Page last updated: 2024-10-29

indomethacin and Stomach Ulcer

indomethacin has been researched along with Stomach Ulcer in 1200 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Research Excerpts

ExcerptRelevanceReference
"Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration."9.08Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. ( Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G, 1997)
"In the present study, we investigated the gastroprotective potential of HQJZT in a rat model of indomethacin (IND)-induced gastric ulcer and explained the biochemical, cellular, and molecular mechanisms involved."8.84Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms. ( Cai, X; Gao, Q; Lu, J; Ou, C; Peng, Q; Ren, B; Song, H; Wang, X; Xiong, M; Yu, C; Zeng, M; Zhong, M; Zhou, S, 2024)
"Unlike quercetin, chlorogenic acid could not prevent gastric ulcers in indomethacin-treated rats."8.31Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration. ( Angkhasirisap, W; Boonyong, C; Jianmongkol, S; Kengkoom, K, 2023)
" The present work aimed to annotate the secondary metabolites from a butanol fraction of apple leaves (BLE), evaluate the gastro-protective and healing effects of this fraction against indomethacin-induced gastric ulcers in rats and to identify its mechanism of action."8.31Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats. ( Abdelfattah, MAO; Abdo, W; Drissi, B; El-Shazly, AM; Mahmoud, MF; Nabil, M; Sobeh, M, 2023)
"The aim of this study was to investigate the potential protective effects of walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats."8.31The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats. ( Hao, Y; Kang, J; Li, Y; Liu, R; Liu, X; Mao, R; Yu, X; Zhu, N, 2023)
"7 g/kg) or ranitidine (40 mg/kg) were orally administered in rats for three weeks before the induction of gastric ulcer using indomethacin (30 mg/kg, single oral dose)."8.31Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats. ( Bai, L; Bao, M; Bao, T; Chen, Y; Feng, L; Fu, M; Li, Y; Mu, X; Ta, N; Zhang, J, 2023)
"We used the murine re-fed indomethacin (IND) experimental ulcer model."8.31Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT ( Akiba, Y; Kaunitz, JD; Satoh, H; Urushidani, T, 2023)
"This experiment aimed to investigate the preventive effect of ethanol extract (RM) from Chinese sumac fruits on indomethacin-induced gastric ulcer in mice and the underlying mechanisms."8.12Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis. ( Cai, S; Ma, N; Sun, Y; Yi, J; Zhou, L, 2022)
"We investigated the potential gastroprotective effects of chrysin on indomethacin induced gastric ulcers in rats."8.12Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation. ( Kandemir, FM; Küçükler, S; Yıldırım, S, 2022)
"This study investigated the link between forced swim induced acute gastric ulceration, inflammation and MMP-3 along with the possible mechanism of protective efficacy of melatonin."8.12Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade. ( Chatterjee, A; Choudhary, P; Mishra, VK; Pant, S; Roy, T; Swarnakar, S, 2022)
"This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the mechanism behind this protective effect."8.12RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats. ( Bai, L; Bao, T; Chen, Y; Cho, S; Dai, L; Feng, L; Fu, M; Jin, W; Yu, H; Zhang, J, 2022)
" The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy."8.02Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021)
"Curcumin is claimed as a potent protectant against Gastric Ulcer (GU) induced by strong necrotizing agents, including NSAIDs through its antioxidant, anti-inflammatory and gastroprotective activities."8.02Efficacy of a Chitosan-curcumin Mixture in Treating Indomethacininduced Acute Gastric Ulcer in Rats. ( Kaewsuwan, S; Kuadkaew, S; Mahattanadul, S; Phdoongsombut, N; Ungphaiboon, S, 2021)
"This study aimed to investigate the gastroprotective effect of chlorogenic acid (CGA) against Indomethacin (IND)-induced gastric ulcer (GU) in rats and its underlying mechanism, especially through autophagic and apoptotic pathways."8.02Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling. ( Aboulhoda, BE; Ahmed, AAE; Ahmed, MAE; El-Awdan, SA; Mohanad, M, 2021)
" speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs."8.02Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021)
"The results of this study showed that agomelatine usage in indomethacin-induced gastric ulcer model provides beneficial results."7.96Agomelatine prevents indomethacin-induced gastric ulcer in rats. ( Eraslan, E; Güler, MC; Kurt, N; Tanyeli, A; Yetim, Z, 2020)
" This study investigated the involvement of oxidative stress in the healing and protective potentials of aqueous leave extract of Telfairia occidentalis (TO) on indomethacin induced gastric ulcers in adult Sprague Dawley male rats."7.96Attenuating Effect of Telfairia occidentalis on Oxidative Stress in Indomethacin-induced Gastric Ulcer in Male Rats. ( Adisa, W, 2020)
" Gastric ulcerated rats were administered AG, AG + dexamethasone, or pantoprazole after indomethacin exposure."7.91Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms. ( Abdallah, DM; El-Abhar, HS; El-Lekawy, AM, 2019)
" We monitored the intra- and extracellular redox status in the stomach of rats with indomethacin-induced gastric ulcers using OMRI and investigated the relationship with gastric mucosal damage."7.91In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging. ( Ichikawa, K; Kanbe, T; Mutsumoto, Y; Oda, F; Shigemi, R; Tun, X; Utsumi, H; Yamada, KI; Yasukawa, K, 2019)
"Safranal and lansoprazole normalized gastric volume and pH, reduced gastric ulcer area and produced gastric protection."7.91Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer. ( Erfanparast, A; Farshid, AA; Imani, M; Mirzakhani, N; Salighedar, R; Tamaddonfard, E; Tamaddonfard, S, 2019)
"The aim of this paper was to observe the combination therapy with total triterpenoids of Chaenomeles speciosa and omeprazole on indomethacin-induced gastric ulcer in rats, and explore its possible mechanism."7.91[Therapeutic effect of total triterpenoids of Chaenomeles speciosa combined with omeprazole on gastric ulcer induced by indomethacin in rats]. ( He, HB; He, YM; Li, XM; Li, XQ; Qin, HL; Wang, JZ; Xiong, XJ; Zhang, YF; Zou, K, 2019)
"The aim of the study was to investigate the effects of four Aronia melanocarpa-based juices in a rat model of indomethacin-induced gastric ulceration."7.91Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers. ( Denev, P; Eftimov, M; Georgieva, A; Kuzmanov, A; Kuzmanov, K; Kuzmanova, V; Tzaneva, M; Valcheva-Kuzmanova, S, 2019)
"The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats."7.88Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. ( Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H, 2018)
" One of its representative components, the tricyclic triterpenoid β-patchoulone (β-PAE) has demonstrated great anti-inflammatory activity and gastroprotective effect against ethanol-induced gastric injury, but its protective effect against gastric ulcer induced by indomethacin is still unknown."7.88Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. ( Chen, JN; Dou, YX; Huang, QH; Liang, JL; Liu, YH; Nie, J; Su, ZR; Wu, JZ; Wu, QD; Wu, X; Zhuo, JY, 2018)
" The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats."7.85Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats. ( Alkushi, AGR; Elsawy, NAM, 2017)
" After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days."7.85Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. ( Eyoum Bille, B; Kouitcheu Mabeku, LB; Nanfack Nana, B; Nguepi, E; Tchuenteu Tchuenguem, R, 2017)
"These findings suggest that ZnCl(2), enhances the gastroprotective activity ofrisperidone in indomethacin- induced gastric ulcer."7.83Zinc salt enhances gastroprotective activity of risperidone in indomethacin-induced gastric ulcer. ( Oluwole, FS; Onwuchekwa, C, 2016)
"The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats."7.83Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata. ( Garuba, T; Ismail, NO; Sabiu, S; Sulyman, AO; Sunmonu, TO, 2016)
"These results indicated that lycopene might have a protective effect against indomethacin-induced gastric ulcer and oxidative stress in rats."7.83The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats. ( Avci, H; Boyacioglu, M; Epikmen, ET; Karademir, U; Kum, C; Sekkin, S; Yalinkilinc, HS, 2016)
" The optimized GR formulation was examined for its protective effect on the gastric ulcer induced by indomethacin in albino rabbits compared with lactose tablets."7.83Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits. ( Abu Hashim, II; Badria, FA; Mohamed, EA; Yusif, RM, 2016)
" The aim was to scientifically evaluate the possible gastroprotective effect and the underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats."7.83The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. ( Chen, HM; Chen, XY; Fu, LD; Huang, XQ; Lai, XP; Liang, YZ; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Zhang, X; Zhang, ZB; Zheng, YF, 2016)
" In this study, we identified PA-rich food sources and examined the effects of the food materials on indomethacin-induced stomach ulcer."7.83Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer. ( Afroz, S; Ikoma, T; Kogure, K; Tanaka, T; Tokumura, A; Yagi, A, 2016)
"This study investigated the protective effects of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats."7.81Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats. ( Gomathy, G; Palani, S; Venkatesan, D, 2015)
" This study investigated the anti-ulcerogenic and antioxidant activities of aqueous extract of Carica papaya seed against indomethacin-induced peptic ulcer in male rats."7.81Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. ( Adaja, MC; Ajiboye, TO; Oloyede, HO; Salawu, MO, 2015)
" However, there is no report on the gastroprotective effect of ASB against indomethacin-induced gastric ulcer."7.81Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats. ( Chen, HM; Chen, XY; Feng, XX; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Yu, XT; Zeng, HF; Zhang, X; Zhang, ZB; Zheng, YF, 2015)
"The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats."7.80Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats. ( Agastian, P; Antonisamy, P; Balthazar, JD; Dhanasekaran, M; Duraipandiyan, V; Ignacimuthu, S; Kim, JH, 2014)
" In the present work, we evaluated the healing effect of L-theanine on NSAID (indomethacin)-induced gastric ulcer."7.80L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin. ( Bandyopadhyay, SK; Bera, B; Chatterjee, A; Chatterjee, S; Roy, S, 2014)
" This study investigated the possible mechanisms underlying the gastroprotective effect of escin against indomethacin-induced gastric ulcer in mice."7.80Protective effects of escin against indomethacin-induced gastric ulcer in mice. ( Chu, L; Du, H; Fu, F; Wang, T; Wang, Y; Yang, Y; Yao, L; Zhao, S, 2014)
"Gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg)."7.79Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats. ( El-Moselhy, MA; Morsy, MA, 2013)
"The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model."7.79Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice. ( Acharya, K; Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Khatua, S; Mukherjee, A; Mukherjee, S; Paloi, S, 2013)
"The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats."7.78Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. ( Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M, 2012)
"We examined the molecular mechanism of curcumin in a preventive and therapeutic model of indomethacin-induced gastric ulceration with regard to angiogenic processes."7.78Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling. ( Ganguly, K; Maulik, N; Paul, S; Sharma, AV; Swarnakar, S, 2012)
"The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP)."7.78Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity. ( Abdul Hisam, EE; Hasiah, AH; Norhafizah, M; Othman, F; Rofiee, MS; Vasudevan, M; Zakaria, ZA, 2012)
"This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer."7.78Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. ( Arcanjo Moura, B; Barbosa Filho, JM; de Almeida Leal, LK; de Barros Viana, GS; de Castro Brito, GA; dos Santos e Silva, G; Fragoso de Freitas, AP; Lopes Souto, A; Rios Vasconcelos, E; Santos Cerqueira, G; Silveira Macedo, D; Souccar, C, 2012)
"The mechanism of indomethacin-induced gastric ulcer healing by ellagic acid (EA) in experimental mice model is described in our study."7.78Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. ( Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A, 2012)
"The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats."7.78Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012)
" Hence, the potential of a new water-soluble GPx mimic, DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) in healing the indomethacin-induced stomach ulceration in mice was examined."7.78DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) accelerates healing of indomethacin-induced stomach ulceration in mice. ( Chakraborty, S; Chattopadhyay, S; Iwaoka, M; Priyadarsini, KI; Subramanian, M; Yadav, SK, 2012)
"9% for indomethacin-induced acute gastric ulcer (IAGU) rats, respectively] than those of ZAC alone due to the significantly slower renal clearance (CL(R))."7.77Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. ( Choi, YH; Kim, YG; Lee, M; Lee, MG; Lee, U; Oh, E; Suh, JH, 2011)
" Diabetes was induced in rats by a single dose of streptozotocin (STZ) followed by gastric ulceration using indomethacin, and melatonin's action was studied by its application prior to indomethacin exposure."7.77Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. ( Pradeepkumar Singh, L; Swarnakar, S; Vivek Sharma, A, 2011)
" Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice."7.77Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011)
"5]undecan-8-oxyl (compound 1) and 4-oxo-2,2,6,6-tetraethylpiperidine-1-oxyl (compound 2) in the prevention of gastric ulcers in adjuvant arthritis rats treated with indomethacin was evaluated by monitoring the reaction of reactive oxygen species in gastric tissue with Overhauser-enhanced magnetic resonance imaging (OMRI)."7.77Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats. ( Deguchi, H; Ichikawa, K; Kinoshita, Y; Mito, F; Naganuma, T; Sakai, K; Sato, S; Utsumi, H; Yamada, K; Yamasaki, T; Yamato, M; Yasukawa, K, 2011)
"The gastro-protective and antioxidant effects of methanol extract of Ficus asperifolia bark on indomethacin induced gastric ulcer were investigated in male rats."7.77Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats. ( Bolarinwa, AF; Oyeyemi, WA; Raji, Y; Shittu, ST, 2011)
" The present study was conducted to test for the possible gastroprotective effect of nicotinamide utilizing an acute indomethacin-induced gastric ulcer model."7.76Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent. ( Abdallah, DM, 2010)
"To evaluate, for the first time, the efficacy of copper-indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial oxidative damage, and renal toxicity in rat models."7.76Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. ( Bonin, AM; Davies, NM; Dillon, CT; Fukuda, C; Hambley, TW; Lay, PA; Teng, XW; Yáñez, JA, 2010)
"Gastric ulcers were induced in mice with a single dose of indomethacin."7.76Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine. ( Bandyopadhyay, SK; Chatterjee, A; Chattopadhyay, S; Dey, A; Guha, P, 2010)
"The protective effects of telmisartan, the angiotensin II-receptor antagonist, were investigated in rats with type 2 diabetes mellitus exposed to acute gastric ulceration."7.76Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. ( Al-Sultan, AI; Fouad, AA; Gomaa, W; Yacoubi, MT, 2010)
" We reported previously that melatonin (N-acetyl-5-methoxy tryptamine), an antioxidant and anti-inflammatory agent, prevents indomethacin-induced gastric ulcers."7.76Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. ( Ganguly, K; Reiter, RJ; Sharma, AV; Swarnakar, S, 2010)
"The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model."7.76Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G, 2010)
"This study investigated the possible mechanisms underlying the gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats."7.75Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. ( Amin, RS; Hassan, MK; Heeba, GH, 2009)
"The role of the arginine-metabolism in the healing action of the Myristica malabarica phenol malabaricone B (mal B) and omeprazole against indomethacin-induced stomach ulceration in mouse was investigated."7.75Regulation of arginase/nitric oxide synthesis axis via cytokine balance contributes to the healing action of malabaricone B against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B, 2009)
"We conclude that ATL-313 does not inhibit the mucosal damaging effect of indomethacin, but it does block secondary injury due to stomach inflammation."7.75Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. ( Jin, M; Koizumi, S; Linden, J; Odashima, M; Ohnishi, H; Otaka, M; Watanabe, S, 2009)
"Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice."7.75Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. ( Bandyopadhyay, SK; Chattopadhyay, S; Dey, A; Guha, P, 2009)
" polium) in indomethacin-induced gastric ulcer in rats."7.75The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats. ( Amini, M; Azarpira, N; Fattahi, MR; Mehrabani, D; Panjehshahin, MR; Rezaee, A; Saberi-Firouzi, M; Tanideh, N, 2009)
"Telmisartan is an angiotensin II T1 receptor blocker (ARB) with partial peroxisome proliferator-activated receptor gamma (PPARgamma) agonistic properties; two actions that are suggested to be efficacious for protecting against gastric ulcers."7.75Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats. ( Amin, E; Ashour, O; Morsy, M; Rofaeil, R, 2009)
"To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers."7.75EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009)
" The results of ulcerogenic studies indicate that the gastric ulcerogenecity of plant extract is lower than the indomethacin in the rat's stomach."7.74The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. ( Heidari, MR; Khazaeli, P; Mehrabani, M; Pardakhty, A; Vahedian, M; Yakhchali, M; Zahedi, MJ, 2007)
" In the present study, we examined the effect of alendronate on the healing of acetic acid-induced gastric ulcers in rats and investigated the mechanism involved in this action both in vivo and in vitro using the rat gastric epithelial cell line (RGM1)."7.74Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. ( Aihara, E; Amagase, K; Hayashi, S; Nishikawa, K; Takeuchi, K, 2007)
"APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties."7.74Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Bhattacharya, S; Chattopadhyay, S, 2007)
"The healing activity of malabaricone B and malabaricone C, the major antioxidant constituents of the spice Myristica malabarica against the indomethacin-induced gastric ulceration in mice has been studied."7.74Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK, 2008)
"The drugs, mal B and mal C could effectively heal indomethacin-induced stomach ulceration in mice by promoting angiogenesis."7.74Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration. ( Bandivdeker, AH; Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B, 2008)
"The present study was undertaken to evaluate the potential of the rhizomes of the Indian medicinal plant, Picrorhiza kurroa in healing indomethacin-induced acute stomach ulceration in mice and examine its capacity to modulate oxidative stress and the levels of prostaglandin (PGE2) and EGF during the process."7.74Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B; Nag, SK, 2008)
"Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels."7.74Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S, 2008)
" However, the role of MMPs in indomethacin-induced gastric ulcer and its healing process are not clearly understood."7.73Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. ( Banerjee, A; Ganguly, K; Kundu, P; Maity, P; Sharma, AV; Swarnakar, S, 2005)
"Reactive oxygen species (ROS) are thought to be involved in the gastric ulcer formation induced by indomethacin, a typical nonsteroidal anti-inflammatory drug."7.73Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats. ( Shigemi, R; Soeda, T; Tsuneyoshi, M; Utsumi, H; Yamada, K; Yao, T; Yasukawa, K, 2006)
"To study the effects of amphetamine, an indirect-acting adrenomimetic compound on the indomethacin-induced gastric ulcerations in rats."7.73Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats. ( Birt, MA; Cuparencu, B; Dumitrascu, DL; Krausz, TL; Sandor, V, 2006)
" (methanolic extract) and its action against indomethacin (a non-steroidal anti-inflammatory drug) plus pyloric ligation (PL)-induced gastric ulcers in rats."7.73Antisecretory and antiulcer activity of Asparagus racemosus Willd. against indomethacin plus phyloric ligation-induced gastric ulcer in rats. ( Bhatnagar, M; Sisodia, SS, 2006)
"We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation."7.72Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003)
"The acetone soluble fraction from a crude methanol extract of Stryphnodendron adstringens stem bark (AFSAB) was evaluated in acute (ethanol, indomethacin and hypothermic restraint-stress) and chronic (acetic acid) models of gastric ulceration and on basal and bethanechol-stimulated gastric acid secretion in rats."7.71The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats. ( Lima, JC; Martins, DT; Rao, VS, 2002)
"We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism."7.71Effects of diacerein on indomethacin-induced gastric ulceration. ( Ohmori, K; Tamura, T; Yokoyama, T, 2001)
" at an effective anti-inflammatory dose to rats with pre-existing acetic acid-induced gastric ulcer, NS-398 caused a statistically significant delay of ulcer healing."7.70Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats. ( Dyer, RD; Gilbertsen, RB; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B; Schrier, D; Song, Y, 1998)
"The healing of experimental gastric ulcers induced in rats is consistently delayed upon chronic treatment with indomethacin."7.70A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers. ( Amagase, K; Okabe, S, 1999)
" Our aim is to determine the antiinflammatory activity of deferiprone, an oral iron chelator, in experimental colitis and gastritis."7.70Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats. ( Ablin, J; Karmeli, F; Okon, E; Rachmilewitz, D; Shalev, O, 1999)
" In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection."7.70The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000)
" The spatial and temporal gelatinolytic activities of MMP-2 and MMP-9 were analyzed as a function of ulcer age, in homogenates of rat, indomethacin-induced, chronic gastric ulcers."7.70Matrix metalloproteinases 2 and 9 in indomethacin-induced rat gastric ulcer. ( Ahonen, J; Inkinen, K; Lempinen, M; Wolff, H, 2000)
"The influence of (+/-)-verapamil and hydralazine on stress- and various chemically-induced gastric ulcers in rats together with their influence on various biochemical parameters which affect the development of the induced ulcers was examined."7.69Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats. ( al-Bekairi, AM; al-Rajhi, AM; Tariq, M, 1994)
"Indomethacin delays healing of experimental gastric ulcers."7.69Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin. ( Flogerzi, B; Halter, F; Peskar, BM; Schmassmann, A; Tarnawski, A; Varga, L, 1995)
"Effects of treatment with free radical scavengers in the healing process of acetic acid-induced gastric ulcer on the ulcer aggravation induced by indomethacin were investigated."7.69Effects of free radical scavengers on indomethacin-induced aggravation of gastric ulcer in rats. ( Kondo, M; Matsuyama, K; Naito, Y; Nishimura, S; Yagi, N; Yoshikawa, T, 1995)
" Homozygous Ptgs1 mutant mice survive well, have no gastric pathology, and show less indomethacin-induced gastric ulceration than wild-type mice, even though their gastric prostaglandin E2 levels are about 1% of wild type."7.69Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. ( Chulada, PC; Ghanayem, BI; Goulding, EH; Kim, HS; Kluckman, KD; Langenbach, R; Lee, CA; Loftin, CD; Mahler, JF; Morham, SG; Smithies, O; Tiano, HF, 1995)
" The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss."7.69Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995)
"This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process."7.69Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995)
"We have examined whether or not repeated treatment with indomethacin delays the healing of kissing gastric ulcers induced in rats."7.69Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats. ( Nozue, C; Okabe, S; Tsukimi, Y, 1996)
" This same dose of omeprazole significantly reduced gastric ulcer formation induced by indomethacin despite significant (> 80%) inhibition of gastric mucosal prostaglandin E2 (PGE2) formation."7.69Omeprazole prevents indomethacin-induced gastric ulcers in rabbits. ( Feldman, M; Kallal, SM; Lee, M, 1996)
"The study was performed to examine whether indomethacin administered during the initial period of acetic acid-induced gastric ulcer healing affects future ulcer recurrence."7.69Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins. ( Arakawa, T; Fukuda, T; Higuchi, K; Kobayashi, K; Takaishi, O; Tarnawski, A; Watanabe, T; Yamasaki, K, 1996)
"We found indomethacin aggravates healed gastric ulcers (ulcer relapse) in rats."7.69Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. ( Asano, S; Inada, I; Maeda, R; Murakami, I; Sato, F; Satoh, H; Shino, A, 1997)
" Experimental gastric lesions were induced by water-immersion restraint stress, indomethacin and 80% ethanol in rats; whereas duodenal ulcers were produced by treatment of rats with cysteamine."7.69Effect of quinacrine, a phospholipase A2 inhibitor on stress and chemically induced gastroduodenal ulcers. ( Al Moutaery, AR; Tariq, M, 1997)
"We examined the effect of NC-1300-O-3 on the healing of acetic acid-induced gastric ulcers in male Donryu rats."7.68Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats. ( Inoue, K; Okabe, S; Takagi, K, 1993)
"Repeated administration of indomethacin delays the healing of acetic acid-induced gastric ulcers in rats, but the underlying mechanism remains unclear."7.68Mechanism by which indomethacin delays gastric ulcer healing in the rat: inhibited contraction of the ulcer base. ( Ogihara, Y; Okabe, S, 1993)
"Repeated administration of indomethacin or prednisolone for 2 weeks apparently delayed the healing of initial gastric ulcers induced by acetic acid injection in rats."7.68Effects of indomethacin and prednisolone on the different stages of healing of acetic acid-induced gastric ulcers in the rat. ( Ogihara, Y; Okabe, S, 1993)
"Repeated administration of indomethacin markedly delays spontaneous healing of experimental gastric ulcers induced in rats."7.68Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. ( Hirose, H; Okabe, S; Takeuchi, K, 1991)
"Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats."7.68Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats. ( Nagai, H; Okabe, S; Wang, JY, 1990)
"We examined the effects of orally administered human epidermal growth factor (hEGF) on healing of acetic acid-induced gastric ulcers in rats."7.68Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. ( Imoto, Y; Kuwahara, Y; Okabe, S; Sunagawa, Y, 1990)
"Levamisole, in doses similar to those required to observe immunostimulation in animals, antagonized dose-dependently, in rats, gastric ulcers produced by necrotizing agents (HCl and ethanol) and NSAIDs (indomethacin and piroxicam) without affecting the anti-inflammatory properties of these latter drugs."7.67The effect of levamisole on gastric ulcers induced in the rat by anti-inflammatory and necrotizing agents. ( Evangelista, S; Maggi, CA; Meli, A, 1984)
" Acutely induced gastric ulcers or erosions such as Shay ulcers, water-immersion stress-, indomethacin-, aspirin-, or prednisolone-induced erosions were all markedly inhibited by oral or intraduodenal administration of 10-100 mg/kg of omeprazole."7.67Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984)
"The interaction between reserpine and nonsteroidal anti-inflammatory agents ( NSAIA ) in producing experimental gastric ulcers was studied in rats."7.67Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats. ( Radmanović, BZ; Sćepović, Z, 1984)
"We examined the effect of human epidermal growth factor (hEGF) on the healing rate of gastric ulcers induced in rats."7.67Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. ( Kuwahara, Y; Okabe, S, 1989)
"Effects of systemically administered gamma-aminobutyric acid (GABA) on indomethacin-induced gastric ulceration were studied in rats."7.67Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors. ( Hara, S; Morioka, S; Satoh, K; Yanagihara, S, 1988)
"We examined the mechanism by which repeated administration of indomethacin significantly delays the natural healing of experimental gastric ulcers induced in rats."7.67Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin. ( Okabe, S; Takeuchi, K; Wang, JY; Yamasaki, S, 1989)
"Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug."7.67Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. ( Fielder, FG; Ginsberg, RS; Godin-Ostro, E; Slusher, MA; Soehngen, EC; Weiner, AL, 1988)
"We investigated whether the trophic actions of prostaglandins, omeprazole, and indomethacin on gastric mucosa lead to accelerated healing of gastric ulcers in the rat."7.67Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. ( Baumgartner, A; Halter, F; Inauen, W; Kayser, S; Koelz, HR; Schürer-Maly, CC; Wyss, PA, 1988)
"The purpose of these studies was to determine the role played by endogenous prostaglandins in the development of gastric ulcers produced by indomethacin, and of duodenal ulcers produced by mepirizole in rats."7.67Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats. ( Jacobson, ED; Joffe, SN; Robert, A; Tabata, K, 1987)
"Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats."7.67Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985)
"With the carrageenin food oedema assay, we studied in rats the effects of indomethacin on inflammation, gastric ulcers and lipid peroxide levels."7.67Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats. ( Planas, JM; Puig-Parellada, P, 1985)
" D-penicillamine showed a dose dependent antiulcerogenic effect in both gastric ulcer models."7.67The effect of D-penicillamine in different experimental gastric ulcer models in the rat. ( Bálint, GA; Varró, V, 1985)
"Gastric ulcer was provoked by indomethacine (20 mg/kg s."7.66The relationships between indomethacine-induced gastric ulcer, ulcer protection by cimetidine and prostacyclin and the cAMP system of the gastric fundic mucosa in the rat. ( Bata, M; Fiegler, M; Jávor, T; Morón, F; Mózsik, G, 1982)
"Effects of indomethacin on healed partially healed gastric ulcers in the dog were studied."7.66Does indomethacin activate healed gastric ulcers in the dog? ( Okabe, S; Tabata, K, 1981)
"Experimental models of chronic and acute peptic ulcerations were produced in the albino rats by means of prolonged starvation and indomethacin administration."7.66Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats. ( Elegbe, RA, 1978)
"Bilateral adrenalectomy markedly aggravated gastric ulcers in rats induced by 5 or 20 mg/kg of indomethacin."7.66The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat. ( Kasuya, Y; Okabe, S; Urushidani, T, 1979)
"The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied."7.65Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977)
"Indomethacin produces gastric ulceration in the rat when given by subcutaneous injection."7.65Effect of salbumatol on acute gastric ulceration induced by indomethacin in the rat. ( Curwain, BP; Fielding, LP; Raute, M, 1977)
"Ionic permeability of the gastric mucosa was measured in six patients with an acute exacerbation of severe generalized rheumatoid arthritis receiving either aspirin and prednisone or aspirin and indomethacin as therapy."7.65Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis. ( Clifton, JA; Ivey, KJ, 1974)
"Dyspeptic symptoms, gastrointestinal bleeding, or the development of anaemia without dyspepsia in patients treated with indomethacin may be manifestations of peptic ulceration."7.64Gastric ulceration occurring during indomethacin therapy. ( Hart, FD; Huskisson, EC; Taylor, RT; Trapnell, DH; Whitehouse, GH, 1968)
"Indomethacin is an indol derivative, non-steroidal, anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects."6.46Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. ( Albayrak, A; Bilici, M; Cadirci, E; Halici, Z; Suleyman, H, 2010)
"Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects."5.91Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1. ( El-Demerdash, E; Hamza, SE; Wahdan, SA, 2023)
"The prevalence of gastric ulcers is increasing worldwide, especially those brought on by non-steroidal anti-inflammatory drugs (NSAIDS), so prevention is extremely crucial."5.91Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats. ( Abu-Risha, SE; Elsisi, AE; Mekky, EF, 2023)
"Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties."5.91Effect of felodipine on indomethacin-induced gastric ulcers in rats. ( Akbaş, EM; Akbaş, N; Gülaboğlu, M; Mammadov, R; Süleyman, B; Süleyman, H, 2023)
"Metformin (500 mg/kg) was given orally for 3 days prior to indomethacin or ethanol challenge."5.72The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats. ( Alican, İ; Aydın, B; Cabadak, H; Cumbul, A; Ercan, F; İpek, BE; Yüksel, M, 2022)
"Gastric ulcer has been a major cause of morbidity and mortality worldwide, and it has been linked to factors such as nutritional deficiency, smoking, stress, and continuous intake of non-steroidal antiinflammatory drugs (NSAIDs)."5.72Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model. ( Carvalho, MF; Costa, EA; Fajemiroye, JO; Fava, SA; Ghedini, PC; Gil, ES; Gomes, EH; Macedo, IYL; Martins, JLR; Pinto, EMH; Rocha, FF; Silva, DM; Silva, ON, 2022)
"Olmesartan (OLM) has potent anti-oxidant and anti-inflammatory characters, yet having limited bioavailability."5.62Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway. ( Darwish, SF; El-Dakroury, WA; Radwan, E; Sallam, AM, 2021)
"Rheumatoid arthritis is an autoimmune inflammatory disease with progressive degradation of cartilage and joints."5.62Nerolidol-beta-cyclodextrin inclusion complex enhances anti-inflammatory activity in arthritis model and improves gastric protection. ( Cavalcanti, MD; de Albuquerque Júnior, RLC; de Lima, CM; de Souza Araújo, AA; de Souza Carvalho, FM; de Souza, EPBSS; Dos Santos Lima, B; Gomes, MVLD; Júnior, LJQ; Marreto, RN; Shanmugan, S; Silva, LAS, 2021)
"Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels."5.62The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021)
"Pinocembrin (PINO) is a natural flavonoid retaining anti-microbial, anti-oxidant, and anti-inflammatory activities."5.62Protective and therapeutic effects of the flavonoid "pinocembrin" in indomethacin-induced acute gastric ulcer in rats: impact of anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms. ( El-Demerdash, AA; Elsherbiny, DA; Esmat, A; Menze, ET; Tadros, MG, 2021)
"Gastric ulcers were induced in male Sprague-Dawley (SD) rats with a single oral dose of 150 mg/kg IND."5.56Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway. ( Cai, X; Chen, X; Hou, X; Peng, J; Peng, Q; Song, H; Xu, F; Yang, T; Yu, R; Zeng, M, 2020)
"Gastric ulcer is one of the most prevalent diseases worldwide."5.51Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach. ( Amiri-Dashatan, N; Dadpay, M; Farrokhi Yekta, R; Goshadrou, F; Koushki, M, 2019)
"The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide."5.51Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice. ( Alves, GM; Assis, ALEM; Athaydes, BR; Campagnaro, BP; Gomes, JVD; Gonçalves, RCR; Kitagawa, RR; Kuster, RM; Nogueira, BV; Pereira, TMC; Rodrigues, RP; Silveira, D, 2019)
"Gastric ulcer is a common problem affecting the gastrointestinal tract."5.51A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats. ( Abdelwahed, MK; Ahmed, EI; Boushra, AF; Elsayed, AM; Ibrahim, NA, 2019)
"Thymol is a monoterpene phenol with many different pharmacological activities."5.48Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model. ( Aysin, F; Cerig, S; Erol, HS; Geyikoglu, F; Koc, K; Ozek, NS; Yilmaz, EG, 2018)
" Each rat to receive nebivolol and omeprazole was given the agent orally (by gavage) daily for 10 days prior to induction of ulcer by oral dosing with INDO."5.43Nebivolol prevents indomethacin-induced gastric ulcer in rats. ( El-Ashmawy, NE; El-Bahrawy, HA; Khedr, EG; Selim, HM, 2016)
"Aliskiren was able to inhibit indomethacin-induced ulcer formation."5.43Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Kose, D; Polat, B; Topcu, A, 2016)
"Indomethacin (IND) is a non-steroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions."5.39Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. ( Abbas, AM; Sakr, HF, 2013)
"Pretreatment with candesartan for 10 days reduced significantly the ulcer index induced by indomethacin injection."5.38Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats. ( Awad, AS; El Morsy, EM; Kamel, R, 2012)
"Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions."5.37Curative effect of selenium against indomethacin-induced gastric ulcers in rats. ( Kim, BW; Kim, JH; Kwon, HJ; Nam, SW, 2011)
"Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e."5.36Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010)
"Rats treated with indomethacin revealed mucosal hemorrhagic lesions, increased microvascular permeability and inhibited prostaglandin E₂ and mucus content."5.36Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E₂, nitric oxide and redox status in indomethacin-induced gastric ulcer model. ( El-Abhar, HS, 2010)
"The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)."5.35Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009)
"Amiodarone is a widely used antiarrhythmic agent."5.34Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats. ( Bayir, Y; Cadirci, E; Dengiz, GO; Halici, Z; Odabasoglu, F; Suleyman, H, 2007)
"Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod."5.33Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005)
"Gastric ulcer is a source of visceral pain."5.33Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006)
"Ketoconazole treatment resulted in significant protection against stress; indomethacin and ethanol induced gastric lesions in rats."5.32Protective effect of ketoconazole against experimentally induced gastric ulcers in rats. ( Al Moutaery, AR, 2003)
"The indomethacin treatment of the premedicated animals with the drug hardly affected either the malondialdehyde (MDA) or superoxide dismutase (SOD) level in gastric tissue while the ulcerative agent itself significantly enhanced both the levels."5.31The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. ( Bandyopadhyay, SK; Pakrashi, A; Pakrashi, SC, 2000)
"Pre-treatment with indomethacin significantly reduced the protective effect of the extract against HCl/ethanol solution to 31%."5.31Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats. ( Dimo, T; Dongo, E; Tan, PV, 2000)
" Gastrointestinal ulceration was assessed, four hours after a single dose and 24 hours following the last dose of a chronic four day dosing regimen, by counting the number of lesions and ulcers present."5.30Comparative evaluation of the severity of gastric ulceration by solid dispersions and coprecipitates of indomethacin. ( Degennaro, MD; Karnachi, AA; Khan, MA; Reddy, IK, 1997)
"Gastric ulcers were produced 5 days after submucosal injection of 20% acetic acid (0."5.29Effect and mechanism of sucralfate on healing of acetic acid-induced gastric ulcers in rats. ( Ogihara, Y; Okabe, S, 1993)
"Indomethacin is a potent and efficacious antiinflammatory agent."5.28Influence of indomethacin amphoteric gel on gastric ulcerogenicity and absorption of indomethacin in rats. ( Dent, J; Eickhoff, WM; Liversidge, GG, 1989)
"Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration."5.08Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. ( Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G, 1997)
" After 30 minutes gastric ulcers were induced by the intragastric application of NSAIDs (20 mg/kg indomethacin, 200 mg/kg aspirin, 200 mg/kg ibuprofen, or 50 mg/kg diclofenac)."5.08Reduction of non-steroidal anti-inflammatory drug induced gastric injury and leucocyte endothelial adhesion by octreotide. ( Angermüller, S; Engel, G; Görlach, E; Kusterer, K; Oldenburg, A; Pohl, T; Scheiman, JM; Tillner, A; Usadel, KH, 1997)
" One hundred patients, free from endoscopically detectable lesions of the gastroduodenal mucosa, affected either by rheumatoid arthritis or osteoarthritis, and candidates for NSAID therapy, were randomly allocated either to 200 mg sulglycotide three times daily (n = 50) or to an indistinguishable placebo (n = 50) for 4 weeks, together with standard NSAID administration (50 mg diclofenac three times daily (n = 50); 50 mg indomethacin three times daily (n = 50))."5.07Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients. ( Ardizzone, S; Bianchi Porro, G; Caruso, I; Montrone, F; Petrillo, M, 1993)
"In the present study, we investigated the gastroprotective potential of HQJZT in a rat model of indomethacin (IND)-induced gastric ulcer and explained the biochemical, cellular, and molecular mechanisms involved."4.84Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms. ( Cai, X; Gao, Q; Lu, J; Ou, C; Peng, Q; Ren, B; Song, H; Wang, X; Xiong, M; Yu, C; Zeng, M; Zhong, M; Zhou, S, 2024)
" pylori infection, indomethacin and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed acetic acid ulcers; and 2) whether or not eradication of the bacteria with drugs at specified times after infection prevents the development of mucosal changes, including gastric adenocarcinoma."4.81[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. ( Ebata, M; Keto, Y; Okabe, S, 2001)
" In this regard, Sarcophyton glaucum-derived secondary metabolites were examined for their preventive activities against indomethacin-induced gastric ulcer."4.31Cembranoids from the Red Sea soft coral Sarcophyton glaucum protect against indomethacin-induced gastric injury. ( Abdel-Naim, AB; Alarif, WM; Alorfi, HS; Alqarni, NM; Bawakid, NO, 2023)
"Unlike quercetin, chlorogenic acid could not prevent gastric ulcers in indomethacin-treated rats."4.31Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration. ( Angkhasirisap, W; Boonyong, C; Jianmongkol, S; Kengkoom, K, 2023)
" The present work aimed to annotate the secondary metabolites from a butanol fraction of apple leaves (BLE), evaluate the gastro-protective and healing effects of this fraction against indomethacin-induced gastric ulcers in rats and to identify its mechanism of action."4.31Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats. ( Abdelfattah, MAO; Abdo, W; Drissi, B; El-Shazly, AM; Mahmoud, MF; Nabil, M; Sobeh, M, 2023)
"), the gastroprotective activity was assessed in various animal models of stomach ulcers caused by acidified ethanol, water constraint stress, indomethacin, (acute), and acid acetic (chronic)."4.31Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves. ( Arunachalam, K; Damazo, AS; Figueiredo, FF; Lima, JCDS; Martins, DTO; Pavan, E; Silva, MJD, 2023)
"The aim of this study was to investigate the potential protective effects of walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats."4.31The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats. ( Hao, Y; Kang, J; Li, Y; Liu, R; Liu, X; Mao, R; Yu, X; Zhu, N, 2023)
" The therapeutic effect of AH seeds extract against indomethacin-induced ulcer in rat model indicated the regenerated membrane integrity, with improved cellular functions and mucus thickness."4.31Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis. ( Idris, S; Khushtar, M; Mishra, A, 2023)
"7 g/kg) or ranitidine (40 mg/kg) were orally administered in rats for three weeks before the induction of gastric ulcer using indomethacin (30 mg/kg, single oral dose)."4.31Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats. ( Bai, L; Bao, M; Bao, T; Chen, Y; Feng, L; Fu, M; Li, Y; Mu, X; Ta, N; Zhang, J, 2023)
"We used the murine re-fed indomethacin (IND) experimental ulcer model."4.31Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT ( Akiba, Y; Kaunitz, JD; Satoh, H; Urushidani, T, 2023)
"This experiment aimed to investigate the preventive effect of ethanol extract (RM) from Chinese sumac fruits on indomethacin-induced gastric ulcer in mice and the underlying mechanisms."4.12Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis. ( Cai, S; Ma, N; Sun, Y; Yi, J; Zhou, L, 2022)
"We investigated the potential gastroprotective effects of chrysin on indomethacin induced gastric ulcers in rats."4.12Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation. ( Kandemir, FM; Küçükler, S; Yıldırım, S, 2022)
"This study investigated the link between forced swim induced acute gastric ulceration, inflammation and MMP-3 along with the possible mechanism of protective efficacy of melatonin."4.12Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade. ( Chatterjee, A; Choudhary, P; Mishra, VK; Pant, S; Roy, T; Swarnakar, S, 2022)
"This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the mechanism behind this protective effect."4.12RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats. ( Bai, L; Bao, T; Chen, Y; Cho, S; Dai, L; Feng, L; Fu, M; Jin, W; Yu, H; Zhang, J, 2022)
" The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy."4.02Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021)
"Curcumin is claimed as a potent protectant against Gastric Ulcer (GU) induced by strong necrotizing agents, including NSAIDs through its antioxidant, anti-inflammatory and gastroprotective activities."4.02Efficacy of a Chitosan-curcumin Mixture in Treating Indomethacininduced Acute Gastric Ulcer in Rats. ( Kaewsuwan, S; Kuadkaew, S; Mahattanadul, S; Phdoongsombut, N; Ungphaiboon, S, 2021)
"This study aimed to investigate the gastroprotective effect of chlorogenic acid (CGA) against Indomethacin (IND)-induced gastric ulcer (GU) in rats and its underlying mechanism, especially through autophagic and apoptotic pathways."4.02Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling. ( Aboulhoda, BE; Ahmed, AAE; Ahmed, MAE; El-Awdan, SA; Mohanad, M, 2021)
" Here, we investigated the gastroprotective potential of the leaf extract on indomethacin-induced gastric ulcer in rats and explored the involved mechanism(s) of action."4.02Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats. ( Abdelfattah, MAO; Abdo, W; El Kharrassi, Y; El-Shazly, AM; Mahmoud, MF; Nabil, M; Sobeh, M, 2021)
" speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs."4.02Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021)
"Liquid raft-forming formulations comprising solid dispersions of glycoside-rich Centella asiatica extract and Eudragit® EPO (GR-SD) were developed to achieve prolonged delivery of the glycosides, asiaticoside (AS) and madecassoside (MS) in the stomach and thus increase the effectiveness of gastric ulcer treatment."3.96Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment. ( Issarachot, O; Mahattanadul, S; Puttarak, P; Wannasarit, S; Wiwattanapatapee, R, 2020)
"The results of this study showed that agomelatine usage in indomethacin-induced gastric ulcer model provides beneficial results."3.96Agomelatine prevents indomethacin-induced gastric ulcer in rats. ( Eraslan, E; Güler, MC; Kurt, N; Tanyeli, A; Yetim, Z, 2020)
" This study investigated the involvement of oxidative stress in the healing and protective potentials of aqueous leave extract of Telfairia occidentalis (TO) on indomethacin induced gastric ulcers in adult Sprague Dawley male rats."3.96Attenuating Effect of Telfairia occidentalis on Oxidative Stress in Indomethacin-induced Gastric Ulcer in Male Rats. ( Adisa, W, 2020)
" Gastric ulcerated rats were administered AG, AG + dexamethasone, or pantoprazole after indomethacin exposure."3.91Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms. ( Abdallah, DM; El-Abhar, HS; El-Lekawy, AM, 2019)
" We monitored the intra- and extracellular redox status in the stomach of rats with indomethacin-induced gastric ulcers using OMRI and investigated the relationship with gastric mucosal damage."3.91In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging. ( Ichikawa, K; Kanbe, T; Mutsumoto, Y; Oda, F; Shigemi, R; Tun, X; Utsumi, H; Yamada, KI; Yasukawa, K, 2019)
" However, there is lack of evidence that fluvoxamine recruits Hsp70 to affect stress-induced gastric ulcer."3.91Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70. ( Ardianto, C; Aryani, T; Dinintia, Y; Khotib, J; Nisak, K; Oktavia, R; Rahmadi, M; Ratnasari, A; Shinta, DW, 2019)
" This study aimed to investigate the possible gastroprotective effects of saccharification on the indomethacin (IND)-induced gastric ulcers in rats using Weissella cibaria- and Saccharomyces cerevisiae-triple fermented H."3.91Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats. ( Bashir, KMI; Cho, HR; Choi, JS; Jung, GW; Ku, SK; Lim, JM; Park, DC; Park, SJ; Song, CH, 2019)
"Safranal and lansoprazole normalized gastric volume and pH, reduced gastric ulcer area and produced gastric protection."3.91Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer. ( Erfanparast, A; Farshid, AA; Imani, M; Mirzakhani, N; Salighedar, R; Tamaddonfard, E; Tamaddonfard, S, 2019)
"Gastric ulceration was experimentally generated by administration of single oral doses of indomethacin (30 mg/kg) to fasted rats."3.91Antiulcer activity of Cyperus alternifolius in relation to its UPLC-MS metabolite fingerprint: A mechanistic study. ( Abdallah, HMI; Efferth, T; Elshamy, AI; Farag, MA; Farrag, ARH; Gendy, AEGE; Hegazy, MF; Khattab, AR; Mohamed, TA, 2019)
"The aim of this paper was to observe the combination therapy with total triterpenoids of Chaenomeles speciosa and omeprazole on indomethacin-induced gastric ulcer in rats, and explore its possible mechanism."3.91[Therapeutic effect of total triterpenoids of Chaenomeles speciosa combined with omeprazole on gastric ulcer induced by indomethacin in rats]. ( He, HB; He, YM; Li, XM; Li, XQ; Qin, HL; Wang, JZ; Xiong, XJ; Zhang, YF; Zou, K, 2019)
"The aim of the study was to investigate the effects of four Aronia melanocarpa-based juices in a rat model of indomethacin-induced gastric ulceration."3.91Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers. ( Denev, P; Eftimov, M; Georgieva, A; Kuzmanov, A; Kuzmanov, K; Kuzmanova, V; Tzaneva, M; Valcheva-Kuzmanova, S, 2019)
"The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats."3.88Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. ( Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H, 2018)
" One of its representative components, the tricyclic triterpenoid β-patchoulone (β-PAE) has demonstrated great anti-inflammatory activity and gastroprotective effect against ethanol-induced gastric injury, but its protective effect against gastric ulcer induced by indomethacin is still unknown."3.88Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. ( Chen, JN; Dou, YX; Huang, QH; Liang, JL; Liu, YH; Nie, J; Su, ZR; Wu, JZ; Wu, QD; Wu, X; Zhuo, JY, 2018)
" The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats."3.88Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats. ( Gupta, G; Hatware, KV; Karri, S; Patil, K; Sharma, S; Shete, M, 2018)
"Severe gastric ulceration induced in rats by administration of indomethacin in combination with cold stress (IND + CS) for 2 h."3.88Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats. ( Fahmy, SR; Sayed, DA; Soliman, AM, 2018)
" Aiming to contribute in the scientific validation about the popular use of Brazilian Green propolis (BGP) against gastritis and gastric ulcer, this work evaluated the antiulcer potential of isolated compounds from BGP, three prenylated p-coumaric acid derivatives and two flavonoids, respectively named: 3,5 diprenyl-4-hydroxycinnamic acid (artepillin C) (1), 3-prenyl-4-dihydroxycinnamoiloxy cinnamic acid (baccharin) (2), 3-prenyl-4-hydroxycinnamic acid (drupanin) (3), aromadendrin-4'-O-methyl-ether (4) and kaempferide (5)."3.88Artepillin C, drupanin, aromadendrin-4'-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action. ( Almeida, MO; Andrade, SF; Arruda, C; Bastos, JK; Boeing, T; Casoti, R; Costa, P; da Silva, LM; da Silva, RCMVAF; Dos Santos, AC; Lemos, M; Mariott, M; Somensi, LB; Souza, P; Stein, BP, 2018)
"This study investigated the gastroprotective effects and the systemic oxidative status of oral kefir pretreatment in albino mice submitted to acute gastric ulcer induced by indomethacin."3.88Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress. ( Alves, GM; Barboza, KRM; Campagnaro, BP; Coco, LZ; Meyrelles, SS; Pereira, TMC; Peters, B; Vasquez, EC, 2018)
"3 M- and indomethacin-induced gastric ulcer were performed in rodents."3.88Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol. ( Beber, AP; Boeing, T; Burci, LM; Cury, BJ; da Silva, CB; da Silva, LM; de Andrade, SF; de Souza, P; Mariano, LNB; Simionatto, E; Somensi, LB, 2018)
" The compounds were evaluated for their anti-inflammatory activity in carrageenan induced rat paw edema model taking rofecoxib and indomethacin as standard drugs."3.85Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect. ( Bali, A; Chaudhari, BB; Sharma, R, 2017)
" The gastroprotective effect of CRG/Ech complexes was investigated on the model of stomach ulcers induced by indomethacin in rats."3.85Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome. ( Davydova, VN; Glazunov, VP; Kravchenko, AO; Mischchenko, NP; Pimenova, EA; Sorokina, IV; Tarbeeva, DV; Yermak, IM, 2017)
""Unhealed gastric ulcers" were induced using indomethacin following the establishment of acetic-acid-induced chronic gastric ulcers."3.85Healing and Antisecretory Effects of Aqueous Extract of ( Amang, AP; Emakoua, J; Enow-Orock, GE; Mbah, G; Mezui, C; Nkwengoua, EZ; Siwe, GT; Tan, PV, 2017)
" The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats."3.85Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats. ( Alkushi, AGR; Elsawy, NAM, 2017)
"This study investigated the gastroprotective effects of N-acetylcysteine (NAC) against indomethacin-induced gastric ulcer in rats."3.85N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms. ( Ali, DA; Katary, MA; Soliman, NA; Zineldeen, DH, 2017)
" After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days."3.85Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. ( Eyoum Bille, B; Kouitcheu Mabeku, LB; Nanfack Nana, B; Nguepi, E; Tchuenteu Tchuenguem, R, 2017)
" The gastroprotective activity of the OECC was investigated using animal models of gastric ulcer induced by the administration of absolute ethanol, acidified ethanol or indomethacin."3.85Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice. ( Coutinho, HDM; da Silva Almeida, JRG; de Albuquerque, TR; de Alencar Silva, A; de Menezes, IRA; de Oliveira, MRC; Oliveira Brito Pereira Bezerra Martins, A; Quintans, LJ; Ribeiro-Filho, J; Vidal, CS, 2017)
"These findings suggest that ZnCl(2), enhances the gastroprotective activity ofrisperidone in indomethacin- induced gastric ulcer."3.83Zinc salt enhances gastroprotective activity of risperidone in indomethacin-induced gastric ulcer. ( Oluwole, FS; Onwuchekwa, C, 2016)
"The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats."3.83Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata. ( Garuba, T; Ismail, NO; Sabiu, S; Sulyman, AO; Sunmonu, TO, 2016)
"These results indicated that lycopene might have a protective effect against indomethacin-induced gastric ulcer and oxidative stress in rats."3.83The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats. ( Avci, H; Boyacioglu, M; Epikmen, ET; Karademir, U; Kum, C; Sekkin, S; Yalinkilinc, HS, 2016)
" The optimized GR formulation was examined for its protective effect on the gastric ulcer induced by indomethacin in albino rabbits compared with lactose tablets."3.83Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits. ( Abu Hashim, II; Badria, FA; Mohamed, EA; Yusif, RM, 2016)
" The aim was to scientifically evaluate the possible gastroprotective effect and the underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats."3.83The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. ( Chen, HM; Chen, XY; Fu, LD; Huang, XQ; Lai, XP; Liang, YZ; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Zhang, X; Zhang, ZB; Zheng, YF, 2016)
" In this study, we identified PA-rich food sources and examined the effects of the food materials on indomethacin-induced stomach ulcer."3.83Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer. ( Afroz, S; Ikoma, T; Kogure, K; Tanaka, T; Tokumura, A; Yagi, A, 2016)
" Models of acute gastric ulcer induction by ethanol and indomethacin and of chronic ulcer by acetic acid were used."3.81Antiulcerogenic activity of Carica papaya seed in rats. ( Argadoña, EJ; Cardoso, CA; Carollo, CA; Carrasco, V; Cordeiro, KW; Freitas, Kde C; Pinto, LA, 2015)
"This study investigated the protective effects of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats."3.81Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats. ( Gomathy, G; Palani, S; Venkatesan, D, 2015)
" Six scoparone derivatives were synthesized and screened for gastroprotective activities against HCl/ethanol- and indomethacin-induced gastric ulcers in rats."3.81Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents. ( Choi, WS; Lee, GR; Lee, SE; Oh, S; Son, DJ, 2015)
" This study investigated the anti-ulcerogenic and antioxidant activities of aqueous extract of Carica papaya seed against indomethacin-induced peptic ulcer in male rats."3.81Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. ( Adaja, MC; Ajiboye, TO; Oloyede, HO; Salawu, MO, 2015)
" However, there is no report on the gastroprotective effect of ASB against indomethacin-induced gastric ulcer."3.81Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats. ( Chen, HM; Chen, XY; Feng, XX; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Yu, XT; Zeng, HF; Zhang, X; Zhang, ZB; Zheng, YF, 2015)
" Antiulcerogenic activity of AcE-NP was also evaluated with an acute gastric ulcer experimental model induced by ethanol and indomethacin."3.81Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity. ( de Carvalho, JE; Foglio, MA; González-Gómez, A; Jorge, MP; Monteiro, KM; Queiroz, Nde C; Reyes-Ortega, F; San Román, J; Servat-Medina, L; Sousa, IM; Zago, PM, 2015)
" In contrary, a clinical report indicated the formation of gastric ulcer by the use of atorvastatin."3.81Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS. ( Atukeren, P; Gümüştaş, K; Gürel, A; Özdemir, O; Özyoğurtçu, H; Uyanik, Ö; Uydeş-Doğan, S; Yildirim, FI, 2015)
" Treatment with MESe also decreased gastric ulceration induced by indomethacin."3.81Gastroprotective bio-guiding study of fruits from Mimusops balata. ( Boeing, T; Bordignon Somensi, L; de Moura Burci, L; Faloni de Andrade, S; Filho, VC; Mota da Silva, L; Santin, JR; Schlickmann, F, 2015)
" All the compounds were evaluated for their anti-inflammatory (carrageenan-induced rat paw edema assay), antioxidant (inhibition of lipid peroxidation) and antiulcer activity (indomethacin-induced gastric damage)."3.81Synthesis, Structure Activity Relationship (SAR), and Biological Activities of Benzylideneacetophenones Derivatives. ( Choudhary, AN; Juyal, V; Kumar, A, 2015)
" Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin."3.801,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2014)
"To investigate the protective effect of DHEA on indomethacin-induced gastric ulcers in rats."3.80The impact of dehydroepiandrosterone on indomethacin-induced gastric lesions in rats. ( Alessa, R; Alkhateeb, M; Bayoumy, NM; Bin-Jaliah, I; Eleawa, S; Sakr, HF, 2014)
"The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats."3.80Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats. ( Agastian, P; Antonisamy, P; Balthazar, JD; Dhanasekaran, M; Duraipandiyan, V; Ignacimuthu, S; Kim, JH, 2014)
" In the present work, we evaluated the healing effect of L-theanine on NSAID (indomethacin)-induced gastric ulcer."3.80L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin. ( Bandyopadhyay, SK; Bera, B; Chatterjee, A; Chatterjee, S; Roy, S, 2014)
" This study investigated the possible mechanisms underlying the gastroprotective effect of escin against indomethacin-induced gastric ulcer in mice."3.80Protective effects of escin against indomethacin-induced gastric ulcer in mice. ( Chu, L; Du, H; Fu, F; Wang, T; Wang, Y; Yang, Y; Yao, L; Zhao, S, 2014)
" For this study, an indomethacin-induced gastric ulcer rat model was used."3.80Gastroprotective activity of violacein isolated from Chromobacterium violaceum on indomethacin-induced gastric lesions in rats: investigation of potential mechanisms of action. ( Al-Dhabi, NA; Antonisamy, P; Arasu, MV; Aravinthan, A; Duraipandiyan, V; Ignacimuthu, S; Kannan, P; Kim, JH, 2014)
" This study aimed to investigate the possible anti-ulcerogenic potential of PA and the underlying mechanism against ethanol, indomethacin and water immersion restraint-induced gastric ulcers in rats."3.80Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats. ( Chen, XY; Huang, P; Jiang, WW; Liang, YZ; Liu, YH; Mo, ZZ; Su, ZR; Xie, JH; Xu, YF; Yu, XD; Zheng, YF, 2014)
" The gastrointestinal injury was accompanied by signs of chronic stress: long-lasting increase in corticosterone blood level, adrenal hypertrophy, thymus involution, and loss of body weight."3.80[Somatic pain sensitivity under indometacin induced gastric and small intestinal injury in rats]. ( Bagaeva, TR; Filaretova, LP; Iarushkina, NI, 2014)
"Gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg)."3.79Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats. ( El-Moselhy, MA; Morsy, MA, 2013)
"The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model."3.79Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice. ( Acharya, K; Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Khatua, S; Mukherjee, A; Mukherjee, S; Paloi, S, 2013)
" The anti-inflammatory activity of 1a-h was investigated by acute carrageenan-induced paw edema in mice using the reference drug indomethacin."3.79Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties. ( Al-Tabakha, MM; Caproiu, MT; Fahelelbom, KM; Limban, C; Missir, AV; Sadek, B, 2013)
" The gastroprotective action of ME was analyzed in gastric ulcers that were induced by ethanol or indomethacin in Wistar male rats."3.79Effect of menthol in experimentally induced ulcers: pathways of gastroprotection. ( Hiruma-Lima, CA; Padovani, CR; Pellizzon, CH; Rozza, AL; Takahira, RK, 2013)
" However, the gastroprotective effect of chronic stress was not manifested and there was no aggravation of indomethacin-induced gastric ulceration, either."3.79Does chronic stress enhance the risk of diseases? ( Filaretova, L; Laszlo, F; Morozova, O; Morschl, E; Zelena, D, 2013)
" The gastroprotective effect of HAE was demonstrated on the indomethacin-induced gastric ulcer model after the administration of extracts."3.79Protective effect of Chresta martii extract against indomethacin-induced gastric lesions in mice. ( Abbet, C; Aguiar, JA; Bezerra, MM; Chaves, HV; Franco, ES; Henriques, AT; Hostettmann, K; Maia, MB; Pereira, KM; Pinto, VP; Silva, AA; Simões-Pires, CA, 2013)
"A series of 3-alkoxy-4-methanesulfonamido acetophenone derivatives were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model."3.78Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents. ( Bali, A; Deb, PK; Ohri, R, 2012)
" Gastric ulceration was induced by indomethacin, scored, and assayed to determine the concentration of mucus, malondialdehyde, catalase, and superoxide dismutase in homogenized samples."3.78The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat. ( Ajeigbe, K; Asuk, A; Emikpe, B; Oladejo, E; Olaleye, S, 2012)
" amara) and its bioactive principles-quassin and 2-methoxycanthin-6-one on gastric ulceration were studied in albino rats."3.78Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats. ( Oloyede, GK; Raji, Y, 2012)
" The oral administration of the Chantaleela recipe reduced ulcer formation in acute gastric ulcer models (EtOH/HCl-, indomethacin-, and stress-induced gastric lesions)."3.78Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe. ( Jaijoy, K; Khonsung, P; Nanna, U; Piyabhan, P; Sireeratawong, S; Soonthornchareonnon, N, 2012)
"The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats."3.78Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. ( Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M, 2012)
"We examined the molecular mechanism of curcumin in a preventive and therapeutic model of indomethacin-induced gastric ulceration with regard to angiogenic processes."3.78Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling. ( Ganguly, K; Maulik, N; Paul, S; Sharma, AV; Swarnakar, S, 2012)
"The pharmacokinetics of ϵ-acetamidocaproic acid (AACA) were evaluated after the intravenous and oral administration of an antiulcer agent, zinc acexamate (ZAC) at a dose of 20 mg kg⁻¹ (ion pairing between zinc and AACA) in rats with indomethacin-induced acute gastric ulcer (IAGU) or indomethacin-induced small bowel inflammation (ISBI)."3.78ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation. ( Choi, YH; Kim, YG; Lee, BK; Lee, MG; Lee, U; Oh, E, 2012)
"Zerumbone (1) showed potent cytoprotective effect against necrotizing agent (HCl) and non-steroidal anti-inflammatory drug (indomethacin) induced gastric ulceration."3.78Antiulcer principle from Zingiber montanum. ( Al-Amin, M; Hossain, CF; Sultana, GN, 2012)
"The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP)."3.78Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity. ( Abdul Hisam, EE; Hasiah, AH; Norhafizah, M; Othman, F; Rofiee, MS; Vasudevan, M; Zakaria, ZA, 2012)
" In all models, URB937 was as effective or more effective than standard analgesic and anti-inflammatory drugs (indomethacin, gabapentin, dexamethasone) and reversed pain-related responses (mechanical hyperalgesia, thermal hyperalgesia, and mechanical allodynia) in a dose-dependent manner."3.78Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. ( Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R, 2012)
"BI prevented the gastric ulceration caused by ethanol and indomethacin treatments."3.78Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb. ( Bonaldo, J; Dall'oglio, EL; de Sousa Júnior, PT; Gazoni, VF; Lemos, LM; Martins, DT; Martins, TB; Silva, MG; Strada, CL; Tanajura, GH, 2012)
"This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer."3.78Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. ( Arcanjo Moura, B; Barbosa Filho, JM; de Almeida Leal, LK; de Barros Viana, GS; de Castro Brito, GA; dos Santos e Silva, G; Fragoso de Freitas, AP; Lopes Souto, A; Rios Vasconcelos, E; Santos Cerqueira, G; Silveira Macedo, D; Souccar, C, 2012)
"The gastroprotective action of synthetic dipeptides glutamyl-tryptophane (EW), iso-valeroyl-glutamyl-tryptophane (ivEW) and nicotinoyl-glutamyl-tryptophane (nEW) in comparison to melatonin was studied in experiments on male with the model indometacine and starvation stress-induced stomach ulcers."3.78[Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin]. ( Malinin, VV; Savateeva-Liubimova, TN; Sivak, KV, 2012)
"The mechanism of indomethacin-induced gastric ulcer healing by ellagic acid (EA) in experimental mice model is described in our study."3.78Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. ( Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A, 2012)
"The preventive and healing properties of Croton urucurana bark methanol extract (CUE) were evaluated in experimental models of acute (ethanol and indomethacin) and chronic (acetic acid) gastric ulcers."3.78Antiulcerogenic effect of Croton urucurana Baillon bark. ( Aparecida Pinto, L; de Cássia Freitas, K; Faloni de Andrade, S; Leite Kassuya, CA; Nazari Formagio, AS; Wolff Cordeiro, K, 2012)
"The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats."3.78Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012)
" Hence, the potential of a new water-soluble GPx mimic, DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) in healing the indomethacin-induced stomach ulceration in mice was examined."3.78DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) accelerates healing of indomethacin-induced stomach ulceration in mice. ( Chakraborty, S; Chattopadhyay, S; Iwaoka, M; Priyadarsini, KI; Subramanian, M; Yadav, SK, 2012)
"This study reports a pharmacological evaluation of anti-inflammatory and anti-ulcer activities of carvacrol, a phenolic monoterpene constituent of essential oils produced by oregano and other several aromatic plants and spices, in experimental models of edema induced by different phlogistic agents and gastric lesions induced by acetic acid."3.78Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano. ( Arcanjo, DD; Guimarães, AG; Machado, FD; Oliveira, FA; Oliveira, RC; Quintans-Júnior, LJ; Silva, ER; Silva, FV; Sousa-Neto, BP, 2012)
" They were subjected to the absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation assays after 30 min."3.78Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. ( Hamid, HA; Hisam, EE; Mohtaruddin, N; Othman, F; Rofiee, MS; Zakaria, ZA, 2012)
"9% for indomethacin-induced acute gastric ulcer (IAGU) rats, respectively] than those of ZAC alone due to the significantly slower renal clearance (CL(R))."3.77Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. ( Choi, YH; Kim, YG; Lee, M; Lee, MG; Lee, U; Oh, E; Suh, JH, 2011)
" Diabetes was induced in rats by a single dose of streptozotocin (STZ) followed by gastric ulceration using indomethacin, and melatonin's action was studied by its application prior to indomethacin exposure."3.77Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. ( Pradeepkumar Singh, L; Swarnakar, S; Vivek Sharma, A, 2011)
"The modulation of the cyclooxygenase-independent pathway by black tea (BT) and its constituent theaflavins (TFs) during their healing action against indomethacin-induced stomach ulceration in mice was investigated."3.77Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing. ( Adhikary, B; Bandyopadhyay, SK; Chand, S; Chattopadhyay, S; Yadav, SK, 2011)
" Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice."3.77Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011)
"To study the effect of aqueous propolis extract (AEP) against indomethacin (Indo)-induced gastric ulcers in irradiated and non-irradiated rats."3.77Anti-ulcerogenic effect of aqueous propolis extract and the influence of radiation exposure. ( El-Ghazaly, MA; Khayyal, MT; Rashed, RR, 2011)
" Acute gastric ulcer was induced using absolute ethanol, HCl/ethanol and indomethacin."3.77Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae). ( Caldas, GF; da Costa, JG; da Nóbrega, RF; da Silva, JB; do Amaral Costa, IM; Rodrigues, FF; Wanderley, AG, 2011)
"5]undecan-8-oxyl (compound 1) and 4-oxo-2,2,6,6-tetraethylpiperidine-1-oxyl (compound 2) in the prevention of gastric ulcers in adjuvant arthritis rats treated with indomethacin was evaluated by monitoring the reaction of reactive oxygen species in gastric tissue with Overhauser-enhanced magnetic resonance imaging (OMRI)."3.77Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats. ( Deguchi, H; Ichikawa, K; Kinoshita, Y; Mito, F; Naganuma, T; Sakai, K; Sato, S; Utsumi, H; Yamada, K; Yamasaki, T; Yamato, M; Yasukawa, K, 2011)
"The gastro-protective and antioxidant effects of methanol extract of Ficus asperifolia bark on indomethacin induced gastric ulcer were investigated in male rats."3.77Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats. ( Bolarinwa, AF; Oyeyemi, WA; Raji, Y; Shittu, ST, 2011)
" The present study was conducted to test for the possible gastroprotective effect of nicotinamide utilizing an acute indomethacin-induced gastric ulcer model."3.76Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent. ( Abdallah, DM, 2010)
"Acute gastric ulcers were induced in rats by the oral administration of indomethacin."3.76The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage. ( Fujisawa, M; Hori, M; Murata, T; Ozaki, H, 2010)
"To evaluate, for the first time, the efficacy of copper-indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial oxidative damage, and renal toxicity in rat models."3.76Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. ( Bonin, AM; Davies, NM; Dillon, CT; Fukuda, C; Hambley, TW; Lay, PA; Teng, XW; Yáñez, JA, 2010)
"Gastric ulcers were induced in mice with a single dose of indomethacin."3.76Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine. ( Bandyopadhyay, SK; Chatterjee, A; Chattopadhyay, S; Dey, A; Guha, P, 2010)
"The protective effects of telmisartan, the angiotensin II-receptor antagonist, were investigated in rats with type 2 diabetes mellitus exposed to acute gastric ulceration."3.76Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. ( Al-Sultan, AI; Fouad, AA; Gomaa, W; Yacoubi, MT, 2010)
"The aim of the study was to evaluate the antiulcer activity of Linum usitatissimum fixed oil against aspirin-, indomethacin-, ethanol-, reserpine-, serotonin- and stress-induced gastric ulceration in rats and histamine-induced gastric ulceration in guinea pigs."3.76Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action. ( Kaithwas, G; Majumdar, DK, 2010)
" We reported previously that melatonin (N-acetyl-5-methoxy tryptamine), an antioxidant and anti-inflammatory agent, prevents indomethacin-induced gastric ulcers."3.76Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. ( Ganguly, K; Reiter, RJ; Sharma, AV; Swarnakar, S, 2010)
"The aim of this work was to study the ability of beta-cyclodextrin (beta-CD) or hydroxypropyl beta-cyclodextrin (HP-beta-CD) to ameliorate the induction of gastric ulcers by a nonsteroidal anti-inflammatory drug, indomethacin or piroxicam, in rats exposed to restraint and hypothermic stress at 4 degrees C."3.76Influence of cyclodextrin complexation with NSAIDs on NSAID/cold stress-induced gastric ulceration in rats. ( Ahmed, MO; Alanazi, FK; Alsarra, IA; Alsheikh, AM; Eltahir, KE; Neau, SH, 2010)
") significantly decreased ethanol- and indomethacin-induced gastric ulcer compared with the vehicle-treated (control) group."3.76Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. ( Hara, H; Kakino, M; Ogawa, K; Oyagi, A, 2010)
"5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats."3.76Anti-ulcer and antioxidant activity of GutGard. ( Agarwal, A; Allan, JJ; Bhaskaran, N; Mukherjee, M; Shekhar, D; Shivaprasad, HN; Srinath, R, 2010)
"The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model."3.76Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G, 2010)
" Results showed that 1-acylated-5-amino-1,2,4-triazole-3-acetates 3a-e showed higher anti-inflammatory activity than the corresponding 5-acylamino derivatives 4a-e in carageenan-induced rat paw edema test with low gastric ulcerogenicity compared with indomethacin."3.75Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity. ( Abdel-Megeed, AM; Abdel-Rahman, HM; Alkaramany, GE; El-Gendy, MA, 2009)
" The prepared compounds were evaluated for their anti-inflammatory activity using carrageenan-induced rat paw edema and compared to a well-known NSAID, indomethacin as a reference drug."3.75Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives. ( Abdel-Aziz, M; Aly, OM; Farag, HH; Morsy, MA; Shoman, ME, 2009)
" The combined anti-inflammatory data from in vitro animal model showed that compounds, 9,11-dibromo-1-(2-furyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 23, 9,11-dibromo-1-(4-methoxy-phenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 24, 9,11-dibromo-1-(4-chloro-phenyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 29 and 9-bromo-1-(4-chloro-phenyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 36 exhibited even more potent anti-inflammatory activity and low gastric ulceration incidence compare to reference standard Indomethacin."3.75A new therapeutic approach in Parkinson's disease: some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents. ( Bhatnagar, SP; Laddha, SS, 2009)
"Leaf fractions of Wilbrandia ebracteata were investigated for anti-ulcerogenic effects in ethanol and indomethacin-induced gastric ulcer assays in mice."3.75Gastric anti-ulcer activity of leaf fractions obtained of polar extract from Wilbrandia ebracteata in mice. ( Coelho, RG; Di Stasi, LC; Gonzalez, FG; Sannomiya, M; Vilegas, W, 2009)
"Despite its potential, use of trans-resveratrol as an anticancer drug is severely constrained because of its tendency to prolong gastric ulceration."3.75Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice. ( Bandyopadhyay, SK; Chattopadhyay, S; Dey, A; Dhyani, MV; Guha, P; Sarkar, B, 2009)
"This study investigated the possible mechanisms underlying the gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats."3.75Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. ( Amin, RS; Hassan, MK; Heeba, GH, 2009)
"The role of the arginine-metabolism in the healing action of the Myristica malabarica phenol malabaricone B (mal B) and omeprazole against indomethacin-induced stomach ulceration in mouse was investigated."3.75Regulation of arginase/nitric oxide synthesis axis via cytokine balance contributes to the healing action of malabaricone B against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B, 2009)
"We conclude that ATL-313 does not inhibit the mucosal damaging effect of indomethacin, but it does block secondary injury due to stomach inflammation."3.75Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. ( Jin, M; Koizumi, S; Linden, J; Odashima, M; Ohnishi, H; Otaka, M; Watanabe, S, 2009)
"Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice."3.75Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. ( Bandyopadhyay, SK; Chattopadhyay, S; Dey, A; Guha, P, 2009)
" polium) in indomethacin-induced gastric ulcer in rats."3.75The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats. ( Amini, M; Azarpira, N; Fattahi, MR; Mehrabani, D; Panjehshahin, MR; Rezaee, A; Saberi-Firouzi, M; Tanideh, N, 2009)
" For this study, ethanol- and indomethacin-induced gastric ulcer models in mice and histopathological assessment were used."3.75Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action. ( de Carvalho, AM; de Sousa, DP; de Sousa, FC; Macêdo, DS; Moura, BA; Neto, MR; Rocha, NF; Silva, MI; Tomé, Ada R; Vasconcelos, SM; Viana, GS, 2009)
" The analgesic activity of the test compounds was determined by phenylbenzoquinone-induced writhing assay and the anti-inflammatory activity was evaluated by the carrageenan-induced rat paw edema model."3.75Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives. ( Colak, MS; Gökçe, M; Küpeli, E; Sahin, MF, 2009)
"Telmisartan is an angiotensin II T1 receptor blocker (ARB) with partial peroxisome proliferator-activated receptor gamma (PPARgamma) agonistic properties; two actions that are suggested to be efficacious for protecting against gastric ulcers."3.75Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats. ( Amin, E; Ashour, O; Morsy, M; Rofaeil, R, 2009)
"To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers."3.75EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009)
"Studies were performed in two different models (ethanol and indomethacin induced gastric ulcer) in wistar rats."3.74Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models. ( Arun, M; Asha, VV, 2008)
"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin are widely used in the treatment of inflammation, fever and pain."3.74Beneficial effects of vegetable oils (corn, olive and sunflower oils) and alpha-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats. ( Atalay, F; Aygun, H; Cadirci, E; Cakir, A; Halici, M; Halici, Z; Odabasoglu, F; Suleyman, H, 2008)
" The results revealed that 100 mg/kg nimesulide produces gastric ulceration in adrenalectomized rats, which is prevented by prednisolone and adrenaline."3.74Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats. ( Cadirci, E; Gocer, F; Hacimuftuoglu, A; Halici, Z; Keles, S; Suleyman, H, 2007)
" The results of ulcerogenic studies indicate that the gastric ulcerogenecity of plant extract is lower than the indomethacin in the rat's stomach."3.74The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. ( Heidari, MR; Khazaeli, P; Mehrabani, M; Pardakhty, A; Vahedian, M; Yakhchali, M; Zahedi, MJ, 2007)
" In the present study, we examined the effect of alendronate on the healing of acetic acid-induced gastric ulcers in rats and investigated the mechanism involved in this action both in vivo and in vitro using the rat gastric epithelial cell line (RGM1)."3.74Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. ( Aihara, E; Amagase, K; Hayashi, S; Nishikawa, K; Takeuchi, K, 2007)
"The effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) on gastric secretion and gastric cytoprotection was evaluated using five different models of gastric ulcers: acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol-induced, indomethacin-induced and ischemia-reperfusion-induced gastric ulcers."3.74Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats. ( Asad, M; Hrishikeshavan, HJ; Pathak, R; Prasad, S, 2007)
" The effect of orally administered SIM was also studied on indomethacin- and ethanol-induced gastric ulcers."3.74Gastric antisecretory and antiulcer effects of simvastatin in rats. ( Al Moutaery, M; Al Rayes, H; Al Swailam, R; Arshaduddin, M; Elfaki, I; Khan, HA; Tariq, M, 2007)
"APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties."3.74Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Bhattacharya, S; Chattopadhyay, S, 2007)
" This study was designed to evaluate its gastroprotective effects on ethanol/HCl, indomethacin and pylorus ligation-induced gastric ulcers in rats."3.74Cytoprotective effects of Bergenia ciliata Sternb, extract on gastric ulcer in rats. ( Gulfraz, M; Kakub, G, 2007)
"The healing activity of the methanol extract of the spice rampatri, Myristica malabarica, (RM) and omeprazole against indometacin-induced stomach ulceration has been studied in a mouse model."3.74Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Maity, B, 2007)
"The healing activity of malabaricone B and malabaricone C, the major antioxidant constituents of the spice Myristica malabarica against the indomethacin-induced gastric ulceration in mice has been studied."3.74Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK, 2008)
"To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model."3.74The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. ( Atamanalap, SS; Aydinli, B; Başoğlu, M; Gündoğdu, C; Gürsan, N; Kiziltunç, A; Oren, D; Oztürk, G; Polat, KY; Süleyman, H; Yildirgan, MI, 2007)
"The drugs, mal B and mal C could effectively heal indomethacin-induced stomach ulceration in mice by promoting angiogenesis."3.74Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration. ( Bandivdeker, AH; Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B, 2008)
"The present study was undertaken to evaluate the potential of the rhizomes of the Indian medicinal plant, Picrorhiza kurroa in healing indomethacin-induced acute stomach ulceration in mice and examine its capacity to modulate oxidative stress and the levels of prostaglandin (PGE2) and EGF during the process."3.74Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B; Nag, SK, 2008)
"Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels."3.74Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S, 2008)
" However, the role of MMPs in indomethacin-induced gastric ulcer and its healing process are not clearly understood."3.73Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. ( Banerjee, A; Ganguly, K; Kundu, P; Maity, P; Sharma, AV; Swarnakar, S, 2005)
"The present study was aimed to evaluate the effect of licofelone, a dual inhibitor of cycloxygenase1/2-5-lipoxygenase against indomethacin-induced gastric damage in rats and mice in order to assess the role of leukotrienes if any, in non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal inflammation."3.73Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation. ( Kulkarni, SK; Patil, CS; Singh, VP, 2005)
" Since compounds with cytoprotective and antioxidant effects can improve healing of gastroduodenal ulcer induced by noxious agents, this work investigated the healing effect of D- 002 on acute and chronic gastric ulcers induced with indomethacin and acetic acid, respectively, in rats."3.73Therapeutic effect of D-002 (abexol) on gastric ulcer induced experimentally in rats. ( Arruzazabala, L; Carbajal, D; Más, R; Molina, V, 2005)
" pylori-associated indomethacin-induced gastric ulcers in rats."3.73Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa. ( Arend, A; Aunapuu, M; Loime, L; Lõivukene, K; Roosaar, P; Selstam, G; Sepp, E; Soom, M; Zilmer, K; Zilmer, M, 2005)
"Reactive oxygen species (ROS) are thought to be involved in the gastric ulcer formation induced by indomethacin, a typical nonsteroidal anti-inflammatory drug."3.73Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats. ( Shigemi, R; Soeda, T; Tsuneyoshi, M; Utsumi, H; Yamada, K; Yao, T; Yasukawa, K, 2006)
"We have investigated the mechanism of indomethacin-induced gastric ulcer caused by reactive oxygen species (ROS) and the gastroprotective effect of curcumin thereon."3.73Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. ( Bandyopadhyay, U; Banerjee, RK; Biswas, K; Chattopadhyay, I; Maity, P, 2006)
"The first patient with chronic paroxysmal hemicrania has been followed for 45 years, and for 33 years with indomethacin treatment."3.73Chronic paroxysmal hemicrania, hemicrania continua and SUNCT: the fate of the three first described cases. ( Sjaastad, O, 2006)
"To study the effects of amphetamine, an indirect-acting adrenomimetic compound on the indomethacin-induced gastric ulcerations in rats."3.73Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats. ( Birt, MA; Cuparencu, B; Dumitrascu, DL; Krausz, TL; Sandor, V, 2006)
" (methanolic extract) and its action against indomethacin (a non-steroidal anti-inflammatory drug) plus pyloric ligation (PL)-induced gastric ulcers in rats."3.73Antisecretory and antiulcer activity of Asparagus racemosus Willd. against indomethacin plus phyloric ligation-induced gastric ulcer in rats. ( Bhatnagar, M; Sisodia, SS, 2006)
" L-carnitine significantly prevented gastric ulcerogenesis induced by indomethacin and decreased the ulcer index macroscopically and histopathologically."3.73Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study. ( Altaner, S; Dokmeci, D; Erkin, B; Turan, FN, 2006)
"The effects of beta-cyclodextrin (betaCD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied."3.72Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin. ( Almeida, AB; Brito, AR; De Azevedo, MB; Durán, N; Haun, M; Justo, GZ; Melo, PS, 2003)
" The carrageenan-induced paw edema, cotton pellet granuloma and indomethacin-induced gastric damage models were used to determine these effects."3.72Anti-inflammatory and antiulcerogenic effects of the aqueous extract of Lobaria pulmonaria (L.) Hoffm. ( Aslan, A; Bayir, Y; Cakir, A; Gocer, F; Halici, M; Karagoz, Y; Odabasoglu, F; Süleyman, H, 2003)
"We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation."3.72Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003)
"This investigation was undertaken to study the effect of methimazole (MMI) on gastric acid secretion and stress and chemically induced gastric ulcer in rats."3.72Methimazole prevents stress and chemical induced gastropathy in rats. ( Al Moutaery, A, 2003)
"Effects of glucocorticoid deficiency followed by corticosterone replacement on the healing of gastric erosions and chronic gastric ulcers have been investigated in rats."3.72[Deficiency of glucocorticoid production delays the healing of acute gastric mucosal erosion and chronic ulcers in rats]. ( Bagaeva, TR; Filaretova, LP; Morozova, OIu; Podvigina, TT, 2003)
"The effects of an aqueous root extract from Rumex patientia (D-1) compared to COX-2 selective inhibitors on indomethacine and ethanol induced stomach ulcers were investigated."3.72Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats. ( Demirezer, LO; Kuruüzüm-Uz, A; Süleyman, H, 2004)
" Four compounds were proved to be as active as indomethacin in animal models of inflammation."3.72Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents. ( Aboulmagd, E; Bekhit, AA; El-Sayed, OA; Park, JY, 2004)
" In the present study, we examined the effect of various COX inhibitors on gastric ulcerogenic and acid secretory responses following daily exposure of the stomach to iodoacetamide (IA) and investigated the role for COX isozyme in gastric protection under subchronic mucosal irritation."3.72Roles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach. ( Hayashi, Y; Murakami, M; Takeeda, M; Takeuchi, K; Yamato, M, 2004)
" We examined the roles of TNF-alpha and dynamics of chemokine expression in gastric ulceration including ulcer recurrence and indomethacin-induced injury."3.72Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha. ( Arakawa, T; Fujiwara, Y; Hamaguchi, M; Higuchi, K; Matsumoto, T; Shiba, M; Tominaga, K; Watanabe, T, 2004)
"The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours)."3.72Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin. ( Antônio, MA; Bighetti, AE; Carvalho, JE; Rosaneli, CF; Sgarbieri, VC, 2004)
" Concerning the gastric effects, lavender oil, linalool and linalyl acetate oral administration protected against acute ethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade."3.72Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil. ( Ballabeni, V; Barocelli, E; Bianchi, A; Bruni, R; Calcina, F; Chiavarini, M; Impicciatore, M, 2004)
") Dubard, have been studied on ethanol, ethanol-indomethacin and pylorus ligated gastric ulcers in experimental animals."3.72Effect of Manilkara hexandra (Roxb.) Dubard against experimentally-induced gastric ulcers. ( Goswami, SS; Santani, DD; Shah, MB, 2004)
"The effects of intracerebroventricular (icv) or subcutaneous (sc) hexarelin (Hexa) administration, against gastric ulcers induced by ethanol (50%, 1 ml/rat/os) or Indomethacin (20 mg/kg/os) were examined in conscious rats."3.72Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat. ( Bulgarelli, I; Guidobono, F; Lattuada, N; Locatelli, V; Netti, C; Pagani, F; Rapetti, D; Sibilia, V; Torsello, A, 2004)
"The acetone soluble fraction from a crude methanol extract of Stryphnodendron adstringens stem bark (AFSAB) was evaluated in acute (ethanol, indomethacin and hypothermic restraint-stress) and chronic (acetic acid) models of gastric ulceration and on basal and bethanechol-stimulated gastric acid secretion in rats."3.71The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats. ( Lima, JC; Martins, DT; Rao, VS, 2002)
" Pre-treatment with the extract (100, 200 and 400 mg/kg) produced a significant and dose-dependent inhibition to the acute gastric ulcers induced by phenylbutazone, indomethacin, 0."3.71Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats. ( Al-Attas, A; Chan, K; Chen, HB; Islam, MW; Ismail, A; Liu, XM; Radhakrishnan, R; Zakaria, MN, 2001)
" The acute gastric ulcer models used were pylorus ligation, indomethacin-induced and ethanol-induced gastric ulcers."3.71Effect of centrally administered prolactin on gastric and duodenal ulcers in rats. ( Abraham, BK; Asad, M; Koumaravelou, K; Ramaswamy, S; Shewade, DG; Vasu, S, 2001)
"The effects of a nitric oxide (NO) releasing derivative of indomethacin (NCX-530) on gastric ulcerogenic and healing responses were evaluated in rats and mice, in comparison with the parent compound indomethacin."3.71Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals. ( Araki, H; Komoike, Y; Mizoguchi, H; Suzuki, K; Takeuchi, K, 2001)
"We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism."3.71Effects of diacerein on indomethacin-induced gastric ulceration. ( Ohmori, K; Tamura, T; Yokoyama, T, 2001)
"Celecoxib and indometacin both decreased the epithelial proliferative response and delayed healing of cryoprobe-induced gastric ulcers."3.71Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats. ( Bjarnason, I; Caldwell, C; Palmer, RH; Sigthorsson, G; Tibble, J, 2001)
" The acute gastric ulcer models used were pylorus ligation, indomethacin, ethanol and histamine induced acute gastric ulcers."3.71Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. ( Abraham, BK; Asad, M; Koumaravelou, K; Ramaswamy, S; Shewade, DG; Vasu, S, 2001)
" The TFF2-deficient mice also showed a significant increase in the degree of gastric ulceration after administration of indomethacin."3.71TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. ( Chen, D; Farrell, JJ; Koh, TJ; Podolsky, DK; Taupin, D; Wang, TC; Zhao, CM, 2002)
"Osmolality changes evoked with intragastric administration of natural honey or mannitol, significantly decreased the gastric ulceration of rats induced by indomethacin."3.71The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat. ( Balint, GA; Galfi, M; Gharzouli, K; Juhasz, A; Rimanoczy, A, 2001)
" In the present study, we investigated the protective effects of these compounds against gastric ulcers induced by acidified ethanol (AE) and indomethacin."3.71A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat. ( Bastaki, SM; Chandranath, SI; Singh, J, 2002)
" pylori infection, indomethacin, and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed gastric ulcers in Mongolian gerbils."3.71Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils. ( Ebata, M; Keto, Y; Okabe, S; Tomita, K, 2002)
"The traditional Chinese medicine Shundao Granules po markedly inhibited the formation of gastric ulcers induced by indomethacin, restraint and pyloric ligatin in rats."3.70[Pharmacological studies of shundao granules on gastrointestinal track]. ( Gu, W; Huang, C; Li, S; Yao, Y, 1998)
"trans-Dehydrocrotonin (DHC), the major diterpene isolated from Croton cajucara Benth, was assayed for antiulcerogenic activity in four induced gastric ulcer models in the rat."3.70Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara. ( Brito, AR; Haun, M; Hiruma-Lima, CA; Nunes, DS; Rodríguez, JA, 1998)
" Inhibition of prostaglandin synthesis by traditional NSAIDs such as indomethacin and diclofenac which non-selectively inhibit both PGHS-1 and PGHS-2, causes gastric and intestinal ulceration and delays gastric ulcer healing in chronic models."3.70Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. ( Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T, 1998)
" In this study, we examined whether this antichemotactic factor as well as chemotactic factors are involved in the indomethacin-induced delayed healing of experimental gastric ulcers."3.70Mechanism by which indomethacin delays the healing of acetic acid-induced ulcers in rats. Role of neutrophil antichemotactic and chemotactic activities. ( Fujita, H; Okabe, S; Takahashi, S, 1998)
"To elucidate the role of cyclooxygenase (COX)-2 in ulcer healing, we compared the effects of NS-398 (COX-2-selective inhibitor) and indomethacin (nonselective COX inhibitor) on the healing of acetic acid-induced gastric ulcers in rats."3.70Role of cyclooxygenase-2 in the healing of gastric ulcers in rats. ( Okabe, S; Shigeta, J; Takahashi, S, 1998)
"Effects of selective cyclooxygenase-2 (COX-2) inhibitors (NS-398) and nitric oxide (NO) -releasing aspirin (NO-ASA) on gastric ulcerogenic and healing responses were examined in comparison with nonselective COX inhibitors such as indomethacin and aspirin (ASA)."3.70Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach. ( Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1998)
" at an effective anti-inflammatory dose to rats with pre-existing acetic acid-induced gastric ulcer, NS-398 caused a statistically significant delay of ulcer healing."3.70Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats. ( Dyer, RD; Gilbertsen, RB; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B; Schrier, D; Song, Y, 1998)
") on gastric ulcers induced by the oral administration of ethanol 50% (EtOH, 2 ml/rat) or indomethacin (indomethacin, 20 mg kg(-1), at a dosing volume of 5 ml) were investigated in rats."3.70Investigation on the mechanisms involved in the central protective effect of amylin on gastric ulcers in rats. ( Guidobono, F; Netti, C; Pagani, F; Sibilia, V; Ticozzi, C, 1998)
" This study examine oxygen free radical production (superoxide anions and hydrogen peroxide), gastric mucosa antioxidant defense mechanisms (glutathione, catalase, superoxide dismutase), the lesion-inducing effects of the generated oxygen free radicals (vascular permeability, lipid peroxidation) and gastric ulceration in rats treated orally with indomethacin at 10 mg/kg at 2 and 6 h after drug administration."3.70Role of antioxidants in gastric mucosal damage induced by indomethacin in rats. ( Hassan, A; Martin, E; Puig-Parellada, P, 1998)
" CR 2945 was about as efficacious as ranitidine against the indomethacin- and ethanol-induced gastric ulcers and the cysteamine-induced duodenal ulcer in rats."3.70Characterization of antisecretory and antiulcer activity of CR 2945, a new potent and selective gastrin/CCK(B) receptor antagonist. ( Impicciatore, M; Letari, O; Makovec, F; Mennuni, L; Revel, L, 1999)
"Since the sexual dimorphism of gastroduodenal ulcers is well known and might possibly relate to the actions of sex hormones, we studied the role of the female sex steroids, progesterone and 17beta-estradiol in cysteamine-induced mucosal ulcers in female Wistar rats (200-220 g)."3.70Dual effect of female sex steroids on drug-induced gastroduodenal ulcers in the rat. ( Drago, F; Làszlò, F; Montoneri, C; Varga, C, 1999)
" The gastric ulcerogenic response to indomethacin was markedly worsened in AA rats, depending on the degree of arthritic change."3.70Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide. ( Kato, S; Kunikata, T; Nishijima, M; Takeuchi, K; Tanaka, A, 1999)
"The healing of experimental gastric ulcers induced in rats is consistently delayed upon chronic treatment with indomethacin."3.70A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers. ( Amagase, K; Okabe, S, 1999)
"2 mmol/kg) on gastric ulcer on rats, induced by indomethacin was investigated."3.70Antiulcer effect of the N- and O-beta-D-glucopyranosides of 5-aminosalicylic acid. ( Csípõ, I; Pusztai, F; Szabó, G; Sztaricskai, F; Takács, IE, 1999)
" Our aim is to determine the antiinflammatory activity of deferiprone, an oral iron chelator, in experimental colitis and gastritis."3.70Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats. ( Ablin, J; Karmeli, F; Okon, E; Rachmilewitz, D; Shalev, O, 1999)
"Indomethacin (2 mg/100 g body weight), induces haemorrhagic gastric ulcers in albino rats."3.70Gastric mucosal cellular changes induced by indomethacin (NSAID) in male albino rats. ( Ahamed, RN; Sagar, V, 1999)
"The gastric ulcerogenic response to indomethacin was markedly increased in AA rats, depending on the degree of arthritic change."3.70The roles of nitric oxide and prostaglandins in alterations of ulcerogenic and healing responses in adjuvant-induced arthritic rat stomachs. ( Kato, S; Kunikata, T; Mizoguchi, H; Takeuchi, K; Tanaka, A, 2000)
" In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection."3.70The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000)
"Dothiepin, a tricyclic antidepressant, significantly inhibited the development of gastric ulcers induced by alcohol, aspirin, indomethacin and Shay's pyloric ligation."3.70Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids. ( Abdul Salam, CA; Nag Chaudhuri, AK; Pal, S; Sen, S; Sen, T, 2000)
" The spatial and temporal gelatinolytic activities of MMP-2 and MMP-9 were analyzed as a function of ulcer age, in homogenates of rat, indomethacin-induced, chronic gastric ulcers."3.70Matrix metalloproteinases 2 and 9 in indomethacin-induced rat gastric ulcer. ( Ahonen, J; Inkinen, K; Lempinen, M; Wolff, H, 2000)
"Studies were undertaken on the effect of a crude (TC) and an alkaloid fraction (TA) of the leaf extracts of Tylophora conspicua on indomethacin-induced gastric ulceration and gastric acid secretion in male albino rats."3.70Antiulcerogenic effects of Tylophora conspicua in male rats. ( Adesanwo, JK; Hammed, AI; Ogunwande, IA; Raji, Y, 2000)
"In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied."3.70[Celecoxib vs indomethacin and acute gastric lesions in rats]. ( Aramberry, LJ; Cesolari, JA; Esnarriaga, JM; Laudanno, OM; Maglione, CB; Piombo, G; Rista, L; Sambrano, JS, 2000)
" To evaluate whether immunosuppressants have a preventive effect against indomethacin-induced gastrointestinal damage, we investigated the effects of prednisolone, cyclosporin, and the newly developed immunosuppressant FK-506 in intracolonically indomethacin-treated rats: 24 mg/kg of indomethacin, administered intracolonically for two days, caused gastric ulcers and two types of small intestinal ulcers (longitudinal ulcers and scattered small ulcers)."3.69Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats. ( Fujishima, M; Hizawa, K; Iida, M; Kuroki, F; Matsumoto, T; Nakamura, S, 1994)
"The influence of (+/-)-verapamil and hydralazine on stress- and various chemically-induced gastric ulcers in rats together with their influence on various biochemical parameters which affect the development of the induced ulcers was examined."3.69Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats. ( al-Bekairi, AM; al-Rajhi, AM; Tariq, M, 1994)
"Indomethacin delays healing of experimental gastric ulcers."3.69Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin. ( Flogerzi, B; Halter, F; Peskar, BM; Schmassmann, A; Tarnawski, A; Varga, L, 1995)
"Effects of treatment with free radical scavengers in the healing process of acetic acid-induced gastric ulcer on the ulcer aggravation induced by indomethacin were investigated."3.69Effects of free radical scavengers on indomethacin-induced aggravation of gastric ulcer in rats. ( Kondo, M; Matsuyama, K; Naito, Y; Nishimura, S; Yagi, N; Yoshikawa, T, 1995)
"The effects of a ranitidine-zinc complex and ranitidine alone were compared in three different experimental models (pyloric ligation, ethanol and indomethacin) of gastric ulceration in the rat."3.69Cytoprotective and antisecretory activity of a ranitidine-zinc complex. ( Bravo, L; Bulbena, O; Conchillo, A; Mola, C; Navarro, C, 1995)
") inhibited mepirizole-induced duodenal ulcers."3.69YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats. ( Akuzawa, S; Ito, H; Kamato, T; Kobayashi, A; Miyata, K; Nagakura, Y; Nishida, A; Takinami, Y; Yamano, M; Yuki, H, 1994)
" The effect of intravenous CGRP or intragastric capsaicin on gastric ulceration induced by 100 mmol/L HCl and indomethacin was studied in intact and endogenous CGRP-depleted rats."3.69A role for calcitonin gene-related peptide in protection against gastric ulceration. ( Bunnett, NW; Debas, HT; Gray, JL; Mulvihill, SJ; Orloff, SL, 1994)
" Homozygous Ptgs1 mutant mice survive well, have no gastric pathology, and show less indomethacin-induced gastric ulceration than wild-type mice, even though their gastric prostaglandin E2 levels are about 1% of wild type."3.69Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. ( Chulada, PC; Ghanayem, BI; Goulding, EH; Kim, HS; Kluckman, KD; Langenbach, R; Lee, CA; Loftin, CD; Mahler, JF; Morham, SG; Smithies, O; Tiano, HF, 1995)
" The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss."3.69Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995)
"This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process."3.69Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995)
"Indomethacin induces gastric ulcerations and decreases cell proliferation in the gastric ulcer margin."3.69Indomethacin interferes with epidermal growth factor binding and proliferative response of gastric KATO III cells. ( Arakawa, T; Fujiwara, Y; Halter, F; Schmassmann, A; Tarnawski, A, 1995)
"The present study was undertaken to determine the effect of a combination of selenium and vitamin E on stress and chemical-induced gastric ulcers in rats."3.69Effect of vitamin E and selenium on hypothermic restraint stress and chemically-induced ulcers. ( al-Moutairy, AR; Tariq, M, 1996)
"We have examined whether or not repeated treatment with indomethacin delays the healing of kissing gastric ulcers induced in rats."3.69Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats. ( Nozue, C; Okabe, S; Tsukimi, Y, 1996)
" Gastric ulcers were induced in young, adult, and aged rats using serosal or mucosal (kissing ulcers) application of acetic acid."3.69Influence of age on natural and delayed healing of experimentally-induced gastric ulcers in rats. ( Andrews, FJ; O'Brien, PE; Penney, AG, 1996)
" This same dose of omeprazole significantly reduced gastric ulcer formation induced by indomethacin despite significant (> 80%) inhibition of gastric mucosal prostaglandin E2 (PGE2) formation."3.69Omeprazole prevents indomethacin-induced gastric ulcers in rabbits. ( Feldman, M; Kallal, SM; Lee, M, 1996)
"The study was performed to examine whether indomethacin administered during the initial period of acetic acid-induced gastric ulcer healing affects future ulcer recurrence."3.69Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins. ( Arakawa, T; Fukuda, T; Higuchi, K; Kobayashi, K; Takaishi, O; Tarnawski, A; Watanabe, T; Yamasaki, K, 1996)
"Studies were performed in three models of acute gastric mucosal damage (induced by oral ethanol, aspirin and indomethacin) and a model of chronic gastritis (induced by 7 day treatment with iodoacetamide) in rats to establish the role of leukotrienes (LTs) in the pathogenesis of these lesions."3.69Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. ( Gyömber, E; Rainsford, KD; Szabo, S; Vattay, P, 1996)
" The effect of amylin on gastric ulcers induced by oral administration of indomethacin (Indo, 20 mg kg-1 at a dosing volume of 5 ml) or ethanol 50% (EtOH, 1 ml/rat) was investigated in conscious rats."3.69Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats. ( Guidobono, F; Netti, C; Pagani, F; Pecile, A; Sibilia, V; Ticozzi, C, 1997)
"We found indomethacin aggravates healed gastric ulcers (ulcer relapse) in rats."3.69Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. ( Asano, S; Inada, I; Maeda, R; Murakami, I; Sato, F; Satoh, H; Shino, A, 1997)
" Experimental gastric lesions were induced by water-immersion restraint stress, indomethacin and 80% ethanol in rats; whereas duodenal ulcers were produced by treatment of rats with cysteamine."3.69Effect of quinacrine, a phospholipase A2 inhibitor on stress and chemically induced gastroduodenal ulcers. ( Al Moutaery, AR; Tariq, M, 1997)
"The aim of this study was to examine the synthesis of sulfated glycosaminoglycans during normal healing of experimental acetic acid-induced gastric ulcer in rats and to investigate the effect of indomethacin, a drug known to delay ulcer healing, on this synthesis using an in vivo labelling system."3.69Changes in sulfated macromolecules produced in vivo during normal and indomethacin-delayed ulcer healing in rats. ( Andrews, FJ; Comper, WD; Lyons, KC; O'Brien, PE, 1997)
"The present study investigates the antisecretory and antiulcer mechanisms of a new indenopyridazinone derivative previously reported to inhibit gastric acid secretion in pylorus-ligated rats and to prevent gastric ulcerations induced by indomethacin or ethanol in the same animal species."3.69Study of the antisecretory and antiulcer mechanisms of a new indenopirydazinone derivative in rats. ( Ballabeni, V; Barlocco, D; Barocelli, E; Chiavarini, M; Dal Piaz, V; Impicciatore, M; Vianello, P, 1997)
"Immunohistological staining was done using the antibodies for the proliferating cell nuclear antigen prolyl 4-hydroxylase and alpha-smooth muscle actin in acetic acid induced gastric ulcers in rats."3.69Kinetics of fibroblasts in ulcer healing in rats: interference with indomethacin. ( Arisawa, T; Asai, J; Goto, H; Hase, S; Hayakawa, T; Hirose, Y; Niwa, Y; Tsukamoto, Y, 1997)
"The biosynthesis of sulfated mucin in gastric tissue was investigated in cold-stress and indomethacin (CSI)-induced gastric ulcer models."3.69Effect of cold-stress and indomethacin on the biosynthesis of gastric sulfated mucin in rats. ( Higuchi, S; Isobe, Y; Kijima, H; Kiuchi, Y; Muramatsu, M, 1997)
"Chronic gastric ulcers were induced with acetic acid in male Wistar rats and then treated with either aspirin (100 mg/kg/day), indomethacin (2 mg/kg/day), PDGF-BB (0."3.69Platelet-derived growth factor reverses the effects induced by NSAIDs on ulcer healing. ( Arceiz, E; Lanas, A; Ortego, J; Sáinz, R, 1997)
"We examined the effect of NC-1300-O-3 on the healing of acetic acid-induced gastric ulcers in male Donryu rats."3.68Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats. ( Inoue, K; Okabe, S; Takagi, K, 1993)
"Repeated administration of indomethacin delays the healing of acetic acid-induced gastric ulcers in rats, but the underlying mechanism remains unclear."3.68Mechanism by which indomethacin delays gastric ulcer healing in the rat: inhibited contraction of the ulcer base. ( Ogihara, Y; Okabe, S, 1993)
"Repeated administration of indomethacin or prednisolone for 2 weeks apparently delayed the healing of initial gastric ulcers induced by acetic acid injection in rats."3.68Effects of indomethacin and prednisolone on the different stages of healing of acetic acid-induced gastric ulcers in the rat. ( Ogihara, Y; Okabe, S, 1993)
" The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac."3.68NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993)
"We have tested the action of cloprostenol a relatively stable analogue of PGF2 alpha in experimentally induced gastric ulcer in rats by contention stress or indomethacin."3.68Influence of cloprostenol in the experimentally induced ulcer in rats. ( Adomnicăi, M; Dobrescu, G; Nechifor, M; Negru, A; Neughebauer, BI, 1992)
"This study was designed to elucidate the role of leukotrienes (LT) in indomethacin-induced gastric ulcers in relation to effects of clinically available anti-allergic drugs, azelastine (Azeptin, CAS 58581-89-8) and oxatomide (CAS 60607-34-3)."3.68Reduction of adverse effects of indomethacin by anti-allergic drugs in rat stomachs. ( Goto, H; Hamajima, E; Hoshino, H; Ohara, A; Ozawa, T; Sugiyama, S; Tsukamoto, Y, 1992)
"The role of oxygen-derived free radicals in the pathogenesis of acute gastric ulceration induced by indomethacin (Indo) was investigated in rats."3.68Role of oxygen-derived free radicals in indomethacin-induced gastric injury. ( Meddings, JB; Vaananen, PM; Wallace, JL, 1991)
" The compound had no activity against cysteamine-induced duodenal ulcers and lost its cytoprotective activity in adrenalectomised rats."3.68BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat. ( Bruno, M; Grassi, A; Ippen, J; Thomas, G, 1991)
"The effects of dopamine (DA) agonists and antagonists were investigated on indomethacin--and restraint stress (6 hr at RT)--induced gastric ulcer formation in rats."3.68Possible prostaglandin-dopamine interactions during experimental gastric ulcer formation. ( Khanna, N; Ray, A; Sen, P, 1990)
"Repeated administration of indomethacin markedly delays spontaneous healing of experimental gastric ulcers induced in rats."3.68Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. ( Hirose, H; Okabe, S; Takeuchi, K, 1991)
" SK&F 105809 inhibited oedema and inflammatory-cell infiltration in arachidonic acid-induced inflammation in the mouse ear and rat paw as well as in carrageenan- and monosodium urate crystal-induced peritonitis."3.68Pharmacological profile of SK&F 105809, a dual inhibitor of arachidonic acid metabolism. ( Adams, J; Bender, P; Dimartino, MJ; Griswold, DE; Hanna, N; Kirsh, R; Marshall, PJ; Newton, J; Schwartz, L, 1990)
"We studied the effect of the angiotensin converting enzyme inhibitor, captopril, on two models of gastric ulcers; oxyphenbutazone and ethanol-induced lesions."3.68Effect of captopril on oxyphenbutazone and ethanol-induced gastric lesions in rats. ( Bhounsule, SA; Diniz D'Souza, RS; Hede, SS; Pereira, JS, 1990)
"Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats."3.68Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats. ( Nagai, H; Okabe, S; Wang, JY, 1990)
"We examined the effects of orally administered human epidermal growth factor (hEGF) on healing of acetic acid-induced gastric ulcers in rats."3.68Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. ( Imoto, Y; Kuwahara, Y; Okabe, S; Sunagawa, Y, 1990)
"Levamisole, in doses similar to those required to observe immunostimulation in animals, antagonized dose-dependently, in rats, gastric ulcers produced by necrotizing agents (HCl and ethanol) and NSAIDs (indomethacin and piroxicam) without affecting the anti-inflammatory properties of these latter drugs."3.67The effect of levamisole on gastric ulcers induced in the rat by anti-inflammatory and necrotizing agents. ( Evangelista, S; Maggi, CA; Meli, A, 1984)
"0 mg/kg) and DMPG (10-40 micrograms/kg) overcame morphine-induced constipation in a dose-related manner, the respective ED50s being 0."3.67M&B 28,767: a potent anti-secretory and anti-ulcer PG analogue. A comparative study with 16, 16' dimethyl PGE2 methylester. ( Banerjee, AK; Christmas, AJ; Crowshaw, K; Heazell, MA; Ivers-Read, GC; Saunders, LC; Wyatt, D, 1984)
" Pelsonin a combination of indomethacin and sodium salicylate (1:10 ratio) has a cytoprotective effect against acidic-alcohol induced gastric necrosis, and it does not induce intestinal ulceration."3.67Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat. ( Ezer, E; Matuz, J; Pallagi, K; Szporny, L, 1984)
"The effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on various experimental gastric ulcers and gastric secretion in experimental animals was compared with that of cimetidine and cetraxate."3.67Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals. ( Aratani, S; Enomoto, H; Kimura, K; Mimura, K; Nomura, A; Ueda, F, 1984)
"This study shows that human fundic mucosa generates various PGs, particularly PGE2, and thromboxanes and this generation appears to be significantly lower in gastric ulcer than in duodenal ulcer patients or normal subjects."3.67Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC). ( Konturek, SJ; Kopp, B; Kwiecień, N; Obtułowicz, W; Oleksy, J; Sito, E, 1984)
" FCE 20700 was more potent than PGE2 in the prevention of stress-induced gastric ulcers (ED50 = 262 and 787 mcg/kg) and indomethacin-induced intestinal ulcers (ED50 = 557 and 4569 mcg/kg), and showed the same potency as PGE2 in the prevention of ethanol (ED50 = 9."3.67Cytoprotective and antisecretory effects of 11-deoxy-13,14-didehydro-16(s)-methyl PGE2 methylester (FCE 20700). ( Arrigoni, C; Ceserani, R; Faustini, F; Mizzotti, B; Toti, D, 1984)
" Acutely induced gastric ulcers or erosions such as Shay ulcers, water-immersion stress-, indomethacin-, aspirin-, or prednisolone-induced erosions were all markedly inhibited by oral or intraduodenal administration of 10-100 mg/kg of omeprazole."3.67Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984)
"The interaction between reserpine and nonsteroidal anti-inflammatory agents ( NSAIA ) in producing experimental gastric ulcers was studied in rats."3.67Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats. ( Radmanović, BZ; Sćepović, Z, 1984)
" AY-28,200 blocked acetylsalicylic acid and stress-induced gastric ulcers but was inactive against indomethacin-induced gastric ulcers."3.67Gastric antisecretory and antiulcer/cytoprotective effects of 2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester. ( Borella, LE; DiJoseph, JF, 1989)
" Whereas gastric ulcers were produced by ulcerogenic agents including indomethacin, aspirin and reserpine, beside hypothermic restraint stress and by pylorus ligated Shay rat technique."3.67Gastroprotective activity of ginger zingiber officinale rosc., in albino rats. ( Ageel, AM; al-Yahya, MA; Mossa, JS; Parmar, NS; Rafatullah, S; Tariq, M, 1989)
"We examined the effect of human epidermal growth factor (hEGF) on the healing rate of gastric ulcers induced in rats."3.67Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. ( Kuwahara, Y; Okabe, S, 1989)
" Indomethacin-induced gastric ulcer was inhibited by cysteamine of 132 and 264 mumol, i."3.67[The role of sulfhydryls in indomethacin-induced gastric mucosal injury in rats]. ( Liu, JL; Wang, CC; Zhang, XJ, 1989)
") inhibited restraint and water-immersion-induced stress, ulcers, indometacin- and absolute ethanol-induced gastric ulcers and mepirizole-induced duodenal ulcers in rats in a dose-dependent manner."3.67Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats. ( Bickel, M; Goto, M; Hayashi, S; Herling, AW; Sakurai, M; Tanaka, T, 1989)
" Magaldrate afforded protection against gastric necrotic lesions induced by absolute ethanol (ED50, as magaldrate, 419 mg/kg); gastric ulcers induced by acidified acetylsalicylic acid (ED50 540 mg/kg), stress (cold restraint, ED50 388 mg/kg), indometacin (ED50 281 mg/kg), and pylorus ligation; and intestinal ulcers induced by cysteamine (ED50 243 mg/kg) and indometacin (ED50 184 mg/kg)."3.67Cytoprotective and antiulcer activities of the antacid magaldrate in the rat. ( Borella, LE; DiJoseph, JF; Mir, GN, 1989)
"Effects of systemically administered gamma-aminobutyric acid (GABA) on indomethacin-induced gastric ulceration were studied in rats."3.67Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors. ( Hara, S; Morioka, S; Satoh, K; Yanagihara, S, 1988)
", prevented the formation of gastric ulcers induced by exposure to stress, pylorus-ligation, both pylorus-ligation and acetylsalicyclic acid, indometacin or reserpine in rats."3.67Effects of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)-acetoxyacetamide hydrochloride (TZU-0460), a histamine H2-receptor antagonist, on gastric acid secretion and ulcer formation. ( Mieda, M; Sakuma, H; Shiratsuchi, K; Tarutani, M, 1985)
"We examined the mechanism by which repeated administration of indomethacin significantly delays the natural healing of experimental gastric ulcers induced in rats."3.67Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin. ( Okabe, S; Takeuchi, K; Wang, JY; Yamasaki, S, 1989)
" On the other hand, protective effects of PGM on diarrhea induced by arachidonic acid in mice were about 1/2 times as potent as those of IND in both 1 and 4 hr pretreatments."3.67[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract]. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1986)
"Adrenalectomy enhances the degree of gastric ulcers induced in rats by indomethacin or acetylsalicylic acid (ASA), but not that induced by 96% ethanol."3.67Further studies on the role of the adrenals in the capsaicin-sensitive "gastric defence mechanism". ( Evangelista, S; Giuliani, S; Maggi, CA; Meli, A, 1988)
" However they possess antiulcer properties lower than the reference compound against Indomethacin-induced gastric ulcers."3.67[Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure]. ( Evangelista, S; Ghelardoni, M; Meli, A; Pestellini, V; Viti, G, 1988)
"Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug."3.67Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. ( Fielder, FG; Ginsberg, RS; Godin-Ostro, E; Slusher, MA; Soehngen, EC; Weiner, AL, 1988)
" The effect of the inhibition of endogenous prostaglandin generation by indomethacin on these parameters was also investigated in this model of endotoxin shock."3.67Indomethacin potentiates endotoxin-induced blood flow reduction and histological injury in rat gastric mucosa. ( Guth, PH; Leung, FW; Piqué, JM; Whittle, BJ; Yonei, Y, 1988)
"We investigated whether the trophic actions of prostaglandins, omeprazole, and indomethacin on gastric mucosa lead to accelerated healing of gastric ulcers in the rat."3.67Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. ( Baumgartner, A; Halter, F; Inauen, W; Kayser, S; Koelz, HR; Schürer-Maly, CC; Wyss, PA, 1988)
"Clonidine and paraaminoclonidine prevented the formation of indomethacin-induced gastric ulcers in female rats."3.67Antiulcer activity of clonidine: lack of effect on gastric prostaglandins. ( Ben-Zvi, Z; Leibson, V, 1987)
" The anti-inflammatory properties of FPP028 were evaluated through the carrageenan induced paw edema and the cotton pellet induced granuloma and compared with the activity of indomethacin, phenylbutazone, and isoxicam; as a result, the activity of FPP028 was shown to be similar to that of the latter compounds."3.67Pharmacological activity of FPP028 (2-phenylpyrazolo-4-ethyl-4,7-dihydro [1,5a]pyrimidin-7-one) a new non-steroid anti-inflammatory agent. ( Banchelli, G; Bianchini, F; Ignesti, G; Pecori-Vettori, L; Pirisino, R; Rafanelli, D; Raimondi, L, 1986)
"The purpose of these studies was to determine the role played by endogenous prostaglandins in the development of gastric ulcers produced by indomethacin, and of duodenal ulcers produced by mepirizole in rats."3.67Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats. ( Jacobson, ED; Joffe, SN; Robert, A; Tabata, K, 1987)
"Gastric ulcerations induced in rats by a combination of indomethacin and cold-stress (5 +/- 1 degrees C) for 6 hr were more severe than those induced by indomethacin or cold-stress alone."3.67Effects of indomethacin and cold-stress on gastric acid secretion and ulceration. The effects of anti-acid secretory agents in rats. ( Aihara, H; Arai, I; Hirose, H; Muramatsu, M; Usuki, C, 1987)
"The main constituents of the ethanol extract of Pyrenacantha staudtii leaves were identified to be triterpenoid saponins and orally this extract was shown to protect rats from developing gastric ulcers induced by various experimental models: drugs (indomethacin, serotonin), cold-restraint stress and Shay rat."3.67Gastrointestinal studies of Pyrenacantha staudtii leaf extracts. ( Aguwa, CN; Okunji, CO, 1986)
"Capsaicin desensitization increases the degree of indomethacin-induced gastric ulcers in sham-operated but not in adrenalectomized rats."3.67Evidence for a role of adrenals in the capsaicin-sensitive "gastric defence mechanism" in rats. ( Evangelista, S; Maggi, CA; Meli, A, 1986)
" It inhibited dose dependently gastric ulcers produced by acidified aspirin, water immersion and restraint stress."3.67Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins. ( Aihara, H; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Muramatsu, M; Piastucki, I; Radecki, T; Tanaka, M, 1986)
"The effect of zinc sulphate on stomach ulceration produced by ethanol and indomethacin was examined in rats."3.67Effects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosa. ( Cho, CH; Koo, MW; Ogle, CW; Wong, SH, 1985)
" Acetazolamide increased the gastric ulcerogenicity of indomethacin, but inhibited gastric ulcers produced by acidified aspirin."3.67Ulcer formation and cytoprotection by acetazolamide. ( Davis, JP; Kolbasa, KP; Lancaster, C; Nezamis, JE; Robert, A, 1985)
" prevented formation of ulcers induced by serotonin, indomethacin, acetylsalicylic acid or stress (acute ulcer models), its effect being greater against gastric ulcers induced by serotonin."3.67Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103). ( Hoshina, K; Naruchi, T; Takeshita, T; Yamazaki, N, 1985)
"Effects of several non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin (ASA), indomethacin (IM), flurbiprofen (FP), ibuprofen (IP), phenylbutazone (PBZ) and flufenamic acid (FA) were studied on the gastric ulceration and gastric acid secretion induced by restraint and water-immersion stress (RWIS) or various secretagogues in rats."3.67Possible involvement of non-steroidal anti-inflammatory drugs in vagal-mediated gastric acid secretion in rats. ( Aihara, H; Arai, I; Hirose, H; Muramatsu, M; Okuyama, S, 1985)
"Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats."3.67Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985)
"With the carrageenin food oedema assay, we studied in rats the effects of indomethacin on inflammation, gastric ulcers and lipid peroxide levels."3.67Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats. ( Planas, JM; Puig-Parellada, P, 1985)
" Oral or intraduodenal administration of AG 629 in a dose range of 25-100 mg/kg inhibited water-immersion stress ulcer, exertion ulcer, Shay ulcer, indometacin- and acetylsalicylic acid (ASA)-induced gastric ulcer, and indomethacin-induced small intestinal ulcer in rats, histamine-induced gastric ulcer in guinea pigs, and ASA-induced gastric ulcer in dogs, though it was not effective against cysteamine-induced duodenal ulcer in rats."3.67Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers. ( Hirata, T; Inada, I; Inatomi, N; Maki, Y; Satoh, H; Sino, A, 1985)
" D-penicillamine showed a dose dependent antiulcerogenic effect in both gastric ulcer models."3.67The effect of D-penicillamine in different experimental gastric ulcer models in the rat. ( Bálint, GA; Varró, V, 1985)
" Three of the most active compounds (4, 18a, and 18e) were tested in the rat adjuvant arthritis model and found to be essentially equivalent in activity to indomethacin."3.66Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides). ( Carter, GW; Cimon, DG; Garmaise, DL; Paris, GY; Swett, L; Young, P, 1980)
"Gastric ulcer was provoked by indomethacine (20 mg/kg s."3.66The relationships between indomethacine-induced gastric ulcer, ulcer protection by cimetidine and prostacyclin and the cAMP system of the gastric fundic mucosa in the rat. ( Bata, M; Fiegler, M; Jávor, T; Morón, F; Mózsik, G, 1982)
" Fenflumizole was comparable to or weaker than indomethacin in models of acute inflammation (carrageenin paw oedema and pleurisy, rats, ultraviolet erythema, guinea-pigs) and stronger than indomethacin as an analgesic (writhing, mice)."3.66Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative. ( Corell, T; Hasselmann, G, 1983)
"The erythro version of 1, 4,-dimercapto-2, 3,-butanediol provided a significant protection against experimental gastric ulcer induced by indomethacin, while it was ineffective in stress ulcer of rats."3.66Different protective effects of dimercapto-butanediol stereoisomers in experimental gastric ulceration. ( Balint, GA; Varró, V, 1983)
"Sodium salicylate (SA) has been reported to inhibit the formation of gastric ulcerations induced by aspirin, indomethacin, and absolute ethanol."3.66Effect of prostaglandin synthesis inhibitors on neurotensin and sodium salicylate-induced gastric cytoprotection in rats. ( Adcock, JE; Hernandez, DE; Nemeroff, CB; Prange, AJ, 1983)
") also inhibited gastric ulcers provoked by aspirin, aspirin + acid, indomethacin and stress (cold-restraint) in rats."3.66Gastric antisecretory and cytoprotective activities of SCH 28080. ( Chiu, PJ; Derelanko, MJ; Long, JF; Steinberg, M, 1983)
" However, SM powder had no effect on water-immersion stress- or aspirin-induced gastric lesions and mepirizole-induced duodenal ulcers."3.66[Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats]. ( Ikenishi, H; Ohmi, F; Okabe, S; Takaoka, A; Takeuchi, K, 1983)
"Effects of indomethacin on healed partially healed gastric ulcers in the dog were studied."3.66Does indomethacin activate healed gastric ulcers in the dog? ( Okabe, S; Tabata, K, 1981)
" Gastric ulceration was induced by physical restraint in rats and by indomethacin treatment in dogs."3.66Gastrointestinal myoelectric activity disturbances in gastric ulcer disease in rats and dogs. ( Bueno, L; Fioramonti, J, 1980)
"A combination of indomethacin and diflunisal, a new salicylic acid derivative, when given to rats, gave a greater reduction in the size of permanganate induced granulomas and less gastric irritation, than either drug given alone."3.66Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal. ( Conti, P; Continenza, A, 1980)
"Experimental models of chronic and acute peptic ulcerations were produced in the albino rats by means of prolonged starvation and indomethacin administration."3.66Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats. ( Elegbe, RA, 1978)
" 4 Studies with cimetidine, have shown that the enhancement of anti-oedema effects produced by fasting are due to specific pharmacological properties of indomethacin rather than to non specific effects related to the presence of gastric ulcers."3.66Influence of fasting and cimetidine on the relationship between ulcerogenic and anti-inflammatory properties of indomethacin. ( Del Soldato, P; Meli, A; Volterra, G, 1979)
"Bilateral adrenalectomy markedly aggravated gastric ulcers in rats induced by 5 or 20 mg/kg of indomethacin."3.66The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat. ( Kasuya, Y; Okabe, S; Urushidani, T, 1979)
" Indomethacin treatment precipitated gastric ulceration, which led to the formation of a gastro-colic fistula."3.66Gastro-colic fistula secondary to benign gastric ulceration. ( Taylor, R, 1978)
"Gastric ulceration produced by aspirin and indomethacin was compared in acutely stressed and non-stressed rats."3.66Aspirin- and indomethacin-induced ulcers and their antagonism by antihistamines. ( Brown, PA; Sawrey, JM; Vernikos, J, 1978)
" Concomitant oral administration of aspirin or subcutaneous administration of indomethacin revealed an aggravation of aspirin-induced gastric ulcers by betamethasone valerate and inhibition of indomethacin-induced intestinal ulcers by beta-methasone dipropionate."3.66[Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs (author's transl)]. ( Ishihara, Y; Izumi, K; Kunimi, H; Okabe, S; Tabata, K; Uchida, N, 1978)
" In the carrageenan edema test, eight compounds exhibited higher antiinflammatory activities than did indomethacin."3.656,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity. ( Kubo, S; Tagawa, H; Tsukada, W; Ueno, K; Yoshioka, T, 1976)
"The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied."3.65Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977)
"Indomethacin produces gastric ulceration in the rat when given by subcutaneous injection."3.65Effect of salbumatol on acute gastric ulceration induced by indomethacin in the rat. ( Curwain, BP; Fielding, LP; Raute, M, 1977)
"Ionic permeability of the gastric mucosa was measured in six patients with an acute exacerbation of severe generalized rheumatoid arthritis receiving either aspirin and prednisone or aspirin and indomethacin as therapy."3.65Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis. ( Clifton, JA; Ivey, KJ, 1974)
"Dyspeptic symptoms, gastrointestinal bleeding, or the development of anaemia without dyspepsia in patients treated with indomethacin may be manifestations of peptic ulceration."3.64Gastric ulceration occurring during indomethacin therapy. ( Hart, FD; Huskisson, EC; Taylor, RT; Trapnell, DH; Whitehouse, GH, 1968)
"Topiramate pretreatment also reduced the contents of tissue malonaldehyde, enhanced ferric reducing antioxidant power value and glutathione levels, and increased the activity of superoxide dismutase, catalase, and glutathione peroxidase in gastric mucosa compared to the model group."3.11Gastroprotective effect of topiramate on indomethacin-induced peptic ulcer in rats: Biochemical and histological analyses. ( Andishfar, N; Esmaeilzadeh, Z; Ghasemnejad-Berenji, M; Jafari, A; Khezri, MR, 2022)
"Indomethacin is an indol derivative, non-steroidal, anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects."2.46Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. ( Albayrak, A; Bilici, M; Cadirci, E; Halici, Z; Suleyman, H, 2010)
" To investigate the mechanism of action, conducted assays of antioxidant activity, measured the dosage of inflammatory cytokines, quantified mucus, treated with inhibitors (IND, L-NAME, glibenclamide, and yohimbine), performed histopathological analysis, and measured gastric acid secretion."2.44Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models. ( Arunachalam, K; Damazo, AS; Figueiredo, FF; Martins, DTO; Muller, JAI; Oliveira, DM; Serio, BFD; Silva, MJD; Venturini, CL, 2024)
"Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects."1.91Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1. ( El-Demerdash, E; Hamza, SE; Wahdan, SA, 2023)
"The prevalence of gastric ulcers is increasing worldwide, especially those brought on by non-steroidal anti-inflammatory drugs (NSAIDS), so prevention is extremely crucial."1.91Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats. ( Abu-Risha, SE; Elsisi, AE; Mekky, EF, 2023)
"Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties."1.91Effect of felodipine on indomethacin-induced gastric ulcers in rats. ( Akbaş, EM; Akbaş, N; Gülaboğlu, M; Mammadov, R; Süleyman, B; Süleyman, H, 2023)
"Metformin (500 mg/kg) was given orally for 3 days prior to indomethacin or ethanol challenge."1.72The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats. ( Alican, İ; Aydın, B; Cabadak, H; Cumbul, A; Ercan, F; İpek, BE; Yüksel, M, 2022)
"Gastric ulcer has been a major cause of morbidity and mortality worldwide, and it has been linked to factors such as nutritional deficiency, smoking, stress, and continuous intake of non-steroidal antiinflammatory drugs (NSAIDs)."1.72Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model. ( Carvalho, MF; Costa, EA; Fajemiroye, JO; Fava, SA; Ghedini, PC; Gil, ES; Gomes, EH; Macedo, IYL; Martins, JLR; Pinto, EMH; Rocha, FF; Silva, DM; Silva, ON, 2022)
"Olmesartan (OLM) has potent anti-oxidant and anti-inflammatory characters, yet having limited bioavailability."1.62Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway. ( Darwish, SF; El-Dakroury, WA; Radwan, E; Sallam, AM, 2021)
"Rebamipide (REB) a potent anti-ulcer agent, has not been exploited to its full potential, owing to it extremely poor solubility, leading to highly diminutive bioavailability (<10%)."1.62Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies. ( Chadha, R; Dureja, J; Jindal, A; Karan, M; Singh, R; Tomar, S, 2021)
"Rheumatoid arthritis is an autoimmune inflammatory disease with progressive degradation of cartilage and joints."1.62Nerolidol-beta-cyclodextrin inclusion complex enhances anti-inflammatory activity in arthritis model and improves gastric protection. ( Cavalcanti, MD; de Albuquerque Júnior, RLC; de Lima, CM; de Souza Araújo, AA; de Souza Carvalho, FM; de Souza, EPBSS; Dos Santos Lima, B; Gomes, MVLD; Júnior, LJQ; Marreto, RN; Shanmugan, S; Silva, LAS, 2021)
"Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels."1.62The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021)
"Indomethacin treatment revealed histopathological changes and ulcer scoring and ulcer index were markedly increased."1.62Possible protective effect of TNF-α inhibition and triad NO/cGMP/VEGF activation on gastric ulcer in rats. ( Abd Al Haleem, EN; Arafa, HMM; Ibrahim, FAM; Zaytoon, SAB, 2021)
"Pinocembrin (PINO) is a natural flavonoid retaining anti-microbial, anti-oxidant, and anti-inflammatory activities."1.62Protective and therapeutic effects of the flavonoid "pinocembrin" in indomethacin-induced acute gastric ulcer in rats: impact of anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms. ( El-Demerdash, AA; Elsherbiny, DA; Esmat, A; Menze, ET; Tadros, MG, 2021)
"Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate-Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline)."1.56Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats. ( Atusiimirwe, JK; Ayikobua, ET; Kalange, M; Kasolo, J; Kasozi, KI; Matama, K; Munanura, EI; Namulema, J; Nansunga, M; Okpanachi, AO; Semuyaba, I; Ssempijja, F; Zirintunda, G, 2020)
"Gastric ulcers were induced in male Sprague-Dawley (SD) rats with a single oral dose of 150 mg/kg IND."1.56Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway. ( Cai, X; Chen, X; Hou, X; Peng, J; Peng, Q; Song, H; Xu, F; Yang, T; Yu, R; Zeng, M, 2020)
"Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-inflammatory drugs (NSAIDs), stress conditions, and alcohol, resulting in an inflammatory condition in the gastric mucosa."1.56Involvement of nitric oxide pathway in the anti-inflammatory effect of modafinil on indomethacin-, stress-, and ethanol -induced gastric mucosal injury in rat. ( Dehpour, AR; Dejban, P; Eslami, F; Jahansouz, M; Rahimi, N; Takzare, N, 2020)
"Gastric ulcer is one of the most prevalent diseases worldwide."1.51Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach. ( Amiri-Dashatan, N; Dadpay, M; Farrokhi Yekta, R; Goshadrou, F; Koushki, M, 2019)
"Corticosterone levels were elevated under formation of gastric erosions (4 hours after IM injection) but decreased following their healing (24 and 48 hours IM injection)."1.51Effects of stress preconditioning on vulnerability of gastric and small intestinal mucosa to ulcerogenic action of indomethacin in rats. ( Filaretova, LP; Yarushkina, NI, 2019)
"Paeonol pretreatment diminished gastric oxidative stress and restored the gastric antioxidant capacity by elevating gastric gene expression of HO-1 and protein expression of NQO1."1.51Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats. ( Hafez, HM; Mohamed, MZ; Morsy, MA; Zenhom, NM, 2019)
"The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide."1.51Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice. ( Alves, GM; Assis, ALEM; Athaydes, BR; Campagnaro, BP; Gomes, JVD; Gonçalves, RCR; Kitagawa, RR; Kuster, RM; Nogueira, BV; Pereira, TMC; Rodrigues, RP; Silveira, D, 2019)
"Gastric ulcer is a common problem affecting the gastrointestinal tract."1.51A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats. ( Abdelwahed, MK; Ahmed, EI; Boushra, AF; Elsayed, AM; Ibrahim, NA, 2019)
"Gastric ulcer was induced by a single oral gavage of 48 mg/kg IND."1.48Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats. ( Anvari, M; Bagheri, SM; Mirjalili, A; Momeni-Asl, H; Yadegari, M; Zare-Mohazabieh, F, 2018)
"Indomethacin (0."1.48Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats. ( Chen, F; Gong, J; Jiang, J; Li, H; Tan, Y; Zhang, J; Zhang, X; Zhang, Z, 2018)
"Thymol is a monoterpene phenol with many different pharmacological activities."1.48Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model. ( Aysin, F; Cerig, S; Erol, HS; Geyikoglu, F; Koc, K; Ozek, NS; Yilmaz, EG, 2018)
"Crocin is a novel agent that has potential in the prevention of ulceration induced by NSAIDs."1.43Protective activity of crocin against indomethacin-induced gastric lesions in rats. ( Ahmadi, I; Khani, MZ; Mard, SA; Mojahedin, S; Neisi, N; Pipelzadeh, MH; Teimoori, A, 2016)
"Fluoxetine (20 mg/kg) was administered IP for 14 days."1.43Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats. ( Elsayed Elsayad, M; Sabri Ali, H; Salem Sokar, S, 2016)
" Each rat to receive nebivolol and omeprazole was given the agent orally (by gavage) daily for 10 days prior to induction of ulcer by oral dosing with INDO."1.43Nebivolol prevents indomethacin-induced gastric ulcer in rats. ( El-Ashmawy, NE; El-Bahrawy, HA; Khedr, EG; Selim, HM, 2016)
"Aliskiren was able to inhibit indomethacin-induced ulcer formation."1.43Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Kose, D; Polat, B; Topcu, A, 2016)
"Indomethacin is a nonsteroidal anti-inflammatory drug, which is known to produce serious side effects, causing ulcerative lesions."1.42Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms. ( Cantali-Ozturk, C; Deniz, R; Kolgazi, M; Ozdemir-Kumral, ZN; Sirvanci, S; Yeğen, BC; Yuksel, M, 2015)
"sacarolha in the treatment of gastric ulcers and that it has a multi-targeted action."1.42Helicteres sacarolha A. St.- Hil. et al.: gastroprotective and possible mechanism of actions in experimental animals. ( Balogun, SO; Damazo, AS; de Oliveira Martins, DT, 2015)
"As numerous herbal products have been used as dietary supplements or functional foods, the demands of the pharmacokinetic and pharmacodynamic characteristics of active compounds are increasing in order to secure a consistent outcome (i."1.42In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. ( Chae, HS; Chin, YW; Choi, YH; Kim, YJ, 2015)
"Ilaprazole is a novel proton pump inhibitor that has been marketed as an oral therapy for acid-related diseases in China and Korea."1.40Intravenous ilaprazole is more potent than oral ilaprazole against gastric lesions in rats. ( Gong, ZH; Hou, XM; Hu, HT; Lu, XQ; Su, RB; Xie, HZ; Yu, G, 2014)
" However, these preventive effects of SAC were dependent on dosage of SAC; higher dose above 10 μM paradoxically aggravated NSAID-induced inflammation."1.40S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibition. ( Hahm, KB; Han, YM; Jung, MK; Kangwan, N; Kim, EH; Lee, SY; Park, JM, 2014)
"Metyrapone pretreatment allowed us to prevent the acute corticosterone response to CRF and avoid the lasting effects of glucocorticoid deficiency."1.40[Metyrapone effect on gastroprotective action of corticotropin-releasing factor administered centrally against indomethacin-induced gastric injury]. ( Bagaeva, TR; Filaretova, LP; Miazina, MA, 2014)
"Indomethacin (IND) is a non-steroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions."1.39Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. ( Abbas, AM; Sakr, HF, 2013)
"Indomethacin ulcers were produced by oral administration of 30 mg/kg bw in the rats pretreated with B-Hb one hour before indomethacin."1.39Gastric antisecretory and antiulcer activity of bovine hemoglobin. ( Al Asmari, AK; Al Asmary, S; Al Malki, A; Al Omani, S; Elfaki, I; Tariq, M, 2013)
"Montelukast is an anti-asthmatic drug, a selective reversible cysteinyl leukotriene D4 receptor antagonist."1.39Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model. ( Cadırcı, E; Ozbakış-Dengiz, G; Yurdakan, G, 2013)
" Long-term use of these drugs is associated with significant gastric injury."1.38Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers. ( Berg, DJ; Buettner, GR; Uc, A; Wagner, BA; Zhu, X, 2012)
"Pretreatment with curcumin caused leukocyte adherence to postcapillary venule to decline (3."1.38Curcumin prevents indomethacin-induced gastropathy in rats. ( Chayanupatkul, M; Choochuai, S; Klaikeaw, N; Patumraj, S; Thong-Ngam, D, 2012)
"Simvastatin treatment activated free radical oxidation, which was seen from enhanced chemiluminescence in the mucosa homogenate (by 1."1.38Effect of HMG-CoA-reductase inhibitor on DNA synthesis and free radical oxidation in the gastric mucosa under normal conditions and during indometacin-induced ulcerative process in the stomach of albino mice. ( Bragina, VV; Fleischman, MY; Lebedko, OA; Sazonova, EN; Timoshin, SS; Zhivotova, EY, 2012)
"Indomethacin (10 mg/kg) was administered orally in fasted or fed rats, and gastrointestinal lesions were examined 24 h after indomethacin administration."1.38Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility. ( Amagase, K; Satoh, H; Takeuchi, K, 2012)
"Pretreatment with candesartan for 10 days reduced significantly the ulcer index induced by indomethacin injection."1.38Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats. ( Awad, AS; El Morsy, EM; Kamel, R, 2012)
"Indomethacin was orally administered to induce an acute gastric injury (3, 10 and 30mg/kg)."1.38Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. ( Castañeda-Hernández, G; Chávez-Piña, AE; Jiménez-Andrade, JM; Pineda-Peña, EA, 2012)
"05), in a dosage range from 4."1.37Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models. ( Badilla, B; García-Barrantes, PM, 2011)
"Risperidone pretreatment reverses the stress induced alteration in hexosamine, PGE(2) and microvascular permeability."1.37Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions. ( Krishnamurthy, S; Saxena, B; Singh, S, 2011)
"Chronic gastric ulcers were induced by serosal application of acetic acid."1.37Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair. ( Chadee, K; Dharmani, P; Srivastava, V; Vong, L; Wallace, JL, 2011)
"Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions."1.37Curative effect of selenium against indomethacin-induced gastric ulcers in rats. ( Kim, BW; Kim, JH; Kwon, HJ; Nam, SW, 2011)
"Paroxetine (1-10 mg/kg) was given orally 30 min before indomethacin."1.37Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats. ( Amagase, K; Gyenge, M; Kojo, A; Nukui, K; Takeuchi, K; Tanaka, A, 2011)
"Gastric ulcers were generated in rats by administration of 70% ethanol, and activity of doxycycline was tested by administration 30 min prior to ethanol."1.37Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress. ( Mishra, A; Saha, D; Singh, LP; Swarnakar, S, 2011)
" Oral administration of IAC dosed at 50 and 100 mg/kg was able to significantly prevent gastric ulceration induced by indomethacin and by stress."1.37Further evidence of the antiulcer activity of IAC, a novel free radical scavenger. ( Baraldi, M; Carnevale, G; Zanoli, P; Zavatti, M, 2011)
"Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e."1.36Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010)
" For these studies, animals were dosed with CP-154,526 (3, 10, 30 mg/kg) and NBI 27914 (1-30 mg/kg) 1 h prior to the assessment of tactile, thermal or mechanical hypersensitivity, respectively."1.36Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. ( Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT, 2010)
" The antiulcerogenic effects of erythropoietin may be related to its intrinsic ability to sustain the activities of free-radical scavenging enzymes and the bioavailability of glutathione."1.36The role of erythropoietin in the protection of gastric mucosa from indometacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats. ( Albayrak, F; Albayrak, Y; Bayir, Y; Dursun, H; Halici, Z; Koc, F; Odabasoglu, F; Polat, B; Suleyman, H; Uyanik, A, 2010)
"Rats treated with indomethacin revealed mucosal hemorrhagic lesions, increased microvascular permeability and inhibited prostaglandin E₂ and mucus content."1.36Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E₂, nitric oxide and redox status in indomethacin-induced gastric ulcer model. ( El-Abhar, HS, 2010)
"The aspirin prodrug ( 23) was a 2."1.35Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies. ( Chen, QH; Citro, ML; Keefer, LK; Knaus, EE; Velázquez, CA, 2008)
"Pretreatment with irsogladine maleate markedly reduced the number and severity of these lesions in a dose-dependent manner."1.35Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats. ( Kageyama, K; Kyoi, T; Tajima, K; Zhang, X, 2008)
"Nicorandil pretreatment depicted a higher preventive index in indomethacin- (89."1.35Gastroprotective effect of nicorandil in indomethacin and alcohol-induced acute ulcers. ( Abdel-Hamid, NM; Abdel-Raheim, SR; El-Moselhy, MA, 2009)
"In indomethacin-treated animals, esomeprazole was more effective than famotidine or the antioxidant melatonin in promoting ulcer healing."1.35Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. ( Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M, 2009)
"Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that is limited in its enteral or parenteral use by side effects of gastroduodenal bleeding and ulceration."1.35Gastrointestinal safety and therapeutic efficacy of parenterally administered phosphatidylcholine-associated indomethacin in rodent model systems. ( Dial, EJ; Lichtenberger, L; Romero, JJ, 2009)
"Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent."1.35Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. ( Albayrak, F; Alp, HH; Bilici, M; Dursun, H; Ozturk, C; Saglam, MB; Suleyman, H, 2009)
"The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)."1.35Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009)
"Indomethacin (IM) is a non-steroidal anti-inflammatory drug which inhibits prostaglandin biosynthesis."1.35Evaluation of gastric toxicity of indomethacin acid, salt form and complexed forms with hydroxypropyl-beta-cyclodextrin on Wistar rats: histopathologic analysis. ( Cabrita, AM; Caramona, MM; Castel-Branco, MM; Figueiredo, IV; Ribeiro-Rama, AC; Veiga, F, 2009)
"Indomethacin treatment was followed by severe injury to the gastric mucosa, decrease in proliferative activity of the epithelium, and stimulation of free-radical processes in gastric tissues."1.35Gastroprotective effect of dalargin in gastropathy due to treatment with nonsteroid antiinflammatory drugs. ( Fleishman, MY; Lebed'ko, OA; Sazonova, EN; Timoshin, SS; Zhivotova, EY, 2009)
" Administration of RBuOH at the same dosage (50, 100 and 200 mg/kg) reduced significantly (P<0."1.35Anti-ulcer, anti-inflammatory and antioxidant activities of the n-butanol fraction from Pteleopsis suberosa stem bark. ( Biasini, T; Braca, A; D'Angelo, V; De Leo, M; De Pasquale, R; Germanò, MP; Miano, TC; Sanogo, R, 2008)
"Gastric ulcers were induced in mice through serosal application of acetic acid."1.35Annexin-1 modulates repair of gastric mucosal injury. ( Flower, RJ; Martin, GR; Perretti, M; Wallace, JL, 2008)
"Acute gastrointestinal hemorrhage from a gastroaortic fistula in the gastric fundoplication pouch is a rare complication of Nissen fundoplication."1.35Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use. ( Depew, WT; Hurlbut, DJ; Manduch, M; Mercer, CD; Rossiter, JP, 2008)
"Indomethacin (IDM) was encapsulated in gelatin-cellulose acetate phthalate (CAP) microcapsules (A) by complex coacervation method and in CAP microcapsules (B) by simple coacervation method."1.34Sustained-release tablets of indomethacin-loaded microcapsules: preparation, in vitro and in vivo characterization. ( He, Y; Lu, B; Wen, R; Yang, H, 2007)
"When ticlopidine was administered 1h after EtOH, it significantly (p<0."1.34Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007)
"Acemetacin was rapidly converted to indomethacin after its administration."1.34Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin. ( Castañeda-Hernández, G; Chávez-Piña, AE; Dicay, M; McKnight, W; Wallace, JL, 2007)
"Spermine and taurine were able to decrease the elevated levels of gastric myeloperoxidase, conjugated diene, and serum NO."1.34Modulation of indomethacin-induced gastric injury by spermine and taurine in rats. ( Abd Elgawad, HM; Motawi, TK; Shahin, NN, 2007)
"Amiodarone is a widely used antiarrhythmic agent."1.34Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats. ( Bayir, Y; Cadirci, E; Dengiz, GO; Halici, Z; Odabasoglu, F; Suleyman, H, 2007)
"In indomethacin and rofecoxib-treated gerbils, the following results were obtained in H pylori-infected group vs H pylori-eradicated group respectively: hyperplasia area of the stomach (mm2): 82."1.33Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils. ( Chang, CC; Chen, SH; Fang, CL; Hsieh, CR; Lien, GS; Lou, HY; Pan, S, 2005)
"Indomethacin treatment dose-dependently reduced survivin protein levels and caused severe injury of gastric mucosa and RGM-1 cells."1.33Survivin: a novel target for indomethacin-induced gastric injury. ( Abdelkarim, B; Akahoshi, T; Chiou, SK; Jones, MK; Tanigawa, T; Tarnawski, AS, 2005)
"Indomethacin is a non-steroidal anti-inflammatory drug but its use is associated with high degree of gastric toxicity therefore it is prescribed only in severe conditions."1.33Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives. ( Amir, M; Kumar, S, 2005)
"Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod."1.33Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005)
"Pre-treatment with pioglitazone dose-dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% (ID50) being 10 mg/kg and 7 mg/kg, respectively."1.33Agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma): a new compound with potent gastroprotective and ulcer healing properties. ( Brzozowski, T; Burnat, G; Cieszkowski, J; Hahn, EG; Konturek, PC; Konturek, S; Kwiecień, SN; Pajdo, R; Pawlik, WW; Targosz, A, 2005)
"Acetic acid ulcers were produced in the rat gastric corpus; non-ulcer rats served as controls."1.33Cell proliferation in the gastric epithelium of the ulcer rat. ( Helander, HF; Li, H, 2005)
"Kolaviron pre-treatment 1 h before ulcer induction attenuated the HCl/ethanol reduction in CAT, SOD and GSH by 43%, 42% and 30%, respectively, and 67%, 68% and 64% following 72 h treatment with kolaviron."1.33Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed. ( Farombi, EO; Olaleye, SB, 2006)
"Gastric ulcer is a source of visceral pain."1.33Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006)
" However, a number of facts involving the occurrence of gastrointestinal lesions have limited the chronic use of NSAIDs."1.32Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine. ( Cardoso, LG; Carvalho, JC; Ferreira, LR; Maciel, HP; Perazzo, FF, 2004)
"Ketoconazole treatment resulted in significant protection against stress; indomethacin and ethanol induced gastric lesions in rats."1.32Protective effect of ketoconazole against experimentally induced gastric ulcers in rats. ( Al Moutaery, AR, 2003)
"Gastric ulcers were induced by abdominal injection of 0."1.31[Synthesis, preliminary antigastrelcosis activity and the protective effect on acute liver injury of zinc chlorin E4]. ( Liu, JF; Lu, JG; Wang, XY; Yao, JZ; Zhang, WN; Zhou, YJ; Zhu, J, 2001)
"Aspirin (500 mg/kg) was given by gavage and repeated 2."1.31Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats. ( Khuri, M; Mourad, FH; Nassar, CF; Shouaib, F, 2000)
" Pharmacodynamic evaluation of the liposomes was performed by carrageenan-induced rat paw edema (acute) and adjuvant arthritis (chronic) models."1.31Preparation and pharmacodynamic evaluation of liposomes of indomethacin. ( Diwan, PV; Srinath, P; Vyas, SP, 2000)
"Ebrotidine is a new H2 receptor antagonist that potentiates the gastric mucosal barrier."1.31Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine. ( Arroyo, MT; Lanas, A; Sáinz, R, 2000)
"Indomethacin has been shown to damage the villous microvasculature concomitant with alterations in villous blood flow in the rat."1.31Endothelial changes precede mucosal ulceration induced by indomethacin: an experimental study in the rat. ( Anthony, A; Kelly, D; Lewin, J; Piasecki, C; Pounder, RE; Wakefield, AJ, 2000)
"The indomethacin treatment of the premedicated animals with the drug hardly affected either the malondialdehyde (MDA) or superoxide dismutase (SOD) level in gastric tissue while the ulcerative agent itself significantly enhanced both the levels."1.31The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. ( Bandyopadhyay, SK; Pakrashi, A; Pakrashi, SC, 2000)
"Pretreatment with indomethacin did not influence the cytoprotective effect of rabeprazole."1.31Cytoprotective effect of rabeprazole against ethanol-induced gastric mucosal damage: possible involvement of nitric oxide. ( Arakawa, T; Fujiwara, Y; Higuchi, K; Tominaga, K; Watanabe, T, 2000)
"Pre-treatment with indomethacin significantly reduced the protective effect of the extract against HCl/ethanol solution to 31%."1.31Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats. ( Dimo, T; Dongo, E; Tan, PV, 2000)
"In vehicle-treated rats, gastric ulcers healed progressively and at day 14 the healing was completed, accompanied by a significant rise in the GBF at ulcer margin."1.31Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. ( Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z, 2001)
"Gastric ulcers were induced by a luminal application of acetic acid in male Donryu rats."1.31Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats. ( Amagase, K; Itoh, S; Nakai, H; Okabe, S; Tsukimi, Y, 2001)
"The effect of hyperprolactinaemia, induced by two or four pituitary homografts under the kidney capsule, on gastric and duodenal ulcers has been studied."1.31Effect of hyperprolactinaemia as induced by pituitary homografts under kidney capsule on gastric and duodenal ulcers in rats. ( Abraham, BK; Asad, M; Balasinor, N; Koumaravelou, K; Ramaswamy, S; Shewade, DG, 2001)
" Gastrointestinal ulceration was assessed, four hours after a single dose and 24 hours following the last dose of a chronic four day dosing regimen, by counting the number of lesions and ulcers present."1.30Comparative evaluation of the severity of gastric ulceration by solid dispersions and coprecipitates of indomethacin. ( Degennaro, MD; Karnachi, AA; Khan, MA; Reddy, IK, 1997)
" Male Sprague-Dawley rats were dosed with two doses of metronidazole (50 mg/kg, 12 and 1 h pre-NSAID) or a single 100 mg/kg dose of tempo 1 h prior to NSAIDs."1.30Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers. ( Davies, NM; Jamali, F, 1997)
"Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20 microliters of 20% acetic acid."1.30[A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump]. ( Katoh, Y; Kawashima, H; Tanaka, M, 1997)
"Pretreatment with glycine significantly protected animals against stress-, indomethacin- and necrotizing agents induced gastric lesions."1.30Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine. ( Al Moutaery, AR; Tariq, M, 1997)
"Pretreatment with indomethacin (10 mg kg[-1], s."1.30Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs. ( Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1997)
"Pretreatment with indomethacin to suppress endogenous PG reversed completely the protective and hyperemic effects of SU-840 against ethanol and stress induced damage whereas L-NNA, a potent inhibitor of NO-synthase, failed to affect protection but completely abolished the hyperemia evoked by this agent."1.30SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity. ( Brzozowski, T; Drozdowicz, D; Konturek, SJ; Kwiecien, S; Muramatsu, M; Pajdo, R; Sliwowski, Z, 1998)
"pretreatment with indomethacin at 5 mg/kg."1.30Protective role of melatonin and the pineal gland in modulating water immersion restraint stress ulcer in rats. ( Arakawa, Y; Asai, S; Ishikawa, K; Iwasaki, A; Kaneda, N; Kato, K; Komuro, S; Kuwayama, H; Matsuno, Y; Murai, I; Nakagawa, S, 1998)
"Indomethacin was administered orally in a dose-dependent manner at 10, 30, and 45 mg/ kg."1.30Naloxone is protective against indomethacin-induced gastric damage in cholestatic rats. ( Amanlou, M; Amanpour, S; Bahadori, M; Dehpour, AR; Mani, AR; Nahavandi, A, 1999)
"Lafutidine is a new type antiulcer agent with antisecretory and gastroprotective activities."1.30Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats. ( Aoyama, M; Arai, Y; Inaba, N; Nishizawa, A; Onodera, S; Sekine, Y; Shibata, M; Suzuki, T; Tanaka, M, 1999)
" CT-3 was devoid of GI ulceration when administered with DMSO either acutely at doses below 100 mg/kg or chronically at a dosage of 30 mg/kg/day for 5 days."1.301',1'-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: a novel, orally effective cannabinoid with analgesic and anti-inflammatory properties. ( Dajani, EZ; Dajani, NE; Dayton, MT; Larsen, KR; Mir, GN; Neeleman, SD; Shahwan, TG; Taylor, J; Taylor, MS, 1999)
"Atropine was given i."1.30Difference between the effect of acute and chronic surgical vagotomy on the cytoprotective action of atropine against indomethacin-induced mucosal lesions on the gastrointestinal tract in rats. ( Bódis, B; Karádi, O; Mózsik, G; Rumi, G; Szabó, I, 1999)
"Treatment with sulpiride (10-320 mg/kg, p."1.29Sulpiride specifically attenuates psychological stress-induced gastric lesions in rodents. ( Kuratani, K; Maeda, N; Nomura, K; Yamaguchi, I, 1995)
"Pretreatment with indomethacin, 10 mg/kg s."1.29Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins. ( Marhuenda, E; Martín, MJ; Pérez Guerrero, C, 1994)
"Naringin-treated rats showed a marked increase in hexosamine levels, but this increase was less in animals pretreated with indomethacin."1.29Antiulcer effect of naringin on gastric lesions induced by ethanol in rats. ( Franco, JM; Marhuenda, E; Martín, MJ; Pérez-Guerrero, C, 1994)
"Misoprostol treatment resulted in a significant reduction in the extent of indomethacin-induced antral ulceration, but ranitidine had no effect."1.29Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer. ( McKnight, GW; Wallace, JL, 1993)
"25 or 0h oral dosing of the 5-lipoxygenase inhibitor, MK-886, but not when only one of these doses was given."1.29Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage. ( Rainsford, KD, 1993)
"Gastric ulcers were produced 5 days after submucosal injection of 20% acetic acid (0."1.29Effect and mechanism of sucralfate on healing of acetic acid-induced gastric ulcers in rats. ( Ogihara, Y; Okabe, S, 1993)
"Indomethacin was associated with a time dependent increase in the extent and severity of ulceration, blood neutrophilia, neutrophil infiltration into the gastric antrum, and calcium ionophore induced immunoreactive leukotriene B4 (LTB4) release from the antrum ex vivo."1.29Do infiltrating neutrophils contribute to the pathogenesis of indomethacin induced ulceration of the rat gastric antrum? ( Clayton, NM; Harman, IW; Strong, P; Trevethick, MA, 1993)
" These results suggested that the bioavailability of IND was increased by olive oil, fatty acid, and tristearin as absorbefacient agents."1.29Pharmacological and pharmaceutical properties of freeze-dried formulations of egg albumin, indomethacin, olive oil, or fatty acids. ( Kakegawa, H; Matsumoto, H; Miyataka, H; Satoh, T; Tsuji, Y, 1993)
"The association between corticosteroid treatment and gastric ulcer healing is controversial."1.29Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers. ( Carpani de Kaski, M; Hodgson, HJ; Levi, S; Rentsch, R, 1995)
" Hourly dosing with hydrochloric acid reversed the protective effect of ranitidine, cimetidine and loxtidine on macroscopic damage and, histologically, this was associated with the widespread appearance of antral ulcers and a reduction in the proportion of mucosal damage caused by superficial erosions."1.29The role of acid in the pathogenesis of indomethacin-induced gastric antral ulcers in the rat. ( Clayton, NM; Oakley, I; Trevethick, MA; Williams, LV, 1996)
"Propranolol pretreatment in the highest dose (10 mg/kg) given either intraperitoneally (i."1.29A study of the antiulcer mechanisms of propranolol in rats. ( Cho, CH; Kaan, SK, 1996)
" The plasma levels of IM after the oral administration of IM-OE and IM-BE were comparatively low compared with those after IM, with a small bioavailability (2."1.29Pharmacokinetics of indomethacin ester prodrugs: gastrointestinal and hepatic toxicity and the hydrolytic capacity of various tissues in rats. ( Iwaki, M; Muraoka, O; Nagai, T; Ogiso, T; Tanabe, G; Tanino, T; Ueda, Y, 1996)
"Pretreatment with indomethacin (5 mg/kg i."1.28Studies on gastroprotection induced by capsaicin and papaverine. ( Brzozowski, T; Drozdowicz, D; Konturek, SJ; Majka, J, 1992)
" Thus, CP-331 exerted anti-inflammatory, analgesic, and antipyretic effects but without showing gastric toxicity, which is a common side effect of anti-inflammatory drugs."1.28Anti-inflammatory, analgesic, and antipyretic effects and gastrointestinal toxicity of the new anti-inflammatory drug N-(3-[3-(piperidinylmethyl)phenoxy]propyl)-carbamoylmethylthio ]ethyl 1-(p-chlorobenzoyl) 5-methoxy-2-methyl-3-indolylacetate. ( Abe, T; Itokazu, Y; Ohya, O; Omata, T; Segawa, Y; Tagashira, E; Tsuzuike, N; Ueda, I; Yoshida, K, 1992)
"Pretreatment with indomethacin (5 mg/kg intraperitoneally), which reduced mucosal generation of PGE2 by 85%, decreased in part the protection by TGF and EGF against ethanol-induced damage and virtually abolished the protective action of these peptides against stress-induced injury."1.28Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. ( Brzozowski, T; Dembinski, A; Konturek, SJ; Majka, J; Slomiany, A; Slomiany, BL, 1992)
"Pretreatment with indomethacin also reversed, in part, the protective and hyperemic effects of sucralfate but the combination of both indomethacin and L-NNA completely abolished these effects."1.28Role of nitric oxide and prostaglandins in sucralfate-induced gastroprotection. ( Brzozowski, T; Czarnobilski, K; Konturek, SJ; Majka, J, 1992)
" The absorption rate from alginate dispersions was enhanced in comparison with that from indomethacin alone, and enhanced only the rate of bioavailability in beagle dogs and volunteers."1.28Improvement of absorption rate of indomethacin and reduction of stomach irritation by alginate dispersions. ( Imai, T; Iwaoka, D; Otagiri, M; Shiraishi, S, 1991)
"Pretreatment with indomethacin significantly mitigated the protective effect of stress against ethanol injury."1.28Gastric mucosal protection induced by restraint and water-immersion stress in rats. ( Ishihara, T; Ohno, T; Uramoto, H, 1990)
"Pretreatment with indomethacin, to suppress mucosal generation of prostaglandins (PG), greatly augmented stress-induced gastric ulcerations and antagonized the protection exerted by both Solcoseryl and EGF."1.28Solcoseryl in prevention of stress-induced gastric lesions and healing of chronic ulcers. ( Bielański, W; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Pytko-Polonczyk, J, 1991)
" The pharmacokinetic profile of indomethacin nanocapsule formulations was compared to a solution of free drug following oral administration of 5 mg/kg in rats; no difference in the mean concentration-time profiles of the drug was observed."1.28Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d,l-lactide) and poly(isobutyl-cyanoacrylate) nanocapsules in rats. ( Ammoury, N; Benita, S; Devissaguet, JP; Dubrasquet, M; Fessi, H, 1991)
"All morphine effects were reversed by naloxone."1.28Antisecretory and anti-ulcer effects of morphine in rats after gastric mucosal aggression. ( Chariot, J; Del Tacca, M; Rozé, C; Tazi-Saad, K; Vatier, J, 1991)
"Aceclofenac is a new phenylacetic acid derivative provided with marked antiinflammatory, antiarthritic, analgesic and antipyretic activities in animal experimental models."1.28The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug. ( Carrasco, E; Felipe, A; Grau, M; Guasch, J; Juliá, S; Montero, JL, 1991)
"5."1.28Relationship between gastric mucosal prostaglandin levels and healing of gastric lesions in rats. ( Goto, H; Kuroiwa, M; Nakazawa, S; Ohara, A; Ozawa, T; Sugiyama, S; Tsukamoto, Y, 1990)
"Indomethacin pretreatment reversed these actions, whereas misoprostol administration produced the similar effects as 20% ethanol."1.28Endogenous prostaglandins: its role in gastric mucosal blood flow and ethanol ulceration in rats. ( Chen, BW; Cho, CH; Hui, WM; Lam, SK; Luk, CT, 1990)
"Treatment with dipyridamole replenish the reduced level of gastric mucosal nonprotein sulfhydryls, thus suggesting the mediation of its protective effect through sulfhydryls."1.28Gastric antiulcer and cytoprotective effects of dipyridamole in rats. ( Ageel, AM; Tariq, M, 1990)
"Indomethacin pretreatment did not significantly alter any of these findings."1.28Microscopic correlates of adaptive cytoprotection in an ethanol injury model. ( Miller, TA; Schmidt, KL; Smith, GS, 1989)
"Indomethacin is a potent and efficacious antiinflammatory agent."1.28Influence of indomethacin amphoteric gel on gastric ulcerogenicity and absorption of indomethacin in rats. ( Dent, J; Eickhoff, WM; Liversidge, GG, 1989)
"Pretreatment with ebselen at oral doses from 10 to 100 mg/kg significantly inhibited such lesion formation induced by either necrotizing agent in a dose-related manner, and the inhibition at the highest dose (100 mg/kg p."1.28Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats. ( Akasaki, M; Kurebayashi, Y; Tabuchi, Y, 1989)
"Gastric ulcers were induced by the submucosal injection of 20% acetic acid (0."1.28Effects of NC-1300, a gastric proton pump inhibitor, on healing of acetic acid-induced gastric ulcers in rats. ( Miyake, H; Okabe, S; Yamasaki, S, 1989)
" An increase in malondialdehyde level was observed after ethanol exposure, whereas suppression of lipid peroxidation occurred after dosing with indomethacin."1.28Lipid peroxidation in normal and ulcerated gastric mucosa of rats treated with pentacaine and cimetidine. ( Nosál, R; Nosálová, V; Petríková, M, 1989)
"Pretreatment with indomethacin (IND) had little influence on the cytoprotective effects of OGT and glutathione, but attenuated the effect of sucralfate."1.28A possible mechanism for the gastric mucosal protection by oren-gedoku-to (OGT), a traditional herbal medicine. ( Imanishi, K; Miura, O; Takase, H; Yumioka, E, 1989)
") given 30 min prior to SU-88 dosing blocked this protective effect, whereas it was not affected when indomethacin was given 30 min after the SU-88 dosing."1.27Cytoprotective effect of SU-88, an anti-ulcer agent, in the rat. ( Kyogoku, K; Mori, Y; Nakazima, M; Shinozaki, A; Suwa, T, 1984)
" Moreover the gastric lesions in FCE 20700 + I treated rats were markedly reduced, allowing the dosage of I to be increased by about three times without increasing its ulcerogenic effect."1.27FCE 20700, a cytoprotective PGE2 derivative, does not interfere with the antiinflammatory activity of indomethacin. ( Arrigoni, C; Buttinoni, A; Ceserani, R; Ferrari, M; Mizzotti, B; Tremolada, L, 1983)
"If indomethacin was given intravenously either before or immediately after the first ethanol exposure, recovery of barrier function was significantly lessened after this challenge, and the resistance to barrier disruption was significantly decreased during the two subsequent exposures to ethanol when compared to experiments in which mucosa was exposed to 20% ethanol without concomitant administration of indomethacin."1.27Indomethacin decreases resistance of gastric barrier to disruption by alcohol. ( Henagan, JM; Miller, TA, 1984)
"aspirin were additive."1.27Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent. ( Holsapple, MP; Nichols, DE; Trizzino, J; Yim, GK, 1983)
"Indomethacin pretreatment (20 mg/kg, p."1.27Sulphasalazine and experimental stress ulcers. ( Cho, CH; Dai, S; Ogle, CW, 1985)
"Pretreatment with indomethacin (8 mg/kg intraperitoneally) abolished the effects of the 10% linoleic acid diet on prostaglandin formation, acid secretion, and mucosal injury."1.27Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: effects on gastric acid secretion and stress-induced mucosal damage. ( Classen, M; Ruoff, HJ; Schepp, W; Schusdziarra, V; Steffen, B, 1988)
"Indomethacin pretreatment (10 mg/kg p."1.27Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions. ( Barnett, A; Brown, AD; Chiu, PJ; Gerhart, C; Siegel, M, 1988)
"Morphine has been shown to produce a significant potentiation of indomethacin-induced gastric lesions in rats."1.27Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1987)
"Pretreatment with indomethacin partially reduced the protective effect of sucralfate."1.27Role of mucus and prostaglandins in the gastric mucosal protective actions of sucralfate against ethanol-induced injury in the rat. ( Quadros, E; Ramsamooj, E; Wilson, DE, 1987)
"Cimetidine, which was used as a standard antiulcer drug for comparison, also produced a similar protective effect in most of the models used by us."1.27Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1987)
" Oral dosing with U46619 or AH23848 produced a dose-related inhibition of ethanol-induced gastric mucosal damage in the conscious rat, and these effects were partially blocked by indomethacin treatment."1.27The effects of the stable thromboxane A2-mimetic, U46619, on gastric mucosal damage and gastric non-parietal secretion in the rat. ( Bunce, KT; Clayton, NM, 1987)
"Indomethacin co-treatment attenuated the reduction of ulcer formation of both pretreatments."1.27Evidence of "cross-stressor"-induced adaptive gastric cytoprotection. ( Glavin, GB; Hall, AM; Kiernan, KM; Lockhart, LK; Rockman, GE, 1987)
"Indomethacin pretreatment did not significantly augment the duodenal lesions induced by mepirizole or cysteamine, but did augment the gastric lesions induced by these compounds."1.27Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin. ( Kuwahara, Y; Okabe, S; Tanaka, H, 1986)
"Marked gastric ulcers were induced by indomethacin and diclofenac, and severe intestinal ulcers were also produced at 24 h and by their repeated administration."1.27Ulcerogenic and antiulcerogenic effects of a new antiinflammatory drug, the gamma-lactone-N-ethyl derivative of 6-[1S-(3S,4-dihydro-8-hydroxy-1H-2-benzo- pyran-1-one-3-yl)-3-methylbutylamino]-4S,5S-dihydroxy-6-oxo-3S- ammoniohexanoate, on gastrointestinal ( Kasuya, Y; Urushidani, T; Yano, S, 1986)
"pretreatment with indomethacin (5 mg/kg, s."1.27Cytoprotective effects of NC-1300 and omeprazole on Hcl . ethanol-induced gastric lesions in rats. ( Awane, Y; Miyake, H; Okabe, S, 1986)
"Salicylic acid has been shown to decrease gastric mucosal lesions induced by indomethacin in the rat."1.27Salicylic acid blocks indomethacin-induced cyclooxygenase inhibition and lesion formation in rat gastric mucosa. ( Elashoff, J; Guth, PH; Hansen, D; Kauffman, GL; Ligumsky, M; Paulsen, G, 1985)
"indomethacin) have been explored as a means for reducing the gastric ulcerogenicity of the latter."1.27Structural damage and changes in eicosanoid metabolites in the gastric mucosa of rats and pigs induced by anti-inflammatory drugs of varying ulcerogenicity. ( Rainsford, KD, 1986)
"Indomethacin pretreatment antagonized sodium benzoate-ulcer reducing properties indicating that this latter acts, at least in part, through stimulation of prostaglandins synthesis."1.27Influence of antioxidants and radical scavengers on ethanol-induced gastric ulcers in the rat. ( Evangelista, S; Meli, A, 1985)
"possessed useful properties in the treatment of gastric ulcers."1.27Experimental anti-ulcer activity of Veronica officinalis L. extracts. ( Cuparencu, B; Sandor, V; Scarlat, M; Tămaş, M, 1985)
"Nabumetone is a compound of novel structure which displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs."1.26Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent. ( Boyle, EA; Freeman, PC; Mangan, FR; Thomson, MJ, 1982)
" Indomethacin--in the same test--was 37 times more potent than A-162-ester and the PGI2 inhibition and ulcerogenic dose-response curves for indomethacin were parallel."1.26A new anti-inflammatory derivative of imidazole which is less ulcerogenic than indomethacin in rats. ( Corell, T; Jensen, KM; Splawinski, J, 1979)
" The degree of gastric or intestinal irritation seen with dosing of other drugs was as follows; indomethacin greater than diclofenac Na greater than ibuprofen greater than aspirin greater than phenylbutazone or indomethacin greater than CH-800 = diclofenac Na greater than ibuprofen greater than phenylbutazone, respectively."1.26[Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)]. ( Ohtsuki, H; Okabe, S; Tabata, K, 1979)
" In animals pretreated by anti-inflammatory drugs in toxic doses an earlier development of ulceration was observed by distention with acid."1.26Distention ulcer as a model for testing of drugs for ulcerogenic side effects. ( Szelenyi, I; Thiemer, K, 1978)

Research

Studies (1,200)

TimeframeStudies, this research(%)All Research%
pre-1990329 (27.42)18.7374
1990's279 (23.25)18.2507
2000's269 (22.42)29.6817
2010's250 (20.83)24.3611
2020's73 (6.08)2.80

Authors

AuthorsStudies
Ackrell, J1
Antonio, Y1
Franco, F1
Landeros, R1
Leon, A1
Muchowski, JM1
Maddox, ML1
Nelson, PH1
Rooks, WH1
Roszkowski, AP1
Wallach, MB1
Nagakura, M1
Ota, T1
Shimidzu, N1
Kawamura, K1
Eto, Y1
Wada, Y1
Yoshioka, Y1
Kitagawa, M1
Oki, M1
Kubo, S2
Tagawa, H2
Ueno, K2
Tsukada, W2
Tsubokawa, M1
Kasahara, A1
Yoshioka, T1
Asselin, AA1
Humber, LG2
Dobson, TA1
Komlossy, J1
Martel, RR1
Demerson, CA1
Philipp, AH1
Safak, C1
Erdogan, H1
Palaska, E1
Sunal, R1
Duru, S1
Ikuta, H2
Shirota, H2
Kobayashi, S2
Yamagishi, Y3
Yamada, K3
Yamatsu, I2
Katayama, K2
Toja, E1
Selva, D3
Schiatti, P3
Nagai, Y1
Irie, A1
Nakamura, H4
Hino, K1
Uno, H1
Nishimura, H1
Closse, A1
Haefliger, W1
Hauser, D1
Gubler, HU1
Dewald, B1
Baggiolini, M1
Paris, GY1
Garmaise, DL1
Cimon, DG1
Swett, L1
Carter, GW1
Young, P1
Anderson, NG1
Carson, JR1
Song, Y3
Connor, DT2
Doubleday, R2
Sorenson, RJ2
Sercel, AD2
Unangst, PC2
Roth, BD2
Gilbertsen, RB3
Chan, K3
Schrier, DJ2
Guglietta, A4
Bornemeier, DA2
Dyer, RD3
Beylin, VG1
Shin, SS1
Byun, Y1
Lim, KM1
Choi, JK1
Lee, KW2
Moh, JH1
Kim, JK1
Jeong, YS1
Kim, JY1
Choi, YH4
Koh, HJ1
Park, YH2
Oh, YI1
Noh, MS1
Chung, S1
Velázquez, C2
Praveen Rao, PN2
Knaus, EE4
Metwally, KA1
Yaseen, SH1
Lashine, el-SM1
El-Fayomi, HM1
El-Sadek, ME1
Zheng, X1
Oda, H1
Takamatsu, K1
Sugimoto, Y1
Tai, A1
Akaho, E1
Ali, HI1
Oshiki, T1
Kakuta, H1
Sasaki, K1
Tozkoparan, B2
Küpeli, E2
Yeşilada, E3
Ertan, M2
Rosati, O1
Curini, M1
Marcotullio, MC1
Macchiarulo, A1
Perfumi, M1
Mattioli, L1
Rismondo, F1
Cravotto, G1
Velázquez, CA3
Citro, ML2
Keefer, LK2
Wey, SJ1
Augustyniak, ME1
Cochran, ED1
Ellis, JL1
Fang, X1
Garvey, DS1
Janero, DR1
Letts, LG1
Martino, AM1
Melim, TL1
Murty, MG1
Richardson, SK1
Schroeder, JD1
Selig, WM1
Trocha, AM1
Wexler, RS1
Young, DV1
Zemtseva, IS1
Zifcak, BM1
Szabó, G2
Fischer, J1
Kis-Varga, A1
Gyires, K5
Chen, QH1
Abdel-Megeed, AM1
Abdel-Rahman, HM1
Alkaramany, GE1
El-Gendy, MA1
Shoman, ME2
Abdel-Aziz, M4
Aly, OM2
Farag, HH1
Morsy, MA6
Laddha, SS1
Bhatnagar, SP1
Huang, Z1
Abdellatif, KR1
Chowdhury, MA1
Reisz, JA1
DuMond, JF1
King, SB2
Bandgar, BP1
Sarangdhar, RJ1
Viswakarma, S1
Ahamed, FA1
Manivannan, E1
Chaturvedi, SC1
Bali, A2
Ohri, R1
Deb, PK1
Abuo-Rahma, Gel-D2
Beshr, EA2
Ali, TF1
Abdel-Rahman, IM1
Ozadali, K1
Tan, OU1
Farag, NA1
Kaoud, TS1
Ali, Y2
Alam, MS2
Hamid, H2
Husain, A2
Bano, S2
Dhulap, A2
Kharbanda, C2
Nazreen, S1
Haider, S1
Naumov, RN1
Panda, SS1
Girgis, AS1
George, RF1
Farhat, M1
Katritzky, AR1
Parra, T1
Benites, J1
Ruiz, LM1
Sepulveda, B2
Simirgiotis, M2
Areche, C2
Banerjee, AG1
Das, N1
Shengule, SA1
Srivastava, RS1
Shrivastava, SK1
Quispe, C1
Torres-Benítez, A1
Reyes-Ortíz, J1
García-Beltrán, O1
Singh, J4
Saini, V1
Kumar, A2
Bansal, R1
Sharma, R1
Chaudhari, BB1
Navarro, L1
Rosell, G1
Sánchez, S1
Boixareu, N1
Pors, K1
Pouplana, R1
Campanera, JM1
Pujol, MD1
Ahmed, EM1
Kassab, AE2
El-Malah, AA1
Hassan, MSA1
Gedawy, EM1
El Kerdawy, AM1
Saiki, R2
Yoshimi, T2
Kudo, T2
Ito, K2
Ma, N1
Sun, Y1
Yi, J1
Zhou, L1
Cai, S1
Fagundes, FL1
Pereira, QC1
Zarricueta, ML1
Dos Santos, RC1
Aleid, IS1
Alfheeaid, HA1
Aljutaily, T1
Alhomaid, RM1
Alharbi, HF1
Althwab, SA1
Abdel-Rahman, HA1
AlGeffari, MA1
Barakat, H1
Sallam, AM1
Darwish, SF1
El-Dakroury, WA1
Radwan, E1
Jindal, A1
Singh, R1
Tomar, S1
Dureja, J1
Karan, M1
Chadha, R1
Küçükler, S1
Kandemir, FM1
Yıldırım, S2
Choudhary, P1
Roy, T1
Chatterjee, A5
Mishra, VK1
Pant, S1
Swarnakar, S10
Jafari, A1
Andishfar, N1
Esmaeilzadeh, Z1
Khezri, MR1
Ghasemnejad-Berenji, M1
Mohamed, YT1
Naguib, IA1
Abo-Saif, AA1
Elkomy, MH1
Alghamdi, BS1
Mohamed, WR1
Balaha, MF2
Almalki, ZS1
Alahmari, AK1
Ahmed, NJ1
Khalaf, HM1
Ahmed, SM1
Welson, NN1
Abdelzaher, WY1
Toktay, E1
Yayla, M2
Sahin, L1
Harmankaya, A1
Ozic, C1
Aksu Kilicle, P1
Gurbuz, MA1
Erbas, E1
Demir, O1
Bayram, P1
Salinas-Nolasco, C1
Barragán-Zarate, GS1
Lagunez-Rivera, L1
Solano, R1
Favari, L1
Jiménez-Andrade, JM2
Chávez-Piña, AE4
İpek, BE1
Yüksel, M3
Cumbul, A1
Ercan, F1
Cabadak, H1
Aydın, B1
Alican, İ2
Abd-Eldayem, AM1
Alnasser, SM1
Abd-Elhafeez, HH1
Soliman, SA1
Abdel-Emam, RA1
Bao, T2
Feng, L2
Cho, S1
Yu, H1
Jin, W1
Dai, L1
Zhang, J4
Bai, L2
Fu, M2
Chen, Y2
Bawakid, NO1
Alorfi, HS1
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Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase 2 Study of Orally Administrated JBM-TC4 for the Prevention of Acute Radiation-induced Dermatitis in Breast Cancer Patients[NCT02289365]Phase 2120 participants (Actual)Interventional2014-11-30Enrolling by invitation
Effects of Lavender Aromatherapy and Cold Application on Pain During Drain Removal[NCT04798040]121 participants (Actual)Interventional2021-09-01Completed
Elderly Patients With Dementia in the Department of Acute Geriatrics: Pilot Study, Monocentric, Randomized Use of Aromatherapy as a Complementary Treatment to Psychopharmacotherapy in Psychological Disorders and BPSD Behavior[NCT03662360]32 participants (Actual)Interventional2018-05-20Completed
A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients[NCT01837966]93 participants (Actual)Interventional2013-01-31Completed
Rebamipide Ophthalmic Suspension in the Treatment of Dry Eye: A Multicenter, Phase 3, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, 52 Week Study[NCT00201981]Phase 3740 participants (Anticipated)Interventional2004-05-31Completed
Efficacy of Zinc L-carnosine (Hepilor®) in Maintaining Remission of Gastroesophageal Reflux Disease: a Randomised, Double-blind, Placebo-controlled Study[NCT03467438]Phase 480 participants (Anticipated)Interventional2018-11-22Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Role of Essential Oil Therapy in Environmental Diffusion as a Complement of Psychotropic Drugs in the Management of Psychological and Behavioral Disorders (BPSD)

"The Neuropsychiatric Inventory - Nursing Home Version (NPI-NH) test will characterize the neuropsychiatric and psychopathological symptoms of patients affected by dementia.~Events as delirium, anxiety, depression, etc. will be recorded by the frequency (from 0, absence, to 4, high frequency) and the seriousness (from 0, absence, to 3, high). The total score of the NPI-NH is given by the frequency x (multiply) seriousness (total score for each event has a range from 0 to 12). The patient final score will be given by the sum of the score of the 12 events. For each patient will be given a total score from 0 to 144.~NPI NH score has been collected in both control and aromatherapy groups at T1 and T3, in patients who needed and who did not needed Pro Re Nata." (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)

,
Interventionscore on a scale (Mean)
T1 NPI score in patients do not need Pro Re NataT3 NPI score in patients needed Pro Re NataT3 NPI score in patients do not need Pro Re Nata
GROUP A - Control Group21.8132.8720.00
GROUP B - Aromatherapy Group25.9316.57.25

Role of Essential Oil Therapy in Environmental Diffusion in Professional Caregiver Distress Linked to BPSD

NPI-NH assess the psychological distress in physicians, nurses and nursing assistants who managed the patients. It has a score from 0 (no discomfort) to score of 5 (extreme discomfort). The psychological distress is measured for each of the 12 events in the NPI-NH scale, for a total score from 0 to 60. (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)

,
Interventionscore on a scale (Mean)
T1 NPI NH physicians in pts with PRNT1 NPI NH physicians in pts without PRNT1 NPI NH nurses in pts with PRNT1 NPI NH nurses in pts without PRNT1 NPI NH nursing assistants in pts with PRNT1 NPI NH nursing assistants in pts without PRNT3 NPI NH physician in pts with PRNT3 NPI NH physician in pts without PRNT3 NPI NH nurses in pts with PRNT3 NPI NH nurses in pts without PRNT3 NPI NH nursing assistants in pts with PRNT3 NPI NH nursing assistants in pts without PRN
GROUP A - Control Group4.191.609.636.4011.007.106.003.2012.009.3013.199.90
GROUP B - Aromatherapy Group5.644.1311.6410.1312.2110.882.640.885.794.255.934.38

Anxiety Reduction

We hoped to show that lavender aroma therapy reduces preoperative anxiety in patients undergoing breast. The Trait subscale (STAI-TRAID) of the Spielberger State-Trait Anxiety Inventory was administered before and after 10 minutes of aromatherapy treatment pre-surgery. The TRAIT subscale contains 20 questions scored on a Likert scale from 1-4; item scores are summed for a total score ranging from 20 to 80, with higher scores indicating higher anxiety. Change in anxiety was calculated as the score pre-aromatherapy minus the score post-aromatherapy. Higher positive change scores indicate greater reductions in anxiety. (NCT01837966)
Timeframe: 20 minutes before surgery (pre aromatherapy) and 10 minutes before surgery (post aromatherapy)

Interventionunits on a scale (Mean)
Lavender Oil0.89
Placebo.74

Reviews

17 reviews available for indomethacin and Stomach Ulcer

ArticleYear
Gastroprotective Role of Fruit Extracts in Gastric Damage Induced by Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review.
    Journal of medicinal food, 2023, Volume: 26, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Fruit; G

2023
[Free Radical Production and Production Mechanism in the Early and Advanced Stages of Gastrointestinal Lesions].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2020, Volume: 140, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dextran Sulfate; Electron Spin Resonance

2020
[Gastroprotective role of glucocorticoid hormones during action of nonsteroidal anti-inflammatory drugs].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2009, Volume: 95, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Gastric Mucosa; Glucocorticoids; Hu

2009
Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers.
    Inflammation, 2010, Volume: 33, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bicarbonates; Cyclooxygenase In

2010
[Novel pharmacological effects of NSAIDs and their molecular mechanism].
    Seikagaku. The Journal of Japanese Biochemical Society, 2012, Volume: 84, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag

2012
[Changes in ulcerogenic response to non-steroidal antiinflammatory drugs (NSAIDs) in the gastrointestine during chronic arthritis].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2006, Volume: 128, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cy

2006
Compensatory gastroprotective role of glucocorticoid hormones during inhibition of prostaglandin and nitric oxide production and desensitization of capsaicin-sensitive sensory neurons.
    Inflammopharmacology, 2007, Volume: 15, Issue:4

    Topics: Adrenalectomy; Animals; Capsaicin; Corticosterone; Gastric Mucosa; Glucocorticoids; Indomethacin; Ne

2007
Drug therapy: nonsteroidal antiinflammatory drugs (first of two parts).
    The New England journal of medicine, 1980, May-22, Volume: 302, Issue:21

    Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Child; Drug Tolerance; Female; Gastric Mucosa; Gastrit

1980
Non-steroidal anti-inflammatory drug-induced gastric damage in experimental animals: underlying pathological mechanisms.
    General pharmacology, 1995, Volume: 26, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cricetinae; Gastric Acid; Histamine H2 Antagonists

1995
Selective cyclooxygenase-2 inhibitors as potential therapeutic agents for inflammatory diseases.
    Advances in experimental medicine and biology, 1997, Volume: 407

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2

1997
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:4

    Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer

2001
Role of cyclooxygenase-2 in gastric mucosal defense.
    Life sciences, 2001, Nov-09, Volume: 69, Issue:25-26

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;

2001
[Mechanism of the ulcerogenic effects of phenylbutazone and indomethacin].
    Ceskoslovenska gastroenterologie a vyziva, 1978, Volume: 32, Issue:8

    Topics: Adrenalectomy; Animals; Female; Gastric Juice; Gastric Mucosa; Guinea Pigs; Histidine Decarboxylase;

1978
The role of the mucosal barrier in drug-induced gastric ulceration and erosions.
    The American journal of digestive diseases, 1976, Volume: 21, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ethanol; Gastric Juice; Gastric Mucosa;

1976
Analgesics and the stomach.
    The New Zealand medical journal, 1976, Aug-11, Volume: 84, Issue:569

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Indometha

1976
[Effect of some drugs in the development and exacerbation of gastric and duodenal ulcer].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1974, Jun-15, Volume: 27, Issue:12

    Topics: Adrenocorticotropic Hormone; Aspirin; Caffeine; Catecholamines; Duodenal Ulcer; Fluorouracil; Glucoc

1974
[Effect of some antirheumatic agents on the gastric mucous membrane].
    Klinicheskaia meditsina, 1971, Volume: 49, Issue:8

    Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma

1971

Trials

12 trials available for indomethacin and Stomach Ulcer

ArticleYear
Gastroprotective effect of topiramate on indomethacin-induced peptic ulcer in rats: Biochemical and histological analyses.
    Basic & clinical pharmacology & toxicology, 2022, Volume: 130, Issue:5

    Topics: Animals; Antioxidants; Indomethacin; Ranitidine; Rats; Stomach Ulcer; Superoxide Dismutase; Topirama

2022
Gastric microbleeding measurements during one day treatment with indomethacin and indomethacin plus sodium salicylate (1 : 10) in patients.
    Acta physiologica Hungarica, 1984, Volume: 64, Issue:3-4

    Topics: Adult; Double-Blind Method; Drug Combinations; Female; Gastric Juice; Gastric Mucosa; Hemoglobinomet

1984
Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation.
    The American journal of medicine, 1983, Oct-31, Volume: 75, Issue:4B

    Topics: Adult; Anti-Inflammatory Agents; Capsules; Drug Evaluation; Female; Gastric Mucosa; Gastrointestinal

1983
Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients.
    Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:10

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheu

1993
Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration.
    Gut, 1997, Volume: 40, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cimetidine; Cross-Over S

1997
Studies on the protective effect of ebrotidine on experimental ulcers induced by non-steroidal anti-inflammatory drugs in healthy volunteers.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:4A

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Carbonic Anhydrases; Female

1997
Reduction of non-steroidal anti-inflammatory drug induced gastric injury and leucocyte endothelial adhesion by octreotide.
    Gut, 1997, Volume: 40, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Double-Blind Method; Endothelium, V

1997
Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study.
    Digestive diseases and sciences, 1998, Volume: 43, Issue:9 Suppl

    Topics: Adult; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytokines;

1998
[Therapy of gastric and duodenal ulcer with Metoclopramide].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1976, Apr-30, Volume: 52, Issue:12

    Topics: Aged; Clinical Trials as Topic; Duodenal Ulcer; Female; Humans; Indomethacin; Male; Metoclopramide;

1976
A comparison of upper gastrointestinal mucosal damage by standard and delayed-release indomethacin.
    Alimentary pharmacology & therapeutics, 1992, Volume: 6, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Double-Blind Method; Duodenal Ulcer; Du

1992
Prevention of non-steroidal anti-inflammatory agents induced acute gastric mucosal lesions by carbonic anhydrase inhibitors. An endoscopic study.
    Acta physiologica Hungarica, 1989, Volume: 73, Issue:2-3

    Topics: Acetazolamide; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastroscopy;

1989
[Stomach tolerance of nonsteroidal antirheumatic drugs: comparative endoscopic study].
    Zeitschrift fur Rheumatologie, 1987, Volume: 46 Suppl 1

    Topics: Adult; Alprostadil; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspiri

1987

Other Studies

1171 other studies available for indomethacin and Stomach Ulcer

ArticleYear
Synthesis and antiinflammatory activity of 6,11-dihydro-11-oxodibenzo[b,e]thiepinalkanoic acids and related compounds.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:10

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exp

1978
Syntheses and antiinflammatory actions of 4,5,6,7-tetrahydroindazole-5-carboxylic acids.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Edema; Indazole

1979
Nonsteroidal antiinflammatory agents. 2. Derivatives/analogues of dibenz[b,e]oxepin-3-acetic acid.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dibenzoxepins; Edema; Lethal Dose 50; Male; Rats; St

1978
6,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:7

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dibenzoxepins; Edema; Female; Le

1976
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes;

1976
Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent di- and trisubstituted 1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acids.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Freund's Adjuvant; Indoleacet

1976
Synthesis of 3-(2-pyridylethyl)benzoxazolinone derivatives: potent analgesic and antiinflammatory compounds inhibiting prostaglandin E2.
    Journal of medicinal chemistry, 1992, Apr-03, Volume: 35, Issue:7

    Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A

1992
Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylidene Compounds; Cyclooxygenase Inhibitors;

1987
3-Alkyl-2-aryl-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Evaluation, Preclini

1984
Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, E

1982
2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzofurans; Cattle; Chemical Phenomena;

1981
Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides).
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:1

    Topics: Animals; Arthritis, Experimental; Edema; Glycerides; Indomethacin; Male; Rats; Stomach Ulcer; Struct

1980
Synthesis and biological activity of 5-(4-chlorobenzoyl)-4-(hydroxymethyl)-1-methyl-1H-pyrrole-2-acetic acid, a major metabolite of zomepirac sodium.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:1

    Topics: Analgesics; Animals; Arthritis, Experimental; Humans; In Vitro Techniques; Platelet Aggregation; Pyr

1980
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
    Journal of medicinal chemistry, 1999, Apr-08, Volume: 42, Issue:7

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cycl

1999
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
    Journal of medicinal chemistry, 1999, Apr-08, Volume: 42, Issue:7

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan

1999
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
    Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4

    Topics: Adult; Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge

2004
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
    Journal of medicinal chemistry, 2005, Jun-16, Volume: 48, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azo Compounds; Cyclooxygenase 1; Cyclooxy

2005
Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Male; Naproxen; Propionat

2007
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.
    Bioorganic & medicinal chemistry, 2007, Jan-15, Volume: 15, Issue:2

    Topics: Analgesics; Anilides; Animals; Benzenesulfonates; Carrageenan; Colorimetry; Crystallography, X-Ray;

2007
Preparation of 5-aryl-3-alkylthio-l,2,4-triazoles and corresponding sulfones with antiinflammatory-analgesic activity.
    Bioorganic & medicinal chemistry, 2007, Feb-15, Volume: 15, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Mice; Molecular Structure; Stomach Ulcer; Sulfones; T

2007
Synthesis, docking studies and anti-inflammatory activity of 4,5,6,7-tetrahydro-2H-indazole derivatives.
    Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena

2007
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.
    Bioorganic & medicinal chemistry, 2007, Jul-15, Volume: 15, Issue:14

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cycloo

2007
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
    Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25

    Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Synergism; Female; Gastr

2007
New celecoxib derivatives as anti-inflammatory agents.
    Journal of medicinal chemistry, 2008, Jan-10, Volume: 51, Issue:1

    Topics: Acetic Acid; Animals; Carrageenan; Celecoxib; Chronic Disease; Crystallization; Cyclooxygenase 1; Cy

2008
Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
    Journal of medicinal chemistry, 2008, Mar-27, Volume: 51, Issue:6

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azo Compounds; Carr

2008
Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:1

    Topics: Acetates; Acylation; Animals; Anti-Inflammatory Agents; Drug Design; Drug-Related Side Effects and A

2009
Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Edema; Indomethacin; Male; Nitric Oxide; Pyrazoles; Rats; Referen

2009
A new therapeutic approach in Parkinson's disease: some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Animals; Anti-Inflammatory Agents; Child, Preschool; Cyclic Nucleotide Phosphodiesterases, Type 1; D

2009
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
    Journal of medicinal chemistry, 2011, Mar-10, Volume: 54, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Edema; Est

2011
Synthesis and biological evaluation of orally active prodrugs of indomethacin.
    Journal of medicinal chemistry, 2011, Mar-10, Volume: 54, Issue:5

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Stability;

2011
Analogue-based design, synthesis and molecular docking analysis of 2,3-diaryl quinazolinones as non-ulcerogenic anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2011, Aug-01, Volume: 19, Issue:15

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase I

2011
Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents.
    European journal of medicinal chemistry, 2012, Volume: 49

    Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Edema; Models, Mole

2012
1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities.
    European journal of medicinal chemistry, 2014, Volume: 71

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Edem

2014
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.
    European journal of medicinal chemistry, 2014, Apr-22, Volume: 77

    Topics: Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxyg

2014
Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.
    European journal of medicinal chemistry, 2014, Aug-18, Volume: 83

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclooxygenase 2;

2014
Design, synthesis and biological evaluation of piperic acid triazolyl derivatives as potent anti-inflammatory agents.
    European journal of medicinal chemistry, 2015, Mar-06, Volume: 92

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Line; Cell Sur

2015
Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates.
    Bioorganic & medicinal chemistry letters, 2015, Jun-01, Volume: 25, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Indomethacin; Mesalamine; Metronidazole; Mice; Molecular Structur

2015
Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls.
    Bioorganic & medicinal chemistry letters, 2015, Jul-15, Volume: 25, Issue:14

    Topics: Abietanes; Animals; Anti-Ulcer Agents; Baccharis; Cell Line; Cell Survival; Gastric Juice; Gastric M

2015
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
    European journal of medicinal chemistry, 2015, Aug-28, Volume: 101

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cycloox

2015
Gastroprotective activity of synthetic coumarins: Role of endogenous prostaglandins, nitric oxide, non-protein sulfhydryls and vanilloid receptors.
    Bioorganic & medicinal chemistry letters, 2016, 12-01, Volume: 26, Issue:23

    Topics: Animals; Anti-Ulcer Agents; Coumarins; Gastric Mucosa; Mice; Nitric Oxide; Prostaglandins; Stomach U

2016
Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening.
    Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Anti-Inflammatory Agents; Drug Design; Rats; Rats, Wistar;

2017
Synthesis, molecular docking and biological evaluation of some newer 2-substituted-4-(benzo[d][1,3]dioxol-5-yl)-6-phenylpyridazin-3(2H)-ones as potential anti-inflammatory and analgesic agents.
    Bioorganic chemistry, 2017, Volume: 71

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Cyclooxy

2017
Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
    Bioorganic & medicinal chemistry letters, 2017, 07-01, Volume: 27, Issue:13

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Benzimidazoles; C

2017
Synthesis and biological properties of aryl methyl sulfones.
    Bioorganic & medicinal chemistry, 2018, 08-07, Volume: 26, Issue:14

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimet

2018
Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents.
    European journal of medicinal chemistry, 2019, Jun-01, Volume: 171

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In

2019
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.
    European journal of medicinal chemistry, 2020, Mar-01, Volume: 189

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonate 5-Lipoxygenase; Cyclo

2020
Gastroprotective Effect of Enteral Nutrition Formula in Mice Injected Subcutaneously with Indomethacin.
    Nutrients, 2021, Sep-21, Volume: 13, Issue:9

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Enteral Nutrition; Food, For

2021
Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis.
    Journal of ethnopharmacology, 2022, Feb-10, Volume: 284

    Topics: Animals; Animals, Outbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apopt

2022
Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation.
    Nutrients, 2021, Sep-23, Volume: 13, Issue:10

    Topics: Acetic Acid; Animals; Anthocyanins; Antioxidants; Biomarkers; Cyclooxygenase 1; Disease Models, Anim

2021
Gastroprotective Effects of
    Nutrients, 2021, Oct-03, Volume: 13, Issue:10

    Topics: Actinidia; Animals; Anti-Ulcer Agents; Disease Models, Animal; Fruit; Gastric Mucosa; Indomethacin;

2021
Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway.
    Pharmaceutical research, 2021, Volume: 38, Issue:11

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biologica

2021
Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies.
    Pharmaceutical research, 2021, Volume: 38, Issue:12

    Topics: Alanine; Animals; Biological Availability; Biological Products; Carrageenan; Chemical Engineering; C

2021
Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2022, Volume: 97, Issue:7

    Topics: Animals; Antioxidants; Arginase; bcl-2-Associated X Protein; Caspase 3; Cyclooxygenase 2; Flavonoids

2022
Melatonin rescues swim stress induced gastric ulceration by inhibiting matrix metalloproteinase-3 via down-regulation of inflammatory signaling cascade.
    Life sciences, 2022, May-15, Volume: 297

    Topics: Animals; Down-Regulation; Indomethacin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matr

2022
Role of ADMA/DDAH-1 and iNOS/eNOS signaling in the gastroprotective effect of tadalafil against indomethacin-induced gastric injury.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 150

    Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Indomethacin; Nitric Ox

2022
AMPK/mTOR-driven autophagy & Nrf2/HO-1 cascade modulation by amentoflavone ameliorates indomethacin-induced gastric ulcer.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 151

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Biflavonoids; Gastric Mucosa; Indomethacin; Male;

2022
Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:10

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Apoptosis; Caspase 3; Cholinergic Agents; Glutathi

2022
The effects of dragon fruit (Hylocereus polyrhizus) extract on indomethacin-induced stomach ulcer in rats.
    Journal of food biochemistry, 2022, Volume: 46, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; bcl-2-Associated

2022
Role of LTB4 and nitric oxide in the gastroprotective effect of
    Natural product research, 2023, Volume: 37, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Gastric Mucosa; Indomethacin; Leukotriene B4; Nitric Oxide

2023
The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2022, Volume: 33, Issue:9

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; DNA Nucleotidylexotransferase; Ethanol; Gastric Mucosa; In

2022
Therapeutic Versus Preventative Use of
    Molecules (Basel, Switzerland), 2022, Aug-31, Volume: 27, Issue:17

    Topics: Animals; Cyclooxygenase 2; Cytokines; Ginkgo biloba; Indomethacin; Mice; Plant Extracts; Proliferati

2022
RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats.
    Genes, 2022, Sep-27, Volume: 13, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Cytokines; Indomethacin; Interleukin-6; M

2022
Cembranoids from the Red Sea soft coral Sarcophyton glaucum protect against indomethacin-induced gastric injury.
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:2

    Topics: Animals; Anthozoa; Antioxidants; Diterpenes; Indian Ocean; Indomethacin; Rats; Stomach Ulcer; Transf

2023
Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration.
    The Journal of pharmacy and pharmacology, 2023, Mar-12, Volume: 75, Issue:3

    Topics: Animals; bcl-2-Associated X Protein; Caco-2 Cells; Chlorogenic Acid; Dinoprostone; Humans; Indometha

2023
Effect of phylloquinone on indomethacin-induced gastric ulceration in rats: Role of SIRT-1.
    Clinical and experimental pharmacology & physiology, 2023, Volume: 50, Issue:5

    Topics: Animals; Indomethacin; Rats; Stomach Ulcer; Tumor Necrosis Factor-alpha; Ulcer; Vitamin K 1

2023
Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 160

    Topics: Animals; Cyclooxygenase 2; Cytokines; Famotidine; Gastric Mucosa; Gastritis; HSP70 Heat-Shock Protei

2023
Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves.
    Journal of ethnopharmacology, 2023, Jun-12, Volume: 309

    Topics: Adenosine Triphosphate; Animals; Anti-Ulcer Agents; Apigenin; Bignoniaceae; Ethanol; Gastritis; Indo

2023
Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats.
    Inflammopharmacology, 2023, Volume: 31, Issue:3

    Topics: Animals; Carbon Monoxide; Cyclooxygenase 2; Gastric Mucosa; Indomethacin; NF-E2-Related Factor 2; Ra

2023
The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats.
    Nutrients, 2023, Mar-30, Volume: 15, Issue:7

    Topics: Animals; Cyclooxygenase 2; Cytokines; Gastric Mucosa; Indomethacin; Juglans; Oligopeptides; Rats; St

2023
Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis.
    Chinese journal of integrative medicine, 2023, Volume: 29, Issue:9

    Topics: Aesculus; Animals; Antioxidants; Glutathione; Indomethacin; Phytochemicals; Plant Extracts; Prostagl

2023
Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats.
    Journal of ethnopharmacology, 2023, Oct-05, Volume: 314

    Topics: Animals; Gastrointestinal Microbiome; Indomethacin; Medicine, Mongolian Traditional; Metabolomics; R

2023
Effect of felodipine on indomethacin-induced gastric ulcers in rats.
    Experimental animals, 2023, Nov-09, Volume: 72, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Famotidine; Felodipine; Indomethacin

2023
Gastro-protective effect of l-arginine against nitric oxide deficiency-related mucosal injury induced by indomethacin: Does age matter?
    Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:11

    Topics: Animals; Arginine; Dinoprostone; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ra

2023
Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt B

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cytokines; Ethanol; Indomethacin; Mice; Models, Theoretica

2024
Protective effect of Lizhong Pill on nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rats: Possible involvement of TNF and IL-17 signaling pathways.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt B

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Gastric Mucosa; Indomethacin; Interleuk

2024
Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT
    Digestive diseases and sciences, 2023, Volume: 68, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Apomorphine; Atropine; Bile Reflux; C

2023
Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 2

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Cytokines; Gastric Mucosa; Indom

2024
Flavonoid-Rich
    International journal of molecular sciences, 2023, Oct-23, Volume: 24, Issue:20

    Topics: Animals; Antioxidants; Flavonoids; Fruit; Glutathione; Indomethacin; Inflammation; NF-E2-Related Fac

2023
Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach.
    BMC complementary and alternative medicine, 2019, Aug-07, Volume: 19, Issue:1

    Topics: Achillea; Animals; Anti-Ulcer Agents; Humans; Indomethacin; Male; Metabolomics; Plant Extracts; Prot

2019
Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs.
    Science translational medicine, 2019, 10-30, Volume: 11, Issue:516

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cell Transdifferentiation; Cul

2019
Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids.
    Bioorganic chemistry, 2020, Volume: 94

    Topics: Administration, Oral; Aminosalicylic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachid

2020
Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms.
    Journal of pediatric gastroenterology and nutrition, 2019, Volume: 69, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Dipeptides; Gastric Mucosa; Humans;

2019
Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice.
    Nutrients, 2019, Dec-14, Volume: 11, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enteral Nutrition; Food, Formulated; Gastric Mucos

2019
Total triterpenes from the fruits of Chaenomeles speciosa (Sweet) Nakai protects against indomethacin-induced gastric mucosal injury: involvement of TFF1-mediated EGF/EGFR and apoptotic pathways.
    The Journal of pharmacy and pharmacology, 2020, Volume: 72, Issue:3

    Topics: Animals; Apoptosis; Caspase 3; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Epiderma

2020
Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Feb-15, Volume: 143

    Topics: Animals; Anti-Ulcer Agents; Centella; Drug Delivery Systems; Drug Liberation; Gastric Mucosa; Indome

2020
Total triterpenoids from the fruits of Chaenomeles speciosa exerted gastroprotective activities on indomethacin-induced gastric damage via modulating microRNA-423-5p-mediated TFF/NAG-1 and apoptotic pathways.
    Food & function, 2020, Jan-29, Volume: 11, Issue:1

    Topics: Animals; Apoptosis; Fruit; Growth Differentiation Factor 15; Humans; Indomethacin; Male; MicroRNAs;

2020
Evaluating the mucoprotective effect of polydeoxyribonucleotide against indomethacin-induced gastropathy via the MAPK/NF-κB signaling pathway in rats.
    European journal of pharmacology, 2020, May-05, Volume: 874

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Indomethacin; Male; Mitogen-Activa

2020
Agomelatine prevents indomethacin-induced gastric ulcer in rats.
    Pharmacological reports : PR, 2020, Volume: 72, Issue:4

    Topics: Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relat

2020
Effects of stress preconditioning on vulnerability of gastric and small intestinal mucosa to ulcerogenic action of indomethacin in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2019, Volume: 70, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Corticosterone; Gastric Mucosa; Indomethacin; Inte

2019
The prospective curative role of lipoxin A
    IUBMB life, 2020, Volume: 72, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Lipoxins;

2020
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.
    European journal of pharmacology, 2020, Jun-05, Volume: 876

    Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dual Oxidases; Duloxetine Hydrochloride; Gas

2020
Proton Pump Inhibitors Prevent Gastric Antral Ulcers Induced by NSAIDs via Activation of Capsaicin-Sensitive Afferent Nerves in Mice.
    Digestive diseases and sciences, 2020, Volume: 65, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Disease Models, Animal; Gastric Emptyin

2020
Synthesis of novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives as cyclooxygenase-2 inhibitors.
    Drug development research, 2020, Volume: 81, Issue:5

    Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Female;

2020
Anti-inflammatory, antioxidant, and gaso-protective mechanism of 3α-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage.
    Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Dinoprostone; Disease Models, An

2020
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats.
    BMC research notes, 2020, Apr-23, Volume: 13, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artesunate; Drug Therapy, Combination; Gastric Muco

2020
Pumpkin Oil-Based Nanostructured Lipid Carrier System for Antiulcer Effect in NSAID-Induced Gastric Ulcer Model in Rats.
    International journal of nanomedicine, 2020, Volume: 15

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cucurbita; Disease Models, Animal; Drug Carriers;

2020
Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway.
    Journal of ethnopharmacology, 2020, Sep-15, Volume: 259

    Topics: Animals; Anti-Ulcer Agents; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Gastric Mucosa

2020
LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats.
    Inflammopharmacology, 2020, Volume: 28, Issue:4

    Topics: Amides; Animals; Famotidine; Gene Expression; Indomethacin; Male; Nitric Oxide Synthase Type III; Ph

2020
Optimized Ellagic Acid-Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats.
    Biomolecules, 2020, 07-06, Volume: 10, Issue:7

    Topics: Animals; Disease Models, Animal; Ellagic Acid; Indomethacin; Male; Oxidative Stress; Particle Size;

2020
Cytoprotective and antisecretory properties of methanolic extract of
    Journal of complementary & integrative medicine, 2020, Jul-24, Volume: 18, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Caesalpinia; Cryoprotective Agents; Disease Models, Animal; Ethanol; Gas

2020
Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model.
    Current pharmaceutical design, 2022, Volume: 28, Issue:8

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Humans; Indomethacin; L

2022
Involvement of nitric oxide pathway in the anti-inflammatory effect of modafinil on indomethacin-, stress-, and ethanol -induced gastric mucosal injury in rat.
    European journal of pharmacology, 2020, Nov-15, Volume: 887

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Stimulants; Cytokines; Etha

2020
Gastroprotective and cicatrizing activity of the Ziziphus joazeiro Mart. leaf hydroalcoholic extract.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2020, Volume: 71, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Female; Gastric Mucosa; Indomethacin; M

2020
Nerolidol-beta-cyclodextrin inclusion complex enhances anti-inflammatory activity in arthritis model and improves gastric protection.
    Life sciences, 2021, Jan-15, Volume: 265

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arthritis; Arthritis, Experimental; beta-Cyclo

2021
New indomethacin analogs as selective COX-2 inhibitors: Synthesis, COX-1/2 inhibitory activity, anti-inflammatory, ulcerogenicity, histopathological, and docking studies.
    Archiv der Pharmazie, 2021, Volume: 354, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Cyclooxygenase 1;

2021
The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway.
    European journal of pharmacology, 2021, Feb-05, Volume: 892

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Metformin; N

2021
Possible protective effect of TNF-α inhibition and triad NO/cGMP/VEGF activation on gastric ulcer in rats.
    Canadian journal of physiology and pharmacology, 2021, Volume: 99, Issue:9

    Topics: Animals; Cyclic GMP; Dinoprostone; Indomethacin; Male; Malondialdehyde; Nitric Oxide; Pentoxifylline

2021
Efficacy of a Chitosan-curcumin Mixture in Treating Indomethacininduced Acute Gastric Ulcer in Rats.
    Current pharmaceutical biotechnology, 2021, Oct-06, Volume: 22, Issue:14

    Topics: Animals; Anti-Ulcer Agents; Chitosan; Curcumin; Gastric Mucosa; Indomethacin; Rats; Stomach Ulcer

2021
Obesity-associated up-regulation of lipocalin 2 protects gastric mucosa cells from apoptotic cell death by reducing endoplasmic reticulum stress.
    Cell death & disease, 2021, 02-26, Volume: 12, Issue:2

    Topics: Animals; Apoptosis; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Endoplasmic Retic

2021
Protective and therapeutic effects of the flavonoid "pinocembrin" in indomethacin-induced acute gastric ulcer in rats: impact of anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Apoptosis; Flavanones; Flavonoid

2021
Influence of forced treadmill and voluntary wheel running on the sensitivity of gastric mucosa to ulcerogenic stimuli in male rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2020, Volume: 71, Issue:6

    Topics: Animals; Cold Temperature; Corticosterone; Gastric Mucosa; Indomethacin; Male; Physical Conditioning

2020
Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling.
    Life sciences, 2021, Jun-15, Volume: 275

    Topics: Animals; Apoptosis; Autophagy; Chlorogenic Acid; Gastric Mucosa; Indomethacin; Male; Proto-Oncogene

2021
Anti-ulcerogenic effect of methanolic extract of Elaeagnus conferta Roxb. seeds in Wistar rats.
    Journal of ethnopharmacology, 2021, Jul-15, Volume: 275

    Topics: Animals; Anti-Ulcer Agents; Body Weight; Catalase; Elaeagnaceae; Gastric Mucosa; Glutathione; Hydrog

2021
Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Biomarkers; Goblet Cells;

2021
Attenuating Effect of Telfairia occidentalis on Oxidative Stress in Indomethacin-induced Gastric Ulcer in Male Rats.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2020, Dec-31, Volume: 35, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Gastric Mucosa; Indomethacin; Male; Oxidative Stress; Plant Extracts; Ra

2020
Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats.
    Food & function, 2021, Jul-07, Volume: 12, Issue:13

    Topics: Animals; Anti-Ulcer Agents; Apoptosis; Caspase 3; Esomeprazole; Female; Heme Oxygenase-1; Humans; In

2021
Evaluation of the Gastroprotective Effect of the Flavonoid Complex from Lychnis chalcedonica L. on the Models of Experimental Ulcerogenesis.
    Bulletin of experimental biology and medicine, 2021, Volume: 171, Issue:2

    Topics: Animals; Animals, Outbred Strains; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Ethano

2021
Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing.
    Journal of ethnopharmacology, 2021, Oct-28, Volume: 279

    Topics: Acanthaceae; Acetic Acid; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Res

2021
Gastroprotective Activities of Ethanol Extract of Black Rice Bran (
    Molecules (Basel, Switzerland), 2021, Jun-22, Volume: 26, Issue:13

    Topics: Animals; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Indomethacin; Male; Oryza; Phytotherapy; Plant

2021
A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway.
    Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase 2; Dinoprostone;

2021
Combined Effects of Medicinal Plants on Induced Upper Gastrointestinal Tract Injury in Wistar Rats.
    Ethiopian journal of health sciences, 2016, Volume: 26, Issue:6

    Topics: Aloe; Animals; Brassica; Dose-Response Relationship, Drug; Duodenal Ulcer; Female; Garlic; Indometha

2016
Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer.
    Chemico-biological interactions, 2017, Aug-01, Volume: 273

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Indomethacin; Inflammation; NF-E2-Relat

2017
Gastroprotective and Antiulcer Effects of Celastrus paniculatus Seed Oil Against Several Gastric Ulcer Models in Rats.
    Journal of dietary supplements, 2018, Jul-04, Volume: 15, Issue:4

    Topics: Animals; Celastrus; Disease Models, Animal; Ethanol; Female; Gastric Acidity Determination; Gastric

2018
Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome.
    Marine drugs, 2017, Nov-01, Volume: 15, Issue:11

    Topics: Animals; Carrageenan; Cytoprotection; Female; Indomethacin; Naphthoquinones; Polysaccharides; Rats,

2017
Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Disease Models, A

2018
Silver oxide nanoparticles alleviate indomethacin-induced gastric injury: a novel antiulcer agent.
    Inflammopharmacology, 2018, Volume: 26, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antio

2018
Chrysophyllum cainito (apple-star): a fruit with gastroprotective activity in experimental ulcer models.
    Inflammopharmacology, 2019, Volume: 27, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Female; Fruit; Gastric Mucosa; Indometh

2019
Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms.
    Life sciences, 2018, Jan-15, Volume: 193

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Cyclooxygenase 1; Cyclooxygenase 2; Dise

2018
Healing and Antisecretory Effects of Aqueous Extract of
    BioMed research international, 2017, Volume: 2017

    Topics: Acanthaceae; Acetic Acid; Animals; Antioxidants; Disease Models, Animal; Gastric Mucosa; Humans; Ind

2017
Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury.
    Acta pharmaceutica (Zagreb, Croatia), 2017, Dec-20, Volume: 67, Issue:4

    Topics: 2-Propanol; Animals; Anti-Ulcer Agents; Artemisia; Dogs; Ethanol; Flavonoids; Gastric Mucosa; Indome

2017
Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Jan-15, Volume: 39

    Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; D

2018
Zinc salt enhances gastroprotective activity of risperidone in indomethacin-induced gastric ulcer.
    African journal of medicine and medical sciences, 2016, Volume: 45, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chlorides; Dopamine Antagonists; Drug Synergism; I

2016
Lysophosphatidic acid in medicinal herbs enhances prostaglandin E
    Prostaglandins & other lipid mediators, 2018, Volume: 135

    Topics: Animals; Cell Death; Cell Proliferation; Dinoprostone; Indomethacin; Lysophospholipids; Mice; Plants

2018
Antioxidant and anti-inflammatory activities of alpha lipoic acid protect against indomethacin-induced gastric ulcer in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 101

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Indomethacin; Male; Nitric Oxide Synthase Type II;

2018
In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging.
    Antioxidants & redox signaling, 2019, 03-20, Volume: 30, Issue:9

    Topics: Animals; Cyclic N-Oxides; Indomethacin; Magnetic Resonance Spectroscopy; Male; Molecular Imaging; Ni

2019
Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cordia; Indomethacin; Inflammation Medi

2018
Combination therapy with polydeoxyribonucleotide and proton pump inhibitor enhances therapeutic effectiveness for gastric ulcer in rats.
    Life sciences, 2018, Jun-15, Volume: 203

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Indomethacin; Male; Pol

2018
Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats.
    Biomedical journal, 2018, Volume: 41, Issue:1

    Topics: Animals; Gastric Mucosa; Indomethacin; Liver; Male; Plant Extracts; Plantago; Protective Agents; Rat

2018
Oil from the fruits of Pterodon emarginatus Vog.: A traditional anti-inflammatory. Study combining in vivo and in silico.
    Journal of ethnopharmacology, 2018, Aug-10, Volume: 222

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Croton Oil; Cyclooxygenase

2018
Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats.
    Pharmaceutical biology, 2018, Volume: 56, Issue:1

    Topics: Alpinia; Animals; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Female; Gastric Mucosa; Indomethacin

2018
The gastroprotective effect of N-acetylcysteine and genistein in indomethacin-induced gastric injury in rats.
    Canadian journal of physiology and pharmacology, 2018, Volume: 96, Issue:11

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models,

2018
Gastroprotective and anti-ulcer effects of oxymatrine against several gastric ulcer models in rats: Possible roles of antioxidant, antiinflammatory, and prosurvival mechanisms.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:10

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Apoptosis; Catalase;

2018
Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 107

    Topics: Animals; Antioxidants; Gastric Juice; Gastric Mucosa; Indomethacin; Lipid Peroxidation; Male; Naphth

2018
Artepillin C, drupanin, aromadendrin-4'-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action.
    Journal of ethnopharmacology, 2018, Nov-15, Volume: 226

    Topics: Animals; Anti-Ulcer Agents; Cinnamates; Ethanol; Flavonoids; Hydrochloric Acid; Indomethacin; Kaempf

2018
Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats1.
    Acta cirurgica brasileira, 2018, Volume: 33, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Asphodelaceae; Dose-Response Relationship, Drug; Glutathio

2018
Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress.
    Life sciences, 2018, Sep-15, Volume: 209

    Topics: Acute Disease; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Ag

2018
[MECHANISMS OF PROULCEROGENIC EFFECT OF CORTISOL AT PHARMACOLOGICAL DOSE ON THE GASTRIC MUCOSA].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2016, Volume: 102, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Body Weight; Gastric Mucosa; Hydrocortisone; Indom

2016
[TRANSFORMATION OF GASTROPRO- TECTIVE EFFECT OF STRESS IN PROULCEROGENIC CONSEGUENCE: DEVELOPMENT OF EXPERIMENTAL MODELS].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2017, Volume: 103, Issue:2

    Topics: Adaptation, Physiological; Animals; Cold Temperature; Darkness; Immobilization; Indomethacin; Male;

2017
Chemical composition, antioxidant and gastrointestinal properties of Sedum dendroideum Moc & Sessé ex DC leaves tea infusion.
    Journal of ethnopharmacology, 2019, Mar-01, Volume: 231

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Caco-2 Cells; Ethanol; Female; Humans; Indomethacin; Mice;

2019
Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats.
    Human & experimental toxicology, 2019, Volume: 38, Issue:5

    Topics: Acetophenones; Animals; Anti-Ulcer Agents; Caspase 3; Gastric Mucosa; Gene Expression Regulation; Gl

2019
Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model.
    Annals of hepatology, 2018, Oct-16, Volume: 17, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liv

2018
Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70.
    Journal of basic and clinical physiology and pharmacology, 2019, Feb-07, Volume: 30, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Fluvoxa

2019
Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.
    BMC complementary and alternative medicine, 2019, Feb-20, Volume: 19, Issue:1

    Topics: Animals; Antioxidants; Fermentation; Gastric Mucosa; Hordeum; Indomethacin; Lipid Peroxidation; Male

2019
Vulnerability of gastric and small intestinal mucosa to ulcerogenic action of indomethacin in C57/BL6/J mice and transient receptor potential channel vanilloid type 1 knockout mice.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2018, Volume: 69, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Gastric Mucosa; Indomethacin; Intestina

2018
Anti-oxidant and anti-inflamatuar effectiveness of caftaric acid on gastric ulcer induced by indomethacin in rats.
    General physiology and biophysics, 2019, Volume: 38, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Female; Indomethacin; Oxidants; Phenols; Rats; Rats, Sprag

2019
Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice.
    Food research international (Ottawa, Ont.), 2019, Volume: 119

    Topics: Animals; Antioxidants; Brazil; Catechin; Chromatography, High Pressure Liquid; Disease Models, Anima

2019
Gastroprotective Effects of Plants Extracts on Gastric Mucosal Injury in Experimental Sprague-Dawley Rats.
    BioMed research international, 2019, Volume: 2019

    Topics: Animals; Gastric Mucosa; Gastritis; Indomethacin; Male; Phytotherapy; Plant Extracts; Plant Leaves;

2019
Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer.
    Life sciences, 2019, May-01, Volume: 224

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Crocus; Cyclohexenes; Indometha

2019
Evaluation of the antiulcer activity of the aqueous stem bark extract of Balanites aegyptiaca L Delile in Wistar rats.
    Journal of ethnopharmacology, 2019, Jul-15, Volume: 239

    Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Balanites; Ethanol; Indomethacin; Ligation; Male; Phytother

2019
Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats.
    BioMed research international, 2019, Volume: 2019

    Topics: Aluminum Hydroxide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygena

2019
Antiulcer activity of Cyperus alternifolius in relation to its UPLC-MS metabolite fingerprint: A mechanistic study.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 62

    Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Chromatography, Liquid;

2019
A bis-resorcinol resveratrol congener prevents indomethacin-induced gastric ulceration by inhibiting TNF-α as well as NF-κB and JNK pathways.
    Free radical research, 2019, Volume: 53, Issue:6

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Indomethacin; JNK Mitogen-Activated Protein Kinase

2019
Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats.
    Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:7

    Topics: Animals; Aspirin; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Gastric

2019
A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats.
    Molecular biology reports, 2019, Volume: 46, Issue:5

    Topics: Animals; Antioxidants; Biomarkers; Biopsy; Cytokines; Disease Models, Animal; Esomeprazole; Immunohi

2019
[Therapeutic effect of total triterpenoids of Chaenomeles speciosa combined with omeprazole on gastric ulcer induced by indomethacin in rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019, Volume: 44, Issue:11

    Topics: Animals; Cytokines; Gastric Mucosa; Indomethacin; Omeprazole; Phytochemicals; Random Allocation; Rat

2019
Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 132

    Topics: Alchemilla; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Disease Models, Animal;

2019
Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats.
    Journal of physiology and biochemistry, 2013, Volume: 69, Issue:3

    Topics: Administration, Oral; Animals; Catalase; Dinoprostone; Drug Synergism; Gastric Mucosa; Glutathione;

2013
Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy.
    Biochimica et biophysica acta, 2013, Volume: 1830, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catechols; Disease Models, Anim

2013
Extraction optimization of carbohydrate compound from Huangqi using orthogonal design.
    International journal of biological macromolecules, 2013, Volume: 58

    Topics: Animals; Astragalus Plant; Astragalus propinquus; Catalase; Drugs, Chinese Herbal; Glutathione; Glut

2013
Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats.
    Pharmacology, 2013, Volume: 91, Issue:5-6

    Topics: Animals; Catalase; Curcumin; Gastric Mucosa; Indomethacin; Male; Malondialdehyde; Nitric Oxide; Prot

2013
Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice.
    Glycoconjugate journal, 2013, Volume: 30, Issue:8

    Topics: Animals; Cell Extracts; Cytokines; Dinoprostone; Fungal Polysaccharides; Indomethacin; Mice; Mucins;

2013
Gastric antisecretory and antiulcer activity of bovine hemoglobin.
    World journal of gastroenterology, 2013, Jun-07, Volume: 19, Issue:21

    Topics: Animals; Anti-Ulcer Agents; Cattle; Cytoprotection; Disease Models, Animal; Dose-Response Relationsh

2013
Nonsteroidal anti-inflammatory drugs (NSAID) sparing effects of glucosamine hydrochloride through N-glycosylation inhibition; strategy to rescue stomach from NSAID damage.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2013, Volume: 64, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Glucosamine; Glycosyl

2013
The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2012, Volume: 23, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Drug Interactions; Folic Acid; Gastric M

2012
Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2013, Volume: 24, Issue:2

    Topics: Acetates; Animals; Anti-Ulcer Agents; Cyclopropanes; Disease Models, Animal; Famotidine; Gastric Muc

2013
Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2012, Volume: 9, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Carbolines; Cimetidine; Dose-Response Relationship, Drug; Gastric Acid;

2012
Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2012, Volume: 9, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antipyretics; Carrageenan; Dinopro

2012
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Animals; Anti-Inflammatory Agents; Benzamides; Carrageenan; Dinoprostone; Disease Models, Animal; Ed

2013
Effect of menthol in experimentally induced ulcers: pathways of gastroprotection.
    Chemico-biological interactions, 2013, Nov-25, Volume: 206, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channels; Castor Oil; Cyclic GMP; Diarrhea

2013
Does chronic stress enhance the risk of diseases?
    Endocrine regulations, 2013, Volume: 47, Issue:4

    Topics: Adrenergic alpha-Antagonists; Angina Pectoris; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chr

2013
Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:4

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethanol; Indometha

2014
Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats.
    World journal of gastroenterology, 2014, Mar-14, Volume: 20, Issue:10

    Topics: Alginates; Anemia; Animals; Anti-Ulcer Agents; Atrophy; Bacterial Translocation; Biomarkers; Capilla

2014
The impact of dehydroepiandrosterone on indomethacin-induced gastric lesions in rats.
    Acta physiologica Hungarica, 2014, Volume: 101, Issue:1

    Topics: Animals; Antioxidants; Catalase; Cytoprotection; Dehydroepiandrosterone; Disease Models, Animal; Gas

2014
Cytoprotective and antioxidant effects of the methanol extract of Eremomastax speciosa in rats.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2014, Volume: 11, Issue:1

    Topics: Acanthaceae; Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Cold Temperature; Ethanol; Gastric

2014
Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Jun-15, Volume: 21, Issue:7

    Topics: Animals; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Diterpenes, Clerodane; Enzyme Inhibitor

2014
Intravenous ilaprazole is more potent than oral ilaprazole against gastric lesions in rats.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:10

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric A

2014
Gastric antiulcerogenic and hypokinetic activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae).
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Antioxidants; Combretaceae; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Mice; Nitr

2014
Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2013, Dec-20, Volume: 28, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Indomethacin; Ma

2013
L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin.
    Journal of natural medicines, 2014, Volume: 68, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Glutamates; Indomethacin; Lipid Pero

2014
The effect of induction of endogenous CO by heme-oxygenase inducer, hemin versus heme-oxygenase blocker, zinc mesoporphyrin on gastric secretion and ulceration under different conditions in adult male albino rats.
    Bratislavske lekarske listy, 2014, Volume: 115, Issue:6

    Topics: Animals; Carbon Monoxide; Cold-Shock Response; Cyclooxygenase Inhibitors; Gastric Juice; Gastric Muc

2014
Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms.
    The Journal of surgical research, 2015, Volume: 193, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Appetite Depressants; Calcium-Bindin

2015
Protective effects of escin against indomethacin-induced gastric ulcer in mice.
    Toxicology mechanisms and methods, 2014, Volume: 24, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Dose-Response Rel

2014
Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice.
    Journal of ethnopharmacology, 2014, Sep-29, Volume: 155, Issue:3

    Topics: Acetic Acid; Adrenergic alpha-2 Receptor Antagonists; Animals; Anti-Ulcer Agents; Cyclooxygenase Inh

2014
Gastroprotective activity of violacein isolated from Chromobacterium violaceum on indomethacin-induced gastric lesions in rats: investigation of potential mechanisms of action.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: Animals; Apoptosis; Chromobacterium; Female; Indoles; Indomethacin; Male; Prostaglandins; Protective

2014
Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats.
    Chemico-biological interactions, 2014, Oct-05, Volume: 222

    Topics: Animals; Anti-Ulcer Agents; Catalase; Cytokines; Dinoprostone; Drugs, Chinese Herbal; Ethanol; Gastr

2014
Antiulcer activity of the ethanolic extract and ethyl acetate fraction of the leaves of Markhamia tomentosa in rats.
    Journal of ethnopharmacology, 2014, Nov-18, Volume: 157

    Topics: Acetates; Animals; Anti-Ulcer Agents; Bignoniaceae; Chromatography, Liquid; Disease Models, Animal;

2014
Rational Design and Synthesis of Benzamides as Non-ulcerogenic Anti-inflammatory Agents.
    Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2015, Volume: 13, Issue:3

    Topics: Animals; Benzamides; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Carrageenan; Cyclooxy

2015
Antiulcerogenic activity of Carica papaya seed in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2015, Volume: 388, Issue:3

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carica; Ethanol; F

2015
Gastroprotective effects of goniothalamin against ethanol and indomethacin-induced gastric lesions in rats: Role of prostaglandins, nitric oxide and sulfhydryl compounds.
    Chemico-biological interactions, 2014, Dec-05, Volume: 224

    Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; N

2014
[Somatic pain sensitivity under indometacin induced gastric and small intestinal injury in rats].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2014, Volume: 100, Issue:1

    Topics: Adrenal Glands; Animals; Body Weight; Corticosterone; Fasting; Gastric Mucosa; Indomethacin; Intesti

2014
Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats.
    Natural product research, 2015, Volume: 29, Issue:22

    Topics: Animals; Anti-Ulcer Agents; Catalase; Cucurbitaceae; Dinoprostone; Gastric Juice; Gastric Mucosa; In

2015
A wider view on gastric erosion: detailed evaluation of complex somatic and behavioral changes in rats treated with indomethacin at gastric ulcerogenic dose.
    Endocrine regulations, 2014, Volume: 48, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Body Temperature; Brain; Dose-Re

2014
S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibition.
    Journal of gastroenterology and hepatology, 2014, Volume: 29 Suppl 4

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cyclooxyge

2014
Primary characterization and evaluation of anti ulcerogenic activity of an aqueous extract from callus culture of Cereus peruvianus Mill. (Cactaceae).
    Current pharmaceutical biotechnology, 2015, Volume: 16, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Cactaceae; Carbohydrates; Ethanol; Indomethacin; Male; Plant Extracts; P

2015
Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.
    Nutrients, 2015, Mar-13, Volume: 7, Issue:3

    Topics: Alanine; Animals; Anti-Ulcer Agents; Artemisia; Coumarins; Ethanol; Hydrochloric Acid; Indomethacin;

2015
Helicteres sacarolha A. St.- Hil. et al.: gastroprotective and possible mechanism of actions in experimental animals.
    Journal of ethnopharmacology, 2015, May-26, Volume: 166

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Ethanol; Gastric Juice; Gastric Mucosa; Glyburid

2015
Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats.
    Journal of integrative medicine, 2015, Volume: 13, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Carica; Disease Models, Animal; Dose-Response Relationship, Drug; Duoden

2015
Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata.
    Pharmaceutical biology, 2016, Volume: 54, Issue:1

    Topics: Anacardiaceae; Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Dose-Response Rel

2016
The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats.
    Clinical nutrition (Edinburgh, Scotland), 2016, Volume: 35, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carotenoids; Catalase; Comet Assay;

2016
In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice.
    Planta medica, 2015, Volume: 81, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Biological Availability; Chalcones; Flavanones; Gastric Mucosa; Glycyrrh

2015
Boswellia carterii liquisolid systems with promoted anti-inflammatory activity.
    Current drug delivery, 2015, Volume: 12, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Cellulose; Chemistr

2015
Gastroprotective potential of Buddleja scordioides Kunth Scrophulariaceae infusions; effects into the modulation of antioxidant enzymes and inflammation markers in an in vivo model.
    Journal of ethnopharmacology, 2015, Jul-01, Volume: 169

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biomarkers; Buddleja; Down-Regulation; Gastric Mucosa; Ind

2015
Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats.
    International immunopharmacology, 2015, Volume: 26, Issue:2

    Topics: Animals; Antioxidants; Catalase; Dinoprostone; Diterpenes; Gastric Mucosa; Glutathione; HSP70 Heat-S

2015
[Metyrapone effect on gastroprotective action of corticotropin-releasing factor administered centrally against indomethacin-induced gastric injury].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2014, Volume: 100, Issue:12

    Topics: Animals; Corticosterone; Corticotropin-Releasing Hormone; Gastric Mucosa; Glucocorticoids; Indometha

2014
N-Acetyl Cysteine Has Both Gastro-Protective and Anti-Inflammatory Effects in Experimental Rat Models: Its Gastro-Protective Effect Is Related to Its In Vivo and In Vitro Antioxidant Properties.
    Journal of cellular biochemistry, 2016, Volume: 117, Issue:2

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Catalase; Drug Evaluat

2016
Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity.
    International journal of nanomedicine, 2015, Volume: 10

    Topics: Animals; Bignoniaceae; Cell Survival; Cells, Cultured; Chitosan; Disease Models, Animal; Drug Carrie

2015
Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits.
    AAPS PharmSciTech, 2016, Volume: 17, Issue:2

    Topics: Acrylic Resins; Animals; Anti-Ulcer Agents; Biological Availability; Boswellia; Carboxymethylcellulo

2016
Gastroprotective potential against indomethacin and safety assessment of the homology of medicine and food formula cuttlebone complex.
    Food & function, 2015, Volume: 6, Issue:8

    Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Gastric Mucosa; Humans; Indomethacin; Male; Mice; Mice,

2015
Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS.
    Prostaglandins & other lipid mediators, 2015, Volume: 121, Issue:Pt A

    Topics: Amidines; Animals; Atorvastatin; Benzylamines; Dinoprostone; Drug Synergism; Female; Indomethacin; M

2015
Gastroprotective bio-guiding study of fruits from Mimusops balata.
    Naunyn-Schmiedeberg's archives of pharmacology, 2015, Volume: 388, Issue:11

    Topics: Animals; Anti-Ulcer Agents; Ethanol; Female; Free Radical Scavengers; Fruit; Gastric Mucosa; Glutath

2015
The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats.
    Experimental biology and medicine (Maywood, N.J.), 2016, Volume: 241, Issue:2

    Topics: Administration, Oral; Animals; Disease Models, Animal; Gastric Mucosa; Gastrointestinal Agents; Hist

2016
Protective activity of crocin against indomethacin-induced gastric lesions in rats.
    Journal of natural medicines, 2016, Volume: 70, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotenoi

2016
New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies.
    Archiv der Pharmazie, 2015, Volume: 348, Issue:12

    Topics: Animals; Carrageenan; Coumarins; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Di

2015
Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats.
    Journal of medicinal food, 2016, Volume: 19, Issue:1

    Topics: Animals; Centella; Cyclooxygenase 2; Gastric Mucosa; Humans; Indomethacin; Male; Malondialdehyde; Pl

2016
Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms.
    Food & function, 2016, Volume: 7, Issue:1

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethylmaleimide; Glyb

2016
Gastroprotective and Antioxidant Effects of Lobaria pulmonaria and Its Metabolite Rhizonyl Alcohol on Indomethacin-Induced Gastric Ulcer.
    Chemistry & biodiversity, 2015, Volume: 12, Issue:11

    Topics: Alcohols; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationsh

2015
Synthesis, Structure Activity Relationship (SAR), and Biological Activities of Benzylideneacetophenones Derivatives.
    Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2015, Volume: 14, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Carrageenan; Chalcones; Edema; F

2015
Αlpha-2 Adrenergic and Opioids Receptors Participation in Mice Gastroprotection of Abelmoschus esculentus Lectin.
    Current pharmaceutical design, 2016, Volume: 22, Issue:30

    Topics: Abelmoschus; Animals; Ethanol; Indomethacin; Lectins; Male; Mice; Protective Agents; Receptors, Adre

2016
Antiulcer mechanisms of Vernonia condensata Baker: A medicinal plant used in the treatment of gastritis and gastric ulcer.
    Journal of ethnopharmacology, 2016, May-26, Volume: 184

    Topics: Animals; Anti-Ulcer Agents; Catalase; Ethanol; Female; Gastric Mucosa; Gastritis; Glutathione; H(+)-

2016
Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats.
    Journal of immunotoxicology, 2016, Volume: 13, Issue:5

    Topics: Alcohols; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Fluoxetine; Gastric Mucosa; Hist

2016
The renin-angiotensin system and its vasoactive metabolite angiotensin-(1-7) in the mechanism of the healing of preexisting gastric ulcers. The involvement of Mas receptors, nitric oxide, prostaglandins and proinflammatory cytokines.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2016, Volume: 67, Issue:1

    Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cytokines; Enzyme

2016
[Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:4

    Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal

2016
Nebivolol prevents indomethacin-induced gastric ulcer in rats.
    Journal of immunotoxicology, 2016, Volume: 13, Issue:4

    Topics: Adrenergic beta-1 Receptor Agonists; Animals; Dinoprostone; Glutathione; Humans; Indomethacin; Male;

2016
Anti-ulcer mechanisms of polyphenols extract of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae).
    Journal of ethnopharmacology, 2016, Sep-15, Volume: 191

    Topics: Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, Hig

2016
Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer.
    Journal of agricultural and food chemistry, 2016, Sep-21, Volume: 64, Issue:37

    Topics: Animals; Edible Grain; Fagopyrum; Gastric Mucosa; Glycine max; Humans; Indomethacin; Male; Mice; Mic

2016
Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers.
    Chemico-biological interactions, 2016, Oct-25, Volume: 258

    Topics: Amides; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Dinoprostone; Fumarates; Glutathione

2016
Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice.
    International journal of medical sciences, 2016, Volume: 13, Issue:9

    Topics: Alginates; Animals; Disease Models, Animal; Gastrointestinal Motility; Glucuronic Acid; Hexuronic Ac

2016
Complementarity of in vitro and in vivo models for the evaluation of gastro-protective effects of pharmacological substances.
    Fundamental & clinical pharmacology, 2017, Volume: 31, Issue:2

    Topics: Alanine; Animals; Anti-Ulcer Agents; Cimetidine; Dose-Response Relationship, Drug; Gastric Mucosa; I

2017
Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats.
    Folia morphologica, 2017, Volume: 76, Issue:2

    Topics: Acute Disease; Animals; Gastric Fundus; Gastric Mucosa; Glutathione; Hydrogen-Ion Concentration; Ind

2017
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
    Chemico-biological interactions, 2017, Jan-05, Volume: 261

    Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Mod

2017
Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages.
    Journal of molecular medicine (Berlin, Germany), 2017, Volume: 95, Issue:4

    Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Cell Line; Chloroquine; Endopl

2017
Isolation, characterization, and in silico, in vitro and in vivo antiulcer studies of isoimperatorin crystallized from Ostericum koreanum.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Apiaceae; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Cell

2017
Gastroprotective activity of the resin from Virola oleifera.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, Thin Layer; Disease Models

2017
N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; A

2017
Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats.
    Bratislavske lekarske listy, 2016, Volume: 117, Issue:12

    Topics: Angiotensin I; Animals; Anti-Ulcer Agents; Dinoprostone; Gastric Juice; Gastric Mucosa; Indomethacin

2016
Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Aluminum Hydroxide; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Dose-

2017
Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol.
    Inflammopharmacology, 2018, Volume: 26, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Bauhinia; Flavonoids; Gastric Mucosa; Indomethacin; Kaempferols; Male; M

2018
Gastroprotective and anti-secretory mechanisms of 2-phenylquinoline, an alkaloid isolated from Galipea longiflora.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Feb-15, Volume: 25

    Topics: Alkaloids; Animals; Anti-Ulcer Agents; Antioxidants; Ethanol; Gastric Acid; Gastric Juice; Gastric M

2017
Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Croton; Croton Oil; Ethanol; Fe

2017
Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:10

    Topics: Animals; Eugenol; Gastric Mucosa; Glyburide; Indomethacin; Male; Malondialdehyde; Nitrites; Rats; Ra

2008
Gastroprotective mechanisms of centipedic acid, a natural diterpene from Egletes viscosa LESS.
    Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:7

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Asteraceae; Cap

2008
Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models.
    Journal of ethnopharmacology, 2008, Aug-13, Volume: 118, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Ethanol; Female; Gastric Mucosa; Glutathione; India; Indomethacin; Male;

2008
Beneficial effects of vegetable oils (corn, olive and sunflower oils) and alpha-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats.
    European journal of pharmacology, 2008, Sep-04, Volume: 591, Issue:1-3

    Topics: alpha-Tocopherol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Corn Oil; Indometh

2008
Antiulcer activity of water extract of Scoparia dulcis.
    Fitoterapia, 2008, Volume: 79, Issue:7-8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Indomethacin; Ph

2008
Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats.
    World journal of gastroenterology, 2008, Aug-14, Volume: 14, Issue:30

    Topics: Animals; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models,

2008
Gastroprotective and anti-oxidative properties of ascorbic acid on indomethacin-induced gastric injuries in rats.
    Biological trace element research, 2008,Winter, Volume: 126, Issue:1-3

    Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Gastric Mucosa; Glutathione Peroxidase; Glutathione

2008
The antiinflammatory, gastroprotective and antioxidant activities of Hieracium gymnocephalum extract.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Asteraceae; Dose-Response Relati

2008
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
    Life sciences, 2008, Nov-21, Volume: 83, Issue:21-22

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Fre

2008
Gastroprotective effect of nicorandil in indomethacin and alcohol-induced acute ulcers.
    Applied biochemistry and biotechnology, 2009, Volume: 152, Issue:3

    Topics: Acute Disease; Animals; Ethanol; Gastric Mucosa; Indomethacin; Male; Nicorandil; Nitric Oxide; Prote

2009
Gastric anti-ulcer activity of leaf fractions obtained of polar extract from Wilbrandia ebracteata in mice.
    Natural product research, 2009, Volume: 23, Issue:1

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Biphenyl Compounds; Brazil; Cucurbitaceae; Flavono

2009
Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil.
    Fitoterapia, 2009, Volume: 80, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Anti-Ulcer Agents; Asteraceae; Enzyme Inhibitors; Ethanol; Ga

2009
Myristica malabarica heals stomach ulceration by increasing prostaglandin synthesis and angiogenesis.
    Planta medica, 2008, Volume: 74, Issue:15

    Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; D

2008
Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters.
    Digestive diseases and sciences, 2009, Volume: 54, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antidepressive Agents, Tricycli

2009
Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Antineoplastic Agents; Cyclooxygenase 1; Cyclooxygenase 2; Indomethacin;

2009
The effects of methanol extract of Lobaria pulmonaria, a lichen species, on indometacin-induced gastric mucosal damage, oxidative stress and neutrophil infiltration.
    Phytotherapy research : PTR, 2009, Volume: 23, Issue:5

    Topics: Animals; Catalase; Dose-Response Relationship, Drug; Gastric Mucosa; Glutathione; Glutathione Peroxi

2009
[Suppression of hypotalamic-pituitary-adrenocortical system as a reason of aggravation of indomethacin-induced gastric ulcerogenic effect by cortisol treatment with pharmacological dose].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2008, Volume: 94, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Corticosterone; Hydrocortisone; Hypothalamo-Hypoph

2008
Antiulcerogenic action of ethanolic extract of the resin from Virola surinamensis Warb. (Myristicaceae).
    Journal of ethnopharmacology, 2009, Mar-18, Volume: 122, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catechin; Cimetidine; Cold Temp

2009
Antiulcerogenic activity of Combretum leprosum.
    Die Pharmazie, 2009, Volume: 64, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Combretum; Ethanol; Gastric Aci

2009
Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins.
    European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arginine; Dinoprostone; Drug In

2009
Anti-ulcer activity of IAC, a novel free-radical scavenger, in rats.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxida

2009
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2009, Volume: 41, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Caspase 3; Dinopr

2009
Effects of amodiaquine hydrochloride and artemisinin on indomethacin-induced lipid peroxidation in rats.
    Pakistan journal of biological sciences : PJBS, 2008, Sep-01, Volume: 11, Issue:17

    Topics: Amodiaquine; Animals; Artemisinins; Gastric Juice; Indomethacin; Lipid Peroxidation; Rats; Rats, Wis

2008
Regulation of arginase/nitric oxide synthesis axis via cytokine balance contributes to the healing action of malabaricone B against indomethacin-induced gastric ulceration in mice.
    International immunopharmacology, 2009, Volume: 9, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arginase; Cytokines; Indomethac

2009
Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats.
    Journal of gastroenterology, 2009, Volume: 44, Issue:5

    Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents

2009
[Ulcer genesis and endogenous intoxication].
    Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2008, Issue:6

    Topics: Animals; Disease Models, Animal; Endotoxemia; Gastric Mucosa; Indomethacin; Lipid Metabolism; Lipids

2008
Biphasic activity of resveratrol on indomethacin-induced gastric ulcers.
    Biochemical and biophysical research communications, 2009, Mar-27, Volume: 381, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cyclooxygenase 1; Indomethacin;

2009
Gastrointestinal safety and therapeutic efficacy of parenterally administered phosphatidylcholine-associated indomethacin in rodent model systems.
    British journal of pharmacology, 2009, Volume: 157, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dinoprostone

2009
The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats.
    Saudi medical journal, 2009, Volume: 30, Issue:4

    Topics: Animals; Indomethacin; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Stomach Ulcer

2009
Chemical characterization of the lipophilic fraction of Livistona decipiens and Livistona chinensis fruit pulps (Palmae) and assessment of their anti-hyperlipidemic and anti-ulcer activities.
    Natural product communications, 2009, Volume: 4, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Arecaceae; Dietary Fats; Fruit; Hyperlipidemias; Hypolipidemic Agents; I

2009
Rocket "Eruca sativa": a salad herb with potential gastric anti-ulcer activity.
    World journal of gastroenterology, 2009, Apr-28, Volume: 15, Issue:16

    Topics: Animals; Anti-Ulcer Agents; Brassicaceae; Ethanol; Gastric Mucosa; Humans; Indomethacin; Mucus; Plan

2009
A role for HSP70 in protecting against indomethacin-induced gastric lesions.
    The Journal of biological chemistry, 2009, Jul-17, Volume: 284, Issue:29

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Cell Line,

2009
Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue.
    BMC gastroenterology, 2009, May-20, Volume: 9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Dose-Re

2009
Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:3

    Topics: Animals; Antioxidants; Cyclohexane Monoterpenes; Disease Models, Animal; Dose-Response Relationship,

2009
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).
    Chemico-biological interactions, 2009, Jul-15, Volume: 180, Issue:2

    Topics: Alkaloids; Animals; Anti-Ulcer Agents; Bethanechol; Dose-Response Relationship, Drug; Ethanol; Hydro

2009
Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats.
    Chemico-biological interactions, 2009, Jul-15, Volume: 180, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Antidepressive Agents; Cyclohexanols; Famotidine; Indomethacin; Male; Ra

2009
Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin.
    Journal of pineal research, 2009, Volume: 47, Issue:1

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Enzyme Induction; Gastri

2009
Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:2

    Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dinoprostone; Gastric

2010
Gastroprotective and antioxidant effects of opipramol on indomethacin-induced ulcers in rats.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2009, Volume: 129, Issue:7

    Topics: Animals; Antidepressive Agents, Tricyclic; Antioxidants; Catalase; Gastric Mucosa; Glutathione; Indo

2009
Protective Effect of Origanum majorana L. 'Marjoram' on various models of gastric mucosal injury in rats.
    The American journal of Chinese medicine, 2009, Volume: 37, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Drugs, Chine

2009
Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: role of nitric oxide, prostaglandins and sulfydryls.
    Fitoterapia, 2010, Volume: 81, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Benzopyrans; Carbenoxolone; Drug Evaluation, Preclinical; Ethanol; Ethyl

2010
Evaluation of gastric toxicity of indomethacin acid, salt form and complexed forms with hydroxypropyl-beta-cyclodextrin on Wistar rats: histopathologic analysis.
    Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:6

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyc

2009
Gastroprotective effect of dalargin in gastropathy due to treatment with nonsteroid antiinflammatory drugs.
    Bulletin of experimental biology and medicine, 2009, Volume: 147, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; DNA; Drug Interactions; Enkeph

2009
Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives.
    Arzneimittel-Forschung, 2009, Volume: 59, Issue:7

    Topics: Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoqu

2009
Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers.
    Natural product communications, 2009, Volume: 4, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Central Nervous System Depressa

2009
Antiulcer and anticonvulsant activity of Croton zambesicus.
    Pakistan journal of pharmaceutical sciences, 2009, Volume: 22, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticonvulsants; Antipsychotic

2009
[Effect of dexamethasone on indomethacin-induced gastric erosion formation upon duration of the hormonal action].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2009, Volume: 95, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Gastric Mucosa; Glucocorticoids; In

2009
Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats.
    Die Pharmazie, 2009, Volume: 64, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce

2009
Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent.
    European journal of pharmacology, 2010, Feb-10, Volume: 627, Issue:1-3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Capillary Permeability; Gastric Mucosa; Indomethacin; Male

2010
EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing.
    World journal of gastroenterology, 2009, Nov-07, Volume: 15, Issue:41

    Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose

2009
Synthesis and biological activities of new substituted thiazoline-quinoline derivatives.
    Acta pharmaceutica (Zagreb, Croatia), 2009, Volume: 59, Issue:4

    Topics: Acetophenones; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal A

2009
Gastroprotective activity of Trichosanthes cucumerina in rats.
    Journal of ethnopharmacology, 2010, Feb-17, Volume: 127, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Ethanol; Female; Gastric Juice; Gast

2010
The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage.
    Journal of gastroenterology, 2010, Volume: 45, Issue:2

    Topics: Acetylcholine; Administration, Oral; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflamma

2010
Suppression of hypothalamo-hypophyseal-adrenocortical system function as the cause of aggravation of the ulcerogenic action of indomethacin on the stomach after administration of pharmacological doses of hydrocortisone.
    Neuroscience and behavioral physiology, 2010, Volume: 40, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Corticoster

2010
Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.
    Journal of ethnopharmacology, 2010, Feb-17, Volume: 127, Issue:3

    Topics: Acetylcysteine; Animals; Anti-Ulcer Agents; Antioxidants; Capsaicin; Disease Models, Animal; Diterpe

2010
Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats.
    Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:4

    Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogens;

2010
Pathogenic importance of cysteinyl leukotrienes in development of gastric lesions induced by ischemia/reperfusion in mice.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Chromones; Gastric Ac

2010
Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine.
    British journal of pharmacology, 2010, Feb-01, Volume: 159, Issue:3

    Topics: Animals; Antineoplastic Agents; Arginine; Cyclooxygenase 1; Cyclooxygenase 2; Indomethacin; Male; Mi

2010
Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury.
    Regulatory peptides, 2010, Apr-09, Volume: 161, Issue:1-3

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Blood Glucose; Corticosterone; Female; Gastric Mucosa;

2010
Gastric acid is the key modulator in the pathogenesis of non-steroidal anti-inflammatory drug-induced ulceration in rats.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase

2010
Anti-ulcerogenic effect and HPLC analysis of the caffeoylquinic acid-rich extract from Ligularia stenocephala.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Asteraceae; Bethanechol; Chromatography, High Pressure Liquid; Ethanol;

2010
Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2009, Mar-07, Volume: 6, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Indomethacin; Magnoliopsida; Phytotherapy; Plant

2009
Probiotic bacteria Escherichia coli strain Nissle 1917 attenuates acute gastric lesions induced by stress.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2009, Volume: 60 Suppl 6

    Topics: Animals; Capsaicin; Cyclooxygenase 2; Disease Models, Animal; Escherichia coli; Gastric Mucosa; Ghre

2009
Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration.
    European journal of pharmacology, 2010, Jul-10, Volume: 637, Issue:1-3

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Benzoates; Blood Glu

2010
Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action.
    Inflammopharmacology, 2010, Volume: 18, Issue:3

    Topics: Acetylcholine; Animals; Aspirin; Atropine; Cholinergic Antagonists; Cimetidine; Ethanol; Flax; Gastr

2010
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
    Neuropharmacology, 2010, Volume: 59, Issue:3

    Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Rele

2010
Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2.
    Journal of pineal research, 2010, Volume: 49, Issue:2

    Topics: Analysis of Variance; Animals; Gastric Mucosa; Histocytochemistry; Indomethacin; Male; Matrix Metall

2010
Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury.
    The Journal of pharmacology and experimental therapeutics, 2010, Sep-01, Volume: 334, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antisense Elements (Genetics); Apoptosis; Caspase

2010
Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models.
    Journal of ethnopharmacology, 2010, Jul-20, Volume: 130, Issue:2

    Topics: Achyrocline; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Cytoprotection; Disease Models, Animal;

2010
Influence of cyclodextrin complexation with NSAIDs on NSAID/cold stress-induced gastric ulceration in rats.
    International journal of medical sciences, 2010, Jul-05, Volume: 7, Issue:4

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextr

2010
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice.
    BMC complementary and alternative medicine, 2010, Aug-18, Volume: 10

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Drugs, Chinese Herbal; Ethanol; Ga

2010
The role of erythropoietin in the protection of gastric mucosa from indometacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Dose-Response Rel

2010
TLQP-21, a VGF-derived peptide, prevents ethanol-induced gastric lesions: insights into its mode of action.
    Neuroendocrinology, 2010, Volume: 92, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Immunoenzyme

2010
Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E₂, nitric oxide and redox status in indomethacin-induced gastric ulcer model.
    European journal of pharmacology, 2010, Dec-15, Volume: 649, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Capillary Permeability; Dietary

2010
Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms.
    Pharmacological research, 2011, Volume: 63, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce

2011
Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Bismuth; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Synergi

2012
Anti-ulcer and antioxidant activity of GutGard.
    Indian journal of experimental biology, 2010, Volume: 48, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Dose-Response Relationship, Drug; Female; Gastric Acid; Ga

2010
Synthesis, characterization and pharmacological evaluation of 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one: a new anti-inflammatory compound with reduced gastric ulceration properties.
    Molecules (Basel, Switzerland), 2010, Nov-08, Volume: 15, Issue:11

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Movement; Cyclooxygenase 2 Inhibitors; Diclofena

2010
Attenuation of stress-induced gastric lesions by lansoprazole, PD-136450 and ranitidine in rats.
    Molecular and cellular biochemistry, 2011, Volume: 349, Issue:1-2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Animals; Indoles; Indomethacin; Injec

2011
Gastrin-releasing peptide receptor antagonist or N-acetylcysteine combined with omeprazol protect against mitochondrial complex II inhibition in a rat model of gastritis.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 108, Issue:3

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bombesin; Drug

2011
Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine.
    Xenobiotica; the fate of foreign compounds in biological systems, 2011, Volume: 41, Issue:5

    Topics: Administration, Oral; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Blood Proteins;

2011
Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models.
    Journal of ethnopharmacology, 2011, Apr-12, Volume: 134, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Chromatography, High Pressure Liquid; Disease Models, Animal; Ethanol; F

2011
Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.
    Chemico-biological interactions, 2011, Apr-25, Volume: 190, Issue:2-3

    Topics: Animals; Antipsychotic Agents; Capillary Permeability; Dinoprostone; Disease Models, Animal; Dopamin

2011
Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin.
    Journal of pineal research, 2011, Volume: 51, Issue:1

    Topics: Analysis of Variance; Animals; Collagenases; Diabetes Mellitus, Experimental; Drug Interactions; Gel

2011
Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair.
    The American journal of pathology, 2011, Volume: 178, Issue:3

    Topics: Animals; Colony Count, Microbial; Cyclooxygenase 2; Female; Gastric Acid; Gastric Mucosa; Indomethac

2011
Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers.
    Journal of agricultural and food chemistry, 2011, Jun-08, Volume: 59, Issue:11

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Coix; Disease Models, Animal; Humans; Indomethacin; M

2011
Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents.
    Biological research, 2010, Volume: 43, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bromeliaceae; Disease Models, A

2010
Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents.
    Biological research, 2010, Volume: 43, Issue:4

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models,

2010
Curative effect of selenium against indomethacin-induced gastric ulcers in rats.
    Journal of microbiology and biotechnology, 2011, Volume: 21, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Disease Models, An

2011
Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing.
    Free radical research, 2011, Volume: 45, Issue:7

    Topics: Animals; Biflavonoids; Catechin; Cell Adhesion Molecules; Immunoblotting; Indomethacin; Mice; Nitric

2011
Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A

2011
Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Catechin; Disease

2011
Gastroprotective and ulcer-healing mechanisms of ellagic acid in experimental rats.
    Journal of agricultural and food chemistry, 2011, Jul-13, Volume: 59, Issue:13

    Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Cytokines; Dinoprostone; Ellagic Acid; Ethanol; Female; Gas

2011
Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells.
    British journal of pharmacology, 2012, Volume: 165, Issue:4b

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Carrageenan; Cell Line, Tum

2012
Microencapsulation enhances the anti-ulcerogenic properties of Entada africana leaf extract.
    Journal of ethnopharmacology, 2011, Sep-01, Volume: 137, Issue:1

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Capsules; Chemistry, Pharmaceutical; Cytoprotectio

2011
Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antidepressive Agents, Tricycli

2011
Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models.
    Journal of ethnopharmacology, 2011, Sep-01, Volume: 137, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Catalase; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Eth

2011
Anti-ulcerogenic effect of aqueous propolis extract and the influence of radiation exposure.
    International journal of radiation biology, 2011, Volume: 87, Issue:10

    Topics: Animals; Anti-Ulcer Agents; Cytokines; Dinoprostone; Gamma Rays; Gastric Mucosa; Indomethacin; Inter

2011
Incorporation of indomethacin nanoparticles into 3-D ordered macroporous silica for enhanced dissolution and reduced gastric irritancy.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2011, Volume: 79, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Carriers; Drug Com

2011
Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae).
    Journal of ethnopharmacology, 2011, Sep-01, Volume: 137, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gas C

2011
Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action.
    Food & function, 2010, Volume: 1, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Ferment

2010
Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae).
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:9

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Diterpenes; Ethanol; Gastric Acid; Hydrogen-Ion

2011
Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers.
    Journal of pediatric gastroenterology and nutrition, 2012, Volume: 54, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Enzyme-Linked Immunosorbent Assay; Gast

2012
Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress.
    World journal of gastroenterology, 2011, Jul-28, Volume: 17, Issue:28

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Doxycycline; Enzyme Precurs

2011
Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats.
    Free radical biology & medicine, 2011, Nov-01, Volume: 51, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Experimental; Indomethaci

2011
Further evidence of the antiulcer activity of IAC, a novel free radical scavenger.
    Pharmacology, 2011, Volume: 88, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Free Ra

2011
Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling.
    Antioxidants & redox signaling, 2012, Feb-15, Volume: 16, Issue:4

    Topics: Animals; Curcumin; Fibrillar Collagens; Indomethacin; Male; Matrix Metalloproteinase 2; Matrix Metal

2012
The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression.
    Archives of pharmacal research, 2011, Volume: 34, Issue:9

    Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Gastric Mucosa; Gastritis; Indomethacin; Intercellula

2011
ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation.
    Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:3

    Topics: Administration, Oral; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Arteries; Blood

2012
Pharmacological and histological effects of Centaurea bruguierana ssp. belangerana on indomethacin-induced peptic ulcer in rats.
    Journal of natural medicines, 2012, Volume: 66, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Centaurea; Indomethacin; Male; Plant Extracts; Rats; Rats, Wistar; Stoma

2012
[Gastric mucosal susceptibility for ulcerogenic effect of indometacin at different time points of streptozotocin-induced diabetes development].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2011, Volume: 97, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Corticosterone; Diabetes Mellitus,

2011
Comparison of gastric ulcerogenicity of percolated extract of Anacardium occidentale (cashew nut) with indomethacin in rats.
    Pakistan journal of pharmaceutical sciences, 2012, Volume: 25, Issue:1

    Topics: Anacardium; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug

2012
Anti-inflammatory potential of thienopyridines as possible alternative to NSAIDs.
    European journal of pharmacology, 2012, Mar-05, Volume: 678, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Line; Cytokines; Dis

2012
Essential oil of Croton zehntneri and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:3

    Topics: Administration, Oral; Allylbenzene Derivatives; Animals; Anisoles; Brazil; Croton; Disease Models, A

2013
Molecular mechanism of indomethacin-induced gastropathy.
    Free radical biology & medicine, 2012, Apr-01, Volume: 52, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blotting, Western; Cyclooxygenase 2; E

2012
Gastroprotective potential of frutalin, a D-galactose binding lectin, against ethanol-induced gastric lesions.
    Fitoterapia, 2012, Volume: 83, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biomarkers; Capsaicin; Cimetidine; Ethanol; Galactose; Gal

2012
Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2011, Nov-23, Volume: 26, Issue:1

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Cimetidine; Cytoprotection

2011
Antiulcer principle from Zingiber montanum.
    Journal of ethnopharmacology, 2012, May-07, Volume: 141, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Chromatography; Cytoprotection; Disease Models, Animal; Dose-Response Re

2012
Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2012, Volume: 21, Issue:5

    Topics: Animals; Bauhinia; Dose-Response Relationship, Drug; Gastrointestinal Agents; Indomethacin; Male; Me

2012
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
    Pharmacological research, 2012, Volume: 65, Issue:5

    Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experiment

2012
Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb.
    Journal of ethnopharmacology, 2012, May-07, Volume: 141, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Calophyllum; Catalase; Chemical Fractionation; Chromatography, High Pres

2012
Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice.
    European journal of pharmacology, 2012, May-15, Volume: 683, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Cyclooxygenase 2; Disease Models

2012
Protective effect of Chresta martii extract against indomethacin-induced gastric lesions in mice.
    Journal of natural medicines, 2013, Volume: 67, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Asteraceae; Flowers; Indomethacin; Male; Mice; Plant Extracts; Plant Lea

2013
Curcumin prevents indomethacin-induced gastropathy in rats.
    World journal of gastroenterology, 2012, Apr-07, Volume: 18, Issue:13

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Endothelial Cells; Gastric Mucosa; Indom

2012
Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.
    Pharmacology, 2012, Volume: 89, Issue:5-6

    Topics: Animals; Anti-Inflammatory Agents; Bethanechol; Disease Models, Animal; Guanidines; Histamine Agonis

2012
[Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytoprotection; D

2012
Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action.
    Journal of natural medicines, 2013, Volume: 67, Issue:1

    Topics: Alcohols; Animals; Glutathione Peroxidase; Hydroxyl Radical; Indomethacin; Lipid Peroxidation; Malon

2013
Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation.
    Acta biochimica et biophysica Sinica, 2012, Volume: 44, Issue:7

    Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors

2012
Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice.
    Journal of natural medicines, 2013, Volume: 67, Issue:2

    Topics: Acrolein; Animals; Anti-Ulcer Agents; Aspirin; Cinnamomum zeylanicum; Disease Models, Animal; Drugs,

2013
Antiulcerogenic effect of Croton urucurana Baillon bark.
    Journal of ethnopharmacology, 2012, Aug-30, Volume: 143, Issue:1

    Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Croton; Disease Models, Animal; Ethanol; Female; Gastric Ac

2012
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
    European journal of pharmacology, 2012, Sep-15, Volume: 691, Issue:1-3

    Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine

2012
High sensitivity of gastric mucosa to ulcerogenic effect of indomethacin in rats with diabetes.
    Bulletin of experimental biology and medicine, 2011, Volume: 152, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental

2011
Effect of HMG-CoA-reductase inhibitor on DNA synthesis and free radical oxidation in the gastric mucosa under normal conditions and during indometacin-induced ulcerative process in the stomach of albino mice.
    Bulletin of experimental biology and medicine, 2012, Volume: 152, Issue:3

    Topics: Animals; Autoradiography; DNA Replication; Free Radicals; Gastric Mucosa; Hydroxymethylglutaryl-CoA

2012
Gastroprotection of suaveolol, isolated from Hyptis suaveolens, against ethanol-induced gastric lesions in Wistar rats: role of prostaglandins, nitric oxide and sulfhydryls.
    Molecules (Basel, Switzerland), 2012, Jul-26, Volume: 17, Issue:8

    Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Cyclooxygenase Inhibitors; Ethanol; Ethylmaleimide; Hypti

2012
Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance.
    European journal of medicinal chemistry, 2012, Volume: 57

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationshi

2012
Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capsaicin; Dose-Response

2012
DL-trans-3,4-dihydroxy-1-selenolane (DHS(red)) accelerates healing of indomethacin-induced stomach ulceration in mice.
    Free radical research, 2012, Volume: 46, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Heterocyclic Compounds, 1-Ring; Immu

2012
Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats.
    Immunopharmacology and immunotoxicology, 2012, Volume: 34, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antioxidants; Benzimidazo

2012
Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.
    Journal of medicinal food, 2012, Volume: 15, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonic Acid; Cymenes; Edema; Female; Indo

2012
Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf.
    Pharmaceutical biology, 2012, Volume: 50, Issue:12

    Topics: Animals; Anti-Ulcer Agents; Bauhinia; Chloroform; Chromatography, High Pressure Liquid; Cytoprotecti

2012
Chronic gastric ulceration causes matrix metalloproteinases-9 and -3 augmentation: alleviation by melatonin.
    Biochimie, 2012, Volume: 94, Issue:12

    Topics: Animals; Antioxidants; Blotting, Western; Chronic Disease; Extracellular Signal-Regulated MAP Kinase

2012
A study on the protective activity of kefir against gastric ulcer.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2012, Volume: 23, Issue:4

    Topics: Animals; Cultured Milk Products; Gastric Mucosa; Indomethacin; Male; Mucus; Rats; Rats, Wistar; Stat

2012
Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury.
    European journal of pharmacology, 2012, Dec-15, Volume: 697, Issue:1-3

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cytoprotection; Dinoprostone; Disease Models, Anim

2012
Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. St.-Hil. (Lytraceae) in experimental animals.
    Journal of ethnopharmacology, 2012, Dec-18, Volume: 144, Issue:3

    Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Brazil; Ethanol; Gastrointestinal Transit; Indomethacin; In

2012
[A comparative analysis of corticosterone, cortisol and dexametasone effects on gastric erosion in rats].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2012, Volume: 98, Issue:7

    Topics: Animals; Blood Glucose; Corticosterone; Dexamethasone; Disease Models, Animal; Hydrocortisone; Indom

2012
Effects of statins in an indomethacin-induced gastric injury model in rats.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2012, Volume: 23, Issue:5

    Topics: Animals; Disease Models, Animal; Gastric Mucosa; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ind

2012
Homopterocarpin contributes to the restoration of gastric homeostasis by Pterocarpus erinaceus following indomethacin intoxication in rats.
    Asian Pacific journal of tropical medicine, 2013, Volume: 6, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzofurans; Benzopyrans; Cimet

2013
Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dose-Respons

2002
The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats.
    Phytotherapy research : PTR, 2002, Volume: 16, Issue:5

    Topics: Acetone; Administration, Oral; Animals; Anti-Ulcer Agents; Disease Models, Animal; Fabaceae; Gastric

2002
Aggravation of nonsteroidal antiinflammatory drug gastropathy by glucocorticoid deficiency or blockade of glucocorticoid receptors in rats.
    Life sciences, 2002, Oct-11, Volume: 71, Issue:21

    Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Corticosterone; Drug Syner

2002
Mechanisms by which endogenous glucocorticoid protects against indomethacin-induced gastric injury in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:5

    Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Capillary Permeabili

2002
Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Animals; Arthritis, Experimental; Capillary Permeability; Celecoxib; Cyclooxygenase 1; Cyclooxygenas

2002
Possible mechanism underlying the effect of Semax on the formation of indomethacin-induced ulcers in rats.
    Bulletin of experimental biology and medicine, 2002, Volume: 133, Issue:6

    Topics: Adrenocorticotropic Hormone; Animals; Anti-Ulcer Agents; Indomethacin; Male; Peptide Fragments; Rats

2002
Antinociceptive and gastroprotective effects of diterpenes from the flower buds of Egletes viscosa.
    Planta medica, 2002, Volume: 68, Issue:11

    Topics: Acetic Acid; Analgesics; Animals; Anti-Ulcer Agents; Asteraceae; Diterpenes; Dose-Response Relations

2002
Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat.
    Life sciences, 2002, Dec-27, Volume: 72, Issue:6

    Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Dru

2002
Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats.
    Digestion, 2002, Volume: 66, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Duodenal Ulcer; Enzyme

2002
Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2002, Volume: 54, Issue:3

    Topics: Animals; Aspirin; Carbohydrates; Ethanol; Female; Fructose; Glucose; Honey; Indomethacin; Male; Malt

2002
[Pharmacological studies of shundao granules on gastrointestinal track].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 1998, Volume: 21, Issue:8

    Topics: Analgesics; Animals; Anti-Ulcer Agents; Constipation; Drugs, Chinese Herbal; Female; Gastric Acid; G

1998
Effect of amitriptyline on gastric ulceration.
    Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:4

    Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Aspirin; Col

2002
[Synthesis, preliminary antigastrelcosis activity and the protective effect on acute liver injury of zinc chlorin E4].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2001, Volume: 36, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury;

2001
Protective effects of steroid saponins from Paris polyphylla var. yunnanensis on ethanol- or indomethacin-induced gastric mucosal lesions in rats: structural requirement for activity and mode of action.
    Bioorganic & medicinal chemistry letters, 2003, Mar-24, Volume: 13, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carbohydrate Sequence; Ethanol;

2003
Protective effects of polygodial on gastric mucosal lesions induced by necrotizing agents in rats and the possible mechanisms of action.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:5

    Topics: Animals; Aspirin; Ethanol; Gastric Mucosa; Gastrointestinal Agents; Hydrochloric Acid; Indomethacin;

2003
Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin.
    Canadian journal of physiology and pharmacology, 2003, Volume: 81, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Chemistry, Pharmaceutical; Cimetidine; Cyclodextrins; D

2003
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs].
    Terapevticheskii arkhiv, 2003, Volume: 75, Issue:5

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodeno

2003
Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing.
    Digestion, 2003, Volume: 67, Issue:3

    Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Cell Division; Ce

2003
A new furoxan NO-donor rabeprazole derivative and related compounds.
    Chembiochem : a European journal of chemical biology, 2003, Sep-05, Volume: 4, Issue:9

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Drug Design; He

2003
Anti-inflammatory and antiulcerogenic effects of the aqueous extract of Lobaria pulmonaria (L.) Hoffm.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2003, Volume: 10, Issue:6-7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Beverages; Carrageenan; Edema;

2003
[ON THE GASTRO-LESIONAL EFFECT OF INDOMETHACIN].
    Archivio "E. Maragliano" di patologia e clinica, 1964, Volume: 20

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Indoles; Indomethacin; Peptic Ulcer Perforation;

1964
Differences between gastric antiulcer effects of trapencaine enantiomers.
    Die Pharmazie, 2003, Volume: 58, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carbamates; Central Nervous Sys

2003
Synthesis and anti-inflammatory activity of alkyl/arylidene-2-aminobenzothiazoles and 1-benzothiazol-2-yl-3-chloro-4-substituted-azetidin-2-ones.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azetidines; Carrageenan; Chemical Phenomena; Chemi

2003
Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2003, Volume: 54, Issue:3

    Topics: Acetic Acid; Animals; Dinoprostone; Disease Models, Animal; Drug Administration Schedule; Fibrosis;

2003
Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats.
    Phytotherapy research : PTR, 2003, Volume: 17, Issue:10

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Caffeine; Dose-Response Relationship, Drug; Ethano

2003
Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum.
    The American journal of Chinese medicine, 2003, Volume: 31, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Hydrochloric Acid; Hypo

2003
Effects of Azadirachta indica extract on gastric ulceration and acid secretion in rats.
    Journal of ethnopharmacology, 2004, Volume: 90, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Azadirachta; Cimetidine; Drug Therapy, Combination; Gastric Acid; Histam

2004
Methimazole prevents stress and chemical induced gastropathy in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2003, Volume: 55, Issue:4

    Topics: Animals; Antithyroid Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Fema

2003
Expression of urokinase-type plasminogen activator and its receptor in gastric fibroblasts and effects of nonsteroidal antiinflammatory drugs and prostaglandin.
    Digestive diseases and sciences, 2003, Volume: 48, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens; Cells, Cultured; Dinoprostone; DNA Primers; Dose-

2003
[Deficiency of glucocorticoid production delays the healing of acute gastric mucosal erosion and chronic ulcers in rats].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2003, Volume: 89, Issue:9

    Topics: Acetic Acid; Adrenalectomy; Animals; Chronic Disease; Corticosterone; Gastric Mucosa; Glucocorticoid

2003
Effect of adrenalectomy on healing of indomethacin-induced gastric erosions in rats.
    Bulletin of experimental biology and medicine, 2003, Volume: 136, Issue:5

    Topics: Adrenalectomy; Animals; Corticosterone; Gastric Mucosa; Glucocorticoids; Indomethacin; Rats; Rats, S

2003
Parietal cell density during gastric ulcer healing in the rat.
    Scandinavian journal of gastroenterology, 2004, Volume: 39, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Count; Female; Helicobacte

2004
Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA.
    Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bethanechol; Cimetidine; Diseas

2004
New amides and gastroprotective constituents from the fruit of Piper chaba.
    Planta medica, 2004, Volume: 70, Issue:2

    Topics: Amides; Animals; Anti-Ulcer Agents; Ethanol; Fruit; Indomethacin; Phytotherapy; Piperaceae; Plant Ex

2004
Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats.
    Die Pharmazie, 2004, Volume: 59, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Depressants; Cyclooxygenase

2004
Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents.
    European journal of medicinal chemistry, 2004, Volume: 39, Issue:3

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; G

2004
Roles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:1 Pt 2

    Topics: Administration, Oral; Animals; Body Weight; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyg

2004
Effects of indomethacin and rofecoxib on gastric mucosal damage in normal and Helicobacter pylori-infected mongolian gerbils.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:1 Pt 2

    Topics: Administration, Oral; Animals; Dinoprostone; Drug Administration Schedule; Drug Synergism; Gastric A

2004
Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.
    Digestive diseases and sciences, 2004, Volume: 49, Issue:2

    Topics: Animals; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinopro

2004
Mg,Al layered double hydroxides with intercalated indomethacin: synthesis, characterization, and pharmacological study.
    Journal of pharmaceutical sciences, 2004, Volume: 93, Issue:6

    Topics: Aluminum Hydroxide; Animals; Drug Combinations; Female; Gastric Mucosa; Indomethacin; Magnesium Hydr

2004
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Cysteamine; Duodenal

2004
Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce

2004
[Prophylactic use of angiotensin-converting enzyme inhibitors in indomethacin-induced ulcer and erosion lesions of the stomach].
    Likars'ka sprava, 2004, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthriti

2004
Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats.
    Indian journal of experimental biology, 2003, Volume: 41, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Cissampelos; Female; Indomethacin; Male; Methanol; Phytotherapy; Plant E

2003
Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia.
    Journal of ethnopharmacology, 2004, Volume: 94, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Cimetidine; Female; Indomethacin;

2004
Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine.
    Inflammopharmacology, 2004, Volume: 12, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Therapy, Combination; Edema; Indo

2004
Enhancement in the absorption of water and electrolytes from rat intestine by Hemidesmus indicus R. Br. root (water extract).
    Phytotherapy research : PTR, 2004, Volume: 18, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Electrolytes; Female; Gastrointestinal

2004
The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2004, Volume: 11, Issue:5

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Gastric

2004
Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin.
    Journal of medicinal food, 2004,Fall, Volume: 7, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cattle; Cimetidine; Disease Mod

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
    Life sciences, 2004, Nov-26, Volume: 76, Issue:2

    Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani

2004
Effect of Manilkara hexandra (Roxb.) Dubard against experimentally-induced gastric ulcers.
    Phytotherapy research : PTR, 2004, Volume: 18, Issue:10

    Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Female; Indomethacin; Ligatio

2004
Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat.
    Peptides, 2004, Volume: 25, Issue:12

    Topics: Animals; Ethanol; Gastric Mucosa; Ghrelin; Indomethacin; Injections, Intraventricular; Injections, S

2004
Antiulcer activity of methanol fraction of Barleria lupulina Lindl. in animal models.
    Phytotherapy research : PTR, 2004, Volume: 18, Issue:11

    Topics: Acanthaceae; Animals; Anti-Ulcer Agents; Duodenal Ulcer; Ethanol; Female; Gastric Mucosa; Indomethac

2004
Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils.
    World journal of gastroenterology, 2005, Jan-07, Volume: 11, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Chronic Diseas

2005
Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer.
    The Journal of biological chemistry, 2005, Mar-11, Volume: 280, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Disease Models, Animal; Gastric Mucosa;

2005
Survivin: a novel target for indomethacin-induced gastric injury.
    Gastroenterology, 2005, Volume: 128, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Culture Techniques; Cyclooxygenase

2005
Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives.
    Archiv der Pharmazie, 2005, Volume: 338, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Evaluation, Preclinical; Edema;

2005
Protective effect of ketoconazole against experimentally induced gastric ulcers in rats.
    Research communications in molecular pathology and pharmacology, 2003, Volume: 113-114

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Ethanol; Female; Immunologic Fa

2003
Is gastric ulceration different in normal and malnourished rats?
    The British journal of nutrition, 2005, Volume: 93, Issue:1

    Topics: Acetic Acid; Animals; Body Weight; Corticosterone; Cytoprotection; Dinoprostone; Ethanol; Female; Ga

2005
Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers.
    Chemical research in toxicology, 2005, Volume: 18, Issue:2

    Topics: Animals; Choline; Glucose; Glycerylphosphorylcholine; Indomethacin; Lactic Acid; Male; Nuclear Magne

2005
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
    Indian journal of experimental biology, 2005, Volume: 43, Issue:3

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indom

2005
Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Colony Count, Microbial; Cyclooxygenase

2005
Therapeutic effect of D-002 (abexol) on gastric ulcer induced experimentally in rats.
    Journal of medicinal food, 2005,Spring, Volume: 8, Issue:1

    Topics: Acetic Acid; Acute Disease; Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Chronic

2005
Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa.
    Medicina (Kaunas, Lithuania), 2005, Volume: 41, Issue:4

    Topics: Animals; Gastric Mucosa; Glutathione; Helicobacter Infections; Helicobacter pylori; Indomethacin; Li

2005
Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2005, Volume: 56, Issue:6

    Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Dose-Response Relat

2005
Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw.
    Journal of ethnopharmacology, 2005, Oct-03, Volume: 101, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Capillary Permeability; Casearia; Indomethacin

2005
Protective role of heat shock protein 27 in gastric mucosal injury.
    The Journal of pathology, 2005, Volume: 207, Issue:2

    Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2;

2005
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
    TheScientificWorldJournal, 2005, Aug-08, Volume: 5

    Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin;

2005
Preliminary evaluation on anti-inflammatory and analgesic effects of Sideritis syriaca L. herba extracts.
    Journal of medicinal food, 2005,Summer, Volume: 8, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biological Assay; Gastric Mucosa; Indomethacin; Male;

2005
Effect of melatonin on secreted and induced matrix metalloproteinase-9 and -2 activity during prevention of indomethacin-induced gastric ulcer.
    Journal of pineal research, 2005, Volume: 39, Issue:3

    Topics: Animals; Enzyme Induction; Indomethacin; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase

2005
Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.
    Pharmacology, 2005, Volume: 75, Issue:3

    Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal;

2005
Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats.
    Journal of ethnopharmacology, 2006, Jan-03, Volume: 103, Issue:1

    Topics: Animals; Antioxidants; Benzofurans; Cytoprotection; Gastric Mucosa; Glutathione Peroxidase; Indometh

2006
Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2005, Volume: 12, Issue:9

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Dose-Response Relationship, Drug; Glutathione Tr

2005
Importance of the pineal gland, endogenous prostaglandins and sensory nerves in the gastroprotective actions of central and peripheral melatonin against stress-induced damage.
    Journal of pineal research, 2005, Volume: 39, Issue:4

    Topics: Administration, Topical; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Ventricles; C

2005
Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer model in rats.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2005, Volume: 16, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fats, Unsaturated; D

2005
Modulation of gastric hemorrhage and ulceration by oxidative stress and histamine release in Salmonella typhimurium-infected rats.
    Inflammopharmacology, 2005, Volume: 13, Issue:1-3

    Topics: Allopurinol; Animals; Antioxidants; Dimethyl Sulfoxide; Disease Models, Animal; Gastric Juice; Gastr

2005
Agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma): a new compound with potent gastroprotective and ulcer healing properties.
    Inflammopharmacology, 2005, Volume: 13, Issue:1-3

    Topics: Animals; Anti-Ulcer Agents; Blood Flow Velocity; Blotting, Western; Dinoprostone; Dose-Response Rela

2005
Cell proliferation in the gastric epithelium of the ulcer rat.
    Scandinavian journal of gastroenterology, 2005, Volume: 40, Issue:12

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Epithelial Cells;

2005
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.
    Bioorganic & medicinal chemistry, 2006, Mar-15, Volume: 14, Issue:6

    Topics: Amides; Analgesics; Animals; Anti-Inflammatory Agents; Drug Evaluation, Preclinical; Female; Indomet

2006
Bioactive saponins and glycosides. XXIII. Triterpene saponins with gastroprotective effect from the seeds of Camellia sinensis--theasaponins E3, E4, E5, E6, and E7.
    Chemical & pharmaceutical bulletin, 2005, Volume: 53, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Camellia; Carbohydrate Sequence

2005
Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Electron Spin Resonance Spectroscopy; Indomethacin

2006
Nonsteroidal antiinflammatory agents-part 2 antiinflammatory, analgesic and antipyretic activity of some substituted 3-pyrazolin-5-ones and 1,2,4,5,6,7-3H-hexahydroindazol-3-ones.
    European journal of medicinal chemistry, 2006, Volume: 41, Issue:2

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ed

2006
Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:1

    Topics: Animals; Catalase; Flavonoids; Garcinia kola; Gastric Mucosa; Glutathione; Hydrochloric Acid; Incide

2006
Acetazolamide interferes with the protective effect of prostaglandin E2 in the rat gastric mucosa.
    Scandinavian journal of gastroenterology, 1981, Volume: 16, Issue:3

    Topics: Acetazolamide; Alkalies; Animals; Carbonic Anhydrase Inhibitors; Cyclooxygenase Inhibitors; Dinopros

1981
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In

2006
Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?
    Digestion, 2006, Volume: 73, Issue:1

    Topics: Analysis of Variance; Animals; Collagen; Granulation Tissue; Hydroxyproline; Immunohistochemistry; I

2006
Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats.
    Autonomic neuroscience : basic & clinical, 2006, Jun-30, Volume: 126-127

    Topics: Acetic Acid; Adrenal Glands; Animals; Anti-Inflammatory Agents, Non-Steroidal; Consciousness; Cortic

2006
Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors.
    Bioorganic & medicinal chemistry, 2006, Jul-15, Volume: 14, Issue:14

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation,

2006
Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen.
    Free radical biology & medicine, 2006, Apr-15, Volume: 40, Issue:8

    Topics: Acids; Animals; Biomarkers; Curcumin; Electron Spin Resonance Spectroscopy; Enzyme Activation; Gastr

2006
Gastroprotective effect of a traditional Chinese herbal drug "Baishouwu" on experimental gastric lesions in rats.
    Journal of ethnopharmacology, 2006, Oct-11, Volume: 107, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Apocynaceae; China; Cynanchum; Drugs, Chinese Herbal; Ethanol; Ethnobota

2006
Chronic paroxysmal hemicrania, hemicrania continua and SUNCT: the fate of the three first described cases.
    The journal of headache and pain, 2006, Volume: 7, Issue:3

    Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Headache; Humans; Indomethacin;

2006
[Angiotensin II AT1 receptor antagonists as antiinflammatory and gastric protection drugs].
    Acta gastroenterologica Latinoamericana, 2006, Volume: 36, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Benzimidazoles; Biphenyl

2006
The inhibition of gastric mucosal lesion, oxidative stress and neutrophil-infiltration in rats by the lichen constituent diffractaic acid.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2006, Volume: 13, Issue:8

    Topics: Animals; Anisoles; Antioxidants; Gastric Mucosa; Glutathione; Hydroxybenzoates; Indomethacin; Lipid

2006
Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants.
    Free radical biology & medicine, 2006, Sep-15, Volume: 41, Issue:6

    Topics: Animals; Antioxidants; Collagenases; Disease Models, Animal; DNA Primers; Enzyme Precursors; Gene Ex

2006
Mechanisms involved in the gastro-protective effect of STW 5 (Iberogast) and its components against ulcers and rebound acidity.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2006, Volume: 13 Suppl 5

    Topics: Animals; Gastric Acidity Determination; Gastric Juice; Gastrins; Indomethacin; Male; Phytotherapy; P

2006
Prostaglandins, capsaicin-sensitive sensory nerves and neutrophil infiltration, but not nitric oxide, contribute to cold restraint stress-induced gastric adaptation in rats.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:10

    Topics: Acclimatization; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cold Temperature; Dinoprostone

2006
Sustained-release tablets of indomethacin-loaded microcapsules: preparation, in vitro and in vivo characterization.
    International journal of pharmaceutics, 2007, Mar-21, Volume: 333, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents; Area Under Curve; Biological Availability; Calorimetry, Different

2007
Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs.
    Journal of veterinary pharmacology and therapeutics, 2006, Volume: 29, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Duodenoscopy; Duodenum; Gastrointestinal Mot

2006
Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation.
    Journal of controlled release : official journal of the Controlled Release Society, 2006, Dec-01, Volume: 116, Issue:3

    Topics: Acrylic Resins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Carr

2006
Effect of Brazilian green propolis on experimental gastric ulcers in rats.
    Journal of ethnopharmacology, 2007, Apr-04, Volume: 110, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Brazil; Complex Mixtures; Disease Models, Animal; Dose-Response Relation

2007
Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats.
    World journal of gastroenterology, 2006, Nov-28, Volume: 12, Issue:44

    Topics: Adrenergic Agents; Amphetamine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male

2006
Antisecretory and antiulcer activity of Asparagus racemosus Willd. against indomethacin plus phyloric ligation-induced gastric ulcer in rats.
    Journal of herbal pharmacotherapy, 2006, Volume: 6, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Asparagus Plant; Dose-Response

2006
Gastric microcirculation as target of gastroprotective action of glucocorticoid hormones in rats with desensitization of capsaicin-sensitive sensory neurons.
    Inflammopharmacology, 2006, Volume: 14, Issue:5-6

    Topics: Adrenalectomy; Animals; Capsaicin; Gastric Mucosa; Glucocorticoids; Indomethacin; Male; Microcircula

2006
[Experimental study of the impact of a single use of indometacine on the morphological structure of the mucous coat of the stomach and small intestine].
    Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2006, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enteritis; Gastric Mucosa; Indomethacin; Intestina

2006
Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Anti-Ulcer Agents; Arachidonic Acids; Calcitonin

2007
[Compensatory gastroprotective action of glucocorticoid hormones in the rats with ablation of capsaicin-sensitive neurons].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2006, Volume: 92, Issue:8

    Topics: Adrenalectomy; Animals; Capsaicin; Corticosterone; Gastric Mucosa; Indomethacin; Male; Neurons; Rats

2006
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
    Pharmacological research, 2007, Volume: 55, Issue:5

    Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani

2007
Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:3

    Topics: Adrenalectomy; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; alpha-

2007
Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers.
    World journal of gastroenterology, 2007, Feb-21, Volume: 13, Issue:7

    Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Mucosa; Indomethac

2007
The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments.
    Annals of the New York Academy of Sciences, 2007, Volume: 1095

    Topics: Analgesics; Animals; Indomethacin; Iran; Male; Medicine, Traditional; Mice; Phytotherapy; Plant Extr

2007
Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:11

    Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Centra

2007
Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:8

    Topics: Acetic Acid; Alendronate; Animals; Bone Density Conservation Agents; Cells, Cultured; Cyclooxygenase

2007
Evaluation of the anti-ulcerogenic effect of sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis by using various in vivo and biochemical techniques.
    Journal of ethnopharmacology, 2007, Jun-13, Volume: 112, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Behavior, Animal; Centaurea; Dose-Response Relationship, Drug; Enzyme In

2007
The effect of nonsteroidal anti-inflammatory drugs on rat gastric mucosa. The role of endothelin.
    Saudi medical journal, 2007, Volume: 28, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bosentan; Endothelin Receptor Antagonists; Endothe

2007
Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats.
    Fundamental & clinical pharmacology, 2007, Volume: 21, Issue:3

    Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Bezafibrate; Ethanol; Gastric Acid; Gastric Mucosa; Indomet

2007
Effect of (S)-4-(1-(5-chloro-2-(4-fluorophenyoxy)benzamido)ethyl) benzoic acid (CJ-42794), a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:3

    Topics: Animals; Benzamides; Benzoates; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lactones; Peptic Ul

2007
Influence of DL-alpha-tocopherol acetate on indomethacin-induced gastric mucosal injury in rats.
    Autonomic & autacoid pharmacology, 2007, Volume: 27, Issue:3

    Topics: alpha-Tocopherol; Animals; Antioxidants; Gastric Mucosa; Glutathione; Glutathione Disulfide; Indomet

2007
Gastric antisecretory and antiulcer effects of simvastatin in rats.
    Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:12

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Ethanol; Female; Gastric Acid; Gastric Mucosa; Indomethaci

2007
Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng.
    Chemical & pharmaceutical bulletin, 2007, Volume: 55, Issue:7

    Topics: Animals; Dammaranes; Disease Models, Animal; Ethanol; Flowers; Gastrointestinal Agents; Glycosides;

2007
Antinociceptive and anti-inflammatory steroidal saponins from Dracaena ombet.
    Planta medica, 2007, Volume: 73, Issue:10

    Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-

2007
Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models.
    Journal of ethnopharmacology, 2007, Sep-05, Volume: 113, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Brazil; Cimetidine; Disease Mod

2007
Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action.
    World journal of gastroenterology, 2007, Jul-21, Volume: 13, Issue:27

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Catechols; Disease Models, Animal; DNA; Gastric

2007
Cytoprotective effects of Bergenia ciliata Sternb, extract on gastric ulcer in rats.
    Phytotherapy research : PTR, 2007, Volume: 21, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cytoprotection; Ethanol; Hydroc

2007
Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study.
    Folia medica, 2006, Volume: 48, Issue:3-4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnitine; Chemoprevention;

2006
Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+,K+ -ATPase activity and formation of nitric oxide.
    Journal of ethnopharmacology, 2007, Sep-25, Volume: 113, Issue:3

    Topics: Acetic Acid; Animals; Female; Flavonoids; Gastric Acid; Gastric Juice; Gastric Mucosa; Glutathione;

2007
Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin.
    British journal of pharmacology, 2007, Volume: 152, Issue:6

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Biotransfo

2007
Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Animals; Anti-Ulcer Agents; Antioxidants; Catalas

2007
Gastroprotective activity of the hydroalcoholic extract obtained from Polygala paniculata L. in rats.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:10

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Brazil; Colorimetry; Dose-Response Relationship, Drug; Eth

2007
Modulation of indomethacin-induced gastric injury by spermine and taurine in rats.
    Journal of biochemical and molecular toxicology, 2007, Volume: 21, Issue:5

    Topics: Animals; Gastric Mucosa; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Indomethacin; M

2007
Gastroprotective effect of mangiferin, a xanthonoid from Mangifera indica, against gastric injury induced by ethanol and indomethacin in rodents.
    Planta medica, 2007, Volume: 73, Issue:13

    Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Hydrogen-Ion Co

2007
Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:11

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug;

2007
Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2008, Volume: 15, Issue:5

    Topics: Animals; Arginine; Capsaicin; Diazoxide; Dose-Response Relationship, Drug; Ethanol; Glyburide; Indom

2008
Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action.
    European journal of pharmacology, 2008, Jan-14, Volume: 578, Issue:2-3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease

2008
The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2007, Volume: 13, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease M

2007
Anti-ulcer, anti-inflammatory and antioxidant activities of the n-butanol fraction from Pteleopsis suberosa stem bark.
    Journal of ethnopharmacology, 2008, Jan-17, Volume: 115, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Combretaceae; Dose-Response Rela

2008
Effects of progesterone on FSH-stimulated indomethacin ulcers in rats.
    Fertility and sterility, 2008, Volume: 90, Issue:5

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogens; Female; Follicle Stimu

2008
Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration.
    Pharmaceutical research, 2008, Volume: 25, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell P

2008
Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats.
    Archives of pharmacal research, 2007, Volume: 30, Issue:11

    Topics: Amiodarone; Animals; Antioxidants; Gastric Mucosa; Glutathione; Glutathione Transferase; Indomethaci

2007
Anti-ulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice.
    Journal of medicinal food, 2007, Volume: 10, Issue:4

    Topics: Analgesia; Analgesics; Animals; Bethanechol; Crassulaceae; Flavonoids; Gastric Juice; Hydrochloric A

2007
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
    Acta pharmaceutica (Zagreb, Croatia), 2007, Volume: 57, Issue:4

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An

2007
Annexin-1 modulates repair of gastric mucosal injury.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:3

    Topics: Animals; Annexin A1; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dexamethasone; Dose

2008
Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration.
    BMC complementary and alternative medicine, 2008, Jan-31, Volume: 8

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Dinoprostone; Dose-Response Relationship, Drug; Ep

2008
Gastroprotective effect of a flavone from Lonchocarpus araripensis Benth. (Leguminosae) and the possible mechanism.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Derris; Dose-Response Relationship, Drug; Ethanol; Flavones; Gastric Muc

2008
Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2008, Volume: 22, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aortic Diseases; Fatal Outcome; Fundoplication; Gastric Fis

2008
The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2008, Volume: 15, Issue:6-7

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Boswellia; Ethanol; Hot Temperature; Hydrochloric Acid; Indomet

2008
Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:11

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catechols; Cyclooxygenase 1; Cyclooxygenase 2; Dinoproston

2008
Life-threatening illness in those with severe mental handicap.
    Lancet (London, England), 1981, May-16, Volume: 1, Issue:8229

    Topics: Female; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Peptic Ulcer Perforation;

1981
The effect of stress and indomethacin, carbenoxolone, salbutamol, metiamide, zolimidine and CF19415 on rat gastric mucus.
    The Journal of pharmacy and pharmacology, 1981, Volume: 33, Issue:6

    Topics: Acetonitriles; Albuterol; Animals; Anti-Ulcer Agents; Carbenoxolone; Gastric Mucosa; Indomethacin; M

1981
Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent.
    The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Butanones; F

1982
The effect of levamisole on gastric ulcers induced in the rat by anti-inflammatory and necrotizing agents.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Ethanol; Hydrochloric Acid; Indomethacin; Leva

1984
Do prostaglandins mediate the somatostatin preventive effect on gastric lesion?
    Experientia, 1984, Sep-15, Volume: 40, Issue:9

    Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Male; Prostaglandins; Rats

1984
[Effect of prostaglandin E1 on gastric mucin secretin and acute mucosal lesions in rat (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1980, Volume: 77, Issue:11

    Topics: Acute Disease; Animals; Cold Temperature; Gastric Mucins; Gastric Mucosa; Indomethacin; Male; Prosta

1980
Ulceration induced by an endoperoxide analog and by indomethacin in the canine stomach.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1983, Volume: 12

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Dogs; Gastric Mucosa; I

1983
Gastric mucosal prostaglandin generation in rats with stress ulcer.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1983, Volume: 12

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cold Temperature; Gastric Mucosa; Humans; Indomethacin; Male;

1983
The relationships between indomethacine-induced gastric ulcer, ulcer protection by cimetidine and prostacyclin and the cAMP system of the gastric fundic mucosa in the rat.
    Acta physiologica Academiae Scientiarum Hungaricae, 1982, Volume: 60, Issue:3

    Topics: Animals; Cimetidine; Cyclic AMP; Epoprostenol; Female; Gastric Fundus; Gastric Mucosa; Guanidines; I

1982
Inhibition of PG production by MDL 035, a new non-steroidal non-acidic anti-inflammatory compound, in rat gastric mucosa and inflammatory exudate.
    Pharmacological research communications, 1984, Volume: 16, Issue:8

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoproston

1984
Gastric antral ulcers produced by the combined administration of indomethacin with 2-deoxy-D-glucose in the rat.
    European journal of pharmacology, 1983, May-06, Volume: 89, Issue:3-4

    Topics: Animals; Deoxy Sugars; Deoxyglucose; Drug Interactions; Gastric Acid; Indomethacin; Insulin; Male; P

1983
Cytoprotection and 6-keto-prostaglandin-F1 alpha.
    Acta physiologica Hungarica, 1983, Volume: 61, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dose-Response Relationship, Drug; Epoprostenol; Female; Gastr

1983
Prevention of gastric mucosal lesions in rats by tri-potassium di-citrato bismuthate.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Bismuth; Epoprostenol; Ethanol; Gastric Mucosa; Indomethacin; Male; Orga

1984
Stimulation of gastric prostaglandin synthesis by refeeding in the rat. Role in protection of gastric mucosa from damage.
    Digestive diseases and sciences, 1984, Volume: 29, Issue:4

    Topics: Animals; Aspirin; Dinoprost; Eating; Epoprostenol; Evaluation Studies as Topic; Female; Gastric Muco

1984
Prostacyclin and DNA-synthesis inhibitors: their interaction on experimental gastric ulcer in the rat.
    Acta medica Hungarica, 1984, Volume: 41, Issue:4

    Topics: Animals; Cytarabine; DNA; Epoprostenol; Female; Indomethacin; Rats; Rats, Inbred Strains; Stomach Ul

1984
Prostaglandin content in the rat gastric mucosa during healing of chronic ulcers induced by acetic acid.
    Agents and actions, 1983, Volume: 13, Issue:2-3

    Topics: Acetates; Animals; Carbonic Anhydrases; Gastric Mucosa; Indomethacin; Male; Prostaglandins; Rats; Ra

1983
Enhancement by intracerebroventricular thyrotropin-releasing hormone of indomethacin-induced gastric lesions in the rat.
    British journal of pharmacology, 1983, Volume: 80, Issue:4

    Topics: Animals; Drug Interactions; Gastric Acid; Gastric Juice; Gastric Mucosa; Indomethacin; Injections, I

1983
M&B 28,767: a potent anti-secretory and anti-ulcer PG analogue. A comparative study with 16, 16' dimethyl PGE2 methylester.
    Life sciences, 1984, Dec-17, Volume: 35, Issue:25

    Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Constipation; Diarrhea; Gastric Acid; Gastroin

1984
[Nitrogenous triterpene derivatives. 9. 3-Acetyloleanol acid-28-amides and their antiulcer effect].
    Die Pharmazie, 1984, Volume: 39, Issue:10

    Topics: Animals; Anti-Ulcer Agents; Chemical Phenomena; Chemistry; Indomethacin; Male; Rats; Stomach Ulcer;

1984
Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat.
    Acta physiologica Hungarica, 1984, Volume: 64, Issue:3-4

    Topics: Animals; Drug Combinations; Ethanol; Female; Gastric Mucosa; Indomethacin; Intestinal Diseases; Inte

1984
Evidence for the existence of gastric cytoprotective effect of atropine and cimetidine in humans.
    Acta physiologica Hungarica, 1984, Volume: 64, Issue:3-4

    Topics: Adult; Atropine; Cimetidine; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastric Mucosa;

1984
Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:4

    Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Female; Gastric Acid; Gastric Mucosa;

1984
Effects of exogenous administration of female sex hormones on gastric secretion and ulcer formation in the rat.
    European journal of pharmacology, 1984, Sep-03, Volume: 104, Issue:1-2

    Topics: Animals; Aspirin; Estrogens; Gastric Juice; Gonadal Steroid Hormones; Humans; Indomethacin; Male; Pr

1984
Water-immersion stress induces mucosal ischemia due to thromboxane A2-like substance and ulcer formation in rats.
    Japanese journal of pharmacology, 1984, Volume: 35, Issue:4

    Topics: Animals; Gastric Acid; Gastric Mucosa; Humans; Imidazoles; Immersion; Indomethacin; Ischemia; Male;

1984
MDL-646, a new synthetic E1-prostaglandin with local protective effects on the gastric mucosa.
    Prostaglandins, 1984, Volume: 28, Issue:2

    Topics: Alprostadil; Animals; Anti-Ulcer Agents; Blood Pressure; Ethanol; Gastric Juice; Gastric Mucosa; Hea

1984
Gastric cytoprotective properties of SCH 32651, a novel antiulcer agent.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 270, Issue:1

    Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cysteamine; Drug Evaluation, Preclinical; Duoden

1984
Protective action of almagate against bile-facilitated gastric ulceration in the pylorus-ligated (Shay) rat.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:10A

    Topics: Aluminum Hydroxide; Animals; Antacids; Bile; Carbonates; Female; Indomethacin; Magnesium; Magnesium

1984
Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC).
    Scandinavian journal of gastroenterology. Supplement, 1984, Volume: 92

    Topics: Adult; Anti-Inflammatory Agents; Aspirin; Carbazoles; Duodenal Ulcer; Gastric Mucosa; Humans; Indome

1984
Cytoprotective effect of SU-88, an anti-ulcer agent, in the rat.
    Japanese journal of pharmacology, 1984, Volume: 35, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Cell Survival; Chalcone; Chalcones; Cimetidine; Dinoprostone; Ethanol; G

1984
Cytoprotective and antisecretory effects of 11-deoxy-13,14-didehydro-16(s)-methyl PGE2 methylester (FCE 20700).
    Prostaglandins, leukotrienes, and medicine, 1984, Volume: 15, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Diarrhea; Dinoprostone; Ethanol; Gastric Juice; Indomethacin; Intestines

1984
Further evidences on gastric cytoprotection exerted by pirenzepine.
    Pharmacological research communications, 1984, Volume: 16, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin;

1984
Effects of sofalcone on necrotizing agents-induced gastric lesions and on endogenous prostaglandins in rats stomachs.
    Journal of pharmacobio-dynamics, 1984, Volume: 7, Issue:11

    Topics: Animals; Anti-Ulcer Agents; Chalcone; Chalcones; Dinoprostone; Gastric Mucosa; Indomethacin; Male; N

1984
Functional cytoprotection by certain antacids.
    Acta physiologica Hungarica, 1984, Volume: 64, Issue:3-4

    Topics: Animals; Antacids; Aspirin; Dinoprostone; Ethanol; Gastric Acidity Determination; Gastric Mucosa; In

1984
Pharmacological properties of the antiinflammatory agent 10-methylamine-11-H-indeno-[1,2-b]quinolin-11-one (MB432).
    Polish journal of pharmacology and pharmacy, 1983, Volume: 35, Issue:4

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Indomet

1983
Research on heterocyclic compounds. XV. Substitution influence on the pharmacological activity in a series of imidazo[1,2-a]pyridines.
    Il Farmaco; edizione scientifica, 1983, Volume: 38, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Imidazoles; Indomethacin; Lysosomes;

1983
Research on heterocyclic compounds. XVII. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acids.
    Il Farmaco; edizione scientifica, 1984, Volume: 39, Issue:5

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic A

1984
A method for induction of cold, indomethacin and restraint ulcers in rats.
    Methods and findings in experimental and clinical pharmacology, 1983, Volume: 5, Issue:5

    Topics: Animals; Antacids; Atropine; Cimetidine; Cold Temperature; Dose-Response Relationship, Drug; Indomet

1983
[Effect of 11-deoxyprostaglandin E1 on secretion of gastric juice].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1983, Volume: 69, Issue:8

    Topics: Alprostadil; Animals; Anti-Ulcer Agents; Ethanol; Gastric Acid; Gastric Juice; Indomethacin; Male; P

1983
Rapid induction of gastric ulceration in guinea pigs by sequential exposure to a barrier breaker and indomethacin.
    Pathology, 1983, Volume: 15, Issue:3

    Topics: Animals; Bile; Gastric Mucosa; Guinea Pigs; Indomethacin; Lysophosphatidylcholines; Stomach Ulcer; T

1983
Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative.
    Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dogs; Edema; Female; Guinea Pigs; Hemodynamics; Hind

1983
Different protective effects of dimercapto-butanediol stereoisomers in experimental gastric ulceration.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 265, Issue:1

    Topics: Animals; Dithioerythritol; Dithiothreitol; Female; Indomethacin; Rats; Rats, Inbred Strains; Stereoi

1983
[Hyperbaric oxygen therapy in indomethacin-induced gastric ulcer].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1983, Volume: 80, Issue:10

    Topics: Animals; Hyperbaric Oxygenation; Indomethacin; Male; Rats; Stomach Ulcer

1983
Effect of prostaglandin synthesis inhibitors on neurotensin and sodium salicylate-induced gastric cytoprotection in rats.
    Life sciences, 1983, Jun-20, Volume: 32, Issue:25

    Topics: Animals; Aspirin; Cold Temperature; Ethanol; Humans; Indomethacin; Male; Neurotensin; Prostaglandin

1983
Anti-ulcer activity and other pharmacological properties of lozilurea.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:12

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Dogs; Duodenal Ulcer; Female; Gastric Mucosa; Guinea Pigs; Hexo

1983
Effects of an antiulcer drug, sucralfate (a basic aluminum salt of sulfated disaccharide), on experimental gastric lesions and gastric secretion in rats.
    Digestive diseases and sciences, 1983, Volume: 28, Issue:11

    Topics: Acetates; Aluminum; Animals; Anti-Ulcer Agents; Aspirin; Gastric Mucosa; Histamine; Indomethacin; Ra

1983
FCE 20700, a cytoprotective PGE2 derivative, does not interfere with the antiinflammatory activity of indomethacin.
    International journal of tissue reactions, 1983, Volume: 5, Issue:4

    Topics: Animals; Dinoprostone; Drug Interactions; Gastric Mucosa; Indomethacin; Male; Prostaglandins E, Synt

1983
Indomethacin decreases resistance of gastric barrier to disruption by alcohol.
    Digestive diseases and sciences, 1984, Volume: 29, Issue:2

    Topics: Administration, Topical; Animals; Dogs; Ethanol; Female; Gastric Mucosa; Hydrogen-Ion Concentration;

1984
Role of lymphoid nodules in pathogenesis of indomethacin-induced gastric lesions in dogs.
    Digestive diseases and sciences, 1984, Volume: 29, Issue:4

    Topics: Administration, Oral; Animals; Dogs; Gastric Mucosa; Indomethacin; Lymphatic System; Male; Pyloric A

1984
Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats.
    Digestive diseases and sciences, 1984, Volume: 29, Issue:5

    Topics: Animals; Aspirin; Benzimidazoles; Chemical Phenomena; Chemistry; Duodenal Ulcer; Epirizole; Gastric

1984
Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats.
    European journal of pharmacology, 1984, Mar-02, Volume: 98, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Synergism; Female; Indomet

1984
Ulcerogenic effects of indomethacin in pregnant rats.
    Japanese journal of pharmacology, 1984, Volume: 34, Issue:2

    Topics: Animals; Female; Indomethacin; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Stomach Ulc

1984
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
    Toxicology and applied pharmacology, 1980, Mar-15, Volume: 52, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Biotransformation; Fenoprofen; Ibuprofen; Indometha

1980
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat.
    Gastroenterology, 1981, Volume: 80, Issue:1

    Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Indomethacin; Intestinal Diseases; Male;

1981
Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:4

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Diflunisal; Indomethaci

1981
Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics.
    Gastroenterology, 1983, Volume: 84, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Bacitracin; Ethanol; Female; Gastric Juice; Germ-Free Life; Indometh

1983
Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Carrageenan; Clonidine; Drug Therapy,

1983
Role of surface-active phospholipids in gastric cytoprotection.
    Science (New York, N.Y.), 1983, Mar-18, Volume: 219, Issue:4590

    Topics: Animals; Gastric Mucosa; Indomethacin; Phospholipids; Prostaglandins; Rats; Stomach Ulcer; Surface-A

1983
Gastric antisecretory and cytoprotective activities of SCH 28080.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dogs; Ethanol; Female; Gastric Acid; Gastric Mucosa

1983
[Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1983, Volume: 81, Issue:4

    Topics: Animals; Aspirin; Depression, Chemical; Duodenal Ulcer; Ethanol; Gastric Juice; Immersion; Indometha

1983
Exacerbation of acetic acid ulcer induced by non-steroidal anti-inflammatory drugs in rats.
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:2

    Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents; Aspirin; Gastric Emptying; Gastric Juice;

1983
Role of gastric acid and prostaglandins in the formation of gastric antral ulcers produced by indomethacin in the rat.
    Prostaglandins, 1981, Volume: 21 Suppl

    Topics: Animals; Cimetidine; Dinoprostone; Gastric Juice; Guanidines; Indomethacin; Prostaglandins E; Rats;

1981
Role of prostaglandin E2 on gastric ulcers induced by non-steroidal anti-inflammatory compounds (NOSAC).
    Gastroenterologia Japonica, 1981, Volume: 16, Issue:6

    Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Prostaglandins E; Rats; Rats, In

1981
[The role of endogenous prostaglandin in drug-induced gastrointestinal lesions--comparison of aspirin and indomethacin (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1981, Dec-01, Volume: 78, Issue:12

    Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Intestinal Diseases; Intestinal Mucosa

1981
[On the pharmacodynamics of acemetacin (author's transl)].
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:8A

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cats; Central Nervous Sy

1980
[Non-steroidal antirheumatics: side-effects and interactions].
    Schweizerische medizinische Wochenschrift, 1982, Aug-28, Volume: 112, Issue:35

    Topics: Anemia, Aplastic; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Drug Interactions; Gastrointes

1982
Indomethacin decreases arterial blood pressure and plasma renin activity in rats with aortic ligation.
    Circulation research, 1981, Volume: 49, Issue:1

    Topics: Animals; Aorta; Blood Pressure; Heart Rate; Hypertension; Indomethacin; Ligation; Male; Rats; Renin;

1981
Cytoprotection by sulglycotide: prevention of gastric necrosis in rat.
    Pharmacological research communications, 1981, Volume: 13, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Epoprostenol; Gastric Mucosa; Indomethacin; Male; Necrosi

1981
Effects of a novel acylindole derivative on experimental thrombotic models, ulceration of the gastric mucosa and prostacyclin production in the aorta.
    Thrombosis research, 1981, Nov-01, Volume: 24, Issue:3

    Topics: Animals; Aorta; Arteriovenous Shunt, Surgical; Blood Platelets; Epoprostenol; Fibrinolytic Agents; G

1981
Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins.
    Gut, 1982, Volume: 23, Issue:6

    Topics: Acetaminophen; Animals; Aspirin; Epoprostenol; Ethanol; Female; Gastric Mucosa; Indomethacin; Male;

1982
[Antiulcerogenic action of 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one (KB-509), a new benzodiazepine derivative].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1981, Volume: 77, Issue:3

    Topics: 11-Hydroxycorticosteroids; Animals; Anticonvulsants; Benzodiazepinones; Drug Evaluation, Preclinical

1981
The influence of paracetamol on the erosive activity of indomethacin in the rat stomach.
    Agents and actions, 1982, Volume: 12, Issue:1-2

    Topics: Acetaminophen; Administration, Oral; Animals; Aspirin; Indomethacin; Injections, Subcutaneous; Male;

1982
[Pyopneumopericarditis complicating a perforated hiatus hernia ulcer (author's transl)].
    Journal de radiologie, 1982, Volume: 63, Issue:3

    Topics: Aged; Female; Hernia, Diaphragmatic; Hernia, Hiatal; Humans; Indomethacin; Peptic Ulcer Perforation;

1982
Testing for drugs inhibiting the formation of gastric ulcers.
    Journal of pharmacological methods, 1982, Volume: 8, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cold Temperature; Copper; Indomethacin; Mucus; Orga

1982
Gastroprotective and anti-inflammatory properties of green lipped mussel (Perna canaliculus) preparation.
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bivalvia; Female; Freeze Drying; Indomethacin; Male; Rat

1980
Effects of CL-1700 and its constituents on acute or chronic gastric lesions and gastric secretion in rats.
    Japanese journal of pharmacology, 1982, Volume: 32, Issue:3

    Topics: Aluminum Hydroxide; Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dipeptides; Gastric Juice; Hista

1982
Does indomethacin activate healed gastric ulcers in the dog?
    Digestion, 1981, Volume: 21, Issue:4

    Topics: Animals; Dogs; Indomethacin; Male; Stomach Ulcer

1981
Indomethacin produces gastric antral ulcers in the refed rat.
    Gastroenterology, 1981, Volume: 81, Issue:4

    Topics: Adrenalectomy; Animals; Aspirin; Fasting; Indomethacin; Intestines; Male; Phenylbutazone; Prostaglan

1981
Interaction of indomethacin and aspirin or mepirizole in rats as shown by gastrointestinal ulcerogenic and anti-inflammatory activities.
    Journal of pharmacobio-dynamics, 1980, Volume: 3, Issue:12

    Topics: Animals; Aspirin; Biological Transport; Charcoal; Drug Interactions; Edema; Epirizole; Indomethacin;

1980
Synthesis and anti-ulcer activity of 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1.
    Prostaglandins, 1981, Volume: 22, Issue:2

    Topics: Alprostadil; Animals; Indomethacin; Magnetic Resonance Spectroscopy; Prostaglandins E, Synthetic; Ra

1981
[Inhibition of indomethacin-induced gastric ulceration in the rat by 7-oxo-prostaglandin E1 analogs (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1981, Volume: 101, Issue:3

    Topics: Alprostadil; Animals; Anti-Ulcer Agents; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Prost

1981
Gastric cytoprotection by sodium salicylate.
    Prostaglandins, 1981, Volume: 21 Suppl

    Topics: Animals; Aspirin; Ethanol; Gastric Mucosa; Indomethacin; Male; Rats; Salicylates; Salicylic Acid; St

1981
Study of antiulcer activity of aqueous extract of leaves of Pyrenacantha staudtii (family Icacinaceae) using various models of experimental gastric ulcer in rats.
    European journal of pharmacology, 1981, Sep-11, Volume: 74, Issue:2-3

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Female; Indomethacin; Male; Nigeria; Pl

1981
Aggravating effect of ergometrine on pyloric antral lesions in indomethacin-treated animals and stimulating effect of this drug on gastric acid secretion.
    Japanese journal of pharmacology, 1981, Volume: 31, Issue:6

    Topics: Animals; Ergonovine; Gastric Acid; Indomethacin; Male; Methysergide; Mice; Mice, Inbred Strains; Pyl

1981
Effects of N-acetyl-L-carnosine aluminum (CL-1700) on various acute gastric lesions and gastric secretion in rats.
    Japanese journal of pharmacology, 1981, Volume: 31, Issue:6

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dipeptides; Gastric Mucosa; Indomethacin; Male; Phen

1981
The effects of indomethacin of the rat gastric mucosa.
    Yonsei medical journal, 1981, Volume: 22, Issue:2

    Topics: Animals; Gastric Mucosa; Indomethacin; Rats; Rats, Inbred Strains; Stomach Ulcer; Time Factors

1981
Gastric perforation associated with indomethacin therapy in a pre-term infant.
    Australian paediatric journal, 1980, Volume: 16, Issue:1

    Topics: Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant,

1980
Gastrointestinal myoelectric activity disturbances in gastric ulcer disease in rats and dogs.
    Digestive diseases and sciences, 1980, Volume: 25, Issue:8

    Topics: Animals; Digestive System; Dogs; Duodenum; Electrophysiology; Female; Gastrointestinal Motility; Ind

1980
Indomethacin and perforated duodenal ulcer.
    British medical journal, 1980, Jul-19, Volume: 281, Issue:6234

    Topics: Duodenal Ulcer; Humans; Indomethacin; Peptic Ulcer Perforation; Stomach Ulcer

1980
Indomethacin and perforated duodenal ulcer.
    British medical journal, 1980, Jun-28, Volume: 280, Issue:6231

    Topics: Duodenal Ulcer; Female; Humans; Indomethacin; Middle Aged; Peptic Ulcer Perforation; Stomach Ulcer

1980
Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal.
    The Journal of pathology, 1980, Volume: 131, Issue:4

    Topics: Animals; Diflunisal; Drug Therapy, Combination; Granuloma; Indomethacin; Male; Rats; Salicylates; St

1980
[Cytoprotection. A new fashion or real progress?].
    Polskie Archiwum Medycyny Wewnetrznej, 1980, Volume: 64, Issue:2

    Topics: Animals; Aspirin; Gastric Mucosa; Gastritis; Humans; Indomethacin; Prostaglandins E, Synthetic; Rats

1980
[Reduced ulcerogenic effect after treatment with indomethacin combined with diflunisal in rats].
    Bollettino della Societa italiana di biologia sperimentale, 1980, Apr-30, Volume: 56, Issue:8

    Topics: Animals; Diflunisal; Drug Interactions; Gastric Mucosa; Indomethacin; Male; Potassium Permanganate;

1980
Different effects of indomethacin and nabumetone on prostaglandin-mediated gastric responses to central vagal activation in rats.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Gastric Juice; Indomethacin; Male; Nabu

1995
Sulpiride specifically attenuates psychological stress-induced gastric lesions in rodents.
    Japanese journal of pharmacology, 1995, Volume: 68, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Famotidine; Gastric Acid; Indomethacin; Male; Mice; Mice, Inbred ICR; Py

1995
Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:4

    Topics: Animals; Cyclosporine; Duodenal Ulcer; Immunosuppressive Agents; Indomethacin; Intestine, Small; Mal

1994
Omentum and basic fibroblast growth factor in healing of chronic gastric ulcerations in rats.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:5

    Topics: Animals; Blood Flow Velocity; Chronic Disease; Dinoprostone; Eflornithine; Fibroblast Growth Factor

1994
Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats.
    Pharmacological research, 1994, Volume: 29, Issue:3

    Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucins; Hydralazine; Indomethacin; M

1994
Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin.
    The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 1

    Topics: Animals; Bromodeoxyuridine; Drug Combinations; Female; Fibroblast Growth Factor 2; Gastric Acid; Gas

1995
The differential mechanisms of mild irritants on adaptive cytoprotection.
    Journal of gastroenterology and hepatology, 1994, Volume: 9 Suppl 1

    Topics: Adaptation, Physiological; Animals; Arginine; Atropine; Capsaicin; Chorionic Gonadotropin; Ethanol;

1994
Effects of free radical scavengers on indomethacin-induced aggravation of gastric ulcer in rats.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:9

    Topics: Acetates; Acetic Acid; Allopurinol; Animals; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Free Rad

1995
Ulcerogenicity and effect on inhibition of prostaglandin generation of indometacin farnesil, a prodrug of indomethacin, in rat gastric mucosa: comparison with indomethacin or loxoprofen.
    Drugs under experimental and clinical research, 1995, Volume: 21, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Epoprostenol; Gastric Mucosa; Indome

1995
Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions.
    Gastroenterology, 1995, Volume: 109, Issue:4

    Topics: Acetates; Acetic Acid; Animals; Base Sequence; Cell Line; Cells, Cultured; DNA; Fibroblast Growth Fa

1995
Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats.
    Gastroenterology, 1995, Volume: 109, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;

1995
Gastroprotective activity of the novel proton pump inhibitor lansoprazole in the rat.
    General pharmacology, 1995, Volume: 26, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Dru

1995
Anti-ulcer effect of the hot water extract of black tea (Camellia sinensis).
    Journal of ethnopharmacology, 1995, Volume: 46, Issue:3

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; India; Indomethacin; Plant Extracts; Pros

1995
Antiulcer activity of Pteleopsis suberosa.
    Journal of ethnopharmacology, 1995, Jun-23, Volume: 47, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Indomethacin; Male; Medicine, Tradition

1995
Effects of lansoprazole on ethanol-induced injury and PG synthetic activity in rat gastric mucosa.
    Journal of clinical gastroenterology, 1995, Volume: 20 Suppl 2

    Topics: 16,16-Dimethylprostaglandin E2; 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory

1995
Protection by almagate of ethanol-induced gastric mucosal damage in rats.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:2

    Topics: Administration, Oral; Aluminum Hydroxide; Animals; Antacids; Carbonates; Disease Models, Animal; Dos

1995
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Aci

1995
Cytoprotective and antisecretory activity of a ranitidine-zinc complex.
    Prostaglandins, leukotrienes, and essential fatty acids, 1995, Volume: 52, Issue:6

    Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Ethanol; Gastric Acid; Gastric Mucosa;

1995
Interaction of nitric oxide and salivary gland epidermal growth factor in the modulation of rat gastric mucosal integrity.
    British journal of pharmacology, 1993, Volume: 110, Issue:1

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Epidermal Growth Factor; Gastric Muco

1993
Effect of acetaminophen on stress-induced gastric mucosal lesions in rats.
    Research communications in molecular pathology and pharmacology, 1994, Volume: 86, Issue:3

    Topics: Acetaminophen; Animals; Dinoprostone; Drug Combinations; Gastric Mucosa; Glutathione; Indomethacin;

1994
The cytoprotective effect of the immunomodulator AS101 against hydrochloride induced gastric lesions.
    Research communications in molecular pathology and pharmacology, 1995, Volume: 87, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Dinoprostone; Dose-Response Relationship, Drug; Epidermal Growth Fa

1995
Neutrophil infiltration does not contribute to the ulcerogenic effects of indomethacin in the rat gastric antrum.
    Agents and actions, 1994, Volume: 43, Issue:1-2

    Topics: Animals; Female; Indomethacin; Neutrophils; Pyloric Antrum; Radioimmunoassay; Rats; Rats, Sprague-Da

1994
Inhibition of inflammation and gastric damage in rats by copper (II) complexes.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Behavior, Animal; Carrageenan;

1995
L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats.
    Neuropharmacology, 1994, Volume: 33, Issue:12

    Topics: Analgesics; Animals; Cyclooxygenase Inhibitors; Indans; Indomethacin; Male; Piroxicam; Rats; Rats, S

1994
Gastric blood flow in ulcer diseases.
    Scandinavian journal of gastroenterology. Supplement, 1995, Volume: 208

    Topics: Animals; Blood Flow Velocity; Carbachol; Dogs; Ethanol; Gastric Acid; Gastric Mucosa; Hemoglobins; H

1995
Gastroprotective effect of aqueous extract of Cistus incanus L. in rats.
    Pharmacological research, 1995, Volume: 31, Issue:1

    Topics: Animals; Ethanol; Flavonoids; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Male; Medicine, Tradi

1995
Effect of zinc on the anti-inflammatory and ulcerogenic activities of indometacin and diclofenac.
    Pharmacology, 1995, Volume: 50, Issue:4

    Topics: Analysis of Variance; Animals; Diclofenac; Drug Interactions; Indomethacin; Male; Rats; Stomach Ulce

1995
Effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion in pylorus-ligated rat.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; Gastric Acid; Gastric Mucos

1995
Effects of the acetylene compound from Atractylodes rhizome on experimental gastric ulcers induced by active oxygen species.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:10

    Topics: Acetylene; Administration, Oral; Alkynes; Animals; Anti-Ulcer Agents; Disease Models, Animal; Diynes

1994
Synthesis and pharmacological evaluation of oligoethylene ester derivatives as indomethacin oral prodrugs.
    Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromatography, High Pressure Liquid;

1994
Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury.
    Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Blood Flow Velocity; Dogs; Gastric Acid; Gastric Mucosa; Guanid

1994
Enhancement of gastric mucosal blood flow by beta-3 adrenergic agonists prevents indomethacin-induced antral ulcer in the rat.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:2

    Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Female; Gastric Mucosa; Guinea Pigs; Heart Rate;

1994
[The effect of dopamine and PGI2 on indomethacin and alcohol-induced gastric lesions in rats of various ages in relation to gastric vascular permeability and HCl secretion].
    Bratislavske lekarske listy, 1993, Volume: 94, Issue:11

    Topics: Aging; Animals; Capillary Permeability; Dopamine; Epoprostenol; Ethanol; Gastric Acid; Gastric Mucos

1993
Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins.
    General pharmacology, 1994, Volume: 25, Issue:3

    Topics: Animals; Edema; Ethanol; Gastric Mucosa; Gastrointestinal Hemorrhage; Indomethacin; Male; Prostaglan

1994
YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Benzodiazepines; Duodenal Ulcer; Epirizole; Ethanol; Famotidine; Gastric

1994
Leukotrienes do not contribute to the pathogenesis of indomethacin-induced ulceration of the gastric antrum in the re-fed rat.
    Agents and actions, 1994, Volume: 41, Issue:3-4

    Topics: Administration, Oral; Animals; Benzopyrans; Female; Indazoles; Indoles; Indomethacin; Injections, Su

1994
Synthesis and anti-inflammatory properties of 1,2-dialkoxy-4-(3-dimethylaminopropionyl)benzenes and their 5-halogeno derivatives.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Edema; Foot Inju

1994
Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:11

    Topics: Animals; Atropine; Deoxyglucose; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Ind

1994
A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats.
    Gut, 1994, Volume: 35, Issue:9

    Topics: Animals; Aspirin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Ethanol; Gastric Mucosa; Hy

1994
The differential roles of sympathetic nerve activity in the pathogenesis of antral and corpus lesions induced by indomethacin in rats.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2

    Topics: Animals; Blood Glucose; Catecholamines; Gastric Mucosa; Indomethacin; Insulin; Male; Oxidopamine; Pr

1994
Antiulcer effect of naringin on gastric lesions induced by ethanol in rats.
    Pharmacology, 1994, Volume: 49, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Dinoprostone; Ethanol; Flavanones; Flavonoids; Gastric Mu

1994
Influences of urethane anesthesia on indomethacin-induced gastric mucosal lesions in rats. Relation to blood glucose levels.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:12

    Topics: Anesthesia, General; Animals; Blood Glucose; Gastric Acid; Gastric Mucosa; Gastrointestinal Motility

1994
Mucus synthesis and sulfhydryl groups in cytoprotection mediated by dehydroleucodine, a sesquiterpene lactone.
    Journal of natural products, 1994, Volume: 57, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Indomethacin; Lactones; Male; Mucus; Plants, Me

1994
Biochemical evaluation of the antiulcerogenic effect of Cauvery-100 (an ayurvedic formulation) in rats.
    Journal of ethnopharmacology, 1994, Volume: 42, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Antidiarrheals; Gastric Juice; Hexosamines; Hexoses; Indomethacin; Male;

1994
Aminopyrazinyl derivatives: synthesis and evaluation of antiinflammatory and related activities.
    Farmaco (Societa chimica italiana : 1989), 1994, Volume: 49, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Edema; Femal

1994
Protection against necrotizing agents-induced gastric lesions in rats. Unrelated to inhibition of gastric motility.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:9

    Topics: Animals; Ethanol; Female; Gastrointestinal Motility; Hydrochloric Acid; Indomethacin; Male; Papaveri

1994
Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indometacin in rats.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:12

    Topics: Alanine; Animals; Anti-Ulcer Agents; Free Radicals; Gastric Mucosa; Indomethacin; Lipid Peroxidation

1993
Protective effect of Swertia chirata against indomethacin and other ulcerogenic agent-induced gastric ulcers.
    Drugs under experimental and clinical research, 1993, Volume: 19, Issue:2

    Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Male; Plant Extracts; Plants, Medicinal; Rats; Rats,

1993
Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:4

    Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Benzimidazoles; Duodenal Ulcer; Epirizole; Ethano

1993
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
    Canadian journal of physiology and pharmacology, 1993, Volume: 71, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response

1993
Green banana protection of gastric mucosa against experimentally induced injuries in rats. A multicomponent mechanism?
    Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:10

    Topics: Acute Disease; Animals; Chronic Disease; Ethanol; Fruit; Gastric Mucosa; Indomethacin; Male; Models,

1993
Potentiating interactions between medullary serotonin and thyrotropin-releasing hormone-induced gastric erosions in rats.
    Neuroscience letters, 1993, Oct-29, Volume: 161, Issue:2

    Topics: Animals; Cold Temperature; Indomethacin; Injections; Injections, Intravenous; Ketanserin; Male; Medu

1993
Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage.
    Agents and actions, 1993, Volume: 39 Spec No

    Topics: Administration, Oral; Animals; Arthritis; Aspirin; Female; Gastric Mucosa; Indoles; Indomethacin; In

1993
The rat gastric phospholipids: increased in ulcerated mucosa and decreased after healing.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1993, Volume: 25, Issue:6

    Topics: Animals; Chronic Disease; Fasting; Fatty Acids; Gastric Mucosa; Indomethacin; Male; Phospholipids; P

1993
Endotoxin protects the gastric mucosa against ulcerogenic stimuli.
    Biochemical and biophysical research communications, 1993, Dec-30, Volume: 197, Issue:3

    Topics: Animals; Endotoxins; Escherichia coli; Ethanol; Gastric Acid; Gastric Emptying; Gastric Mucosa; Indo

1993
Role of oxygen radicals in indomethacin-induced gastric mucosal microvascular injury in rats.
    Journal of clinical gastroenterology, 1993, Volume: 17 Suppl 1

    Topics: Animals; Capillary Permeability; Catalase; Endothelium, Vascular; Gastric Mucosa; Indomethacin; Lipi

1993
Multiple mediators and mechanisms are involved in the adaptive cytoprotection provided by certain mild irritants.
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:2

    Topics: Animals; Arginine; Gastric Mucosa; Indomethacin; Irritants; Male; Nitric Oxide; Nitroarginine; Prost

1993
A role for calcitonin gene-related peptide in protection against gastric ulceration.
    Annals of surgery, 1994, Volume: 219, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Gastric Mucosa; Indomethacin; Male; Neurons, Af

1994
Antiulcer and gastroprotective effects of quercetin: a gross and histologic study.
    Pharmacology, 1994, Volume: 48, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Ethanol; Gastric Mucosa; Hexosamines; Indomethacin; Male;

1994
Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Benzimid

1993
Effect and mechanism of sucralfate on healing of acetic acid-induced gastric ulcers in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1993, Volume: 44, Issue:2

    Topics: Acetates; Acetic Acid; Animals; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred

1993
Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate.
    Alimentary pharmacology & therapeutics, 1993, Volume: 7, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Bismuth; Citrates; Dogs; Ethanol; Female; Ferrets; Gastric Acid; Gastric

1993
Investigations of indomethacin-induced gastric ulcer in rats.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:7

    Topics: Animals; Dinoprostone; Eicosanoids; Epoprostenol; Gastric Mucosa; Indomethacin; Leukotriene Antagoni

1993
New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II.
    Farmaco (Societa chimica italiana : 1989), 1993, Volume: 48, Issue:6

    Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena

1993
Do infiltrating neutrophils contribute to the pathogenesis of indomethacin induced ulceration of the rat gastric antrum?
    Gut, 1993, Volume: 34, Issue:2

    Topics: Animals; Cell Movement; Indomethacin; Leukocyte Count; Leukotriene B4; Neutrophils; Pyloric Antrum;

1993
Pharmacological and pharmaceutical properties of freeze-dried formulations of egg albumin, indomethacin, olive oil, or fatty acids.
    Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:7

    Topics: Administration, Oral; Animals; Biological Availability; Carrageenan; Drug Carriers; Edema; Fatty Aci

1993
Synthesis and evaluation of morpholinoalkyl ester prodrugs of indomethacin and naproxen.
    Pharmaceutical research, 1993, Volume: 10, Issue:8

    Topics: Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pres

1993
Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats.
    Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:1

    Topics: Animals; Chronic Disease; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Phosp

1993
An animal model of longitudinal ulcers in the small intestine induced by intracolonically administered indomethacin in rats.
    Gastroenterologia Japonica, 1993, Volume: 28, Issue:1

    Topics: Animals; Cecal Diseases; Colon; Disease Models, Animal; Duodenal Ulcer; Indomethacin; Intestinal Muc

1993
Mechanism by which indomethacin delays gastric ulcer healing in the rat: inhibited contraction of the ulcer base.
    Japanese journal of pharmacology, 1993, Volume: 61, Issue:2

    Topics: Acetates; Acetic Acid; Animals; Connective Tissue; Gastric Mucosa; Indomethacin; Male; Muscle Contra

1993
Effects of indomethacin and prednisolone on the different stages of healing of acetic acid-induced gastric ulcers in the rat.
    Japanese journal of pharmacology, 1993, Volume: 61, Issue:2

    Topics: Acetates; Acetic Acid; Animals; Collagen; Connective Tissue; Gastric Mucosa; Indomethacin; Male; Pre

1993
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
    General pharmacology, 1993, Volume: 24, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena

1993
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
    Cell, 1995, Nov-03, Volume: 83, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blotting, Northern; Blotting, We

1995
NSAID-induced delay in gastric ulcer healing is not associated with decreased epithelial cell proliferation in rats.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Epithelial Cells; Epitheli

1995
Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antilymphocyte Serum; Etodolac; Gastric Mucosa; Ga

1995
Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines.
    Digestion, 1995, Volume: 56, Issue:6

    Topics: Animals; Arginine; Chronic Disease; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Efl

1995
Indomethacin interferes with epidermal growth factor binding and proliferative response of gastric KATO III cells.
    Digestion, 1995, Volume: 56, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cell Survival; Cells, Cultured; Epidermal Gr

1995
Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers.
    Gut, 1995, Volume: 37, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell

1995
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
    Chemical & pharmaceutical bulletin, 1995, Volume: 43, Issue:11

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole;

1995
Anti-ulcer activity of higher primary alcohols of beeswax.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:9

    Topics: Administration, Oral; Alcohols; Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Etha

1995
Effect of 10% ethanol and sofalcone on prostaglandin E2 content, mucus gel thickness, and experimental ulcers in the stomach of developing rats.
    Digestion, 1996, Volume: 57, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Anti-Ulcer Agents; Chalcone; Chalcones; Dinoprostone; Dose-Respons

1996
Effect of vitamin E and selenium on hypothermic restraint stress and chemically-induced ulcers.
    Digestive diseases and sciences, 1996, Volume: 41, Issue:6

    Topics: Animals; Antioxidants; Cold Temperature; Hydrochloric Acid; Immobilization; Indomethacin; Rats; Rats

1996
Anti-inflammatory and analgesic activity of Baccharis trimera: identification of its active constituents.
    Planta medica, 1996, Volume: 62, Issue:3

    Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanols; Carra

1996
Aggravating process induced by indomethacin on chronic gastric lesion in rat. Role of polymorphonuclear leucocytes.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Hydroxyurea; Indomethacin

1995
Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats.
    Journal of gastroenterology and hepatology, 1996, Volume: 11, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Benzimidazoles; Indomethacin; Male; Omeprazole; Peroxidase; Rats; Rats,

1996
Effects of the novel histamine H2-receptor antagonist (+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2-[[[5- (methylamino)methyl-2-furyl]methyl]thio]ethyl]-2-(methylsulfonyl) guanidine on gastric secretion and gastroduodenal ulcers in rats.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Epirizole; Gastric Acid; Gastric Mucos

1996
Mast cells do not contribute to nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rodents.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Dexa

1996
Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity.
    Digestive diseases and sciences, 1996, Volume: 41, Issue:8

    Topics: Age Factors; Animals; Animals, Newborn; Capsaicin; Ethanol; Gastric Mucosa; Indomethacin; Male; Neur

1996
Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence.
    The American journal of physiology, 1996, Volume: 270, Issue:1 Pt 1

    Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Gastroi

1996
The importance of gastric emptying and mucosal folds in the adaptive cytoprotection of mild irritants in rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:12

    Topics: Adaptation, Physiological; Animals; Anti-Ulcer Agents; Ethanol; Gastric Emptying; Gastric Mucosa; Hy

1995
The role of acid in the pathogenesis of indomethacin-induced gastric antral ulcers in the rat.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cimetidine; Female; Gastric Aci

1996
Influence of age on natural and delayed healing of experimentally-induced gastric ulcers in rats.
    Digestive diseases and sciences, 1996, Volume: 41, Issue:9

    Topics: Acetates; Acetic Acid; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male;

1996
Omeprazole prevents indomethacin-induced gastric ulcers in rabbits.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Enzyme Inhibitors; Gastric Acid; Gas

1996
A study of the antiulcer mechanisms of propranolol in rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:8

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Ulcer Agents; Blood Pressure; Ethanol; Gastric Mucosa; He

1996
Cytoprotective activity of cisapride on experimental gastric mucosal lesions induced by ethanol. Role of endogenous prostaglandins.
    Prostaglandins, 1996, Volume: 52, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Cisapride; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Mu

1996
Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins.
    Digestive diseases and sciences, 1996, Volume: 41, Issue:10

    Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Indomethacin; Male; Neu

1996
Pharmacokinetics of indomethacin ester prodrugs: gastrointestinal and hepatic toxicity and the hydrolytic capacity of various tissues in rats.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:9

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Li

1996
Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat.
    Journal of gastroenterology and hepatology, 1996, Volume: 11, Issue:10

    Topics: Animals; Aspirin; Benzofurans; Ethanol; Female; Gastritis; Indomethacin; Iodoacetamide; Leukotriene

1996
Protective effect of taurine on indomethacin-induced gastric mucosal injury.
    Advances in experimental medicine and biology, 1996, Volume: 403

    Topics: Adult; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion;

1996
Effect of fish oil on indometacin-induced gastric lesions in rats.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:11

    Topics: Animals; Anti-Ulcer Agents; Diet; Fish Oils; Gastric Mucosa; Indomethacin; Male; Mucus; Olive Oil; P

1995
Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat.
    Gut, 1996, Volume: 39, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillaries; Cell Movement; Fasting; Gastric Mucos

1996
[Effects of Cuban analog (SWR-104SA), a new histamine H2 receptor antagonist, on gastric acid secretion and experimental ulcer formation].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1996, Volume: 116, Issue:10

    Topics: Animals; Dioxolanes; Ethanol; Gastric Acid; Gastrointestinal Motility; Guinea Pigs; Histamine H2 Ant

1996
Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene.
    Planta medica, 1996, Volume: 62, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ethanol; Gastric Mucosa; Indomethacin; Male; Polyc

1996
Anti-inflammatory and antiulcer activity of Teucrium buxifolium.
    Journal of ethnopharmacology, 1997, Volume: 55, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Experimental; Carrag

1997
Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats.
    Journal of ethnopharmacology, 1997, Volume: 55, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism

1997
Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats.
    British journal of pharmacology, 1997, Volume: 120, Issue:4

    Topics: Amyloid; Animals; Dose-Response Relationship, Drug; Ethanol; Gastric Acidity Determination; Gastric

1997
Gastric motility and mucosal ulcerogenic responses induced by prokinetic drugs in rats under prostaglandin-deficient conditions.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:2

    Topics: Animals; Cisapride; Dose-Response Relationship, Drug; Gastric Acid; Gastric Emptying; Gastric Mucosa

1997
Gastric ECL-cell hyperplasia produces enhanced basal and stimulated gastric acid output but not gastric erosion formation in the rat.
    General pharmacology, 1997, Volume: 28, Issue:3

    Topics: Animals; Carbachol; Enterochromaffin Cells; Female; Gastric Acid; Gastric Mucosa; Histamine; Hyperpl

1997
Investigations on the protective action of Condonopsis pilosula (Dangshen) extract on experimentally-induced gastric ulcer in rats.
    General pharmacology, 1997, Volume: 28, Issue:3

    Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Drugs, Chinese Herbal; Duodenum; Gastric Acid; Gastric Muco

1997
Increased expression of transforming growth factor-beta1 during gastric ulcer healing in rats.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:3

    Topics: Acetic Acid; Alprostadil; Animals; Blotting, Northern; Extracellular Matrix Proteins; Gastric Mucosa

1997
Bosentan, a novel synthetic mixed-type endothelin receptor antagonist, attenuates acute gastric mucosal lesions induced by indomethacin and HCl in the rat: role of endogenous endothelin-1.
    Journal of gastroenterology, 1997, Volume: 32, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bosentan; Endothelin Receptor Antagonists; Endothe

1997
Gastroprotective effect of malotilate in indomethacin- and ethanol-induced gastric mucosal damage.
    Physiological research, 1996, Volume: 45, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Indome

1996
Cell kinetic events in early indomethacin-induced gastrointestinal ulcerations in the rat.
    European journal of gastroenterology & hepatology, 1997, Volume: 9, Issue:3

    Topics: Animals; Biopsy; Cell Division; Dinoprostone; Dose-Response Relationship, Drug; Gastric Fundus; Gast

1997
Gastric mucosal injury by nonsteroidal anti-inflammatory drugs is reduced by (R)-alpha-methylhistamine and its pro-drugs in the rat.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Acid; Gastric Mucosa; Histamine A

1997
Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor.
    Japanese journal of pharmacology, 1997, Volume: 73, Issue:3

    Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen

1997
Effect of quinacrine, a phospholipase A2 inhibitor on stress and chemically induced gastroduodenal ulcers.
    Digestion, 1997, Volume: 58, Issue:2

    Topics: Animals; Cyclooxygenase Inhibitors; Cysteamine; Duodenal Ulcer; Enzyme Inhibitors; Ethanol; Female;

1997
Flavonoid-induced gastroprotection in rats: role of blood flow and leukocyte adherence.
    Digestion, 1997, Volume: 58, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Disease Models, Animal; Flavonoids;

1997
Comparative evaluation of the severity of gastric ulceration by solid dispersions and coprecipitates of indomethacin.
    Journal of drug targeting, 1997, Volume: 4, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Precipitation; Indomethacin; Male; Rats;

1997
Synthesis of amides with anti-inflammatory and analgesic activities.
    Farmaco (Societa chimica italiana : 1989), 1997, Volume: 52, Issue:2

    Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Gas Chromatogr

1997
Analysis of pathogenic elements involved in gastric lesions induced by non-steroidal anti-inflammatory drugs in rats.
    Journal of gastroenterology and hepatology, 1997, Volume: 12, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Deoxyglucose; Disease Models, Ani

1997
Intracisternal injection of basic fibroblast growth factor reduces the severity of gastric mucosal lesions evoked by ethanol in rats.
    The Japanese journal of physiology, 1997, Volume: 47, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Brain; Cisterna Magna; Disease Models, Animal; Ethanol; Fibroblast Growt

1997
The indomethacin-induced gastric mucosal damage in rats. Effect of gastric acid, acid inhibition, capsaicin-type agents and prostacyclin.
    Journal of physiology, Paris, 1997, Volume: 91, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diterpenes; E

1997
Protective effect of zinc gluconate on chemically induced gastric ulcer.
    The Indian journal of medical research, 1997, Volume: 106

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Biological Transport; Eth

1997
Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers.
    Human & experimental toxicology, 1997, Volume: 16, Issue:7

    Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomar

1997
[A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1997, Volume: 110, Issue:1

    Topics: Acetates; Animals; Anti-Ulcer Agents; Disease Models, Animal; Indomethacin; Infusion Pumps, Implanta

1997
Changes in sulfated macromolecules produced in vivo during normal and indomethacin-delayed ulcer healing in rats.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:8

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Glycosaminoglycans; G

1997
Study of the antisecretory and antiulcer mechanisms of a new indenopirydazinone derivative in rats.
    Pharmacological research, 1997, Volume: 35, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bethanechol; Female; Gastric Ac

1997
[Comparison of anti-ulcer properties of OF-900, OF-743 and their combination in various models of stomach ulcer induction in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1997, Volume: 124, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Drug Therapy, Combination; Ethanol; Indomethacin; Male; Rats; Stomach Ul

1997
Kinetics of fibroblasts in ulcer healing in rats: interference with indomethacin.
    Digestion, 1997, Volume: 58, Issue:4

    Topics: Acetic Acid; Actins; Animals; Apoptosis; Culture Techniques; Cyclooxygenase Inhibitors; Disease Mode

1997
Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine.
    Research communications in molecular pathology and pharmacology, 1997, Volume: 97, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Caustics; Disease Models, Anima

1997
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
    British journal of pharmacology, 1997, Volume: 122, Issue:3

    Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas

1997
Circadian reactivity rhythm of rat gastric mucosa to restraint-cold stress and indomethacin: temporal variation in the protective effect of iloprost.
    Chronobiology international, 1997, Volume: 14, Issue:6

    Topics: Animals; Anti-Ulcer Agents; Circadian Rhythm; Cold Temperature; Disease Models, Animal; Drug Adminis

1997
Increase in pH and prevention of gastropathy induced by nonsteroidal anti-inflammatory drugs.
    Scandinavian journal of gastroenterology, 1997, Volume: 32, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Hydrogen-Ion Concentration; Ind

1997
Effect of cold-stress and indomethacin on the biosynthesis of gastric sulfated mucin in rats.
    Research communications in molecular pathology and pharmacology, 1997, Volume: 98, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Cold Temperature; Ethanol; Gastric Mucin

1997
Platelet-derived growth factor reverses the effects induced by NSAIDs on ulcer healing.
    European journal of gastroenterology & hepatology, 1997, Volume: 9, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Gastric Mucosa; Granulatio

1997
ICAM-1 and P-selectin expression in a model of NSAID-induced gastropathy.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Indomethacin; Intercellular Adhesi

1998
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
    Japanese journal of pharmacology, 1998, Volume: 76, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;

1998
Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera--involvement of 5-lipoxygenase pathway.
    Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Arachidonate 5-Lipoxygenase; Aspirin; Ethanol; Female; Gastric Mucosa; G

1998
Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara.
    Planta medica, 1998, Volume: 64, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Cell Line; Cell Survival; Cimetidine; Diterpenes; Diterpenes, Clerodane;

1998
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
    British journal of pharmacology, 1998, Volume: 123, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dicl

1998
Nonsteroidal anti-inflammatory drugs may delay the repair of gastric mucosa by suppressing prostaglandin-mediated increase of hepatocyte growth factor production.
    Biochemical and biophysical research communications, 1998, Apr-17, Volume: 245, Issue:2

    Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Cholera Toxin; Cyclic AMP; Cyclooxygenase 1; C

1998
Mechanism by which indomethacin delays the healing of acetic acid-induced ulcers in rats. Role of neutrophil antichemotactic and chemotactic activities.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1998, Volume: 49, Issue:1

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotactic Factors; Dinoprostone; Ga

1998
SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1998, Volume: 49, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Ethylmaleimide; Female; Fl

1998
Effects of keratinocyte growth factor (KGF) on gut growth and repair.
    The Journal of pathology, 1998, Volume: 184, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Digestive System; Dose-Response Rel

1998
Gastric cytoprotective activity of dehydroleucodine in rats. Role of nitric oxide.
    Pharmacological research, 1998, Volume: 37, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Arginine; Central Nervous System Depressants; Cyclooxygenase Inhibitors;

1998
Biochemical and pharmacological characteristics of 3-butyryl-8-methoxy-4-[(2-thiophenyl)amino]quinoline, a new proton-pump inhibitor, in rabbit gastric microsomes and in rats.
    The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Acid; Gastric

1998
Prostaglandin, tumor necrosis factor alpha and neutrophils: causative relationship in indomethacin-induced stomach injuries.
    European journal of pharmacology, 1998, May-08, Volume: 348, Issue:2-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Resp

1998
Synthesis of some novel pyrazole derivatives as potential antiinflammatory agents with minimum ulcerogenic activity.
    Die Pharmazie, 1998, Volume: 53, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Foot; Gastric Mucosa; Indometh

1998
Involvement of ornithine decarboxylase and polyamines in epidermal growth factor-induced recovery of gastric mucosa from gastric lesions provoked by stress.
    Regulatory peptides, 1998, Jun-30, Volume: 74, Issue:2-3

    Topics: Animals; Anti-Ulcer Agents; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Gastric Mucosa

1998
Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats.
    Journal of ethnopharmacology, 1998, Volume: 62, Issue:1

    Topics: Animals; Balsams; Disease Models, Animal; Ethanol; Fabaceae; Gastric Acid; Gastric Mucosa; Indometha

1998
Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3

    Topics: Animals; Cyclooxygenase 2; Dinoprostone; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandi

1998
Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats.
    Digestive diseases and sciences, 1998, Volume: 43, Issue:9 Suppl

    Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Calcium; Gastric Mucos

1998
Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach.
    Digestive diseases and sciences, 1998, Volume: 43, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo

1998
Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:1

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; C

1998
Investigation on the mechanisms involved in the central protective effect of amylin on gastric ulcers in rats.
    British journal of pharmacology, 1998, Volume: 125, Issue:1

    Topics: Amyloid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Calcitonin; Enzyme Inh

1998
[Effect of T-593 on gastric bleeding and lesions induced by indomethacin and water-immersion stress in rats: improving effect of T-593 on reduced gastric mucosal blood flow in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Gastric Mucosa; Guanidines; Histamine H2 Antag

1998
Protective effects of oleanolic acid oligoglycosides on ethanol- or indomethacin-induced gastric mucosal lesions in rats.
    Life sciences, 1998, Volume: 63, Issue:17

    Topics: Animals; Ethanol; Gastric Acid; Gastric Mucosa; Glycosides; Indomethacin; Male; Oleanolic Acid; Phyt

1998
Protective role of melatonin and the pineal gland in modulating water immersion restraint stress ulcer in rats.
    Journal of clinical gastroenterology, 1998, Volume: 27 Suppl 1

    Topics: Animals; Cyclooxygenase Inhibitors; Free Radical Scavengers; Indomethacin; Male; Melatonin; Pineal G

1998
Effect of roxatidine bismuth citrate (MX1) against acetylsalicylic acid- and indomethacin-induced gastric mucosal damage in rats.
    Methods and findings in experimental and clinical pharmacology, 1998, Volume: 20, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Drug Combinations; Dru

1998
Immunosuppressive cells in bone marrow of patients with stomach cancer.
    Advances in experimental medicine and biology, 1998, Volume: 451

    Topics: Adenocarcinoma; Antibodies, Monoclonal; Bone Marrow; Bone Marrow Cells; Cell Adhesion; Cytotoxicity,

1998
Protection by Rhinax in various models of ulceration in rats.
    Journal of ethnopharmacology, 1998, Volume: 63, Issue:3

    Topics: Animals; Gastric Acid; Gastric Mucins; Hydrochloric Acid; Indomethacin; Ligation; Male; Medicine, Ay

1998
Relationship between vascular endothelial growth factor and angiogenesis in spontaneous and indomethacin-delayed healing of acetic acid-induced gastric ulcers in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1998, Volume: 49, Issue:4

    Topics: Acetic Acid; Animals; Cyclooxygenase Inhibitors; Endothelial Growth Factors; Gastric Mucosa; Indomet

1998
Anti-inflammatory and ulcerogenic effects of 3-(N,N-diethylamino) propylindometacin HCl.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Indomethacin; Male; Prodrugs; Rats; Rats, S

1997
[Role of interleukin-8 in indomethacin-induced stomach ulcer in rats].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 1997, Volume: 13, Issue:2

    Topics: Animals; Indomethacin; Interleukin-8; Male; Rats; Rats, Sprague-Dawley; Stomach Ulcer

1997
Role of antioxidants in gastric mucosal damage induced by indomethacin in rats.
    Methods and findings in experimental and clinical pharmacology, 1998, Volume: 20, Issue:10

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Capillary Perm

1998
Protective effect of melatonin on indomethacin-induced gastric injury in rats.
    Journal of pineal research, 1999, Volume: 26, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Free Radical Scavengers; Gastric Mucosa; G

1999
Characterization of antisecretory and antiulcer activity of CR 2945, a new potent and selective gastrin/CCK(B) receptor antagonist.
    European journal of pharmacology, 1999, Mar-12, Volume: 369, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anti-Ulcer Agents; Benzodiazepines; Benzodiazepinones; Calcium; Cats;

1999
Naloxone is protective against indomethacin-induced gastric damage in cholestatic rats.
    Journal of gastroenterology, 1999, Volume: 34, Issue:2

    Topics: Animals; Cholestasis; Dose-Response Relationship, Drug; Gastric Mucosa; Indomethacin; Male; Naloxone

1999
Anti-ulcerogenic properties of endothelin receptor antagonists in the rat.
    Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Endothelin Receptor Antagonists; Indomethacin; M

1999
Role of nitric oxide in indomethacin-induced gastric mucosal dysfunction in the rat.
    Experimental physiology, 1999, Volume: 84, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chelating Agents; Edetic Acid; Enzyme Inhibitors;

1999
Cytokine-induced neutrophil chemoattractants in healing of gastric ulcers in rats: expression of >40-kDa chemoattractant in delayed ulcer healing by indomethacin.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:5

    Topics: Animals; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Chemotaxis, Leukocyte; Growth Substa

1999
Antithrombin prevents stress-induced gastric mucosal injury by increasing the gastric prostacyclin level in rats.
    The Journal of laboratory and clinical medicine, 1999, Volume: 133, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Albumins; Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory

1999
Dual effect of female sex steroids on drug-induced gastroduodenal ulcers in the rat.
    Life sciences, 1999, Volume: 64, Issue:25

    Topics: Animals; Capillary Permeability; Cysteamine; Duodenal Ulcer; Estradiol; Female; Gastric Mucosa; Indo

1999
Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide.
    Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:6

    Topics: Animals; Arthritis, Experimental; Body Weight; Dinoprostone; Ethanol; Gastric Acid; Indomethacin; Ma

1999
Gastroprotective mechanism of lafutidine, a novel anti-ulcer drug with histamine H2-receptor antagonistic activity.
    Arzneimittel-Forschung, 1999, Volume: 49, Issue:6

    Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroida

1999
A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1999, Volume: 50, Issue:2

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inh

1999
Endothelin-1, interleukin-4 and nitric oxide synthase modulators of gastric mucosal injury by indomethacin: effect of antiulcer agents.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1999, Volume: 50, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Benzenesulfonates; E

1999
Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats.
    Japanese journal of pharmacology, 1999, Volume: 80, Issue:3

    Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Administration, Oral; Animals; Anti-Ulcer Agents; Capsai

1999
1',1'-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: a novel, orally effective cannabinoid with analgesic and anti-inflammatory properties.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:1

    Topics: Administration, Oral; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Ag

1999
Antiulcer effect of the N- and O-beta-D-glucopyranosides of 5-aminosalicylic acid.
    Archiv der Pharmazie, 1999, Volume: 332, Issue:9

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Glucoside

1999
Some studies on the rodenticidal action of indomethacin.
    Drug and chemical toxicology, 1999, Volume: 22, Issue:4

    Topics: Administration, Oral; Animals; Bile Ducts; Body Weight; Cholestyramine Resin; Diazepam; Drug Interac

1999
Human apolipoprotein A-IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice.
    FEBS letters, 1999, Oct-22, Volume: 460, Issue:1

    Topics: Age Factors; Animals; Apolipoproteins A; Gastric Acid; Gastric Mucosa; Gastrins; Humans; Indomethaci

1999
Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats.
    Inflammatory bowel diseases, 1999, Volume: 5, Issue:4

    Topics: Acetates; Administration, Oral; Animals; Colitis; Deferiprone; Disease Models, Animal; Gastric Mucos

1999
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
    European journal of pharmacology, 1999, Nov-26, Volume: 385, Issue:1

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;

1999
Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip.
    Journal of ethnopharmacology, 1999, Nov-30, Volume: 67, Issue:3

    Topics: Animals; Asteraceae; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Plant Extracts; Plants, Me

1999
Gastric mucosal cellular changes induced by indomethacin (NSAID) in male albino rats.
    Indian journal of experimental biology, 1999, Volume: 37, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Indomethacin; Male; Peptic Ulcer H

1999
Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats.
    European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Gas

2000
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
    Advances in experimental medicine and biology, 1999, Volume: 469

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi

1999
Difference between the effect of acute and chronic surgical vagotomy on the cytoprotective action of atropine against indomethacin-induced mucosal lesions on the gastrointestinal tract in rats.
    Journal of physiology, Paris, 1999, Volume: 93, Issue:6

    Topics: Animals; Atropine; Capillary Permeability; Dose-Response Relationship, Drug; Female; Gastric Mucosa;

1999
Preparation and pharmacodynamic evaluation of liposomes of indomethacin.
    Drug development and industrial pharmacy, 2000, Volume: 26, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Drug Carriers; Edema;

2000
Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine.
    European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Disease Models, Animal; Gastric Juice; Histamine H2 A

2000
Endothelial changes precede mucosal ulceration induced by indomethacin: an experimental study in the rat.
    Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endothelium, Vascular; Female; Indomethacin; Micro

2000
The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer.
    Journal of ethnopharmacology, 2000, Volume: 70, Issue:2

    Topics: Animals; Antioxidants; Cytoprotection; Euphorbiaceae; Female; Free Radical Scavengers; Fruit; Hexosa

2000
The roles of nitric oxide and prostaglandins in alterations of ulcerogenic and healing responses in adjuvant-induced arthritic rat stomachs.
    Alimentary pharmacology & therapeutics, 2000, Volume: 14 Suppl 1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Central Nervous System De

2000
The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model.
    Alimentary pharmacology & therapeutics, 2000, Volume: 14 Suppl 1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; Chalcone; Chalco

2000
Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids.
    Life sciences, 2000, Volume: 66, Issue:23

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Aspirin; Dothiep

2000
Matrix metalloproteinases 2 and 9 in indomethacin-induced rat gastric ulcer.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2000, Volume: 32, Issue:3

    Topics: Animals; Blotting, Northern; In Situ Hybridization; Indomethacin; Male; Matrix Metalloproteinase 2;

2000
Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind.
    Journal of agricultural and food chemistry, 2000, Volume: 48, Issue:6

    Topics: Animals; Anti-Ulcer Agents; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Fruit; In

2000
Cytoprotective effect of rabeprazole against ethanol-induced gastric mucosal damage: possible involvement of nitric oxide.
    Drugs under experimental and clinical research, 2000, Volume: 26, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce

2000
Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats.
    Journal of ethnopharmacology, 2000, Volume: 71, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Central Nervous System Depressa

2000
Antiulcerogenic effects of Tylophora conspicua in male rats.
    Phytotherapy research : PTR, 2000, Volume: 14, Issue:5

    Topics: Alkaloids; Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gas

2000
Interaction between NSAIDs and steroid in rat stomach: safety of nimesulide as a preferential COX-2 inhibitor in the stomach.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cycloo

2000
[Celecoxib vs indomethacin and acute gastric lesions in rats].
    Medicina, 2000, Volume: 60, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Digestive Sy

2000
Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats.
    Journal of ethnopharmacology, 2000, Volume: 72, Issue:3

    Topics: Anti-Ulcer Agents; Antidiarrheals; Gastrointestinal Motility; Indomethacin; Liliaceae; Methanol; Pla

2000
Evaluation of the antiulcerogenic activity of friedelan-3beta-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae).
    Journal of ethnopharmacology, 2000, Volume: 72, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Drug Evaluation; Gas Chromatography-Mass Spectrometry; Indomethacin; Mag

2000
Antiulcer effectiveness of Maytenus aquifolium spray dried extract.
    Phytotherapy research : PTR, 2000, Volume: 14, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Indomethacin; Male; Phytotherapy; Plant

2000
The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat.
    Peptides, 2000, Volume: 21, Issue:10

    Topics: Adrenergic alpha-Antagonists; Amyloid; Animals; Anti-Ulcer Agents; Calcitonin Gene-Related Peptide;

2000
Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats.
    Journal of ethnopharmacology, 2000, Volume: 73, Issue:3

    Topics: Animals; Asteraceae; Cyclohexanes; Disease Models, Animal; Indomethacin; Male; Methanol; Methylene C

2000
Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats.
    Inflammation, 2000, Volume: 24, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 2; Cycloox

2000
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.
    European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship,

2001
Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves.
    Gastroenterology, 2001, Volume: 120, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Adaptation, Physiological; Anesthesia; Animals; Anti-Inflammatory Agen

2001
Role of mucus reduction and luminal acid elevation in increased susceptibility of stomach to nonsteroidal antiinflammatory drug-induced injury in arthritic rats.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Dinoprostone; Do

2000
Nitric oxide donating compounds inhibit HCl-induced gastric mucosal lesions mainly via prostaglandin.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:2

    Topics: 16,16-Dimethylprostaglandin E2; Administration, Oral; Animals; Gastric Mucosa; Hydrochloric Acid; In

2001
The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetina

2001
Effect of methanolic extract of Cassia nigricans leaves on rat gastrointestinal tract.
    Fitoterapia, 2001, Volume: 72, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Ethanol; Gastroi

2001
Diazoxide, a K(ATP) opener, accelerates restitution of ethanol or indomethacin-induced gastric ulceration in rats independent of polyamines.
    Journal of gastroenterology and hepatology, 2001, Volume: 16, Issue:3

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diazoxide; Ethanol; Glyburide; Indo

2001
Delayed healing of gastric ulcers in adjuvant arthritis rats: role of acid secretion and basic fibroblast growth factor.
    Digestion, 2001, Volume: 63, Issue:3

    Topics: Animals; Arthritis, Rheumatoid; Blotting, Western; Disease Models, Animal; Fibroblast Growth Factors

2001
Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3

    Topics: Adaptation, Physiological; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; C

2001
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
    Microscopy research and technique, 2001, Jun-01, Volume: 53, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cycloo

2001
Rat as model for studying behavior effects of hCG.
    Seminars in reproductive medicine, 2001, Volume: 19, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Chorionic Gonadotropin; Electroencephalography; Electromyography

2001
Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion.
    Pharmacological research, 2001, Volume: 43, Issue:5

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrier Pro

2001
Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.
    Fitoterapia, 2001, Volume: 72, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Disease Models, An

2001
Medicinal flowers. III. Marigold. (1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis.
    Chemical & pharmaceutical bulletin, 2001, Volume: 49, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Blood Glucose; Calendula; Carbohydrate Sequence; Chemical Phenomena; Che

2001
Effect of centrally administered prolactin on gastric and duodenal ulcers in rats.
    Fundamental & clinical pharmacology, 2001, Volume: 15, Issue:3

    Topics: Acetic Acid; Animals; Chronic Disease; Cysteamine; Duodenal Ulcer; Ethanol; Gastric Acid; Gastric Ac

2001
Antiulcerogenic and analgesic effects of Maytenus aquifolium, Sorocea bomplandii and Zolernia ilicifolia.
    Journal of ethnopharmacology, 2001, Volume: 77, Issue:1

    Topics: Administration, Oral; Analgesics; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Gastric Mucosa; In

2001
The antiulcerative effect of Thai Musa species in rats.
    Phytotherapy research : PTR, 2001, Volume: 15, Issue:5

    Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Female; Indomethacin; Pla

2001
Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:8

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Gastri

2001
Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2001, Volume: 52, Issue:3

    Topics: Animals; Heat-Shock Proteins; HSC70 Heat-Shock Proteins; HSP47 Heat-Shock Proteins; HSP70 Heat-Shock

2001
Effects of diacerein on indomethacin-induced gastric ulceration.
    Pharmacology, 2001, Volume: 63, Issue:4

    Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dinoprostone; D

2001
Effect of hyperprolactinaemia as induced by pituitary homografts under kidney capsule on gastric and duodenal ulcers in rats.
    The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:11

    Topics: Acetic Acid; Acute Disease; Animals; Chronic Disease; Cysteamine; Duodenal Ulcer; Gastric Acid; Hype

2001
Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats.
    Alimentary pharmacology & therapeutics, 2001, Volume: 15, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cell Division; Cyclooxygenas

2001
Antiulcerogenic effect of Hippophae rhamnoides L.
    Phytotherapy research : PTR, 2001, Volume: 15, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Famotidine; Fruit; Indomethacin; Male; Misoprost

2001
Antiulcerogenic activity of crude ethanol extract and some fractions obtained from aerial parts of Artemisia annua L.
    Phytotherapy research : PTR, 2001, Volume: 15, Issue:8

    Topics: Animals; Anti-Ulcer Agents; Artemisia; Ethanol; Ethylmaleimide; Gas Chromatography-Mass Spectrometry

2001
Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs.
    Life sciences, 2001, Nov-21, Volume: 70, Issue:1

    Topics: Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Chronic Disease; Cysteamine; Disease Models,

2001
TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury.
    The Journal of clinical investigation, 2002, Volume: 109, Issue:2

    Topics: Alleles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cloning, Molecular; Gastri

2002
The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2001, Volume: 53, Issue:5

    Topics: Animals; Epoprostenol; Female; Gastric Mucosa; Honey; Indomethacin; Mannitol; Osmolar Concentration;

2001
The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats.
    Pharmacological research, 2002, Volume: 45, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship,

2002
Effects of Opuntia ficus-indica var. Saboten stem on gastric damages in rats.
    Archives of pharmacal research, 2002, Volume: 25, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ethanol; Ficus; Gastric Juice; Gastric Mu

2002
A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat.
    Clinical and experimental pharmacology & physiology, 2002, Volume: 29, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Central N

2002
Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase

2002
Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice.
    Journal of gastroenterology, 2002, Volume: 37, Issue:3

    Topics: Animals; Central Nervous System Depressants; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In

2002
Gastric ulcerogenic responses following barrier disruption in knockout mice lacking prostaglandin EP1 receptors.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16 Suppl 2

    Topics: Animals; Bridged Bicyclo Compounds; Caproates; Cytoprotection; Dinoprostone; Disease Models, Animal;

2002
Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16 Suppl 2

    Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygen

2002
Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils.
    Digestive diseases and sciences, 2002, Volume: 47, Issue:4

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inh

2002
Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;

2002
Antiulcerogenic activity of some sesquiterpene lactones isolated from Artemisia annua.
    Planta medica, 2002, Volume: 68, Issue:6

    Topics: Animals; Anti-Ulcer Agents; Artemisinins; Asteraceae; Carbenoxolone; Cimetidine; Drug Interactions;

2002
Antagonism of the gastrointestinal ulcerogenic effect of some nonsteroidal anti-inflammatory agents by sodium salicylate.
    The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relationship, Dru

1976
Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers.
    The American journal of digestive diseases, 1977, Volume: 22, Issue:8

    Topics: Administration, Oral; Animals; Aspirin; Carbachol; Depression, Chemical; Disease Models, Animal; Duo

1977
Inhibitors of gastric lesions in the rat.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:4

    Topics: Animals; Aspirin; Disease Models, Animal; Female; Glutamine; Histamine Antagonists; Indomethacin; Li

1978
Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats.
    Biochemistry and experimental biology, 1978, Volume: 14, Issue:2

    Topics: Animals; Disease Models, Animal; Female; Gastric Juice; Hydrogen-Ion Concentration; Indomethacin; Ma

1978
A comparative study of the effects of prostaglandins and H2-receptor antagonists on gastric acid secretion, mucosal blood flow and ulcer formation.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:4

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Constipation; Dogs; Female; Gastric Mucosa; Gastrointestina

1979
Gastric mucosal injury from common drugs.
    Postgraduate medicine, 1978, Volume: 63, Issue:4

    Topics: Adrenal Cortex Hormones; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; G

1978
A new anti-inflammatory derivative of imidazole which is less ulcerogenic than indomethacin in rats.
    Acta pharmacologica et toxicologica, 1979, Volume: 45, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Biological Availability; Chemical Phenomena; Chemistry; Drug Eval

1979
The action of salmon calcitonin on indomethacin-induced gastric ulceration in the mouse [proceedings].
    British journal of pharmacology, 1979, Volume: 66, Issue:1

    Topics: Animals; Calcitonin; Indomethacin; Mice; Salmon; Stomach Ulcer

1979
Influence of fasting and cimetidine on the relationship between ulcerogenic and anti-inflammatory properties of indomethacin.
    British journal of pharmacology, 1979, Volume: 67, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cimetidine; Drug Interactions; Fasting; Fatty Acids,

1979
Correlation between the rise in acute phase proteins and histological evidence of ulceration in the rat following indomethacin treatment [proceedings].
    British journal of pharmacology, 1979, Volume: 67, Issue:3

    Topics: Animals; Glycoproteins; Indomethacin; Male; Rats; Stomach Ulcer

1979
The action of salmon calcitonin on indomethacin-induced gastric ulceration in the rat [proceedings].
    British journal of pharmacology, 1979, Volume: 67, Issue:3

    Topics: Animals; Calcitonin; Indomethacin; Rats; Salmon; Stomach Ulcer

1979
Interaction of salicylates and other non-steroidal anti-inflammatory agents in rats as shown by gastro-ulcerogenic and anti-inflammatory activities, and plasma concentrations.
    Acta pharmacologica et toxicologica, 1979, Volume: 45, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Drug Interactions; Gastric Mucosa; Indometh

1979
Effect of indomethacin on blood flow distribution in the stomach of cats with acute gastric ulcer.
    Scandinavian journal of gastroenterology, 1979, Volume: 14, Issue:8

    Topics: Acute Disease; Animals; Blood Pressure; Cardiac Output; Female; Gastric Mucosa; Heart Rate; Indometh

1979
Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat.
    Japanese journal of pharmacology, 1979, Volume: 29, Issue:4

    Topics: Aluminum Hydroxide; Amylopectin; Animals; Anti-Ulcer Agents; Atropine; Chlorpromazine; Hexamethonium

1979
The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat.
    Japanese journal of pharmacology, 1979, Volume: 29, Issue:5

    Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Animals; Cortisone; Desoxycorticosterone; Epinephrin

1979
[Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1979, Volume: 75, Issue:8

    Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Digestive Sy

1979
Studies on indomethacin-induced gastric mucosal erosions and their inhibition by 16, 16 dimethyl prostaglandin E2 in the rat [proceedings].
    British journal of pharmacology, 1977, Volume: 61, Issue:3

    Topics: Animals; In Vitro Techniques; Indomethacin; Prostaglandins E; Rats; Stomach Ulcer

1977
The gastric mucosal microcirculation during erosion formation in the rat.
    Bibliotheca anatomica, 1977, Issue:16 Pt 2

    Topics: Animals; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Microcirculation; Rats; Regional Blood Flo

1977
Gastro-colic fistula secondary to benign gastric ulceration.
    Postgraduate medical journal, 1978, Volume: 54, Issue:630

    Topics: Aged; Colonic Diseases; Female; Gastric Fistula; Humans; Indomethacin; Intestinal Fistula; Peptic Ul

1978
Influence of surgical sympathectomy on gastric secretion and ulceration in rats.
    Japanese journal of pharmacology, 1978, Volume: 28, Issue:2

    Topics: Acetates; Animals; Aspirin; Digestive System; Gastric Juice; Indomethacin; Male; Rats; Reserpine; Se

1978
Effects of cold or restraint on incidence of gastric ulceration induced in rats by ulcerogenic drugs.
    European journal of pharmacology, 1978, Sep-01, Volume: 51, Issue:1

    Topics: Animals; Aspirin; Cimetidine; Cold Temperature; Female; Histamine; Indomethacin; Male; Phenylbutazon

1978
Resistance of the guinea pig to indomethacin ulcerogenesis.
    Toxicology and applied pharmacology, 1978, Volume: 45, Issue:2

    Topics: Animals; Drug Resistance; Duodenal Ulcer; Guinea Pigs; Indomethacin; Lethal Dose 50; Male; Peptic Ul

1978
Release of inflammatory mediators into the gastric wall of rats with acute acetic acid induced ulcer.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1978, Volume: 10, Issue:5

    Topics: Acetates; Acute Disease; Animals; Capillary Permeability; Gastric Mucosa; Gastritis; Indomethacin; M

1978
Aspirin- and indomethacin-induced ulcers and their antagonism by antihistamines.
    European journal of pharmacology, 1978, Oct-01, Volume: 51, Issue:3

    Topics: Animals; Aspirin; Cold Temperature; Corticosterone; Histamine Antagonists; Indomethacin; Male; Rats;

1978
[Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1978, Volume: 74, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Beclomethasone; Betamethasone; Betamethasone Valerate; C

1978
[Comparative studies on gastrointestinal damage induced by non-steroidal anti-inflammatory drugs in rats (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1978, Volume: 98, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dose-Response Relationship, Drug; Flurbiprofen; Indometh

1978
Distention ulcer as a model for testing of drugs for ulcerogenic side effects.
    Archives of toxicology, 1978, Oct-13, Volume: 41, Issue:1

    Topics: Animals; Aspirin; Disease Models, Animal; Hydrochloric Acid; Indomethacin; Male; Rats; Stomach; Stom

1978
Synthesis and gastrointestinal pharmacology of some 15- and 16- modified (+/-)-11-deoxyprostaglandins.
    Prostaglandins, 1978, Volume: 16, Issue:4

    Topics: Animals; Chemical Phenomena; Chemistry; Constipation; Digestive System; Drug Evaluation, Preclinical

1978
[Indomethacin and substance VUFB 12018 (Tropesin SPOFA). A comparison of their side effects on the gastrointestinal tract of rats].
    Ceskoslovenska farmacie, 1978, Volume: 27, Issue:7

    Topics: Animals; Gastric Mucosa; Indomethacin; Male; Rats; Stomach Ulcer

1978
Effects of various amino acids on indomethacin-induced gastric ulcers in rats.
    Japanese journal of pharmacology, 1977, Volume: 27, Issue:2

    Topics: Amino Acids; Animals; Indomethacin; Male; Rats; Stomach Ulcer

1977
Effect of salbumatol on acute gastric ulceration induced by indomethacin in the rat.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1977, Volume: 9, Issue:4

    Topics: Acute Disease; Albuterol; Animals; Indomethacin; Male; Rats; Stomach Ulcer

1977
Prostaglandin and norepinephrine metabolism: effect of indomethacin on prostaglandin synthesis and norepinephrine turnover rate.
    Japanese journal of pharmacology, 1977, Volume: 27, Issue:3

    Topics: Animals; Depression, Chemical; Gastric Mucosa; Indomethacin; Male; Norepinephrine; Prostaglandins; R

1977
The anti-inflammatory profile of proquazone.
    Archives internationales de pharmacodynamie et de therapie, 1976, Volume: 221, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Granuloma; Indomethaci

1976
Effects of new synthetic analogues of prostaglandin E2 on gastric acid secretion and gastric ulceration.
    Advances in prostaglandin and thromboxane research, 1976, Volume: 2

    Topics: Animals; Diarrhea; Dogs; Gastric Mucosa; Humans; Indomethacin; Male; Pentagastrin; Prostaglandins E;

1976
Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats.
    Japanese journal of pharmacology, 1976, Volume: 26, Issue:4

    Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Cortisone; Cyclohexanecarboxylic Acids; Disease Model

1976
[Effects of various drugs on experimental ulcer in the rat].
    Bollettino della Societa italiana di biologia sperimentale, 1976, Aug-15, Volume: 52, Issue:15

    Topics: Animals; Disease Models, Animal; Female; Indomethacin; Peptides; Pyridines; Rats; Stomach Ulcer

1976
Gastric damage by drugs and the role of the mucosal barrier.
    Australian and New Zealand journal of medicine, 1976, Volume: 6 Suppl 1

    Topics: Animals; Aspirin; Dogs; Ethanol; Gastric Mucins; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans

1976
Decreased incidence of indomethacin-induced gastric ulceration in rats by bile duct diversion.
    The British journal of surgery, 1975, Volume: 62, Issue:2

    Topics: Ampulla of Vater; Animals; Bile Ducts; Female; Indomethacin; Injections, Intraperitoneal; Male; Rats

1975
Proceedings: Salbutamol: inhibition of gastric ulceration in the rat.
    The British journal of surgery, 1975, Volume: 62, Issue:2

    Topics: Albuterol; Animals; Indomethacin; Rats; Stomach; Stomach Ulcer

1975
Floctafenine, a new non-narcotic analgesic.
    Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 216, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Dextropropoxyphene; D

1975
[Gastric ulcer induced in the rat by non-steroid anti-inflammatory agents and the synergic effect of exogenous histamine].
    Bollettino chimico farmaceutico, 1975, Volume: 114, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Drug Synergism; Flufenamic Acid; Histamine; Indomethacin

1975
Some pharmacological properties of 2-aryl-1,3-indandione derivatives.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticoagulants; Antitussive Agents; Drug Evaluation,

1975
Proceedings: Gastric acidity and the mechanisms by which prostaglandins prevent indomethacin-induced gastric erosions.
    British journal of pharmacology, 1975, Volume: 55, Issue:2

    Topics: Animals; Gastric Juice; Indomethacin; Prostaglandins; Rats; Stomach Ulcer

1975
Drugs and gastric damage.
    Drugs, 1976, Volume: 11, Issue:1

    Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and

1976
Effect of sialoadenectomy on stomach lesions induced by indomethacin and ethanol in relation to gastric vascular permeability, the gastrin level and HCl secretion in rats.
    Physiological research, 1992, Volume: 41, Issue:5

    Topics: Animals; Capillary Permeability; Epidermal Growth Factor; Ethanol; Gastrins; Hydrochloric Acid; Indo

1992
[Effect of circadian rhythm on the action of acupuncture to prevent the formation of experimental gastric ulcer].
    Zhen ci yan jiu = Acupuncture research, 1992, Volume: 17, Issue:2

    Topics: Acupuncture Therapy; Alprostadil; Animals; Circadian Rhythm; Dinoprost; Gastric Mucosa; Indomethacin

1992
Studies on gastroprotection induced by capsaicin and papaverine.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1992, Volume: 43, Issue:4

    Topics: Animals; Arginine; Capsaicin; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Nitroarginine; Pa

1992
Influence of cloprostenol in the experimentally induced ulcer in rats.
    Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 1992, Volume: 96 Suppl

    Topics: Animals; Cloprostenol; Disease Models, Animal; Drug Evaluation, Preclinical; Indomethacin; Male; Rat

1992
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.
    Inflammation, 1992, Volume: 16, Issue:3

    Topics: 5-Lipoxygenase-Activating Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants;

1992
Is acute surgical vagotomy an aggressor to gastric mucosa in pylorus ligated rats with and without indomethacin treatment?
    Acta physiologica Hungarica, 1992, Volume: 80, Issue:1-4

    Topics: Animals; Dinoprostone; Gastric Mucosa; Indomethacin; Pylorus; Rats; Rats, Sprague-Dawley; Stomach Ul

1992
Correlation between the cytoprotective effect of beta-carotene and its gastric mucosal level in indomethacin (IND) treated rats with or without acute surgical vagotomy.
    Acta physiologica Hungarica, 1992, Volume: 80, Issue:1-4

    Topics: Animals; beta Carotene; Carotenoids; Chromatography, High Pressure Liquid; Female; Gastric Mucosa; I

1992
Synthesis and gastroprotective activity of 4H-pyrido[1,2-a]pyrimidin-4-ones.
    Acta physiologica Hungarica, 1992, Volume: 80, Issue:1-4

    Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Decision Trees; Ethanol; Indomethacin; Pyrimidinon

1992
Gastric anti-ulcerogenic drug effect. A possible mechanism of its molecular basis.
    Acta physiologica Hungarica, 1992, Volume: 80, Issue:1-4

    Topics: Animals; Anti-Ulcer Agents; Cimetidine; Cyclic AMP; Cyclic GMP; Epoprostenol; Female; Indomethacin;

1992
Reduction of adverse effects of indomethacin by anti-allergic drugs in rat stomachs.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:9

    Topics: Animals; Gastric Acid; Gastric Mucosa; Histamine Antagonists; Histamine H1 Antagonists; Indomethacin

1992
[Study on pilules of indomethacin--PEG 6000].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1992, Volume: 27, Issue:3

    Topics: Animals; Drug Carriers; Gastric Acid; Indomethacin; Male; Polyethylene Glycols; Rats; Rats, Inbred S

1992
Anti-inflammatory, analgesic, and antipyretic effects and gastrointestinal toxicity of the new anti-inflammatory drug N-(3-[3-(piperidinylmethyl)phenoxy]propyl)-carbamoylmethylthio ]ethyl 1-(p-chlorobenzoyl) 5-methoxy-2-methyl-3-indolylacetate.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capillary Permeability; E

1992
Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury.
    Scandinavian journal of gastroenterology, 1992, Volume: 27, Issue:8

    Topics: Acute Disease; Animals; Blood Flow Velocity; Epidermal Growth Factor; Gastric Mucosa; Indomethacin;

1992
Possible involvement of hyperinsulinemia and adrenergic activation in the pathogenesis of indomethacin-induced antral ulcers in nonfasted hamsters and refed rats.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3

    Topics: Animals; Atropine; Cricetinae; Famotidine; Fasting; Indomethacin; Insulin; Male; Mesocricetus; Prazo

1992
Effects of sulfhydryl-related compounds on indomethacin-induced gastric lesions in rats: role of endogenous sulfhydryls in the pathogenesis.
    Japanese journal of pharmacology, 1992, Volume: 58, Issue:2

    Topics: Animals; Gastric Acidity Determination; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strai

1992
Synthesis and antiulcer activity of novel 5-(2-ethenyl substituted)-3(2H)-furanones.
    Journal of medicinal chemistry, 1992, Apr-03, Volume: 35, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Ethanol; Furans; Indomethacin; Male; Molecular Str

1992
Effects of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on platelet aggregation and thrombosis in experimental animals.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:1

    Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Bridged Bicyclo Compounds; Cyclooxygenase

1992
Role of nitric oxide and prostaglandins in sucralfate-induced gastroprotection.
    European journal of pharmacology, 1992, Feb-11, Volume: 211, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Arginine; Ethanol; Indomethacin; Male; Nitric Oxide; Nitroarginine; Pros

1992
Steroid ulcers.
    BMJ (Clinical research ed.), 1992, May-30, Volume: 304, Issue:6839

    Topics: Animals; Indomethacin; Prednisolone; Rats; Stomach Ulcer; Wound Healing

1992
Pharmacological profile of UP 5145-52, an original antiulcer and antisecretory agent.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:1

    Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Anti-Ulcer Agents; Dose-Response Relations

1991
[The part of lysosomal enzymes in drug-induced ulcerogenesis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 111, Issue:4

    Topics: Animals; Aspirin; Cathepsins; Deoxyribonucleases; Indomethacin; Lysosomes; Male; Phenylbutazone; Qui

1991
Effect of unmodified eel calcitonin on gastric acid secretion and gastric ulcers in the rat.
    Farmaco (Societa chimica italiana : 1989), 1991, Volume: 46, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Calcitonin; Cold Temperature; Cystamine; Gastric Acid; Indomethacin; Mal

1991
Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats.
    Agents and actions, 1991, Volume: 33, Issue:3-4

    Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Gastric Acid; Gastric Mucosa; Histamine H1 Antagonist

1991
Improvement of absorption rate of indomethacin and reduction of stomach irritation by alginate dispersions.
    The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:9

    Topics: Administration, Oral; Adult; Alginates; Animals; Chemistry, Pharmaceutical; Dogs; Humans; Indomethac

1991
Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing.
    Lancet (London, England), 1990, Oct-06, Volume: 336, Issue:8719

    Topics: Adult; Aged; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell

1990
Gastric mucosal protection induced by restraint and water-immersion stress in rats.
    Japanese journal of pharmacology, 1990, Volume: 54, Issue:3

    Topics: Animals; Atropine; Dinoprostone; Electric Stimulation; Ethanol; Gastric Mucosa; Immersion; Indometha

1990
Momentum omentum!
    Gastroenterology, 1992, Volume: 102, Issue:1

    Topics: Animals; Chronic Disease; Gastric Mucosa; Indomethacin; Omentum; Rats; Regional Blood Flow; Stomach

1992
Antiulcerogenic effects of two Maytenus species in laboratory animals.
    Journal of ethnopharmacology, 1991, Volume: 34, Issue:1

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Cold Temperature; Gastric Acid

1991
Intragastric pH in the gastroprotective and ulcer-healing activity of aluminum-containing antacids.
    Digestion, 1991, Volume: 49, Issue:3

    Topics: Acute Disease; Aluminum Hydroxide; Animals; Antacids; Chronic Disease; Drug Combinations; Ethanol; F

1991
Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility.
    Digestion, 1991, Volume: 49, Issue:3

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Atropine; Capillary Permeability; Free Radicals; Gastric Mu

1991
Gastroprotective effect of nitrendipine on stress-induced gastric lesions in rats.
    Pharmacology, 1991, Volume: 43, Issue:4

    Topics: Animals; Cold Temperature; Dexamethasone; Female; Immobilization; Indomethacin; Male; Nitrendipine;

1991
Dose-dependent effects of fentanyl on indomethacin-induced gastric damage.
    Digestion, 1991, Volume: 49, Issue:4

    Topics: Animals; Atropine; Butyrophenones; Dose-Response Relationship, Drug; Drug Combinations; Fentanyl; Ga

1991
Possibilities to reduce the unwanted gastric side-effects of orally administered indomethacin in the rat.
    The Kitasato archives of experimental medicine, 1991, Volume: 64, Issue:1

    Topics: Administration, Oral; Animals; Cysteine; Epoprostenol; Female; Gastrointestinal Hemorrhage; Indometh

1991
Protection by acidified Maalox against indomethacin-induced gastric antral ulceration in hamsters.
    Digestion, 1991, Volume: 50, Issue:1

    Topics: Aluminum Hydroxide; Animals; Antacids; Cricetinae; Drug Combinations; Hydrogen-Ion Concentration; In

1991
Protection against alcohol-induced gastric mucosal injury by nitecapone.
    General pharmacology, 1991, Volume: 22, Issue:6

    Topics: Animals; Anti-Ulcer Agents; Catechols; Ethanol; Gastric Mucosa; Hydrogen; Indomethacin; Male; Mucins

1991
Reduction of non-steroidal anti-inflammatory drug induced gastric damage in the rat by soluble pepstatin derivatives.
    Advances in experimental medicine and biology, 1991, Volume: 306

    Topics: Amino Acid Sequence; Animals; Female; Indomethacin; Molecular Sequence Data; Pepsin A; Pepstatins; R

1991
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary

1991
The effect of CV-3988 and CV-6209 on the acute gastric erosions of rats due to water-immersion and restraint stress.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Analysis of Variance; Animals; Gastric Mucosa; Immersion; Indomethacin; Male; Phospholipid Ethers; P

1991
Effects of a new benzimidazole derivative, NC-1300-O-3, on gastric secretion and gastroduodenal lesions in rats.
    Japanese journal of pharmacology, 1991, Volume: 55, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Benz

1991
Interactions between the vascular peptide endothelin-1 and sensory neuropeptides in gastric mucosal injury.
    British journal of pharmacology, 1991, Volume: 102, Issue:4

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Endothelins; Gastric Mucosa; Gastrointestinal H

1991
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1

    Topics: Allopurinol; Animals; Catalase; Chromium Radioisotopes; Deferoxamine; Free Radical Scavengers; Free

1991
BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat.
    European journal of pharmacology, 1991, Mar-26, Volume: 195, Issue:2

    Topics: Adrenalectomy; Animals; Anti-Ulcer Agents; Benzimidazoles; Cimetidine; Corticosterone; Cysteamine; D

1991
Solcoseryl in prevention of stress-induced gastric lesions and healing of chronic ulcers.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1991, Volume: 42, Issue:1

    Topics: Actihaemyl; Analysis of Variance; Animals; Dinoprostone; Eflornithine; Epidermal Growth Factor; Gast

1991
Lack of vitamin E cytoprotective effects on indomethacin-induced gastric lesions.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 72, Issue:3

    Topics: Animals; Duodenum; Gastric Mucosa; Indomethacin; Liver; Male; Oxidation-Reduction; Random Allocation

1991
Gastric and jejunal ultrastructure in capsaicin-treated rats with and without experimental ulcer.
    Advances in experimental medicine and biology, 1991, Volume: 298

    Topics: Animals; Capsaicin; Denervation; Ethanol; Gastric Mucosa; Indomethacin; Jejunum; Male; Microscopy, E

1991
Gastric mucosal protection by sucralfate involves phosphoinositides participation.
    The International journal of biochemistry, 1990, Volume: 22, Issue:10

    Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; M

1990
Effects of the new H2-receptor antagonist 3-amino-4-[4- [4- (1-piperidinomethyl)-2-pyridyloxy]-cis-2-butenylamino]-3-cyclobutene-1, 2- dione hydrochloride on gastric acid secretion and ulceration.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Cold Temperature; Cysteamine; Duodenal Ulcer; Gastric Acid; Histamine; H

1990
Possible prostaglandin-dopamine interactions during experimental gastric ulcer formation.
    Indian journal of experimental biology, 1990, Volume: 28, Issue:6

    Topics: Animals; Apomorphine; Bromocriptine; Dopamine; Dopamine Agents; Dopamine Antagonists; Dose-Response

1990
Role of leukotriene C4 in mucosal damage caused by necrotizing agents and indomethacin in the rat stomach.
    Gastroenterology, 1991, Volume: 100, Issue:3

    Topics: Animals; Arachidonate 5-Lipoxygenase; Dinoprostone; Ethanol; Gastric Mucosa; Indoles; Indomethacin;

1991
Effect of indomethacin on opioid-induced gastric protection in cold-restrained stress.
    Life sciences, 1991, Volume: 48, Issue:9

    Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Gastric Mucosa; Indomethacin; Injections, Intraperi

1991
Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats.
    Gastroenterology, 1991, Volume: 100, Issue:5 Pt 1

    Topics: Acetates; Acetic Acid; Animals; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Omeprazole; Rats;

1991
Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d,l-lactide) and poly(isobutyl-cyanoacrylate) nanocapsules in rats.
    Pharmaceutical research, 1991, Volume: 8, Issue:1

    Topics: Animals; Capsules; Chemical Phenomena; Chemistry, Physical; Cyanoacrylates; Enbucrilate; In Vitro Te

1991
[Cell kinetic study on the healing process of indomethacin-induced gastric mucosal lesion of rats].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1991, Volume: 88, Issue:1

    Topics: Animals; Cell Cycle; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; S Phase; Stomac

1991
Antisecretory and anti-ulcer effects of morphine in rats after gastric mucosal aggression.
    European journal of pharmacology, 1991, Jan-10, Volume: 192, Issue:2

    Topics: Animals; Aspirin; Depression, Chemical; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Morphine;

1991
Interleukin-1 inhibits stress-induced gastric erosion in rats.
    Life sciences, 1991, Volume: 48, Issue:23

    Topics: Animals; Indomethacin; Injections, Intravenous; Injections, Intraventricular; Interleukin-1; Male; R

1991
Protection by copper (II) complexes in various models of ulceration in rat.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Copper; Gastric Acid; Hydrochloric Acid; Indomethacin; Male; Rats; Rats,

1991
The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug.
    Agents and actions. Supplements, 1991, Volume: 32

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dogs; Female; Indomethacin; Male; Mice

1991
Relationship between gastric mucosal prostaglandin levels and healing of gastric lesions in rats.
    Clinical and experimental pharmacology & physiology, 1990, Volume: 17, Issue:11

    Topics: Animals; Ethanol; Gastric Mucosa; Indomethacin; Male; Prostaglandins; Rats; Rats, Inbred Strains; St

1990
Protective effect of propranolol on ethanol-induced gastric lesions in mice.
    European journal of pharmacology, 1990, Nov-27, Volume: 191, Issue:2

    Topics: Administration, Oral; Animals; Ethanol; Gastrointestinal Hemorrhage; Indomethacin; Injections, Intra

1990
Effects of a crude extract of a marine dinoflagellate, containing dimethyl-beta-propiothetin, on HCl.ethanol-induced gastric lesions and gastric secretion in rats.
    Japanese journal of pharmacology, 1990, Volume: 54, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Eukaryota; Gastric Mucosa; Hy

1990
Research on heterocyclic compounds. XXVII. Synthesis and antiinflammatory activity of 2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acids.
    Farmaco (Societa chimica italiana : 1989), 1990, Volume: 45, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Edema; Female; Human

1990
Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat.
    British journal of pharmacology, 1990, Volume: 99, Issue:3

    Topics: Animals; Arginine; Blood Pressure; Capsaicin; Epoprostenol; Gastric Mucosa; Indomethacin; Male; Neur

1990
Role of arachidonic acid metabolites in acute gastric lesions induced by indomethacin in rats.
    Acta physiologica Hungarica, 1990, Volume: 75 Suppl

    Topics: Animals; Arachidonic Acids; Dinoprostone; Epoprostenol; Gastric Mucosa; Indomethacin; Rats; Stomach

1990
The gastroprotective effect of CHINOIN-127 on indomethacin induced gastric ulcer in rats.
    Acta physiologica Hungarica, 1990, Volume: 75 Suppl

    Topics: Animals; Anti-Ulcer Agents; Epoprostenol; Indomethacin; Prostaglandin-Endoperoxide Synthases; Pyrimi

1990
Endogenous prostaglandins: its role in gastric mucosal blood flow and ethanol ulceration in rats.
    Prostaglandins, 1990, Volume: 40, Issue:4

    Topics: Alprostadil; Animals; Blood Flow Velocity; Ethanol; Gastric Mucosa; Indomethacin; Male; Misoprostol;

1990
Pharmacological profile of SK&F 105809, a dual inhibitor of arachidonic acid metabolism.
    Drugs under experimental and clinical research, 1990, Volume: 16, Issue:4

    Topics: Administration, Oral; Analgesics; Animals; Arachidonic Acid; Arachidonic Acids; Arthritis, Experimen

1990
Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process.
    The American journal of physiology, 1990, Volume: 259, Issue:3 Pt 1

    Topics: Animals; Immune Sera; Indomethacin; Leukotriene B4; Male; Methotrexate; Muscle, Smooth; Neutropenia;

1990
Effect of captopril on oxyphenbutazone and ethanol-induced gastric lesions in rats.
    European journal of pharmacology, 1990, Feb-20, Volume: 177, Issue:1-2

    Topics: Animals; Captopril; Ethanol; Indomethacin; Male; Oxyphenbutazone; Rats; Rats, Inbred Strains; Stomac

1990
Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats.
    Japanese journal of pharmacology, 1990, Volume: 54, Issue:1

    Topics: Acetates; Acetic Acid; Animals; Drug Therapy, Combination; Gastric Acid; Histamine; Indomethacin; Ma

1990
[Effect of dry ginger and roasted ginger on experimental gastric ulcers in rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1990, Volume: 15, Issue:5

    Topics: Acetates; Animals; Drugs, Chinese Herbal; Female; Hot Temperature; Indomethacin; Male; Mice; Rats; R

1990
Reduction of the severity of experimental gastric and duodenal ulceration by interleukin-1 beta.
    European journal of pharmacology, 1990, Sep-21, Volume: 186, Issue:2-3

    Topics: Animals; Cysteamine; Duodenal Ulcer; Ethanol; Indomethacin; Injections, Intraperitoneal; Interleukin

1990
Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:1

    Topics: Acetates; Animals; Anti-Ulcer Agents; Epidermal Growth Factor; Gastric Acid; Gastric Fistula; Histam

1990
Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2.
    Digestive diseases and sciences, 1990, Volume: 35, Issue:5

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Ulcer Agents; Carnosine; Dinoprostone; Dipeptides; Eth

1990
Mucosal protective activity of activated aluminum complex.
    Digestion, 1990, Volume: 45, Issue:1

    Topics: Aluminum Hydroxide; Animals; Antacids; Aspirin; Cysteamine; Duodenal Ulcer; Ethanol; Gastric Mucosa;

1990
Effects of liver extract from the ocean sunfish (Mola mola) on acute gastric lesions in the rat.
    Nihon juigaku zasshi. The Japanese journal of veterinary science, 1990, Volume: 52, Issue:2

    Topics: Animals; Cimetidine; Hydrochloric Acid; Indomethacin; Liver Extracts; Male; Perciformes; Rats; Rats,

1990
The use of a thymidine incorporation assay in the evaluation of the healing process following ethanol or indomethacin-induced gastric damage in rats.
    Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:3

    Topics: Animals; DNA; Ethanol; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; Stomach Ulcer

1990
Gastric antiulcer and cytoprotective effects of dipyridamole in rats.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:3

    Topics: Animals; Dipyridamole; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strai

1990
Gastroprotective effect of meclofenamic acid on indomethacin-induced ulceration in rats.
    Acta physiologica Hungarica, 1990, Volume: 75 Suppl

    Topics: Animals; Gastric Mucosa; Indomethacin; Meclofenamic Acid; ortho-Aminobenzoates; Rats; SRS-A; Stomach

1990
Possible mechanisms involved in gastric hypermotility caused by indomethacin in the rat. Role of glycoprivic response.
    Digestive diseases and sciences, 1990, Volume: 35, Issue:8

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Blood Glucose; Dose-Response Relationship, Drug; Drug Inter

1990
The effect of long-term prostacyclin treatment on the protein, DNA and RNA content of rat gastric fundic mucosa.
    Agents and actions, 1985, Volume: 16, Issue:5

    Topics: Animals; DNA; Epoprostenol; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Proteins; Rats; Ra

1985
Gastric antral and fundic mucosal protein, DNA and RNA changes in different experimental ulcer models.
    Agents and actions, 1985, Volume: 17, Issue:1

    Topics: Animals; Disease Models, Animal; DNA; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Proteins

1985
Protective effect of iloprost and UK 38 485 against gastric mucosal damage induced by various stimuli.
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 30, Issue:2-3

    Topics: Animals; Epoprostenol; Ethanol; Female; Gastric Mucosa; Iloprost; Imidazoles; Indomethacin; Male; Ra

1987
Cardiopulmonary and gastric ulcerogenic actions of endothelin-1 in the guinea pig and rat.
    Journal of cardiovascular pharmacology, 1989, Volume: 13 Suppl 5

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Endothelins; Gastric Mucosa; Guinea Pigs; Heart Rat

1989
Microscopic correlates of adaptive cytoprotection in an ethanol injury model.
    Histology and histopathology, 1989, Volume: 4, Issue:1

    Topics: Animals; Ethanol; Female; Gastric Mucosa; Indomethacin; Irritants; Rats; Rats, Inbred Strains; Stoma

1989
Gastric antisecretory and antiulcer/cytoprotective effects of 2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:5

    Topics: Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cyanoacrylates; Ethanol;

1989
The effect of prostacyclin treatment on the changes of cyclic nucleotide levels of rat antral and fundic gastric mucosa in different experimental ulcer models.
    The Japanese journal of experimental medicine, 1989, Volume: 59, Issue:3

    Topics: Animals; Cyclic AMP; Cyclic GMP; Epoprostenol; Gastric Fundus; Gastric Mucosa; Indomethacin; Pyloric

1989
Effect of epidermal growth factor on non-steroidal anti-inflammatory drug-induced intestinal damage.
    Agents and actions, 1989, Volume: 27, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dimaprit; Epidermal Growth Factor; Ethanol; Gastri

1989
Gastroprotective activity of ginger zingiber officinale rosc., in albino rats.
    The American journal of Chinese medicine, 1989, Volume: 17, Issue:1-2

    Topics: Animals; Aspirin; Drugs, Chinese Herbal; Ethanol; Female; Hydrochloric Acid; Indomethacin; Male; Rat

1989
Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
    Scandinavian journal of gastroenterology. Supplement, 1989, Volume: 162

    Topics: Acetates; Acetic Acid; Animals; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gastric A

1989
Effects of ALE-36 on gastric secretion, and gastric and duodenal ulcers induced in rats.
    Scandinavian journal of gastroenterology. Supplement, 1989, Volume: 162

    Topics: Animals; Benzimidazoles; Chlorides; Dose-Response Relationship, Drug; Duodenal Ulcer; Gastric Juice;

1989
The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats.
    Scandinavian journal of gastroenterology. Supplement, 1989, Volume: 162

    Topics: Animals; Biomechanical Phenomena; Gastric Mucosa; Indomethacin; Male; Omeprazole; Prostaglandin D2;

1989
[The role of sulfhydryls in indomethacin-induced gastric mucosal injury in rats].
    Sheng li xue bao : [Acta physiologica Sinica], 1989, Volume: 41, Issue:5

    Topics: Animals; Cysteamine; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; S

1989
Comparative antiulcer and antisecretory effects of various calcium antagonists.
    General pharmacology, 1989, Volume: 20, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Calcium Channel Blockers; Ethanol; Gastric Acid; Gastric Mucosa; Indicat

1989
Circadian rhythms of food intake in gastroduodenally-ulcerated rats: effects of three anti-ulcer drugs.
    Chronobiology international, 1989, Volume: 6, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Circadian Rhythm; Duodenal Ulcer; Eating; Female; Indomethacin; Male; Pi

1989
Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach.
    The American journal of physiology, 1989, Volume: 256, Issue:4 Pt 1

    Topics: Animals; Blood Pressure; Diterpenes; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vas

1989
Up-regulation of prostaglandin E2 binding and of prostanoid release in rabbits producing antibodies against prostaglandin E2.
    Prostaglandins, 1989, Volume: 38, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antibody Formation; Arachidonic Acids; Dinoprostone; Epoprost

1989
Neomycin prevents indomethacin-induced gastric peristalsis and mucosal injury in the rat.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:9

    Topics: Animals; Bacitracin; Blood Glucose; Female; Gastric Mucosa; Gastrointestinal Motility; Indomethacin;

1989
Influence of indomethacin amphoteric gel on gastric ulcerogenicity and absorption of indomethacin in rats.
    Pharmaceutical research, 1989, Volume: 6, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressur

1989
Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:2

    Topics: Animals; Antioxidants; Azoles; Ethanol; Gastric Mucosa; Indomethacin; Isoindoles; Male; Necrosis; Or

1989
Effects of NC-1300, a gastric proton pump inhibitor, on healing of acetic acid-induced gastric ulcers in rats.
    Digestive diseases and sciences, 1989, Volume: 34, Issue:7

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Administration, Oral; Animals; Anti-Ulcer Agents;

1989
Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat. Role of enhanced gastric motility.
    Gastroenterology, 1989, Volume: 97, Issue:2

    Topics: Adrenalectomy; Animals; Blood Glucose; Gastric Acid; Gastric Mucosa; Gastrointestinal Motility; Gluc

1989
Lipid peroxidation in normal and ulcerated gastric mucosa of rats treated with pentacaine and cimetidine.
    Agents and actions, 1989, Volume: 27, Issue:1-2

    Topics: Animals; Carbamates; Cimetidine; Ethanol; Gastric Mucosa; Indomethacin; Lipid Peroxidation; Male; Ma

1989
Effects of fish oil on gastric mucosal 6-keto-PGF1 alpha synthesis and ethanol-induced injury.
    The American journal of physiology, 1989, Volume: 257, Issue:1 Pt 1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Ethanol; Female; Fish Oils; Gastric Mucosa; Indomethacin; Rat

1989
Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:6

    Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Epirizole; Ethanol; Gastric Acid; Gastric Mucosa; Imm

1989
Cytoprotective and antiulcer activities of the antacid magaldrate in the rat.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:7

    Topics: Aluminum Hydroxide; Animals; Antacids; Anti-Ulcer Agents; Aspirin; Cell Survival; Cysteamine; Dinopr

1989
The pharmacological profile of CGP 28238, a highly potent anti-inflammatory compound.
    Agents and actions, 1989, Volume: 26, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Gastrointestinal H

1989
Effect of parathyroid hormone, centrally or peripherally injected, on gastric activity in male rats.
    European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3

    Topics: Animals; Ethanol; Gastric Acid; Indomethacin; Injections, Intravenous; Injections, Intraventricular;

1989
Reduction of indomethacin induced gastroduodenal mucosal injury and gastrointestinal symptoms with cimetidine in normal subjects.
    The Journal of rheumatology, 1989, Volume: 16, Issue:9

    Topics: Adolescent; Adult; Cimetidine; Digestive System; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; H

1989
A possible mechanism for the gastric mucosal protection by oren-gedoku-to (OGT), a traditional herbal medicine.
    Japanese journal of pharmacology, 1989, Volume: 51, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Drugs, Chinese Herbal; Ethanol; Ethylmaleimide; Glutathione; Indomethaci

1989
Exacerbation of indomethacin-induced gastric ulceration by systemically administered GABA in rats: possible involvement of peripheral GABA receptors.
    Japanese journal of pharmacology, 1988, Volume: 47, Issue:4

    Topics: Animals; Anticonvulsants; Atropine; beta-Alanine; Bicuculline; Drug Synergism; gamma-Aminobutyric Ac

1988
Effects of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)-acetoxyacetamide hydrochloride (TZU-0460), a histamine H2-receptor antagonist, on gastric acid secretion and ulcer formation.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Cysteamine; Dogs; Gastric Acid; Histamine; Histamine

1985
Cytoprotective action of carbenoxolone sodium on ethanol-induced gastric lesions in rats and its inhibition by indomethacin.
    The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:10

    Topics: Animals; Carbenoxolone; Ethanol; Glycyrrhetinic Acid; Indomethacin; Male; Rats; Rats, Inbred Strains

1985
Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer.
    Lancet (London, England), 1986, Mar-01, Volume: 1, Issue:8479

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Duodenal Ulcer; Female; Humans; Ibuprofen; Indome

1986
Sulphasalazine and experimental stress ulcers.
    Agents and actions, 1985, Volume: 17, Issue:2

    Topics: Administration, Oral; Animals; Dinoprostone; Female; Indomethacin; Injections, Subcutaneous; Prostag

1985
Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Clonidine; Cysteamine; Di

1987
The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats.
    European journal of pharmacology, 1988, Dec-06, Volume: 158, Issue:1-2

    Topics: Animals; Anti-Ulcer Agents; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Female; Gastri

1988
Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin.
    Gastroenterology, 1989, Volume: 96, Issue:2 Pt 1

    Topics: Acetates; Acetic Acid; Animals; Dinoprostone; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Rats

1989
The mechanism of acute gastric ulcer after induced hemorrhagic shock.
    Scandinavian journal of gastroenterology, 1989, Volume: 24, Issue:2

    Topics: Acute Disease; Animals; Blood Pressure; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Norepineph

1989
Gastric anti-ulcer and cytoprotective effect of selenium in rats.
    Toxicology and applied pharmacology, 1988, Volume: 92, Issue:1

    Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Dimaprit; Ethanol; Female; Gastric Acid; Gastric

1988
Comparison of the ulcerogenicity of indomethacin and the gastric secretion in verapamil-treated rats.
    Physiologia Bohemoslovaca, 1988, Volume: 37, Issue:6

    Topics: Animals; Dose-Response Relationship, Drug; Gastric Juice; Gastric Mucosa; Hydrochloric Acid; Hydroge

1988
Changes of cAMP and cGMP levels of rat antral and fundic gastric mucosa in different ulcer models.
    Biochemical medicine and metabolic biology, 1987, Volume: 37, Issue:1

    Topics: Animals; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Female; Gastric Fundus; Gastric Mucosa; Ind

1987
Relative roles of acid and mucosal compression in ulcerogenesis in indomethacin-insulin-treated rat.
    Digestive diseases and sciences, 1988, Volume: 33, Issue:11

    Topics: Animals; Cimetidine; Female; Gastric Acid; Gastrointestinal Motility; Indomethacin; Insulin; Rats; S

1988
[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 88, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidoni

1986
Protection by mild irritants against indomethacin-induced gastric mucosal damage in the rat: role of prostaglandin synthesis.
    Israel journal of medical sciences, 1986, Volume: 22, Issue:11

    Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Animals; Dinoprostone; Ethanol; Gastric Acid; Gastric M

1986
Cytoprotective action of mast cell stabilizers against ethanol-induced gastric lesions in rats.
    Japanese journal of pharmacology, 1986, Volume: 42, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Bicarbonates; Chromones; Cromolyn Sodium; Ethanol; Gastric Acid; Gastric

1986
Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 2nd communication: inhibitory effects on acute inflammation and prostaglandin-related reactions.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Benzopyrans; Benzothiepins;

1986
[Study on the effect of oxygenation under high pressure (OHP) on the rat gastric mucosa].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1987, Volume: 84, Issue:6

    Topics: Animals; Gastric Mucosa; Hyperbaric Oxygenation; Indomethacin; Male; Pepsin A; Rats; Rats, Inbred St

1987
[Protection by acupuncture on gastric mucosal damage in rats].
    Zhen ci yan jiu = Acupuncture research, 1987, Volume: 12, Issue:3

    Topics: Acupuncture Therapy; Animals; Electric Stimulation Therapy; Female; Gastric Mucosa; Indomethacin; Ma

1987
Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: effects on gastric acid secretion and stress-induced mucosal damage.
    Gastroenterology, 1988, Volume: 95, Issue:1

    Topics: Animals; Diet; Dinoprostone; Female; Fistula; Gastric Juice; Gastric Mucosa; Indomethacin; Ligation;

1988
Indomethacin-induced gastric antral ulcers in hamsters.
    Gastroenterology, 1988, Volume: 95, Issue:4

    Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal

1988
Is the gastric lesion correlated with the inhibition of tissular peroxidase activity induced by indomethacin?
    Cellular and molecular biology, 1988, Volume: 34, Issue:4

    Topics: Animals; Gastric Mucosa; Indomethacin; Kinetics; Neutrophils; Parietal Cells, Gastric; Peroxidases;

1988
Further studies on the role of the adrenals in the capsaicin-sensitive "gastric defence mechanism".
    International journal of tissue reactions, 1988, Volume: 10, Issue:4

    Topics: Adrenal Glands; Animals; Aspirin; Capsaicin; Drug Synergism; Ethanol; Indomethacin; Rats; Rats, Inbr

1988
[Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure].
    Il Farmaco; edizione scientifica, 1988, Volume: 43, Issue:11

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Indomethacin; M

1988
Analgesic profile of rimazolium as compared to different classes of pain killers.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cats; Dogs; Drug Toleranc

1988
Relationship between the gastric myoelectric and mechanical activity in the genesis of ulcers in indomethacin-insulin-treated rats.
    Digestive diseases and sciences, 1988, Volume: 33, Issue:2

    Topics: Animals; Blood Glucose; Cats; Electromyography; Female; Indomethacin; Insulin; Peristalsis; Rats; Ra

1988
Gastric mucosal calmodulin changes in different experimental ulcer models of rat.
    Biochemical medicine and metabolic biology, 1987, Volume: 38, Issue:1

    Topics: Animals; Calmodulin; Epoprostenol; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Kinetics; P

1987
Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats.
    Digestive diseases and sciences, 1988, Volume: 33, Issue:2

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Atropine; Bicarbonates; Cimetidine; Gastric Acid; Gastric M

1988
Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats.
    Arthritis and rheumatism, 1988, Volume: 31, Issue:3

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Administration, Oral; Animals; Biological Availability; Freeze F

1988
Gastric anti-ulcer and cytoprotective effect of vitamin E in rats.
    Research communications in chemical pathology and pharmacology, 1988, Volume: 60, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Cell Survival; Cold Temperature; Female; Gastric Mucosa; Indomethacin; M

1988
Indomethacin potentiates endotoxin-induced blood flow reduction and histological injury in rat gastric mucosa.
    British journal of pharmacology, 1988, Volume: 93, Issue:4

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Gastric Mucos

1988
Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat.
    Gastroenterology, 1988, Volume: 95, Issue:3

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Autoradiography; Body Weight; Gastric Mucosa; Gastrins; Ind

1988
Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Indomethacin; In

1988
Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 289, Issue:1

    Topics: Animals; Drug Synergism; Female; Indomethacin; Male; Morphine; Rats; Rats, Inbred Strains; Stomach U

1987
Effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl)phenyl] propionic acid hydrochloride on gastric mucosa directly from the lumen.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:11

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Autoradiography; Gastric Mucosa; Indomethacin; Inf

1987
[Effect of intracerebroventricular injection of bombesin on indomethacin-induced gastric ulcer in rats].
    Sheng li xue bao : [Acta physiologica Sinica], 1987, Volume: 39, Issue:5

    Topics: Animals; Bombesin; Indomethacin; Injections, Intraventricular; Male; Rats; Stomach Ulcer; Thalamus

1987
Oxygen free radicals interact with indomethacin to cause gastrointestinal injury.
    Agents and actions, 1986, Volume: 17, Issue:5-6

    Topics: Animals; Anti-Inflammatory Agents; Butylated Hydroxytoluene; Digestive System; Dinoprostone; Ethanol

1986
Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:10

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprostone; Gastric Mucosa; Gastrointestinal Motility; Indo

1986
Synthesis of prostaglandin E2, thromboxane B2 and prostaglandin catabolism in gastritis and gastric ulcer.
    Gut, 1986, Volume: 27, Issue:12

    Topics: Dinoprostone; Female; Gastric Mucosa; Gastritis; Humans; Indomethacin; Male; Prostaglandin Antagonis

1986
Further evidence for gastroprotection induced by aluminium hydroxide in the rat.
    Zeitschrift fur Gastroenterologie, 1986, Volume: 24, Issue:12

    Topics: Aluminum Hydroxide; Animals; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Prostaglandi

1986
Gastric mucosal protection by agents altering gastric mucosal sulfhydryls. Role of endogenous prostaglandins.
    Digestion, 1987, Volume: 37, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Cysteamine; Dinoprostone; Female; Gastric Mucosa; Indomethacin; Male; Ma

1987
Role of mucus and prostaglandins in the gastric mucosal protective actions of sucralfate against ethanol-induced injury in the rat.
    The American journal of medicine, 1987, Sep-28, Volume: 83, Issue:3B

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Mu

1987
Gastric mucosa protective effects of colloidal bismuth subcitrate (DE-NOL).
    International journal of tissue reactions, 1987, Volume: 9, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Dinoprostone; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Organ

1987
Antiulcer activity of clonidine: lack of effect on gastric prostaglandins.
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 30, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Clonidine; Dinoprostone; Female; Gastric Mucosa; Indomethacin

1987
Pharmacological activity of FPP028 (2-phenylpyrazolo-4-ethyl-4,7-dihydro [1,5a]pyrimidin-7-one) a new non-steroid anti-inflammatory agent.
    Pharmacological research communications, 1986, Volume: 18, Issue:3

    Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1986
Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents.
    Drugs under experimental and clinical research, 1987, Volume: 13, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;

1987
Pharmacological properties of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal antiinflammatory agent.
    Agents and actions, 1987, Volume: 21, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Fever; Indomethacin; Inflammation; Pain; Piroxicam

1987
Pharmacological activity of some pyrrolo and pyrazolo pyrimidine derivatives.
    Il Farmaco; edizione scientifica, 1987, Volume: 42, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Humans; In Vitro Techniques; I

1987
Comparative effects of indomethacin and proglumetacin on 6-oxo-PGF1 alpha released ex vivo by rat gastric mucosa.
    International journal of tissue reactions, 1986, Volume: 8, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Epoprostenol; Gastric Mucosa; Indoleacetic Acids; Indomethaci

1986
Eicosanoids and the gastrointestinal tract: promising but no verdict yet.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:3

    Topics: Biliary Tract Diseases; Colitis, Ulcerative; Digestive System; Eicosanoic Acids; Epoprostenol; Human

1986
Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons.
    Gastroenterology, 1986, Volume: 91, Issue:4

    Topics: Animals; Capsaicin; Cysteamine; Dinoprostone; Duodenal Ulcer; Epoprostenol; Ethanol; Female; Gastric

1986
Interaction between prostacyclin and colchicine on the gastric mucosa of rat in different experimental ulcer models.
    Acta physiologica Hungarica, 1986, Volume: 68, Issue:1

    Topics: Animals; Colchicine; Drug Interactions; Epoprostenol; Female; Gastric Mucosa; Indomethacin; Rats; Ra

1986
Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: Animals; Cell Survival; Cimetidine; Cysteamine; Duodenal Ulcer; Female; Gastric Acid; Gastric Mucosa

1987
The effects of the stable thromboxane A2-mimetic, U46619, on gastric mucosal damage and gastric non-parietal secretion in the rat.
    British journal of pharmacology, 1987, Volume: 91, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Ulcer Agents; Biph

1987
Effects of morphine and met-enkephalin analogue on gastric lesions induced by indomethacin.
    Pharmacological research communications, 1987, Volume: 19, Issue:3

    Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Indomethacin; Male; Morphine; Rats; Rats, Inbred St

1987
Efficacy of sucralfate in preventing peptic ulceration induced by nonsteroidal anti-inflammatory drugs.
    The American surgeon, 1987, Volume: 53, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Indomethacin; Male; Peptic Ulcer; Rats; S

1987
Studies on the gastroulcerogenic effects of pylorus ligation, hypothermic restraint stress, aspirin, indomethacin and reserpine in morphine dependent rats.
    Alcohol and drug research, 1987, Volume: 7, Issue:5-6

    Topics: Animals; Aspirin; Gastric Acid; Hypothermia; Indomethacin; Ligation; Male; Morphine Dependence; Pylo

1987
Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats.
    Digestive diseases and sciences, 1987, Volume: 32, Issue:9

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Dose-Response Relationship, Drug; Drug Interactions; Duoden

1987
Milk protection against experimental ulcerogenesis in rats.
    Digestive diseases and sciences, 1987, Volume: 32, Issue:10

    Topics: Animals; Chemical Phenomena; Chemistry, Physical; Cholestyramine Resin; Disease Models, Animal; Gast

1987
Influence of peripherally-administered peptides on ethanol-induced gastric ulcers in the rat.
    General pharmacology, 1987, Volume: 18, Issue:6

    Topics: Animals; Ethanol; Indomethacin; Injections, Subcutaneous; Male; Peptides; Rats; Rats, Inbred Strains

1987
Evidence of "cross-stressor"-induced adaptive gastric cytoprotection.
    Life sciences, 1987, Nov-09, Volume: 41, Issue:19

    Topics: Adaptation, Physiological; Animals; Cold Temperature; Ethanol; Gastric Mucosa; Indomethacin; Male; R

1987
Effects of indomethacin and cold-stress on gastric acid secretion and ulceration. The effects of anti-acid secretory agents in rats.
    Research communications in chemical pathology and pharmacology, 1987, Volume: 57, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Cold Temperature; Gastric Acid; Indomethacin; Ligation; Male; Pylorus; R

1987
[Studies of superoxide dismutase in rat gastric mucosal damage (2d report)--Pathogenesis of indomethacin-induced gastric ulcer].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1987, Volume: 84, Issue:7

    Topics: Animals; Gastric Mucosa; Indomethacin; Male; Rats; Stomach Ulcer; Superoxide Dismutase

1987
Gastrointestinal studies of Pyrenacantha staudtii leaf extracts.
    Journal of ethnopharmacology, 1986, Volume: 15, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Chemical Phenomena; Chemistry; Cold Temperature; Dose-Response Relations

1986
Evidence for a role of adrenals in the capsaicin-sensitive "gastric defence mechanism" in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1986, Volume: 182, Issue:4

    Topics: Adrenal Glands; Adrenalectomy; Animals; Capsaicin; Indomethacin; Male; Rats; Rats, Inbred Strains; S

1986
Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins.
    European journal of pharmacology, 1986, Jun-17, Volume: 125, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Chalcone; Chalcones; Ethanol; Female; Gastric Juice; Indomethac

1986
Protection by metals against ethanol-induced gastric mucosal injury in the rat. Comparative biochemical and pharmacologic studies implicate protein sulfhydryls.
    Gastroenterology, 1986, Volume: 91, Issue:4

    Topics: Animals; Cadmium; Copper; Ethanol; Ethylmaleimide; Female; Gastric Acid; Gastric Mucosa; Indomethaci

1986
Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin.
    Japanese journal of pharmacology, 1986, Volume: 41, Issue:4

    Topics: Animals; Cysteamine; Disease Models, Animal; Drug Synergism; Duodenal Ulcer; Epirizole; Histamine; I

1986
Gastric anti-ulcer and cytoprotective properties of 2-(3,4-dimethoxyphenyl)-5-methyl-thiazolidine-4-one in rat experimental ulcers.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:8

    Topics: Acetates; Animals; Anti-Ulcer Agents; Cell Survival; Cimetidine; Ethanol; Gastric Mucosa; Indomethac

1986
Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa.
    Digestion, 1986, Volume: 35, Issue:3

    Topics: Animals; Diterpenes; Epithelium; Ethanol; Gastric Mucosa; Indomethacin; Male; Membrane Potentials; M

1986
Ulcerogenic and antiulcerogenic effects of a new antiinflammatory drug, the gamma-lactone-N-ethyl derivative of 6-[1S-(3S,4-dihydro-8-hydroxy-1H-2-benzo- pyran-1-one-3-yl)-3-methylbutylamino]-4S,5S-dihydroxy-6-oxo-3S- ammoniohexanoate, on gastrointestinal
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:9

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Coumarins; Gastrointestinal Motility; Indomethacin; Isocoumarin

1986
Cytoprotective effects of NC-1300 and omeprazole on Hcl . ethanol-induced gastric lesions in rats.
    Japanese journal of pharmacology, 1986, Volume: 42, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Ethanol; Ethylm

1986
Protection by sucralfate against indomethacin induced gastric ulceration in the guinea pig.
    Pathology, 1985, Volume: 17, Issue:3

    Topics: Aluminum; Animals; Guinea Pigs; Indomethacin; Membrane Potentials; Permeability; Stomach Ulcer; Sucr

1985
[Influence of oleic acid on gastric mucus secretion in indomethacin-induced gastric mucosal lesions in rats].
    Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:6

    Topics: Animals; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Indomethacin; Male; Mucus; Oleic

1985
Cytoprotective effect of sofalcone in the rat gastric mucosa.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:1

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Carbenoxolone; Chalcone; Chalcones; Cimetidine; Di

1985
Fatal antral ulcer in conventionally fed W/Wv mutant mice given indomethacin by injection.
    The American journal of pathology, 1985, Volume: 119, Issue:3

    Topics: Animals; Aspirin; Dinoprostone; Disease Susceptibility; Fasting; Gastric Mucosa; Indomethacin; Injec

1985
Gastric mucosal protection by spizofurone.
    European journal of pharmacology, 1985, May-28, Volume: 112, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Dinoprostone; Electrolytes; Ethanol; Gastric Mucos

1985
Effects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosa.
    Digestion, 1985, Volume: 32, Issue:4

    Topics: Animals; Dinoprostone; Ethanol; Gastric Mucosa; Histamine; Indomethacin; Male; Prostaglandins E; Rat

1985
Ulcer formation and cytoprotection by acetazolamide.
    European journal of pharmacology, 1985, Dec-03, Volume: 118, Issue:3

    Topics: 16,16-Dimethylprostaglandin E2; Acetazolamide; Animals; Aspirin; Dinoprostone; Ethanol; Female; Gast

1985
Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103).
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:2

    Topics: Acetates; Acetic Acid; Aminopyrine; Animals; Anti-Ulcer Agents; Aspirin; Bethanechol Compounds; Cime

1985
Analysis of the analgesic and anti-inflammatory effects of rimazolium, a pyrido-pyrimidine derivative, compared with that of prostaglandin synthesis inhibitors and morphine.
    Drugs under experimental and clinical research, 1985, Volume: 11, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Indomethacin; Leukocytes; Luminescent Meas

1985
Possible involvement of non-steroidal anti-inflammatory drugs in vagal-mediated gastric acid secretion in rats.
    Japanese journal of pharmacology, 1985, Volume: 37, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Deoxyglucose; Dinoprostone; Gastric Acid; Histamine; Humans; Imme

1985
Salicylic acid blocks indomethacin-induced cyclooxygenase inhibition and lesion formation in rat gastric mucosa.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 178, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Gastric Mucosa; Humans; Indomethacin;

1985
[Effects of 2-benzyloxycarbonylphenyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride monohydrate (TKG01) and its clathrate compound with beta-cyclodextrin (TA903) on experimental gastric ulcers and gastric secretion in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 85, Issue:3

    Topics: Animals; Anti-Ulcer Agents; beta-Cyclodextrins; Cyclodextrins; Cyclohexanecarboxylic Acids; Dextrins

1985
Structural damage and changes in eicosanoid metabolites in the gastric mucosa of rats and pigs induced by anti-inflammatory drugs of varying ulcerogenicity.
    International journal of tissue reactions, 1986, Volume: 8, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Diflunisal; Gastric Mucosa; Indomethacin; Membrane Poten

1986
Comparison of inhibitory effects of atropine, cimetidine, and atropine plus cimetidine on the indomethacin-provoked gastric mucosal erosions in rats.
    International journal of tissue reactions, 1986, Volume: 8, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Synergism;

1986
Prolactin inhibits the development of stress-induced ulcers in the rat.
    Life sciences, 1985, Jan-14, Volume: 36, Issue:2

    Topics: Animals; Domperidone; Haloperidol; Indomethacin; Kidney; Male; Pituitary Gland, Anterior; Prolactin;

1985
Morphine potentiates the gastroulcerogenic effect of indometacin in rats.
    Pharmacology, 1985, Volume: 30, Issue:1

    Topics: Animals; Atropine; Cimetidine; Drug Synergism; Female; Gastric Mucosa; Indomethacin; Male; Morphine;

1985
Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat.
    Pharmacology, 1985, Volume: 30, Issue:1

    Topics: Animals; Body Weight; Eating; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Intestinal Disea

1985
Incidence of gastric ulcers by indomethacin and piroxicam in rats.
    Archives of toxicology, 1985, Volume: 56, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Female; Indomethacin; Male; Piroxicam; Rats; Rats, Inbred

1985
Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat.
    Acta physiologica Hungarica, 1985, Volume: 65, Issue:3

    Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Eating; Female; Indomethacin; Intestinal Disease

1985
Influence of antioxidants and radical scavengers on ethanol-induced gastric ulcers in the rat.
    General pharmacology, 1985, Volume: 16, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Benzoates; Benzoic Acid; Cimetidine; Ethanol; Free Radical

1985
Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms.
    Gut, 1985, Volume: 26, Issue:8

    Topics: Acetaminophen; Alcohol Drinking; Analgesics; Anti-Inflammatory Agents; Aspirin; Chronic Disease; Fem

1985
Experimental anti-ulcer activity of Veronica officinalis L. extracts.
    Journal of ethnopharmacology, 1985, Volume: 13, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Indomethacin; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbre

1985
Gastric antral ulcers induced by a combination of acid, indomethacin and ischemia in rats.
    Japanese journal of pharmacology, 1985, Volume: 38, Issue:2

    Topics: Animals; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Ischemia; Male; Pyloric Antrum; Rats; Rats

1985
Gastrointestinal effects of the extracts of Rhigiocarya racemifera (Menispermaceae).
    General pharmacology, 1985, Volume: 16, Issue:4

    Topics: Animals; Cimetidine; Female; Gastrointestinal Diseases; Glycosides; Indomethacin; Ligation; Male; Mi

1985
Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats.
    International journal of tissue reactions, 1985, Volume: 7, Issue:4

    Topics: Animals; Carrageenan; Edema; Female; Indomethacin; Lipid Peroxides; Rats; Stomach Ulcer; Time Factor

1985
Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:10

    Topics: Acetates; Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Chronic Dise

1985
Effects of intracerebroventricular bombesin on gastric ulcers and gastric glycoproteins in rats.
    Journal of pharmacobio-dynamics, 1985, Volume: 8, Issue:10

    Topics: Animals; Aspirin; Bombesin; Chromatography, Gel; Gastric Acid; Gastric Mucosa; Glycoproteins; Indome

1985
The effect of D-penicillamine in different experimental gastric ulcer models in the rat.
    Acta medica Hungarica, 1985, Volume: 42, Issue:3-4

    Topics: Animals; Dose-Response Relationship, Drug; Female; Indomethacin; Penicillamine; Rats; Rats, Inbred S

1985
[Gastroduodenal ulcer: pathogenetic and clinical aspects].
    Minerva medica, 1974, Sep-15, Volume: 65, Issue:64

    Topics: Alcoholic Beverages; Diet; Duodenal Ulcer; Gastric Juice; Gastrins; Gastrointestinal Hormones; Hista

1974
Pharmacology of zolimidine (2-(p-methylsulfonylphenyl)-imidazo (1,2-a) pyridine) a new non-anticholinergic gastroprotective agent. II) Protective activity against drug-induced experimental ulcers.
    Panminerva medica, 1974, Volume: 16, Issue:10

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Guinea Pigs; Histamine; Histamine H1 Antagon

1974
Pharmacology of zolimidine (2-(p-methylsulfonylphenyl)-imidazo (1,2-a) pyridine) a new non-anticholinergic gastroprotective agent. IV) Enhancement of gastric mucus production in different experimental models.
    Panminerva medica, 1974, Volume: 16, Issue:10

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cold Temperature; Gastric Mucins; Gastric Mu

1974
[Iatrogenic gastroduodenal ulcerations. Corticosteroids excluded].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1973, Nov-20, Volume: 49, Issue:47

    Topics: Aged; Bone Neoplasms; Carcinoma, Squamous Cell; Cyclophosphamide; Duodenal Ulcer; Female; Humans; In

1973
Anti-inflammatory drugs in rheumatic diseases.
    The Practitioner, 1974, Volume: 213, Issue:1276 SPEC

    Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Aspirin

1974
Evaluation of the potential of gastric ulceration after administration of certain drugs.
    Experimental and molecular pathology, 1967, Volume: 6, Issue:1

    Topics: Amines; Aminopyrine; Animals; Ascorbic Acid; Aspirin; Chlorpromazine; Cortisone; Desoxycorticosteron

1967
Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids.
    Prostaglandins, 1974, Aug-10, Volume: 7, Issue:3

    Topics: Administration, Oral; Animals; Depression, Chemical; Diarrhea; Fatty Acids, Unsaturated; Female; Gas

1974
Prostaglandins VII: a proposed role for Pge2 in the genesis of stress-induced gastric ulcers.
    Prostaglandins, 1974, Oct-10, Volume: 8, Issue:1

    Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Indomethacin; Injections, Subcutane

1974
Species differences in susceptibility to the gastro-ulcerogenic action of anti-inflammatory agents.
    Pharmacology, 1974, Volume: 11, Issue:4

    Topics: Administration, Oral; Ambystoma; Animals; Anti-Inflammatory Agents; Cricetinae; Dose-Response Relati

1974
Prevention by two anticholinergic drugs of indomethacin-induced gastric mucosal ulceration in rats.
    Israel journal of medical sciences, 1974, Volume: 10, Issue:11

    Topics: Animals; Atropine; Female; Gastric Mucosa; Humans; Indomethacin; Male; Rats; Stomach Ulcer

1974
Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.
    European journal of pharmacology, 1973, Volume: 22, Issue:2

    Topics: Adrenal Glands; Adrenalectomy; Animals; Atropine; Cordotomy; Dose-Response Relationship, Drug; Femal

1973
Gastric mucosal damage by anti-inflammatory drugs.
    Rheumatology and physical medicine, 1972, Volume: 11, Issue:8

    Topics: Absorption; Anti-Inflammatory Agents; Aspirin; Diffusion; Gastric Mucins; Gastric Mucosa; Gastritis;

1972
Effects of the non-steroidal antiphlogistics on the gastric mucosal barrier and hexosamine content in rats.
    Japanese journal of pharmacology, 1972, Volume: 22, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biological Transport; Carboxylic Acids; Chlorine; Cycloh

1972
[Ulcers of the gastroduodenal tract due to drugs. Apropos of a personal experience].
    Acta gastro-enterologica Belgica, 1972, Volume: 35, Issue:9

    Topics: Adrenal Cortex Hormones; Adult; Aged; Analgesics; Aspirin; Duodenal Ulcer; Female; Gastrointestinal

1972
[Gastro-duodenal tolerance of some drugs with analgesic effect. Clinico-endoscopic considerations].
    Minerva medica, 1974, Feb-24, Volume: 65, Issue:14

    Topics: Analgesics; Anti-Inflammatory Agents; Antimalarials; Aspirin; Digestive System; Duodenal Ulcer; Esop

1974
Pharmacology of a new non-steroidal anti-inflammatory agent 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one (W-2395).
    European journal of pharmacology, 1974, Volume: 26, Issue:1

    Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Benzoxazi

1974
Effect of L-glutamine on indomethacin-induced gastric lesions in the rat.
    Japanese journal of pharmacology, 1974, Volume: 24, Issue:1

    Topics: Animals; Glutamine; Indomethacin; Ligation; Male; Pylorus; Rats; Stomach Ulcer

1974
Renal and gastric lesions after phenylbutazone and indomethacin in the rat.
    Pathology, 1974, Volume: 6, Issue:4

    Topics: Animals; Ascites; Epithelium; Female; Gastrointestinal Hemorrhage; Indomethacin; Kidney; Kidney Papi

1974
[Gastric erosions and ulcerations in gastritis caused by drugs].
    Zeitschrift fur Gastroenterologie, 1972, Volume: 10, Issue:8

    Topics: Aminopyrine; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastritis; Gastroscopy; Gluco

1972
The Berry Lecture. Studies of the gastric mucosal barrier--its relevance to clinical gastric disease.
    Guy's Hospital reports, 1972, Volume: 121, Issue:4

    Topics: Animals; Aspirin; Dogs; Epithelium; Female; Gastric Mucins; Gastric Mucosa; Gastritis; Humans; Hydro

1972
Prevention by disulfiram of restraint- and indomethacin-induced gastric mucosal ulceration in rats.
    Israel journal of medical sciences, 1973, Volume: 9, Issue:5

    Topics: Animals; Cold Temperature; Disulfiram; Fasting; Female; Gastric Mucosa; Immobilization; Indomethacin

1973
Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis.
    British medical journal, 1974, Jan-05, Volume: 1, Issue:5896

    Topics: Adult; Arthritis, Rheumatoid; Aspirin; Biological Transport, Active; Cell Membrane Permeability; Chl

1974
[Significance of the gastric mucus as a mucosa-protection].
    Fortschritte der Medizin, 1974, Jan-17, Volume: 92, Issue:2

    Topics: Cortisone; Gastric Juice; Gastric Mucosa; Glycoproteins; Humans; Indomethacin; Phenylbutazone; Stoma

1974
Upper gastrointestinal disease in rheumatoid arthritis.
    The American journal of digestive diseases, 1974, Volume: 19, Issue:5

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Arizona; Arthritis, Rheumatoid; Aspir

1974
Prevention of restraint and indomethacin-induced gastric ulceration by bile duct or pylorus ligation in rats.
    Digestion, 1974, Volume: 10, Issue:2

    Topics: Animals; Bile Acids and Salts; Bile Ducts; Disease Models, Animal; Female; Indomethacin; Ligation; M

1974
[Blood levels and urinary excretion of zolimidine-indomethacin combination].
    Bollettino chimico farmaceutico, 1974, Volume: 113, Issue:2

    Topics: Animals; Drug Combinations; Female; Imidazoles; Indomethacin; Male; Pyridines; Rats; Stomach Ulcer

1974
Multiple benign gastric ulcers. A clinical and gastroscopic study.
    The American journal of gastroenterology, 1974, Volume: 62, Issue:1

    Topics: Adult; Aged; Alcohol Drinking; Gastroscopy; Humans; Indomethacin; Male; Middle Aged; Peptic Ulcer He

1974
Gastric blood flow and its distribution during indomethacin administration.
    Surgery, gynecology & obstetrics, 1970, Volume: 130, Issue:5

    Topics: Animals; Catheterization; Dogs; Duodenum; Esophagus; Indomethacin; Melena; Radioisotope Dilution Tec

1970
The effects of anti-ulcer agents on indomethacin-induced gastric ulceration in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 192, Issue:2

    Topics: Analysis of Variance; Animals; Antacids; Drug Antagonism; Gastric Juice; Gastric Mucosa; Indomethaci

1971
[Comparative study on the ulcerogenous effect of various antiphlogistic agents].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Female; Gastric Mucosa; Indomethacin; Prednisone; Rats;

1971
The production of acute gastric ulceration by indomethacin in the rat.
    Scandinavian journal of gastroenterology, 1969, Volume: 4, Issue:3

    Topics: Animals; Indomethacin; Injections, Intraperitoneal; Male; Methods; Rats; Stomach Ulcer; Time Factors

1969
Gastric ulcer and the anti-arthritic drugs.
    Postgraduate medical journal, 1971, Volume: 47, Issue:546

    Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Indomethacin; Male; Middle Aged; Peptic Ulcer He

1971
Indomethacin. Effect on gastric secretion, parietal cell population, and ulcer provocation in the dog.
    Archives of surgery (Chicago, Ill. : 1960), 1968, Volume: 97, Issue:5

    Topics: Animals; Dogs; Gastric Juice; Gastric Mucosa; Indomethacin; Peptic Ulcer Hemorrhage; Peptic Ulcer Pe

1968
Gastric ulceration occurring during indomethacin therapy.
    British medical journal, 1968, Dec-21, Volume: 4, Issue:5633

    Topics: Adult; Aged; Anemia; Dyspepsia; Female; Humans; Indomethacin; Male; Middle Aged; Pylorus; Radiograph

1968
[Use of antiphlogistics for athletic injuries].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1969, Jun-15, Volume: 89, Issue:12

    Topics: Analgesics; Athletic Injuries; Central Nervous System Diseases; Humans; Indomethacin; Male; Oxyphenb

1969
[Pharmacological and toxicological testing of new anti-inflammatory agent azapropazon=3-dimethylamine-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:1

    Topics: Abnormalities, Drug-Induced; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bloo

1969
Indomethacin and gastric ulcer.
    British medical journal, 1965, Oct-23, Volume: 2, Issue:5468

    Topics: Humans; Indomethacin; Stomach Ulcer

1965
[Efficacy of indomethacin treatment].
    Ugeskrift for laeger, 1965, Sep-09, Volume: 127, Issue:36

    Topics: Aged; Female; Humans; Indomethacin; Stomach Ulcer

1965