indomethacin has been researched along with Shock in 16 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Shock: A pathological condition manifested by failure to perfuse or oxygenate vital organs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of thromboxane and prostacyclin in circulatory shock of intestinal origin was investigated in anesthetized dogs by measuring their stable metabolites, thromboxane B2 (TXB2) and 6-keto-PGF1 alpha, respectively, in superior mesenteric vein (SMV), right ventricle (RV), and aorta during superior mesenteric artery occlusion-induced (SMAO) shock and by inhibiting prostanoid synthesis with indomethacin (IM)." | 7.67 | Intestinal and arterial plasma thromboxane and prostacyclin levels in shock: effects of indomethacin. ( Mózes, T; Wieszt, E, 1989) |
| "The role of eicosanoids as one of the main shock mediators was demonstrated in experiments anesthetized dogs with modeled postischemic shock using premedication with indometacin and/or quercetin." | 3.69 | [The role of the eicosanoids in the development of a postischemic shock reaction]. ( Sahach, VF; Zhukova, AV, 1996) |
| "The effects of platelet-activating factor (PAF) on prostanoid release during mesenteric ischemia-reperfusion-induced shock were investigated in anesthesized dogs 1) by measuring plasma levels of prostaglandin (PG)F2 alpha, 6-keto-PGF1 alpha and thromboxane (TX)B2 in the superior mesenteric vein during reperfusion following 2 hr occlusion of the superior mesenteric artery; 2) by monitoring the effects of BN 52021, a specific PAF receptor antagonist and indomethacin on hemodynamic parameters and prostanoid levels; and 3) by studying circulatory responses to PAF and PGF2 alpha injected into the superior mesenteric vein in the presence of BN 52021 or indomethacin." | 3.68 | Interactions between platelet-activating factor and prostanoids during mesenteric ischemia-reperfusion-induced shock in the anesthetized dog. ( Braquet, P; Filep, JG; Mózes, T, 1991) |
| "The role of thromboxane and prostacyclin in circulatory shock of intestinal origin was investigated in anesthetized dogs by measuring their stable metabolites, thromboxane B2 (TXB2) and 6-keto-PGF1 alpha, respectively, in superior mesenteric vein (SMV), right ventricle (RV), and aorta during superior mesenteric artery occlusion-induced (SMAO) shock and by inhibiting prostanoid synthesis with indomethacin (IM)." | 3.67 | Intestinal and arterial plasma thromboxane and prostacyclin levels in shock: effects of indomethacin. ( Mózes, T; Wieszt, E, 1989) |
| "The role of PGF2 alpha in circulatory shock of intestinal origin was investigated in anesthetized dogs by measuring PGF2 alpha levels in superior mesenteric vein, right ventricle, aorta, and femoral vein during superior mesenteric artery occlusion-induced shock by comparing the circulatory effects of exogenous PGF2 alpha injected into either the superior mesenteric or the femoral vein and by inhibiting of prostanoid synthesis with indomethacin." | 3.67 | Role of PGF2 alpha in the superior mesenteric artery-induced shock. ( Mózes, T; Wieszt, E; Zahajszky, T, 1989) |
| "The role of prostanoids in respiratory failure during circulatory shock of intestinal origin was investigated in anesthetized, non-ventilated dogs by measuring PGF2 alpha thromboxane B2 (TXB2) and 6-keto prostaglandin F1 alpha (PGF1 alpha) in arterial and mixed venous (right ventricle) blood samples during superior mesenteric artery occlusion-induced (SMAO) shock." | 3.67 | Role of prostanoids in respiratory failure during circulatory shock of intestinal origin in dogs. ( Mózes, T; Wieszt, E, 1989) |
| "Dazoxiben pretreatment also moderated the rise of plasma prostacyclin, but it augmented circulating prostaglandin E2 following the release of SAO." | 1.27 | Inhibition of thromboxane biosynthesis in splanchnic ischemia shock. ( Glenn, TM; Oei, HH; Robson, RD; Sakane, Y; Zoganas, HC, 1986) |
| "Animals were subjected to hypovolemic shock by withdrawing volumes of blood necessary to maintain a systolic pressure of 30-40 mm Hg for 105-110 min." | 1.26 | Hypovolemic models of acute tubular necrosis in the rat kidney. ( Bulger, RE; Dobyan, DC; Nagle, RB, 1977) |
| "Dogs treated with indomethacin prior to SAO shock did not exhibit a significant increase in portal venous PGF2alpha." | 1.26 | Release of prostaglandin F2alpha during splanchnic artery occlusion shock. ( Bridenbaugh, GA; Flynn, JT; Lefer, AM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lankisch, PG | 1 |
| Koop, H | 1 |
| Adams, HR | 1 |
| Goldfarb, RD | 1 |
| Glenn, TM | 2 |
| Jablonická, K | 1 |
| Kovalcík, V | 1 |
| Saeed, SA | 1 |
| Simjee, RU | 1 |
| Mahmood, F | 1 |
| Rahman, NN | 1 |
| Zhukova, AV | 1 |
| Sahach, VF | 1 |
| Dobyan, DC | 1 |
| Nagle, RB | 1 |
| Bulger, RE | 1 |
| Korbut, R | 1 |
| Ocetkiewicz, A | 1 |
| Gryglewski, RJ | 1 |
| Flynn, JT | 1 |
| Bridenbaugh, GA | 1 |
| Lefer, AM | 1 |
| Filep, JG | 1 |
| Braquet, P | 1 |
| Mózes, T | 4 |
| Wieszt, E | 3 |
| Zahajszky, T | 1 |
| Sagach, VF | 1 |
| Oei, HH | 1 |
| Zoganas, HC | 1 |
| Sakane, Y | 1 |
| Robson, RD | 1 |
| Arturson, G | 1 |
3 reviews available for indomethacin and Shock
| Article | Year |
|---|---|
[Current concept of diagnosis and therapy of acute pancreatitis (author's transl)].
Topics: Acute Disease; Acute Kidney Injury; Analgesics; Animals; Antacids; Anti-Bacterial Agents; Glucagon; | 1980 |
Pharmacologic problems in shock research.
Topics: Adrenergic alpha-Antagonists; Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age | 1983 |
Burn shock.
Topics: Animals; Blood Circulation; Burns; Capillary Permeability; Catecholamines; Dextrans; Dogs; Edema; He | 1974 |
13 other studies available for indomethacin and Shock
| Article | Year |
|---|---|
Regulation of lysosomal membrane stabilization via cyclic nucleotides and prostaglandins: the effects of steroids and indomethacin.
Topics: Animals; Dexamethasone; Dogs; Female; Indomethacin; Intracellular Membranes; Lysosomes; Male; Nucleo | 1983 |
[Pharmacologically influenced hypocalcemia in tourniquet shock in rats (author's transl)].
Topics: Animals; Coronary Disease; Glucocorticoids; Histamine; Indomethacin; Male; Rats; Rats, Inbred Strain | 1981 |
Dual inhibition of platelet-activating factor and arachidonic acid metabolism by ajmaline and effect on carrageenan-induced rat paw oedema.
Topics: Ajmaline; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Carbon Radioisotopes; Carrageenan; Ed | 1993 |
[The role of the eicosanoids in the development of a postischemic shock reaction].
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Eicosanoids; Hemodynamics; Hindlimb; Indomethacin; Ischemi | 1996 |
Hypovolemic models of acute tubular necrosis in the rat kidney.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Indomethacin; Kidney Tubular Necrosis, Acute; | 1977 |
The influence of hydrocortisone and indomethacin on the release of prostaglandin-like substances during circulatory shock in cats, which was induced by an intravenous administration of rabbit blood.
Topics: Animals; Cats; Drug Interactions; Female; Hydrocortisone; Indomethacin; Male; Phenoxybenzamine; Prop | 1978 |
Release of prostaglandin F2alpha during splanchnic artery occlusion shock.
Topics: Animals; Blood Proteins; Cathepsins; Dogs; Indomethacin; Ischemia; Ligation; Male; Mesenteric Arteri | 1976 |
Interactions between platelet-activating factor and prostanoids during mesenteric ischemia-reperfusion-induced shock in the anesthetized dog.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Diterpenes; Dogs; Ginkgolides; Hemodynamics; Indom | 1991 |
Intestinal and arterial plasma thromboxane and prostacyclin levels in shock: effects of indomethacin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Dogs; Epoprostenol; Indomethacin; Male; Mesen | 1989 |
Role of PGF2 alpha in the superior mesenteric artery-induced shock.
Topics: Animals; Blood Pressure; Dinoprost; Dogs; Hemodynamics; Indomethacin; Intestinal Mucosa; Intestines; | 1989 |
Role of prostanoids in respiratory failure during circulatory shock of intestinal origin in dogs.
Topics: Animals; Dogs; Indomethacin; Male; Mesenteric Vascular Occlusion; Prostaglandins; Respiratory Insuff | 1989 |
[Effect of cyclo- and lipoxygenase blockade on the development of immunogenic shock].
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Immune System Diseases; Indomethacin; Lipoxygenase Inhibit | 1988 |
Inhibition of thromboxane biosynthesis in splanchnic ischemia shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cardiac Output; Dogs; Female; Glucuronidase; | 1986 |