrageenan induced rat paw edema model taking rofecoxib and indomethacin as standard drugs." | 3.85 | Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect. ( Bali, A; Chaudhari, BB; Sharma, R, 2017) |
| " The gastroprotective effect of CRG/Ech complexes was investigated on the model of stomach ulcers induced by indomethacin in rats." | 3.85 | Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome. ( Davydova, VN; Glazunov, VP; Kravchenko, AO; Mischchenko, NP; Pimenova, EA; Sorokina, IV; Tarbeeva, DV; Yermak, IM, 2017) |
| ""Unhealed gastric ulcers" were induced using indomethacin following the establishment of acetic-acid-induced chronic gastric ulcers." | 3.85 | Healing and Antisecretory Effects of Aqueous Extract of ( Amang, AP; Emakoua, J; Enow-Orock, GE; Mbah, G; Mezui, C; Nkwengoua, EZ; Siwe, GT; Tan, PV, 2017) |
| " The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats." | 3.85 | Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats. ( Alkushi, AGR; Elsawy, NAM, 2017) |
| "This study investigated the gastroprotective effects of N-acetylcysteine (NAC) against indomethacin-induced gastric ulcer in rats." | 3.85 | N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms. ( Ali, DA; Katary, MA; Soliman, NA; Zineldeen, DH, 2017) |
| " After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days." | 3.85 | Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. ( Eyoum Bille, B; Kouitcheu Mabeku, LB; Nanfack Nana, B; Nguepi, E; Tchuenteu Tchuenguem, R, 2017) |
| " The gastroprotective activity of the OECC was investigated using animal models of gastric ulcer induced by the administration of absolute ethanol, acidified ethanol or indomethacin." | 3.85 | Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice. ( Coutinho, HDM; da Silva Almeida, JRG; de Albuquerque, TR; de Alencar Silva, A; de Menezes, IRA; de Oliveira, MRC; Oliveira Brito Pereira Bezerra Martins, A; Quintans, LJ; Ribeiro-Filho, J; Vidal, CS, 2017) |
| "These findings suggest that ZnCl(2), enhances the gastroprotective activity ofrisperidone in indomethacin- induced gastric ulcer." | 3.83 | Zinc salt enhances gastroprotective activity of risperidone in indomethacin-induced gastric ulcer. ( Oluwole, FS; Onwuchekwa, C, 2016) |
| "The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats." | 3.83 | Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata. ( Garuba, T; Ismail, NO; Sabiu, S; Sulyman, AO; Sunmonu, TO, 2016) |
| "These results indicated that lycopene might have a protective effect against indomethacin-induced gastric ulcer and oxidative stress in rats." | 3.83 | The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats. ( Avci, H; Boyacioglu, M; Epikmen, ET; Karademir, U; Kum, C; Sekkin, S; Yalinkilinc, HS, 2016) |
| " The optimized GR formulation was examined for its protective effect on the gastric ulcer induced by indomethacin in albino rabbits compared with lactose tablets." | 3.83 | Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits. ( Abu Hashim, II; Badria, FA; Mohamed, EA; Yusif, RM, 2016) |
| " The aim was to scientifically evaluate the possible gastroprotective effect and the underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats." | 3.83 | The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. ( Chen, HM; Chen, XY; Fu, LD; Huang, XQ; Lai, XP; Liang, YZ; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Zhang, X; Zhang, ZB; Zheng, YF, 2016) |
| " In this study, we identified PA-rich food sources and examined the effects of the food materials on indomethacin-induced stomach ulcer." | 3.83 | Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer. ( Afroz, S; Ikoma, T; Kogure, K; Tanaka, T; Tokumura, A; Yagi, A, 2016) |
| " Models of acute gastric ulcer induction by ethanol and indomethacin and of chronic ulcer by acetic acid were used." | 3.81 | Antiulcerogenic activity of Carica papaya seed in rats. ( Argadoña, EJ; Cardoso, CA; Carollo, CA; Carrasco, V; Cordeiro, KW; Freitas, Kde C; Pinto, LA, 2015) |
| "This study investigated the protective effects of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats." | 3.81 | Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats. ( Gomathy, G; Palani, S; Venkatesan, D, 2015) |
| " Six scoparone derivatives were synthesized and screened for gastroprotective activities against HCl/ethanol- and indomethacin-induced gastric ulcers in rats." | 3.81 | Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents. ( Choi, WS; Lee, GR; Lee, SE; Oh, S; Son, DJ, 2015) |
| " This study investigated the anti-ulcerogenic and antioxidant activities of aqueous extract of Carica papaya seed against indomethacin-induced peptic ulcer in male rats." | 3.81 | Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. ( Adaja, MC; Ajiboye, TO; Oloyede, HO; Salawu, MO, 2015) |
| " However, there is no report on the gastroprotective effect of ASB against indomethacin-induced gastric ulcer." | 3.81 | Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats. ( Chen, HM; Chen, XY; Feng, XX; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Yu, XT; Zeng, HF; Zhang, X; Zhang, ZB; Zheng, YF, 2015) |
| " Antiulcerogenic activity of AcE-NP was also evaluated with an acute gastric ulcer experimental model induced by ethanol and indomethacin." | 3.81 | Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity. ( de Carvalho, JE; Foglio, MA; González-Gómez, A; Jorge, MP; Monteiro, KM; Queiroz, Nde C; Reyes-Ortega, F; San Román, J; Servat-Medina, L; Sousa, IM; Zago, PM, 2015) |
| " In contrary, a clinical report indicated the formation of gastric ulcer by the use of atorvastatin." | 3.81 | Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS. ( Atukeren, P; Gümüştaş, K; Gürel, A; Özdemir, O; Özyoğurtçu, H; Uyanik, Ö; Uydeş-Doğan, S; Yildirim, FI, 2015) |
| " Treatment with MESe also decreased gastric ulceration induced by indomethacin." | 3.81 | Gastroprotective bio-guiding study of fruits from Mimusops balata. ( Boeing, T; Bordignon Somensi, L; de Moura Burci, L; Faloni de Andrade, S; Filho, VC; Mota da Silva, L; Santin, JR; Schlickmann, F, 2015) |
| " All the compounds were evaluated for their anti-inflammatory (carrageenan-induced rat paw edema assay), antioxidant (inhibition of lipid peroxidation) and antiulcer activity (indomethacin-induced gastric damage)." | 3.81 | Synthesis, Structure Activity Relationship (SAR), and Biological Activities of Benzylideneacetophenones Derivatives. ( Choudhary, AN; Juyal, V; Kumar, A, 2015) |
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 3.80 | 1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2014) |
| "To investigate the protective effect of DHEA on indomethacin-induced gastric ulcers in rats." | 3.80 | The impact of dehydroepiandrosterone on indomethacin-induced gastric lesions in rats. ( Alessa, R; Alkhateeb, M; Bayoumy, NM; Bin-Jaliah, I; Eleawa, S; Sakr, HF, 2014) |
| "The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats." | 3.80 | Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats. ( Agastian, P; Antonisamy, P; Balthazar, JD; Dhanasekaran, M; Duraipandiyan, V; Ignacimuthu, S; Kim, JH, 2014) |
| " In the present work, we evaluated the healing effect of L-theanine on NSAID (indomethacin)-induced gastric ulcer." | 3.80 | L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin. ( Bandyopadhyay, SK; Bera, B; Chatterjee, A; Chatterjee, S; Roy, S, 2014) |
| " This study investigated the possible mechanisms underlying the gastroprotective effect of escin against indomethacin-induced gastric ulcer in mice." | 3.80 | Protective effects of escin against indomethacin-induced gastric ulcer in mice. ( Chu, L; Du, H; Fu, F; Wang, T; Wang, Y; Yang, Y; Yao, L; Zhao, S, 2014) |
| " For this study, an indomethacin-induced gastric ulcer rat model was used." | 3.80 | Gastroprotective activity of violacein isolated from Chromobacterium violaceum on indomethacin-induced gastric lesions in rats: investigation of potential mechanisms of action. ( Al-Dhabi, NA; Antonisamy, P; Arasu, MV; Aravinthan, A; Duraipandiyan, V; Ignacimuthu, S; Kannan, P; Kim, JH, 2014) |
| " This study aimed to investigate the possible anti-ulcerogenic potential of PA and the underlying mechanism against ethanol, indomethacin and water immersion restraint-induced gastric ulcers in rats." | 3.80 | Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats. ( Chen, XY; Huang, P; Jiang, WW; Liang, YZ; Liu, YH; Mo, ZZ; Su, ZR; Xie, JH; Xu, YF; Yu, XD; Zheng, YF, 2014) |
| " The gastrointestinal injury was accompanied by signs of chronic stress: long-lasting increase in corticosterone blood level, adrenal hypertrophy, thymus involution, and loss of body weight." | 3.80 | [Somatic pain sensitivity under indometacin induced gastric and small intestinal injury in rats]. ( Bagaeva, TR; Filaretova, LP; Iarushkina, NI, 2014) |
| "Gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg)." | 3.79 | Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats. ( El-Moselhy, MA; Morsy, MA, 2013) |
| "The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model." | 3.79 | Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice. ( Acharya, K; Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Khatua, S; Mukherjee, A; Mukherjee, S; Paloi, S, 2013) |
| " The anti-inflammatory activity of 1a-h was investigated by acute carrageenan-induced paw edema in mice using the reference drug indomethacin." | 3.79 | Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties. ( Al-Tabakha, MM; Caproiu, MT; Fahelelbom, KM; Limban, C; Missir, AV; Sadek, B, 2013) |
| " The gastroprotective action of ME was analyzed in gastric ulcers that were induced by ethanol or indomethacin in Wistar male rats." | 3.79 | Effect of menthol in experimentally induced ulcers: pathways of gastroprotection. ( Hiruma-Lima, CA; Padovani, CR; Pellizzon, CH; Rozza, AL; Takahira, RK, 2013) |
| " However, the gastroprotective effect of chronic stress was not manifested and there was no aggravation of indomethacin-induced gastric ulceration, either." | 3.79 | Does chronic stress enhance the risk of diseases? ( Filaretova, L; Laszlo, F; Morozova, O; Morschl, E; Zelena, D, 2013) |
| " The gastroprotective effect of HAE was demonstrated on the indomethacin-induced gastric ulcer model after the administration of extracts." | 3.79 | Protective effect of Chresta martii extract against indomethacin-induced gastric lesions in mice. ( Abbet, C; Aguiar, JA; Bezerra, MM; Chaves, HV; Franco, ES; Henriques, AT; Hostettmann, K; Maia, MB; Pereira, KM; Pinto, VP; Silva, AA; Simões-Pires, CA, 2013) |
| "A series of 3-alkoxy-4-methanesulfonamido acetophenone derivatives were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model." | 3.78 | Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents. ( Bali, A; Deb, PK; Ohri, R, 2012) |
| " Gastric ulceration was induced by indomethacin, scored, and assayed to determine the concentration of mucus, malondialdehyde, catalase, and superoxide dismutase in homogenized samples." | 3.78 | The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat. ( Ajeigbe, K; Asuk, A; Emikpe, B; Oladejo, E; Olaleye, S, 2012) |
| " amara) and its bioactive principles-quassin and 2-methoxycanthin-6-one on gastric ulceration were studied in albino rats." | 3.78 | Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats. ( Oloyede, GK; Raji, Y, 2012) |
| " The oral administration of the Chantaleela recipe reduced ulcer formation in acute gastric ulcer models (EtOH/HCl-, indomethacin-, and stress-induced gastric lesions)." | 3.78 | Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe. ( Jaijoy, K; Khonsung, P; Nanna, U; Piyabhan, P; Sireeratawong, S; Soonthornchareonnon, N, 2012) |
| "The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats." | 3.78 | Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. ( Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M, 2012) |
| "We examined the molecular mechanism of curcumin in a preventive and therapeutic model of indomethacin-induced gastric ulceration with regard to angiogenic processes." | 3.78 | Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling. ( Ganguly, K; Maulik, N; Paul, S; Sharma, AV; Swarnakar, S, 2012) |
| "The pharmacokinetics of ϵ-acetamidocaproic acid (AACA) were evaluated after the intravenous and oral administration of an antiulcer agent, zinc acexamate (ZAC) at a dose of 20 mg kg⁻¹ (ion pairing between zinc and AACA) in rats with indomethacin-induced acute gastric ulcer (IAGU) or indomethacin-induced small bowel inflammation (ISBI)." | 3.78 | ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation. ( Choi, YH; Kim, YG; Lee, BK; Lee, MG; Lee, U; Oh, E, 2012) |
| "Zerumbone (1) showed potent cytoprotective effect against necrotizing agent (HCl) and non-steroidal anti-inflammatory drug (indomethacin) induced gastric ulceration." | 3.78 | Antiulcer principle from Zingiber montanum. ( Al-Amin, M; Hossain, CF; Sultana, GN, 2012) |
| "The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP)." | 3.78 | Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity. ( Abdul Hisam, EE; Hasiah, AH; Norhafizah, M; Othman, F; Rofiee, MS; Vasudevan, M; Zakaria, ZA, 2012) |
| " In all models, URB937 was as effective or more effective than standard analgesic and anti-inflammatory drugs (indomethacin, gabapentin, dexamethasone) and reversed pain-related responses (mechanical hyperalgesia, thermal hyperalgesia, and mechanical allodynia) in a dose-dependent manner." | 3.78 | Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. ( Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R, 2012) |
| "BI prevented the gastric ulceration caused by ethanol and indomethacin treatments." | 3.78 | Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb. ( Bonaldo, J; Dall'oglio, EL; de Sousa Júnior, PT; Gazoni, VF; Lemos, LM; Martins, DT; Martins, TB; Silva, MG; Strada, CL; Tanajura, GH, 2012) |
| "This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer." | 3.78 | Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. ( Arcanjo Moura, B; Barbosa Filho, JM; de Almeida Leal, LK; de Barros Viana, GS; de Castro Brito, GA; dos Santos e Silva, G; Fragoso de Freitas, AP; Lopes Souto, A; Rios Vasconcelos, E; Santos Cerqueira, G; Silveira Macedo, D; Souccar, C, 2012) |
| "The gastroprotective action of synthetic dipeptides glutamyl-tryptophane (EW), iso-valeroyl-glutamyl-tryptophane (ivEW) and nicotinoyl-glutamyl-tryptophane (nEW) in comparison to melatonin was studied in experiments on male with the model indometacine and starvation stress-induced stomach ulcers." | 3.78 | [Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin]. ( Malinin, VV; Savateeva-Liubimova, TN; Sivak, KV, 2012) |
| "The mechanism of indomethacin-induced gastric ulcer healing by ellagic acid (EA) in experimental mice model is described in our study." | 3.78 | Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. ( Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A, 2012) |
| "The preventive and healing properties of Croton urucurana bark methanol extract (CUE) were evaluated in experimental models of acute (ethanol and indomethacin) and chronic (acetic acid) gastric ulcers." | 3.78 | Antiulcerogenic effect of Croton urucurana Baillon bark. ( Aparecida Pinto, L; de Cássia Freitas, K; Faloni de Andrade, S; Leite Kassuya, CA; Nazari Formagio, AS; Wolff Cordeiro, K, 2012) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 3.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| " Hence, the potential of a new water-soluble GPx mimic, DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) in healing the indomethacin-induced stomach ulceration in mice was examined." | 3.78 | DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) accelerates healing of indomethacin-induced stomach ulceration in mice. ( Chakraborty, S; Chattopadhyay, S; Iwaoka, M; Priyadarsini, KI; Subramanian, M; Yadav, SK, 2012) |
| "This study reports a pharmacological evaluation of anti-inflammatory and anti-ulcer activities of carvacrol, a phenolic monoterpene constituent of essential oils produced by oregano and other several aromatic plants and spices, in experimental models of edema induced by different phlogistic agents and gastric lesions induced by acetic acid." | 3.78 | Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano. ( Arcanjo, DD; Guimarães, AG; Machado, FD; Oliveira, FA; Oliveira, RC; Quintans-Júnior, LJ; Silva, ER; Silva, FV; Sousa-Neto, BP, 2012) |
| " They were subjected to the absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation assays after 30 min." | 3.78 | Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. ( Hamid, HA; Hisam, EE; Mohtaruddin, N; Othman, F; Rofiee, MS; Zakaria, ZA, 2012) |
| "9% for indomethacin-induced acute gastric ulcer (IAGU) rats, respectively] than those of ZAC alone due to the significantly slower renal clearance (CL(R))." | 3.77 | Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. ( Choi, YH; Kim, YG; Lee, M; Lee, MG; Lee, U; Oh, E; Suh, JH, 2011) |
| " Diabetes was induced in rats by a single dose of streptozotocin (STZ) followed by gastric ulceration using indomethacin, and melatonin's action was studied by its application prior to indomethacin exposure." | 3.77 | Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. ( Pradeepkumar Singh, L; Swarnakar, S; Vivek Sharma, A, 2011) |
| "The modulation of the cyclooxygenase-independent pathway by black tea (BT) and its constituent theaflavins (TFs) during their healing action against indomethacin-induced stomach ulceration in mice was investigated." | 3.77 | Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing. ( Adhikary, B; Bandyopadhyay, SK; Chand, S; Chattopadhyay, S; Yadav, SK, 2011) |
| " Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice." | 3.77 | Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011) |
| "To study the effect of aqueous propolis extract (AEP) against indomethacin (Indo)-induced gastric ulcers in irradiated and non-irradiated rats." | 3.77 | Anti-ulcerogenic effect of aqueous propolis extract and the influence of radiation exposure. ( El-Ghazaly, MA; Khayyal, MT; Rashed, RR, 2011) |
| " Acute gastric ulcer was induced using absolute ethanol, HCl/ethanol and indomethacin." | 3.77 | Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae). ( Caldas, GF; da Costa, JG; da Nóbrega, RF; da Silva, JB; do Amaral Costa, IM; Rodrigues, FF; Wanderley, AG, 2011) |
| "5]undecan-8-oxyl (compound 1) and 4-oxo-2,2,6,6-tetraethylpiperidine-1-oxyl (compound 2) in the prevention of gastric ulcers in adjuvant arthritis rats treated with indomethacin was evaluated by monitoring the reaction of reactive oxygen species in gastric tissue with Overhauser-enhanced magnetic resonance imaging (OMRI)." | 3.77 | Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats. ( Deguchi, H; Ichikawa, K; Kinoshita, Y; Mito, F; Naganuma, T; Sakai, K; Sato, S; Utsumi, H; Yamada, K; Yamasaki, T; Yamato, M; Yasukawa, K, 2011) |
| "The gastro-protective and antioxidant effects of methanol extract of Ficus asperifolia bark on indomethacin induced gastric ulcer were investigated in male rats." | 3.77 | Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats. ( Bolarinwa, AF; Oyeyemi, WA; Raji, Y; Shittu, ST, 2011) |
| " The present study was conducted to test for the possible gastroprotective effect of nicotinamide utilizing an acute indomethacin-induced gastric ulcer model." | 3.76 | Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent. ( Abdallah, DM, 2010) |
| "Acute gastric ulcers were induced in rats by the oral administration of indomethacin." | 3.76 | The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage. ( Fujisawa, M; Hori, M; Murata, T; Ozaki, H, 2010) |
| "To evaluate, for the first time, the efficacy of copper-indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial oxidative damage, and renal toxicity in rat models." | 3.76 | Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. ( Bonin, AM; Davies, NM; Dillon, CT; Fukuda, C; Hambley, TW; Lay, PA; Teng, XW; Yáñez, JA, 2010) |
| "Gastric ulcers were induced in mice with a single dose of indomethacin." | 3.76 | Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine. ( Bandyopadhyay, SK; Chatterjee, A; Chattopadhyay, S; Dey, A; Guha, P, 2010) |
| "The protective effects of telmisartan, the angiotensin II-receptor antagonist, were investigated in rats with type 2 diabetes mellitus exposed to acute gastric ulceration." | 3.76 | Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. ( Al-Sultan, AI; Fouad, AA; Gomaa, W; Yacoubi, MT, 2010) |
| "The aim of the study was to evaluate the antiulcer activity of Linum usitatissimum fixed oil against aspirin-, indomethacin-, ethanol-, reserpine-, serotonin- and stress-induced gastric ulceration in rats and histamine-induced gastric ulceration in guinea pigs." | 3.76 | Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action. ( Kaithwas, G; Majumdar, DK, 2010) |
| " We reported previously that melatonin (N-acetyl-5-methoxy tryptamine), an antioxidant and anti-inflammatory agent, prevents indomethacin-induced gastric ulcers." | 3.76 | Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. ( Ganguly, K; Reiter, RJ; Sharma, AV; Swarnakar, S, 2010) |
| "The aim of this work was to study the ability of beta-cyclodextrin (beta-CD) or hydroxypropyl beta-cyclodextrin (HP-beta-CD) to ameliorate the induction of gastric ulcers by a nonsteroidal anti-inflammatory drug, indomethacin or piroxicam, in rats exposed to restraint and hypothermic stress at 4 degrees C." | 3.76 | Influence of cyclodextrin complexation with NSAIDs on NSAID/cold stress-induced gastric ulceration in rats. ( Ahmed, MO; Alanazi, FK; Alsarra, IA; Alsheikh, AM; Eltahir, KE; Neau, SH, 2010) |
| ") significantly decreased ethanol- and indomethacin-induced gastric ulcer compared with the vehicle-treated (control) group." | 3.76 | Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. ( Hara, H; Kakino, M; Ogawa, K; Oyagi, A, 2010) |
| "5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats." | 3.76 | Anti-ulcer and antioxidant activity of GutGard. ( Agarwal, A; Allan, JJ; Bhaskaran, N; Mukherjee, M; Shekhar, D; Shivaprasad, HN; Srinath, R, 2010) |
| "The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model." | 3.76 | Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G, 2010) |
| " Results showed that 1-acylated-5-amino-1,2,4-triazole-3-acetates 3a-e showed higher anti-inflammatory activity than the corresponding 5-acylamino derivatives 4a-e in carageenan-induced rat paw edema test with low gastric ulcerogenicity compared with indomethacin." | 3.75 | Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity. ( Abdel-Megeed, AM; Abdel-Rahman, HM; Alkaramany, GE; El-Gendy, MA, 2009) |
| " The prepared compounds were evaluated for their anti-inflammatory activity using carrageenan-induced rat paw edema and compared to a well-known NSAID, indomethacin as a reference drug." | 3.75 | Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives. ( Abdel-Aziz, M; Aly, OM; Farag, HH; Morsy, MA; Shoman, ME, 2009) |
| " The combined anti-inflammatory data from in vitro animal model showed that compounds, 9,11-dibromo-1-(2-furyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 23, 9,11-dibromo-1-(4-methoxy-phenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 24, 9,11-dibromo-1-(4-chloro-phenyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 29 and 9-bromo-1-(4-chloro-phenyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 36 exhibited even more potent anti-inflammatory activity and low gastric ulceration incidence compare to reference standard Indomethacin." | 3.75 | A new therapeutic approach in Parkinson's disease: some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents. ( Bhatnagar, SP; Laddha, SS, 2009) |
| "Leaf fractions of Wilbrandia ebracteata were investigated for anti-ulcerogenic effects in ethanol and indomethacin-induced gastric ulcer assays in mice." | 3.75 | Gastric anti-ulcer activity of leaf fractions obtained of polar extract from Wilbrandia ebracteata in mice. ( Coelho, RG; Di Stasi, LC; Gonzalez, FG; Sannomiya, M; Vilegas, W, 2009) |
| "Despite its potential, use of trans-resveratrol as an anticancer drug is severely constrained because of its tendency to prolong gastric ulceration." | 3.75 | Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice. ( Bandyopadhyay, SK; Chattopadhyay, S; Dey, A; Dhyani, MV; Guha, P; Sarkar, B, 2009) |
| "This study investigated the possible mechanisms underlying the gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats." | 3.75 | Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. ( Amin, RS; Hassan, MK; Heeba, GH, 2009) |
| "The role of the arginine-metabolism in the healing action of the Myristica malabarica phenol malabaricone B (mal B) and omeprazole against indomethacin-induced stomach ulceration in mouse was investigated." | 3.75 | Regulation of arginase/nitric oxide synthesis axis via cytokine balance contributes to the healing action of malabaricone B against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B, 2009) |
| "We conclude that ATL-313 does not inhibit the mucosal damaging effect of indomethacin, but it does block secondary injury due to stomach inflammation." | 3.75 | Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. ( Jin, M; Koizumi, S; Linden, J; Odashima, M; Ohnishi, H; Otaka, M; Watanabe, S, 2009) |
| "Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice." | 3.75 | Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. ( Bandyopadhyay, SK; Chattopadhyay, S; Dey, A; Guha, P, 2009) |
| " polium) in indomethacin-induced gastric ulcer in rats." | 3.75 | The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats. ( Amini, M; Azarpira, N; Fattahi, MR; Mehrabani, D; Panjehshahin, MR; Rezaee, A; Saberi-Firouzi, M; Tanideh, N, 2009) |
| " For this study, ethanol- and indomethacin-induced gastric ulcer models in mice and histopathological assessment were used." | 3.75 | Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action. ( de Carvalho, AM; de Sousa, DP; de Sousa, FC; Macêdo, DS; Moura, BA; Neto, MR; Rocha, NF; Silva, MI; Tomé, Ada R; Vasconcelos, SM; Viana, GS, 2009) |
| " The analgesic activity of the test compounds was determined by phenylbenzoquinone-induced writhing assay and the anti-inflammatory activity was evaluated by the carrageenan-induced rat paw edema model." | 3.75 | Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives. ( Colak, MS; Gökçe, M; Küpeli, E; Sahin, MF, 2009) |
| "Telmisartan is an angiotensin II T1 receptor blocker (ARB) with partial peroxisome proliferator-activated receptor gamma (PPARgamma) agonistic properties; two actions that are suggested to be efficacious for protecting against gastric ulcers." | 3.75 | Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats. ( Amin, E; Ashour, O; Morsy, M; Rofaeil, R, 2009) |
| "To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers." | 3.75 | EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009) |
| "Studies were performed in two different models (ethanol and indomethacin induced gastric ulcer) in wistar rats." | 3.74 | Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models. ( Arun, M; Asha, VV, 2008) |
| "Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin are widely used in the treatment of inflammation, fever and pain." | 3.74 | Beneficial effects of vegetable oils (corn, olive and sunflower oils) and alpha-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats. ( Atalay, F; Aygun, H; Cadirci, E; Cakir, A; Halici, M; Halici, Z; Odabasoglu, F; Suleyman, H, 2008) |
| " The results revealed that 100 mg/kg nimesulide produces gastric ulceration in adrenalectomized rats, which is prevented by prednisolone and adrenaline." | 3.74 | Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats. ( Cadirci, E; Gocer, F; Hacimuftuoglu, A; Halici, Z; Keles, S; Suleyman, H, 2007) |
| " The results of ulcerogenic studies indicate that the gastric ulcerogenecity of plant extract is lower than the indomethacin in the rat's stomach." | 3.74 | The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. ( Heidari, MR; Khazaeli, P; Mehrabani, M; Pardakhty, A; Vahedian, M; Yakhchali, M; Zahedi, MJ, 2007) |
| " In the present study, we examined the effect of alendronate on the healing of acetic acid-induced gastric ulcers in rats and investigated the mechanism involved in this action both in vivo and in vitro using the rat gastric epithelial cell line (RGM1)." | 3.74 | Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. ( Aihara, E; Amagase, K; Hayashi, S; Nishikawa, K; Takeuchi, K, 2007) |
| "The effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) on gastric secretion and gastric cytoprotection was evaluated using five different models of gastric ulcers: acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol-induced, indomethacin-induced and ischemia-reperfusion-induced gastric ulcers." | 3.74 | Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats. ( Asad, M; Hrishikeshavan, HJ; Pathak, R; Prasad, S, 2007) |
| " The effect of orally administered SIM was also studied on indomethacin- and ethanol-induced gastric ulcers." | 3.74 | Gastric antisecretory and antiulcer effects of simvastatin in rats. ( Al Moutaery, M; Al Rayes, H; Al Swailam, R; Arshaduddin, M; Elfaki, I; Khan, HA; Tariq, M, 2007) |
| "APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties." | 3.74 | Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Bhattacharya, S; Chattopadhyay, S, 2007) |
| " This study was designed to evaluate its gastroprotective effects on ethanol/HCl, indomethacin and pylorus ligation-induced gastric ulcers in rats." | 3.74 | Cytoprotective effects of Bergenia ciliata Sternb, extract on gastric ulcer in rats. ( Gulfraz, M; Kakub, G, 2007) |
| "The healing activity of the methanol extract of the spice rampatri, Myristica malabarica, (RM) and omeprazole against indometacin-induced stomach ulceration has been studied in a mouse model." | 3.74 | Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Maity, B, 2007) |
| "The healing activity of malabaricone B and malabaricone C, the major antioxidant constituents of the spice Myristica malabarica against the indomethacin-induced gastric ulceration in mice has been studied." | 3.74 | Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK, 2008) |
| "To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model." | 3.74 | The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. ( Atamanalap, SS; Aydinli, B; Başoğlu, M; Gündoğdu, C; Gürsan, N; Kiziltunç, A; Oren, D; Oztürk, G; Polat, KY; Süleyman, H; Yildirgan, MI, 2007) |
| "The drugs, mal B and mal C could effectively heal indomethacin-induced stomach ulceration in mice by promoting angiogenesis." | 3.74 | Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration. ( Bandivdeker, AH; Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B, 2008) |
| "The present study was undertaken to evaluate the potential of the rhizomes of the Indian medicinal plant, Picrorhiza kurroa in healing indomethacin-induced acute stomach ulceration in mice and examine its capacity to modulate oxidative stress and the levels of prostaglandin (PGE2) and EGF during the process." | 3.74 | Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B; Nag, SK, 2008) |
| "Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels." | 3.74 | Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S, 2008) |
| " However, the role of MMPs in indomethacin-induced gastric ulcer and its healing process are not clearly understood." | 3.73 | Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. ( Banerjee, A; Ganguly, K; Kundu, P; Maity, P; Sharma, AV; Swarnakar, S, 2005) |
| "The present study was aimed to evaluate the effect of licofelone, a dual inhibitor of cycloxygenase1/2-5-lipoxygenase against indomethacin-induced gastric damage in rats and mice in order to assess the role of leukotrienes if any, in non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal inflammation." | 3.73 | Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation. ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| " Since compounds with cytoprotective and antioxidant effects can improve healing of gastroduodenal ulcer induced by noxious agents, this work investigated the healing effect of D- 002 on acute and chronic gastric ulcers induced with indomethacin and acetic acid, respectively, in rats." | 3.73 | Therapeutic effect of D-002 (abexol) on gastric ulcer induced experimentally in rats. ( Arruzazabala, L; Carbajal, D; Más, R; Molina, V, 2005) |
| " pylori-associated indomethacin-induced gastric ulcers in rats." | 3.73 | Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa. ( Arend, A; Aunapuu, M; Loime, L; Lõivukene, K; Roosaar, P; Selstam, G; Sepp, E; Soom, M; Zilmer, K; Zilmer, M, 2005) |
| "Reactive oxygen species (ROS) are thought to be involved in the gastric ulcer formation induced by indomethacin, a typical nonsteroidal anti-inflammatory drug." | 3.73 | Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats. ( Shigemi, R; Soeda, T; Tsuneyoshi, M; Utsumi, H; Yamada, K; Yao, T; Yasukawa, K, 2006) |
| "We have investigated the mechanism of indomethacin-induced gastric ulcer caused by reactive oxygen species (ROS) and the gastroprotective effect of curcumin thereon." | 3.73 | Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. ( Bandyopadhyay, U; Banerjee, RK; Biswas, K; Chattopadhyay, I; Maity, P, 2006) |
| "The first patient with chronic paroxysmal hemicrania has been followed for 45 years, and for 33 years with indomethacin treatment." | 3.73 | Chronic paroxysmal hemicrania, hemicrania continua and SUNCT: the fate of the three first described cases. ( Sjaastad, O, 2006) |
| "To study the effects of amphetamine, an indirect-acting adrenomimetic compound on the indomethacin-induced gastric ulcerations in rats." | 3.73 | Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats. ( Birt, MA; Cuparencu, B; Dumitrascu, DL; Krausz, TL; Sandor, V, 2006) |
| " (methanolic extract) and its action against indomethacin (a non-steroidal anti-inflammatory drug) plus pyloric ligation (PL)-induced gastric ulcers in rats." | 3.73 | Antisecretory and antiulcer activity of Asparagus racemosus Willd. against indomethacin plus phyloric ligation-induced gastric ulcer in rats. ( Bhatnagar, M; Sisodia, SS, 2006) |
| " L-carnitine significantly prevented gastric ulcerogenesis induced by indomethacin and decreased the ulcer index macroscopically and histopathologically." | 3.73 | Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study. ( Altaner, S; Dokmeci, D; Erkin, B; Turan, FN, 2006) |
| "The effects of beta-cyclodextrin (betaCD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied." | 3.72 | Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin. ( Almeida, AB; Brito, AR; De Azevedo, MB; Durán, N; Haun, M; Justo, GZ; Melo, PS, 2003) |
| " The carrageenan-induced paw edema, cotton pellet granuloma and indomethacin-induced gastric damage models were used to determine these effects." | 3.72 | Anti-inflammatory and antiulcerogenic effects of the aqueous extract of Lobaria pulmonaria (L.) Hoffm. ( Aslan, A; Bayir, Y; Cakir, A; Gocer, F; Halici, M; Karagoz, Y; Odabasoglu, F; Süleyman, H, 2003) |
| "We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation." | 3.72 | Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003) |
| "This investigation was undertaken to study the effect of methimazole (MMI) on gastric acid secretion and stress and chemically induced gastric ulcer in rats." | 3.72 | Methimazole prevents stress and chemical induced gastropathy in rats. ( Al Moutaery, A, 2003) |
| "Effects of glucocorticoid deficiency followed by corticosterone replacement on the healing of gastric erosions and chronic gastric ulcers have been investigated in rats." | 3.72 | [Deficiency of glucocorticoid production delays the healing of acute gastric mucosal erosion and chronic ulcers in rats]. ( Bagaeva, TR; Filaretova, LP; Morozova, OIu; Podvigina, TT, 2003) |
| "The effects of an aqueous root extract from Rumex patientia (D-1) compared to COX-2 selective inhibitors on indomethacine and ethanol induced stomach ulcers were investigated." | 3.72 | Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats. ( Demirezer, LO; Kuruüzüm-Uz, A; Süleyman, H, 2004) |
| " Four compounds were proved to be as active as indomethacin in animal models of inflammation." | 3.72 | Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents. ( Aboulmagd, E; Bekhit, AA; El-Sayed, OA; Park, JY, 2004) |
| " In the present study, we examined the effect of various COX inhibitors on gastric ulcerogenic and acid secretory responses following daily exposure of the stomach to iodoacetamide (IA) and investigated the role for COX isozyme in gastric protection under subchronic mucosal irritation." | 3.72 | Roles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach. ( Hayashi, Y; Murakami, M; Takeeda, M; Takeuchi, K; Yamato, M, 2004) |
| " We examined the roles of TNF-alpha and dynamics of chemokine expression in gastric ulceration including ulcer recurrence and indomethacin-induced injury." | 3.72 | Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha. ( Arakawa, T; Fujiwara, Y; Hamaguchi, M; Higuchi, K; Matsumoto, T; Shiba, M; Tominaga, K; Watanabe, T, 2004) |
| "The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours)." | 3.72 | Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin. ( Antônio, MA; Bighetti, AE; Carvalho, JE; Rosaneli, CF; Sgarbieri, VC, 2004) |
| " Concerning the gastric effects, lavender oil, linalool and linalyl acetate oral administration protected against acute ethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade." | 3.72 | Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil. ( Ballabeni, V; Barocelli, E; Bianchi, A; Bruni, R; Calcina, F; Chiavarini, M; Impicciatore, M, 2004) |
| ") Dubard, have been studied on ethanol, ethanol-indomethacin and pylorus ligated gastric ulcers in experimental animals." | 3.72 | Effect of Manilkara hexandra (Roxb.) Dubard against experimentally-induced gastric ulcers. ( Goswami, SS; Santani, DD; Shah, MB, 2004) |
| "The effects of intracerebroventricular (icv) or subcutaneous (sc) hexarelin (Hexa) administration, against gastric ulcers induced by ethanol (50%, 1 ml/rat/os) or Indomethacin (20 mg/kg/os) were examined in conscious rats." | 3.72 | Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat. ( Bulgarelli, I; Guidobono, F; Lattuada, N; Locatelli, V; Netti, C; Pagani, F; Rapetti, D; Sibilia, V; Torsello, A, 2004) |
| "The acetone soluble fraction from a crude methanol extract of Stryphnodendron adstringens stem bark (AFSAB) was evaluated in acute (ethanol, indomethacin and hypothermic restraint-stress) and chronic (acetic acid) models of gastric ulceration and on basal and bethanechol-stimulated gastric acid secretion in rats." | 3.71 | The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats. ( Lima, JC; Martins, DT; Rao, VS, 2002) |
| " Pre-treatment with the extract (100, 200 and 400 mg/kg) produced a significant and dose-dependent inhibition to the acute gastric ulcers induced by phenylbutazone, indomethacin, 0." | 3.71 | Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats. ( Al-Attas, A; Chan, K; Chen, HB; Islam, MW; Ismail, A; Liu, XM; Radhakrishnan, R; Zakaria, MN, 2001) |
| " The acute gastric ulcer models used were pylorus ligation, indomethacin-induced and ethanol-induced gastric ulcers." | 3.71 | Effect of centrally administered prolactin on gastric and duodenal ulcers in rats. ( Abraham, BK; Asad, M; Koumaravelou, K; Ramaswamy, S; Shewade, DG; Vasu, S, 2001) |
| "The effects of a nitric oxide (NO) releasing derivative of indomethacin (NCX-530) on gastric ulcerogenic and healing responses were evaluated in rats and mice, in comparison with the parent compound indomethacin." | 3.71 | Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals. ( Araki, H; Komoike, Y; Mizoguchi, H; Suzuki, K; Takeuchi, K, 2001) |
| "We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism." | 3.71 | Effects of diacerein on indomethacin-induced gastric ulceration. ( Ohmori, K; Tamura, T; Yokoyama, T, 2001) |
| "Celecoxib and indometacin both decreased the epithelial proliferative response and delayed healing of cryoprobe-induced gastric ulcers." | 3.71 | Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats. ( Bjarnason, I; Caldwell, C; Palmer, RH; Sigthorsson, G; Tibble, J, 2001) |
| " The acute gastric ulcer models used were pylorus ligation, indomethacin, ethanol and histamine induced acute gastric ulcers." | 3.71 | Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. ( Abraham, BK; Asad, M; Koumaravelou, K; Ramaswamy, S; Shewade, DG; Vasu, S, 2001) |
| " The TFF2-deficient mice also showed a significant increase in the degree of gastric ulceration after administration of indomethacin." | 3.71 | TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. ( Chen, D; Farrell, JJ; Koh, TJ; Podolsky, DK; Taupin, D; Wang, TC; Zhao, CM, 2002) |
| "Osmolality changes evoked with intragastric administration of natural honey or mannitol, significantly decreased the gastric ulceration of rats induced by indomethacin." | 3.71 | The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat. ( Balint, GA; Galfi, M; Gharzouli, K; Juhasz, A; Rimanoczy, A, 2001) |
| " In the present study, we investigated the protective effects of these compounds against gastric ulcers induced by acidified ethanol (AE) and indomethacin." | 3.71 | A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat. ( Bastaki, SM; Chandranath, SI; Singh, J, 2002) |
| " pylori infection, indomethacin, and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed gastric ulcers in Mongolian gerbils." | 3.71 | Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils. ( Ebata, M; Keto, Y; Okabe, S; Tomita, K, 2002) |
| "The traditional Chinese medicine Shundao Granules po markedly inhibited the formation of gastric ulcers induced by indomethacin, restraint and pyloric ligatin in rats." | 3.70 | [Pharmacological studies of shundao granules on gastrointestinal track]. ( Gu, W; Huang, C; Li, S; Yao, Y, 1998) |
| "trans-Dehydrocrotonin (DHC), the major diterpene isolated from Croton cajucara Benth, was assayed for antiulcerogenic activity in four induced gastric ulcer models in the rat." | 3.70 | Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara. ( Brito, AR; Haun, M; Hiruma-Lima, CA; Nunes, DS; Rodríguez, JA, 1998) |
| " Inhibition of prostaglandin synthesis by traditional NSAIDs such as indomethacin and diclofenac which non-selectively inhibit both PGHS-1 and PGHS-2, causes gastric and intestinal ulceration and delays gastric ulcer healing in chronic models." | 3.70 | Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. ( Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T, 1998) |
| " In this study, we examined whether this antichemotactic factor as well as chemotactic factors are involved in the indomethacin-induced delayed healing of experimental gastric ulcers." | 3.70 | Mechanism by which indomethacin delays the healing of acetic acid-induced ulcers in rats. Role of neutrophil antichemotactic and chemotactic activities. ( Fujita, H; Okabe, S; Takahashi, S, 1998) |
| "To elucidate the role of cyclooxygenase (COX)-2 in ulcer healing, we compared the effects of NS-398 (COX-2-selective inhibitor) and indomethacin (nonselective COX inhibitor) on the healing of acetic acid-induced gastric ulcers in rats." | 3.70 | Role of cyclooxygenase-2 in the healing of gastric ulcers in rats. ( Okabe, S; Shigeta, J; Takahashi, S, 1998) |
| "Effects of selective cyclooxygenase-2 (COX-2) inhibitors (NS-398) and nitric oxide (NO) -releasing aspirin (NO-ASA) on gastric ulcerogenic and healing responses were examined in comparison with nonselective COX inhibitors such as indomethacin and aspirin (ASA)." | 3.70 | Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach. ( Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1998) |
| " at an effective anti-inflammatory dose to rats with pre-existing acetic acid-induced gastric ulcer, NS-398 caused a statistically significant delay of ulcer healing." | 3.70 | Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats. ( Dyer, RD; Gilbertsen, RB; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B; Schrier, D; Song, Y, 1998) |
| ") on gastric ulcers induced by the oral administration of ethanol 50% (EtOH, 2 ml/rat) or indomethacin (indomethacin, 20 mg kg(-1), at a dosing volume of 5 ml) were investigated in rats." | 3.70 | Investigation on the mechanisms involved in the central protective effect of amylin on gastric ulcers in rats. ( Guidobono, F; Netti, C; Pagani, F; Sibilia, V; Ticozzi, C, 1998) |
| " This study examine oxygen free radical production (superoxide anions and hydrogen peroxide), gastric mucosa antioxidant defense mechanisms (glutathione, catalase, superoxide dismutase), the lesion-inducing effects of the generated oxygen free radicals (vascular permeability, lipid peroxidation) and gastric ulceration in rats treated orally with indomethacin at 10 mg/kg at 2 and 6 h after drug administration." | 3.70 | Role of antioxidants in gastric mucosal damage induced by indomethacin in rats. ( Hassan, A; Martin, E; Puig-Parellada, P, 1998) |
| " CR 2945 was about as efficacious as ranitidine against the indomethacin- and ethanol-induced gastric ulcers and the cysteamine-induced duodenal ulcer in rats." | 3.70 | Characterization of antisecretory and antiulcer activity of CR 2945, a new potent and selective gastrin/CCK(B) receptor antagonist. ( Impicciatore, M; Letari, O; Makovec, F; Mennuni, L; Revel, L, 1999) |
| "Since the sexual dimorphism of gastroduodenal ulcers is well known and might possibly relate to the actions of sex hormones, we studied the role of the female sex steroids, progesterone and 17beta-estradiol in cysteamine-induced mucosal ulcers in female Wistar rats (200-220 g)." | 3.70 | Dual effect of female sex steroids on drug-induced gastroduodenal ulcers in the rat. ( Drago, F; Làszlò, F; Montoneri, C; Varga, C, 1999) |
| " The gastric ulcerogenic response to indomethacin was markedly worsened in AA rats, depending on the degree of arthritic change." | 3.70 | Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide. ( Kato, S; Kunikata, T; Nishijima, M; Takeuchi, K; Tanaka, A, 1999) |
| "The healing of experimental gastric ulcers induced in rats is consistently delayed upon chronic treatment with indomethacin." | 3.70 | A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers. ( Amagase, K; Okabe, S, 1999) |
| "2 mmol/kg) on gastric ulcer on rats, induced by indomethacin was investigated." | 3.70 | Antiulcer effect of the N- and O-beta-D-glucopyranosides of 5-aminosalicylic acid. ( Csípõ, I; Pusztai, F; Szabó, G; Sztaricskai, F; Takács, IE, 1999) |
| " Our aim is to determine the antiinflammatory activity of deferiprone, an oral iron chelator, in experimental colitis and gastritis." | 3.70 | Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats. ( Ablin, J; Karmeli, F; Okon, E; Rachmilewitz, D; Shalev, O, 1999) |
| "Indomethacin (2 mg/100 g body weight), induces haemorrhagic gastric ulcers in albino rats." | 3.70 | Gastric mucosal cellular changes induced by indomethacin (NSAID) in male albino rats. ( Ahamed, RN; Sagar, V, 1999) |
| "The gastric ulcerogenic response to indomethacin was markedly increased in AA rats, depending on the degree of arthritic change." | 3.70 | The roles of nitric oxide and prostaglandins in alterations of ulcerogenic and healing responses in adjuvant-induced arthritic rat stomachs. ( Kato, S; Kunikata, T; Mizoguchi, H; Takeuchi, K; Tanaka, A, 2000) |
| " In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection." | 3.70 | The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000) |
| "Dothiepin, a tricyclic antidepressant, significantly inhibited the development of gastric ulcers induced by alcohol, aspirin, indomethacin and Shay's pyloric ligation." | 3.70 | Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids. ( Abdul Salam, CA; Nag Chaudhuri, AK; Pal, S; Sen, S; Sen, T, 2000) |
| " The spatial and temporal gelatinolytic activities of MMP-2 and MMP-9 were analyzed as a function of ulcer age, in homogenates of rat, indomethacin-induced, chronic gastric ulcers." | 3.70 | Matrix metalloproteinases 2 and 9 in indomethacin-induced rat gastric ulcer. ( Ahonen, J; Inkinen, K; Lempinen, M; Wolff, H, 2000) |
| "Studies were undertaken on the effect of a crude (TC) and an alkaloid fraction (TA) of the leaf extracts of Tylophora conspicua on indomethacin-induced gastric ulceration and gastric acid secretion in male albino rats." | 3.70 | Antiulcerogenic effects of Tylophora conspicua in male rats. ( Adesanwo, JK; Hammed, AI; Ogunwande, IA; Raji, Y, 2000) |
| "In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied." | 3.70 | [Celecoxib vs indomethacin and acute gastric lesions in rats]. ( Aramberry, LJ; Cesolari, JA; Esnarriaga, JM; Laudanno, OM; Maglione, CB; Piombo, G; Rista, L; Sambrano, JS, 2000) |
| " To evaluate whether immunosuppressants have a preventive effect against indomethacin-induced gastrointestinal damage, we investigated the effects of prednisolone, cyclosporin, and the newly developed immunosuppressant FK-506 in intracolonically indomethacin-treated rats: 24 mg/kg of indomethacin, administered intracolonically for two days, caused gastric ulcers and two types of small intestinal ulcers (longitudinal ulcers and scattered small ulcers)." | 3.69 | Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats. ( Fujishima, M; Hizawa, K; Iida, M; Kuroki, F; Matsumoto, T; Nakamura, S, 1994) |
| "The influence of (+/-)-verapamil and hydralazine on stress- and various chemically-induced gastric ulcers in rats together with their influence on various biochemical parameters which affect the development of the induced ulcers was examined." | 3.69 | Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats. ( al-Bekairi, AM; al-Rajhi, AM; Tariq, M, 1994) |
| "Indomethacin delays healing of experimental gastric ulcers." | 3.69 | Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin. ( Flogerzi, B; Halter, F; Peskar, BM; Schmassmann, A; Tarnawski, A; Varga, L, 1995) |
| "Effects of treatment with free radical scavengers in the healing process of acetic acid-induced gastric ulcer on the ulcer aggravation induced by indomethacin were investigated." | 3.69 | Effects of free radical scavengers on indomethacin-induced aggravation of gastric ulcer in rats. ( Kondo, M; Matsuyama, K; Naito, Y; Nishimura, S; Yagi, N; Yoshikawa, T, 1995) |
| "The effects of a ranitidine-zinc complex and ranitidine alone were compared in three different experimental models (pyloric ligation, ethanol and indomethacin) of gastric ulceration in the rat." | 3.69 | Cytoprotective and antisecretory activity of a ranitidine-zinc complex. ( Bravo, L; Bulbena, O; Conchillo, A; Mola, C; Navarro, C, 1995) |
| ") inhibited mepirizole-induced duodenal ulcers." | 3.69 | YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats. ( Akuzawa, S; Ito, H; Kamato, T; Kobayashi, A; Miyata, K; Nagakura, Y; Nishida, A; Takinami, Y; Yamano, M; Yuki, H, 1994) |
| " The effect of intravenous CGRP or intragastric capsaicin on gastric ulceration induced by 100 mmol/L HCl and indomethacin was studied in intact and endogenous CGRP-depleted rats." | 3.69 | A role for calcitonin gene-related peptide in protection against gastric ulceration. ( Bunnett, NW; Debas, HT; Gray, JL; Mulvihill, SJ; Orloff, SL, 1994) |
| " Homozygous Ptgs1 mutant mice survive well, have no gastric pathology, and show less indomethacin-induced gastric ulceration than wild-type mice, even though their gastric prostaglandin E2 levels are about 1% of wild type." | 3.69 | Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. ( Chulada, PC; Ghanayem, BI; Goulding, EH; Kim, HS; Kluckman, KD; Langenbach, R; Lee, CA; Loftin, CD; Mahler, JF; Morham, SG; Smithies, O; Tiano, HF, 1995) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 3.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process." | 3.69 | Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995) |
| "Indomethacin induces gastric ulcerations and decreases cell proliferation in the gastric ulcer margin." | 3.69 | Indomethacin interferes with epidermal growth factor binding and proliferative response of gastric KATO III cells. ( Arakawa, T; Fujiwara, Y; Halter, F; Schmassmann, A; Tarnawski, A, 1995) |
| "The present study was undertaken to determine the effect of a combination of selenium and vitamin E on stress and chemical-induced gastric ulcers in rats." | 3.69 | Effect of vitamin E and selenium on hypothermic restraint stress and chemically-induced ulcers. ( al-Moutairy, AR; Tariq, M, 1996) |
| "We have examined whether or not repeated treatment with indomethacin delays the healing of kissing gastric ulcers induced in rats." | 3.69 | Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats. ( Nozue, C; Okabe, S; Tsukimi, Y, 1996) |
| " Gastric ulcers were induced in young, adult, and aged rats using serosal or mucosal (kissing ulcers) application of acetic acid." | 3.69 | Influence of age on natural and delayed healing of experimentally-induced gastric ulcers in rats. ( Andrews, FJ; O'Brien, PE; Penney, AG, 1996) |
| " This same dose of omeprazole significantly reduced gastric ulcer formation induced by indomethacin despite significant (> 80%) inhibition of gastric mucosal prostaglandin E2 (PGE2) formation." | 3.69 | Omeprazole prevents indomethacin-induced gastric ulcers in rabbits. ( Feldman, M; Kallal, SM; Lee, M, 1996) |
| "The study was performed to examine whether indomethacin administered during the initial period of acetic acid-induced gastric ulcer healing affects future ulcer recurrence." | 3.69 | Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins. ( Arakawa, T; Fukuda, T; Higuchi, K; Kobayashi, K; Takaishi, O; Tarnawski, A; Watanabe, T; Yamasaki, K, 1996) |
| "Studies were performed in three models of acute gastric mucosal damage (induced by oral ethanol, aspirin and indomethacin) and a model of chronic gastritis (induced by 7 day treatment with iodoacetamide) in rats to establish the role of leukotrienes (LTs) in the pathogenesis of these lesions." | 3.69 | Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. ( Gyömber, E; Rainsford, KD; Szabo, S; Vattay, P, 1996) |
| " The effect of amylin on gastric ulcers induced by oral administration of indomethacin (Indo, 20 mg kg-1 at a dosing volume of 5 ml) or ethanol 50% (EtOH, 1 ml/rat) was investigated in conscious rats." | 3.69 | Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats. ( Guidobono, F; Netti, C; Pagani, F; Pecile, A; Sibilia, V; Ticozzi, C, 1997) |
| "We found indomethacin aggravates healed gastric ulcers (ulcer relapse) in rats." | 3.69 | Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. ( Asano, S; Inada, I; Maeda, R; Murakami, I; Sato, F; Satoh, H; Shino, A, 1997) |
| " Experimental gastric lesions were induced by water-immersion restraint stress, indomethacin and 80% ethanol in rats; whereas duodenal ulcers were produced by treatment of rats with cysteamine." | 3.69 | Effect of quinacrine, a phospholipase A2 inhibitor on stress and chemically induced gastroduodenal ulcers. ( Al Moutaery, AR; Tariq, M, 1997) |
| "The aim of this study was to examine the synthesis of sulfated glycosaminoglycans during normal healing of experimental acetic acid-induced gastric ulcer in rats and to investigate the effect of indomethacin, a drug known to delay ulcer healing, on this synthesis using an in vivo labelling system." | 3.69 | Changes in sulfated macromolecules produced in vivo during normal and indomethacin-delayed ulcer healing in rats. ( Andrews, FJ; Comper, WD; Lyons, KC; O'Brien, PE, 1997) |
| "The present study investigates the antisecretory and antiulcer mechanisms of a new indenopyridazinone derivative previously reported to inhibit gastric acid secretion in pylorus-ligated rats and to prevent gastric ulcerations induced by indomethacin or ethanol in the same animal species." | 3.69 | Study of the antisecretory and antiulcer mechanisms of a new indenopirydazinone derivative in rats. ( Ballabeni, V; Barlocco, D; Barocelli, E; Chiavarini, M; Dal Piaz, V; Impicciatore, M; Vianello, P, 1997) |
| "Immunohistological staining was done using the antibodies for the proliferating cell nuclear antigen prolyl 4-hydroxylase and alpha-smooth muscle actin in acetic acid induced gastric ulcers in rats." | 3.69 | Kinetics of fibroblasts in ulcer healing in rats: interference with indomethacin. ( Arisawa, T; Asai, J; Goto, H; Hase, S; Hayakawa, T; Hirose, Y; Niwa, Y; Tsukamoto, Y, 1997) |
| "The biosynthesis of sulfated mucin in gastric tissue was investigated in cold-stress and indomethacin (CSI)-induced gastric ulcer models." | 3.69 | Effect of cold-stress and indomethacin on the biosynthesis of gastric sulfated mucin in rats. ( Higuchi, S; Isobe, Y; Kijima, H; Kiuchi, Y; Muramatsu, M, 1997) |
| "Chronic gastric ulcers were induced with acetic acid in male Wistar rats and then treated with either aspirin (100 mg/kg/day), indomethacin (2 mg/kg/day), PDGF-BB (0." | 3.69 | Platelet-derived growth factor reverses the effects induced by NSAIDs on ulcer healing. ( Arceiz, E; Lanas, A; Ortego, J; Sáinz, R, 1997) |
| "We examined the effect of NC-1300-O-3 on the healing of acetic acid-induced gastric ulcers in male Donryu rats." | 3.68 | Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats. ( Inoue, K; Okabe, S; Takagi, K, 1993) |
| "Repeated administration of indomethacin delays the healing of acetic acid-induced gastric ulcers in rats, but the underlying mechanism remains unclear." | 3.68 | Mechanism by which indomethacin delays gastric ulcer healing in the rat: inhibited contraction of the ulcer base. ( Ogihara, Y; Okabe, S, 1993) |
| "Repeated administration of indomethacin or prednisolone for 2 weeks apparently delayed the healing of initial gastric ulcers induced by acetic acid injection in rats." | 3.68 | Effects of indomethacin and prednisolone on the different stages of healing of acetic acid-induced gastric ulcers in the rat. ( Ogihara, Y; Okabe, S, 1993) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| "We have tested the action of cloprostenol a relatively stable analogue of PGF2 alpha in experimentally induced gastric ulcer in rats by contention stress or indomethacin." | 3.68 | Influence of cloprostenol in the experimentally induced ulcer in rats. ( Adomnicăi, M; Dobrescu, G; Nechifor, M; Negru, A; Neughebauer, BI, 1992) |
| "This study was designed to elucidate the role of leukotrienes (LT) in indomethacin-induced gastric ulcers in relation to effects of clinically available anti-allergic drugs, azelastine (Azeptin, CAS 58581-89-8) and oxatomide (CAS 60607-34-3)." | 3.68 | Reduction of adverse effects of indomethacin by anti-allergic drugs in rat stomachs. ( Goto, H; Hamajima, E; Hoshino, H; Ohara, A; Ozawa, T; Sugiyama, S; Tsukamoto, Y, 1992) |
| "The role of oxygen-derived free radicals in the pathogenesis of acute gastric ulceration induced by indomethacin (Indo) was investigated in rats." | 3.68 | Role of oxygen-derived free radicals in indomethacin-induced gastric injury. ( Meddings, JB; Vaananen, PM; Wallace, JL, 1991) |
| " The compound had no activity against cysteamine-induced duodenal ulcers and lost its cytoprotective activity in adrenalectomised rats." | 3.68 | BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat. ( Bruno, M; Grassi, A; Ippen, J; Thomas, G, 1991) |
| "The effects of dopamine (DA) agonists and antagonists were investigated on indomethacin--and restraint stress (6 hr at RT)--induced gastric ulcer formation in rats." | 3.68 | Possible prostaglandin-dopamine interactions during experimental gastric ulcer formation. ( Khanna, N; Ray, A; Sen, P, 1990) |
| "Repeated administration of indomethacin markedly delays spontaneous healing of experimental gastric ulcers induced in rats." | 3.68 | Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. ( Hirose, H; Okabe, S; Takeuchi, K, 1991) |
| " SK&F 105809 inhibited oedema and inflammatory-cell infiltration in arachidonic acid-induced inflammation in the mouse ear and rat paw as well as in carrageenan- and monosodium urate crystal-induced peritonitis." | 3.68 | Pharmacological profile of SK&F 105809, a dual inhibitor of arachidonic acid metabolism. ( Adams, J; Bender, P; Dimartino, MJ; Griswold, DE; Hanna, N; Kirsh, R; Marshall, PJ; Newton, J; Schwartz, L, 1990) |
| "We studied the effect of the angiotensin converting enzyme inhibitor, captopril, on two models of gastric ulcers; oxyphenbutazone and ethanol-induced lesions." | 3.68 | Effect of captopril on oxyphenbutazone and ethanol-induced gastric lesions in rats. ( Bhounsule, SA; Diniz D'Souza, RS; Hede, SS; Pereira, JS, 1990) |
| "Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats." | 3.68 | Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats. ( Nagai, H; Okabe, S; Wang, JY, 1990) |
| "We examined the effects of orally administered human epidermal growth factor (hEGF) on healing of acetic acid-induced gastric ulcers in rats." | 3.68 | Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. ( Imoto, Y; Kuwahara, Y; Okabe, S; Sunagawa, Y, 1990) |
| "Levamisole, in doses similar to those required to observe immunostimulation in animals, antagonized dose-dependently, in rats, gastric ulcers produced by necrotizing agents (HCl and ethanol) and NSAIDs (indomethacin and piroxicam) without affecting the anti-inflammatory properties of these latter drugs." | 3.67 | The effect of levamisole on gastric ulcers induced in the rat by anti-inflammatory and necrotizing agents. ( Evangelista, S; Maggi, CA; Meli, A, 1984) |
| "0 mg/kg) and DMPG (10-40 micrograms/kg) overcame morphine-induced constipation in a dose-related manner, the respective ED50s being 0." | 3.67 | M&B 28,767: a potent anti-secretory and anti-ulcer PG analogue. A comparative study with 16, 16' dimethyl PGE2 methylester. ( Banerjee, AK; Christmas, AJ; Crowshaw, K; Heazell, MA; Ivers-Read, GC; Saunders, LC; Wyatt, D, 1984) |
| " Pelsonin a combination of indomethacin and sodium salicylate (1:10 ratio) has a cytoprotective effect against acidic-alcohol induced gastric necrosis, and it does not induce intestinal ulceration." | 3.67 | Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat. ( Ezer, E; Matuz, J; Pallagi, K; Szporny, L, 1984) |
| "The effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on various experimental gastric ulcers and gastric secretion in experimental animals was compared with that of cimetidine and cetraxate." | 3.67 | Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals. ( Aratani, S; Enomoto, H; Kimura, K; Mimura, K; Nomura, A; Ueda, F, 1984) |
| "This study shows that human fundic mucosa generates various PGs, particularly PGE2, and thromboxanes and this generation appears to be significantly lower in gastric ulcer than in duodenal ulcer patients or normal subjects." | 3.67 | Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC). ( Konturek, SJ; Kopp, B; Kwiecień, N; Obtułowicz, W; Oleksy, J; Sito, E, 1984) |
| " FCE 20700 was more potent than PGE2 in the prevention of stress-induced gastric ulcers (ED50 = 262 and 787 mcg/kg) and indomethacin-induced intestinal ulcers (ED50 = 557 and 4569 mcg/kg), and showed the same potency as PGE2 in the prevention of ethanol (ED50 = 9." | 3.67 | Cytoprotective and antisecretory effects of 11-deoxy-13,14-didehydro-16(s)-methyl PGE2 methylester (FCE 20700). ( Arrigoni, C; Ceserani, R; Faustini, F; Mizzotti, B; Toti, D, 1984) |
| " Acutely induced gastric ulcers or erosions such as Shay ulcers, water-immersion stress-, indomethacin-, aspirin-, or prednisolone-induced erosions were all markedly inhibited by oral or intraduodenal administration of 10-100 mg/kg of omeprazole." | 3.67 | Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984) |
| "The interaction between reserpine and nonsteroidal anti-inflammatory agents ( NSAIA ) in producing experimental gastric ulcers was studied in rats." | 3.67 | Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats. ( Radmanović, BZ; Sćepović, Z, 1984) |
| " AY-28,200 blocked acetylsalicylic acid and stress-induced gastric ulcers but was inactive against indomethacin-induced gastric ulcers." | 3.67 | Gastric antisecretory and antiulcer/cytoprotective effects of 2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester. ( Borella, LE; DiJoseph, JF, 1989) |
| " Whereas gastric ulcers were produced by ulcerogenic agents including indomethacin, aspirin and reserpine, beside hypothermic restraint stress and by pylorus ligated Shay rat technique." | 3.67 | Gastroprotective activity of ginger zingiber officinale rosc., in albino rats. ( Ageel, AM; al-Yahya, MA; Mossa, JS; Parmar, NS; Rafatullah, S; Tariq, M, 1989) |
| "We examined the effect of human epidermal growth factor (hEGF) on the healing rate of gastric ulcers induced in rats." | 3.67 | Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. ( Kuwahara, Y; Okabe, S, 1989) |
| " Indomethacin-induced gastric ulcer was inhibited by cysteamine of 132 and 264 mumol, i." | 3.67 | [The role of sulfhydryls in indomethacin-induced gastric mucosal injury in rats]. ( Liu, JL; Wang, CC; Zhang, XJ, 1989) |
| ") inhibited restraint and water-immersion-induced stress, ulcers, indometacin- and absolute ethanol-induced gastric ulcers and mepirizole-induced duodenal ulcers in rats in a dose-dependent manner." | 3.67 | Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats. ( Bickel, M; Goto, M; Hayashi, S; Herling, AW; Sakurai, M; Tanaka, T, 1989) |
| " Magaldrate afforded protection against gastric necrotic lesions induced by absolute ethanol (ED50, as magaldrate, 419 mg/kg); gastric ulcers induced by acidified acetylsalicylic acid (ED50 540 mg/kg), stress (cold restraint, ED50 388 mg/kg), indometacin (ED50 281 mg/kg), and pylorus ligation; and intestinal ulcers induced by cysteamine (ED50 243 mg/kg) and indometacin (ED50 184 mg/kg)." | 3.67 | Cytoprotective and antiulcer activities of the antacid magaldrate in the rat. ( Borella, LE; DiJoseph, JF; Mir, GN, 1989) |
| "Effects of systemically administered gamma-aminobutyric acid (GABA) on indomethacin-induced gastric ulceration were studied in rats." | 3.67 | Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors. ( Hara, S; Morioka, S; Satoh, K; Yanagihara, S, 1988) |
| ", prevented the formation of gastric ulcers induced by exposure to stress, pylorus-ligation, both pylorus-ligation and acetylsalicyclic acid, indometacin or reserpine in rats." | 3.67 | Effects of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)-acetoxyacetamide hydrochloride (TZU-0460), a histamine H2-receptor antagonist, on gastric acid secretion and ulcer formation. ( Mieda, M; Sakuma, H; Shiratsuchi, K; Tarutani, M, 1985) |
| "We examined the mechanism by which repeated administration of indomethacin significantly delays the natural healing of experimental gastric ulcers induced in rats." | 3.67 | Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin. ( Okabe, S; Takeuchi, K; Wang, JY; Yamasaki, S, 1989) |
| " On the other hand, protective effects of PGM on diarrhea induced by arachidonic acid in mice were about 1/2 times as potent as those of IND in both 1 and 4 hr pretreatments." | 3.67 | [Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract]. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1986) |
| "Adrenalectomy enhances the degree of gastric ulcers induced in rats by indomethacin or acetylsalicylic acid (ASA), but not that induced by 96% ethanol." | 3.67 | Further studies on the role of the adrenals in the capsaicin-sensitive "gastric defence mechanism". ( Evangelista, S; Giuliani, S; Maggi, CA; Meli, A, 1988) |
| " However they possess antiulcer properties lower than the reference compound against Indomethacin-induced gastric ulcers." | 3.67 | [Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure]. ( Evangelista, S; Ghelardoni, M; Meli, A; Pestellini, V; Viti, G, 1988) |
| "Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug." | 3.67 | Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. ( Fielder, FG; Ginsberg, RS; Godin-Ostro, E; Slusher, MA; Soehngen, EC; Weiner, AL, 1988) |
| " The effect of the inhibition of endogenous prostaglandin generation by indomethacin on these parameters was also investigated in this model of endotoxin shock." | 3.67 | Indomethacin potentiates endotoxin-induced blood flow reduction and histological injury in rat gastric mucosa. ( Guth, PH; Leung, FW; Piqué, JM; Whittle, BJ; Yonei, Y, 1988) |
| "We investigated whether the trophic actions of prostaglandins, omeprazole, and indomethacin on gastric mucosa lead to accelerated healing of gastric ulcers in the rat." | 3.67 | Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. ( Baumgartner, A; Halter, F; Inauen, W; Kayser, S; Koelz, HR; Schürer-Maly, CC; Wyss, PA, 1988) |
| "Clonidine and paraaminoclonidine prevented the formation of indomethacin-induced gastric ulcers in female rats." | 3.67 | Antiulcer activity of clonidine: lack of effect on gastric prostaglandins. ( Ben-Zvi, Z; Leibson, V, 1987) |
| " The anti-inflammatory properties of FPP028 were evaluated through the carrageenan induced paw edema and the cotton pellet induced granuloma and compared with the activity of indomethacin, phenylbutazone, and isoxicam; as a result, the activity of FPP028 was shown to be similar to that of the latter compounds." | 3.67 | Pharmacological activity of FPP028 (2-phenylpyrazolo-4-ethyl-4,7-dihydro [1,5a]pyrimidin-7-one) a new non-steroid anti-inflammatory agent. ( Banchelli, G; Bianchini, F; Ignesti, G; Pecori-Vettori, L; Pirisino, R; Rafanelli, D; Raimondi, L, 1986) |
| "The purpose of these studies was to determine the role played by endogenous prostaglandins in the development of gastric ulcers produced by indomethacin, and of duodenal ulcers produced by mepirizole in rats." | 3.67 | Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats. ( Jacobson, ED; Joffe, SN; Robert, A; Tabata, K, 1987) |
| "Gastric ulcerations induced in rats by a combination of indomethacin and cold-stress (5 +/- 1 degrees C) for 6 hr were more severe than those induced by indomethacin or cold-stress alone." | 3.67 | Effects of indomethacin and cold-stress on gastric acid secretion and ulceration. The effects of anti-acid secretory agents in rats. ( Aihara, H; Arai, I; Hirose, H; Muramatsu, M; Usuki, C, 1987) |
| "The main constituents of the ethanol extract of Pyrenacantha staudtii leaves were identified to be triterpenoid saponins and orally this extract was shown to protect rats from developing gastric ulcers induced by various experimental models: drugs (indomethacin, serotonin), cold-restraint stress and Shay rat." | 3.67 | Gastrointestinal studies of Pyrenacantha staudtii leaf extracts. ( Aguwa, CN; Okunji, CO, 1986) |
| "Capsaicin desensitization increases the degree of indomethacin-induced gastric ulcers in sham-operated but not in adrenalectomized rats." | 3.67 | Evidence for a role of adrenals in the capsaicin-sensitive "gastric defence mechanism" in rats. ( Evangelista, S; Maggi, CA; Meli, A, 1986) |
| " It inhibited dose dependently gastric ulcers produced by acidified aspirin, water immersion and restraint stress." | 3.67 | Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins. ( Aihara, H; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Muramatsu, M; Piastucki, I; Radecki, T; Tanaka, M, 1986) |
| "The effect of zinc sulphate on stomach ulceration produced by ethanol and indomethacin was examined in rats." | 3.67 | Effects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosa. ( Cho, CH; Koo, MW; Ogle, CW; Wong, SH, 1985) |
| " Acetazolamide increased the gastric ulcerogenicity of indomethacin, but inhibited gastric ulcers produced by acidified aspirin." | 3.67 | Ulcer formation and cytoprotection by acetazolamide. ( Davis, JP; Kolbasa, KP; Lancaster, C; Nezamis, JE; Robert, A, 1985) |
| " prevented formation of ulcers induced by serotonin, indomethacin, acetylsalicylic acid or stress (acute ulcer models), its effect being greater against gastric ulcers induced by serotonin." | 3.67 | Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103). ( Hoshina, K; Naruchi, T; Takeshita, T; Yamazaki, N, 1985) |
| "Effects of several non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin (ASA), indomethacin (IM), flurbiprofen (FP), ibuprofen (IP), phenylbutazone (PBZ) and flufenamic acid (FA) were studied on the gastric ulceration and gastric acid secretion induced by restraint and water-immersion stress (RWIS) or various secretagogues in rats." | 3.67 | Possible involvement of non-steroidal anti-inflammatory drugs in vagal-mediated gastric acid secretion in rats. ( Aihara, H; Arai, I; Hirose, H; Muramatsu, M; Okuyama, S, 1985) |
| "Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats." | 3.67 | Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985) |
| "With the carrageenin food oedema assay, we studied in rats the effects of indomethacin on inflammation, gastric ulcers and lipid peroxide levels." | 3.67 | Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats. ( Planas, JM; Puig-Parellada, P, 1985) |
| " Oral or intraduodenal administration of AG 629 in a dose range of 25-100 mg/kg inhibited water-immersion stress ulcer, exertion ulcer, Shay ulcer, indometacin- and acetylsalicylic acid (ASA)-induced gastric ulcer, and indomethacin-induced small intestinal ulcer in rats, histamine-induced gastric ulcer in guinea pigs, and ASA-induced gastric ulcer in dogs, though it was not effective against cysteamine-induced duodenal ulcer in rats." | 3.67 | Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers. ( Hirata, T; Inada, I; Inatomi, N; Maki, Y; Satoh, H; Sino, A, 1985) |
| " D-penicillamine showed a dose dependent antiulcerogenic effect in both gastric ulcer models." | 3.67 | The effect of D-penicillamine in different experimental gastric ulcer models in the rat. ( Bálint, GA; Varró, V, 1985) |
| " Three of the most active compounds (4, 18a, and 18e) were tested in the rat adjuvant arthritis model and found to be essentially equivalent in activity to indomethacin." | 3.66 | Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides). ( Carter, GW; Cimon, DG; Garmaise, DL; Paris, GY; Swett, L; Young, P, 1980) |
| "Gastric ulcer was provoked by indomethacine (20 mg/kg s." | 3.66 | The relationships between indomethacine-induced gastric ulcer, ulcer protection by cimetidine and prostacyclin and the cAMP system of the gastric fundic mucosa in the rat. ( Bata, M; Fiegler, M; Jávor, T; Morón, F; Mózsik, G, 1982) |
| " Fenflumizole was comparable to or weaker than indomethacin in models of acute inflammation (carrageenin paw oedema and pleurisy, rats, ultraviolet erythema, guinea-pigs) and stronger than indomethacin as an analgesic (writhing, mice)." | 3.66 | Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative. ( Corell, T; Hasselmann, G, 1983) |
| "The erythro version of 1, 4,-dimercapto-2, 3,-butanediol provided a significant protection against experimental gastric ulcer induced by indomethacin, while it was ineffective in stress ulcer of rats." | 3.66 | Different protective effects of dimercapto-butanediol stereoisomers in experimental gastric ulceration. ( Balint, GA; Varró, V, 1983) |
| "Sodium salicylate (SA) has been reported to inhibit the formation of gastric ulcerations induced by aspirin, indomethacin, and absolute ethanol." | 3.66 | Effect of prostaglandin synthesis inhibitors on neurotensin and sodium salicylate-induced gastric cytoprotection in rats. ( Adcock, JE; Hernandez, DE; Nemeroff, CB; Prange, AJ, 1983) |
| ") also inhibited gastric ulcers provoked by aspirin, aspirin + acid, indomethacin and stress (cold-restraint) in rats." | 3.66 | Gastric antisecretory and cytoprotective activities of SCH 28080. ( Chiu, PJ; Derelanko, MJ; Long, JF; Steinberg, M, 1983) |
| " However, SM powder had no effect on water-immersion stress- or aspirin-induced gastric lesions and mepirizole-induced duodenal ulcers." | 3.66 | [Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats]. ( Ikenishi, H; Ohmi, F; Okabe, S; Takaoka, A; Takeuchi, K, 1983) |
| "Effects of indomethacin on healed partially healed gastric ulcers in the dog were studied." | 3.66 | Does indomethacin activate healed gastric ulcers in the dog? ( Okabe, S; Tabata, K, 1981) |
| " Gastric ulceration was induced by physical restraint in rats and by indomethacin treatment in dogs." | 3.66 | Gastrointestinal myoelectric activity disturbances in gastric ulcer disease in rats and dogs. ( Bueno, L; Fioramonti, J, 1980) |
| "A combination of indomethacin and diflunisal, a new salicylic acid derivative, when given to rats, gave a greater reduction in the size of permanganate induced granulomas and less gastric irritation, than either drug given alone." | 3.66 | Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal. ( Conti, P; Continenza, A, 1980) |
| "Experimental models of chronic and acute peptic ulcerations were produced in the albino rats by means of prolonged starvation and indomethacin administration." | 3.66 | Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats. ( Elegbe, RA, 1978) |
| " 4 Studies with cimetidine, have shown that the enhancement of anti-oedema effects produced by fasting are due to specific pharmacological properties of indomethacin rather than to non specific effects related to the presence of gastric ulcers." | 3.66 | Influence of fasting and cimetidine on the relationship between ulcerogenic and anti-inflammatory properties of indomethacin. ( Del Soldato, P; Meli, A; Volterra, G, 1979) |
| "Bilateral adrenalectomy markedly aggravated gastric ulcers in rats induced by 5 or 20 mg/kg of indomethacin." | 3.66 | The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat. ( Kasuya, Y; Okabe, S; Urushidani, T, 1979) |
| " Indomethacin treatment precipitated gastric ulceration, which led to the formation of a gastro-colic fistula." | 3.66 | Gastro-colic fistula secondary to benign gastric ulceration. ( Taylor, R, 1978) |
| "Gastric ulceration produced by aspirin and indomethacin was compared in acutely stressed and non-stressed rats." | 3.66 | Aspirin- and indomethacin-induced ulcers and their antagonism by antihistamines. ( Brown, PA; Sawrey, JM; Vernikos, J, 1978) |
| " Concomitant oral administration of aspirin or subcutaneous administration of indomethacin revealed an aggravation of aspirin-induced gastric ulcers by betamethasone valerate and inhibition of indomethacin-induced intestinal ulcers by beta-methasone dipropionate." | 3.66 | [Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs (author's transl)]. ( Ishihara, Y; Izumi, K; Kunimi, H; Okabe, S; Tabata, K; Uchida, N, 1978) |
| " In the carrageenan edema test, eight compounds exhibited higher antiinflammatory activities than did indomethacin." | 3.65 | 6,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity. ( Kubo, S; Tagawa, H; Tsukada, W; Ueno, K; Yoshioka, T, 1976) |
| "The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied." | 3.65 | Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977) |
| "Indomethacin produces gastric ulceration in the rat when given by subcutaneous injection." | 3.65 | Effect of salbumatol on acute gastric ulceration induced by indomethacin in the rat. ( Curwain, BP; Fielding, LP; Raute, M, 1977) |
| "Ionic permeability of the gastric mucosa was measured in six patients with an acute exacerbation of severe generalized rheumatoid arthritis receiving either aspirin and prednisone or aspirin and indomethacin as therapy." | 3.65 | Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis. ( Clifton, JA; Ivey, KJ, 1974) |
| "Dyspeptic symptoms, gastrointestinal bleeding, or the development of anaemia without dyspepsia in patients treated with indomethacin may be manifestations of peptic ulceration." | 3.64 | Gastric ulceration occurring during indomethacin therapy. ( Hart, FD; Huskisson, EC; Taylor, RT; Trapnell, DH; Whitehouse, GH, 1968) |
| "Topiramate pretreatment also reduced the contents of tissue malonaldehyde, enhanced ferric reducing antioxidant power value and glutathione levels, and increased the activity of superoxide dismutase, catalase, and glutathione peroxidase in gastric mucosa compared to the model group." | 3.11 | Gastroprotective effect of topiramate on indomethacin-induced peptic ulcer in rats: Biochemical and histological analyses. ( Andishfar, N; Esmaeilzadeh, Z; Ghasemnejad-Berenji, M; Jafari, A; Khezri, MR, 2022) |
| "Indomethacin is an indol derivative, non-steroidal, anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects." | 2.46 | Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. ( Albayrak, A; Bilici, M; Cadirci, E; Halici, Z; Suleyman, H, 2010) |
| " To investigate the mechanism of action, conducted assays of antioxidant activity, measured the dosage of inflammatory cytokines, quantified mucus, treated with inhibitors (IND, L-NAME, glibenclamide, and yohimbine), performed histopathological analysis, and measured gastric acid secretion." | 2.44 | Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models. ( Arunachalam, K; Damazo, AS; Figueiredo, FF; Martins, DTO; Muller, JAI; Oliveira, DM; Serio, BFD; Silva, MJD; Venturini, CL, 2024) |
| "Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects." | 1.91 | Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1. ( El-Demerdash, E; Hamza, SE; Wahdan, SA, 2023) |
| "The prevalence of gastric ulcers is increasing worldwide, especially those brought on by non-steroidal anti-inflammatory drugs (NSAIDS), so prevention is extremely crucial." | 1.91 | Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats. ( Abu-Risha, SE; Elsisi, AE; Mekky, EF, 2023) |
| "Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties." | 1.91 | Effect of felodipine on indomethacin-induced gastric ulcers in rats. ( Akbaş, EM; Akbaş, N; Gülaboğlu, M; Mammadov, R; Süleyman, B; Süleyman, H, 2023) |
| "Metformin (500 mg/kg) was given orally for 3 days prior to indomethacin or ethanol challenge." | 1.72 | The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats. ( Alican, İ; Aydın, B; Cabadak, H; Cumbul, A; Ercan, F; İpek, BE; Yüksel, M, 2022) |
| "Gastric ulcer has been a major cause of morbidity and mortality worldwide, and it has been linked to factors such as nutritional deficiency, smoking, stress, and continuous intake of non-steroidal antiinflammatory drugs (NSAIDs)." | 1.72 | Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model. ( Carvalho, MF; Costa, EA; Fajemiroye, JO; Fava, SA; Ghedini, PC; Gil, ES; Gomes, EH; Macedo, IYL; Martins, JLR; Pinto, EMH; Rocha, FF; Silva, DM; Silva, ON, 2022) |
| "Olmesartan (OLM) has potent anti-oxidant and anti-inflammatory characters, yet having limited bioavailability." | 1.62 | Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway. ( Darwish, SF; El-Dakroury, WA; Radwan, E; Sallam, AM, 2021) |
| "Rebamipide (REB) a potent anti-ulcer agent, has not been exploited to its full potential, owing to it extremely poor solubility, leading to highly diminutive bioavailability (<10%)." | 1.62 | Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies. ( Chadha, R; Dureja, J; Jindal, A; Karan, M; Singh, R; Tomar, S, 2021) |
| "Rheumatoid arthritis is an autoimmune inflammatory disease with progressive degradation of cartilage and joints." | 1.62 | Nerolidol-beta-cyclodextrin inclusion complex enhances anti-inflammatory activity in arthritis model and improves gastric protection. ( Cavalcanti, MD; de Albuquerque Júnior, RLC; de Lima, CM; de Souza Araújo, AA; de Souza Carvalho, FM; de Souza, EPBSS; Dos Santos Lima, B; Gomes, MVLD; Júnior, LJQ; Marreto, RN; Shanmugan, S; Silva, LAS, 2021) |
| "Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels." | 1.62 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021) |
| "Indomethacin treatment revealed histopathological changes and ulcer scoring and ulcer index were markedly increased." | 1.62 | Possible protective effect of TNF-α inhibition and triad NO/cGMP/VEGF activation on gastric ulcer in rats. ( Abd Al Haleem, EN; Arafa, HMM; Ibrahim, FAM; Zaytoon, SAB, 2021) |
| "Pinocembrin (PINO) is a natural flavonoid retaining anti-microbial, anti-oxidant, and anti-inflammatory activities." | 1.62 | Protective and therapeutic effects of the flavonoid "pinocembrin" in indomethacin-induced acute gastric ulcer in rats: impact of anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms. ( El-Demerdash, AA; Elsherbiny, DA; Esmat, A; Menze, ET; Tadros, MG, 2021) |
| "Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate-Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline)." | 1.56 | Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats. ( Atusiimirwe, JK; Ayikobua, ET; Kalange, M; Kasolo, J; Kasozi, KI; Matama, K; Munanura, EI; Namulema, J; Nansunga, M; Okpanachi, AO; Semuyaba, I; Ssempijja, F; Zirintunda, G, 2020) |
| "Gastric ulcers were induced in male Sprague-Dawley (SD) rats with a single oral dose of 150 mg/kg IND." | 1.56 | Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway. ( Cai, X; Chen, X; Hou, X; Peng, J; Peng, Q; Song, H; Xu, F; Yang, T; Yu, R; Zeng, M, 2020) |
| "Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-inflammatory drugs (NSAIDs), stress conditions, and alcohol, resulting in an inflammatory condition in the gastric mucosa." | 1.56 | Involvement of nitric oxide pathway in the anti-inflammatory effect of modafinil on indomethacin-, stress-, and ethanol -induced gastric mucosal injury in rat. ( Dehpour, AR; Dejban, P; Eslami, F; Jahansouz, M; Rahimi, N; Takzare, N, 2020) |
| "Gastric ulcer is one of the most prevalent diseases worldwide." | 1.51 | Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach. ( Amiri-Dashatan, N; Dadpay, M; Farrokhi Yekta, R; Goshadrou, F; Koushki, M, 2019) |
| "Corticosterone levels were elevated under formation of gastric erosions (4 hours after IM injection) but decreased following their healing (24 and 48 hours IM injection)." | 1.51 | Effects of stress preconditioning on vulnerability of gastric and small intestinal mucosa to ulcerogenic action of indomethacin in rats. ( Filaretova, LP; Yarushkina, NI, 2019) |
| "Paeonol pretreatment diminished gastric oxidative stress and restored the gastric antioxidant capacity by elevating gastric gene expression of HO-1 and protein expression of NQO1." | 1.51 | Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats. ( Hafez, HM; Mohamed, MZ; Morsy, MA; Zenhom, NM, 2019) |
| "The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide." | 1.51 | Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice. ( Alves, GM; Assis, ALEM; Athaydes, BR; Campagnaro, BP; Gomes, JVD; Gonçalves, RCR; Kitagawa, RR; Kuster, RM; Nogueira, BV; Pereira, TMC; Rodrigues, RP; Silveira, D, 2019) |
| "Gastric ulcer is a common problem affecting the gastrointestinal tract." | 1.51 | A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats. ( Abdelwahed, MK; Ahmed, EI; Boushra, AF; Elsayed, AM; Ibrahim, NA, 2019) |
| "Gastric ulcer was induced by a single oral gavage of 48 mg/kg IND." | 1.48 | Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats. ( Anvari, M; Bagheri, SM; Mirjalili, A; Momeni-Asl, H; Yadegari, M; Zare-Mohazabieh, F, 2018) |
| "Indomethacin (0." | 1.48 | Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats. ( Chen, F; Gong, J; Jiang, J; Li, H; Tan, Y; Zhang, J; Zhang, X; Zhang, Z, 2018) |
| "Thymol is a monoterpene phenol with many different pharmacological activities." | 1.48 | Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model. ( Aysin, F; Cerig, S; Erol, HS; Geyikoglu, F; Koc, K; Ozek, NS; Yilmaz, EG, 2018) |
| "Crocin is a novel agent that has potential in the prevention of ulceration induced by NSAIDs." | 1.43 | Protective activity of crocin against indomethacin-induced gastric lesions in rats. ( Ahmadi, I; Khani, MZ; Mard, SA; Mojahedin, S; Neisi, N; Pipelzadeh, MH; Teimoori, A, 2016) |
| "Fluoxetine (20 mg/kg) was administered IP for 14 days." | 1.43 | Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats. ( Elsayed Elsayad, M; Sabri Ali, H; Salem Sokar, S, 2016) |
| " Each rat to receive nebivolol and omeprazole was given the agent orally (by gavage) daily for 10 days prior to induction of ulcer by oral dosing with INDO." | 1.43 | Nebivolol prevents indomethacin-induced gastric ulcer in rats. ( El-Ashmawy, NE; El-Bahrawy, HA; Khedr, EG; Selim, HM, 2016) |
| "Aliskiren was able to inhibit indomethacin-induced ulcer formation." | 1.43 | Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Kose, D; Polat, B; Topcu, A, 2016) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug, which is known to produce serious side effects, causing ulcerative lesions." | 1.42 | Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms. ( Cantali-Ozturk, C; Deniz, R; Kolgazi, M; Ozdemir-Kumral, ZN; Sirvanci, S; Yeğen, BC; Yuksel, M, 2015) |
| "sacarolha in the treatment of gastric ulcers and that it has a multi-targeted action." | 1.42 | Helicteres sacarolha A. St.- Hil. et al.: gastroprotective and possible mechanism of actions in experimental animals. ( Balogun, SO; Damazo, AS; de Oliveira Martins, DT, 2015) |
| "As numerous herbal products have been used as dietary supplements or functional foods, the demands of the pharmacokinetic and pharmacodynamic characteristics of active compounds are increasing in order to secure a consistent outcome (i." | 1.42 | In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. ( Chae, HS; Chin, YW; Choi, YH; Kim, YJ, 2015) |
| "Ilaprazole is a novel proton pump inhibitor that has been marketed as an oral therapy for acid-related diseases in China and Korea." | 1.40 | Intravenous ilaprazole is more potent than oral ilaprazole against gastric lesions in rats. ( Gong, ZH; Hou, XM; Hu, HT; Lu, XQ; Su, RB; Xie, HZ; Yu, G, 2014) |
| " However, these preventive effects of SAC were dependent on dosage of SAC; higher dose above 10 μM paradoxically aggravated NSAID-induced inflammation." | 1.40 | S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibition. ( Hahm, KB; Han, YM; Jung, MK; Kangwan, N; Kim, EH; Lee, SY; Park, JM, 2014) |
| "Metyrapone pretreatment allowed us to prevent the acute corticosterone response to CRF and avoid the lasting effects of glucocorticoid deficiency." | 1.40 | [Metyrapone effect on gastroprotective action of corticotropin-releasing factor administered centrally against indomethacin-induced gastric injury]. ( Bagaeva, TR; Filaretova, LP; Miazina, MA, 2014) |
| "Indomethacin (IND) is a non-steroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions." | 1.39 | Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. ( Abbas, AM; Sakr, HF, 2013) |
| "Indomethacin ulcers were produced by oral administration of 30 mg/kg bw in the rats pretreated with B-Hb one hour before indomethacin." | 1.39 | Gastric antisecretory and antiulcer activity of bovine hemoglobin. ( Al Asmari, AK; Al Asmary, S; Al Malki, A; Al Omani, S; Elfaki, I; Tariq, M, 2013) |
| "Montelukast is an anti-asthmatic drug, a selective reversible cysteinyl leukotriene D4 receptor antagonist." | 1.39 | Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model. ( Cadırcı, E; Ozbakış-Dengiz, G; Yurdakan, G, 2013) |
| " Long-term use of these drugs is associated with significant gastric injury." | 1.38 | Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers. ( Berg, DJ; Buettner, GR; Uc, A; Wagner, BA; Zhu, X, 2012) |
| "Pretreatment with curcumin caused leukocyte adherence to postcapillary venule to decline (3." | 1.38 | Curcumin prevents indomethacin-induced gastropathy in rats. ( Chayanupatkul, M; Choochuai, S; Klaikeaw, N; Patumraj, S; Thong-Ngam, D, 2012) |
| "Simvastatin treatment activated free radical oxidation, which was seen from enhanced chemiluminescence in the mucosa homogenate (by 1." | 1.38 | Effect of HMG-CoA-reductase inhibitor on DNA synthesis and free radical oxidation in the gastric mucosa under normal conditions and during indometacin-induced ulcerative process in the stomach of albino mice. ( Bragina, VV; Fleischman, MY; Lebedko, OA; Sazonova, EN; Timoshin, SS; Zhivotova, EY, 2012) |
| "Indomethacin (10 mg/kg) was administered orally in fasted or fed rats, and gastrointestinal lesions were examined 24 h after indomethacin administration." | 1.38 | Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility. ( Amagase, K; Satoh, H; Takeuchi, K, 2012) |
| "Pretreatment with candesartan for 10 days reduced significantly the ulcer index induced by indomethacin injection." | 1.38 | Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats. ( Awad, AS; El Morsy, EM; Kamel, R, 2012) |
| "Indomethacin was orally administered to induce an acute gastric injury (3, 10 and 30mg/kg)." | 1.38 | Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. ( Castañeda-Hernández, G; Chávez-Piña, AE; Jiménez-Andrade, JM; Pineda-Peña, EA, 2012) |
| "05), in a dosage range from 4." | 1.37 | Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models. ( Badilla, B; García-Barrantes, PM, 2011) |
| "Risperidone pretreatment reverses the stress induced alteration in hexosamine, PGE(2) and microvascular permeability." | 1.37 | Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions. ( Krishnamurthy, S; Saxena, B; Singh, S, 2011) |
| "Chronic gastric ulcers were induced by serosal application of acetic acid." | 1.37 | Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair. ( Chadee, K; Dharmani, P; Srivastava, V; Vong, L; Wallace, JL, 2011) |
| "Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions." | 1.37 | Curative effect of selenium against indomethacin-induced gastric ulcers in rats. ( Kim, BW; Kim, JH; Kwon, HJ; Nam, SW, 2011) |
| "Paroxetine (1-10 mg/kg) was given orally 30 min before indomethacin." | 1.37 | Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats. ( Amagase, K; Gyenge, M; Kojo, A; Nukui, K; Takeuchi, K; Tanaka, A, 2011) |
| "Gastric ulcers were generated in rats by administration of 70% ethanol, and activity of doxycycline was tested by administration 30 min prior to ethanol." | 1.37 | Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress. ( Mishra, A; Saha, D; Singh, LP; Swarnakar, S, 2011) |
| " Oral administration of IAC dosed at 50 and 100 mg/kg was able to significantly prevent gastric ulceration induced by indomethacin and by stress." | 1.37 | Further evidence of the antiulcer activity of IAC, a novel free radical scavenger. ( Baraldi, M; Carnevale, G; Zanoli, P; Zavatti, M, 2011) |
| "Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e." | 1.36 | Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010) |
| " For these studies, animals were dosed with CP-154,526 (3, 10, 30 mg/kg) and NBI 27914 (1-30 mg/kg) 1 h prior to the assessment of tactile, thermal or mechanical hypersensitivity, respectively." | 1.36 | Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. ( Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT, 2010) |
| " The antiulcerogenic effects of erythropoietin may be related to its intrinsic ability to sustain the activities of free-radical scavenging enzymes and the bioavailability of glutathione." | 1.36 | The role of erythropoietin in the protection of gastric mucosa from indometacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats. ( Albayrak, F; Albayrak, Y; Bayir, Y; Dursun, H; Halici, Z; Koc, F; Odabasoglu, F; Polat, B; Suleyman, H; Uyanik, A, 2010) |
| "Rats treated with indomethacin revealed mucosal hemorrhagic lesions, increased microvascular permeability and inhibited prostaglandin E₂ and mucus content." | 1.36 | Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E₂, nitric oxide and redox status in indomethacin-induced gastric ulcer model. ( El-Abhar, HS, 2010) |
| "The aspirin prodrug ( 23) was a 2." | 1.35 | Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies. ( Chen, QH; Citro, ML; Keefer, LK; Knaus, EE; Velázquez, CA, 2008) |
| "Pretreatment with irsogladine maleate markedly reduced the number and severity of these lesions in a dose-dependent manner." | 1.35 | Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats. ( Kageyama, K; Kyoi, T; Tajima, K; Zhang, X, 2008) |
| "Nicorandil pretreatment depicted a higher preventive index in indomethacin- (89." | 1.35 | Gastroprotective effect of nicorandil in indomethacin and alcohol-induced acute ulcers. ( Abdel-Hamid, NM; Abdel-Raheim, SR; El-Moselhy, MA, 2009) |
| "In indomethacin-treated animals, esomeprazole was more effective than famotidine or the antioxidant melatonin in promoting ulcer healing." | 1.35 | Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. ( Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M, 2009) |
| "Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that is limited in its enteral or parenteral use by side effects of gastroduodenal bleeding and ulceration." | 1.35 | Gastrointestinal safety and therapeutic efficacy of parenterally administered phosphatidylcholine-associated indomethacin in rodent model systems. ( Dial, EJ; Lichtenberger, L; Romero, JJ, 2009) |
| "Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent." | 1.35 | Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. ( Albayrak, F; Alp, HH; Bilici, M; Dursun, H; Ozturk, C; Saglam, MB; Suleyman, H, 2009) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 1.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "Indomethacin (IM) is a non-steroidal anti-inflammatory drug which inhibits prostaglandin biosynthesis." | 1.35 | Evaluation of gastric toxicity of indomethacin acid, salt form and complexed forms with hydroxypropyl-beta-cyclodextrin on Wistar rats: histopathologic analysis. ( Cabrita, AM; Caramona, MM; Castel-Branco, MM; Figueiredo, IV; Ribeiro-Rama, AC; Veiga, F, 2009) |
| "Indomethacin treatment was followed by severe injury to the gastric mucosa, decrease in proliferative activity of the epithelium, and stimulation of free-radical processes in gastric tissues." | 1.35 | Gastroprotective effect of dalargin in gastropathy due to treatment with nonsteroid antiinflammatory drugs. ( Fleishman, MY; Lebed'ko, OA; Sazonova, EN; Timoshin, SS; Zhivotova, EY, 2009) |
| " Administration of RBuOH at the same dosage (50, 100 and 200 mg/kg) reduced significantly (P<0." | 1.35 | Anti-ulcer, anti-inflammatory and antioxidant activities of the n-butanol fraction from Pteleopsis suberosa stem bark. ( Biasini, T; Braca, A; D'Angelo, V; De Leo, M; De Pasquale, R; Germanò, MP; Miano, TC; Sanogo, R, 2008) |
| "Gastric ulcers were induced in mice through serosal application of acetic acid." | 1.35 | Annexin-1 modulates repair of gastric mucosal injury. ( Flower, RJ; Martin, GR; Perretti, M; Wallace, JL, 2008) |
| "Acute gastrointestinal hemorrhage from a gastroaortic fistula in the gastric fundoplication pouch is a rare complication of Nissen fundoplication." | 1.35 | Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use. ( Depew, WT; Hurlbut, DJ; Manduch, M; Mercer, CD; Rossiter, JP, 2008) |
| "Indomethacin (IDM) was encapsulated in gelatin-cellulose acetate phthalate (CAP) microcapsules (A) by complex coacervation method and in CAP microcapsules (B) by simple coacervation method." | 1.34 | Sustained-release tablets of indomethacin-loaded microcapsules: preparation, in vitro and in vivo characterization. ( He, Y; Lu, B; Wen, R; Yang, H, 2007) |
| "When ticlopidine was administered 1h after EtOH, it significantly (p<0." | 1.34 | Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007) |
| "Acemetacin was rapidly converted to indomethacin after its administration." | 1.34 | Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin. ( Castañeda-Hernández, G; Chávez-Piña, AE; Dicay, M; McKnight, W; Wallace, JL, 2007) |
| "Spermine and taurine were able to decrease the elevated levels of gastric myeloperoxidase, conjugated diene, and serum NO." | 1.34 | Modulation of indomethacin-induced gastric injury by spermine and taurine in rats. ( Abd Elgawad, HM; Motawi, TK; Shahin, NN, 2007) |
| "Amiodarone is a widely used antiarrhythmic agent." | 1.34 | Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats. ( Bayir, Y; Cadirci, E; Dengiz, GO; Halici, Z; Odabasoglu, F; Suleyman, H, 2007) |
| "In indomethacin and rofecoxib-treated gerbils, the following results were obtained in H pylori-infected group vs H pylori-eradicated group respectively: hyperplasia area of the stomach (mm2): 82." | 1.33 | Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils. ( Chang, CC; Chen, SH; Fang, CL; Hsieh, CR; Lien, GS; Lou, HY; Pan, S, 2005) |
| "Indomethacin treatment dose-dependently reduced survivin protein levels and caused severe injury of gastric mucosa and RGM-1 cells." | 1.33 | Survivin: a novel target for indomethacin-induced gastric injury. ( Abdelkarim, B; Akahoshi, T; Chiou, SK; Jones, MK; Tanigawa, T; Tarnawski, AS, 2005) |
| "Indomethacin is a non-steroidal anti-inflammatory drug but its use is associated with high degree of gastric toxicity therefore it is prescribed only in severe conditions." | 1.33 | Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives. ( Amir, M; Kumar, S, 2005) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 1.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Pre-treatment with pioglitazone dose-dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% (ID50) being 10 mg/kg and 7 mg/kg, respectively." | 1.33 | Agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma): a new compound with potent gastroprotective and ulcer healing properties. ( Brzozowski, T; Burnat, G; Cieszkowski, J; Hahn, EG; Konturek, PC; Konturek, S; Kwiecień, SN; Pajdo, R; Pawlik, WW; Targosz, A, 2005) |
| "Acetic acid ulcers were produced in the rat gastric corpus; non-ulcer rats served as controls." | 1.33 | Cell proliferation in the gastric epithelium of the ulcer rat. ( Helander, HF; Li, H, 2005) |
| "Kolaviron pre-treatment 1 h before ulcer induction attenuated the HCl/ethanol reduction in CAT, SOD and GSH by 43%, 42% and 30%, respectively, and 67%, 68% and 64% following 72 h treatment with kolaviron." | 1.33 | Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed. ( Farombi, EO; Olaleye, SB, 2006) |
| "Gastric ulcer is a source of visceral pain." | 1.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| " However, a number of facts involving the occurrence of gastrointestinal lesions have limited the chronic use of NSAIDs." | 1.32 | Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine. ( Cardoso, LG; Carvalho, JC; Ferreira, LR; Maciel, HP; Perazzo, FF, 2004) |
| "Ketoconazole treatment resulted in significant protection against stress; indomethacin and ethanol induced gastric lesions in rats." | 1.32 | Protective effect of ketoconazole against experimentally induced gastric ulcers in rats. ( Al Moutaery, AR, 2003) |
| "Gastric ulcers were induced by abdominal injection of 0." | 1.31 | [Synthesis, preliminary antigastrelcosis activity and the protective effect on acute liver injury of zinc chlorin E4]. ( Liu, JF; Lu, JG; Wang, XY; Yao, JZ; Zhang, WN; Zhou, YJ; Zhu, J, 2001) |
| "Aspirin (500 mg/kg) was given by gavage and repeated 2." | 1.31 | Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats. ( Khuri, M; Mourad, FH; Nassar, CF; Shouaib, F, 2000) |
| " Pharmacodynamic evaluation of the liposomes was performed by carrageenan-induced rat paw edema (acute) and adjuvant arthritis (chronic) models." | 1.31 | Preparation and pharmacodynamic evaluation of liposomes of indomethacin. ( Diwan, PV; Srinath, P; Vyas, SP, 2000) |
| "Ebrotidine is a new H2 receptor antagonist that potentiates the gastric mucosal barrier." | 1.31 | Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine. ( Arroyo, MT; Lanas, A; Sáinz, R, 2000) |
| "Indomethacin has been shown to damage the villous microvasculature concomitant with alterations in villous blood flow in the rat." | 1.31 | Endothelial changes precede mucosal ulceration induced by indomethacin: an experimental study in the rat. ( Anthony, A; Kelly, D; Lewin, J; Piasecki, C; Pounder, RE; Wakefield, AJ, 2000) |
| "The indomethacin treatment of the premedicated animals with the drug hardly affected either the malondialdehyde (MDA) or superoxide dismutase (SOD) level in gastric tissue while the ulcerative agent itself significantly enhanced both the levels." | 1.31 | The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. ( Bandyopadhyay, SK; Pakrashi, A; Pakrashi, SC, 2000) |
| "Pretreatment with indomethacin did not influence the cytoprotective effect of rabeprazole." | 1.31 | Cytoprotective effect of rabeprazole against ethanol-induced gastric mucosal damage: possible involvement of nitric oxide. ( Arakawa, T; Fujiwara, Y; Higuchi, K; Tominaga, K; Watanabe, T, 2000) |
| "Pre-treatment with indomethacin significantly reduced the protective effect of the extract against HCl/ethanol solution to 31%." | 1.31 | Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats. ( Dimo, T; Dongo, E; Tan, PV, 2000) |
| "In vehicle-treated rats, gastric ulcers healed progressively and at day 14 the healing was completed, accompanied by a significant rise in the GBF at ulcer margin." | 1.31 | Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. ( Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z, 2001) |
| "Gastric ulcers were induced by a luminal application of acetic acid in male Donryu rats." | 1.31 | Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats. ( Amagase, K; Itoh, S; Nakai, H; Okabe, S; Tsukimi, Y, 2001) |
| "The effect of hyperprolactinaemia, induced by two or four pituitary homografts under the kidney capsule, on gastric and duodenal ulcers has been studied." | 1.31 | Effect of hyperprolactinaemia as induced by pituitary homografts under kidney capsule on gastric and duodenal ulcers in rats. ( Abraham, BK; Asad, M; Balasinor, N; Koumaravelou, K; Ramaswamy, S; Shewade, DG, 2001) |
| " Gastrointestinal ulceration was assessed, four hours after a single dose and 24 hours following the last dose of a chronic four day dosing regimen, by counting the number of lesions and ulcers present." | 1.30 | Comparative evaluation of the severity of gastric ulceration by solid dispersions and coprecipitates of indomethacin. ( Degennaro, MD; Karnachi, AA; Khan, MA; Reddy, IK, 1997) |
| " Male Sprague-Dawley rats were dosed with two doses of metronidazole (50 mg/kg, 12 and 1 h pre-NSAID) or a single 100 mg/kg dose of tempo 1 h prior to NSAIDs." | 1.30 | Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers. ( Davies, NM; Jamali, F, 1997) |
| "Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20 microliters of 20% acetic acid." | 1.30 | [A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump]. ( Katoh, Y; Kawashima, H; Tanaka, M, 1997) |
| "Pretreatment with glycine significantly protected animals against stress-, indomethacin- and necrotizing agents induced gastric lesions." | 1.30 | Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine. ( Al Moutaery, AR; Tariq, M, 1997) |
| "Pretreatment with indomethacin (10 mg kg[-1], s." | 1.30 | Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs. ( Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1997) |
| "Pretreatment with indomethacin to suppress endogenous PG reversed completely the protective and hyperemic effects of SU-840 against ethanol and stress induced damage whereas L-NNA, a potent inhibitor of NO-synthase, failed to affect protection but completely abolished the hyperemia evoked by this agent." | 1.30 | SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity. ( Brzozowski, T; Drozdowicz, D; Konturek, SJ; Kwiecien, S; Muramatsu, M; Pajdo, R; Sliwowski, Z, 1998) |
| "pretreatment with indomethacin at 5 mg/kg." | 1.30 | Protective role of melatonin and the pineal gland in modulating water immersion restraint stress ulcer in rats. ( Arakawa, Y; Asai, S; Ishikawa, K; Iwasaki, A; Kaneda, N; Kato, K; Komuro, S; Kuwayama, H; Matsuno, Y; Murai, I; Nakagawa, S, 1998) |
| "Indomethacin was administered orally in a dose-dependent manner at 10, 30, and 45 mg/ kg." | 1.30 | Naloxone is protective against indomethacin-induced gastric damage in cholestatic rats. ( Amanlou, M; Amanpour, S; Bahadori, M; Dehpour, AR; Mani, AR; Nahavandi, A, 1999) |
| "Lafutidine is a new type antiulcer agent with antisecretory and gastroprotective activities." | 1.30 | Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats. ( Aoyama, M; Arai, Y; Inaba, N; Nishizawa, A; Onodera, S; Sekine, Y; Shibata, M; Suzuki, T; Tanaka, M, 1999) |
| " CT-3 was devoid of GI ulceration when administered with DMSO either acutely at doses below 100 mg/kg or chronically at a dosage of 30 mg/kg/day for 5 days." | 1.30 | 1',1'-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: a novel, orally effective cannabinoid with analgesic and anti-inflammatory properties. ( Dajani, EZ; Dajani, NE; Dayton, MT; Larsen, KR; Mir, GN; Neeleman, SD; Shahwan, TG; Taylor, J; Taylor, MS, 1999) |
| "Atropine was given i." | 1.30 | Difference between the effect of acute and chronic surgical vagotomy on the cytoprotective action of atropine against indomethacin-induced mucosal lesions on the gastrointestinal tract in rats. ( Bódis, B; Karádi, O; Mózsik, G; Rumi, G; Szabó, I, 1999) |
| "Treatment with sulpiride (10-320 mg/kg, p." | 1.29 | Sulpiride specifically attenuates psychological stress-induced gastric lesions in rodents. ( Kuratani, K; Maeda, N; Nomura, K; Yamaguchi, I, 1995) |
| "Pretreatment with indomethacin, 10 mg/kg s." | 1.29 | Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins. ( Marhuenda, E; Martín, MJ; Pérez Guerrero, C, 1994) |
| "Naringin-treated rats showed a marked increase in hexosamine levels, but this increase was less in animals pretreated with indomethacin." | 1.29 | Antiulcer effect of naringin on gastric lesions induced by ethanol in rats. ( Franco, JM; Marhuenda, E; Martín, MJ; Pérez-Guerrero, C, 1994) |
| "Misoprostol treatment resulted in a significant reduction in the extent of indomethacin-induced antral ulceration, but ranitidine had no effect." | 1.29 | Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer. ( McKnight, GW; Wallace, JL, 1993) |
| "25 or 0h oral dosing of the 5-lipoxygenase inhibitor, MK-886, but not when only one of these doses was given." | 1.29 | Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage. ( Rainsford, KD, 1993) |
| "Gastric ulcers were produced 5 days after submucosal injection of 20% acetic acid (0." | 1.29 | Effect and mechanism of sucralfate on healing of acetic acid-induced gastric ulcers in rats. ( Ogihara, Y; Okabe, S, 1993) |
| "Indomethacin was associated with a time dependent increase in the extent and severity of ulceration, blood neutrophilia, neutrophil infiltration into the gastric antrum, and calcium ionophore induced immunoreactive leukotriene B4 (LTB4) release from the antrum ex vivo." | 1.29 | Do infiltrating neutrophils contribute to the pathogenesis of indomethacin induced ulceration of the rat gastric antrum? ( Clayton, NM; Harman, IW; Strong, P; Trevethick, MA, 1993) |
| " These results suggested that the bioavailability of IND was increased by olive oil, fatty acid, and tristearin as absorbefacient agents." | 1.29 | Pharmacological and pharmaceutical properties of freeze-dried formulations of egg albumin, indomethacin, olive oil, or fatty acids. ( Kakegawa, H; Matsumoto, H; Miyataka, H; Satoh, T; Tsuji, Y, 1993) |
| "The association between corticosteroid treatment and gastric ulcer healing is controversial." | 1.29 | Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers. ( Carpani de Kaski, M; Hodgson, HJ; Levi, S; Rentsch, R, 1995) |
| " Hourly dosing with hydrochloric acid reversed the protective effect of ranitidine, cimetidine and loxtidine on macroscopic damage and, histologically, this was associated with the widespread appearance of antral ulcers and a reduction in the proportion of mucosal damage caused by superficial erosions." | 1.29 | The role of acid in the pathogenesis of indomethacin-induced gastric antral ulcers in the rat. ( Clayton, NM; Oakley, I; Trevethick, MA; Williams, LV, 1996) |
| "Propranolol pretreatment in the highest dose (10 mg/kg) given either intraperitoneally (i." | 1.29 | A study of the antiulcer mechanisms of propranolol in rats. ( Cho, CH; Kaan, SK, 1996) |
| " The plasma levels of IM after the oral administration of IM-OE and IM-BE were comparatively low compared with those after IM, with a small bioavailability (2." | 1.29 | Pharmacokinetics of indomethacin ester prodrugs: gastrointestinal and hepatic toxicity and the hydrolytic capacity of various tissues in rats. ( Iwaki, M; Muraoka, O; Nagai, T; Ogiso, T; Tanabe, G; Tanino, T; Ueda, Y, 1996) |
| "Pretreatment with indomethacin (5 mg/kg i." | 1.28 | Studies on gastroprotection induced by capsaicin and papaverine. ( Brzozowski, T; Drozdowicz, D; Konturek, SJ; Majka, J, 1992) |
| " Thus, CP-331 exerted anti-inflammatory, analgesic, and antipyretic effects but without showing gastric toxicity, which is a common side effect of anti-inflammatory drugs." | 1.28 | Anti-inflammatory, analgesic, and antipyretic effects and gastrointestinal toxicity of the new anti-inflammatory drug N-(3-[3-(piperidinylmethyl)phenoxy]propyl)-carbamoylmethylthio ]ethyl 1-(p-chlorobenzoyl) 5-methoxy-2-methyl-3-indolylacetate. ( Abe, T; Itokazu, Y; Ohya, O; Omata, T; Segawa, Y; Tagashira, E; Tsuzuike, N; Ueda, I; Yoshida, K, 1992) |
| "Pretreatment with indomethacin (5 mg/kg intraperitoneally), which reduced mucosal generation of PGE2 by 85%, decreased in part the protection by TGF and EGF against ethanol-induced damage and virtually abolished the protective action of these peptides against stress-induced injury." | 1.28 | Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. ( Brzozowski, T; Dembinski, A; Konturek, SJ; Majka, J; Slomiany, A; Slomiany, BL, 1992) |
| "Pretreatment with indomethacin also reversed, in part, the protective and hyperemic effects of sucralfate but the combination of both indomethacin and L-NNA completely abolished these effects." | 1.28 | Role of nitric oxide and prostaglandins in sucralfate-induced gastroprotection. ( Brzozowski, T; Czarnobilski, K; Konturek, SJ; Majka, J, 1992) |
| " The absorption rate from alginate dispersions was enhanced in comparison with that from indomethacin alone, and enhanced only the rate of bioavailability in beagle dogs and volunteers." | 1.28 | Improvement of absorption rate of indomethacin and reduction of stomach irritation by alginate dispersions. ( Imai, T; Iwaoka, D; Otagiri, M; Shiraishi, S, 1991) |
| "Pretreatment with indomethacin significantly mitigated the protective effect of stress against ethanol injury." | 1.28 | Gastric mucosal protection induced by restraint and water-immersion stress in rats. ( Ishihara, T; Ohno, T; Uramoto, H, 1990) |
| "Pretreatment with indomethacin, to suppress mucosal generation of prostaglandins (PG), greatly augmented stress-induced gastric ulcerations and antagonized the protection exerted by both Solcoseryl and EGF." | 1.28 | Solcoseryl in prevention of stress-induced gastric lesions and healing of chronic ulcers. ( Bielański, W; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Pytko-Polonczyk, J, 1991) |
| " The pharmacokinetic profile of indomethacin nanocapsule formulations was compared to a solution of free drug following oral administration of 5 mg/kg in rats; no difference in the mean concentration-time profiles of the drug was observed." | 1.28 | Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d,l-lactide) and poly(isobutyl-cyanoacrylate) nanocapsules in rats. ( Ammoury, N; Benita, S; Devissaguet, JP; Dubrasquet, M; Fessi, H, 1991) |
| "All morphine effects were reversed by naloxone." | 1.28 | Antisecretory and anti-ulcer effects of morphine in rats after gastric mucosal aggression. ( Chariot, J; Del Tacca, M; Rozé, C; Tazi-Saad, K; Vatier, J, 1991) |
| "Aceclofenac is a new phenylacetic acid derivative provided with marked antiinflammatory, antiarthritic, analgesic and antipyretic activities in animal experimental models." | 1.28 | The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug. ( Carrasco, E; Felipe, A; Grau, M; Guasch, J; Juliá, S; Montero, JL, 1991) |
| "5." | 1.28 | Relationship between gastric mucosal prostaglandin levels and healing of gastric lesions in rats. ( Goto, H; Kuroiwa, M; Nakazawa, S; Ohara, A; Ozawa, T; Sugiyama, S; Tsukamoto, Y, 1990) |
| "Indomethacin pretreatment reversed these actions, whereas misoprostol administration produced the similar effects as 20% ethanol." | 1.28 | Endogenous prostaglandins: its role in gastric mucosal blood flow and ethanol ulceration in rats. ( Chen, BW; Cho, CH; Hui, WM; Lam, SK; Luk, CT, 1990) |
| "Treatment with dipyridamole replenish the reduced level of gastric mucosal nonprotein sulfhydryls, thus suggesting the mediation of its protective effect through sulfhydryls." | 1.28 | Gastric antiulcer and cytoprotective effects of dipyridamole in rats. ( Ageel, AM; Tariq, M, 1990) |
| "Indomethacin pretreatment did not significantly alter any of these findings." | 1.28 | Microscopic correlates of adaptive cytoprotection in an ethanol injury model. ( Miller, TA; Schmidt, KL; Smith, GS, 1989) |
| "Indomethacin is a potent and efficacious antiinflammatory agent." | 1.28 | Influence of indomethacin amphoteric gel on gastric ulcerogenicity and absorption of indomethacin in rats. ( Dent, J; Eickhoff, WM; Liversidge, GG, 1989) |
| "Pretreatment with ebselen at oral doses from 10 to 100 mg/kg significantly inhibited such lesion formation induced by either necrotizing agent in a dose-related manner, and the inhibition at the highest dose (100 mg/kg p." | 1.28 | Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats. ( Akasaki, M; Kurebayashi, Y; Tabuchi, Y, 1989) |
| "Gastric ulcers were induced by the submucosal injection of 20% acetic acid (0." | 1.28 | Effects of NC-1300, a gastric proton pump inhibitor, on healing of acetic acid-induced gastric ulcers in rats. ( Miyake, H; Okabe, S; Yamasaki, S, 1989) |
| " An increase in malondialdehyde level was observed after ethanol exposure, whereas suppression of lipid peroxidation occurred after dosing with indomethacin." | 1.28 | Lipid peroxidation in normal and ulcerated gastric mucosa of rats treated with pentacaine and cimetidine. ( Nosál, R; Nosálová, V; Petríková, M, 1989) |
| "Pretreatment with indomethacin (IND) had little influence on the cytoprotective effects of OGT and glutathione, but attenuated the effect of sucralfate." | 1.28 | A possible mechanism for the gastric mucosal protection by oren-gedoku-to (OGT), a traditional herbal medicine. ( Imanishi, K; Miura, O; Takase, H; Yumioka, E, 1989) |
| ") given 30 min prior to SU-88 dosing blocked this protective effect, whereas it was not affected when indomethacin was given 30 min after the SU-88 dosing." | 1.27 | Cytoprotective effect of SU-88, an anti-ulcer agent, in the rat. ( Kyogoku, K; Mori, Y; Nakazima, M; Shinozaki, A; Suwa, T, 1984) |
| " Moreover the gastric lesions in FCE 20700 + I treated rats were markedly reduced, allowing the dosage of I to be increased by about three times without increasing its ulcerogenic effect." | 1.27 | FCE 20700, a cytoprotective PGE2 derivative, does not interfere with the antiinflammatory activity of indomethacin. ( Arrigoni, C; Buttinoni, A; Ceserani, R; Ferrari, M; Mizzotti, B; Tremolada, L, 1983) |
| "If indomethacin was given intravenously either before or immediately after the first ethanol exposure, recovery of barrier function was significantly lessened after this challenge, and the resistance to barrier disruption was significantly decreased during the two subsequent exposures to ethanol when compared to experiments in which mucosa was exposed to 20% ethanol without concomitant administration of indomethacin." | 1.27 | Indomethacin decreases resistance of gastric barrier to disruption by alcohol. ( Henagan, JM; Miller, TA, 1984) |
| "aspirin were additive." | 1.27 | Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent. ( Holsapple, MP; Nichols, DE; Trizzino, J; Yim, GK, 1983) |
| "Indomethacin pretreatment (20 mg/kg, p." | 1.27 | Sulphasalazine and experimental stress ulcers. ( Cho, CH; Dai, S; Ogle, CW, 1985) |
| "Pretreatment with indomethacin (8 mg/kg intraperitoneally) abolished the effects of the 10% linoleic acid diet on prostaglandin formation, acid secretion, and mucosal injury." | 1.27 | Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: effects on gastric acid secretion and stress-induced mucosal damage. ( Classen, M; Ruoff, HJ; Schepp, W; Schusdziarra, V; Steffen, B, 1988) |
| "Indomethacin pretreatment (10 mg/kg p." | 1.27 | Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions. ( Barnett, A; Brown, AD; Chiu, PJ; Gerhart, C; Siegel, M, 1988) |
| "Morphine has been shown to produce a significant potentiation of indomethacin-induced gastric lesions in rats." | 1.27 | Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1987) |
| "Pretreatment with indomethacin partially reduced the protective effect of sucralfate." | 1.27 | Role of mucus and prostaglandins in the gastric mucosal protective actions of sucralfate against ethanol-induced injury in the rat. ( Quadros, E; Ramsamooj, E; Wilson, DE, 1987) |
| "Cimetidine, which was used as a standard antiulcer drug for comparison, also produced a similar protective effect in most of the models used by us." | 1.27 | Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1987) |
| " Oral dosing with U46619 or AH23848 produced a dose-related inhibition of ethanol-induced gastric mucosal damage in the conscious rat, and these effects were partially blocked by indomethacin treatment." | 1.27 | The effects of the stable thromboxane A2-mimetic, U46619, on gastric mucosal damage and gastric non-parietal secretion in the rat. ( Bunce, KT; Clayton, NM, 1987) |
| "Indomethacin co-treatment attenuated the reduction of ulcer formation of both pretreatments." | 1.27 | Evidence of "cross-stressor"-induced adaptive gastric cytoprotection. ( Glavin, GB; Hall, AM; Kiernan, KM; Lockhart, LK; Rockman, GE, 1987) |
| "Indomethacin pretreatment did not significantly augment the duodenal lesions induced by mepirizole or cysteamine, but did augment the gastric lesions induced by these compounds." | 1.27 | Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin. ( Kuwahara, Y; Okabe, S; Tanaka, H, 1986) |
| "Marked gastric ulcers were induced by indomethacin and diclofenac, and severe intestinal ulcers were also produced at 24 h and by their repeated administration." | 1.27 | Ulcerogenic and antiulcerogenic effects of a new antiinflammatory drug, the gamma-lactone-N-ethyl derivative of 6-[1S-(3S,4-dihydro-8-hydroxy-1H-2-benzo- pyran-1-one-3-yl)-3-methylbutylamino]-4S,5S-dihydroxy-6-oxo-3S- ammoniohexanoate, on gastrointestinal ( Kasuya, Y; Urushidani, T; Yano, S, 1986) |
| "pretreatment with indomethacin (5 mg/kg, s." | 1.27 | Cytoprotective effects of NC-1300 and omeprazole on Hcl . ethanol-induced gastric lesions in rats. ( Awane, Y; Miyake, H; Okabe, S, 1986) |
| "Salicylic acid has been shown to decrease gastric mucosal lesions induced by indomethacin in the rat." | 1.27 | Salicylic acid blocks indomethacin-induced cyclooxygenase inhibition and lesion formation in rat gastric mucosa. ( Elashoff, J; Guth, PH; Hansen, D; Kauffman, GL; Ligumsky, M; Paulsen, G, 1985) |
| "indomethacin) have been explored as a means for reducing the gastric ulcerogenicity of the latter." | 1.27 | Structural damage and changes in eicosanoid metabolites in the gastric mucosa of rats and pigs induced by anti-inflammatory drugs of varying ulcerogenicity. ( Rainsford, KD, 1986) |
| "Indomethacin pretreatment antagonized sodium benzoate-ulcer reducing properties indicating that this latter acts, at least in part, through stimulation of prostaglandins synthesis." | 1.27 | Influence of antioxidants and radical scavengers on ethanol-induced gastric ulcers in the rat. ( Evangelista, S; Meli, A, 1985) |
| "possessed useful properties in the treatment of gastric ulcers." | 1.27 | Experimental anti-ulcer activity of Veronica officinalis L. extracts. ( Cuparencu, B; Sandor, V; Scarlat, M; Tămaş, M, 1985) |
| "Nabumetone is a compound of novel structure which displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs." | 1.26 | Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent. ( Boyle, EA; Freeman, PC; Mangan, FR; Thomson, MJ, 1982) |
| " Indomethacin--in the same test--was 37 times more potent than A-162-ester and the PGI2 inhibition and ulcerogenic dose-response curves for indomethacin were parallel." | 1.26 | A new anti-inflammatory derivative of imidazole which is less ulcerogenic than indomethacin in rats. ( Corell, T; Jensen, KM; Splawinski, J, 1979) |
| " The degree of gastric or intestinal irritation seen with dosing of other drugs was as follows; indomethacin greater than diclofenac Na greater than ibuprofen greater than aspirin greater than phenylbutazone or indomethacin greater than CH-800 = diclofenac Na greater than ibuprofen greater than phenylbutazone, respectively." | 1.26 | [Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)]. ( Ohtsuki, H; Okabe, S; Tabata, K, 1979) |
| " In animals pretreated by anti-inflammatory drugs in toxic doses an earlier development of ulceration was observed by distention with acid." | 1.26 | Distention ulcer as a model for testing of drugs for ulcerogenic side effects. ( Szelenyi, I; Thiemer, K, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 329 (27.42) | 18.7374 |
| 1990's | 279 (23.25) | 18.2507 |
| 2000's | 269 (22.42) | 29.6817 |
| 2010's | 250 (20.83) | 24.3611 |
| 2020's | 73 (6.08) | 2.80 |
| Authors | Studies |
|---|---|
| Ackrell, J | 1 |
| Antonio, Y | 1 |
| Franco, F | 1 |
| Landeros, R | 1 |
| Leon, A | 1 |
| Muchowski, JM | 1 |
| Maddox, ML | 1 |
| Nelson, PH | 1 |
| Rooks, WH | 1 |
| Roszkowski, AP | 1 |
| Wallach, MB | 1 |
| Nagakura, M | 1 |
| Ota, T | 1 |
| Shimidzu, N | 1 |
| Kawamura, K | 1 |
| Eto, Y | 1 |
| Wada, Y | 1 |
| Yoshioka, Y | 1 |
| Kitagawa, M | 1 |
| Oki, M | 1 |
| Kubo, S | 2 |
| Tagawa, H | 2 |
| Ueno, K | 2 |
| Tsukada, W | 2 |
| Tsubokawa, M | 1 |
| Kasahara, A | 1 |
| Yoshioka, T | 1 |
| Asselin, AA | 1 |
| Humber, LG | 2 |
| Dobson, TA | 1 |
| Komlossy, J | 1 |
| Martel, RR | 1 |
| Demerson, CA | 1 |
| Philipp, AH | 1 |
| Safak, C | 1 |
| Erdogan, H | 1 |
| Palaska, E | 1 |
| Sunal, R | 1 |
| Duru, S | 1 |
| Ikuta, H | 2 |
| Shirota, H | 2 |
| Kobayashi, S | 2 |
| Yamagishi, Y | 3 |
| Yamada, K | 3 |
| Yamatsu, I | 2 |
| Katayama, K | 2 |
| Toja, E | 1 |
| Selva, D | 3 |
| Schiatti, P | 3 |
| Nagai, Y | 1 |
| Irie, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Study of Orally Administrated JBM-TC4 for the Prevention of Acute Radiation-induced Dermatitis in Breast Cancer Patients[NCT02289365] | Phase 2 | 120 participants (Actual) | Interventional | 2014-11-30 | Enrolling by invitation | ||
| Effects of Lavender Aromatherapy and Cold Application on Pain During Drain Removal[NCT04798040] | 121 participants (Actual) | Interventional | 2021-09-01 | Completed | |||
| Elderly Patients With Dementia in the Department of Acute Geriatrics: Pilot Study, Monocentric, Randomized Use of Aromatherapy as a Complementary Treatment to Psychopharmacotherapy in Psychological Disorders and BPSD Behavior[NCT03662360] | 32 participants (Actual) | Interventional | 2018-05-20 | Completed | |||
| A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients[NCT01837966] | 93 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Rebamipide Ophthalmic Suspension in the Treatment of Dry Eye: A Multicenter, Phase 3, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, 52 Week Study[NCT00201981] | Phase 3 | 740 participants (Anticipated) | Interventional | 2004-05-31 | Completed | ||
| Efficacy of Zinc L-carnosine (Hepilor®) in Maintaining Remission of Gastroesophageal Reflux Disease: a Randomised, Double-blind, Placebo-controlled Study[NCT03467438] | Phase 4 | 80 participants (Anticipated) | Interventional | 2018-11-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Neuropsychiatric Inventory - Nursing Home Version (NPI-NH) test will characterize the neuropsychiatric and psychopathological symptoms of patients affected by dementia.~Events as delirium, anxiety, depression, etc. will be recorded by the frequency (from 0, absence, to 4, high frequency) and the seriousness (from 0, absence, to 3, high). The total score of the NPI-NH is given by the frequency x (multiply) seriousness (total score for each event has a range from 0 to 12). The patient final score will be given by the sum of the score of the 12 events. For each patient will be given a total score from 0 to 144.~NPI NH score has been collected in both control and aromatherapy groups at T1 and T3, in patients who needed and who did not needed Pro Re Nata." (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| T1 NPI score in patients do not need Pro Re Nata | T3 NPI score in patients needed Pro Re Nata | T3 NPI score in patients do not need Pro Re Nata | |
| GROUP A - Control Group | 21.81 | 32.87 | 20.00 |
| GROUP B - Aromatherapy Group | 25.93 | 16.5 | 7.25 |
NPI-NH assess the psychological distress in physicians, nurses and nursing assistants who managed the patients. It has a score from 0 (no discomfort) to score of 5 (extreme discomfort). The psychological distress is measured for each of the 12 events in the NPI-NH scale, for a total score from 0 to 60. (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)
| Intervention | score on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T1 NPI NH physicians in pts with PRN | T1 NPI NH physicians in pts without PRN | T1 NPI NH nurses in pts with PRN | T1 NPI NH nurses in pts without PRN | T1 NPI NH nursing assistants in pts with PRN | T1 NPI NH nursing assistants in pts without PRN | T3 NPI NH physician in pts with PRN | T3 NPI NH physician in pts without PRN | T3 NPI NH nurses in pts with PRN | T3 NPI NH nurses in pts without PRN | T3 NPI NH nursing assistants in pts with PRN | T3 NPI NH nursing assistants in pts without PRN | |
| GROUP A - Control Group | 4.19 | 1.60 | 9.63 | 6.40 | 11.00 | 7.10 | 6.00 | 3.20 | 12.00 | 9.30 | 13.19 | 9.90 |
| GROUP B - Aromatherapy Group | 5.64 | 4.13 | 11.64 | 10.13 | 12.21 | 10.88 | 2.64 | 0.88 | 5.79 | 4.25 | 5.93 | 4.38 |
We hoped to show that lavender aroma therapy reduces preoperative anxiety in patients undergoing breast. The Trait subscale (STAI-TRAID) of the Spielberger State-Trait Anxiety Inventory was administered before and after 10 minutes of aromatherapy treatment pre-surgery. The TRAIT subscale contains 20 questions scored on a Likert scale from 1-4; item scores are summed for a total score ranging from 20 to 80, with higher scores indicating higher anxiety. Change in anxiety was calculated as the score pre-aromatherapy minus the score post-aromatherapy. Higher positive change scores indicate greater reductions in anxiety. (NCT01837966)
Timeframe: 20 minutes before surgery (pre aromatherapy) and 10 minutes before surgery (post aromatherapy)
| Intervention | units on a scale (Mean) |
|---|---|
| Lavender Oil | 0.89 |
| Placebo | .74 |
17 reviews available for indomethacin and Stomach Ulcer
| Article | Year |
|---|---|
Gastroprotective Role of Fruit Extracts in Gastric Damage Induced by Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Fruit; G | 2023 |
[Free Radical Production and Production Mechanism in the Early and Advanced Stages of Gastrointestinal Lesions].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dextran Sulfate; Electron Spin Resonance | 2020 |
[Gastroprotective role of glucocorticoid hormones during action of nonsteroidal anti-inflammatory drugs].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Gastric Mucosa; Glucocorticoids; Hu | 2009 |
Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bicarbonates; Cyclooxygenase In | 2010 |
[Novel pharmacological effects of NSAIDs and their molecular mechanism].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2012 |
[Changes in ulcerogenic response to non-steroidal antiinflammatory drugs (NSAIDs) in the gastrointestine during chronic arthritis].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cy | 2006 |
Compensatory gastroprotective role of glucocorticoid hormones during inhibition of prostaglandin and nitric oxide production and desensitization of capsaicin-sensitive sensory neurons.
Topics: Adrenalectomy; Animals; Capsaicin; Corticosterone; Gastric Mucosa; Glucocorticoids; Indomethacin; Ne | 2007 |
Drug therapy: nonsteroidal antiinflammatory drugs (first of two parts).
Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Child; Drug Tolerance; Female; Gastric Mucosa; Gastrit | 1980 |
Non-steroidal anti-inflammatory drug-induced gastric damage in experimental animals: underlying pathological mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cricetinae; Gastric Acid; Histamine H2 Antagonists | 1995 |
Selective cyclooxygenase-2 inhibitors as potential therapeutic agents for inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2 | 1997 |
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils].
Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer | 2001 |
Role of cyclooxygenase-2 in gastric mucosal defense.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2001 |
[Mechanism of the ulcerogenic effects of phenylbutazone and indomethacin].
Topics: Adrenalectomy; Animals; Female; Gastric Juice; Gastric Mucosa; Guinea Pigs; Histidine Decarboxylase; | 1978 |
The role of the mucosal barrier in drug-induced gastric ulceration and erosions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ethanol; Gastric Juice; Gastric Mucosa; | 1976 |
Analgesics and the stomach.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Indometha | 1976 |
[Effect of some drugs in the development and exacerbation of gastric and duodenal ulcer].
Topics: Adrenocorticotropic Hormone; Aspirin; Caffeine; Catecholamines; Duodenal Ulcer; Fluorouracil; Glucoc | 1974 |
[Effect of some antirheumatic agents on the gastric mucous membrane].
Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma | 1971 |
12 trials available for indomethacin and Stomach Ulcer
| Article | Year |
|---|---|
Gastroprotective effect of topiramate on indomethacin-induced peptic ulcer in rats: Biochemical and histological analyses.
Topics: Animals; Antioxidants; Indomethacin; Ranitidine; Rats; Stomach Ulcer; Superoxide Dismutase; Topirama | 2022 |
Gastric microbleeding measurements during one day treatment with indomethacin and indomethacin plus sodium salicylate (1 : 10) in patients.
Topics: Adult; Double-Blind Method; Drug Combinations; Female; Gastric Juice; Gastric Mucosa; Hemoglobinomet | 1984 |
Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation.
Topics: Adult; Anti-Inflammatory Agents; Capsules; Drug Evaluation; Female; Gastric Mucosa; Gastrointestinal | 1983 |
Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheu | 1993 |
Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cimetidine; Cross-Over S | 1997 |
Studies on the protective effect of ebrotidine on experimental ulcers induced by non-steroidal anti-inflammatory drugs in healthy volunteers.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Carbonic Anhydrases; Female | 1997 |
Reduction of non-steroidal anti-inflammatory drug induced gastric injury and leucocyte endothelial adhesion by octreotide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Double-Blind Method; Endothelium, V | 1997 |
Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study.
Topics: Adult; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytokines; | 1998 |
[Therapy of gastric and duodenal ulcer with Metoclopramide].
Topics: Aged; Clinical Trials as Topic; Duodenal Ulcer; Female; Humans; Indomethacin; Male; Metoclopramide; | 1976 |
A comparison of upper gastrointestinal mucosal damage by standard and delayed-release indomethacin.
Topics: Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Double-Blind Method; Duodenal Ulcer; Du | 1992 |
Prevention of non-steroidal anti-inflammatory agents induced acute gastric mucosal lesions by carbonic anhydrase inhibitors. An endoscopic study.
Topics: Acetazolamide; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastroscopy; | 1989 |
[Stomach tolerance of nonsteroidal antirheumatic drugs: comparative endoscopic study].
Topics: Adult; Alprostadil; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspiri | 1987 |
1171 other studies available for indomethacin and Stomach Ulcer
| Article | Year |
|---|---|
Synthesis and antiinflammatory activity of 6,11-dihydro-11-oxodibenzo[b,e]thiepinalkanoic acids and related compounds.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exp | 1978 |
Syntheses and antiinflammatory actions of 4,5,6,7-tetrahydroindazole-5-carboxylic acids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Edema; Indazole | 1979 |
Nonsteroidal antiinflammatory agents. 2. Derivatives/analogues of dibenz[b,e]oxepin-3-acetic acid.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dibenzoxepins; Edema; Lethal Dose 50; Male; Rats; St | 1978 |
6,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dibenzoxepins; Edema; Female; Le | 1976 |
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes; | 1976 |
Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent di- and trisubstituted 1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acids.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Freund's Adjuvant; Indoleacet | 1976 |
Synthesis of 3-(2-pyridylethyl)benzoxazolinone derivatives: potent analgesic and antiinflammatory compounds inhibiting prostaglandin E2.
Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 1992 |
Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylidene Compounds; Cyclooxygenase Inhibitors; | 1987 |
3-Alkyl-2-aryl-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Evaluation, Preclini | 1984 |
Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, E | 1982 |
2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzofurans; Cattle; Chemical Phenomena; | 1981 |
Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides).
Topics: Animals; Arthritis, Experimental; Edema; Glycerides; Indomethacin; Male; Rats; Stomach Ulcer; Struct | 1980 |
Synthesis and biological activity of 5-(4-chlorobenzoyl)-4-(hydroxymethyl)-1-methyl-1H-pyrrole-2-acetic acid, a major metabolite of zomepirac sodium.
Topics: Analgesics; Animals; Arthritis, Experimental; Humans; In Vitro Techniques; Platelet Aggregation; Pyr | 1980 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cycl | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan | 1999 |
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
Topics: Adult; Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge | 2004 |
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azo Compounds; Cyclooxygenase 1; Cyclooxy | 2005 |
Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Male; Naproxen; Propionat | 2007 |
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.
Topics: Analgesics; Anilides; Animals; Benzenesulfonates; Carrageenan; Colorimetry; Crystallography, X-Ray; | 2007 |
Preparation of 5-aryl-3-alkylthio-l,2,4-triazoles and corresponding sulfones with antiinflammatory-analgesic activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Mice; Molecular Structure; Stomach Ulcer; Sulfones; T | 2007 |
Synthesis, docking studies and anti-inflammatory activity of 4,5,6,7-tetrahydro-2H-indazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 2007 |
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cycloo | 2007 |
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Synergism; Female; Gastr | 2007 |
New celecoxib derivatives as anti-inflammatory agents.
Topics: Acetic Acid; Animals; Carrageenan; Celecoxib; Chronic Disease; Crystallization; Cyclooxygenase 1; Cy | 2008 |
Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azo Compounds; Carr | 2008 |
Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity.
Topics: Acetates; Acylation; Animals; Anti-Inflammatory Agents; Drug Design; Drug-Related Side Effects and A | 2009 |
Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.
Topics: Animals; Anti-Inflammatory Agents; Edema; Indomethacin; Male; Nitric Oxide; Pyrazoles; Rats; Referen | 2009 |
A new therapeutic approach in Parkinson's disease: some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Child, Preschool; Cyclic Nucleotide Phosphodiesterases, Type 1; D | 2009 |
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Edema; Est | 2011 |
Synthesis and biological evaluation of orally active prodrugs of indomethacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Stability; | 2011 |
Analogue-based design, synthesis and molecular docking analysis of 2,3-diaryl quinazolinones as non-ulcerogenic anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase I | 2011 |
Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Edema; Models, Mole | 2012 |
1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Edem | 2014 |
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.
Topics: Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxyg | 2014 |
Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclooxygenase 2; | 2014 |
Design, synthesis and biological evaluation of piperic acid triazolyl derivatives as potent anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Line; Cell Sur | 2015 |
Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates.
Topics: Animals; Anti-Inflammatory Agents; Indomethacin; Mesalamine; Metronidazole; Mice; Molecular Structur | 2015 |
Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls.
Topics: Abietanes; Animals; Anti-Ulcer Agents; Baccharis; Cell Line; Cell Survival; Gastric Juice; Gastric M | 2015 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cycloox | 2015 |
Gastroprotective activity of synthetic coumarins: Role of endogenous prostaglandins, nitric oxide, non-protein sulfhydryls and vanilloid receptors.
Topics: Animals; Anti-Ulcer Agents; Coumarins; Gastric Mucosa; Mice; Nitric Oxide; Prostaglandins; Stomach U | 2016 |
Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening.
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Anti-Inflammatory Agents; Drug Design; Rats; Rats, Wistar; | 2017 |
Synthesis, molecular docking and biological evaluation of some newer 2-substituted-4-(benzo[d][1,3]dioxol-5-yl)-6-phenylpyridazin-3(2H)-ones as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Cyclooxy | 2017 |
Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Benzimidazoles; C | 2017 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimet | 2018 |
Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2019 |
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonate 5-Lipoxygenase; Cyclo | 2020 |
Gastroprotective Effect of Enteral Nutrition Formula in Mice Injected Subcutaneously with Indomethacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Enteral Nutrition; Food, For | 2021 |
Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis.
Topics: Animals; Animals, Outbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apopt | 2022 |
Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation.
Topics: Acetic Acid; Animals; Anthocyanins; Antioxidants; Biomarkers; Cyclooxygenase 1; Disease Models, Anim | 2021 |
Gastroprotective Effects of
Topics: Actinidia; Animals; Anti-Ulcer Agents; Disease Models, Animal; Fruit; Gastric Mucosa; Indomethacin; | 2021 |
Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biologica | 2021 |
Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies.
Topics: Alanine; Animals; Biological Availability; Biological Products; Carrageenan; Chemical Engineering; C | 2021 |
Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation.
Topics: Animals; Antioxidants; Arginase; bcl-2-Associated X Protein; Caspase 3; Cyclooxygenase 2; Flavonoids | 2022 |
Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade.
Topics: Animals; Down-Regulation; Indomethacin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matr | 2022 |
Role of ADMA/DDAH-1 and iNOS/eNOS signaling in the gastroprotective effect of tadalafil against indomethacin-induced gastric injury.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Indomethacin; Nitric Ox | 2022 |
AMPK/mTOR-driven autophagy & Nrf2/HO-1 cascade modulation by amentoflavone ameliorates indomethacin-induced gastric ulcer.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Biflavonoids; Gastric Mucosa; Indomethacin; Male; | 2022 |
Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Apoptosis; Caspase 3; Cholinergic Agents; Glutathi | 2022 |
The effects of dragon fruit (Hylocereus polyrhizus) extract on indomethacin-induced stomach ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; bcl-2-Associated | 2022 |
Role of LTB4 and nitric oxide in the gastroprotective effect of
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Gastric Mucosa; Indomethacin; Leukotriene B4; Nitric Oxide | 2023 |
The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; DNA Nucleotidylexotransferase; Ethanol; Gastric Mucosa; In | 2022 |
Therapeutic Versus Preventative Use of
Topics: Animals; Cyclooxygenase 2; Cytokines; Ginkgo biloba; Indomethacin; Mice; Plant Extracts; Proliferati | 2022 |
RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Cytokines; Indomethacin; Interleukin-6; M | 2022 |
Cembranoids from the Red Sea soft coral Sarcophyton glaucum protect against indomethacin-induced gastric injury.
Topics: Animals; Anthozoa; Antioxidants; Diterpenes; Indian Ocean; Indomethacin; Rats; Stomach Ulcer; Transf | 2023 |
Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration.
Topics: Animals; bcl-2-Associated X Protein; Caco-2 Cells; Chlorogenic Acid; Dinoprostone; Humans; Indometha | 2023 |
Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1.
Topics: Animals; Indomethacin; Rats; Stomach Ulcer; Tumor Necrosis Factor-alpha; Ulcer; Vitamin K 1 | 2023 |
Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats.
Topics: Animals; Cyclooxygenase 2; Cytokines; Famotidine; Gastric Mucosa; Gastritis; HSP70 Heat-Shock Protei | 2023 |
Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves.
Topics: Adenosine Triphosphate; Animals; Anti-Ulcer Agents; Apigenin; Bignoniaceae; Ethanol; Gastritis; Indo | 2023 |
Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats.
Topics: Animals; Carbon Monoxide; Cyclooxygenase 2; Gastric Mucosa; Indomethacin; NF-E2-Related Factor 2; Ra | 2023 |
The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats.
Topics: Animals; Cyclooxygenase 2; Cytokines; Gastric Mucosa; Indomethacin; Juglans; Oligopeptides; Rats; St | 2023 |
Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis.
Topics: Aesculus; Animals; Antioxidants; Glutathione; Indomethacin; Phytochemicals; Plant Extracts; Prostagl | 2023 |
Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats.
Topics: Animals; Gastrointestinal Microbiome; Indomethacin; Medicine, Mongolian Traditional; Metabolomics; R | 2023 |
Effect of felodipine on indomethacin-induced gastric ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Famotidine; Felodipine; Indomethacin | 2023 |
Gastro-protective effect of l-arginine against nitric oxide deficiency-related mucosal injury induced by indomethacin: Does age matter?
Topics: Animals; Arginine; Dinoprostone; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ra | 2023 |
Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cytokines; Ethanol; Indomethacin; Mice; Models, Theoretica | 2024 |
Protective effect of Lizhong Pill on nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rats: Possible involvement of TNF and IL-17 signaling pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Gastric Mucosa; Indomethacin; Interleuk | 2024 |
Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Apomorphine; Atropine; Bile Reflux; C | 2023 |
Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Cytokines; Gastric Mucosa; Indom | 2024 |
Flavonoid-Rich
Topics: Animals; Antioxidants; Flavonoids; Fruit; Glutathione; Indomethacin; Inflammation; NF-E2-Related Fac | 2023 |
Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach.
Topics: Achillea; Animals; Anti-Ulcer Agents; Humans; Indomethacin; Male; Metabolomics; Plant Extracts; Prot | 2019 |
Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cell Transdifferentiation; Cul | 2019 |
Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids.
Topics: Administration, Oral; Aminosalicylic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachid | 2020 |
Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Dipeptides; Gastric Mucosa; Humans; | 2019 |
Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enteral Nutrition; Food, Formulated; Gastric Mucos | 2019 |
Total triterpenes from the fruits of Chaenomeles speciosa (Sweet) Nakai protects against indomethacin-induced gastric mucosal injury: involvement of TFF1-mediated EGF/EGFR and apoptotic pathways.
Topics: Animals; Apoptosis; Caspase 3; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Epiderma | 2020 |
Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment.
Topics: Animals; Anti-Ulcer Agents; Centella; Drug Delivery Systems; Drug Liberation; Gastric Mucosa; Indome | 2020 |
Total triterpenoids from the fruits of Chaenomeles speciosa exerted gastroprotective activities on indomethacin-induced gastric damage via modulating microRNA-423-5p-mediated TFF/NAG-1 and apoptotic pathways.
Topics: Animals; Apoptosis; Fruit; Growth Differentiation Factor 15; Humans; Indomethacin; Male; MicroRNAs; | 2020 |
Evaluating the mucoprotective effect of polydeoxyribonucleotide against indomethacin-induced gastropathy via the MAPK/NF-κB signaling pathway in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Indomethacin; Male; Mitogen-Activa | 2020 |
Agomelatine prevents indomethacin-induced gastric ulcer in rats.
Topics: Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relat | 2020 |
Effects of stress preconditioning on vulnerability of gastric and small intestinal mucosa to ulcerogenic action of indomethacin in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Corticosterone; Gastric Mucosa; Indomethacin; Inte | 2019 |
The prospective curative role of lipoxin A
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Lipoxins; | 2020 |
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dual Oxidases; Duloxetine Hydrochloride; Gas | 2020 |
Proton Pump Inhibitors Prevent Gastric Antral Ulcers Induced by NSAIDs via Activation of Capsaicin-Sensitive Afferent Nerves in Mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Disease Models, Animal; Gastric Emptyin | 2020 |
Synthesis of novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives as cyclooxygenase-2 inhibitors.
Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Female; | 2020 |
Anti-inflammatory, antioxidant, and gaso-protective mechanism of 3α-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Dinoprostone; Disease Models, An | 2020 |
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats.
Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artesunate; Drug Therapy, Combination; Gastric Muco | 2020 |
Pumpkin Oil-Based Nanostructured Lipid Carrier System for Antiulcer Effect in NSAID-Induced Gastric Ulcer Model in Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cucurbita; Disease Models, Animal; Drug Carriers; | 2020 |
Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway.
Topics: Animals; Anti-Ulcer Agents; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Gastric Mucosa | 2020 |
LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats.
Topics: Amides; Animals; Famotidine; Gene Expression; Indomethacin; Male; Nitric Oxide Synthase Type III; Ph | 2020 |
Optimized Ellagic Acid-Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats.
Topics: Animals; Disease Models, Animal; Ellagic Acid; Indomethacin; Male; Oxidative Stress; Particle Size; | 2020 |
Cytoprotective and antisecretory properties of methanolic extract of
Topics: Animals; Anti-Ulcer Agents; Caesalpinia; Cryoprotective Agents; Disease Models, Animal; Ethanol; Gas | 2020 |
Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Humans; Indomethacin; L | 2022 |
Involvement of nitric oxide pathway in the anti-inflammatory effect of modafinil on indomethacin-, stress-, and ethanol -induced gastric mucosal injury in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Stimulants; Cytokines; Etha | 2020 |
Gastroprotective and cicatrizing activity of the Ziziphus joazeiro Mart. leaf hydroalcoholic extract.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Female; Gastric Mucosa; Indomethacin; M | 2020 |
Nerolidol-beta-cyclodextrin inclusion complex enhances anti-inflammatory activity in arthritis model and improves gastric protection.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arthritis; Arthritis, Experimental; beta-Cyclo | 2021 |
New indomethacin analogs as selective COX-2 inhibitors: Synthesis, COX-1/2 inhibitory activity, anti-inflammatory, ulcerogenicity, histopathological, and docking studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Cyclooxygenase 1; | 2021 |
The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Metformin; N | 2021 |
Possible protective effect of TNF-α inhibition and triad NO/cGMP/VEGF activation on gastric ulcer in rats.
Topics: Animals; Cyclic GMP; Dinoprostone; Indomethacin; Male; Malondialdehyde; Nitric Oxide; Pentoxifylline | 2021 |
Efficacy of a Chitosan-curcumin Mixture in Treating Indomethacininduced Acute Gastric Ulcer in Rats.
Topics: Animals; Anti-Ulcer Agents; Chitosan; Curcumin; Gastric Mucosa; Indomethacin; Rats; Stomach Ulcer | 2021 |
Obesity-associated up-regulation of lipocalin 2 protects gastric mucosa cells from apoptotic cell death by reducing endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Endoplasmic Retic | 2021 |
Protective and therapeutic effects of the flavonoid "pinocembrin" in indomethacin-induced acute gastric ulcer in rats: impact of anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Apoptosis; Flavanones; Flavonoid | 2021 |
Influence of forced treadmill and voluntary wheel running on the sensitivity of gastric mucosa to ulcerogenic stimuli in male rats.
Topics: Animals; Cold Temperature; Corticosterone; Gastric Mucosa; Indomethacin; Male; Physical Conditioning | 2020 |
Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling.
Topics: Animals; Apoptosis; Autophagy; Chlorogenic Acid; Gastric Mucosa; Indomethacin; Male; Proto-Oncogene | 2021 |
Anti-ulcerogenic effect of methanolic extract of Elaeagnus conferta Roxb. seeds in Wistar rats.
Topics: Animals; Anti-Ulcer Agents; Body Weight; Catalase; Elaeagnaceae; Gastric Mucosa; Glutathione; Hydrog | 2021 |
Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Biomarkers; Goblet Cells; | 2021 |
Attenuating Effect of Telfairia occidentalis on Oxidative Stress in Indomethacin-induced Gastric Ulcer in Male Rats.
Topics: Animals; Anti-Ulcer Agents; Gastric Mucosa; Indomethacin; Male; Oxidative Stress; Plant Extracts; Ra | 2020 |
Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats.
Topics: Animals; Anti-Ulcer Agents; Apoptosis; Caspase 3; Esomeprazole; Female; Heme Oxygenase-1; Humans; In | 2021 |
Evaluation of the Gastroprotective Effect of the Flavonoid Complex from Lychnis chalcedonica L. on the Models of Experimental Ulcerogenesis.
Topics: Animals; Animals, Outbred Strains; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Ethano | 2021 |
Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing.
Topics: Acanthaceae; Acetic Acid; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Res | 2021 |
Gastroprotective Activities of Ethanol Extract of Black Rice Bran (
Topics: Animals; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Indomethacin; Male; Oryza; Phytotherapy; Plant | 2021 |
A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase 2; Dinoprostone; | 2021 |
Combined Effects of Medicinal Plants on Induced Upper Gastrointestinal Tract Injury in Wistar Rats.
Topics: Aloe; Animals; Brassica; Dose-Response Relationship, Drug; Duodenal Ulcer; Female; Garlic; Indometha | 2016 |
Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Indomethacin; Inflammation; NF-E2-Relat | 2017 |
Gastroprotective and Antiulcer Effects of Celastrus paniculatus Seed Oil Against Several Gastric Ulcer Models in Rats.
Topics: Animals; Celastrus; Disease Models, Animal; Ethanol; Female; Gastric Acidity Determination; Gastric | 2018 |
Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome.
Topics: Animals; Carrageenan; Cytoprotection; Female; Indomethacin; Naphthoquinones; Polysaccharides; Rats, | 2017 |
Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Disease Models, A | 2018 |
Silver oxide nanoparticles alleviate indomethacin-induced gastric injury: a novel antiulcer agent.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antio | 2018 |
Chrysophyllum cainito (apple-star): a fruit with gastroprotective activity in experimental ulcer models.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Female; Fruit; Gastric Mucosa; Indometh | 2019 |
Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Cyclooxygenase 1; Cyclooxygenase 2; Dise | 2018 |
Healing and Antisecretory Effects of Aqueous Extract of
Topics: Acanthaceae; Acetic Acid; Animals; Antioxidants; Disease Models, Animal; Gastric Mucosa; Humans; Ind | 2017 |
Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury.
Topics: 2-Propanol; Animals; Anti-Ulcer Agents; Artemisia; Dogs; Ethanol; Flavonoids; Gastric Mucosa; Indome | 2017 |
Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis.
Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; D | 2018 |
Zinc salt enhances gastroprotective activity of risperidone in indomethacin-induced gastric ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chlorides; Dopamine Antagonists; Drug Synergism; I | 2016 |
Lysophosphatidic acid in medicinal herbs enhances prostaglandin E
Topics: Animals; Cell Death; Cell Proliferation; Dinoprostone; Indomethacin; Lysophospholipids; Mice; Plants | 2018 |
Antioxidant and anti-inflammatory activities of alpha lipoic acid protect against indomethacin-induced gastric ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Indomethacin; Male; Nitric Oxide Synthase Type II; | 2018 |
In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging.
Topics: Animals; Cyclic N-Oxides; Indomethacin; Magnetic Resonance Spectroscopy; Male; Molecular Imaging; Ni | 2019 |
Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cordia; Indomethacin; Inflammation Medi | 2018 |
Combination therapy with polydeoxyribonucleotide and proton pump inhibitor enhances therapeutic effectiveness for gastric ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Indomethacin; Male; Pol | 2018 |
Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats.
Topics: Animals; Gastric Mucosa; Indomethacin; Liver; Male; Plant Extracts; Plantago; Protective Agents; Rat | 2018 |
Oil from the fruits of Pterodon emarginatus Vog.: A traditional anti-inflammatory. Study combining in vivo and in silico.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Croton Oil; Cyclooxygenase | 2018 |
Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats.
Topics: Alpinia; Animals; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Female; Gastric Mucosa; Indomethacin | 2018 |
The gastroprotective effect of N-acetylcysteine and genistein in indomethacin-induced gastric injury in rats.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, | 2018 |
Gastroprotective and anti-ulcer effects of oxymatrine against several gastric ulcer models in rats: Possible roles of antioxidant, antiinflammatory, and prosurvival mechanisms.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Apoptosis; Catalase; | 2018 |
Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats.
Topics: Animals; Antioxidants; Gastric Juice; Gastric Mucosa; Indomethacin; Lipid Peroxidation; Male; Naphth | 2018 |
Artepillin C, drupanin, aromadendrin-4'-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action.
Topics: Animals; Anti-Ulcer Agents; Cinnamates; Ethanol; Flavonoids; Hydrochloric Acid; Indomethacin; Kaempf | 2018 |
Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats1.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Asphodelaceae; Dose-Response Relationship, Drug; Glutathio | 2018 |
Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Ag | 2018 |
[MECHANISMS OF PROULCEROGENIC EFFECT OF CORTISOL AT PHARMACOLOGICAL DOSE ON THE GASTRIC MUCOSA].
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Body Weight; Gastric Mucosa; Hydrocortisone; Indom | 2016 |
[TRANSFORMATION OF GASTROPRO- TECTIVE EFFECT OF STRESS IN PROULCEROGENIC CONSEGUENCE: DEVELOPMENT OF EXPERIMENTAL MODELS].
Topics: Adaptation, Physiological; Animals; Cold Temperature; Darkness; Immobilization; Indomethacin; Male; | 2017 |
Chemical composition, antioxidant and gastrointestinal properties of Sedum dendroideum Moc & Sessé ex DC leaves tea infusion.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Caco-2 Cells; Ethanol; Female; Humans; Indomethacin; Mice; | 2019 |
Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats.
Topics: Acetophenones; Animals; Anti-Ulcer Agents; Caspase 3; Gastric Mucosa; Gene Expression Regulation; Gl | 2019 |
Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liv | 2018 |
Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Fluvoxa | 2019 |
Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.
Topics: Animals; Antioxidants; Fermentation; Gastric Mucosa; Hordeum; Indomethacin; Lipid Peroxidation; Male | 2019 |
Vulnerability of gastric and small intestinal mucosa to ulcerogenic action of indomethacin in C57/BL6/J mice and transient receptor potential channel vanilloid type 1 knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Gastric Mucosa; Indomethacin; Intestina | 2018 |
Anti-oxidant and anti-inflamatuar effectiveness of caftaric acid on gastric ulcer induced by indomethacin in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Female; Indomethacin; Oxidants; Phenols; Rats; Rats, Sprag | 2019 |
Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice.
Topics: Animals; Antioxidants; Brazil; Catechin; Chromatography, High Pressure Liquid; Disease Models, Anima | 2019 |
Gastroprotective Effects of Plants Extracts on Gastric Mucosal Injury in Experimental Sprague-Dawley Rats.
Topics: Animals; Gastric Mucosa; Gastritis; Indomethacin; Male; Phytotherapy; Plant Extracts; Plant Leaves; | 2019 |
Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Crocus; Cyclohexenes; Indometha | 2019 |
Evaluation of the antiulcer activity of the aqueous stem bark extract of Balanites aegyptiaca L Delile in Wistar rats.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Balanites; Ethanol; Indomethacin; Ligation; Male; Phytother | 2019 |
Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats.
Topics: Aluminum Hydroxide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygena | 2019 |
Antiulcer activity of Cyperus alternifolius in relation to its UPLC-MS metabolite fingerprint: A mechanistic study.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Chromatography, Liquid; | 2019 |
A bis-resorcinol resveratrol congener prevents indomethacin-induced gastric ulceration by inhibiting TNF-α as well as NF-κB and JNK pathways.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Indomethacin; JNK Mitogen-Activated Protein Kinase | 2019 |
Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats.
Topics: Animals; Aspirin; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Gastric | 2019 |
A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats.
Topics: Animals; Antioxidants; Biomarkers; Biopsy; Cytokines; Disease Models, Animal; Esomeprazole; Immunohi | 2019 |
[Therapeutic effect of total triterpenoids of Chaenomeles speciosa combined with omeprazole on gastric ulcer induced by indomethacin in rats].
Topics: Animals; Cytokines; Gastric Mucosa; Indomethacin; Omeprazole; Phytochemicals; Random Allocation; Rat | 2019 |
Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers.
Topics: Alchemilla; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Disease Models, Animal; | 2019 |
Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats.
Topics: Administration, Oral; Animals; Catalase; Dinoprostone; Drug Synergism; Gastric Mucosa; Glutathione; | 2013 |
Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catechols; Disease Models, Anim | 2013 |
Extraction optimization of carbohydrate compound from Huangqi using orthogonal design.
Topics: Animals; Astragalus Plant; Astragalus propinquus; Catalase; Drugs, Chinese Herbal; Glutathione; Glut | 2013 |
Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats.
Topics: Animals; Catalase; Curcumin; Gastric Mucosa; Indomethacin; Male; Malondialdehyde; Nitric Oxide; Prot | 2013 |
Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice.
Topics: Animals; Cell Extracts; Cytokines; Dinoprostone; Fungal Polysaccharides; Indomethacin; Mice; Mucins; | 2013 |
Gastric antisecretory and antiulcer activity of bovine hemoglobin.
Topics: Animals; Anti-Ulcer Agents; Cattle; Cytoprotection; Disease Models, Animal; Dose-Response Relationsh | 2013 |
Nonsteroidal anti-inflammatory drugs (NSAID) sparing effects of glucosamine hydrochloride through N-glycosylation inhibition; strategy to rescue stomach from NSAID damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Glucosamine; Glycosyl | 2013 |
The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Drug Interactions; Folic Acid; Gastric M | 2012 |
Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model.
Topics: Acetates; Animals; Anti-Ulcer Agents; Cyclopropanes; Disease Models, Animal; Famotidine; Gastric Muc | 2013 |
Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats.
Topics: Animals; Anti-Ulcer Agents; Carbolines; Cimetidine; Dose-Response Relationship, Drug; Gastric Acid; | 2012 |
Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antipyretics; Carrageenan; Dinopro | 2012 |
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Carrageenan; Dinoprostone; Disease Models, Animal; Ed | 2013 |
Effect of menthol in experimentally induced ulcers: pathways of gastroprotection.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channels; Castor Oil; Cyclic GMP; Diarrhea | 2013 |
Does chronic stress enhance the risk of diseases?
Topics: Adrenergic alpha-Antagonists; Angina Pectoris; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chr | 2013 |
Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethanol; Indometha | 2014 |
Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats.
Topics: Alginates; Anemia; Animals; Anti-Ulcer Agents; Atrophy; Bacterial Translocation; Biomarkers; Capilla | 2014 |
The impact of dehydroepiandrosterone on indomethacin-induced gastric lesions in rats.
Topics: Animals; Antioxidants; Catalase; Cytoprotection; Dehydroepiandrosterone; Disease Models, Animal; Gas | 2014 |
Cytoprotective and antioxidant effects of the methanol extract of Eremomastax speciosa in rats.
Topics: Acanthaceae; Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Cold Temperature; Ethanol; Gastric | 2014 |
Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Diterpenes, Clerodane; Enzyme Inhibitor | 2014 |
Intravenous ilaprazole is more potent than oral ilaprazole against gastric lesions in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric A | 2014 |
Gastric antiulcerogenic and hypokinetic activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae).
Topics: Animals; Antioxidants; Combretaceae; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Mice; Nitr | 2014 |
Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Indomethacin; Ma | 2013 |
L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Glutamates; Indomethacin; Lipid Pero | 2014 |
The effect of induction of endogenous CO by heme-oxygenase inducer, hemin versus heme-oxygenase blocker, zinc mesoporphyrin on gastric secretion and ulceration under different conditions in adult male albino rats.
Topics: Animals; Carbon Monoxide; Cold-Shock Response; Cyclooxygenase Inhibitors; Gastric Juice; Gastric Muc | 2014 |
Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Appetite Depressants; Calcium-Bindin | 2015 |
Protective effects of escin against indomethacin-induced gastric ulcer in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Dose-Response Rel | 2014 |
Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice.
Topics: Acetic Acid; Adrenergic alpha-2 Receptor Antagonists; Animals; Anti-Ulcer Agents; Cyclooxygenase Inh | 2014 |
Gastroprotective activity of violacein isolated from Chromobacterium violaceum on indomethacin-induced gastric lesions in rats: investigation of potential mechanisms of action.
Topics: Animals; Apoptosis; Chromobacterium; Female; Indoles; Indomethacin; Male; Prostaglandins; Protective | 2014 |
Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Catalase; Cytokines; Dinoprostone; Drugs, Chinese Herbal; Ethanol; Gastr | 2014 |
Antiulcer activity of the ethanolic extract and ethyl acetate fraction of the leaves of Markhamia tomentosa in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Bignoniaceae; Chromatography, Liquid; Disease Models, Animal; | 2014 |
Rational Design and Synthesis of Benzamides as Non-ulcerogenic Anti-inflammatory Agents.
Topics: Animals; Benzamides; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Carrageenan; Cyclooxy | 2015 |
Antiulcerogenic activity of Carica papaya seed in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carica; Ethanol; F | 2015 |
Gastroprotective effects of goniothalamin against ethanol and indomethacin-induced gastric lesions in rats: Role of prostaglandins, nitric oxide and sulfhydryl compounds.
Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; N | 2014 |
[Somatic pain sensitivity under indometacin induced gastric and small intestinal injury in rats].
Topics: Adrenal Glands; Animals; Body Weight; Corticosterone; Fasting; Gastric Mucosa; Indomethacin; Intesti | 2014 |
Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Catalase; Cucurbitaceae; Dinoprostone; Gastric Juice; Gastric Mucosa; In | 2015 |
A wider view on gastric erosion: detailed evaluation of complex somatic and behavioral changes in rats treated with indomethacin at gastric ulcerogenic dose.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Body Temperature; Brain; Dose-Re | 2014 |
S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibition.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cyclooxyge | 2014 |
Primary characterization and evaluation of anti ulcerogenic activity of an aqueous extract from callus culture of Cereus peruvianus Mill. (Cactaceae).
Topics: Animals; Anti-Ulcer Agents; Cactaceae; Carbohydrates; Ethanol; Indomethacin; Male; Plant Extracts; P | 2015 |
Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.
Topics: Alanine; Animals; Anti-Ulcer Agents; Artemisia; Coumarins; Ethanol; Hydrochloric Acid; Indomethacin; | 2015 |
Helicteres sacarolha A. St.- Hil. et al.: gastroprotective and possible mechanism of actions in experimental animals.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Ethanol; Gastric Juice; Gastric Mucosa; Glyburid | 2015 |
Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats.
Topics: Animals; Anti-Ulcer Agents; Carica; Disease Models, Animal; Dose-Response Relationship, Drug; Duoden | 2015 |
Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata.
Topics: Anacardiaceae; Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Dose-Response Rel | 2016 |
The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carotenoids; Catalase; Comet Assay; | 2016 |
In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice.
Topics: Animals; Anti-Ulcer Agents; Biological Availability; Chalcones; Flavanones; Gastric Mucosa; Glycyrrh | 2015 |
Boswellia carterii liquisolid systems with promoted anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Cellulose; Chemistr | 2015 |
Gastroprotective potential of Buddleja scordioides Kunth Scrophulariaceae infusions; effects into the modulation of antioxidant enzymes and inflammation markers in an in vivo model.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biomarkers; Buddleja; Down-Regulation; Gastric Mucosa; Ind | 2015 |
Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats.
Topics: Animals; Antioxidants; Catalase; Dinoprostone; Diterpenes; Gastric Mucosa; Glutathione; HSP70 Heat-S | 2015 |
[Metyrapone effect on gastroprotective action of corticotropin-releasing factor administered centrally against indomethacin-induced gastric injury].
Topics: Animals; Corticosterone; Corticotropin-Releasing Hormone; Gastric Mucosa; Glucocorticoids; Indometha | 2014 |
N-Acetyl Cysteine Has Both Gastro-Protective and Anti-Inflammatory Effects in Experimental Rat Models: Its Gastro-Protective Effect Is Related to Its In Vivo and In Vitro Antioxidant Properties.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Catalase; Drug Evaluat | 2016 |
Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity.
Topics: Animals; Bignoniaceae; Cell Survival; Cells, Cultured; Chitosan; Disease Models, Animal; Drug Carrie | 2015 |
Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits.
Topics: Acrylic Resins; Animals; Anti-Ulcer Agents; Biological Availability; Boswellia; Carboxymethylcellulo | 2016 |
Gastroprotective potential against indomethacin and safety assessment of the homology of medicine and food formula cuttlebone complex.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Gastric Mucosa; Humans; Indomethacin; Male; Mice; Mice, | 2015 |
Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS.
Topics: Amidines; Animals; Atorvastatin; Benzylamines; Dinoprostone; Drug Synergism; Female; Indomethacin; M | 2015 |
Gastroprotective bio-guiding study of fruits from Mimusops balata.
Topics: Animals; Anti-Ulcer Agents; Ethanol; Female; Free Radical Scavengers; Fruit; Gastric Mucosa; Glutath | 2015 |
The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Gastric Mucosa; Gastrointestinal Agents; Hist | 2016 |
Protective activity of crocin against indomethacin-induced gastric lesions in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotenoi | 2016 |
New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies.
Topics: Animals; Carrageenan; Coumarins; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Di | 2015 |
Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats.
Topics: Animals; Centella; Cyclooxygenase 2; Gastric Mucosa; Humans; Indomethacin; Male; Malondialdehyde; Pl | 2016 |
Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethylmaleimide; Glyb | 2016 |
Gastroprotective and Antioxidant Effects of Lobaria pulmonaria and Its Metabolite Rhizonyl Alcohol on Indomethacin-Induced Gastric Ulcer.
Topics: Alcohols; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationsh | 2015 |
Synthesis, Structure Activity Relationship (SAR), and Biological Activities of Benzylideneacetophenones Derivatives.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Carrageenan; Chalcones; Edema; F | 2015 |
Αlpha-2 Adrenergic and Opioids Receptors Participation in Mice Gastroprotection of Abelmoschus esculentus Lectin.
Topics: Abelmoschus; Animals; Ethanol; Indomethacin; Lectins; Male; Mice; Protective Agents; Receptors, Adre | 2016 |
Antiulcer mechanisms of Vernonia condensata Baker: A medicinal plant used in the treatment of gastritis and gastric ulcer.
Topics: Animals; Anti-Ulcer Agents; Catalase; Ethanol; Female; Gastric Mucosa; Gastritis; Glutathione; H(+)- | 2016 |
Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats.
Topics: Alcohols; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Fluoxetine; Gastric Mucosa; Hist | 2016 |
The renin-angiotensin system and its vasoactive metabolite angiotensin-(1-7) in the mechanism of the healing of preexisting gastric ulcers. The involvement of Mas receptors, nitric oxide, prostaglandins and proinflammatory cytokines.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cytokines; Enzyme | 2016 |
[Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal | 2016 |
Nebivolol prevents indomethacin-induced gastric ulcer in rats.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Dinoprostone; Glutathione; Humans; Indomethacin; Male; | 2016 |
Anti-ulcer mechanisms of polyphenols extract of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae).
Topics: Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, Hig | 2016 |
Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer.
Topics: Animals; Edible Grain; Fagopyrum; Gastric Mucosa; Glycine max; Humans; Indomethacin; Male; Mice; Mic | 2016 |
Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers.
Topics: Amides; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Dinoprostone; Fumarates; Glutathione | 2016 |
Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice.
Topics: Alginates; Animals; Disease Models, Animal; Gastrointestinal Motility; Glucuronic Acid; Hexuronic Ac | 2016 |
Complementarity of in vitro and in vivo models for the evaluation of gastro-protective effects of pharmacological substances.
Topics: Alanine; Animals; Anti-Ulcer Agents; Cimetidine; Dose-Response Relationship, Drug; Gastric Mucosa; I | 2017 |
Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats.
Topics: Acute Disease; Animals; Gastric Fundus; Gastric Mucosa; Glutathione; Hydrogen-Ion Concentration; Ind | 2017 |
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Mod | 2017 |
Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages.
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Cell Line; Chloroquine; Endopl | 2017 |
Isolation, characterization, and in silico, in vitro and in vivo antiulcer studies of isoimperatorin crystallized from Ostericum koreanum.
Topics: Animals; Anti-Ulcer Agents; Apiaceae; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Cell | 2017 |
Gastroprotective activity of the resin from Virola oleifera.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, Thin Layer; Disease Models | 2017 |
N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; A | 2017 |
Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats.
Topics: Angiotensin I; Animals; Anti-Ulcer Agents; Dinoprostone; Gastric Juice; Gastric Mucosa; Indomethacin | 2016 |
Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats.
Topics: Aluminum Hydroxide; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Dose- | 2017 |
Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol.
Topics: Animals; Anti-Ulcer Agents; Bauhinia; Flavonoids; Gastric Mucosa; Indomethacin; Kaempferols; Male; M | 2018 |
Gastroprotective and anti-secretory mechanisms of 2-phenylquinoline, an alkaloid isolated from Galipea longiflora.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Antioxidants; Ethanol; Gastric Acid; Gastric Juice; Gastric M | 2017 |
Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Croton; Croton Oil; Ethanol; Fe | 2017 |
Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats.
Topics: Animals; Eugenol; Gastric Mucosa; Glyburide; Indomethacin; Male; Malondialdehyde; Nitrites; Rats; Ra | 2008 |
Gastroprotective mechanisms of centipedic acid, a natural diterpene from Egletes viscosa LESS.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Asteraceae; Cap | 2008 |
Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models.
Topics: Animals; Anti-Ulcer Agents; Ethanol; Female; Gastric Mucosa; Glutathione; India; Indomethacin; Male; | 2008 |
Beneficial effects of vegetable oils (corn, olive and sunflower oils) and alpha-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats.
Topics: alpha-Tocopherol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Corn Oil; Indometh | 2008 |
Antiulcer activity of water extract of Scoparia dulcis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Indomethacin; Ph | 2008 |
Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, | 2008 |
Gastroprotective and anti-oxidative properties of ascorbic acid on indomethacin-induced gastric injuries in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Gastric Mucosa; Glutathione Peroxidase; Glutathione | 2008 |
The antiinflammatory, gastroprotective and antioxidant activities of Hieracium gymnocephalum extract.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Asteraceae; Dose-Response Relati | 2008 |
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Fre | 2008 |
Gastroprotective effect of nicorandil in indomethacin and alcohol-induced acute ulcers.
Topics: Acute Disease; Animals; Ethanol; Gastric Mucosa; Indomethacin; Male; Nicorandil; Nitric Oxide; Prote | 2009 |
Gastric anti-ulcer activity of leaf fractions obtained of polar extract from Wilbrandia ebracteata in mice.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Biphenyl Compounds; Brazil; Cucurbitaceae; Flavono | 2009 |
Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Ulcer Agents; Asteraceae; Enzyme Inhibitors; Ethanol; Ga | 2009 |
Myristica malabarica heals stomach ulceration by increasing prostaglandin synthesis and angiogenesis.
Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; D | 2008 |
Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antidepressive Agents, Tricycli | 2009 |
Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice.
Topics: Animals; Anti-Ulcer Agents; Antineoplastic Agents; Cyclooxygenase 1; Cyclooxygenase 2; Indomethacin; | 2009 |
The effects of methanol extract of Lobaria pulmonaria, a lichen species, on indometacin-induced gastric mucosal damage, oxidative stress and neutrophil infiltration.
Topics: Animals; Catalase; Dose-Response Relationship, Drug; Gastric Mucosa; Glutathione; Glutathione Peroxi | 2009 |
[Suppression of hypotalamic-pituitary-adrenocortical system as a reason of aggravation of indomethacin-induced gastric ulcerogenic effect by cortisol treatment with pharmacological dose].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Corticosterone; Hydrocortisone; Hypothalamo-Hypoph | 2008 |
Antiulcerogenic action of ethanolic extract of the resin from Virola surinamensis Warb. (Myristicaceae).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catechin; Cimetidine; Cold Temp | 2009 |
Antiulcerogenic activity of Combretum leprosum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Combretum; Ethanol; Gastric Aci | 2009 |
Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arginine; Dinoprostone; Drug In | 2009 |
Anti-ulcer activity of IAC, a novel free-radical scavenger, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxida | 2009 |
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Caspase 3; Dinopr | 2009 |
Effects of amodiaquine hydrochloride and artemisinin on indomethacin-induced lipid peroxidation in rats.
Topics: Amodiaquine; Animals; Artemisinins; Gastric Juice; Indomethacin; Lipid Peroxidation; Rats; Rats, Wis | 2008 |
Regulation of arginase/nitric oxide synthesis axis via cytokine balance contributes to the healing action of malabaricone B against indomethacin-induced gastric ulceration in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arginase; Cytokines; Indomethac | 2009 |
Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents | 2009 |
[Ulcer genesis and endogenous intoxication].
Topics: Animals; Disease Models, Animal; Endotoxemia; Gastric Mucosa; Indomethacin; Lipid Metabolism; Lipids | 2008 |
Biphasic activity of resveratrol on indomethacin-induced gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cyclooxygenase 1; Indomethacin; | 2009 |
Gastrointestinal safety and therapeutic efficacy of parenterally administered phosphatidylcholine-associated indomethacin in rodent model systems.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dinoprostone | 2009 |
The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats.
Topics: Animals; Indomethacin; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2009 |
Chemical characterization of the lipophilic fraction of Livistona decipiens and Livistona chinensis fruit pulps (Palmae) and assessment of their anti-hyperlipidemic and anti-ulcer activities.
Topics: Animals; Anti-Ulcer Agents; Arecaceae; Dietary Fats; Fruit; Hyperlipidemias; Hypolipidemic Agents; I | 2009 |
Rocket "Eruca sativa": a salad herb with potential gastric anti-ulcer activity.
Topics: Animals; Anti-Ulcer Agents; Brassicaceae; Ethanol; Gastric Mucosa; Humans; Indomethacin; Mucus; Plan | 2009 |
A role for HSP70 in protecting against indomethacin-induced gastric lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Cell Line, | 2009 |
Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Dose-Re | 2009 |
Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action.
Topics: Animals; Antioxidants; Cyclohexane Monoterpenes; Disease Models, Animal; Dose-Response Relationship, | 2009 |
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Bethanechol; Dose-Response Relationship, Drug; Ethanol; Hydro | 2009 |
Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Antidepressive Agents; Cyclohexanols; Famotidine; Indomethacin; Male; Ra | 2009 |
Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Enzyme Induction; Gastri | 2009 |
Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dinoprostone; Gastric | 2010 |
Gastroprotective and antioxidant effects of opipramol on indomethacin-induced ulcers in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Antioxidants; Catalase; Gastric Mucosa; Glutathione; Indo | 2009 |
Protective Effect of Origanum majorana L. 'Marjoram' on various models of gastric mucosal injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Drugs, Chine | 2009 |
Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: role of nitric oxide, prostaglandins and sulfydryls.
Topics: Animals; Anti-Ulcer Agents; Benzopyrans; Carbenoxolone; Drug Evaluation, Preclinical; Ethanol; Ethyl | 2010 |
Evaluation of gastric toxicity of indomethacin acid, salt form and complexed forms with hydroxypropyl-beta-cyclodextrin on Wistar rats: histopathologic analysis.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyc | 2009 |
Gastroprotective effect of dalargin in gastropathy due to treatment with nonsteroid antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; DNA; Drug Interactions; Enkeph | 2009 |
Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives.
Topics: Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoqu | 2009 |
Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Central Nervous System Depressa | 2009 |
Antiulcer and anticonvulsant activity of Croton zambesicus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticonvulsants; Antipsychotic | 2009 |
[Effect of dexamethasone on indomethacin-induced gastric erosion formation upon duration of the hormonal action].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Gastric Mucosa; Glucocorticoids; In | 2009 |
Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2009 |
Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Capillary Permeability; Gastric Mucosa; Indomethacin; Male | 2010 |
EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose | 2009 |
Synthesis and biological activities of new substituted thiazoline-quinoline derivatives.
Topics: Acetophenones; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal A | 2009 |
Gastroprotective activity of Trichosanthes cucumerina in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Ethanol; Female; Gastric Juice; Gast | 2010 |
The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage.
Topics: Acetylcholine; Administration, Oral; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflamma | 2010 |
Suppression of hypothalamo-hypophyseal-adrenocortical system function as the cause of aggravation of the ulcerogenic action of indomethacin on the stomach after administration of pharmacological doses of hydrocortisone.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Corticoster | 2010 |
Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.
Topics: Acetylcysteine; Animals; Anti-Ulcer Agents; Antioxidants; Capsaicin; Disease Models, Animal; Diterpe | 2010 |
Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats.
Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogens; | 2010 |
Pathogenic importance of cysteinyl leukotrienes in development of gastric lesions induced by ischemia/reperfusion in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Chromones; Gastric Ac | 2010 |
Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine.
Topics: Animals; Antineoplastic Agents; Arginine; Cyclooxygenase 1; Cyclooxygenase 2; Indomethacin; Male; Mi | 2010 |
Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Blood Glucose; Corticosterone; Female; Gastric Mucosa; | 2010 |
Gastric acid is the key modulator in the pathogenesis of non-steroidal anti-inflammatory drug-induced ulceration in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2010 |
Anti-ulcerogenic effect and HPLC analysis of the caffeoylquinic acid-rich extract from Ligularia stenocephala.
Topics: Animals; Anti-Ulcer Agents; Asteraceae; Bethanechol; Chromatography, High Pressure Liquid; Ethanol; | 2010 |
Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Indomethacin; Magnoliopsida; Phytotherapy; Plant | 2009 |
Probiotic bacteria Escherichia coli strain Nissle 1917 attenuates acute gastric lesions induced by stress.
Topics: Animals; Capsaicin; Cyclooxygenase 2; Disease Models, Animal; Escherichia coli; Gastric Mucosa; Ghre | 2009 |
Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Benzoates; Blood Glu | 2010 |
Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action.
Topics: Acetylcholine; Animals; Aspirin; Atropine; Cholinergic Antagonists; Cimetidine; Ethanol; Flax; Gastr | 2010 |
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Rele | 2010 |
Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2.
Topics: Analysis of Variance; Animals; Gastric Mucosa; Histocytochemistry; Indomethacin; Male; Matrix Metall | 2010 |
Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antisense Elements (Genetics); Apoptosis; Caspase | 2010 |
Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models.
Topics: Achyrocline; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Cytoprotection; Disease Models, Animal; | 2010 |
Influence of cyclodextrin complexation with NSAIDs on NSAID/cold stress-induced gastric ulceration in rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextr | 2010 |
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Drugs, Chinese Herbal; Ethanol; Ga | 2010 |
The role of erythropoietin in the protection of gastric mucosa from indometacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Dose-Response Rel | 2010 |
TLQP-21, a VGF-derived peptide, prevents ethanol-induced gastric lesions: insights into its mode of action.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Immunoenzyme | 2010 |
Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E₂, nitric oxide and redox status in indomethacin-induced gastric ulcer model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Capillary Permeability; Dietary | 2010 |
Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2011 |
Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Synergi | 2012 |
Anti-ulcer and antioxidant activity of GutGard.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Dose-Response Relationship, Drug; Female; Gastric Acid; Ga | 2010 |
Synthesis, characterization and pharmacological evaluation of 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one: a new anti-inflammatory compound with reduced gastric ulceration properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Movement; Cyclooxygenase 2 Inhibitors; Diclofena | 2010 |
Attenuation of stress-induced gastric lesions by lansoprazole, PD-136450 and ranitidine in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Animals; Indoles; Indomethacin; Injec | 2011 |
Gastrin-releasing peptide receptor antagonist or N-acetylcysteine combined with omeprazol protect against mitochondrial complex II inhibition in a rat model of gastritis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bombesin; Drug | 2011 |
Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine.
Topics: Administration, Oral; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Blood Proteins; | 2011 |
Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models.
Topics: Animals; Anti-Ulcer Agents; Chromatography, High Pressure Liquid; Disease Models, Animal; Ethanol; F | 2011 |
Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.
Topics: Animals; Antipsychotic Agents; Capillary Permeability; Dinoprostone; Disease Models, Animal; Dopamin | 2011 |
Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin.
Topics: Analysis of Variance; Animals; Collagenases; Diabetes Mellitus, Experimental; Drug Interactions; Gel | 2011 |
Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair.
Topics: Animals; Colony Count, Microbial; Cyclooxygenase 2; Female; Gastric Acid; Gastric Mucosa; Indomethac | 2011 |
Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Coix; Disease Models, Animal; Humans; Indomethacin; M | 2011 |
Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bromeliaceae; Disease Models, A | 2010 |
Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, | 2010 |
Curative effect of selenium against indomethacin-induced gastric ulcers in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Disease Models, An | 2011 |
Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing.
Topics: Animals; Biflavonoids; Catechin; Cell Adhesion Molecules; Immunoblotting; Indomethacin; Mice; Nitric | 2011 |
Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A | 2011 |
Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Catechin; Disease | 2011 |
Gastroprotective and ulcer-healing mechanisms of ellagic acid in experimental rats.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Cytokines; Dinoprostone; Ellagic Acid; Ethanol; Female; Gas | 2011 |
Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Carrageenan; Cell Line, Tum | 2012 |
Microencapsulation enhances the anti-ulcerogenic properties of Entada africana leaf extract.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Capsules; Chemistry, Pharmaceutical; Cytoprotectio | 2011 |
Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antidepressive Agents, Tricycli | 2011 |
Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models.
Topics: Animals; Anti-Ulcer Agents; Catalase; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Eth | 2011 |
Anti-ulcerogenic effect of aqueous propolis extract and the influence of radiation exposure.
Topics: Animals; Anti-Ulcer Agents; Cytokines; Dinoprostone; Gamma Rays; Gastric Mucosa; Indomethacin; Inter | 2011 |
Incorporation of indomethacin nanoparticles into 3-D ordered macroporous silica for enhanced dissolution and reduced gastric irritancy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Carriers; Drug Com | 2011 |
Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae).
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gas C | 2011 |
Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Ferment | 2010 |
Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae).
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Diterpenes; Ethanol; Gastric Acid; Hydrogen-Ion | 2011 |
Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Enzyme-Linked Immunosorbent Assay; Gast | 2012 |
Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Doxycycline; Enzyme Precurs | 2011 |
Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Experimental; Indomethaci | 2011 |
Further evidence of the antiulcer activity of IAC, a novel free radical scavenger.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Free Ra | 2011 |
Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling.
Topics: Animals; Curcumin; Fibrillar Collagens; Indomethacin; Male; Matrix Metalloproteinase 2; Matrix Metal | 2012 |
The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression.
Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Gastric Mucosa; Gastritis; Indomethacin; Intercellula | 2011 |
ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation.
Topics: Administration, Oral; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Arteries; Blood | 2012 |
Pharmacological and histological effects of Centaurea bruguierana ssp. belangerana on indomethacin-induced peptic ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Centaurea; Indomethacin; Male; Plant Extracts; Rats; Rats, Wistar; Stoma | 2012 |
[Gastric mucosal susceptibility for ulcerogenic effect of indometacin at different time points of streptozotocin-induced diabetes development].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Corticosterone; Diabetes Mellitus, | 2011 |
Comparison of gastric ulcerogenicity of percolated extract of Anacardium occidentale (cashew nut) with indomethacin in rats.
Topics: Anacardium; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug | 2012 |
Anti-inflammatory potential of thienopyridines as possible alternative to NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Line; Cytokines; Dis | 2012 |
Essential oil of Croton zehntneri and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer.
Topics: Administration, Oral; Allylbenzene Derivatives; Animals; Anisoles; Brazil; Croton; Disease Models, A | 2013 |
Molecular mechanism of indomethacin-induced gastropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blotting, Western; Cyclooxygenase 2; E | 2012 |
Gastroprotective potential of frutalin, a D-galactose binding lectin, against ethanol-induced gastric lesions.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biomarkers; Capsaicin; Cimetidine; Ethanol; Galactose; Gal | 2012 |
Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Cimetidine; Cytoprotection | 2011 |
Antiulcer principle from Zingiber montanum.
Topics: Animals; Anti-Ulcer Agents; Chromatography; Cytoprotection; Disease Models, Animal; Dose-Response Re | 2012 |
Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity.
Topics: Animals; Bauhinia; Dose-Response Relationship, Drug; Gastrointestinal Agents; Indomethacin; Male; Me | 2012 |
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experiment | 2012 |
Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb.
Topics: Animals; Anti-Ulcer Agents; Calophyllum; Catalase; Chemical Fractionation; Chromatography, High Pres | 2012 |
Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Cyclooxygenase 2; Disease Models | 2012 |
Protective effect of Chresta martii extract against indomethacin-induced gastric lesions in mice.
Topics: Animals; Anti-Ulcer Agents; Asteraceae; Flowers; Indomethacin; Male; Mice; Plant Extracts; Plant Lea | 2013 |
Curcumin prevents indomethacin-induced gastropathy in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Endothelial Cells; Gastric Mucosa; Indom | 2012 |
Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.
Topics: Animals; Anti-Inflammatory Agents; Bethanechol; Disease Models, Animal; Guanidines; Histamine Agonis | 2012 |
[Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytoprotection; D | 2012 |
Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action.
Topics: Alcohols; Animals; Glutathione Peroxidase; Hydroxyl Radical; Indomethacin; Lipid Peroxidation; Malon | 2013 |
Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation.
Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors | 2012 |
Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice.
Topics: Acrolein; Animals; Anti-Ulcer Agents; Aspirin; Cinnamomum zeylanicum; Disease Models, Animal; Drugs, | 2013 |
Antiulcerogenic effect of Croton urucurana Baillon bark.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Croton; Disease Models, Animal; Ethanol; Female; Gastric Ac | 2012 |
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine | 2012 |
High sensitivity of gastric mucosa to ulcerogenic effect of indomethacin in rats with diabetes.
Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental | 2011 |
Effect of HMG-CoA-reductase inhibitor on DNA synthesis and free radical oxidation in the gastric mucosa under normal conditions and during indometacin-induced ulcerative process in the stomach of albino mice.
Topics: Animals; Autoradiography; DNA Replication; Free Radicals; Gastric Mucosa; Hydroxymethylglutaryl-CoA | 2012 |
Gastroprotection of suaveolol, isolated from Hyptis suaveolens, against ethanol-induced gastric lesions in Wistar rats: role of prostaglandins, nitric oxide and sulfhydryls.
Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Cyclooxygenase Inhibitors; Ethanol; Ethylmaleimide; Hypti | 2012 |
Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationshi | 2012 |
Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capsaicin; Dose-Response | 2012 |
DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) accelerates healing of indomethacin-induced stomach ulceration in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Heterocyclic Compounds, 1-Ring; Immu | 2012 |
Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antioxidants; Benzimidazo | 2012 |
Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonic Acid; Cymenes; Edema; Female; Indo | 2012 |
Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf.
Topics: Animals; Anti-Ulcer Agents; Bauhinia; Chloroform; Chromatography, High Pressure Liquid; Cytoprotecti | 2012 |
Chronic gastric ulceration causes matrix metalloproteinases-9 and -3 augmentation: alleviation by melatonin.
Topics: Animals; Antioxidants; Blotting, Western; Chronic Disease; Extracellular Signal-Regulated MAP Kinase | 2012 |
A study on the protective activity of kefir against gastric ulcer.
Topics: Animals; Cultured Milk Products; Gastric Mucosa; Indomethacin; Male; Mucus; Rats; Rats, Wistar; Stat | 2012 |
Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cytoprotection; Dinoprostone; Disease Models, Anim | 2012 |
Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. St.-Hil. (Lytraceae) in experimental animals.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Brazil; Ethanol; Gastrointestinal Transit; Indomethacin; In | 2012 |
[A comparative analysis of corticosterone, cortisol and dexametasone effects on gastric erosion in rats].
Topics: Animals; Blood Glucose; Corticosterone; Dexamethasone; Disease Models, Animal; Hydrocortisone; Indom | 2012 |
Effects of statins in an indomethacin-induced gastric injury model in rats.
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ind | 2012 |
Homopterocarpin contributes to the restoration of gastric homeostasis by Pterocarpus erinaceus following indomethacin intoxication in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzofurans; Benzopyrans; Cimet | 2013 |
Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dose-Respons | 2002 |
The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats.
Topics: Acetone; Administration, Oral; Animals; Anti-Ulcer Agents; Disease Models, Animal; Fabaceae; Gastric | 2002 |
Aggravation of nonsteroidal antiinflammatory drug gastropathy by glucocorticoid deficiency or blockade of glucocorticoid receptors in rats.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Corticosterone; Drug Syner | 2002 |
Mechanisms by which endogenous glucocorticoid protects against indomethacin-induced gastric injury in rats.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Capillary Permeabili | 2002 |
Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis.
Topics: Animals; Arthritis, Experimental; Capillary Permeability; Celecoxib; Cyclooxygenase 1; Cyclooxygenas | 2002 |
Possible mechanism underlying the effect of Semax on the formation of indomethacin-induced ulcers in rats.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Ulcer Agents; Indomethacin; Male; Peptide Fragments; Rats | 2002 |
Antinociceptive and gastroprotective effects of diterpenes from the flower buds of Egletes viscosa.
Topics: Acetic Acid; Analgesics; Animals; Anti-Ulcer Agents; Asteraceae; Diterpenes; Dose-Response Relations | 2002 |
Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat.
Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Dru | 2002 |
Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Duodenal Ulcer; Enzyme | 2002 |
Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.
Topics: Animals; Aspirin; Carbohydrates; Ethanol; Female; Fructose; Glucose; Honey; Indomethacin; Male; Malt | 2002 |
[Pharmacological studies of shundao granules on gastrointestinal track].
Topics: Analgesics; Animals; Anti-Ulcer Agents; Constipation; Drugs, Chinese Herbal; Female; Gastric Acid; G | 1998 |
Effect of amitriptyline on gastric ulceration.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Aspirin; Col | 2002 |
[Synthesis, preliminary antigastrelcosis activity and the protective effect on acute liver injury of zinc chlorin E4].
Topics: Animals; Anti-Ulcer Agents; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 2001 |
Protective effects of steroid saponins from Paris polyphylla var. yunnanensis on ethanol- or indomethacin-induced gastric mucosal lesions in rats: structural requirement for activity and mode of action.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carbohydrate Sequence; Ethanol; | 2003 |
Protective effects of polygodial on gastric mucosal lesions induced by necrotizing agents in rats and the possible mechanisms of action.
Topics: Animals; Aspirin; Ethanol; Gastric Mucosa; Gastrointestinal Agents; Hydrochloric Acid; Indomethacin; | 2003 |
Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin.
Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Chemistry, Pharmaceutical; Cimetidine; Cyclodextrins; D | 2003 |
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodeno | 2003 |
Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Cell Division; Ce | 2003 |
A new furoxan NO-donor rabeprazole derivative and related compounds.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Drug Design; He | 2003 |
Anti-inflammatory and antiulcerogenic effects of the aqueous extract of Lobaria pulmonaria (L.) Hoffm.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Beverages; Carrageenan; Edema; | 2003 |
[ON THE GASTRO-LESIONAL EFFECT OF INDOMETHACIN].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Indoles; Indomethacin; Peptic Ulcer Perforation; | 1964 |
Differences between gastric antiulcer effects of trapencaine enantiomers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carbamates; Central Nervous Sys | 2003 |
Synthesis and anti-inflammatory activity of alkyl/arylidene-2-aminobenzothiazoles and 1-benzothiazol-2-yl-3-chloro-4-substituted-azetidin-2-ones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azetidines; Carrageenan; Chemical Phenomena; Chemi | 2003 |
Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats.
Topics: Acetic Acid; Animals; Dinoprostone; Disease Models, Animal; Drug Administration Schedule; Fibrosis; | 2003 |
Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Caffeine; Dose-Response Relationship, Drug; Ethano | 2003 |
Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Hydrochloric Acid; Hypo | 2003 |
Effects of Azadirachta indica extract on gastric ulceration and acid secretion in rats.
Topics: Animals; Anti-Ulcer Agents; Azadirachta; Cimetidine; Drug Therapy, Combination; Gastric Acid; Histam | 2004 |
Methimazole prevents stress and chemical induced gastropathy in rats.
Topics: Animals; Antithyroid Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Fema | 2003 |
Expression of urokinase-type plasminogen activator and its receptor in gastric fibroblasts and effects of nonsteroidal antiinflammatory drugs and prostaglandin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens; Cells, Cultured; Dinoprostone; DNA Primers; Dose- | 2003 |
[Deficiency of glucocorticoid production delays the healing of acute gastric mucosal erosion and chronic ulcers in rats].
Topics: Acetic Acid; Adrenalectomy; Animals; Chronic Disease; Corticosterone; Gastric Mucosa; Glucocorticoid | 2003 |
Effect of adrenalectomy on healing of indomethacin-induced gastric erosions in rats.
Topics: Adrenalectomy; Animals; Corticosterone; Gastric Mucosa; Glucocorticoids; Indomethacin; Rats; Rats, S | 2003 |
Parietal cell density during gastric ulcer healing in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Count; Female; Helicobacte | 2004 |
Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bethanechol; Cimetidine; Diseas | 2004 |
New amides and gastroprotective constituents from the fruit of Piper chaba.
Topics: Amides; Animals; Anti-Ulcer Agents; Ethanol; Fruit; Indomethacin; Phytotherapy; Piperaceae; Plant Ex | 2004 |
Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Depressants; Cyclooxygenase | 2004 |
Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; G | 2004 |
Roles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach.
Topics: Administration, Oral; Animals; Body Weight; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyg | 2004 |
Effects of indomethacin and rofecoxib on gastric mucosal damage in normal and Helicobacter pylori-infected mongolian gerbils.
Topics: Administration, Oral; Animals; Dinoprostone; Drug Administration Schedule; Drug Synergism; Gastric A | 2004 |
Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.
Topics: Animals; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinopro | 2004 |
Mg,Al layered double hydroxides with intercalated indomethacin: synthesis, characterization, and pharmacological study.
Topics: Aluminum Hydroxide; Animals; Drug Combinations; Female; Gastric Mucosa; Indomethacin; Magnesium Hydr | 2004 |
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Cysteamine; Duodenal | 2004 |
Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2004 |
[Prophylactic use of angiotensin-converting enzyme inhibitors in indomethacin-induced ulcer and erosion lesions of the stomach].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthriti | 2004 |
Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Cissampelos; Female; Indomethacin; Male; Methanol; Phytotherapy; Plant E | 2003 |
Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Cimetidine; Female; Indomethacin; | 2004 |
Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Therapy, Combination; Edema; Indo | 2004 |
Enhancement in the absorption of water and electrolytes from rat intestine by Hemidesmus indicus R. Br. root (water extract).
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Electrolytes; Female; Gastrointestinal | 2004 |
The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Gastric | 2004 |
Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cattle; Cimetidine; Disease Mod | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Effect of Manilkara hexandra (Roxb.) Dubard against experimentally-induced gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Female; Indomethacin; Ligatio | 2004 |
Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat.
Topics: Animals; Ethanol; Gastric Mucosa; Ghrelin; Indomethacin; Injections, Intraventricular; Injections, S | 2004 |
Antiulcer activity of methanol fraction of Barleria lupulina Lindl. in animal models.
Topics: Acanthaceae; Animals; Anti-Ulcer Agents; Duodenal Ulcer; Ethanol; Female; Gastric Mucosa; Indomethac | 2004 |
Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Chronic Diseas | 2005 |
Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Disease Models, Animal; Gastric Mucosa; | 2005 |
Survivin: a novel target for indomethacin-induced gastric injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Culture Techniques; Cyclooxygenase | 2005 |
Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Evaluation, Preclinical; Edema; | 2005 |
Protective effect of ketoconazole against experimentally induced gastric ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Ethanol; Female; Immunologic Fa | 2003 |
Is gastric ulceration different in normal and malnourished rats?
Topics: Acetic Acid; Animals; Body Weight; Corticosterone; Cytoprotection; Dinoprostone; Ethanol; Female; Ga | 2005 |
Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers.
Topics: Animals; Choline; Glucose; Glycerylphosphorylcholine; Indomethacin; Lactic Acid; Male; Nuclear Magne | 2005 |
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indom | 2005 |
Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Colony Count, Microbial; Cyclooxygenase | 2005 |
Therapeutic effect of D-002 (abexol) on gastric ulcer induced experimentally in rats.
Topics: Acetic Acid; Acute Disease; Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Chronic | 2005 |
Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa.
Topics: Animals; Gastric Mucosa; Glutathione; Helicobacter Infections; Helicobacter pylori; Indomethacin; Li | 2005 |
Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Dose-Response Relat | 2005 |
Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Capillary Permeability; Casearia; Indomethacin | 2005 |
Protective role of heat shock protein 27 in gastric mucosal injury.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; | 2005 |
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; | 2005 |
Preliminary evaluation on anti-inflammatory and analgesic effects of Sideritis syriaca L. herba extracts.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biological Assay; Gastric Mucosa; Indomethacin; Male; | 2005 |
Effect of melatonin on secreted and induced matrix metalloproteinase-9 and -2 activity during prevention of indomethacin-induced gastric ulcer.
Topics: Animals; Enzyme Induction; Indomethacin; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase | 2005 |
Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.
Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; | 2005 |
Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats.
Topics: Animals; Antioxidants; Benzofurans; Cytoprotection; Gastric Mucosa; Glutathione Peroxidase; Indometh | 2006 |
Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Dose-Response Relationship, Drug; Glutathione Tr | 2005 |
Importance of the pineal gland, endogenous prostaglandins and sensory nerves in the gastroprotective actions of central and peripheral melatonin against stress-induced damage.
Topics: Administration, Topical; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Ventricles; C | 2005 |
Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer model in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fats, Unsaturated; D | 2005 |
Modulation of gastric hemorrhage and ulceration by oxidative stress and histamine release in Salmonella typhimurium-infected rats.
Topics: Allopurinol; Animals; Antioxidants; Dimethyl Sulfoxide; Disease Models, Animal; Gastric Juice; Gastr | 2005 |
Agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma): a new compound with potent gastroprotective and ulcer healing properties.
Topics: Animals; Anti-Ulcer Agents; Blood Flow Velocity; Blotting, Western; Dinoprostone; Dose-Response Rela | 2005 |
Cell proliferation in the gastric epithelium of the ulcer rat.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Epithelial Cells; | 2005 |
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.
Topics: Amides; Analgesics; Animals; Anti-Inflammatory Agents; Drug Evaluation, Preclinical; Female; Indomet | 2006 |
Bioactive saponins and glycosides. XXIII. Triterpene saponins with gastroprotective effect from the seeds of Camellia sinensis--theasaponins E3, E4, E5, E6, and E7.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Camellia; Carbohydrate Sequence | 2005 |
Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Electron Spin Resonance Spectroscopy; Indomethacin | 2006 |
Nonsteroidal antiinflammatory agents-part 2 antiinflammatory, analgesic and antipyretic activity of some substituted 3-pyrazolin-5-ones and 1,2,4,5,6,7-3H-hexahydroindazol-3-ones.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ed | 2006 |
Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed.
Topics: Animals; Catalase; Flavonoids; Garcinia kola; Gastric Mucosa; Glutathione; Hydrochloric Acid; Incide | 2006 |
Acetazolamide interferes with the protective effect of prostaglandin E2 in the rat gastric mucosa.
Topics: Acetazolamide; Alkalies; Animals; Carbonic Anhydrase Inhibitors; Cyclooxygenase Inhibitors; Dinopros | 1981 |
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In | 2006 |
Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?
Topics: Analysis of Variance; Animals; Collagen; Granulation Tissue; Hydroxyproline; Immunohistochemistry; I | 2006 |
Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats.
Topics: Acetic Acid; Adrenal Glands; Animals; Anti-Inflammatory Agents, Non-Steroidal; Consciousness; Cortic | 2006 |
Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, | 2006 |
Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen.
Topics: Acids; Animals; Biomarkers; Curcumin; Electron Spin Resonance Spectroscopy; Enzyme Activation; Gastr | 2006 |
Gastroprotective effect of a traditional Chinese herbal drug "Baishouwu" on experimental gastric lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Apocynaceae; China; Cynanchum; Drugs, Chinese Herbal; Ethanol; Ethnobota | 2006 |
Chronic paroxysmal hemicrania, hemicrania continua and SUNCT: the fate of the three first described cases.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Headache; Humans; Indomethacin; | 2006 |
[Angiotensin II AT1 receptor antagonists as antiinflammatory and gastric protection drugs].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Benzimidazoles; Biphenyl | 2006 |
The inhibition of gastric mucosal lesion, oxidative stress and neutrophil-infiltration in rats by the lichen constituent diffractaic acid.
Topics: Animals; Anisoles; Antioxidants; Gastric Mucosa; Glutathione; Hydroxybenzoates; Indomethacin; Lipid | 2006 |
Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants.
Topics: Animals; Antioxidants; Collagenases; Disease Models, Animal; DNA Primers; Enzyme Precursors; Gene Ex | 2006 |
Mechanisms involved in the gastro-protective effect of STW 5 (Iberogast) and its components against ulcers and rebound acidity.
Topics: Animals; Gastric Acidity Determination; Gastric Juice; Gastrins; Indomethacin; Male; Phytotherapy; P | 2006 |
Prostaglandins, capsaicin-sensitive sensory nerves and neutrophil infiltration, but not nitric oxide, contribute to cold restraint stress-induced gastric adaptation in rats.
Topics: Acclimatization; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cold Temperature; Dinoprostone | 2006 |
Sustained-release tablets of indomethacin-loaded microcapsules: preparation, in vitro and in vivo characterization.
Topics: Animals; Anti-Inflammatory Agents; Area Under Curve; Biological Availability; Calorimetry, Different | 2007 |
Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Duodenoscopy; Duodenum; Gastrointestinal Mot | 2006 |
Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation.
Topics: Acrylic Resins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Carr | 2006 |
Effect of Brazilian green propolis on experimental gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Brazil; Complex Mixtures; Disease Models, Animal; Dose-Response Relation | 2007 |
Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats.
Topics: Adrenergic Agents; Amphetamine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male | 2006 |
Antisecretory and antiulcer activity of Asparagus racemosus Willd. against indomethacin plus phyloric ligation-induced gastric ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Asparagus Plant; Dose-Response | 2006 |
Gastric microcirculation as target of gastroprotective action of glucocorticoid hormones in rats with desensitization of capsaicin-sensitive sensory neurons.
Topics: Adrenalectomy; Animals; Capsaicin; Gastric Mucosa; Glucocorticoids; Indomethacin; Male; Microcircula | 2006 |
[Experimental study of the impact of a single use of indometacine on the morphological structure of the mucous coat of the stomach and small intestine].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enteritis; Gastric Mucosa; Indomethacin; Intestina | 2006 |
Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Anti-Ulcer Agents; Arachidonic Acids; Calcitonin | 2007 |
[Compensatory gastroprotective action of glucocorticoid hormones in the rats with ablation of capsaicin-sensitive neurons].
Topics: Adrenalectomy; Animals; Capsaicin; Corticosterone; Gastric Mucosa; Indomethacin; Male; Neurons; Rats | 2006 |
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani | 2007 |
Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.
Topics: Adrenalectomy; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; alpha- | 2007 |
Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Mucosa; Indomethac | 2007 |
The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments.
Topics: Analgesics; Animals; Indomethacin; Iran; Male; Medicine, Traditional; Mice; Phytotherapy; Plant Extr | 2007 |
Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Centra | 2007 |
Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats.
Topics: Acetic Acid; Alendronate; Animals; Bone Density Conservation Agents; Cells, Cultured; Cyclooxygenase | 2007 |
Evaluation of the anti-ulcerogenic effect of sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis by using various in vivo and biochemical techniques.
Topics: Animals; Anti-Ulcer Agents; Behavior, Animal; Centaurea; Dose-Response Relationship, Drug; Enzyme In | 2007 |
The effect of nonsteroidal anti-inflammatory drugs on rat gastric mucosa. The role of endothelin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bosentan; Endothelin Receptor Antagonists; Endothe | 2007 |
Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Bezafibrate; Ethanol; Gastric Acid; Gastric Mucosa; Indomet | 2007 |
Effect of (S)-4-(1-(5-chloro-2-(4-fluorophenyoxy)benzamido)ethyl) benzoic acid (CJ-42794), a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa.
Topics: Animals; Benzamides; Benzoates; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lactones; Peptic Ul | 2007 |
Influence of DL-alpha-tocopherol acetate on indomethacin-induced gastric mucosal injury in rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Gastric Mucosa; Glutathione; Glutathione Disulfide; Indomet | 2007 |
Gastric antisecretory and antiulcer effects of simvastatin in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Ethanol; Female; Gastric Acid; Gastric Mucosa; Indomethaci | 2007 |
Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng.
Topics: Animals; Dammaranes; Disease Models, Animal; Ethanol; Flowers; Gastrointestinal Agents; Glycosides; | 2007 |
Antinociceptive and anti-inflammatory steroidal saponins from Dracaena ombet.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose- | 2007 |
Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Brazil; Cimetidine; Disease Mod | 2007 |
Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Catechols; Disease Models, Animal; DNA; Gastric | 2007 |
Cytoprotective effects of Bergenia ciliata Sternb, extract on gastric ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cytoprotection; Ethanol; Hydroc | 2007 |
Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnitine; Chemoprevention; | 2006 |
Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+,K+ -ATPase activity and formation of nitric oxide.
Topics: Acetic Acid; Animals; Female; Flavonoids; Gastric Acid; Gastric Juice; Gastric Mucosa; Glutathione; | 2007 |
Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Biotransfo | 2007 |
Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Animals; Anti-Ulcer Agents; Antioxidants; Catalas | 2007 |
Gastroprotective activity of the hydroalcoholic extract obtained from Polygala paniculata L. in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Brazil; Colorimetry; Dose-Response Relationship, Drug; Eth | 2007 |
Modulation of indomethacin-induced gastric injury by spermine and taurine in rats.
Topics: Animals; Gastric Mucosa; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Indomethacin; M | 2007 |
Gastroprotective effect of mangiferin, a xanthonoid from Mangifera indica, against gastric injury induced by ethanol and indomethacin in rodents.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Hydrogen-Ion Co | 2007 |
Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; | 2007 |
Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels.
Topics: Animals; Arginine; Capsaicin; Diazoxide; Dose-Response Relationship, Drug; Ethanol; Glyburide; Indom | 2008 |
Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease | 2008 |
The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease M | 2007 |
Anti-ulcer, anti-inflammatory and antioxidant activities of the n-butanol fraction from Pteleopsis suberosa stem bark.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Combretaceae; Dose-Response Rela | 2008 |
Effects of progesterone on FSH-stimulated indomethacin ulcers in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogens; Female; Follicle Stimu | 2008 |
Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell P | 2008 |
Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats.
Topics: Amiodarone; Animals; Antioxidants; Gastric Mucosa; Glutathione; Glutathione Transferase; Indomethaci | 2007 |
Anti-ulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice.
Topics: Analgesia; Analgesics; Animals; Bethanechol; Crassulaceae; Flavonoids; Gastric Juice; Hydrochloric A | 2007 |
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An | 2007 |
Annexin-1 modulates repair of gastric mucosal injury.
Topics: Animals; Annexin A1; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dexamethasone; Dose | 2008 |
Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Dinoprostone; Dose-Response Relationship, Drug; Ep | 2008 |
Gastroprotective effect of a flavone from Lonchocarpus araripensis Benth. (Leguminosae) and the possible mechanism.
Topics: Animals; Anti-Ulcer Agents; Derris; Dose-Response Relationship, Drug; Ethanol; Flavones; Gastric Muc | 2008 |
Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aortic Diseases; Fatal Outcome; Fundoplication; Gastric Fis | 2008 |
The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Boswellia; Ethanol; Hot Temperature; Hydrochloric Acid; Indomet | 2008 |
Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catechols; Cyclooxygenase 1; Cyclooxygenase 2; Dinoproston | 2008 |
Life-threatening illness in those with severe mental handicap.
Topics: Female; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Peptic Ulcer Perforation; | 1981 |
The effect of stress and indomethacin, carbenoxolone, salbutamol, metiamide, zolimidine and CF19415 on rat gastric mucus.
Topics: Acetonitriles; Albuterol; Animals; Anti-Ulcer Agents; Carbenoxolone; Gastric Mucosa; Indomethacin; M | 1981 |
Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Butanones; F | 1982 |
The effect of levamisole on gastric ulcers induced in the rat by anti-inflammatory and necrotizing agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Ethanol; Hydrochloric Acid; Indomethacin; Leva | 1984 |
Do prostaglandins mediate the somatostatin preventive effect on gastric lesion?
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Male; Prostaglandins; Rats | 1984 |
[Effect of prostaglandin E1 on gastric mucin secretin and acute mucosal lesions in rat (author's transl)].
Topics: Acute Disease; Animals; Cold Temperature; Gastric Mucins; Gastric Mucosa; Indomethacin; Male; Prosta | 1980 |
Ulceration induced by an endoperoxide analog and by indomethacin in the canine stomach.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Dogs; Gastric Mucosa; I | 1983 |
Gastric mucosal prostaglandin generation in rats with stress ulcer.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cold Temperature; Gastric Mucosa; Humans; Indomethacin; Male; | 1983 |
The relationships between indomethacine-induced gastric ulcer, ulcer protection by cimetidine and prostacyclin and the cAMP system of the gastric fundic mucosa in the rat.
Topics: Animals; Cimetidine; Cyclic AMP; Epoprostenol; Female; Gastric Fundus; Gastric Mucosa; Guanidines; I | 1982 |
Inhibition of PG production by MDL 035, a new non-steroidal non-acidic anti-inflammatory compound, in rat gastric mucosa and inflammatory exudate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoproston | 1984 |
Gastric antral ulcers produced by the combined administration of indomethacin with 2-deoxy-D-glucose in the rat.
Topics: Animals; Deoxy Sugars; Deoxyglucose; Drug Interactions; Gastric Acid; Indomethacin; Insulin; Male; P | 1983 |
Cytoprotection and 6-keto-prostaglandin-F1 alpha.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dose-Response Relationship, Drug; Epoprostenol; Female; Gastr | 1983 |
Prevention of gastric mucosal lesions in rats by tri-potassium di-citrato bismuthate.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Epoprostenol; Ethanol; Gastric Mucosa; Indomethacin; Male; Orga | 1984 |
Stimulation of gastric prostaglandin synthesis by refeeding in the rat. Role in protection of gastric mucosa from damage.
Topics: Animals; Aspirin; Dinoprost; Eating; Epoprostenol; Evaluation Studies as Topic; Female; Gastric Muco | 1984 |
Prostacyclin and DNA-synthesis inhibitors: their interaction on experimental gastric ulcer in the rat.
Topics: Animals; Cytarabine; DNA; Epoprostenol; Female; Indomethacin; Rats; Rats, Inbred Strains; Stomach Ul | 1984 |
Prostaglandin content in the rat gastric mucosa during healing of chronic ulcers induced by acetic acid.
Topics: Acetates; Animals; Carbonic Anhydrases; Gastric Mucosa; Indomethacin; Male; Prostaglandins; Rats; Ra | 1983 |
Enhancement by intracerebroventricular thyrotropin-releasing hormone of indomethacin-induced gastric lesions in the rat.
Topics: Animals; Drug Interactions; Gastric Acid; Gastric Juice; Gastric Mucosa; Indomethacin; Injections, I | 1983 |
M&B 28,767: a potent anti-secretory and anti-ulcer PG analogue. A comparative study with 16, 16' dimethyl PGE2 methylester.
Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Constipation; Diarrhea; Gastric Acid; Gastroin | 1984 |
[Nitrogenous triterpene derivatives. 9. 3-Acetyloleanol acid-28-amides and their antiulcer effect].
Topics: Animals; Anti-Ulcer Agents; Chemical Phenomena; Chemistry; Indomethacin; Male; Rats; Stomach Ulcer; | 1984 |
Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat.
Topics: Animals; Drug Combinations; Ethanol; Female; Gastric Mucosa; Indomethacin; Intestinal Diseases; Inte | 1984 |
Evidence for the existence of gastric cytoprotective effect of atropine and cimetidine in humans.
Topics: Adult; Atropine; Cimetidine; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastric Mucosa; | 1984 |
Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals.
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Female; Gastric Acid; Gastric Mucosa; | 1984 |
Effects of exogenous administration of female sex hormones on gastric secretion and ulcer formation in the rat.
Topics: Animals; Aspirin; Estrogens; Gastric Juice; Gonadal Steroid Hormones; Humans; Indomethacin; Male; Pr | 1984 |
Water-immersion stress induces mucosal ischemia due to thromboxane A2-like substance and ulcer formation in rats.
Topics: Animals; Gastric Acid; Gastric Mucosa; Humans; Imidazoles; Immersion; Indomethacin; Ischemia; Male; | 1984 |
MDL-646, a new synthetic E1-prostaglandin with local protective effects on the gastric mucosa.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Blood Pressure; Ethanol; Gastric Juice; Gastric Mucosa; Hea | 1984 |
Gastric cytoprotective properties of SCH 32651, a novel antiulcer agent.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cysteamine; Drug Evaluation, Preclinical; Duoden | 1984 |
Protective action of almagate against bile-facilitated gastric ulceration in the pylorus-ligated (Shay) rat.
Topics: Aluminum Hydroxide; Animals; Antacids; Bile; Carbonates; Female; Indomethacin; Magnesium; Magnesium | 1984 |
Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC).
Topics: Adult; Anti-Inflammatory Agents; Aspirin; Carbazoles; Duodenal Ulcer; Gastric Mucosa; Humans; Indome | 1984 |
Cytoprotective effect of SU-88, an anti-ulcer agent, in the rat.
Topics: Animals; Anti-Ulcer Agents; Cell Survival; Chalcone; Chalcones; Cimetidine; Dinoprostone; Ethanol; G | 1984 |
Cytoprotective and antisecretory effects of 11-deoxy-13,14-didehydro-16(s)-methyl PGE2 methylester (FCE 20700).
Topics: Animals; Anti-Ulcer Agents; Diarrhea; Dinoprostone; Ethanol; Gastric Juice; Indomethacin; Intestines | 1984 |
Further evidences on gastric cytoprotection exerted by pirenzepine.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; | 1984 |
Effects of sofalcone on necrotizing agents-induced gastric lesions and on endogenous prostaglandins in rats stomachs.
Topics: Animals; Anti-Ulcer Agents; Chalcone; Chalcones; Dinoprostone; Gastric Mucosa; Indomethacin; Male; N | 1984 |
Functional cytoprotection by certain antacids.
Topics: Animals; Antacids; Aspirin; Dinoprostone; Ethanol; Gastric Acidity Determination; Gastric Mucosa; In | 1984 |
Pharmacological properties of the antiinflammatory agent 10-methylamine-11-H-indeno-[1,2-b]quinolin-11-one (MB432).
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Indomet | 1983 |
Research on heterocyclic compounds. XV. Substitution influence on the pharmacological activity in a series of imidazo[1,2-a]pyridines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Imidazoles; Indomethacin; Lysosomes; | 1983 |
Research on heterocyclic compounds. XVII. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic A | 1984 |
A method for induction of cold, indomethacin and restraint ulcers in rats.
Topics: Animals; Antacids; Atropine; Cimetidine; Cold Temperature; Dose-Response Relationship, Drug; Indomet | 1983 |
[Effect of 11-deoxyprostaglandin E1 on secretion of gastric juice].
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Ethanol; Gastric Acid; Gastric Juice; Indomethacin; Male; P | 1983 |
Rapid induction of gastric ulceration in guinea pigs by sequential exposure to a barrier breaker and indomethacin.
Topics: Animals; Bile; Gastric Mucosa; Guinea Pigs; Indomethacin; Lysophosphatidylcholines; Stomach Ulcer; T | 1983 |
Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dogs; Edema; Female; Guinea Pigs; Hemodynamics; Hind | 1983 |
Different protective effects of dimercapto-butanediol stereoisomers in experimental gastric ulceration.
Topics: Animals; Dithioerythritol; Dithiothreitol; Female; Indomethacin; Rats; Rats, Inbred Strains; Stereoi | 1983 |
[Hyperbaric oxygen therapy in indomethacin-induced gastric ulcer].
Topics: Animals; Hyperbaric Oxygenation; Indomethacin; Male; Rats; Stomach Ulcer | 1983 |
Effect of prostaglandin synthesis inhibitors on neurotensin and sodium salicylate-induced gastric cytoprotection in rats.
Topics: Animals; Aspirin; Cold Temperature; Ethanol; Humans; Indomethacin; Male; Neurotensin; Prostaglandin | 1983 |
Anti-ulcer activity and other pharmacological properties of lozilurea.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Dogs; Duodenal Ulcer; Female; Gastric Mucosa; Guinea Pigs; Hexo | 1983 |
Effects of an antiulcer drug, sucralfate (a basic aluminum salt of sulfated disaccharide), on experimental gastric lesions and gastric secretion in rats.
Topics: Acetates; Aluminum; Animals; Anti-Ulcer Agents; Aspirin; Gastric Mucosa; Histamine; Indomethacin; Ra | 1983 |
FCE 20700, a cytoprotective PGE2 derivative, does not interfere with the antiinflammatory activity of indomethacin.
Topics: Animals; Dinoprostone; Drug Interactions; Gastric Mucosa; Indomethacin; Male; Prostaglandins E, Synt | 1983 |
Indomethacin decreases resistance of gastric barrier to disruption by alcohol.
Topics: Administration, Topical; Animals; Dogs; Ethanol; Female; Gastric Mucosa; Hydrogen-Ion Concentration; | 1984 |
Role of lymphoid nodules in pathogenesis of indomethacin-induced gastric lesions in dogs.
Topics: Administration, Oral; Animals; Dogs; Gastric Mucosa; Indomethacin; Lymphatic System; Male; Pyloric A | 1984 |
Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats.
Topics: Animals; Aspirin; Benzimidazoles; Chemical Phenomena; Chemistry; Duodenal Ulcer; Epirizole; Gastric | 1984 |
Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Synergism; Female; Indomet | 1984 |
Ulcerogenic effects of indomethacin in pregnant rats.
Topics: Animals; Female; Indomethacin; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Stomach Ulc | 1984 |
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Biotransformation; Fenoprofen; Ibuprofen; Indometha | 1980 |
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Indomethacin; Intestinal Diseases; Male; | 1981 |
Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Diflunisal; Indomethaci | 1981 |
Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics.
Topics: Animals; Anti-Bacterial Agents; Bacitracin; Ethanol; Female; Gastric Juice; Germ-Free Life; Indometh | 1983 |
Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Carrageenan; Clonidine; Drug Therapy, | 1983 |
Role of surface-active phospholipids in gastric cytoprotection.
Topics: Animals; Gastric Mucosa; Indomethacin; Phospholipids; Prostaglandins; Rats; Stomach Ulcer; Surface-A | 1983 |
Gastric antisecretory and cytoprotective activities of SCH 28080.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dogs; Ethanol; Female; Gastric Acid; Gastric Mucosa | 1983 |
[Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats].
Topics: Animals; Aspirin; Depression, Chemical; Duodenal Ulcer; Ethanol; Gastric Juice; Immersion; Indometha | 1983 |
Exacerbation of acetic acid ulcer induced by non-steroidal anti-inflammatory drugs in rats.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents; Aspirin; Gastric Emptying; Gastric Juice; | 1983 |
Role of gastric acid and prostaglandins in the formation of gastric antral ulcers produced by indomethacin in the rat.
Topics: Animals; Cimetidine; Dinoprostone; Gastric Juice; Guanidines; Indomethacin; Prostaglandins E; Rats; | 1981 |
Role of prostaglandin E2 on gastric ulcers induced by non-steroidal anti-inflammatory compounds (NOSAC).
Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Prostaglandins E; Rats; Rats, In | 1981 |
[The role of endogenous prostaglandin in drug-induced gastrointestinal lesions--comparison of aspirin and indomethacin (author's transl)].
Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Intestinal Diseases; Intestinal Mucosa | 1981 |
[On the pharmacodynamics of acemetacin (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cats; Central Nervous Sy | 1980 |
[Non-steroidal antirheumatics: side-effects and interactions].
Topics: Anemia, Aplastic; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Drug Interactions; Gastrointes | 1982 |
Indomethacin decreases arterial blood pressure and plasma renin activity in rats with aortic ligation.
Topics: Animals; Aorta; Blood Pressure; Heart Rate; Hypertension; Indomethacin; Ligation; Male; Rats; Renin; | 1981 |
Cytoprotection by sulglycotide: prevention of gastric necrosis in rat.
Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Epoprostenol; Gastric Mucosa; Indomethacin; Male; Necrosi | 1981 |
Effects of a novel acylindole derivative on experimental thrombotic models, ulceration of the gastric mucosa and prostacyclin production in the aorta.
Topics: Animals; Aorta; Arteriovenous Shunt, Surgical; Blood Platelets; Epoprostenol; Fibrinolytic Agents; G | 1981 |
Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins.
Topics: Acetaminophen; Animals; Aspirin; Epoprostenol; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; | 1982 |
[Antiulcerogenic action of 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one (KB-509), a new benzodiazepine derivative].
Topics: 11-Hydroxycorticosteroids; Animals; Anticonvulsants; Benzodiazepinones; Drug Evaluation, Preclinical | 1981 |
The influence of paracetamol on the erosive activity of indomethacin in the rat stomach.
Topics: Acetaminophen; Administration, Oral; Animals; Aspirin; Indomethacin; Injections, Subcutaneous; Male; | 1982 |
[Pyopneumopericarditis complicating a perforated hiatus hernia ulcer (author's transl)].
Topics: Aged; Female; Hernia, Diaphragmatic; Hernia, Hiatal; Humans; Indomethacin; Peptic Ulcer Perforation; | 1982 |
Testing for drugs inhibiting the formation of gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cold Temperature; Copper; Indomethacin; Mucus; Orga | 1982 |
Gastroprotective and anti-inflammatory properties of green lipped mussel (Perna canaliculus) preparation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bivalvia; Female; Freeze Drying; Indomethacin; Male; Rat | 1980 |
Effects of CL-1700 and its constituents on acute or chronic gastric lesions and gastric secretion in rats.
Topics: Aluminum Hydroxide; Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dipeptides; Gastric Juice; Hista | 1982 |
Does indomethacin activate healed gastric ulcers in the dog?
Topics: Animals; Dogs; Indomethacin; Male; Stomach Ulcer | 1981 |
Indomethacin produces gastric antral ulcers in the refed rat.
Topics: Adrenalectomy; Animals; Aspirin; Fasting; Indomethacin; Intestines; Male; Phenylbutazone; Prostaglan | 1981 |
Interaction of indomethacin and aspirin or mepirizole in rats as shown by gastrointestinal ulcerogenic and anti-inflammatory activities.
Topics: Animals; Aspirin; Biological Transport; Charcoal; Drug Interactions; Edema; Epirizole; Indomethacin; | 1980 |
Synthesis and anti-ulcer activity of 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1.
Topics: Alprostadil; Animals; Indomethacin; Magnetic Resonance Spectroscopy; Prostaglandins E, Synthetic; Ra | 1981 |
[Inhibition of indomethacin-induced gastric ulceration in the rat by 7-oxo-prostaglandin E1 analogs (author's transl)].
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Prost | 1981 |
Gastric cytoprotection by sodium salicylate.
Topics: Animals; Aspirin; Ethanol; Gastric Mucosa; Indomethacin; Male; Rats; Salicylates; Salicylic Acid; St | 1981 |
Study of antiulcer activity of aqueous extract of leaves of Pyrenacantha staudtii (family Icacinaceae) using various models of experimental gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Female; Indomethacin; Male; Nigeria; Pl | 1981 |
Aggravating effect of ergometrine on pyloric antral lesions in indomethacin-treated animals and stimulating effect of this drug on gastric acid secretion.
Topics: Animals; Ergonovine; Gastric Acid; Indomethacin; Male; Methysergide; Mice; Mice, Inbred Strains; Pyl | 1981 |
Effects of N-acetyl-L-carnosine aluminum (CL-1700) on various acute gastric lesions and gastric secretion in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dipeptides; Gastric Mucosa; Indomethacin; Male; Phen | 1981 |
The effects of indomethacin of the rat gastric mucosa.
Topics: Animals; Gastric Mucosa; Indomethacin; Rats; Rats, Inbred Strains; Stomach Ulcer; Time Factors | 1981 |
Gastric perforation associated with indomethacin therapy in a pre-term infant.
Topics: Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant, | 1980 |
Gastrointestinal myoelectric activity disturbances in gastric ulcer disease in rats and dogs.
Topics: Animals; Digestive System; Dogs; Duodenum; Electrophysiology; Female; Gastrointestinal Motility; Ind | 1980 |
Indomethacin and perforated duodenal ulcer.
Topics: Duodenal Ulcer; Humans; Indomethacin; Peptic Ulcer Perforation; Stomach Ulcer | 1980 |
Indomethacin and perforated duodenal ulcer.
Topics: Duodenal Ulcer; Female; Humans; Indomethacin; Middle Aged; Peptic Ulcer Perforation; Stomach Ulcer | 1980 |
Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal.
Topics: Animals; Diflunisal; Drug Therapy, Combination; Granuloma; Indomethacin; Male; Rats; Salicylates; St | 1980 |
[Cytoprotection. A new fashion or real progress?].
Topics: Animals; Aspirin; Gastric Mucosa; Gastritis; Humans; Indomethacin; Prostaglandins E, Synthetic; Rats | 1980 |
[Reduced ulcerogenic effect after treatment with indomethacin combined with diflunisal in rats].
Topics: Animals; Diflunisal; Drug Interactions; Gastric Mucosa; Indomethacin; Male; Potassium Permanganate; | 1980 |
Different effects of indomethacin and nabumetone on prostaglandin-mediated gastric responses to central vagal activation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Gastric Juice; Indomethacin; Male; Nabu | 1995 |
Sulpiride specifically attenuates psychological stress-induced gastric lesions in rodents.
Topics: Animals; Anti-Ulcer Agents; Famotidine; Gastric Acid; Indomethacin; Male; Mice; Mice, Inbred ICR; Py | 1995 |
Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats.
Topics: Animals; Cyclosporine; Duodenal Ulcer; Immunosuppressive Agents; Indomethacin; Intestine, Small; Mal | 1994 |
Omentum and basic fibroblast growth factor in healing of chronic gastric ulcerations in rats.
Topics: Animals; Blood Flow Velocity; Chronic Disease; Dinoprostone; Eflornithine; Fibroblast Growth Factor | 1994 |
Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats.
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucins; Hydralazine; Indomethacin; M | 1994 |
Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin.
Topics: Animals; Bromodeoxyuridine; Drug Combinations; Female; Fibroblast Growth Factor 2; Gastric Acid; Gas | 1995 |
The differential mechanisms of mild irritants on adaptive cytoprotection.
Topics: Adaptation, Physiological; Animals; Arginine; Atropine; Capsaicin; Chorionic Gonadotropin; Ethanol; | 1994 |
Effects of free radical scavengers on indomethacin-induced aggravation of gastric ulcer in rats.
Topics: Acetates; Acetic Acid; Allopurinol; Animals; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Free Rad | 1995 |
Ulcerogenicity and effect on inhibition of prostaglandin generation of indometacin farnesil, a prodrug of indomethacin, in rat gastric mucosa: comparison with indomethacin or loxoprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Epoprostenol; Gastric Mucosa; Indome | 1995 |
Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions.
Topics: Acetates; Acetic Acid; Animals; Base Sequence; Cell Line; Cells, Cultured; DNA; Fibroblast Growth Fa | 1995 |
Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1995 |
Gastroprotective activity of the novel proton pump inhibitor lansoprazole in the rat.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Dru | 1995 |
Anti-ulcer effect of the hot water extract of black tea (Camellia sinensis).
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; India; Indomethacin; Plant Extracts; Pros | 1995 |
Antiulcer activity of Pteleopsis suberosa.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Indomethacin; Male; Medicine, Tradition | 1995 |
Effects of lansoprazole on ethanol-induced injury and PG synthetic activity in rat gastric mucosa.
Topics: 16,16-Dimethylprostaglandin E2; 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory | 1995 |
Protection by almagate of ethanol-induced gastric mucosal damage in rats.
Topics: Administration, Oral; Aluminum Hydroxide; Animals; Antacids; Carbonates; Disease Models, Animal; Dos | 1995 |
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Aci | 1995 |
Cytoprotective and antisecretory activity of a ranitidine-zinc complex.
Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Ethanol; Gastric Acid; Gastric Mucosa; | 1995 |
Interaction of nitric oxide and salivary gland epidermal growth factor in the modulation of rat gastric mucosal integrity.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Epidermal Growth Factor; Gastric Muco | 1993 |
Effect of acetaminophen on stress-induced gastric mucosal lesions in rats.
Topics: Acetaminophen; Animals; Dinoprostone; Drug Combinations; Gastric Mucosa; Glutathione; Indomethacin; | 1994 |
The cytoprotective effect of the immunomodulator AS101 against hydrochloride induced gastric lesions.
Topics: Adjuvants, Immunologic; Animals; Dinoprostone; Dose-Response Relationship, Drug; Epidermal Growth Fa | 1995 |
Neutrophil infiltration does not contribute to the ulcerogenic effects of indomethacin in the rat gastric antrum.
Topics: Animals; Female; Indomethacin; Neutrophils; Pyloric Antrum; Radioimmunoassay; Rats; Rats, Sprague-Da | 1994 |
Inhibition of inflammation and gastric damage in rats by copper (II) complexes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Behavior, Animal; Carrageenan; | 1995 |
L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats.
Topics: Analgesics; Animals; Cyclooxygenase Inhibitors; Indans; Indomethacin; Male; Piroxicam; Rats; Rats, S | 1994 |
Gastric blood flow in ulcer diseases.
Topics: Animals; Blood Flow Velocity; Carbachol; Dogs; Ethanol; Gastric Acid; Gastric Mucosa; Hemoglobins; H | 1995 |
Gastroprotective effect of aqueous extract of Cistus incanus L. in rats.
Topics: Animals; Ethanol; Flavonoids; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Male; Medicine, Tradi | 1995 |
Effect of zinc on the anti-inflammatory and ulcerogenic activities of indometacin and diclofenac.
Topics: Analysis of Variance; Animals; Diclofenac; Drug Interactions; Indomethacin; Male; Rats; Stomach Ulce | 1995 |
Effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion in pylorus-ligated rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; Gastric Acid; Gastric Mucos | 1995 |
Effects of the acetylene compound from Atractylodes rhizome on experimental gastric ulcers induced by active oxygen species.
Topics: Acetylene; Administration, Oral; Alkynes; Animals; Anti-Ulcer Agents; Disease Models, Animal; Diynes | 1994 |
Synthesis and pharmacological evaluation of oligoethylene ester derivatives as indomethacin oral prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromatography, High Pressure Liquid; | 1994 |
Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Blood Flow Velocity; Dogs; Gastric Acid; Gastric Mucosa; Guanid | 1994 |
Enhancement of gastric mucosal blood flow by beta-3 adrenergic agonists prevents indomethacin-induced antral ulcer in the rat.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Female; Gastric Mucosa; Guinea Pigs; Heart Rate; | 1994 |
[The effect of dopamine and PGI2 on indomethacin and alcohol-induced gastric lesions in rats of various ages in relation to gastric vascular permeability and HCl secretion].
Topics: Aging; Animals; Capillary Permeability; Dopamine; Epoprostenol; Ethanol; Gastric Acid; Gastric Mucos | 1993 |
Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins.
Topics: Animals; Edema; Ethanol; Gastric Mucosa; Gastrointestinal Hemorrhage; Indomethacin; Male; Prostaglan | 1994 |
YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepines; Duodenal Ulcer; Epirizole; Ethanol; Famotidine; Gastric | 1994 |
Leukotrienes do not contribute to the pathogenesis of indomethacin-induced ulceration of the gastric antrum in the re-fed rat.
Topics: Administration, Oral; Animals; Benzopyrans; Female; Indazoles; Indoles; Indomethacin; Injections, Su | 1994 |
Synthesis and anti-inflammatory properties of 1,2-dialkoxy-4-(3-dimethylaminopropionyl)benzenes and their 5-halogeno derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Edema; Foot Inju | 1994 |
Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats.
Topics: Animals; Atropine; Deoxyglucose; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Ind | 1994 |
A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats.
Topics: Animals; Aspirin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Ethanol; Gastric Mucosa; Hy | 1994 |
The differential roles of sympathetic nerve activity in the pathogenesis of antral and corpus lesions induced by indomethacin in rats.
Topics: Animals; Blood Glucose; Catecholamines; Gastric Mucosa; Indomethacin; Insulin; Male; Oxidopamine; Pr | 1994 |
Antiulcer effect of naringin on gastric lesions induced by ethanol in rats.
Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Dinoprostone; Ethanol; Flavanones; Flavonoids; Gastric Mu | 1994 |
Influences of urethane anesthesia on indomethacin-induced gastric mucosal lesions in rats. Relation to blood glucose levels.
Topics: Anesthesia, General; Animals; Blood Glucose; Gastric Acid; Gastric Mucosa; Gastrointestinal Motility | 1994 |
Mucus synthesis and sulfhydryl groups in cytoprotection mediated by dehydroleucodine, a sesquiterpene lactone.
Topics: Animals; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Indomethacin; Lactones; Male; Mucus; Plants, Me | 1994 |
Biochemical evaluation of the antiulcerogenic effect of Cauvery-100 (an ayurvedic formulation) in rats.
Topics: Animals; Anti-Ulcer Agents; Antidiarrheals; Gastric Juice; Hexosamines; Hexoses; Indomethacin; Male; | 1994 |
Aminopyrazinyl derivatives: synthesis and evaluation of antiinflammatory and related activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Edema; Femal | 1994 |
Protection against necrotizing agents-induced gastric lesions in rats. Unrelated to inhibition of gastric motility.
Topics: Animals; Ethanol; Female; Gastrointestinal Motility; Hydrochloric Acid; Indomethacin; Male; Papaveri | 1994 |
Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indometacin in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Free Radicals; Gastric Mucosa; Indomethacin; Lipid Peroxidation | 1993 |
Protective effect of Swertia chirata against indomethacin and other ulcerogenic agent-induced gastric ulcers.
Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, | 1993 |
Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals.
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Benzimidazoles; Duodenal Ulcer; Epirizole; Ethano | 1993 |
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response | 1993 |
Green banana protection of gastric mucosa against experimentally induced injuries in rats. A multicomponent mechanism?
Topics: Acute Disease; Animals; Chronic Disease; Ethanol; Fruit; Gastric Mucosa; Indomethacin; Male; Models, | 1993 |
Potentiating interactions between medullary serotonin and thyrotropin-releasing hormone-induced gastric erosions in rats.
Topics: Animals; Cold Temperature; Indomethacin; Injections; Injections, Intravenous; Ketanserin; Male; Medu | 1993 |
Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage.
Topics: Administration, Oral; Animals; Arthritis; Aspirin; Female; Gastric Mucosa; Indoles; Indomethacin; In | 1993 |
The rat gastric phospholipids: increased in ulcerated mucosa and decreased after healing.
Topics: Animals; Chronic Disease; Fasting; Fatty Acids; Gastric Mucosa; Indomethacin; Male; Phospholipids; P | 1993 |
Endotoxin protects the gastric mucosa against ulcerogenic stimuli.
Topics: Animals; Endotoxins; Escherichia coli; Ethanol; Gastric Acid; Gastric Emptying; Gastric Mucosa; Indo | 1993 |
Role of oxygen radicals in indomethacin-induced gastric mucosal microvascular injury in rats.
Topics: Animals; Capillary Permeability; Catalase; Endothelium, Vascular; Gastric Mucosa; Indomethacin; Lipi | 1993 |
Multiple mediators and mechanisms are involved in the adaptive cytoprotection provided by certain mild irritants.
Topics: Animals; Arginine; Gastric Mucosa; Indomethacin; Irritants; Male; Nitric Oxide; Nitroarginine; Prost | 1993 |
A role for calcitonin gene-related peptide in protection against gastric ulceration.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Gastric Mucosa; Indomethacin; Male; Neurons, Af | 1994 |
Antiulcer and gastroprotective effects of quercetin: a gross and histologic study.
Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Ethanol; Gastric Mucosa; Hexosamines; Indomethacin; Male; | 1994 |
Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Benzimid | 1993 |
Effect and mechanism of sucralfate on healing of acetic acid-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Animals; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred | 1993 |
Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Citrates; Dogs; Ethanol; Female; Ferrets; Gastric Acid; Gastric | 1993 |
Investigations of indomethacin-induced gastric ulcer in rats.
Topics: Animals; Dinoprostone; Eicosanoids; Epoprostenol; Gastric Mucosa; Indomethacin; Leukotriene Antagoni | 1993 |
New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena | 1993 |
Do infiltrating neutrophils contribute to the pathogenesis of indomethacin induced ulceration of the rat gastric antrum?
Topics: Animals; Cell Movement; Indomethacin; Leukocyte Count; Leukotriene B4; Neutrophils; Pyloric Antrum; | 1993 |
Pharmacological and pharmaceutical properties of freeze-dried formulations of egg albumin, indomethacin, olive oil, or fatty acids.
Topics: Administration, Oral; Animals; Biological Availability; Carrageenan; Drug Carriers; Edema; Fatty Aci | 1993 |
Synthesis and evaluation of morpholinoalkyl ester prodrugs of indomethacin and naproxen.
Topics: Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pres | 1993 |
Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats.
Topics: Animals; Chronic Disease; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Phosp | 1993 |
An animal model of longitudinal ulcers in the small intestine induced by intracolonically administered indomethacin in rats.
Topics: Animals; Cecal Diseases; Colon; Disease Models, Animal; Duodenal Ulcer; Indomethacin; Intestinal Muc | 1993 |
Mechanism by which indomethacin delays gastric ulcer healing in the rat: inhibited contraction of the ulcer base.
Topics: Acetates; Acetic Acid; Animals; Connective Tissue; Gastric Mucosa; Indomethacin; Male; Muscle Contra | 1993 |
Effects of indomethacin and prednisolone on the different stages of healing of acetic acid-induced gastric ulcers in the rat.
Topics: Acetates; Acetic Acid; Animals; Collagen; Connective Tissue; Gastric Mucosa; Indomethacin; Male; Pre | 1993 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blotting, Northern; Blotting, We | 1995 |
NSAID-induced delay in gastric ulcer healing is not associated with decreased epithelial cell proliferation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Epithelial Cells; Epitheli | 1995 |
Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antilymphocyte Serum; Etodolac; Gastric Mucosa; Ga | 1995 |
Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines.
Topics: Animals; Arginine; Chronic Disease; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Efl | 1995 |
Indomethacin interferes with epidermal growth factor binding and proliferative response of gastric KATO III cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cell Survival; Cells, Cultured; Epidermal Gr | 1995 |
Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell | 1995 |
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole; | 1995 |
Anti-ulcer activity of higher primary alcohols of beeswax.
Topics: Administration, Oral; Alcohols; Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Etha | 1995 |
Effect of 10% ethanol and sofalcone on prostaglandin E2 content, mucus gel thickness, and experimental ulcers in the stomach of developing rats.
Topics: Aging; Animals; Animals, Newborn; Anti-Ulcer Agents; Chalcone; Chalcones; Dinoprostone; Dose-Respons | 1996 |
Effect of vitamin E and selenium on hypothermic restraint stress and chemically-induced ulcers.
Topics: Animals; Antioxidants; Cold Temperature; Hydrochloric Acid; Immobilization; Indomethacin; Rats; Rats | 1996 |
Anti-inflammatory and analgesic activity of Baccharis trimera: identification of its active constituents.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanols; Carra | 1996 |
Aggravating process induced by indomethacin on chronic gastric lesion in rat. Role of polymorphonuclear leucocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Hydroxyurea; Indomethacin | 1995 |
Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Benzimidazoles; Indomethacin; Male; Omeprazole; Peroxidase; Rats; Rats, | 1996 |
Effects of the novel histamine H2-receptor antagonist (+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2-[[[5- (methylamino)methyl-2-furyl]methyl]thio]ethyl]-2-(methylsulfonyl) guanidine on gastric secretion and gastroduodenal ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Epirizole; Gastric Acid; Gastric Mucos | 1996 |
Mast cells do not contribute to nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rodents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Dexa | 1996 |
Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Capsaicin; Ethanol; Gastric Mucosa; Indomethacin; Male; Neur | 1996 |
Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Gastroi | 1996 |
The importance of gastric emptying and mucosal folds in the adaptive cytoprotection of mild irritants in rats.
Topics: Adaptation, Physiological; Animals; Anti-Ulcer Agents; Ethanol; Gastric Emptying; Gastric Mucosa; Hy | 1995 |
The role of acid in the pathogenesis of indomethacin-induced gastric antral ulcers in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cimetidine; Female; Gastric Aci | 1996 |
Influence of age on natural and delayed healing of experimentally-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male; | 1996 |
Omeprazole prevents indomethacin-induced gastric ulcers in rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Enzyme Inhibitors; Gastric Acid; Gas | 1996 |
A study of the antiulcer mechanisms of propranolol in rats.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Ulcer Agents; Blood Pressure; Ethanol; Gastric Mucosa; He | 1996 |
Cytoprotective activity of cisapride on experimental gastric mucosal lesions induced by ethanol. Role of endogenous prostaglandins.
Topics: Animals; Anti-Ulcer Agents; Cisapride; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Mu | 1996 |
Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Indomethacin; Male; Neu | 1996 |
Pharmacokinetics of indomethacin ester prodrugs: gastrointestinal and hepatic toxicity and the hydrolytic capacity of various tissues in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Li | 1996 |
Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat.
Topics: Animals; Aspirin; Benzofurans; Ethanol; Female; Gastritis; Indomethacin; Iodoacetamide; Leukotriene | 1996 |
Protective effect of taurine on indomethacin-induced gastric mucosal injury.
Topics: Adult; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; | 1996 |
Effect of fish oil on indometacin-induced gastric lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Diet; Fish Oils; Gastric Mucosa; Indomethacin; Male; Mucus; Olive Oil; P | 1995 |
Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillaries; Cell Movement; Fasting; Gastric Mucos | 1996 |
[Effects of Cuban analog (SWR-104SA), a new histamine H2 receptor antagonist, on gastric acid secretion and experimental ulcer formation].
Topics: Animals; Dioxolanes; Ethanol; Gastric Acid; Gastrointestinal Motility; Guinea Pigs; Histamine H2 Ant | 1996 |
Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ethanol; Gastric Mucosa; Indomethacin; Male; Polyc | 1996 |
Anti-inflammatory and antiulcer activity of Teucrium buxifolium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Experimental; Carrag | 1997 |
Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism | 1997 |
Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats.
Topics: Amyloid; Animals; Dose-Response Relationship, Drug; Ethanol; Gastric Acidity Determination; Gastric | 1997 |
Gastric motility and mucosal ulcerogenic responses induced by prokinetic drugs in rats under prostaglandin-deficient conditions.
Topics: Animals; Cisapride; Dose-Response Relationship, Drug; Gastric Acid; Gastric Emptying; Gastric Mucosa | 1997 |
Gastric ECL-cell hyperplasia produces enhanced basal and stimulated gastric acid output but not gastric erosion formation in the rat.
Topics: Animals; Carbachol; Enterochromaffin Cells; Female; Gastric Acid; Gastric Mucosa; Histamine; Hyperpl | 1997 |
Investigations on the protective action of Condonopsis pilosula (Dangshen) extract on experimentally-induced gastric ulcer in rats.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Drugs, Chinese Herbal; Duodenum; Gastric Acid; Gastric Muco | 1997 |
Increased expression of transforming growth factor-beta1 during gastric ulcer healing in rats.
Topics: Acetic Acid; Alprostadil; Animals; Blotting, Northern; Extracellular Matrix Proteins; Gastric Mucosa | 1997 |
Bosentan, a novel synthetic mixed-type endothelin receptor antagonist, attenuates acute gastric mucosal lesions induced by indomethacin and HCl in the rat: role of endogenous endothelin-1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bosentan; Endothelin Receptor Antagonists; Endothe | 1997 |
Gastroprotective effect of malotilate in indomethacin- and ethanol-induced gastric mucosal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Indome | 1996 |
Cell kinetic events in early indomethacin-induced gastrointestinal ulcerations in the rat.
Topics: Animals; Biopsy; Cell Division; Dinoprostone; Dose-Response Relationship, Drug; Gastric Fundus; Gast | 1997 |
Gastric mucosal injury by nonsteroidal anti-inflammatory drugs is reduced by (R)-alpha-methylhistamine and its pro-drugs in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Acid; Gastric Mucosa; Histamine A | 1997 |
Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen | 1997 |
Effect of quinacrine, a phospholipase A2 inhibitor on stress and chemically induced gastroduodenal ulcers.
Topics: Animals; Cyclooxygenase Inhibitors; Cysteamine; Duodenal Ulcer; Enzyme Inhibitors; Ethanol; Female; | 1997 |
Flavonoid-induced gastroprotection in rats: role of blood flow and leukocyte adherence.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Disease Models, Animal; Flavonoids; | 1997 |
Comparative evaluation of the severity of gastric ulceration by solid dispersions and coprecipitates of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Precipitation; Indomethacin; Male; Rats; | 1997 |
Synthesis of amides with anti-inflammatory and analgesic activities.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Gas Chromatogr | 1997 |
Analysis of pathogenic elements involved in gastric lesions induced by non-steroidal anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Deoxyglucose; Disease Models, Ani | 1997 |
Intracisternal injection of basic fibroblast growth factor reduces the severity of gastric mucosal lesions evoked by ethanol in rats.
Topics: Animals; Anti-Ulcer Agents; Brain; Cisterna Magna; Disease Models, Animal; Ethanol; Fibroblast Growt | 1997 |
The indomethacin-induced gastric mucosal damage in rats. Effect of gastric acid, acid inhibition, capsaicin-type agents and prostacyclin.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diterpenes; E | 1997 |
Protective effect of zinc gluconate on chemically induced gastric ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Biological Transport; Eth | 1997 |
Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers.
Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomar | 1997 |
[A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump].
Topics: Acetates; Animals; Anti-Ulcer Agents; Disease Models, Animal; Indomethacin; Infusion Pumps, Implanta | 1997 |
Changes in sulfated macromolecules produced in vivo during normal and indomethacin-delayed ulcer healing in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Glycosaminoglycans; G | 1997 |
Study of the antisecretory and antiulcer mechanisms of a new indenopirydazinone derivative in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bethanechol; Female; Gastric Ac | 1997 |
[Comparison of anti-ulcer properties of OF-900, OF-743 and their combination in various models of stomach ulcer induction in rats].
Topics: Animals; Anti-Ulcer Agents; Drug Therapy, Combination; Ethanol; Indomethacin; Male; Rats; Stomach Ul | 1997 |
Kinetics of fibroblasts in ulcer healing in rats: interference with indomethacin.
Topics: Acetic Acid; Actins; Animals; Apoptosis; Culture Techniques; Cyclooxygenase Inhibitors; Disease Mode | 1997 |
Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Caustics; Disease Models, Anima | 1997 |
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 1997 |
Circadian reactivity rhythm of rat gastric mucosa to restraint-cold stress and indomethacin: temporal variation in the protective effect of iloprost.
Topics: Animals; Anti-Ulcer Agents; Circadian Rhythm; Cold Temperature; Disease Models, Animal; Drug Adminis | 1997 |
Increase in pH and prevention of gastropathy induced by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Hydrogen-Ion Concentration; Ind | 1997 |
Effect of cold-stress and indomethacin on the biosynthesis of gastric sulfated mucin in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Cold Temperature; Ethanol; Gastric Mucin | 1997 |
Platelet-derived growth factor reverses the effects induced by NSAIDs on ulcer healing.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Gastric Mucosa; Granulatio | 1997 |
ICAM-1 and P-selectin expression in a model of NSAID-induced gastropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Indomethacin; Intercellular Adhesi | 1998 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1998 |
Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera--involvement of 5-lipoxygenase pathway.
Topics: Animals; Anti-Ulcer Agents; Arachidonate 5-Lipoxygenase; Aspirin; Ethanol; Female; Gastric Mucosa; G | 1998 |
Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara.
Topics: Animals; Anti-Ulcer Agents; Cell Line; Cell Survival; Cimetidine; Diterpenes; Diterpenes, Clerodane; | 1998 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dicl | 1998 |
Nonsteroidal anti-inflammatory drugs may delay the repair of gastric mucosa by suppressing prostaglandin-mediated increase of hepatocyte growth factor production.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Cholera Toxin; Cyclic AMP; Cyclooxygenase 1; C | 1998 |
Mechanism by which indomethacin delays the healing of acetic acid-induced ulcers in rats. Role of neutrophil antichemotactic and chemotactic activities.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotactic Factors; Dinoprostone; Ga | 1998 |
SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity.
Topics: Animals; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Ethylmaleimide; Female; Fl | 1998 |
Effects of keratinocyte growth factor (KGF) on gut growth and repair.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Digestive System; Dose-Response Rel | 1998 |
Gastric cytoprotective activity of dehydroleucodine in rats. Role of nitric oxide.
Topics: Animals; Anti-Ulcer Agents; Arginine; Central Nervous System Depressants; Cyclooxygenase Inhibitors; | 1998 |
Biochemical and pharmacological characteristics of 3-butyryl-8-methoxy-4-[(2-thiophenyl)amino]quinoline, a new proton-pump inhibitor, in rabbit gastric microsomes and in rats.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Acid; Gastric | 1998 |
Prostaglandin, tumor necrosis factor alpha and neutrophils: causative relationship in indomethacin-induced stomach injuries.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Resp | 1998 |
Synthesis of some novel pyrazole derivatives as potential antiinflammatory agents with minimum ulcerogenic activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Foot; Gastric Mucosa; Indometh | 1998 |
Involvement of ornithine decarboxylase and polyamines in epidermal growth factor-induced recovery of gastric mucosa from gastric lesions provoked by stress.
Topics: Animals; Anti-Ulcer Agents; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Gastric Mucosa | 1998 |
Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats.
Topics: Animals; Balsams; Disease Models, Animal; Ethanol; Fabaceae; Gastric Acid; Gastric Mucosa; Indometha | 1998 |
Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.
Topics: Animals; Cyclooxygenase 2; Dinoprostone; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandi | 1998 |
Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Calcium; Gastric Mucos | 1998 |
Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo | 1998 |
Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; C | 1998 |
Investigation on the mechanisms involved in the central protective effect of amylin on gastric ulcers in rats.
Topics: Amyloid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Calcitonin; Enzyme Inh | 1998 |
[Effect of T-593 on gastric bleeding and lesions induced by indomethacin and water-immersion stress in rats: improving effect of T-593 on reduced gastric mucosal blood flow in rats].
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Gastric Mucosa; Guanidines; Histamine H2 Antag | 1998 |
Protective effects of oleanolic acid oligoglycosides on ethanol- or indomethacin-induced gastric mucosal lesions in rats.
Topics: Animals; Ethanol; Gastric Acid; Gastric Mucosa; Glycosides; Indomethacin; Male; Oleanolic Acid; Phyt | 1998 |
Protective role of melatonin and the pineal gland in modulating water immersion restraint stress ulcer in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Free Radical Scavengers; Indomethacin; Male; Melatonin; Pineal G | 1998 |
Effect of roxatidine bismuth citrate (MX1) against acetylsalicylic acid- and indomethacin-induced gastric mucosal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Drug Combinations; Dru | 1998 |
Immunosuppressive cells in bone marrow of patients with stomach cancer.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Bone Marrow; Bone Marrow Cells; Cell Adhesion; Cytotoxicity, | 1998 |
Protection by Rhinax in various models of ulceration in rats.
Topics: Animals; Gastric Acid; Gastric Mucins; Hydrochloric Acid; Indomethacin; Ligation; Male; Medicine, Ay | 1998 |
Relationship between vascular endothelial growth factor and angiogenesis in spontaneous and indomethacin-delayed healing of acetic acid-induced gastric ulcers in rats.
Topics: Acetic Acid; Animals; Cyclooxygenase Inhibitors; Endothelial Growth Factors; Gastric Mucosa; Indomet | 1998 |
Anti-inflammatory and ulcerogenic effects of 3-(N,N-diethylamino) propylindometacin HCl.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Indomethacin; Male; Prodrugs; Rats; Rats, S | 1997 |
[Role of interleukin-8 in indomethacin-induced stomach ulcer in rats].
Topics: Animals; Indomethacin; Interleukin-8; Male; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1997 |
Role of antioxidants in gastric mucosal damage induced by indomethacin in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Capillary Perm | 1998 |
Protective effect of melatonin on indomethacin-induced gastric injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Free Radical Scavengers; Gastric Mucosa; G | 1999 |
Characterization of antisecretory and antiulcer activity of CR 2945, a new potent and selective gastrin/CCK(B) receptor antagonist.
Topics: Animals; Anti-Anxiety Agents; Anti-Ulcer Agents; Benzodiazepines; Benzodiazepinones; Calcium; Cats; | 1999 |
Naloxone is protective against indomethacin-induced gastric damage in cholestatic rats.
Topics: Animals; Cholestasis; Dose-Response Relationship, Drug; Gastric Mucosa; Indomethacin; Male; Naloxone | 1999 |
Anti-ulcerogenic properties of endothelin receptor antagonists in the rat.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Endothelin Receptor Antagonists; Indomethacin; M | 1999 |
Role of nitric oxide in indomethacin-induced gastric mucosal dysfunction in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chelating Agents; Edetic Acid; Enzyme Inhibitors; | 1999 |
Cytokine-induced neutrophil chemoattractants in healing of gastric ulcers in rats: expression of >40-kDa chemoattractant in delayed ulcer healing by indomethacin.
Topics: Animals; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Chemotaxis, Leukocyte; Growth Substa | 1999 |
Antithrombin prevents stress-induced gastric mucosal injury by increasing the gastric prostacyclin level in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Albumins; Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory | 1999 |
Dual effect of female sex steroids on drug-induced gastroduodenal ulcers in the rat.
Topics: Animals; Capillary Permeability; Cysteamine; Duodenal Ulcer; Estradiol; Female; Gastric Mucosa; Indo | 1999 |
Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide.
Topics: Animals; Arthritis, Experimental; Body Weight; Dinoprostone; Ethanol; Gastric Acid; Indomethacin; Ma | 1999 |
Gastroprotective mechanism of lafutidine, a novel anti-ulcer drug with histamine H2-receptor antagonistic activity.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroida | 1999 |
A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inh | 1999 |
Endothelin-1, interleukin-4 and nitric oxide synthase modulators of gastric mucosal injury by indomethacin: effect of antiulcer agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Benzenesulfonates; E | 1999 |
Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Administration, Oral; Animals; Anti-Ulcer Agents; Capsai | 1999 |
1',1'-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: a novel, orally effective cannabinoid with analgesic and anti-inflammatory properties.
Topics: Administration, Oral; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Ag | 1999 |
Antiulcer effect of the N- and O-beta-D-glucopyranosides of 5-aminosalicylic acid.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Glucoside | 1999 |
Some studies on the rodenticidal action of indomethacin.
Topics: Administration, Oral; Animals; Bile Ducts; Body Weight; Cholestyramine Resin; Diazepam; Drug Interac | 1999 |
Human apolipoprotein A-IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice.
Topics: Age Factors; Animals; Apolipoproteins A; Gastric Acid; Gastric Mucosa; Gastrins; Humans; Indomethaci | 1999 |
Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats.
Topics: Acetates; Administration, Oral; Animals; Colitis; Deferiprone; Disease Models, Animal; Gastric Mucos | 1999 |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 1999 |
Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip.
Topics: Animals; Asteraceae; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Plant Extracts; Plants, Me | 1999 |
Gastric mucosal cellular changes induced by indomethacin (NSAID) in male albino rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Indomethacin; Male; Peptic Ulcer H | 1999 |
Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Gas | 2000 |
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 1999 |
Difference between the effect of acute and chronic surgical vagotomy on the cytoprotective action of atropine against indomethacin-induced mucosal lesions on the gastrointestinal tract in rats.
Topics: Animals; Atropine; Capillary Permeability; Dose-Response Relationship, Drug; Female; Gastric Mucosa; | 1999 |
Preparation and pharmacodynamic evaluation of liposomes of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Drug Carriers; Edema; | 2000 |
Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine.
Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Disease Models, Animal; Gastric Juice; Histamine H2 A | 2000 |
Endothelial changes precede mucosal ulceration induced by indomethacin: an experimental study in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endothelium, Vascular; Female; Indomethacin; Micro | 2000 |
The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer.
Topics: Animals; Antioxidants; Cytoprotection; Euphorbiaceae; Female; Free Radical Scavengers; Fruit; Hexosa | 2000 |
The roles of nitric oxide and prostaglandins in alterations of ulcerogenic and healing responses in adjuvant-induced arthritic rat stomachs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Central Nervous System De | 2000 |
The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; Chalcone; Chalco | 2000 |
Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Aspirin; Dothiep | 2000 |
Matrix metalloproteinases 2 and 9 in indomethacin-induced rat gastric ulcer.
Topics: Animals; Blotting, Northern; In Situ Hybridization; Indomethacin; Male; Matrix Metalloproteinase 2; | 2000 |
Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind.
Topics: Animals; Anti-Ulcer Agents; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Fruit; In | 2000 |
Cytoprotective effect of rabeprazole against ethanol-induced gastric mucosal damage: possible involvement of nitric oxide.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2000 |
Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Central Nervous System Depressa | 2000 |
Antiulcerogenic effects of Tylophora conspicua in male rats.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gas | 2000 |
Interaction between NSAIDs and steroid in rat stomach: safety of nimesulide as a preferential COX-2 inhibitor in the stomach.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cycloo | 2000 |
[Celecoxib vs indomethacin and acute gastric lesions in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Digestive Sy | 2000 |
Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats.
Topics: Anti-Ulcer Agents; Antidiarrheals; Gastrointestinal Motility; Indomethacin; Liliaceae; Methanol; Pla | 2000 |
Evaluation of the antiulcerogenic activity of friedelan-3beta-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae).
Topics: Animals; Anti-Ulcer Agents; Drug Evaluation; Gas Chromatography-Mass Spectrometry; Indomethacin; Mag | 2000 |
Antiulcer effectiveness of Maytenus aquifolium spray dried extract.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Indomethacin; Male; Phytotherapy; Plant | 2000 |
The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat.
Topics: Adrenergic alpha-Antagonists; Amyloid; Animals; Anti-Ulcer Agents; Calcitonin Gene-Related Peptide; | 2000 |
Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats.
Topics: Animals; Asteraceae; Cyclohexanes; Disease Models, Animal; Indomethacin; Male; Methanol; Methylene C | 2000 |
Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 2; Cycloox | 2000 |
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves.
Topics: 6-Ketoprostaglandin F1 alpha; Adaptation, Physiological; Anesthesia; Animals; Anti-Inflammatory Agen | 2001 |
Role of mucus reduction and luminal acid elevation in increased susceptibility of stomach to nonsteroidal antiinflammatory drug-induced injury in arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Dinoprostone; Do | 2000 |
Nitric oxide donating compounds inhibit HCl-induced gastric mucosal lesions mainly via prostaglandin.
Topics: 16,16-Dimethylprostaglandin E2; Administration, Oral; Animals; Gastric Mucosa; Hydrochloric Acid; In | 2001 |
The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetina | 2001 |
Effect of methanolic extract of Cassia nigricans leaves on rat gastrointestinal tract.
Topics: Animals; Anti-Ulcer Agents; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Ethanol; Gastroi | 2001 |
Diazoxide, a K(ATP) opener, accelerates restitution of ethanol or indomethacin-induced gastric ulceration in rats independent of polyamines.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diazoxide; Ethanol; Glyburide; Indo | 2001 |
Delayed healing of gastric ulcers in adjuvant arthritis rats: role of acid secretion and basic fibroblast growth factor.
Topics: Animals; Arthritis, Rheumatoid; Blotting, Western; Disease Models, Animal; Fibroblast Growth Factors | 2001 |
Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice.
Topics: Adaptation, Physiological; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; C | 2001 |
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cycloo | 2001 |
Rat as model for studying behavior effects of hCG.
Topics: Animals; Anxiety; Behavior, Animal; Chorionic Gonadotropin; Electroencephalography; Electromyography | 2001 |
Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrier Pro | 2001 |
Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Disease Models, An | 2001 |
Medicinal flowers. III. Marigold. (1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis.
Topics: Animals; Anti-Ulcer Agents; Blood Glucose; Calendula; Carbohydrate Sequence; Chemical Phenomena; Che | 2001 |
Effect of centrally administered prolactin on gastric and duodenal ulcers in rats.
Topics: Acetic Acid; Animals; Chronic Disease; Cysteamine; Duodenal Ulcer; Ethanol; Gastric Acid; Gastric Ac | 2001 |
Antiulcerogenic and analgesic effects of Maytenus aquifolium, Sorocea bomplandii and Zolernia ilicifolia.
Topics: Administration, Oral; Analgesics; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Gastric Mucosa; In | 2001 |
The antiulcerative effect of Thai Musa species in rats.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Female; Indomethacin; Pla | 2001 |
Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Gastri | 2001 |
Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats.
Topics: Animals; Heat-Shock Proteins; HSC70 Heat-Shock Proteins; HSP47 Heat-Shock Proteins; HSP70 Heat-Shock | 2001 |
Effects of diacerein on indomethacin-induced gastric ulceration.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dinoprostone; D | 2001 |
Effect of hyperprolactinaemia as induced by pituitary homografts under kidney capsule on gastric and duodenal ulcers in rats.
Topics: Acetic Acid; Acute Disease; Animals; Chronic Disease; Cysteamine; Duodenal Ulcer; Gastric Acid; Hype | 2001 |
Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cell Division; Cyclooxygenas | 2001 |
Antiulcerogenic effect of Hippophae rhamnoides L.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Famotidine; Fruit; Indomethacin; Male; Misoprost | 2001 |
Antiulcerogenic activity of crude ethanol extract and some fractions obtained from aerial parts of Artemisia annua L.
Topics: Animals; Anti-Ulcer Agents; Artemisia; Ethanol; Ethylmaleimide; Gas Chromatography-Mass Spectrometry | 2001 |
Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs.
Topics: Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Chronic Disease; Cysteamine; Disease Models, | 2001 |
TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury.
Topics: Alleles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cloning, Molecular; Gastri | 2002 |
The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat.
Topics: Animals; Epoprostenol; Female; Gastric Mucosa; Honey; Indomethacin; Mannitol; Osmolar Concentration; | 2001 |
The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, | 2002 |
Effects of Opuntia ficus-indica var. Saboten stem on gastric damages in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ethanol; Ficus; Gastric Juice; Gastric Mu | 2002 |
A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Central N | 2002 |
Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2002 |
Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice.
Topics: Animals; Central Nervous System Depressants; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 2002 |
Gastric ulcerogenic responses following barrier disruption in knockout mice lacking prostaglandin EP1 receptors.
Topics: Animals; Bridged Bicyclo Compounds; Caproates; Cytoprotection; Dinoprostone; Disease Models, Animal; | 2002 |
Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygen | 2002 |
Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inh | 2002 |
Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; | 2002 |
Antiulcerogenic activity of some sesquiterpene lactones isolated from Artemisia annua.
Topics: Animals; Anti-Ulcer Agents; Artemisinins; Asteraceae; Carbenoxolone; Cimetidine; Drug Interactions; | 2002 |
Antagonism of the gastrointestinal ulcerogenic effect of some nonsteroidal anti-inflammatory agents by sodium salicylate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relationship, Dru | 1976 |
Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers.
Topics: Administration, Oral; Animals; Aspirin; Carbachol; Depression, Chemical; Disease Models, Animal; Duo | 1977 |
Inhibitors of gastric lesions in the rat.
Topics: Animals; Aspirin; Disease Models, Animal; Female; Glutamine; Histamine Antagonists; Indomethacin; Li | 1978 |
Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats.
Topics: Animals; Disease Models, Animal; Female; Gastric Juice; Hydrogen-Ion Concentration; Indomethacin; Ma | 1978 |
A comparative study of the effects of prostaglandins and H2-receptor antagonists on gastric acid secretion, mucosal blood flow and ulcer formation.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Constipation; Dogs; Female; Gastric Mucosa; Gastrointestina | 1979 |
Gastric mucosal injury from common drugs.
Topics: Adrenal Cortex Hormones; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; G | 1978 |
A new anti-inflammatory derivative of imidazole which is less ulcerogenic than indomethacin in rats.
Topics: Animals; Anti-Inflammatory Agents; Biological Availability; Chemical Phenomena; Chemistry; Drug Eval | 1979 |
The action of salmon calcitonin on indomethacin-induced gastric ulceration in the mouse [proceedings].
Topics: Animals; Calcitonin; Indomethacin; Mice; Salmon; Stomach Ulcer | 1979 |
Influence of fasting and cimetidine on the relationship between ulcerogenic and anti-inflammatory properties of indomethacin.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cimetidine; Drug Interactions; Fasting; Fatty Acids, | 1979 |
Correlation between the rise in acute phase proteins and histological evidence of ulceration in the rat following indomethacin treatment [proceedings].
Topics: Animals; Glycoproteins; Indomethacin; Male; Rats; Stomach Ulcer | 1979 |
The action of salmon calcitonin on indomethacin-induced gastric ulceration in the rat [proceedings].
Topics: Animals; Calcitonin; Indomethacin; Rats; Salmon; Stomach Ulcer | 1979 |
Interaction of salicylates and other non-steroidal anti-inflammatory agents in rats as shown by gastro-ulcerogenic and anti-inflammatory activities, and plasma concentrations.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Drug Interactions; Gastric Mucosa; Indometh | 1979 |
Effect of indomethacin on blood flow distribution in the stomach of cats with acute gastric ulcer.
Topics: Acute Disease; Animals; Blood Pressure; Cardiac Output; Female; Gastric Mucosa; Heart Rate; Indometh | 1979 |
Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat.
Topics: Aluminum Hydroxide; Amylopectin; Animals; Anti-Ulcer Agents; Atropine; Chlorpromazine; Hexamethonium | 1979 |
The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat.
Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Animals; Cortisone; Desoxycorticosterone; Epinephrin | 1979 |
[Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)].
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Digestive Sy | 1979 |
Studies on indomethacin-induced gastric mucosal erosions and their inhibition by 16, 16 dimethyl prostaglandin E2 in the rat [proceedings].
Topics: Animals; In Vitro Techniques; Indomethacin; Prostaglandins E; Rats; Stomach Ulcer | 1977 |
The gastric mucosal microcirculation during erosion formation in the rat.
Topics: Animals; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Microcirculation; Rats; Regional Blood Flo | 1977 |
Gastro-colic fistula secondary to benign gastric ulceration.
Topics: Aged; Colonic Diseases; Female; Gastric Fistula; Humans; Indomethacin; Intestinal Fistula; Peptic Ul | 1978 |
Influence of surgical sympathectomy on gastric secretion and ulceration in rats.
Topics: Acetates; Animals; Aspirin; Digestive System; Gastric Juice; Indomethacin; Male; Rats; Reserpine; Se | 1978 |
Effects of cold or restraint on incidence of gastric ulceration induced in rats by ulcerogenic drugs.
Topics: Animals; Aspirin; Cimetidine; Cold Temperature; Female; Histamine; Indomethacin; Male; Phenylbutazon | 1978 |
Resistance of the guinea pig to indomethacin ulcerogenesis.
Topics: Animals; Drug Resistance; Duodenal Ulcer; Guinea Pigs; Indomethacin; Lethal Dose 50; Male; Peptic Ul | 1978 |
Release of inflammatory mediators into the gastric wall of rats with acute acetic acid induced ulcer.
Topics: Acetates; Acute Disease; Animals; Capillary Permeability; Gastric Mucosa; Gastritis; Indomethacin; M | 1978 |
Aspirin- and indomethacin-induced ulcers and their antagonism by antihistamines.
Topics: Animals; Aspirin; Cold Temperature; Corticosterone; Histamine Antagonists; Indomethacin; Male; Rats; | 1978 |
[Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Beclomethasone; Betamethasone; Betamethasone Valerate; C | 1978 |
[Comparative studies on gastrointestinal damage induced by non-steroidal anti-inflammatory drugs in rats (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dose-Response Relationship, Drug; Flurbiprofen; Indometh | 1978 |
Distention ulcer as a model for testing of drugs for ulcerogenic side effects.
Topics: Animals; Aspirin; Disease Models, Animal; Hydrochloric Acid; Indomethacin; Male; Rats; Stomach; Stom | 1978 |
Synthesis and gastrointestinal pharmacology of some 15- and 16- modified (+/-)-11-deoxyprostaglandins.
Topics: Animals; Chemical Phenomena; Chemistry; Constipation; Digestive System; Drug Evaluation, Preclinical | 1978 |
[Indomethacin and substance VUFB 12018 (Tropesin SPOFA). A comparison of their side effects on the gastrointestinal tract of rats].
Topics: Animals; Gastric Mucosa; Indomethacin; Male; Rats; Stomach Ulcer | 1978 |
Effects of various amino acids on indomethacin-induced gastric ulcers in rats.
Topics: Amino Acids; Animals; Indomethacin; Male; Rats; Stomach Ulcer | 1977 |
Effect of salbumatol on acute gastric ulceration induced by indomethacin in the rat.
Topics: Acute Disease; Albuterol; Animals; Indomethacin; Male; Rats; Stomach Ulcer | 1977 |
Prostaglandin and norepinephrine metabolism: effect of indomethacin on prostaglandin synthesis and norepinephrine turnover rate.
Topics: Animals; Depression, Chemical; Gastric Mucosa; Indomethacin; Male; Norepinephrine; Prostaglandins; R | 1977 |
The anti-inflammatory profile of proquazone.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Granuloma; Indomethaci | 1976 |
Effects of new synthetic analogues of prostaglandin E2 on gastric acid secretion and gastric ulceration.
Topics: Animals; Diarrhea; Dogs; Gastric Mucosa; Humans; Indomethacin; Male; Pentagastrin; Prostaglandins E; | 1976 |
Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Cortisone; Cyclohexanecarboxylic Acids; Disease Model | 1976 |
[Effects of various drugs on experimental ulcer in the rat].
Topics: Animals; Disease Models, Animal; Female; Indomethacin; Peptides; Pyridines; Rats; Stomach Ulcer | 1976 |
Gastric damage by drugs and the role of the mucosal barrier.
Topics: Animals; Aspirin; Dogs; Ethanol; Gastric Mucins; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans | 1976 |
Decreased incidence of indomethacin-induced gastric ulceration in rats by bile duct diversion.
Topics: Ampulla of Vater; Animals; Bile Ducts; Female; Indomethacin; Injections, Intraperitoneal; Male; Rats | 1975 |
Proceedings: Salbutamol: inhibition of gastric ulceration in the rat.
Topics: Albuterol; Animals; Indomethacin; Rats; Stomach; Stomach Ulcer | 1975 |
Floctafenine, a new non-narcotic analgesic.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Dextropropoxyphene; D | 1975 |
[Gastric ulcer induced in the rat by non-steroid anti-inflammatory agents and the synergic effect of exogenous histamine].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Drug Synergism; Flufenamic Acid; Histamine; Indomethacin | 1975 |
Some pharmacological properties of 2-aryl-1,3-indandione derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticoagulants; Antitussive Agents; Drug Evaluation, | 1975 |
Proceedings: Gastric acidity and the mechanisms by which prostaglandins prevent indomethacin-induced gastric erosions.
Topics: Animals; Gastric Juice; Indomethacin; Prostaglandins; Rats; Stomach Ulcer | 1975 |
Drugs and gastric damage.
Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and | 1976 |
Effect of sialoadenectomy on stomach lesions induced by indomethacin and ethanol in relation to gastric vascular permeability, the gastrin level and HCl secretion in rats.
Topics: Animals; Capillary Permeability; Epidermal Growth Factor; Ethanol; Gastrins; Hydrochloric Acid; Indo | 1992 |
[Effect of circadian rhythm on the action of acupuncture to prevent the formation of experimental gastric ulcer].
Topics: Acupuncture Therapy; Alprostadil; Animals; Circadian Rhythm; Dinoprost; Gastric Mucosa; Indomethacin | 1992 |
Studies on gastroprotection induced by capsaicin and papaverine.
Topics: Animals; Arginine; Capsaicin; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Nitroarginine; Pa | 1992 |
Influence of cloprostenol in the experimentally induced ulcer in rats.
Topics: Animals; Cloprostenol; Disease Models, Animal; Drug Evaluation, Preclinical; Indomethacin; Male; Rat | 1992 |
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; | 1992 |
Is acute surgical vagotomy an aggressor to gastric mucosa in pylorus ligated rats with and without indomethacin treatment?
Topics: Animals; Dinoprostone; Gastric Mucosa; Indomethacin; Pylorus; Rats; Rats, Sprague-Dawley; Stomach Ul | 1992 |
Correlation between the cytoprotective effect of beta-carotene and its gastric mucosal level in indomethacin (IND) treated rats with or without acute surgical vagotomy.
Topics: Animals; beta Carotene; Carotenoids; Chromatography, High Pressure Liquid; Female; Gastric Mucosa; I | 1992 |
Synthesis and gastroprotective activity of 4H-pyrido[1,2-a]pyrimidin-4-ones.
Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Decision Trees; Ethanol; Indomethacin; Pyrimidinon | 1992 |
Gastric anti-ulcerogenic drug effect. A possible mechanism of its molecular basis.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Cyclic AMP; Cyclic GMP; Epoprostenol; Female; Indomethacin; | 1992 |
Reduction of adverse effects of indomethacin by anti-allergic drugs in rat stomachs.
Topics: Animals; Gastric Acid; Gastric Mucosa; Histamine Antagonists; Histamine H1 Antagonists; Indomethacin | 1992 |
[Study on pilules of indomethacin--PEG 6000].
Topics: Animals; Drug Carriers; Gastric Acid; Indomethacin; Male; Polyethylene Glycols; Rats; Rats, Inbred S | 1992 |
Anti-inflammatory, analgesic, and antipyretic effects and gastrointestinal toxicity of the new anti-inflammatory drug N-(3-[3-(piperidinylmethyl)phenoxy]propyl)-carbamoylmethylthio ]ethyl 1-(p-chlorobenzoyl) 5-methoxy-2-methyl-3-indolylacetate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capillary Permeability; E | 1992 |
Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury.
Topics: Acute Disease; Animals; Blood Flow Velocity; Epidermal Growth Factor; Gastric Mucosa; Indomethacin; | 1992 |
Possible involvement of hyperinsulinemia and adrenergic activation in the pathogenesis of indomethacin-induced antral ulcers in nonfasted hamsters and refed rats.
Topics: Animals; Atropine; Cricetinae; Famotidine; Fasting; Indomethacin; Insulin; Male; Mesocricetus; Prazo | 1992 |
Effects of sulfhydryl-related compounds on indomethacin-induced gastric lesions in rats: role of endogenous sulfhydryls in the pathogenesis.
Topics: Animals; Gastric Acidity Determination; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strai | 1992 |
Synthesis and antiulcer activity of novel 5-(2-ethenyl substituted)-3(2H)-furanones.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Ethanol; Furans; Indomethacin; Male; Molecular Str | 1992 |
Effects of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on platelet aggregation and thrombosis in experimental animals.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Bridged Bicyclo Compounds; Cyclooxygenase | 1992 |
Role of nitric oxide and prostaglandins in sucralfate-induced gastroprotection.
Topics: Animals; Anti-Ulcer Agents; Arginine; Ethanol; Indomethacin; Male; Nitric Oxide; Nitroarginine; Pros | 1992 |
Steroid ulcers.
Topics: Animals; Indomethacin; Prednisolone; Rats; Stomach Ulcer; Wound Healing | 1992 |
Pharmacological profile of UP 5145-52, an original antiulcer and antisecretory agent.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Anti-Ulcer Agents; Dose-Response Relations | 1991 |
[The part of lysosomal enzymes in drug-induced ulcerogenesis].
Topics: Animals; Aspirin; Cathepsins; Deoxyribonucleases; Indomethacin; Lysosomes; Male; Phenylbutazone; Qui | 1991 |
Effect of unmodified eel calcitonin on gastric acid secretion and gastric ulcers in the rat.
Topics: Animals; Anti-Ulcer Agents; Calcitonin; Cold Temperature; Cystamine; Gastric Acid; Indomethacin; Mal | 1991 |
Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Gastric Acid; Gastric Mucosa; Histamine H1 Antagonist | 1991 |
Improvement of absorption rate of indomethacin and reduction of stomach irritation by alginate dispersions.
Topics: Administration, Oral; Adult; Alginates; Animals; Chemistry, Pharmaceutical; Dogs; Humans; Indomethac | 1991 |
Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing.
Topics: Adult; Aged; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell | 1990 |
Gastric mucosal protection induced by restraint and water-immersion stress in rats.
Topics: Animals; Atropine; Dinoprostone; Electric Stimulation; Ethanol; Gastric Mucosa; Immersion; Indometha | 1990 |
Momentum omentum!
Topics: Animals; Chronic Disease; Gastric Mucosa; Indomethacin; Omentum; Rats; Regional Blood Flow; Stomach | 1992 |
Antiulcerogenic effects of two Maytenus species in laboratory animals.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Cold Temperature; Gastric Acid | 1991 |
Intragastric pH in the gastroprotective and ulcer-healing activity of aluminum-containing antacids.
Topics: Acute Disease; Aluminum Hydroxide; Animals; Antacids; Chronic Disease; Drug Combinations; Ethanol; F | 1991 |
Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Atropine; Capillary Permeability; Free Radicals; Gastric Mu | 1991 |
Gastroprotective effect of nitrendipine on stress-induced gastric lesions in rats.
Topics: Animals; Cold Temperature; Dexamethasone; Female; Immobilization; Indomethacin; Male; Nitrendipine; | 1991 |
Dose-dependent effects of fentanyl on indomethacin-induced gastric damage.
Topics: Animals; Atropine; Butyrophenones; Dose-Response Relationship, Drug; Drug Combinations; Fentanyl; Ga | 1991 |
Possibilities to reduce the unwanted gastric side-effects of orally administered indomethacin in the rat.
Topics: Administration, Oral; Animals; Cysteine; Epoprostenol; Female; Gastrointestinal Hemorrhage; Indometh | 1991 |
Protection by acidified Maalox against indomethacin-induced gastric antral ulceration in hamsters.
Topics: Aluminum Hydroxide; Animals; Antacids; Cricetinae; Drug Combinations; Hydrogen-Ion Concentration; In | 1991 |
Protection against alcohol-induced gastric mucosal injury by nitecapone.
Topics: Animals; Anti-Ulcer Agents; Catechols; Ethanol; Gastric Mucosa; Hydrogen; Indomethacin; Male; Mucins | 1991 |
Reduction of non-steroidal anti-inflammatory drug induced gastric damage in the rat by soluble pepstatin derivatives.
Topics: Amino Acid Sequence; Animals; Female; Indomethacin; Molecular Sequence Data; Pepsin A; Pepstatins; R | 1991 |
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary | 1991 |
The effect of CV-3988 and CV-6209 on the acute gastric erosions of rats due to water-immersion and restraint stress.
Topics: Analysis of Variance; Animals; Gastric Mucosa; Immersion; Indomethacin; Male; Phospholipid Ethers; P | 1991 |
Effects of a new benzimidazole derivative, NC-1300-O-3, on gastric secretion and gastroduodenal lesions in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Benz | 1991 |
Interactions between the vascular peptide endothelin-1 and sensory neuropeptides in gastric mucosal injury.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Endothelins; Gastric Mucosa; Gastrointestinal H | 1991 |
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.
Topics: Allopurinol; Animals; Catalase; Chromium Radioisotopes; Deferoxamine; Free Radical Scavengers; Free | 1991 |
BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat.
Topics: Adrenalectomy; Animals; Anti-Ulcer Agents; Benzimidazoles; Cimetidine; Corticosterone; Cysteamine; D | 1991 |
Solcoseryl in prevention of stress-induced gastric lesions and healing of chronic ulcers.
Topics: Actihaemyl; Analysis of Variance; Animals; Dinoprostone; Eflornithine; Epidermal Growth Factor; Gast | 1991 |
Lack of vitamin E cytoprotective effects on indomethacin-induced gastric lesions.
Topics: Animals; Duodenum; Gastric Mucosa; Indomethacin; Liver; Male; Oxidation-Reduction; Random Allocation | 1991 |
Gastric and jejunal ultrastructure in capsaicin-treated rats with and without experimental ulcer.
Topics: Animals; Capsaicin; Denervation; Ethanol; Gastric Mucosa; Indomethacin; Jejunum; Male; Microscopy, E | 1991 |
Gastric mucosal protection by sucralfate involves phosphoinositides participation.
Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; M | 1990 |
Effects of the new H2-receptor antagonist 3-amino-4-[4- [4- (1-piperidinomethyl)-2-pyridyloxy]-cis-2-butenylamino]-3-cyclobutene-1, 2- dione hydrochloride on gastric acid secretion and ulceration.
Topics: Animals; Anti-Ulcer Agents; Cold Temperature; Cysteamine; Duodenal Ulcer; Gastric Acid; Histamine; H | 1990 |
Possible prostaglandin-dopamine interactions during experimental gastric ulcer formation.
Topics: Animals; Apomorphine; Bromocriptine; Dopamine; Dopamine Agents; Dopamine Antagonists; Dose-Response | 1990 |
Role of leukotriene C4 in mucosal damage caused by necrotizing agents and indomethacin in the rat stomach.
Topics: Animals; Arachidonate 5-Lipoxygenase; Dinoprostone; Ethanol; Gastric Mucosa; Indoles; Indomethacin; | 1991 |
Effect of indomethacin on opioid-induced gastric protection in cold-restrained stress.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Gastric Mucosa; Indomethacin; Injections, Intraperi | 1991 |
Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Animals; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Omeprazole; Rats; | 1991 |
Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d,l-lactide) and poly(isobutyl-cyanoacrylate) nanocapsules in rats.
Topics: Animals; Capsules; Chemical Phenomena; Chemistry, Physical; Cyanoacrylates; Enbucrilate; In Vitro Te | 1991 |
[Cell kinetic study on the healing process of indomethacin-induced gastric mucosal lesion of rats].
Topics: Animals; Cell Cycle; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; S Phase; Stomac | 1991 |
Antisecretory and anti-ulcer effects of morphine in rats after gastric mucosal aggression.
Topics: Animals; Aspirin; Depression, Chemical; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Morphine; | 1991 |
Interleukin-1 inhibits stress-induced gastric erosion in rats.
Topics: Animals; Indomethacin; Injections, Intravenous; Injections, Intraventricular; Interleukin-1; Male; R | 1991 |
Protection by copper (II) complexes in various models of ulceration in rat.
Topics: Animals; Anti-Ulcer Agents; Copper; Gastric Acid; Hydrochloric Acid; Indomethacin; Male; Rats; Rats, | 1991 |
The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dogs; Female; Indomethacin; Male; Mice | 1991 |
Relationship between gastric mucosal prostaglandin levels and healing of gastric lesions in rats.
Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Male; Prostaglandins; Rats; Rats, Inbred Strains; St | 1990 |
Protective effect of propranolol on ethanol-induced gastric lesions in mice.
Topics: Administration, Oral; Animals; Ethanol; Gastrointestinal Hemorrhage; Indomethacin; Injections, Intra | 1990 |
Effects of a crude extract of a marine dinoflagellate, containing dimethyl-beta-propiothetin, on HCl.ethanol-induced gastric lesions and gastric secretion in rats.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Eukaryota; Gastric Mucosa; Hy | 1990 |
Research on heterocyclic compounds. XXVII. Synthesis and antiinflammatory activity of 2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Edema; Female; Human | 1990 |
Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat.
Topics: Animals; Arginine; Blood Pressure; Capsaicin; Epoprostenol; Gastric Mucosa; Indomethacin; Male; Neur | 1990 |
Role of arachidonic acid metabolites in acute gastric lesions induced by indomethacin in rats.
Topics: Animals; Arachidonic Acids; Dinoprostone; Epoprostenol; Gastric Mucosa; Indomethacin; Rats; Stomach | 1990 |
The gastroprotective effect of CHINOIN-127 on indomethacin induced gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Epoprostenol; Indomethacin; Prostaglandin-Endoperoxide Synthases; Pyrimi | 1990 |
Endogenous prostaglandins: its role in gastric mucosal blood flow and ethanol ulceration in rats.
Topics: Alprostadil; Animals; Blood Flow Velocity; Ethanol; Gastric Mucosa; Indomethacin; Male; Misoprostol; | 1990 |
Pharmacological profile of SK&F 105809, a dual inhibitor of arachidonic acid metabolism.
Topics: Administration, Oral; Analgesics; Animals; Arachidonic Acid; Arachidonic Acids; Arthritis, Experimen | 1990 |
Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process.
Topics: Animals; Immune Sera; Indomethacin; Leukotriene B4; Male; Methotrexate; Muscle, Smooth; Neutropenia; | 1990 |
Effect of captopril on oxyphenbutazone and ethanol-induced gastric lesions in rats.
Topics: Animals; Captopril; Ethanol; Indomethacin; Male; Oxyphenbutazone; Rats; Rats, Inbred Strains; Stomac | 1990 |
Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Animals; Drug Therapy, Combination; Gastric Acid; Histamine; Indomethacin; Ma | 1990 |
[Effect of dry ginger and roasted ginger on experimental gastric ulcers in rats].
Topics: Acetates; Animals; Drugs, Chinese Herbal; Female; Hot Temperature; Indomethacin; Male; Mice; Rats; R | 1990 |
Reduction of the severity of experimental gastric and duodenal ulceration by interleukin-1 beta.
Topics: Animals; Cysteamine; Duodenal Ulcer; Ethanol; Indomethacin; Injections, Intraperitoneal; Interleukin | 1990 |
Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Epidermal Growth Factor; Gastric Acid; Gastric Fistula; Histam | 1990 |
Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Ulcer Agents; Carnosine; Dinoprostone; Dipeptides; Eth | 1990 |
Mucosal protective activity of activated aluminum complex.
Topics: Aluminum Hydroxide; Animals; Antacids; Aspirin; Cysteamine; Duodenal Ulcer; Ethanol; Gastric Mucosa; | 1990 |
Effects of liver extract from the ocean sunfish (Mola mola) on acute gastric lesions in the rat.
Topics: Animals; Cimetidine; Hydrochloric Acid; Indomethacin; Liver Extracts; Male; Perciformes; Rats; Rats, | 1990 |
The use of a thymidine incorporation assay in the evaluation of the healing process following ethanol or indomethacin-induced gastric damage in rats.
Topics: Animals; DNA; Ethanol; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; Stomach Ulcer | 1990 |
Gastric antiulcer and cytoprotective effects of dipyridamole in rats.
Topics: Animals; Dipyridamole; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strai | 1990 |
Gastroprotective effect of meclofenamic acid on indomethacin-induced ulceration in rats.
Topics: Animals; Gastric Mucosa; Indomethacin; Meclofenamic Acid; ortho-Aminobenzoates; Rats; SRS-A; Stomach | 1990 |
Possible mechanisms involved in gastric hypermotility caused by indomethacin in the rat. Role of glycoprivic response.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Blood Glucose; Dose-Response Relationship, Drug; Drug Inter | 1990 |
The effect of long-term prostacyclin treatment on the protein, DNA and RNA content of rat gastric fundic mucosa.
Topics: Animals; DNA; Epoprostenol; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Proteins; Rats; Ra | 1985 |
Gastric antral and fundic mucosal protein, DNA and RNA changes in different experimental ulcer models.
Topics: Animals; Disease Models, Animal; DNA; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Proteins | 1985 |
Protective effect of iloprost and UK 38 485 against gastric mucosal damage induced by various stimuli.
Topics: Animals; Epoprostenol; Ethanol; Female; Gastric Mucosa; Iloprost; Imidazoles; Indomethacin; Male; Ra | 1987 |
Cardiopulmonary and gastric ulcerogenic actions of endothelin-1 in the guinea pig and rat.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Endothelins; Gastric Mucosa; Guinea Pigs; Heart Rat | 1989 |
Microscopic correlates of adaptive cytoprotection in an ethanol injury model.
Topics: Animals; Ethanol; Female; Gastric Mucosa; Indomethacin; Irritants; Rats; Rats, Inbred Strains; Stoma | 1989 |
Gastric antisecretory and antiulcer/cytoprotective effects of 2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester.
Topics: Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cyanoacrylates; Ethanol; | 1989 |
The effect of prostacyclin treatment on the changes of cyclic nucleotide levels of rat antral and fundic gastric mucosa in different experimental ulcer models.
Topics: Animals; Cyclic AMP; Cyclic GMP; Epoprostenol; Gastric Fundus; Gastric Mucosa; Indomethacin; Pyloric | 1989 |
Effect of epidermal growth factor on non-steroidal anti-inflammatory drug-induced intestinal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dimaprit; Epidermal Growth Factor; Ethanol; Gastri | 1989 |
Gastroprotective activity of ginger zingiber officinale rosc., in albino rats.
Topics: Animals; Aspirin; Drugs, Chinese Herbal; Ethanol; Female; Hydrochloric Acid; Indomethacin; Male; Rat | 1989 |
Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Animals; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gastric A | 1989 |
Effects of ALE-36 on gastric secretion, and gastric and duodenal ulcers induced in rats.
Topics: Animals; Benzimidazoles; Chlorides; Dose-Response Relationship, Drug; Duodenal Ulcer; Gastric Juice; | 1989 |
The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats.
Topics: Animals; Biomechanical Phenomena; Gastric Mucosa; Indomethacin; Male; Omeprazole; Prostaglandin D2; | 1989 |
[The role of sulfhydryls in indomethacin-induced gastric mucosal injury in rats].
Topics: Animals; Cysteamine; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; S | 1989 |
Comparative antiulcer and antisecretory effects of various calcium antagonists.
Topics: Animals; Anti-Ulcer Agents; Calcium Channel Blockers; Ethanol; Gastric Acid; Gastric Mucosa; Indicat | 1989 |
Circadian rhythms of food intake in gastroduodenally-ulcerated rats: effects of three anti-ulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Circadian Rhythm; Duodenal Ulcer; Eating; Female; Indomethacin; Male; Pi | 1989 |
Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach.
Topics: Animals; Blood Pressure; Diterpenes; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vas | 1989 |
Up-regulation of prostaglandin E2 binding and of prostanoid release in rabbits producing antibodies against prostaglandin E2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antibody Formation; Arachidonic Acids; Dinoprostone; Epoprost | 1989 |
Neomycin prevents indomethacin-induced gastric peristalsis and mucosal injury in the rat.
Topics: Animals; Bacitracin; Blood Glucose; Female; Gastric Mucosa; Gastrointestinal Motility; Indomethacin; | 1989 |
Influence of indomethacin amphoteric gel on gastric ulcerogenicity and absorption of indomethacin in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressur | 1989 |
Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.
Topics: Animals; Antioxidants; Azoles; Ethanol; Gastric Mucosa; Indomethacin; Isoindoles; Male; Necrosis; Or | 1989 |
Effects of NC-1300, a gastric proton pump inhibitor, on healing of acetic acid-induced gastric ulcers in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Administration, Oral; Animals; Anti-Ulcer Agents; | 1989 |
Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat. Role of enhanced gastric motility.
Topics: Adrenalectomy; Animals; Blood Glucose; Gastric Acid; Gastric Mucosa; Gastrointestinal Motility; Gluc | 1989 |
Lipid peroxidation in normal and ulcerated gastric mucosa of rats treated with pentacaine and cimetidine.
Topics: Animals; Carbamates; Cimetidine; Ethanol; Gastric Mucosa; Indomethacin; Lipid Peroxidation; Male; Ma | 1989 |
Effects of fish oil on gastric mucosal 6-keto-PGF1 alpha synthesis and ethanol-induced injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Ethanol; Female; Fish Oils; Gastric Mucosa; Indomethacin; Rat | 1989 |
Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Epirizole; Ethanol; Gastric Acid; Gastric Mucosa; Imm | 1989 |
Cytoprotective and antiulcer activities of the antacid magaldrate in the rat.
Topics: Aluminum Hydroxide; Animals; Antacids; Anti-Ulcer Agents; Aspirin; Cell Survival; Cysteamine; Dinopr | 1989 |
The pharmacological profile of CGP 28238, a highly potent anti-inflammatory compound.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Gastrointestinal H | 1989 |
Effect of parathyroid hormone, centrally or peripherally injected, on gastric activity in male rats.
Topics: Animals; Ethanol; Gastric Acid; Indomethacin; Injections, Intravenous; Injections, Intraventricular; | 1989 |
Reduction of indomethacin induced gastroduodenal mucosal injury and gastrointestinal symptoms with cimetidine in normal subjects.
Topics: Adolescent; Adult; Cimetidine; Digestive System; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; H | 1989 |
A possible mechanism for the gastric mucosal protection by oren-gedoku-to (OGT), a traditional herbal medicine.
Topics: Animals; Anti-Ulcer Agents; Drugs, Chinese Herbal; Ethanol; Ethylmaleimide; Glutathione; Indomethaci | 1989 |
Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors.
Topics: Animals; Anticonvulsants; Atropine; beta-Alanine; Bicuculline; Drug Synergism; gamma-Aminobutyric Ac | 1988 |
Effects of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)-acetoxyacetamide hydrochloride (TZU-0460), a histamine H2-receptor antagonist, on gastric acid secretion and ulcer formation.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Cysteamine; Dogs; Gastric Acid; Histamine; Histamine | 1985 |
Cytoprotective action of carbenoxolone sodium on ethanol-induced gastric lesions in rats and its inhibition by indomethacin.
Topics: Animals; Carbenoxolone; Ethanol; Glycyrrhetinic Acid; Indomethacin; Male; Rats; Rats, Inbred Strains | 1985 |
Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Duodenal Ulcer; Female; Humans; Ibuprofen; Indome | 1986 |
Sulphasalazine and experimental stress ulcers.
Topics: Administration, Oral; Animals; Dinoprostone; Female; Indomethacin; Injections, Subcutaneous; Prostag | 1985 |
Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Clonidine; Cysteamine; Di | 1987 |
The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats.
Topics: Animals; Anti-Ulcer Agents; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Female; Gastri | 1988 |
Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin.
Topics: Acetates; Acetic Acid; Animals; Dinoprostone; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Rats | 1989 |
The mechanism of acute gastric ulcer after induced hemorrhagic shock.
Topics: Acute Disease; Animals; Blood Pressure; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Norepineph | 1989 |
Gastric anti-ulcer and cytoprotective effect of selenium in rats.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Dimaprit; Ethanol; Female; Gastric Acid; Gastric | 1988 |
Comparison of the ulcerogenicity of indomethacin and the gastric secretion in verapamil-treated rats.
Topics: Animals; Dose-Response Relationship, Drug; Gastric Juice; Gastric Mucosa; Hydrochloric Acid; Hydroge | 1988 |
Changes of cAMP and cGMP levels of rat antral and fundic gastric mucosa in different ulcer models.
Topics: Animals; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Female; Gastric Fundus; Gastric Mucosa; Ind | 1987 |
Relative roles of acid and mucosal compression in ulcerogenesis in indomethacin-insulin-treated rat.
Topics: Animals; Cimetidine; Female; Gastric Acid; Gastrointestinal Motility; Indomethacin; Insulin; Rats; S | 1988 |
[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidoni | 1986 |
Protection by mild irritants against indomethacin-induced gastric mucosal damage in the rat: role of prostaglandin synthesis.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Animals; Dinoprostone; Ethanol; Gastric Acid; Gastric M | 1986 |
Cytoprotective action of mast cell stabilizers against ethanol-induced gastric lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Bicarbonates; Chromones; Cromolyn Sodium; Ethanol; Gastric Acid; Gastric | 1986 |
Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 2nd communication: inhibitory effects on acute inflammation and prostaglandin-related reactions.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Benzopyrans; Benzothiepins; | 1986 |
[Study on the effect of oxygenation under high pressure (OHP) on the rat gastric mucosa].
Topics: Animals; Gastric Mucosa; Hyperbaric Oxygenation; Indomethacin; Male; Pepsin A; Rats; Rats, Inbred St | 1987 |
[Protection by acupuncture on gastric mucosal damage in rats].
Topics: Acupuncture Therapy; Animals; Electric Stimulation Therapy; Female; Gastric Mucosa; Indomethacin; Ma | 1987 |
Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: effects on gastric acid secretion and stress-induced mucosal damage.
Topics: Animals; Diet; Dinoprostone; Female; Fistula; Gastric Juice; Gastric Mucosa; Indomethacin; Ligation; | 1988 |
Indomethacin-induced gastric antral ulcers in hamsters.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal | 1988 |
Is the gastric lesion correlated with the inhibition of tissular peroxidase activity induced by indomethacin?
Topics: Animals; Gastric Mucosa; Indomethacin; Kinetics; Neutrophils; Parietal Cells, Gastric; Peroxidases; | 1988 |
Further studies on the role of the adrenals in the capsaicin-sensitive "gastric defence mechanism".
Topics: Adrenal Glands; Animals; Aspirin; Capsaicin; Drug Synergism; Ethanol; Indomethacin; Rats; Rats, Inbr | 1988 |
[Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Indomethacin; M | 1988 |
Analgesic profile of rimazolium as compared to different classes of pain killers.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cats; Dogs; Drug Toleranc | 1988 |
Relationship between the gastric myoelectric and mechanical activity in the genesis of ulcers in indomethacin-insulin-treated rats.
Topics: Animals; Blood Glucose; Cats; Electromyography; Female; Indomethacin; Insulin; Peristalsis; Rats; Ra | 1988 |
Gastric mucosal calmodulin changes in different experimental ulcer models of rat.
Topics: Animals; Calmodulin; Epoprostenol; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Kinetics; P | 1987 |
Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Atropine; Bicarbonates; Cimetidine; Gastric Acid; Gastric M | 1988 |
Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Administration, Oral; Animals; Biological Availability; Freeze F | 1988 |
Gastric anti-ulcer and cytoprotective effect of vitamin E in rats.
Topics: Animals; Anti-Ulcer Agents; Cell Survival; Cold Temperature; Female; Gastric Mucosa; Indomethacin; M | 1988 |
Indomethacin potentiates endotoxin-induced blood flow reduction and histological injury in rat gastric mucosa.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Gastric Mucos | 1988 |
Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Autoradiography; Body Weight; Gastric Mucosa; Gastrins; Ind | 1988 |
Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Indomethacin; In | 1988 |
Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats.
Topics: Animals; Drug Synergism; Female; Indomethacin; Male; Morphine; Rats; Rats, Inbred Strains; Stomach U | 1987 |
Effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl)phenyl] propionic acid hydrochloride on gastric mucosa directly from the lumen.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Autoradiography; Gastric Mucosa; Indomethacin; Inf | 1987 |
[Effect of intracerebroventricular injection of bombesin on indomethacin-induced gastric ulcer in rats].
Topics: Animals; Bombesin; Indomethacin; Injections, Intraventricular; Male; Rats; Stomach Ulcer; Thalamus | 1987 |
Oxygen free radicals interact with indomethacin to cause gastrointestinal injury.
Topics: Animals; Anti-Inflammatory Agents; Butylated Hydroxytoluene; Digestive System; Dinoprostone; Ethanol | 1986 |
Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprostone; Gastric Mucosa; Gastrointestinal Motility; Indo | 1986 |
Synthesis of prostaglandin E2, thromboxane B2 and prostaglandin catabolism in gastritis and gastric ulcer.
Topics: Dinoprostone; Female; Gastric Mucosa; Gastritis; Humans; Indomethacin; Male; Prostaglandin Antagonis | 1986 |
Further evidence for gastroprotection induced by aluminium hydroxide in the rat.
Topics: Aluminum Hydroxide; Animals; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Prostaglandi | 1986 |
Gastric mucosal protection by agents altering gastric mucosal sulfhydryls. Role of endogenous prostaglandins.
Topics: Animals; Anti-Ulcer Agents; Cysteamine; Dinoprostone; Female; Gastric Mucosa; Indomethacin; Male; Ma | 1987 |
Role of mucus and prostaglandins in the gastric mucosal protective actions of sucralfate against ethanol-induced injury in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Mu | 1987 |
Gastric mucosa protective effects of colloidal bismuth subcitrate (DE-NOL).
Topics: Animals; Anti-Ulcer Agents; Dinoprostone; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Organ | 1987 |
Antiulcer activity of clonidine: lack of effect on gastric prostaglandins.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Clonidine; Dinoprostone; Female; Gastric Mucosa; Indomethacin | 1987 |
Pharmacological activity of FPP028 (2-phenylpyrazolo-4-ethyl-4,7-dihydro [1,5a]pyrimidin-7-one) a new non-steroid anti-inflammatory agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1986 |
Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1987 |
Pharmacological properties of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal antiinflammatory agent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Fever; Indomethacin; Inflammation; Pain; Piroxicam | 1987 |
Pharmacological activity of some pyrrolo and pyrazolo pyrimidine derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Humans; In Vitro Techniques; I | 1987 |
Comparative effects of indomethacin and proglumetacin on 6-oxo-PGF1 alpha released ex vivo by rat gastric mucosa.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Epoprostenol; Gastric Mucosa; Indoleacetic Acids; Indomethaci | 1986 |
Eicosanoids and the gastrointestinal tract: promising but no verdict yet.
Topics: Biliary Tract Diseases; Colitis, Ulcerative; Digestive System; Eicosanoic Acids; Epoprostenol; Human | 1986 |
Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons.
Topics: Animals; Capsaicin; Cysteamine; Dinoprostone; Duodenal Ulcer; Epoprostenol; Ethanol; Female; Gastric | 1986 |
Interaction between prostacyclin and colchicine on the gastric mucosa of rat in different experimental ulcer models.
Topics: Animals; Colchicine; Drug Interactions; Epoprostenol; Female; Gastric Mucosa; Indomethacin; Rats; Ra | 1986 |
Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats.
Topics: Animals; Cell Survival; Cimetidine; Cysteamine; Duodenal Ulcer; Female; Gastric Acid; Gastric Mucosa | 1987 |
The effects of the stable thromboxane A2-mimetic, U46619, on gastric mucosal damage and gastric non-parietal secretion in the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Ulcer Agents; Biph | 1987 |
Effects of morphine and met-enkephalin analogue on gastric lesions induced by indomethacin.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Indomethacin; Male; Morphine; Rats; Rats, Inbred St | 1987 |
Efficacy of sucralfate in preventing peptic ulceration induced by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Indomethacin; Male; Peptic Ulcer; Rats; S | 1987 |
Studies on the gastroulcerogenic effects of pylorus ligation, hypothermic restraint stress, aspirin, indomethacin and reserpine in morphine dependent rats.
Topics: Animals; Aspirin; Gastric Acid; Hypothermia; Indomethacin; Ligation; Male; Morphine Dependence; Pylo | 1987 |
Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Dose-Response Relationship, Drug; Drug Interactions; Duoden | 1987 |
Milk protection against experimental ulcerogenesis in rats.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Cholestyramine Resin; Disease Models, Animal; Gast | 1987 |
Influence of peripherally-administered peptides on ethanol-induced gastric ulcers in the rat.
Topics: Animals; Ethanol; Indomethacin; Injections, Subcutaneous; Male; Peptides; Rats; Rats, Inbred Strains | 1987 |
Evidence of "cross-stressor"-induced adaptive gastric cytoprotection.
Topics: Adaptation, Physiological; Animals; Cold Temperature; Ethanol; Gastric Mucosa; Indomethacin; Male; R | 1987 |
Effects of indomethacin and cold-stress on gastric acid secretion and ulceration. The effects of anti-acid secretory agents in rats.
Topics: Animals; Anti-Ulcer Agents; Cold Temperature; Gastric Acid; Indomethacin; Ligation; Male; Pylorus; R | 1987 |
[Studies of superoxide dismutase in rat gastric mucosal damage (2d report)--Pathogenesis of indomethacin-induced gastric ulcer].
Topics: Animals; Gastric Mucosa; Indomethacin; Male; Rats; Stomach Ulcer; Superoxide Dismutase | 1987 |
Gastrointestinal studies of Pyrenacantha staudtii leaf extracts.
Topics: Animals; Anti-Ulcer Agents; Chemical Phenomena; Chemistry; Cold Temperature; Dose-Response Relations | 1986 |
Evidence for a role of adrenals in the capsaicin-sensitive "gastric defence mechanism" in rats.
Topics: Adrenal Glands; Adrenalectomy; Animals; Capsaicin; Indomethacin; Male; Rats; Rats, Inbred Strains; S | 1986 |
Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Chalcone; Chalcones; Ethanol; Female; Gastric Juice; Indomethac | 1986 |
Protection by metals against ethanol-induced gastric mucosal injury in the rat. Comparative biochemical and pharmacologic studies implicate protein sulfhydryls.
Topics: Animals; Cadmium; Copper; Ethanol; Ethylmaleimide; Female; Gastric Acid; Gastric Mucosa; Indomethaci | 1986 |
Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin.
Topics: Animals; Cysteamine; Disease Models, Animal; Drug Synergism; Duodenal Ulcer; Epirizole; Histamine; I | 1986 |
Gastric anti-ulcer and cytoprotective properties of 2-(3,4-dimethoxyphenyl)-5-methyl-thiazolidine-4-one in rat experimental ulcers.
Topics: Acetates; Animals; Anti-Ulcer Agents; Cell Survival; Cimetidine; Ethanol; Gastric Mucosa; Indomethac | 1986 |
Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa.
Topics: Animals; Diterpenes; Epithelium; Ethanol; Gastric Mucosa; Indomethacin; Male; Membrane Potentials; M | 1986 |
Ulcerogenic and antiulcerogenic effects of a new antiinflammatory drug, the gamma-lactone-N-ethyl derivative of 6-[1S-(3S,4-dihydro-8-hydroxy-1H-2-benzo- pyran-1-one-3-yl)-3-methylbutylamino]-4S,5S-dihydroxy-6-oxo-3S- ammoniohexanoate, on gastrointestinal
Topics: Animals; Anti-Ulcer Agents; Aspirin; Coumarins; Gastrointestinal Motility; Indomethacin; Isocoumarin | 1986 |
Cytoprotective effects of NC-1300 and omeprazole on Hcl . ethanol-induced gastric lesions in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Ethanol; Ethylm | 1986 |
Protection by sucralfate against indomethacin induced gastric ulceration in the guinea pig.
Topics: Aluminum; Animals; Guinea Pigs; Indomethacin; Membrane Potentials; Permeability; Stomach Ulcer; Sucr | 1985 |
[Influence of oleic acid on gastric mucus secretion in indomethacin-induced gastric mucosal lesions in rats].
Topics: Animals; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Indomethacin; Male; Mucus; Oleic | 1985 |
Cytoprotective effect of sofalcone in the rat gastric mucosa.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Carbenoxolone; Chalcone; Chalcones; Cimetidine; Di | 1985 |
Fatal antral ulcer in conventionally fed W/Wv mutant mice given indomethacin by injection.
Topics: Animals; Aspirin; Dinoprostone; Disease Susceptibility; Fasting; Gastric Mucosa; Indomethacin; Injec | 1985 |
Gastric mucosal protection by spizofurone.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Dinoprostone; Electrolytes; Ethanol; Gastric Mucos | 1985 |
Effects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosa.
Topics: Animals; Dinoprostone; Ethanol; Gastric Mucosa; Histamine; Indomethacin; Male; Prostaglandins E; Rat | 1985 |
Ulcer formation and cytoprotection by acetazolamide.
Topics: 16,16-Dimethylprostaglandin E2; Acetazolamide; Animals; Aspirin; Dinoprostone; Ethanol; Female; Gast | 1985 |
Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103).
Topics: Acetates; Acetic Acid; Aminopyrine; Animals; Anti-Ulcer Agents; Aspirin; Bethanechol Compounds; Cime | 1985 |
Analysis of the analgesic and anti-inflammatory effects of rimazolium, a pyrido-pyrimidine derivative, compared with that of prostaglandin synthesis inhibitors and morphine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Indomethacin; Leukocytes; Luminescent Meas | 1985 |
Possible involvement of non-steroidal anti-inflammatory drugs in vagal-mediated gastric acid secretion in rats.
Topics: Animals; Anti-Inflammatory Agents; Deoxyglucose; Dinoprostone; Gastric Acid; Histamine; Humans; Imme | 1985 |
Salicylic acid blocks indomethacin-induced cyclooxygenase inhibition and lesion formation in rat gastric mucosa.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Gastric Mucosa; Humans; Indomethacin; | 1985 |
[Effects of 2-benzyloxycarbonylphenyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride monohydrate (TKG01) and its clathrate compound with beta-cyclodextrin (TA903) on experimental gastric ulcers and gastric secretion in rats].
Topics: Animals; Anti-Ulcer Agents; beta-Cyclodextrins; Cyclodextrins; Cyclohexanecarboxylic Acids; Dextrins | 1985 |
Structural damage and changes in eicosanoid metabolites in the gastric mucosa of rats and pigs induced by anti-inflammatory drugs of varying ulcerogenicity.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Diflunisal; Gastric Mucosa; Indomethacin; Membrane Poten | 1986 |
Comparison of inhibitory effects of atropine, cimetidine, and atropine plus cimetidine on the indomethacin-provoked gastric mucosal erosions in rats.
Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Synergism; | 1986 |
Prolactin inhibits the development of stress-induced ulcers in the rat.
Topics: Animals; Domperidone; Haloperidol; Indomethacin; Kidney; Male; Pituitary Gland, Anterior; Prolactin; | 1985 |
Morphine potentiates the gastroulcerogenic effect of indometacin in rats.
Topics: Animals; Atropine; Cimetidine; Drug Synergism; Female; Gastric Mucosa; Indomethacin; Male; Morphine; | 1985 |
Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat.
Topics: Animals; Body Weight; Eating; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Intestinal Disea | 1985 |
Incidence of gastric ulcers by indomethacin and piroxicam in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Indomethacin; Male; Piroxicam; Rats; Rats, Inbred | 1985 |
Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Eating; Female; Indomethacin; Intestinal Disease | 1985 |
Influence of antioxidants and radical scavengers on ethanol-induced gastric ulcers in the rat.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Benzoates; Benzoic Acid; Cimetidine; Ethanol; Free Radical | 1985 |
Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms.
Topics: Acetaminophen; Alcohol Drinking; Analgesics; Anti-Inflammatory Agents; Aspirin; Chronic Disease; Fem | 1985 |
Experimental anti-ulcer activity of Veronica officinalis L. extracts.
Topics: Animals; Anti-Ulcer Agents; Indomethacin; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbre | 1985 |
Gastric antral ulcers induced by a combination of acid, indomethacin and ischemia in rats.
Topics: Animals; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Ischemia; Male; Pyloric Antrum; Rats; Rats | 1985 |
Gastrointestinal effects of the extracts of Rhigiocarya racemifera (Menispermaceae).
Topics: Animals; Cimetidine; Female; Gastrointestinal Diseases; Glycosides; Indomethacin; Ligation; Male; Mi | 1985 |
Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats.
Topics: Animals; Carrageenan; Edema; Female; Indomethacin; Lipid Peroxides; Rats; Stomach Ulcer; Time Factor | 1985 |
Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers.
Topics: Acetates; Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Chronic Dise | 1985 |
Effects of intracerebroventricular bombesin on gastric ulcers and gastric glycoproteins in rats.
Topics: Animals; Aspirin; Bombesin; Chromatography, Gel; Gastric Acid; Gastric Mucosa; Glycoproteins; Indome | 1985 |
The effect of D-penicillamine in different experimental gastric ulcer models in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Female; Indomethacin; Penicillamine; Rats; Rats, Inbred S | 1985 |
[Gastroduodenal ulcer: pathogenetic and clinical aspects].
Topics: Alcoholic Beverages; Diet; Duodenal Ulcer; Gastric Juice; Gastrins; Gastrointestinal Hormones; Hista | 1974 |
Pharmacology of zolimidine (2-(p-methylsulfonylphenyl)-imidazo (1,2-a) pyridine) a new non-anticholinergic gastroprotective agent. II) Protective activity against drug-induced experimental ulcers.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Guinea Pigs; Histamine; Histamine H1 Antagon | 1974 |
Pharmacology of zolimidine (2-(p-methylsulfonylphenyl)-imidazo (1,2-a) pyridine) a new non-anticholinergic gastroprotective agent. IV) Enhancement of gastric mucus production in different experimental models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cold Temperature; Gastric Mucins; Gastric Mu | 1974 |
[Iatrogenic gastroduodenal ulcerations. Corticosteroids excluded].
Topics: Aged; Bone Neoplasms; Carcinoma, Squamous Cell; Cyclophosphamide; Duodenal Ulcer; Female; Humans; In | 1973 |
Anti-inflammatory drugs in rheumatic diseases.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Aspirin | 1974 |
Evaluation of the potential of gastric ulceration after administration of certain drugs.
Topics: Amines; Aminopyrine; Animals; Ascorbic Acid; Aspirin; Chlorpromazine; Cortisone; Desoxycorticosteron | 1967 |
Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids.
Topics: Administration, Oral; Animals; Depression, Chemical; Diarrhea; Fatty Acids, Unsaturated; Female; Gas | 1974 |
Prostaglandins VII: a proposed role for Pge2 in the genesis of stress-induced gastric ulcers.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Indomethacin; Injections, Subcutane | 1974 |
Species differences in susceptibility to the gastro-ulcerogenic action of anti-inflammatory agents.
Topics: Administration, Oral; Ambystoma; Animals; Anti-Inflammatory Agents; Cricetinae; Dose-Response Relati | 1974 |
Prevention by two anticholinergic drugs of indomethacin-induced gastric mucosal ulceration in rats.
Topics: Animals; Atropine; Female; Gastric Mucosa; Humans; Indomethacin; Male; Rats; Stomach Ulcer | 1974 |
Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.
Topics: Adrenal Glands; Adrenalectomy; Animals; Atropine; Cordotomy; Dose-Response Relationship, Drug; Femal | 1973 |
Gastric mucosal damage by anti-inflammatory drugs.
Topics: Absorption; Anti-Inflammatory Agents; Aspirin; Diffusion; Gastric Mucins; Gastric Mucosa; Gastritis; | 1972 |
Effects of the non-steroidal antiphlogistics on the gastric mucosal barrier and hexosamine content in rats.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biological Transport; Carboxylic Acids; Chlorine; Cycloh | 1972 |
[Ulcers of the gastroduodenal tract due to drugs. Apropos of a personal experience].
Topics: Adrenal Cortex Hormones; Adult; Aged; Analgesics; Aspirin; Duodenal Ulcer; Female; Gastrointestinal | 1972 |
[Gastro-duodenal tolerance of some drugs with analgesic effect. Clinico-endoscopic considerations].
Topics: Analgesics; Anti-Inflammatory Agents; Antimalarials; Aspirin; Digestive System; Duodenal Ulcer; Esop | 1974 |
Pharmacology of a new non-steroidal anti-inflammatory agent 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one (W-2395).
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Benzoxazi | 1974 |
Effect of L-glutamine on indomethacin-induced gastric lesions in the rat.
Topics: Animals; Glutamine; Indomethacin; Ligation; Male; Pylorus; Rats; Stomach Ulcer | 1974 |
Renal and gastric lesions after phenylbutazone and indomethacin in the rat.
Topics: Animals; Ascites; Epithelium; Female; Gastrointestinal Hemorrhage; Indomethacin; Kidney; Kidney Papi | 1974 |
[Gastric erosions and ulcerations in gastritis caused by drugs].
Topics: Aminopyrine; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastritis; Gastroscopy; Gluco | 1972 |
The Berry Lecture. Studies of the gastric mucosal barrier--its relevance to clinical gastric disease.
Topics: Animals; Aspirin; Dogs; Epithelium; Female; Gastric Mucins; Gastric Mucosa; Gastritis; Humans; Hydro | 1972 |
Prevention by disulfiram of restraint- and indomethacin-induced gastric mucosal ulceration in rats.
Topics: Animals; Cold Temperature; Disulfiram; Fasting; Female; Gastric Mucosa; Immobilization; Indomethacin | 1973 |
Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Aspirin; Biological Transport, Active; Cell Membrane Permeability; Chl | 1974 |
[Significance of the gastric mucus as a mucosa-protection].
Topics: Cortisone; Gastric Juice; Gastric Mucosa; Glycoproteins; Humans; Indomethacin; Phenylbutazone; Stoma | 1974 |
Upper gastrointestinal disease in rheumatoid arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Arizona; Arthritis, Rheumatoid; Aspir | 1974 |
Prevention of restraint and indomethacin-induced gastric ulceration by bile duct or pylorus ligation in rats.
Topics: Animals; Bile Acids and Salts; Bile Ducts; Disease Models, Animal; Female; Indomethacin; Ligation; M | 1974 |
[Blood levels and urinary excretion of zolimidine-indomethacin combination].
Topics: Animals; Drug Combinations; Female; Imidazoles; Indomethacin; Male; Pyridines; Rats; Stomach Ulcer | 1974 |
Multiple benign gastric ulcers. A clinical and gastroscopic study.
Topics: Adult; Aged; Alcohol Drinking; Gastroscopy; Humans; Indomethacin; Male; Middle Aged; Peptic Ulcer He | 1974 |
Gastric blood flow and its distribution during indomethacin administration.
Topics: Animals; Catheterization; Dogs; Duodenum; Esophagus; Indomethacin; Melena; Radioisotope Dilution Tec | 1970 |
The effects of anti-ulcer agents on indomethacin-induced gastric ulceration in the rat.
Topics: Analysis of Variance; Animals; Antacids; Drug Antagonism; Gastric Juice; Gastric Mucosa; Indomethaci | 1971 |
[Comparative study on the ulcerogenous effect of various antiphlogistic agents].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Female; Gastric Mucosa; Indomethacin; Prednisone; Rats; | 1971 |
The production of acute gastric ulceration by indomethacin in the rat.
Topics: Animals; Indomethacin; Injections, Intraperitoneal; Male; Methods; Rats; Stomach Ulcer; Time Factors | 1969 |
Gastric ulcer and the anti-arthritic drugs.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Indomethacin; Male; Middle Aged; Peptic Ulcer He | 1971 |
Indomethacin. Effect on gastric secretion, parietal cell population, and ulcer provocation in the dog.
Topics: Animals; Dogs; Gastric Juice; Gastric Mucosa; Indomethacin; Peptic Ulcer Hemorrhage; Peptic Ulcer Pe | 1968 |
Gastric ulceration occurring during indomethacin therapy.
Topics: Adult; Aged; Anemia; Dyspepsia; Female; Humans; Indomethacin; Male; Middle Aged; Pylorus; Radiograph | 1968 |
[Use of antiphlogistics for athletic injuries].
Topics: Analgesics; Athletic Injuries; Central Nervous System Diseases; Humans; Indomethacin; Male; Oxyphenb | 1969 |
[Pharmacological and toxicological testing of new anti-inflammatory agent azapropazon=3-dimethylamine-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine].
Topics: Abnormalities, Drug-Induced; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bloo | 1969 |
Indomethacin and gastric ulcer.
Topics: Humans; Indomethacin; Stomach Ulcer | 1965 |
[Efficacy of indomethacin treatment].
Topics: Aged; Female; Humans; Indomethacin; Stomach Ulcer | 1965 |