indomethacin has been researched along with Sjogren's Syndrome in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "NK lymphocytosis is rarely associated with autoimmune disease, but the combination of indomethacin and steroid therapy may have a favorable effect for such patients." | 5.34 | Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil. ( Fujii, T; Fujita, Y; Mimori, T; Takeda, N; Tanaka, M, 2007) |
| "NK lymphocytosis is rarely associated with autoimmune disease, but the combination of indomethacin and steroid therapy may have a favorable effect for such patients." | 1.34 | Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil. ( Fujii, T; Fujita, Y; Mimori, T; Takeda, N; Tanaka, M, 2007) |
| "In most cases, Sweet's syndrome may occur in the absence of other diseases." | 1.34 | [Sweet's syndrome: a propos of 8 cases]. ( Ayed, MB; Benmously, R; Debbiche, A; Fenniche, S; Marrek, H; Mokhtar, I; Souissi, A; Zarrouk, M, 2007) |
| "Sjogren's syndrome and ankylosing spondylitis can occur either alone or in conjunction with other disorders." | 1.33 | Coexisting ankylosing spondylitis and Sjogren's syndrome: a case report. ( Cakirbay, H; Capkin, E; Guler, M; Karkucak, M; Topbas, M; Tosun, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aragona, P | 1 |
| Stilo, A | 1 |
| Ferreri, F | 1 |
| Mobrici, M | 1 |
| Tosun, M | 1 |
| Karkucak, M | 1 |
| Capkin, E | 1 |
| Cakirbay, H | 1 |
| Guler, M | 1 |
| Topbas, M | 1 |
| Roca, V | 1 |
| Larocca, L | 1 |
| Calafat, M | 1 |
| Aisemberg, J | 1 |
| Meiss, R | 1 |
| Franchi, AM | 1 |
| Leirós, CP | 1 |
| Fujita, Y | 1 |
| Fujii, T | 1 |
| Takeda, N | 1 |
| Tanaka, M | 1 |
| Mimori, T | 1 |
| Souissi, A | 1 |
| Benmously, R | 1 |
| Fenniche, S | 1 |
| Zarrouk, M | 1 |
| Marrek, H | 1 |
| Debbiche, A | 1 |
| Ayed, MB | 1 |
| Mokhtar, I | 1 |
| Miyasaka, N | 2 |
| Seaman, W | 1 |
| Bakshi, A | 1 |
| Sauvezie, B | 1 |
| Strand, V | 1 |
| Pope, R | 1 |
| Talal, N | 1 |
| McKendry, RJ | 1 |
| Virella, G | 1 |
| Espinoza, A | 1 |
| Patrick, H | 1 |
| Colwell, JA | 1 |
| Pedersen, BK | 1 |
| Oxholm, P | 1 |
| Manthorpe, R | 1 |
| Andersen, V | 1 |
| Murota, N | 1 |
| Yamaoka, K | 1 |
| Sato, K | 1 |
| Yamada, T | 1 |
| Nishido, T | 1 |
| Okuda, M | 1 |
| Henkind, P | 1 |
| Gold, DH | 1 |
1 review available for indomethacin and Sjogren's Syndrome
| Article | Year |
|---|---|
Ocular manifestations of rheumatic disorders. Natural and iatrogenic.
Topics: Adrenal Cortex Hormones; Arteritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Chloroquine; Conjunc | 1973 |
1 trial available for indomethacin and Sjogren's Syndrome
| Article | Year |
|---|---|
Effects of the topical treatment with NSAIDs on corneal sensitivity and ocular surface of Sjögren's syndrome patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cornea; Diclofenac; Dry Eye Syndromes; Epithel | 2005 |
9 other studies available for indomethacin and Sjogren's Syndrome
| Article | Year |
|---|---|
Coexisting ankylosing spondylitis and Sjogren's syndrome: a case report.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non | 2005 |
Reduced nitric oxide synthase and cyclo-oxygenase activity in the uterus of non-obese diabetic mice.
Topics: Animals; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 1; Dinoprostone; Enzyme Activation; Fema | 2006 |
Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Glucocorticoids; Humans; In | 2007 |
[Sweet's syndrome: a propos of 8 cases].
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Anti-Inflammatory Agents, N | 2007 |
Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms.
Topics: Adult; Aged; Antigen-Antibody Complex; Catalase; Female; Humans; Hydrogen Peroxide; Indomethacin; Ki | 1983 |
Treatment of Sjogren's syndrome with essential fatty acids, pyridoxine and vitamin C.
Topics: Ascorbic Acid; Aspartate Aminotransferases; Aspirin; Fatty Acids, Essential; Female; Humans; Indomet | 1982 |
Polymorphonuclear leucocytes release a factor(s) that induces platelet aggregation and ATP release after interaction with insoluble and surface-fixed immune complexes.
Topics: Adenosine Triphosphate; Antigen-Antibody Complex; Blood Coagulation Factors; Cell Membrane; Glucuron | 1982 |
Impaired indomethacin-boosting of the defective natural killer cell activity in patients with primary Sjögren's syndrome.
Topics: Humans; Indomethacin; Killer Cells, Natural; Sjogren's Syndrome; Stimulation, Chemical | 1986 |
Interleukin 2 defect in the peripheral blood and the lung in patients with Sjögren's syndrome.
Topics: Adult; Female; Humans; Indomethacin; Interleukin-1; Interleukin-2; Lung; Macrophages; Middle Aged; P | 1986 |