indomethacin has been researched along with Sepsis in 45 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats." | 7.75 | Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009) |
| "In this research, the role of leptin on sepsis-induced organ dysfunction was evaluated." | 7.74 | Leptin protects vital organ functions after sepsis through recovering tissue myeloperoxidase activity: an anti-inflammatory role resonating with indomethacin. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2007) |
| "A preterm male infant with a patent ductus arteriosus developed neutropenia during treatment with indomethacin." | 7.73 | Indomethacin-associated neutropenia with subsequent Gram-negative sepsis in a preterm infant. Cause or coincidence? ( Bengtsson, BO; Milstein, JM; Sherman, MP, 2006) |
| "We investigated the effect of 16,16-dimethyl prostaglandin E2 indomethacin and Ginkgo biloba extract on the survival in two experimental sepsis models in rats due to administration of 1 x 10(7) cfu and 1 x 10(9) cfu Escherichia coli." | 7.70 | The effects of prostaglandin E2 indomethacin & Ginkgo biloba extract on resistance to experimental sepsis. ( Cantürk, NZ; Cantürk, Z; Dülger, M; Utkan, NZ; Yenisey, C; Yildirir, C, 1998) |
| "Sepsis was produced in piglets by bolus intravenous injection of 10(9) live Escherichia coli followed by an infusion of 10(9) E." | 5.27 | Indomethacin and the gastric mucosal blood flow changes of sepsis. ( Nilsson, LO; Stein, TA; Stone, AM; Wise, L, 1983) |
| " lingzhi and its autodigested product (AD-GL) against gut inflammation and endogenous sepsis induced in mice by the oral administration of indomethacin (IND)." | 3.88 | Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes). ( Adachi, Y; Igami, K; Ishibashi, KI; Ishimoto, Y; Ito, H; Miyazaki, T; Ohno, N; Yamanaka, D, 2018) |
| " Magnesium sulfate administration, steroid administration, maternal diabetes mellitus, gestational age at delivery, indomethacin exposure, birthweight, and chorioamnionitis were all considered as possible covariates in the multivariable regression models." | 3.83 | Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes. ( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016) |
| " The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats." | 3.75 | Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009) |
| "In this research, the role of leptin on sepsis-induced organ dysfunction was evaluated." | 3.74 | Leptin protects vital organ functions after sepsis through recovering tissue myeloperoxidase activity: an anti-inflammatory role resonating with indomethacin. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2007) |
| " In a phenylephrine-contracted canine carotid artery ring preparation, we found that both canine and human Lzm-S, at concentrations similar to those found in sepsis, produced vasorelaxation." | 3.74 | Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation. ( Bose, R; Cheng, ZQ; Jacobs, H; Kasian, K; Light, RB; Mink, SN; Santos Martinez, LE, 2008) |
| "A preterm male infant with a patent ductus arteriosus developed neutropenia during treatment with indomethacin." | 3.73 | Indomethacin-associated neutropenia with subsequent Gram-negative sepsis in a preterm infant. Cause or coincidence? ( Bengtsson, BO; Milstein, JM; Sherman, MP, 2006) |
| "We investigated the effect of 16,16-dimethyl prostaglandin E2 indomethacin and Ginkgo biloba extract on the survival in two experimental sepsis models in rats due to administration of 1 x 10(7) cfu and 1 x 10(9) cfu Escherichia coli." | 3.70 | The effects of prostaglandin E2 indomethacin & Ginkgo biloba extract on resistance to experimental sepsis. ( Cantürk, NZ; Cantürk, Z; Dülger, M; Utkan, NZ; Yenisey, C; Yildirir, C, 1998) |
| "Preterm infants with exposure to antenatal indomethacin might be at increased risk of grade I and II intraventricular haemorrhage and those with both ante- and postnatal exposure at an increased risk of necrotising enterocolitis and sepsis." | 3.70 | Perinatal indomethacin treatment and neonatal complications in preterm infants. ( Ikonen, S; Ojala, R; Tammela, O, 2000) |
| " Recently, we documented a sepsis-related depression in concanavalin A (ConA)-induced T-cell proliferation and intracellular Ca2+ (Ca2+i) mobilization." | 3.69 | Role of Ca2+ in prostaglandin E2-induced T-lymphocyte proliferative suppression in sepsis. ( Ahmad, S; Choudhry, MA; Sayeed, MM, 1995) |
| " We studied the effect of combination interleukin 1 beta and indomethacin sodium therapy on macrophage hyperactivity and survival after sepsis in a murine burn model." | 3.68 | Modulation of macrophage hyperactivity improves survival in a burn-sepsis model. ( Collins, KH; Mannick, JA; O'Riordain, MG; Pilz, M; Rodrick, ML; Saporoschetz, IB, 1992) |
| " We tested the hypothesis that sustained sepsis in rats results in relative hyporesponsiveness to the pressor actions of NE and angiotensin II (AII)." | 3.67 | Diminished pressor response to exogenous norepinephrine and angiotensin II in septic, unanesthetized rats: evidence for a prostaglandin-mediated effect. ( Fink, MP; Fletcher, JR; Homer, LD, 1985) |
| "Sepsis is characterized by a systemic inflammatory response syndrome." | 1.43 | Design, Synthesis, and Structure-Activity Relationship Study of Novel Indole-2-carboxamide Derivatives as Anti-inflammatory Agents for the Treatment of Sepsis. ( Feng, J; Gu, Y; Liang, G; Liu, Z; Qiu, C; Tang, L; Xu, T; Zhang, Y; Zheng, S; Zhu, H, 2016) |
| "Pretreatment with indomethacin and N-(G)-nitro-L-arginine methyl ester did not prevent gentamicin-induced DA relaxation." | 1.40 | Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. ( Brown, N; Clark, RH; Cotton, RB; Ehinger, NJ; Goettel, JA; Paria, BC; Poole, SD; Reese, J; Rojas, MA; Shelton, EL; Slaughter, JC; Vucovich, MM; Wynn, JL, 2014) |
| "Sepsis was induced in rats by implanting fecal pellets containing Escherichia coli (150 CFU) and Bacteroides fragilis (10(4) CFU) into the abdominal cavity." | 1.30 | Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis. ( Choudhry, MA; Sayeed, MM; Uddin, S, 1998) |
| "Sepsis was induced in 225-250 g male rats (Sprague Dawley) by implanting fecal pellets containing Escherichia coli (100-150 CFU) and Bacteroides fragilis (10(4) CFU) into the abdominal cavity." | 1.30 | Prostaglandin E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis. ( Ahmad, S; Ahmed, Z; Choudhry, MA; Sayeed, MM, 1999) |
| "Sepsis was induced by cecal ligation and puncture (CLP)." | 1.29 | Alterations of ex vivo vascular reactivity in intraperitoneal sepsis. ( Chen, SJ; Wu, CC; Yen, MH, 1994) |
| "Sepsis was produced in piglets by bolus intravenous injection of 10(9) live Escherichia coli followed by an infusion of 10(9) E." | 1.27 | Indomethacin and the gastric mucosal blood flow changes of sepsis. ( Nilsson, LO; Stein, TA; Stone, AM; Wise, L, 1983) |
| "Dazoxiben blocked the increase in plasma TXB2, prevented pulmonary hypertension, and attenuated the increase in EVLW after E." | 1.27 | Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion. ( Carrico, CJ; Harlan, J; Hildebrandt, J; Price, S; Winn, R, 1986) |
| "Treatment with indomethacin prevented the 1-2 degrees C increase in body temperature observed in septic animals." | 1.27 | Fever is not responsible for the elevated glucose kinetics in sepsis. ( Bagby, GJ; Blakesley, HL; Lang, CH; Spitzer, JJ, 1987) |
| "When indomethacin was added in vitro, release of PGE2 by septic muscles and by normal muscles incubated in the presence of septic plasma was reduced by about 50%, but the increased proteolytic rate in these muscles was not affected." | 1.27 | Effect of indomethacin on proteolysis in septic muscle. ( Fischer, JE; Hasselgren, PO; James, JH; LaFrance, R; Peters, JC; Talamini, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (24.44) | 18.7374 |
| 1990's | 12 (26.67) | 18.2507 |
| 2000's | 11 (24.44) | 29.6817 |
| 2010's | 11 (24.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Özdemir, A | 1 |
| Altintop, MD | 1 |
| Turan-Zitouni, G | 1 |
| Çiftçi, GA | 1 |
| Ertorun, İ | 1 |
| Alataş, Ö | 1 |
| Kaplancikli, ZA | 1 |
| Liu, Z | 1 |
| Tang, L | 1 |
| Zhu, H | 1 |
| Xu, T | 1 |
| Qiu, C | 1 |
| Zheng, S | 1 |
| Gu, Y | 1 |
| Feng, J | 1 |
| Zhang, Y | 1 |
| Liang, G | 1 |
| Singh, G | 2 |
| Bhatti, R | 1 |
| Gupta, M | 1 |
| Kumar, A | 1 |
| Sharma, A | 1 |
| Singh Ishar, MP | 1 |
| Ishimoto, Y | 1 |
| Ishibashi, KI | 1 |
| Yamanaka, D | 1 |
| Adachi, Y | 2 |
| Ito, H | 1 |
| Igami, K | 1 |
| Miyazaki, T | 1 |
| Ohno, N | 2 |
| Rasooli, A | 1 |
| Fatemi, F | 1 |
| Hajihosseini, R | 1 |
| Vaziri, A | 1 |
| Akbarzadeh, K | 1 |
| Mohammadi Malayeri, MR | 1 |
| Dini, S | 1 |
| Foroutanrad, M | 1 |
| Ernst, W | 1 |
| Zimara, N | 1 |
| Hanses, F | 1 |
| Männel, DN | 1 |
| Seelbach-Göbel, B | 1 |
| Wege, AK | 1 |
| Vucovich, MM | 1 |
| Cotton, RB | 1 |
| Shelton, EL | 1 |
| Goettel, JA | 1 |
| Ehinger, NJ | 1 |
| Poole, SD | 1 |
| Brown, N | 1 |
| Wynn, JL | 1 |
| Paria, BC | 1 |
| Slaughter, JC | 1 |
| Clark, RH | 1 |
| Rojas, MA | 1 |
| Reese, J | 1 |
| Faucett, AM | 1 |
| Metz, TD | 1 |
| DeWitt, PE | 1 |
| Gibbs, RS | 1 |
| Saito, M | 1 |
| Nameda, S | 1 |
| Miura, NN | 1 |
| Nögel, SC | 1 |
| Chada, M | 1 |
| Schmidt, AM | 1 |
| Bosselmann, S | 1 |
| Kandler, M | 1 |
| Schweer, H | 1 |
| Watzer, B | 1 |
| Schneider, H | 1 |
| Gessner, A | 1 |
| Rascher, W | 1 |
| Subramani, J | 1 |
| Kathirvel, K | 1 |
| Leo, MD | 1 |
| Kuntamallappanavar, G | 1 |
| Uttam Singh, T | 1 |
| Mishra, SK | 1 |
| Sallmon, H | 1 |
| Weber, SC | 1 |
| Hüning, B | 1 |
| Stein, A | 1 |
| Horn, PA | 1 |
| Metze, BC | 1 |
| Dame, C | 1 |
| Bührer, C | 1 |
| Felderhoff-Müser, U | 1 |
| Hansmann, G | 1 |
| Koehne, P | 1 |
| Davis, JS | 1 |
| Ryan, ML | 1 |
| Shields, JM | 1 |
| Sola, JE | 1 |
| Perez, EA | 1 |
| Neville, HL | 1 |
| Rodriguez, MM | 1 |
| Chiang, PJ | 1 |
| Hsu, JF | 1 |
| Tsai, MH | 1 |
| Lien, R | 1 |
| Chiang, MC | 1 |
| Huang, HR | 1 |
| Chiang, CC | 1 |
| Liang, HF | 1 |
| Chu, SM | 1 |
| García-Herrera, J | 1 |
| Navarro, MA | 1 |
| Marca, MC | 1 |
| de la Osada, J | 1 |
| Rodríguez-Yoldi, MJ | 1 |
| Osterberg, J | 1 |
| Ljungdahl, M | 1 |
| Haglund, U | 1 |
| Bengtsson, BO | 1 |
| Milstein, JM | 1 |
| Sherman, MP | 1 |
| Patole, SK | 1 |
| Kumaran, V | 1 |
| Travadi, JN | 1 |
| Brooks, JM | 1 |
| Doherty, DA | 1 |
| Lin, J | 1 |
| Yan, GT | 1 |
| Xue, H | 1 |
| Hao, XH | 1 |
| Zhang, K | 1 |
| Wang, LH | 1 |
| Mink, SN | 1 |
| Kasian, K | 1 |
| Santos Martinez, LE | 1 |
| Jacobs, H | 1 |
| Bose, R | 1 |
| Cheng, ZQ | 1 |
| Light, RB | 1 |
| Short, BL | 1 |
| Miller, MK | 1 |
| Stroud, CY | 1 |
| Fletcher, JR | 3 |
| Nilsson, LO | 1 |
| Stone, AM | 1 |
| Stein, TA | 1 |
| Wise, L | 1 |
| Fink, MP | 2 |
| MacVittie, TJ | 1 |
| Casey, LC | 1 |
| Chen, SJ | 1 |
| Wu, CC | 1 |
| Yen, MH | 1 |
| Choudhry, MA | 3 |
| Ahmad, S | 2 |
| Sayeed, MM | 3 |
| Wang, P | 1 |
| Ba, ZF | 1 |
| Chaudry, IH | 1 |
| Cisneros, RL | 1 |
| Gibson, FC | 1 |
| Tzianabos, AO | 1 |
| Rudinsky, BF | 1 |
| Lozon, M | 2 |
| Bell, A | 2 |
| Hipps, R | 2 |
| Meadow, WL | 1 |
| Uddin, S | 1 |
| Cantürk, NZ | 1 |
| Utkan, NZ | 1 |
| Cantürk, Z | 1 |
| Yenisey, C | 1 |
| Yildirir, C | 1 |
| Dülger, M | 1 |
| Magder, S | 1 |
| Rastepagarnah, M | 1 |
| Ahmed, Z | 1 |
| Ojala, R | 1 |
| Ikonen, S | 1 |
| Tammela, O | 1 |
| Rudinsky, B | 1 |
| Meadow, W | 1 |
| O'Riordain, MG | 1 |
| Collins, KH | 1 |
| Pilz, M | 1 |
| Saporoschetz, IB | 1 |
| Mannick, JA | 1 |
| Rodrick, ML | 1 |
| Hasselgren, PO | 2 |
| Zamir, O | 1 |
| James, JH | 2 |
| Fischer, JE | 2 |
| Rasmussen, LT | 1 |
| Fandrem, J | 1 |
| Seljelid, R | 1 |
| Price, S | 1 |
| Harlan, J | 1 |
| Carrico, CJ | 1 |
| Hildebrandt, J | 1 |
| Winn, R | 1 |
| Lang, CH | 1 |
| Bagby, GJ | 1 |
| Blakesley, HL | 1 |
| Spitzer, JJ | 1 |
| Choudhary, G | 1 |
| Sharma, MP | 1 |
| Homer, LD | 1 |
| Talamini, M | 1 |
| LaFrance, R | 1 |
| Peters, JC | 1 |
| Arturson, G | 1 |
| Kent, TH | 1 |
| Cardelli, RM | 1 |
| Stamler, FW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indomethacin and Sepsis
| Article | Year |
|---|---|
Segmental absence of intestinal musculature: an increasingly reported pathology.
Topics: Abdomen, Acute; Abnormalities, Multiple; Adult; Cesarean Section; Digestive System Abnormalities; Du | 2012 |
Burn shock.
Topics: Animals; Blood Circulation; Burns; Capillary Permeability; Catecholamines; Dextrans; Dogs; Edema; He | 1974 |
43 other studies available for indomethacin and Sepsis
| Article | Year |
|---|---|
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents.
Topics: Animals; Cell Survival; Chalcones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Di | 2015 |
Design, Synthesis, and Structure-Activity Relationship Study of Novel Indole-2-carboxamide Derivatives as Anti-inflammatory Agents for the Treatment of Sepsis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Design; Ind | 2016 |
Indolyl-isoxazolidines attenuate LPS-stimulated pro-inflammatory cytokines and increase survival in a mouse model of sepsis: Identification of potent lead.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inflammation; Interleukin-6; | 2018 |
Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes).
Topics: Animals; beta-Glucans; Cells, Cultured; Cytokines; Fungal Polysaccharides; Gastrointestinal Diseases | 2018 |
Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Deuterium; Disease Models, Animal | 2019 |
Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Load; Betamethason | 2013 |
Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA.
Topics: Animals; Chemokine CXCL12; Ductus Arteriosus; Ductus Arteriosus, Patent; Gentamicins; Humans; In Vit | 2014 |
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Birth Weight; Case-Control Studies; Cerebral Hemorrhage; | 2016 |
Effect of SPG/indomethacin treatment on sepsis, interleukin-6 production, and expression of hepatic cytochrome P450 isoforms in differing strains of mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cytochrome P-450 CYP2E1; Cytochrome P-45 | 2009 |
Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis.
Topics: Animals; Animals, Newborn; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epoprostenol; Gene Expression | 2009 |
Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis.
Topics: Acetylcholine; Animals; Aorta; Atorvastatin; Biological Factors; Blood Cell Count; Blood Pressure; C | 2009 |
Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus.
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Echocardiography, Doppler; Female; Humans; Ibu | 2012 |
The impact of patent ductus arteriosus in neonates with late onset sepsis: a retrospective matched-case control study.
Topics: Age Factors; Bronchopulmonary Dysplasia; Case-Control Studies; Databases, Factual; Ductus Arteriosus | 2012 |
The effect of tumor necrosis factor-alpha on D-fructose intestinal transport in rabbits.
Topics: Animals; Biological Transport; Enterocytes; Enzyme Inhibitors; Fructose; Glucose Transporter Type 5; | 2004 |
Influence of cyclooxygenase inhibitors on gut immune cell distribution and apoptosis rate in experimental sepsis.
Topics: Animals; Apoptosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, A | 2006 |
Indomethacin-associated neutropenia with subsequent Gram-negative sepsis in a preterm infant. Cause or coincidence?
Topics: Cardiovascular Agents; Ductus Arteriosus, Patent; Enterobacter cloacae; Enterobacteriaceae Infection | 2006 |
Does patent ductus arteriosus affect feed tolerance in preterm neonates?
Topics: Age Factors; Analysis of Variance; Cardiovascular Agents; Ductus Arteriosus, Patent; Enteral Nutriti | 2007 |
Leptin protects vital organ functions after sepsis through recovering tissue myeloperoxidase activity: an anti-inflammatory role resonating with indomethacin.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Kidney; Leptin | 2007 |
Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
Topics: Aminoquinolines; Animals; Carotid Artery, Internal; Catalase; Cyclic GMP; Cyclic GMP-Dependent Prote | 2008 |
Comparison of thromboxane inhibitors to cyclooxygenase inhibitors on survival in a newborn rat model for group B streptococcal sepsis.
Topics: Animals; Animals, Newborn; Ibuprofen; Indomethacin; Rats; Rats, Inbred Strains; Sepsis; Streptococca | 1983 |
Indomethacin and the gastric mucosal blood flow changes of sepsis.
Topics: Animals; Escherichia coli Infections; Gastric Mucosa; Indomethacin; Sepsis; Swine | 1983 |
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Dogs; Escherichia coli Infections; Fe | 1984 |
The role of prostaglandins in sepsis.
Topics: Animals; Escherichia coli Infections; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins; | 1982 |
Alterations of ex vivo vascular reactivity in intraperitoneal sepsis.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Body Temperature; Cecum; Disease Models, Animal; D | 1994 |
Role of Ca2+ in prostaglandin E2-induced T-lymphocyte proliferative suppression in sepsis.
Topics: Animals; Calcium; Concanavalin A; Dinoprostone; Indomethacin; Lymphocyte Activation; Male; Rats; Rat | 1995 |
Nitric oxide. To block or enhance its production during sepsis?
Topics: Acetylcholine; Animals; Aorta, Thoracic; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitr | 1994 |
Passive transfer of poly-(1-6)-beta-glucotriosyl-(1-3)-beta-glucopyranose glucan protection against lethal infection in an animal model of intra-abdominal sepsis.
Topics: Adjuvants, Immunologic; Animals; beta-Glucans; Dinoprostone; Glucans; Immunotherapy, Adoptive; Indom | 1996 |
Group B streptococcal sepsis impairs cerebral vascular reactivity to acute hypercarbia in piglets.
Topics: Animals; Blood Pressure; Brain; Carbon Monoxide; Carotid Artery, Internal; Disease Models, Animal; H | 1996 |
Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis.
Topics: Animals; Bacteroides fragilis; Bacteroides Infections; Dinoprostone; Enzyme Activation; Escherichia | 1998 |
The effects of prostaglandin E2 indomethacin & Ginkgo biloba extract on resistance to experimental sepsis.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Ginkgo biloba; Indomethacin; Male; Oxytocics; Phyt | 1998 |
Role of neurosympathetic pathways in the vascular response to sepsis.
Topics: Adaptation, Physiological; Animals; Cyclooxygenase Inhibitors; Denervation; Disease Models, Animal; | 1998 |
Prostaglandin E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis.
Topics: Animals; Bacteroides fragilis; Bacteroides Infections; Dinoprostone; Disease Models, Animal; Down-Re | 1999 |
Perinatal indomethacin treatment and neonatal complications in preterm infants.
Topics: Cerebral Hemorrhage; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infa | 2000 |
Hemodynamic homeostasis during acute hypoxia in septic and nonseptic piglets: differential role of prostaglandins and nitric oxide.
Topics: Animals; Arginine; Hemodynamics; Homeostasis; Hypoxia; Indomethacin; Nitric Oxide; Prostaglandin Ant | 2000 |
Modulation of macrophage hyperactivity improves survival in a burn-sepsis model.
Topics: Animals; Burns; Indomethacin; Interleukin-1; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred A; | 1992 |
Prostaglandin E2 does not regulate total or myofibrillar protein breakdown in incubated skeletal muscle from normal or septic rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cycloheximide; Dinoprostone; In Vitro Techniques; Indo | 1990 |
Dynamics of blood components and peritoneal fluid during treatment of murine E. coli sepsis with beta-1,3-D-polyglucose derivatives. II. Interleukin 1, tumour necrosis factor, prostaglandin E2, and leukotriene B4.
Topics: Animals; Arachidonic Acids; Ascitic Fluid; beta-Glucans; Cytokines; Dinoprostone; Escherichia coli I | 1990 |
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
Topics: Animals; Body Water; Cyclooxygenase Inhibitors; Escherichia coli Infections; Female; Imidazoles; Ind | 1986 |
Fever is not responsible for the elevated glucose kinetics in sepsis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibito | 1987 |
Septicaemia: newer mode of therapy.
Topics: Adrenal Cortex Hormones; Blood Transfusion; Humans; Immunization, Passive; Indomethacin; Naloxone; S | 1987 |
Diminished pressor response to exogenous norepinephrine and angiotensin II in septic, unanesthetized rats: evidence for a prostaglandin-mediated effect.
Topics: Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Ele | 1985 |
Effect of indomethacin on proteolysis in septic muscle.
Topics: Amino Acids; Animals; Indomethacin; Male; Muscle Proteins; Muscles; Peptide Hydrolases; Prostaglandi | 1985 |
Small intestinal ulcers and intestinal flora in rats given indomethacin.
Topics: Animals; Anti-Bacterial Agents; Cecal Diseases; Ileum; Indomethacin; Intestinal Diseases; Intestine, | 1969 |