indomethacin has been researched along with Spinal Cord Injuries in 31 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The potential efficacy of indomethacin (a potent inhibitor of endogenous prostaglandin synthesis) on spinal cord-evoked potentials and edema formation occurring after a focal trauma to the spinal cord was examined in a rat model." | 7.68 | Indomethacin, an inhibitor of prostaglandin synthesis attenuates alteration in spinal cord evoked potentials and edema formation after trauma to the spinal cord: an experimental study in the rat. ( Olsson, Y; Sharma, HS; Stålberg, E; Winkler, T, 1993) |
| " Pretreatment with p-chlorophenylalanine, indomethacin, ibuprofen, and nimodipine attenuated the SCEP changes immediately after trauma and resulted in a marked reduction in edema formation, BSCB permeability, and blood flow changes at 5 h." | 3.71 | Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. ( Sharma, HS; Winkler, T, 2002) |
| "The potential efficacy of indomethacin (a potent inhibitor of endogenous prostaglandin synthesis) on spinal cord-evoked potentials and edema formation occurring after a focal trauma to the spinal cord was examined in a rat model." | 3.68 | Indomethacin, an inhibitor of prostaglandin synthesis attenuates alteration in spinal cord evoked potentials and edema formation after trauma to the spinal cord: an experimental study in the rat. ( Olsson, Y; Sharma, HS; Stålberg, E; Winkler, T, 1993) |
| "Heterotopic ossification is a frequent complication after spinal cord injury." | 1.39 | Ankylosing pelvitrochanteric heterotopic ossification in a patient with spinal cord injury. ( Gurcan, S; Kose, O; Ozyurek, S; Sehirlioglu, A, 2013) |
| " For these studies, animals were dosed with CP-154,526 (3, 10, 30 mg/kg) and NBI 27914 (1-30 mg/kg) 1 h prior to the assessment of tactile, thermal or mechanical hypersensitivity, respectively." | 1.36 | Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. ( Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT, 2010) |
| " In the present report, we have analyzed the effect of the central nervous system (CNS) permissive, putatively neuroprotective, anti-inflammatory cyclooxygenase-1/-2 (COX-1/-2) inhibitor indomethacin in CNS effective dosage (2 mg/kg/day) on lesional RhoA expression following subacute spinal cord injury." | 1.32 | Lesional RhoA+ cell numbers are suppressed by anti-inflammatory, cyclooxygenase-inhibiting treatment following subacute spinal cord injury. ( Conrad, S; Elbert, T; Meyermann, R; Schluesener, HJ; Schwab, JM; Trautmann, K, 2004) |
| "Indomethacin was shown to be efficacious in holding back or slowing down the HO evolution." | 1.30 | Prostaglandin E2 measurements: their value in the early diagnosis of heterotopic ossification in spinal cord injury patients. ( Capaul, M; Rossier, AB; Schurch, B; Vallotton, MB, 1997) |
| "Prolonged fever is an uncommon diagnostic problem in a spinal cord injury patient." | 1.29 | Prolonged fever and heterotopic ossification in a C4 tetraplegic patient. Case report. ( Kong, KH; Tow, AP, 1995) |
| "Whereas the articular complications of heterotopic ossification have been well documented, the vascular complications are less well known." | 1.29 | [Heterotopic ossification and vascular compression]. ( Brissot, R; Gallien, P; Le Bot, MP; Nicolas, B; Rivier, I; Robineau, S; Sarkis, S, 1994) |
| "Pretreatment with indomethacin (10 mg/kg, i." | 1.29 | Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat. ( Dey, PK; Nyberg, F; Olsson, Y; Sharma, HS, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.68) | 18.7374 |
| 1990's | 17 (54.84) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gurcan, S | 1 |
| Ozyurek, S | 1 |
| Kose, O | 1 |
| Sehirlioglu, A | 1 |
| Hummel, M | 1 |
| Cummons, T | 1 |
| Lu, P | 1 |
| Mark, L | 1 |
| Harrison, JE | 1 |
| Kennedy, JD | 1 |
| Whiteside, GT | 1 |
| Xing, B | 1 |
| Li, H | 1 |
| Wang, H | 1 |
| Mukhopadhyay, D | 1 |
| Fisher, D | 1 |
| Gilpin, CJ | 1 |
| Li, S | 1 |
| Guth, L | 3 |
| Popovich, PG | 1 |
| Tovar, CA | 1 |
| Wei, P | 1 |
| Fisher, L | 1 |
| Jakeman, LB | 1 |
| Basso, DM | 1 |
| Sharma, HS | 6 |
| Winkler, T | 3 |
| Schwab, JM | 1 |
| Conrad, S | 1 |
| Elbert, T | 1 |
| Trautmann, K | 1 |
| Meyermann, R | 1 |
| Schluesener, HJ | 1 |
| Pantović, R | 1 |
| Draganić, P | 1 |
| Eraković, V | 1 |
| Blagović, B | 1 |
| Milin, C | 1 |
| Simonić, A | 1 |
| Kitamura, T | 1 |
| Harada, N | 2 |
| Goto, E | 1 |
| Tanaka, K | 1 |
| Arai, M | 1 |
| Shimada, S | 1 |
| Okajima, K | 2 |
| Taoka, Y | 1 |
| Hallenbeck, JM | 1 |
| Jacobs, TP | 1 |
| Faden, AI | 1 |
| Tow, AP | 1 |
| Kong, KH | 1 |
| Gallien, P | 1 |
| Nicolas, B | 1 |
| Le Bot, MP | 1 |
| Robineau, S | 1 |
| Rivier, I | 1 |
| Sarkis, S | 1 |
| Brissot, R | 1 |
| Mitsuhashi, T | 1 |
| Ikata, T | 1 |
| Morimoto, K | 1 |
| Tonai, T | 1 |
| Katoh, S | 1 |
| Zhang, Z | 2 |
| Roberts, E | 1 |
| Olsson, Y | 4 |
| Nyberg, F | 1 |
| Dey, PK | 1 |
| DiProspero, NA | 1 |
| Joubin, K | 1 |
| Fitch, MT | 1 |
| Biering-Sørensen, F | 1 |
| Tøndevold, E | 1 |
| Cervós-Navarro, J | 2 |
| Stålberg, E | 1 |
| Lefkoe, TP | 1 |
| Cardenas, DD | 1 |
| Schurch, B | 1 |
| Capaul, M | 1 |
| Vallotton, MB | 1 |
| Rossier, AB | 1 |
| Westman, J | 1 |
| Leanza, G | 1 |
| Cataudella, T | 1 |
| Dimauro, R | 1 |
| Monaco, S | 1 |
| Stanzani, S | 1 |
| Guven, MB | 1 |
| Cirak, B | 1 |
| Yuceer, N | 1 |
| Ozveren, F | 1 |
| Banovac, K | 1 |
| Williams, JM | 1 |
| Patrick, LD | 1 |
| Haniff, YM | 1 |
| Jonsson, HT | 1 |
| Daniell, HB | 1 |
| Pettersson, A | 1 |
| Simpson, RK | 1 |
| Baskin, DS | 1 |
| Dudley, AW | 1 |
| Bogue, L | 1 |
| Rothenberg, F | 1 |
| Delattre, JY | 1 |
| Rosenblum, MK | 1 |
| Thaler, HT | 1 |
| Mandell, L | 1 |
| Shapiro, WR | 1 |
| Posner, JB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of Spinal Radiosurgery[NCT00573872] | 43 participants (Actual) | Interventional | 2005-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CTCAE version 3. Acute toxicity will be recorded if toxicity occurs early phase or within 3 months, and late toxicity would be any toxicity that follows those 3 months. (NCT00573872)
Timeframe: 2 years
| Intervention | events (Number) |
|---|---|
| Spinal Radiosurgery | 4 |
Lack of tumor growth by CT or MRI at last follow-up (NCT00573872)
Timeframe: 2 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Spinal Radiosurgery | 21 |
"Physician's subjective report of palliative pain relief. The maximal benefit patient received (best response) is reported. Scale is pain described as worse, stable, better, or completely resolved. In the reporting better or completely resolved indicates response to treatment." (NCT00573872)
Timeframe: 2 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Spinal Radiosurgery | 29 |
1 trial available for indomethacin and Spinal Cord Injuries
| Article | Year |
|---|---|
Prevention of heterotopic ossification after spinal cord injury with indomethacin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Double-Blind Method; Humans | 2001 |
30 other studies available for indomethacin and Spinal Cord Injuries
| Article | Year |
|---|---|
Ankylosing pelvitrochanteric heterotopic ossification in a patient with spinal cord injury.
Topics: Adult; Ankylosis; Anti-Inflammatory Agents, Non-Steroidal; Female; Hip Joint; Humans; Indomethacin; | 2013 |
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Rele | 2010 |
RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Axons; Cells, Cultured; Female; Ibuprofen; Indomet | 2011 |
A reassessment of LPS/indomethacin/pregnenolone combination therapy after spinal cord injury in rats.
Topics: Animals; Female; Indomethacin; Lipopolysaccharides; Neuroprotective Agents; Pregnenolone; Spinal Cor | 2012 |
A reassessment of a classic neuroprotective combination therapy for spinal cord injured rats: LPS/pregnenolone/indomethacin.
Topics: Animals; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Indomethacin; Lipopolysacc | 2012 |
Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Anti-I | 2002 |
Lesional RhoA+ cell numbers are suppressed by anti-inflammatory, cyclooxygenase-inhibiting treatment following subacute spinal cord injury.
Topics: Acute Disease; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen | 2004 |
Effect of indomethacin on motor activity and spinal cord free fatty acid content after experimental spinal cord injury in rabbits.
Topics: Animals; Disease Models, Animal; Fatty Acids, Nonesterified; Indomethacin; Motor Activity; Paraplegi | 2005 |
Activation of sensory neurons contributes to reduce spinal cord injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Anilides; Animals; Calcitonin Gene-Related Peptide; Cinnamates; Cycloo | 2007 |
Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Epoprostenol; Iloprost; Indomethacin; Male; Motor Activity; Neut | 2006 |
Combined PGI2, indomethacin, and heparin improves neurological recovery after spinal trauma in cats.
Topics: Animals; Cats; Drug Therapy, Combination; Epoprostenol; Heparin; Indomethacin; Naloxone; Nervous Sys | 1983 |
Prolonged fever and heterotopic ossification in a C4 tetraplegic patient. Case report.
Topics: Adult; Fever; Hip; Humans; Indomethacin; Leukocyte Count; Magnetic Resonance Imaging; Male; Ossifica | 1995 |
[Heterotopic ossification and vascular compression].
Topics: Adult; Craniocerebral Trauma; Etidronic Acid; Femoral Vein; Humans; Indomethacin; Male; Middle Aged; | 1994 |
Possibilities to evaluate and diminish the effects of the trauma in spinal cord lesions. An experimental study in the rat.
Topics: Animals; Disease Models, Animal; Evoked Potentials; Indomethacin; Naloxone; Neural Conduction; Nimod | 1994 |
Increased production of eicosanoids, TXA2, PGI2 and LTC4 in experimental spinal cord injuries.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Epoprostenol; Flavonoids; Fluoresceins; Guinea Pigs; Indometh | 1994 |
Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury.
Topics: Analysis of Variance; Animals; Aspirin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Doub | 1994 |
Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Capillary Permeability; Edema; Indomethacin | 1993 |
Spinal cord injury in the rat: treatment with bacterial lipopolysaccharide and indomethacin enhances cellular repair and locomotor function.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Indomethacin; Lipopolysaccharide | 1994 |
Indomethacin and disodium etidronate for the prevention of recurrence of heterotopic ossification after surgical resection. Two case reports.
Topics: Adolescent; Adult; Etidronic Acid; Hip; Humans; Indomethacin; Male; Ossification, Heterotopic; Recur | 1993 |
Early perifocal cell changes and edema in traumatic injury of the spinal cord are reduced by indomethacin, an inhibitor of prostaglandin synthesis. Experimental study in the rat.
Topics: Animals; Body Water; Edema; Immunoenzyme Techniques; Indomethacin; Male; Microscopy, Electron; Rats; | 1993 |
Indomethacin, an inhibitor of prostaglandin synthesis attenuates alteration in spinal cord evoked potentials and edema formation after trauma to the spinal cord: an experimental study in the rat.
Topics: Analysis of Variance; Animals; Edema; Evoked Potentials; Indomethacin; Laminectomy; Male; Rats; Rats | 1993 |
Reflex sympathetic dystrophy of the lower extremity in tetraplegia: case report.
Topics: Adrenergic alpha-Antagonists; Adult; Humans; Indomethacin; Leg; Male; Ossification, Heterotopic; Phe | 1996 |
Prostaglandin E2 measurements: their value in the early diagnosis of heterotopic ossification in spinal cord injury patients.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemotherapy, Adjuvant; Dinoprostone; | 1997 |
Prostaglandins modulate constitutive isoform of heat shock protein (72 kD) response following trauma to the rat spinal cord.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Heat-Shock Proteins; HSP72 Heat-Shock Pr | 1997 |
Release properties and functional integration of noradrenergic-rich tissue grafted to the denervated spinal cord of the adult rat.
Topics: Age Factors; Animals; Behavior, Animal; Brain Tissue Transplantation; Dopamine beta-Hydroxylase; Fem | 1999 |
Is indomethacin harmful in spinal cord injury treatment? An experimental study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Indomethacin; Injections, Intraperitoneal; | 1999 |
Altered levels of PGF in cat spinal cord tissue following traumatic injury.
Topics: Animals; Cats; Indomethacin; Prostaglandins E; Spinal Cord; Spinal Cord Injuries | 1976 |
Release of endogenous neurochemicals may increase vascular permeability, induce edema and influence cell changes in trauma to the spinal cord.
Topics: Animals; Blood Pressure; Body Water; Brain Edema; Capillary Permeability; Carbon Dioxide; Fenclonine | 1992 |
The influence of long-term nifedipine or indomethacin therapy on neurologic recovery from experimental spinal cord injury.
Topics: Animals; Evoked Potentials; Evoked Potentials, Somatosensory; Indomethacin; Nifedipine; Prostaglandi | 1991 |
A model of radiation myelopathy in the rat. Pathology, regional capillary permeability changes and treatment with dexamethasone.
Topics: Angiography; Animals; Autoradiography; Capillary Permeability; Dexamethasone; Indomethacin; Male; Pa | 1988 |