Page last updated: 2024-10-29

indomethacin and Sleep Apnea, Obstructive

indomethacin has been researched along with Sleep Apnea, Obstructive in 5 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)

Research Excerpts

ExcerptRelevanceReference
"Patients with obstructive sleep apnea (OSA) are predisposed to instability in central ventilatory control during sleep."1.36Exacerbation of obstructive sleep apnea by oral indomethacin. ( Ainslie, P; Burgess, KR; Dawson, A; Fan, JL; Lucas, R; Lucas, S; Peebles, K; Shepherd, K; Swart, M; Thomas, K, 2010)
"A hypnic headache was captured in one patient arising out of rapid eye movement sleep at a time of severe oxygen desaturation."1.31Polysomnography in hypnic headache syndrome. ( Dodick, DW, 2000)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beaudin, AE2
Pun, M2
Yang, C1
Nicholl, DD1
Steinback, CD1
Slater, DM1
Wynne-Edwards, KE2
Hanly, PJ2
Ahmed, SB2
Poulin, MJ2
Waltz, X1
Anderson, TJ1
Ivancev, V1
Bakovic, D1
Obad, A1
Breskovic, T1
Palada, I1
Joyner, MJ1
Dujic, Z1
Burgess, KR1
Fan, JL1
Peebles, K1
Thomas, K1
Lucas, S1
Lucas, R1
Dawson, A1
Swart, M1
Shepherd, K1
Ainslie, P1
Dodick, DW1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans[NCT01280006]Phase 1/Phase 212 participants (Actual)Interventional2011-01-31Completed
Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans[NCT02653638]Early Phase 180 participants (Actual)Interventional2016-06-30Completed
Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex[NCT02840851]46 participants (Actual)Observational2016-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for indomethacin and Sleep Apnea, Obstructive

ArticleYear
Cyclooxygenases 1 and 2 differentially regulate blood pressure and cerebrovascular responses to acute and chronic intermittent hypoxia: implications for sleep apnea.
    Journal of the American Heart Association, 2014, May-09, Volume: 3, Issue:3

    Topics: Adult; Blood Pressure; Celecoxib; Cerebrovascular Circulation; Cross-Over Studies; Cyclooxygenase 1;

2014
Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation.
    The European respiratory journal, 2015, Volume: 46, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Over Studies; Double-Blind Method;

2015
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
    Respiratory physiology & neurobiology, 2009, May-15, Volume: 166, Issue:3

    Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros

2009
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
    Respiratory physiology & neurobiology, 2009, May-15, Volume: 166, Issue:3

    Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros

2009
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
    Respiratory physiology & neurobiology, 2009, May-15, Volume: 166, Issue:3

    Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros

2009
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
    Respiratory physiology & neurobiology, 2009, May-15, Volume: 166, Issue:3

    Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros

2009

Other Studies

2 other studies available for indomethacin and Sleep Apnea, Obstructive

ArticleYear
Exacerbation of obstructive sleep apnea by oral indomethacin.
    Chest, 2010, Volume: 137, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebrovascular Circulation; Dose-Response Relationship, Dr

2010
Polysomnography in hypnic headache syndrome.
    Headache, 2000, Volume: 40, Issue:9

    Topics: Aged; Female; Headache; Humans; Indomethacin; Male; Melatonin; Middle Aged; Polysomnography; Recurre

2000