indomethacin has been researched along with Sleep Apnea, Obstructive in 5 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with obstructive sleep apnea (OSA) are predisposed to instability in central ventilatory control during sleep." | 1.36 | Exacerbation of obstructive sleep apnea by oral indomethacin. ( Ainslie, P; Burgess, KR; Dawson, A; Fan, JL; Lucas, R; Lucas, S; Peebles, K; Shepherd, K; Swart, M; Thomas, K, 2010) |
| "A hypnic headache was captured in one patient arising out of rapid eye movement sleep at a time of severe oxygen desaturation." | 1.31 | Polysomnography in hypnic headache syndrome. ( Dodick, DW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beaudin, AE | 2 |
| Pun, M | 2 |
| Yang, C | 1 |
| Nicholl, DD | 1 |
| Steinback, CD | 1 |
| Slater, DM | 1 |
| Wynne-Edwards, KE | 2 |
| Hanly, PJ | 2 |
| Ahmed, SB | 2 |
| Poulin, MJ | 2 |
| Waltz, X | 1 |
| Anderson, TJ | 1 |
| Ivancev, V | 1 |
| Bakovic, D | 1 |
| Obad, A | 1 |
| Breskovic, T | 1 |
| Palada, I | 1 |
| Joyner, MJ | 1 |
| Dujic, Z | 1 |
| Burgess, KR | 1 |
| Fan, JL | 1 |
| Peebles, K | 1 |
| Thomas, K | 1 |
| Lucas, S | 1 |
| Lucas, R | 1 |
| Dawson, A | 1 |
| Swart, M | 1 |
| Shepherd, K | 1 |
| Ainslie, P | 1 |
| Dodick, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans[NCT01280006] | Phase 1/Phase 2 | 12 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans[NCT02653638] | Early Phase 1 | 80 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex[NCT02840851] | 46 participants (Actual) | Observational | 2016-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for indomethacin and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Cyclooxygenases 1 and 2 differentially regulate blood pressure and cerebrovascular responses to acute and chronic intermittent hypoxia: implications for sleep apnea.
Topics: Adult; Blood Pressure; Celecoxib; Cerebrovascular Circulation; Cross-Over Studies; Cyclooxygenase 1; | 2014 |
Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Over Studies; Double-Blind Method; | 2015 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
2 other studies available for indomethacin and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Exacerbation of obstructive sleep apnea by oral indomethacin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebrovascular Circulation; Dose-Response Relationship, Dr | 2010 |
Polysomnography in hypnic headache syndrome.
Topics: Aged; Female; Headache; Humans; Indomethacin; Male; Melatonin; Middle Aged; Polysomnography; Recurre | 2000 |