Page last updated: 2024-10-29

indomethacin and Stevens-Johnson Syndrome

indomethacin has been researched along with Stevens-Johnson Syndrome in 7 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

ExcerptRelevanceReference
"A middle-aged female with rheumatoid arthritis was commenced on indomethacin."3.66A case of toxic epidermal necrolysis secondary to indomethacin. ( Hanly, JG; Molloy, M; O'Sullivan, M, 1983)
"Since toxic epidermal necrolysis is a potentially fatal disease, awareness of a possible association is warranted."1.30Toxic epidermal necrolysis associated with treatment for preterm labor. ( Claessens, N; Delbeke, L; Lafaire, C; Lambert, J; Matthieu, L; Van Marck, E, 1998)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19904 (57.14)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Iijima, M1
O'Sullivan, M1
Hanly, JG1
Molloy, M1
Chircu, LV1
Monacelli, M1
Traditi, F1
Piccoli, M1
Lacava, V1
Finamore, B1
Rossi, F1
Lear, JT1
English, JS1
Claessens, N1
Delbeke, L1
Lambert, J1
Matthieu, L1
Lafaire, C1
Van Marck, E1
Bigby, M1
Stern, R1
Bruinsma, W1

Reviews

2 reviews available for indomethacin and Stevens-Johnson Syndrome

ArticleYear
[Judicial judgment for severe adverse drug reaction (ADR)].
    Arerugi = [Allergy], 2007, Volume: 56, Issue:11

    Topics: Clinical Competence; Humans; Indomethacin; Liability, Legal; Malpractice; Phenobarbital; Referral an

2007
Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:5 Pt 1

    Topics: Acetates; Anti-Inflammatory Agents; Aspirin; Drug Eruptions; Humans; Ibuprofen; Indomethacin; ortho-

1985

Other Studies

5 other studies available for indomethacin and Stevens-Johnson Syndrome

ArticleYear
A case of toxic epidermal necrolysis secondary to indomethacin.
    British journal of rheumatology, 1983, Volume: 22, Issue:1

    Topics: Arthritis, Rheumatoid; Female; Humans; Indomethacin; Middle Aged; Stevens-Johnson Syndrome

1983
[Clinico-therapeutic considerations on 7 cases of Lyell's syndrome].
    La Clinica terapeutica, 1980, Jun-30, Volume: 93, Issue:6

    Topics: Adolescent; Adult; Aminopyrine; Cephalosporins; Child; Female; Glucocorticoids; Hair Dyes; Humans; I

1980
Toxic epidermal necrolysis associated with indomethacin therapy.
    Postgraduate medical journal, 1996, Volume: 72, Issue:845

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Male; Middle Aged; Stevens-Johnson Sy

1996
Toxic epidermal necrolysis associated with treatment for preterm labor.
    Dermatology (Basel, Switzerland), 1998, Volume: 196, Issue:4

    Topics: Adult; Betamethasone; Female; Gestational Age; Glucocorticoids; Humans; Indomethacin; Obstetric Labo

1998
Adverse reaction profiles of drug eruptions.
    Dermatologica, 1972, Volume: 145, Issue:6

    Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Er

1972