indomethacin has been researched along with Seizures in 36 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 7.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| "In rats kainic acid-induced seizures were accompanied by time-dependent cerebral cysteinyl-leukotriene (LT) and prostaglandin (PG) F2 alpha formation." | 7.68 | Cysteinyl-leukotriene production during limbic seizures triggered by kainic acid. ( Simmet, T; Tippler, B, 1990) |
| "Seizures were induced in ventilated rats maintained on 70% N2O and 30% O2 by the i." | 5.26 | Local cerebral blood flow in the brain during bicuculline-induced seizures and the modulating influence of inhibition of prostaglandin synthesis. ( Ingvar, M; Nilsson, B; Siesjö, BK, 1981) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 3.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| " The present study evaluated the effects of progesterone and its active metabolite, allopregnanolone against PTX-induced seizures, brain lipid peroxidation and DNA fragmentation in male mice." | 3.76 | Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice. ( Arora, SK; Chakrabarti, A; Hota, D; Khanduja, KL; Prakash, A; Singh, S, 2010) |
| "In rats kainic acid-induced seizures were accompanied by time-dependent cerebral cysteinyl-leukotriene (LT) and prostaglandin (PG) F2 alpha formation." | 3.68 | Cysteinyl-leukotriene production during limbic seizures triggered by kainic acid. ( Simmet, T; Tippler, B, 1990) |
| "We examined the role of prostanoids to bicuculline-induced seizures in newborn pigs." | 3.67 | Role of prostanoids in cerebrovascular responses during seizures in piglets. ( Busija, DW; Leffler, CW, 1989) |
| "The effect of inhibiting endogenous brain thromboxane (TXB2) on pentylenetetrazole-induced seizures was studied using the thromboxane synthetase inhibitors OKY-1581 (20 mg/kg) and UK 38,485 (50 mg/kg)." | 3.67 | The effect of inhibiting brain thromboxane biosynthesis on pentylenetetrazole-induced seizure threshold. ( Centra, M; Lysz, TW; McGinley, S, 1985) |
| "In contrast, the incidence of seizures was reduced 18 h after LPS injection." | 1.33 | The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction. ( Akarsu, ES; Algan, E; Ozdayi, S; Ulupinar, F, 2006) |
| "As parameters of epileptic seizure, seizure threshold (number of toss-ups to induce convulsion), duration of actual convulsion and duration of post actual convulsive period (period from the offset of convulsion to full recovery) were evaluated." | 1.33 | Cyclooxygenase system contributes to the maintenance of post convulsive period of epileptic phenomena in the genetically epileptic El mice. ( Okada, K; Tsuji, S; Yamashita, U, 2006) |
| "Before hyperbaric oxygenation-induced convulsions in rats the initial decrease in blood flow gave place to hyperemia, Po(2) increased." | 1.33 | Effect of indomethacin on cerebral blood flow and development of oxygen convulsions. ( Alekseeva, OS; Gutsaeva, DR; Khmel'nitskii, AV; Moskvin, AN; Sharapov, OI, 2006) |
| "Stress affects seizure susceptibility in animals and humans, but the underlying mechanisms are obscure." | 1.31 | Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. ( Reddy, DS; Rogawski, MA, 2002) |
| "COX-2 selective inhibitors induced the seizure at earlier onset and more severe mortality within the first hour than indomethacin and aspirin." | 1.30 | Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus. ( Baik, EJ; Kim, EJ; Lee, SH; Moon, C, 1999) |
| "No such convulsion has been described to date in pregnancy." | 1.29 | Indomethacin-induced maternal convulsion in the treatment of preterm labour. ( DeChazal, R; Halligan, A; Nan, A; Taylor, D, 1993) |
| "Indomethacin pretreatment markedly reduced the number of convulsion-resistant animals." | 1.27 | Anticonvulsive effects of endogenous prostaglandins formed in brain of spontaneously convulsing gerbils. ( Förstermann, U; Hertting, G; Seregi, A, 1984) |
| "Pretreatment with indomethacin abolished the formation of PGF2 alpha but significantly enhanced the biosynthesis of immunoreactive LTC4-like material at 18 min after the beginning of seizures." | 1.27 | Characterization of seizure-induced cysteinyl-leukotriene formation in brain tissue of convulsion-prone gerbils. ( Hertting, G; Seregi, A; Simmet, T, 1988) |
| "Seizures were induced in female Wistar rats by electroconvulsive shock (ECS) or administration of pentetrazole (PTZ)." | 1.26 | Regional distribution of arachidonic acid metabolites in rat brain following convulsive stimuli. ( Anhut, H; Berchtold-Kanz, E; Heldt, R; Hertting, G; Neufang, B, 1981) |
| "Seizures were induced in ventilated rats maintained on 70% N2O and 30% O2 by the i." | 1.26 | Local cerebral blood flow in the brain during bicuculline-induced seizures and the modulating influence of inhibition of prostaglandin synthesis. ( Ingvar, M; Nilsson, B; Siesjö, BK, 1981) |
| "Since the mechanism of seizures inducted by exposure to oxygen high pressure (OHP) is not fully elucidated, this study was designed to investigate the effect of exogenous PG s and of indomethacin (a Pg synthesis inhibitor) upon the development and consequences of seizures in rats exposed to OHP (5 ata)." | 1.26 | Effect of prostaglandin E2 and of indomethacin upon cerebral and pulmonary consequences of exposure to hyperbaric oxygen in rats. ( Dabrowiecki, Z; Herbaczyńska-Cedro, K; Rap, ZM; Ruszczewski, P; Truskolaski, P, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (55.56) | 18.7374 |
| 1990's | 8 (22.22) | 18.2507 |
| 2000's | 6 (16.67) | 29.6817 |
| 2010's | 2 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbalho, PG | 1 |
| Lopes-Cendes, I | 1 |
| Maurer-Morelli, CV | 1 |
| Singh, S | 1 |
| Hota, D | 1 |
| Prakash, A | 1 |
| Khanduja, KL | 1 |
| Arora, SK | 1 |
| Chakrabarti, A | 1 |
| Akarsu, ES | 1 |
| Ozdayi, S | 1 |
| Algan, E | 1 |
| Ulupinar, F | 1 |
| Okada, K | 2 |
| Yamashita, U | 2 |
| Tsuji, S | 2 |
| Moskvin, AN | 1 |
| Alekseeva, OS | 1 |
| Gutsaeva, DR | 1 |
| Khmel'nitskii, AV | 1 |
| Sharapov, OI | 1 |
| Bauer, B | 1 |
| Hartz, AM | 1 |
| Pekcec, A | 1 |
| Toellner, K | 1 |
| Miller, DS | 1 |
| Potschka, H | 1 |
| Förstermann, U | 1 |
| Seregi, A | 2 |
| Hertting, G | 3 |
| Berchtold-Kanz, E | 1 |
| Anhut, H | 1 |
| Heldt, R | 1 |
| Neufang, B | 1 |
| Ingvar, M | 1 |
| Nilsson, B | 1 |
| Siesjö, BK | 1 |
| Baran, H | 1 |
| Vass, K | 1 |
| Lassmann, H | 1 |
| Hornykiewicz, O | 1 |
| Halligan, A | 1 |
| Nan, A | 1 |
| DeChazal, R | 1 |
| Taylor, D | 1 |
| Paoletti, AM | 1 |
| Piccirilli, S | 1 |
| Costa, N | 1 |
| Rotiroti, D | 1 |
| Bagetta, G | 1 |
| Nisticò, G | 1 |
| Paech, M | 1 |
| Kristensen, J | 1 |
| Ilett, KF | 1 |
| Sánchez-Hernandez, MC | 1 |
| Delgado, J | 1 |
| Navarro, AM | 1 |
| Orta, JC | 1 |
| Hernandez, M | 1 |
| Conde, J | 1 |
| Baik, EJ | 1 |
| Kim, EJ | 1 |
| Lee, SH | 1 |
| Moon, C | 1 |
| Yuhi, T | 1 |
| Reddy, DS | 1 |
| Rogawski, MA | 1 |
| Eeg-Olofsson, O | 1 |
| Malmros, I | 1 |
| Elwin, CE | 1 |
| Steen, B | 1 |
| Fairhead, FW | 1 |
| Ruszczewski, P | 1 |
| Truskolaski, P | 1 |
| Dabrowiecki, Z | 1 |
| Rap, ZM | 1 |
| Herbaczyńska-Cedro, K | 1 |
| Rosenkranz, RP | 1 |
| Killam, KF | 1 |
| Wallenstein, MC | 2 |
| Bito, LZ | 1 |
| Fujimoto, N | 1 |
| Kaneko, T | 1 |
| Eguchi, N | 1 |
| Urade, Y | 1 |
| Mizuno, N | 1 |
| Hayaishi, O | 1 |
| Simmet, T | 2 |
| Tippler, B | 1 |
| Khanna, N | 1 |
| Ray, A | 1 |
| Alkondon, M | 1 |
| Sen, P | 1 |
| Busija, DW | 1 |
| Leffler, CW | 1 |
| de Campos, DI | 1 |
| Cunha, FQ | 1 |
| Ferreira, SH | 2 |
| Duarte, ID | 1 |
| Nakamura, M | 1 |
| McGinley, S | 1 |
| Centra, M | 1 |
| Lysz, TW | 1 |
| Caprino, L | 1 |
| Borrelli, F | 1 |
| Falchetti, R | 1 |
| Done, AK | 1 |
| Selye, H | 2 |
| Solymoss, B | 1 |
| Toth, S | 1 |
| Varga, S | 1 |
| Brass, H | 1 |
36 other studies available for indomethacin and Seizures
| Article | Year |
|---|---|
Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Disease Models, Animal; D | 2016 |
Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Finaster | 2010 |
The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction.
Topics: Animals; Convulsants; Cyclooxygenase Inhibitors; Diclofenac; Escherichia coli; Indomethacin; Lipopol | 2006 |
Cyclooxygenase system contributes to the maintenance of post convulsive period of epileptic phenomena in the genetically epileptic El mice.
Topics: Animals; Cerebral Cortex; Cyclooxygenase 2; Disease Models, Animal; Epilepsy; Indomethacin; Injectio | 2006 |
Effect of indomethacin on cerebral blood flow and development of oxygen convulsions.
Topics: Animals; Cyclooxygenase Inhibitors; Hyperbaric Oxygenation; Hyperemia; Indomethacin; Male; Rats; Rat | 2006 |
Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Capillaries; | 2008 |
Anticonvulsive effects of endogenous prostaglandins formed in brain of spontaneously convulsing gerbils.
Topics: Animals; Anticonvulsants; Brain; Gerbillinae; Indomethacin; Prostaglandin-Endoperoxide Synthases; Pr | 1984 |
Regional distribution of arachidonic acid metabolites in rat brain following convulsive stimuli.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Electroshock; Female; Indomethacin; Pentylenete | 1981 |
Local cerebral blood flow in the brain during bicuculline-induced seizures and the modulating influence of inhibition of prostaglandin synthesis.
Topics: Animals; Autoradiography; Bicuculline; Cerebrovascular Circulation; Indomethacin; Male; Prostaglandi | 1981 |
The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1994 |
Indomethacin-induced maternal convulsion in the treatment of preterm labour.
Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications; | 1993 |
Systemic administration of N omega-nitro-L-arginine methyl ester and indomethacin reduces the elevation of brain PGE2 content and prevents seizures and hippocampal damage evoked by LiCl and tacrine in rat.
Topics: Animals; Cholinesterase Inhibitors; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Hippocampus; I | 1998 |
Nonsteroidal antiinflammatory drugs during lactation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Contraindications; Female; Humans; Indometh | 1998 |
Seizures induced by NSAID.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Indomethacin; Male; Seizures | 1999 |
Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus.
Topics: Animals; Aspirin; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibito | 1999 |
Cyclooxygenase-2 expression in the hippocampus of genetically epilepsy susceptible El mice was increased after seizure.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2001 |
Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility.
Topics: 5-alpha Reductase Inhibitors; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Convu | 2002 |
Convulsions in a breast-fed infant after maternal indomethacin.
Topics: Adult; Breast Feeding; Female; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Mal | 1978 |
Convulsions in a breast-fed infant after maternal indomethacin.
Topics: Breast Feeding; Female; Humans; Indomethacin; Infant; Infant, Newborn; Milk, Human; Seizures | 1978 |
Effect of prostaglandin E2 and of indomethacin upon cerebral and pulmonary consequences of exposure to hyperbaric oxygen in rats.
Topics: Animals; Body Weight; Brain; Hyperbaric Oxygenation; Indomethacin; Lipid Metabolism; Lung; Male; Org | 1979 |
Potentiation of pentylenetetrazole and electroshock induced seizures by prostaglandin F2 alpha.
Topics: Animals; Drug Synergism; Electroshock; Indomethacin; Male; Mice; Mice, Inbred ICR; Pentylenetetrazol | 1979 |
Prostaglandin E1-induced alterations in visually-evoked response and production of epileptiform activity.
Topics: Acetaminophen; Animals; Bromcresol Green; Electroencephalography; Evoked Potentials; Female; Indomet | 1977 |
Biochemical and immunohistochemical demonstration of a tightly bound form of prostaglandin E2 in the rat brain.
Topics: Animals; Binding Sites; Brain; Indomethacin; Male; Organ Specificity; Pentylenetetrazole; Prostaglan | 1992 |
Cysteinyl-leukotriene production during limbic seizures triggered by kainic acid.
Topics: Animals; Brain; Dinoprost; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; Indomet | 1990 |
Effect of beta-adrenoceptor antagonists and some related drugs on maximal electroshock seizures in mice.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Cyproheptadine; Electroshock; Female; Indomethacin; | 1989 |
Characterization of seizure-induced cysteinyl-leukotriene formation in brain tissue of convulsion-prone gerbils.
Topics: Animals; Brain; Dinoprost; Female; Gerbillinae; Indomethacin; Kinetics; Leukotriene E4; Male; Prosta | 1988 |
Role of prostanoids in cerebrovascular responses during seizures in piglets.
Topics: Animals; Animals, Newborn; Bicuculline; Cerebrovascular Circulation; Fatty Acids; Female; Indomethac | 1989 |
A new mechanism of action of dipyrone: blockade of the release of a nociceptive factor from macrophages.
Topics: Aminopyrine; Animals; Dipyrone; Escherichia coli; Hyperalgesia; Indomethacin; Macrophages; Mice; Noc | 1988 |
Participation of the sympathetic system in acetic acid-induced writhing in mice.
Topics: Acetates; Animals; Indomethacin; Male; Mice; Seizures; Sympathetic Nervous System; Sympatholytics | 1988 |
Differential effect of prostaglandin synthetase inhibitor pretreatment on pentylenetetrazol-induced seizures in rat.
Topics: Acetaminophen; Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Electric Stimulation; Electroen | 1985 |
The effect of inhibiting brain thromboxane biosynthesis on pentylenetetrazole-induced seizure threshold.
Topics: Animals; Brain; Brain Chemistry; Female; Imidazoles; Indomethacin; Methacrylates; Mice; Pentylenetet | 1985 |
General pharmacological properties of 4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol (ditazol).
Topics: Amphetamine; Animals; Anti-Inflammatory Agents; Atropine; Blood Pressure; Cats; Chlorpromazine; Etha | 1973 |
Antipyretics.
Topics: Acetaminophen; Analgesics; Aspirin; Child; Health Education; Humans; Indomethacin; Mefenamic Acid; P | 1972 |
Effect of catatoxic steroids upon established morbid changes.
Topics: Animals; Digitoxin; Female; Indomethacin; Intestine, Small; Nitriles; Peritonitis; Poisoning; Pregne | 1971 |
Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.
Topics: Animals; Digitoxin; Drug Antagonism; Female; Indomethacin; Intestinal Diseases; Jejunum; Microsomes, | 1971 |
[Therapeutic possibilities in chronic glomerulonephritis].
Topics: Adolescent; Adult; Azathioprine; Chlorambucil; Chronic Disease; Glomerulonephritis; Humans; Immunosu | 1969 |