indomethacin has been researched along with Stevens-Johnson Syndrome in 7 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A middle-aged female with rheumatoid arthritis was commenced on indomethacin." | 3.66 | A case of toxic epidermal necrolysis secondary to indomethacin. ( Hanly, JG; Molloy, M; O'Sullivan, M, 1983) |
| "Since toxic epidermal necrolysis is a potentially fatal disease, awareness of a possible association is warranted." | 1.30 | Toxic epidermal necrolysis associated with treatment for preterm labor. ( Claessens, N; Delbeke, L; Lafaire, C; Lambert, J; Matthieu, L; Van Marck, E, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iijima, M | 1 |
| O'Sullivan, M | 1 |
| Hanly, JG | 1 |
| Molloy, M | 1 |
| Chircu, LV | 1 |
| Monacelli, M | 1 |
| Traditi, F | 1 |
| Piccoli, M | 1 |
| Lacava, V | 1 |
| Finamore, B | 1 |
| Rossi, F | 1 |
| Lear, JT | 1 |
| English, JS | 1 |
| Claessens, N | 1 |
| Delbeke, L | 1 |
| Lambert, J | 1 |
| Matthieu, L | 1 |
| Lafaire, C | 1 |
| Van Marck, E | 1 |
| Bigby, M | 1 |
| Stern, R | 1 |
| Bruinsma, W | 1 |
2 reviews available for indomethacin and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
[Judicial judgment for severe adverse drug reaction (ADR)].
Topics: Clinical Competence; Humans; Indomethacin; Liability, Legal; Malpractice; Phenobarbital; Referral an | 2007 |
Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
Topics: Acetates; Anti-Inflammatory Agents; Aspirin; Drug Eruptions; Humans; Ibuprofen; Indomethacin; ortho- | 1985 |
5 other studies available for indomethacin and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
A case of toxic epidermal necrolysis secondary to indomethacin.
Topics: Arthritis, Rheumatoid; Female; Humans; Indomethacin; Middle Aged; Stevens-Johnson Syndrome | 1983 |
[Clinico-therapeutic considerations on 7 cases of Lyell's syndrome].
Topics: Adolescent; Adult; Aminopyrine; Cephalosporins; Child; Female; Glucocorticoids; Hair Dyes; Humans; I | 1980 |
Toxic epidermal necrolysis associated with indomethacin therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Male; Middle Aged; Stevens-Johnson Sy | 1996 |
Toxic epidermal necrolysis associated with treatment for preterm labor.
Topics: Adult; Betamethasone; Female; Gestational Age; Glucocorticoids; Humans; Indomethacin; Obstetric Labo | 1998 |
Adverse reaction profiles of drug eruptions.
Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Er | 1972 |